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array:23 [ "pii" => "S0025775300711869" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71186-9" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71186" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:50-1" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3448 "formatos" => array:3 [ "EPUB" => 11 "HTML" => 3286 "PDF" => 151 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300711870" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71187-0" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71187" "copyright" => "Elsevier España, S.L." 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Estudio de 301 casos de la zona centro y norte" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "50" "paginaFinal" => "51" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Carmen Garcés, Fernando Rodríguez Artalejo, Adalberto Serrano, José González Bonillo, Fatima Almagro, Juan Antonio Garrido, Manuel Zúñiga, Manuel de Oya" "autores" => array:8 [ 0 => array:3 [ "nombre" => "Carmen" "apellidos" => "Garcés" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Fernando Rodríguez" "apellidos" => "Artalejo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Adalberto" "apellidos" => "Serrano" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 3 => array:3 [ "nombre" => "José González" "apellidos" => "Bonillo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 4 => array:3 [ "nombre" => "Fatima" "apellidos" => "Almagro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 5 => array:3 [ "nombre" => "Juan Antonio" "apellidos" => "Garrido" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] ] ] 6 => array:3 [ "nombre" => "Manuel" "apellidos" => "Zúñiga" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff0035" ] ] ] 7 => array:4 [ "nombre" => "Manuel" "apellidos" => "de Oya" "email" => array:1 [ 0 => "moya@fjd.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:7 [ 0 => array:3 [ "entidad" => "Unidad de Lípidos Fundación Jiménez Díaz. Madrid" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Departamento de Medicina y Salud Publica. Universidad del País Vasco" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Centro de Salud. Portugalete. Vizcaya" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Centro Salud Santo Grial. Huesca" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Hospital de Guipúzcoa. San Sebastián" "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Hospital Arquitecto Marcide. El Ferrol" "etiqueta" => "<span class="elsevierStyleSup">f</span>" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Hospital Marqués de Valdecilla. Santander" "etiqueta" => "<span class="elsevierStyleSup">g</span>" "identificador" => "aff0035" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "**" "correspondencia" => "Correspondencia: Prof. M. de Oya. Unidad de Lípidos. Fundación Jiménez Díaz. Avda. Reyes Católicos 2. 280040 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical manifestations of heterozygous familial hipercholesterolaemia in Spain. Report of 301 cases from the central and northern areas" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-11-02" "fechaAceptado" => "1999-11-12" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec221134" "palabras" => array:2 [ 0 => "Hipercolesterolemia familiar heterozigota" 1 => "Xantomas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Caracterizar las manifestacionesclínicas de la hipercolesterolemia familiar(HF) en España</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Serie de 301 casos conHF procedentes del centro y norte de España.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Con un colesterol medio (DE)de 346 (58) mg/dl sólo el 7,6% de los casospresenta xantomas y el 20% cardiopatíaisquémica (CI). En el 51% existe el antecedentefamiliar de CI.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En desacuerdo con la bibliografíainternacional, los xantomas son muyinfrecuentes en la HF en España, por lo quela sospecha del diagnóstico debe basarse enotras manifestaciones. La elevada presenciadel antecedente familiar de CI convierteeste aspecto en un marcador útil para eldiagnóstico y la prevención.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Rationale</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To characterize clinical manifestationsof familial hypercholesterolemia(FH) in Spain.</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">A group of 301 cases ofFH from central and north regions of Spain.RESULTS: With a mean (SD) colesterol levelof 346 (58) mg/dl, only 7.6% of the patientshave xanthomas and 20% ischaemicheart disease. 51% have a familial historyof ischaemic heart disease.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Different from the results of literature,xanthomas are very infrequent inFH in Spain, so diagnosis should be suspectedfrom other data. The high prevalence offamilial history of ischaemic heart diseasesupports the usefulness of this feature as amarker for diagnosis and prevention.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic basis of lipoprotein disorders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "M. Dammerman" 1 => "J.L. 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