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array:22 [ "pii" => "S0025775300711845" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71184-5" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71184" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:41-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 182 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 106 "PDF" => 71 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300711857" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71185-7" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71185" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:46-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6371 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 6235 "PDF" => 127 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Valoración diagnóstica clínica y analítica de la trombosis venosa profunda de miembros inferiores" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "46" "paginaFinal" => "49" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical analytic diagnostic assessment of deep vein thrombosis of lower limbs" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Antonio-Javier Trujillo-Santos, M.<span class="elsevierStyleSup">a</span> Dolores García de Lucas, Rafael Ríos-Tamayo, Alberto Jiménez-Puente, Juan-Enrique García-Sánchez" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Antonio-Javier" "apellidos" => "Trujillo-Santos" ] 1 => array:2 [ "nombre" => "M.<span class="elsevierStyleSup">a</span>" "apellidos" => "Dolores García de Lucas" ] 2 => array:2 [ "nombre" => "Rafael" "apellidos" => "Ríos-Tamayo" ] 3 => array:2 [ "nombre" => "Alberto" "apellidos" => "Jiménez-Puente" ] 4 => array:2 [ "nombre" => "Juan-Enrique" "apellidos" => "García-Sánchez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300711857?idApp=UINPBA00004N" "url" => "/00257753/0000011400000002/v1_201307291440/S0025775300711857/v1_201307291440/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Influencia de la presencia de sofocos durante la menopausia sobre el metabolismo del óxido nítrico. Efecto del tratamiento hormonal sustitutivo" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "41" "paginaFinal" => "45" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Mariano Leal Hernández, José Abellán Alemán, Luis F. Carbonell Meseguer, Julián Díaz Fernández, Francisco Alberto García Sánchez, José María Martínez Selva" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Mariano Leal" "apellidos" => "Hernández" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "José" "apellidos" => "Abellán Alemán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Luis F." "apellidos" => "Carbonell Meseguer" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Julián" "apellidos" => "Díaz Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 4 => array:3 [ "nombre" => "Francisco Alberto" "apellidos" => "García Sánchez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "José" "apellidos" => "María Martínez Selva" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Medicina Interna. CS Beniaján-San Andrés. Murcia" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Fisiología y Farmacología. Facultad de Medicina. Universidad de Murcia" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departamento de Psicofisiología. Facultad de Psicología-Educación. Universidad de Murcia" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "**" "correspondencia" => "Correspondencia: Dr. M. Leal Hernández. Leales, 29, La Arboleja. 30009 Murcia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Influence of the presence of hot flushes durig the menopause in the metabolism of nitric oxide. Influence of hormone replacement therapy" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-02-08" "fechaAceptado" => "1999-06-03" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec221137" "palabras" => array:4 [ 0 => "Sofocos" 1 => "Menopausia" 2 => "Óxido nítrico" 3 => "Tratamiento hormonal sustitutivo" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar si la presencia de sofocos durante la menopausia se asocia a alteracionesen el metabolismo del óxido nítrico, actividad antioxidante total y otros parámetros bioquímicos.Determinar el efecto del tratamiento hormonal sustitutivo (THS) sobre el metabolismodel óxido nítrico, actividad antioxidante total y otros parámetros bioquímicos en mujeres menopáusicascon sofocos y sin ellos.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio experimental que incluye 29 mujeres menopáusicas con sofocos(se les aplicó THS a 12) y 20 sin sofocos (se les aplicó THS a 6), sanas, de 45 a 55 años deedad, con un período de menopausia de entre uno y 5 años. Grupo control formado por 14 mujeresen edad fértil. Determinación de estradiol, nitritos-nitratos, actividad antioxidante total yparámetros generales, antes y 4-6 meses después del THS.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Previamente al THS la presencia de sofocos se asoció a un menor nivel de actividadantioxidante total (p < 0,05) en plasma, sin diferencias en las concentraciones de nitritosnitratos.El THS se asoció a un incremento en las concentraciones de nitritos-nitratos y actividadantioxidante total (p < 0,05) en las mujeres menopáusicas, independientemente de quepresenten sofocos o no.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La presencia de sofocos durante la menopausia indica un mayor grado de estrésoxidativo y por tanto un mayor riesgo cardiovascular. El THS disminuye el grado de estrés oxidativoy aumenta los metabolitos derivados del óxido nítrico en las mujeres menopáusicas cono sin sofocos.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To asses if the hot flushes during the menopause are asociated to alterations inthe metabolism of nitric oxide, total antioxidant activity and other biochemical parameters. Toevaluate the effect of hormone replacement therapy (HRT) in the metabolism of nitric oxide,total antioxidant activity and biochemistry in menopausal women with and without hot flushes.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Experimental study. This study included 29 healthy menopausal womenwith hot flushes (12 with HRT) and 20 without them (6 with HRT), 45-55 years old, with durationof menopause ranging from 1 to 5 years. Control group included 14 fertile women. Determinationsof estradiol, nitrite-nitrate, total antioxidant activity and basic analytic, were performedbefore previous and after 4-6 month of HRT therapy.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Previously to HRT, hot flushes were associated to smaller level of total antioxidant activity(p < 0.05) in plasma, without differences in nitrite-nitrate concentrations. HRT was associatedto increase in total antioxidant activity level and nitrite-nitrate concentrations (p < 0.05)in menopausal women, with and without hot flushes.CONCLUSIONS: Hot flushes during the menopause indicate a high level of oxidative stress and ahigher cardiovascular risk. HRT decreased the oxidative stress level and increased the nitricoxide derivated metabolites in menopausal women with and without hot flushes.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:40 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Menopause and cardiovascular disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "R. Philosophe" 1 => "M.M. Seibel" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Clinical Issues" "fecha" => "1991" "volumen" => "2" "paginaInicial" => "441" "paginaFinal" => "451" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." 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