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array:23 [ "pii" => "S0025775301717460" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71746-0" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71746" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2001" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:125-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1688 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 1389 "PDF" => 292 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775301717472" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71747-2" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71747" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:129-32" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2290 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 2052 "PDF" => 233 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Relación del consumo de alimentos y nutrientes con el hábito tabáquico" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "129" "paginaFinal" => "132" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Food consumption and nutrient intake in relation to smoking" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Lluís Serra Majem, Blanca Román Viñas, Lourdes Ribas Barba, Josep M.Ramony, Gonçal Lloveras" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Lluís" "apellidos" => "Serra Majem" ] 1 => array:2 [ "nombre" => "Blanca" "apellidos" => "Román Viñas" ] 2 => array:2 [ "nombre" => "Lourdes" "apellidos" => "Ribas Barba" ] 3 => array:2 [ "nombre" => "Josep" "apellidos" => "M.Ramony" ] 4 => array:2 [ "nombre" => "Gonçal" "apellidos" => "Lloveras" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717472?idApp=UINPBA00004N" "url" => "/00257753/0000011600000004/v1_201307291415/S0025775301717472/v1_201307291415/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0025775301717459" "issn" => "00257753" "doi" => "10.1016/S0025-7753(01)71745-9" "estado" => "S300" "fechaPublicacion" => "2001-01-01" "aid" => "71745" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2001;116:121-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3433 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 2469 "PDF" => 958 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Utilidad diagnóstica del cuestionario Alcohol Use Disorders Identification Test (AUDIT) para detectar el consumo de alcohol de riesgo en atención primaria" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "121" "paginaFinal" => "124" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Diagnostic usefulness of Alcohol Use Disorders Identification Test (AUDIT) for detecting hazardous alcohol consumption in primary care settings" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "Alfredo Gómez Arnáiz, José Alberto Aguiar Bautista, José Manuel Santana Montesdeoca, Ascensión Manuel Santana Montesdeoca Jorrín Morenoy" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Alfredo" "apellidos" => "Gómez Arnáiz" ] 1 => array:2 [ "nombre" => "José" "apellidos" => "Alberto Aguiar Bautista" ] 2 => array:2 [ "nombre" => "José" "apellidos" => "Manuel Santana Montesdeoca" ] 3 => array:2 [ "nombre" => "Ascensión" "apellidos" => "Manuel Santana Montesdeoca Jorrín Morenoy" ] ] ] 1 => array:2 [ "autoresLista" => "Alicia Conde Martel, Pedro Betancor León" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Alicia" "apellidos" => "Conde Martel" ] 1 => array:2 [ "nombre" => "Pedro" "apellidos" => "Betancor León" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775301717459?idApp=UINPBA00004N" "url" => "/00257753/0000011600000004/v1_201307291415/S0025775301717459/v1_201307291415/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Riesgo de transmisión del virus de la hepatitis B de donantes de hígado anti-HBc positivos" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "125" "paginaFinal" => "128" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "Rafael Bárcena Marugán, S. García Garzón, A. López San Román, E. Peña González, A. García Plaza" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Rafael" "apellidos" => "Bárcena Marugán" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "S." "apellidos" => "García Garzón" ] 2 => array:2 [ "nombre" => "A." "apellidos" => "López San Román" ] 3 => array:2 [ "nombre" => "E." "apellidos" => "Peña González" ] 4 => array:2 [ "nombre" => "A." "apellidos" => "García Plaza" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicios de Gastroenterología. Hospital Ramón y Cajal. Madrid" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondence: Servicio de Gastroenterología. Hospital Ramón y Cajal. Ctra. de Colmenar, km 9,1. 28034 Madrid." ] ] ] 1 => array:3 [ "autoresLista" => "R. Nash, R. Férnandez Muñoza, M. Mateosa" "autores" => array:3 [ 0 => array:3 [ "nombre" => "R." "apellidos" => "Nash" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Férnandez Muñoza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "M." "apellidos" => "Mateosa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Microbiología y Virología. Hospital Ramón y Cajal. Madrid" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Risk of hepatitis B virus transmission from hepatitis B core antibody-positive liver donors" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec220781" "palabras" => array:7 [ 0 => "Hepatitis B" 1 => "Trasplante hepático" 2 => "Anti-HBc" 3 => "Anti-HBs" 4 => "Donantes" 5 => "Receptores" 6 => "Transmisión" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec220782" "palabras" => array:7 [ 0 => "Hepatitis B" 1 => "Liver transplant" 2 => "Anti-HBc" 3 => "Anti-HBs" 4 => "Donors" 5 => "Recipients" 6 => "Transmission" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Estudiar el riesgo de transmitir el virus de la hepatitis B (VHB) a los receptores dehígados de donantes AgHBs negativos y anti-HBc positivos.</p> <span class="elsevierStyleSectionTitle">Pacientes y método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se han analizado retrospectivamente los marcadores séricos del VHB (MHB) (AgHBs, anti-HBc y anti-HBs) de 43 donantes, junto con los 41 receptores de estos órganos. La determinación de MHB se realizó por ELISA, y el ADN del VHB por técnica de hibridación molecular.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Trece sueros de donantes (30,2%) presentaron algún MHB: 6 anti-HBc y anti-HBs(13,9%), 4 anti-HBc (9%) y tres anti-HBs (6,9%). De los receptores que recibieron un injertosin MHB, ninguno desarrolló infección después del trasplante de hígado. De los 13 receptores de órganos con MHB, 9 han sido controlados durante 39 (DE 17) meses. Los 5 receptores de un injerto anti-HBc positivo, con anti-HBs o sin él, y que no presentaban MHB desarrollaron hepatitis B (100%). Los dos receptores de órganos anti-HBs positivos únicamente y sin MHB no desarrollaron infección (0%). Entre los receptores 15 tenían algún MHB antes del trasplante de hígado (31,7%); 5 de ellos tenían anti-HBs positivo antes del trasplante. Los dos receptores de este grupo que recibieron un injerto anti-HBc positivo no desarrollaron infección (0%).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En este estudio la prevalencia de MHB entre los donantes y receptores es del 30,2 y del 31,7%, respectivamente. Los injertos anti-HBc positivos con anti-HBs o sin él transmitieronla enfermedad en el 100% de los receptores. La presencia de anti-HBs en el receptor protegió de la infección. Los injertos únicamente positivos para anti-HBs no ransmitieron la enfermedad.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To study the hepatitis B virus (HBV) transmission from donors HBsAg–/AntiHBc+ to liver transplant recipients.</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We studied retrospectively the HBV serological markers in 43 donors from our center and also the serological condition of the 41 recipients. The HBV serological markers were analyzed by ELISA and HBV DNA was detected by hybridation assays.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">13 donors samples showed some HBV serological markers: 6 anti-HBc and anti- HBs (13.9%), 4 anti-HBc (9%) and 3 anti- HBs (6.9%). There were no cases of hepatitis B amongliver recipients from donors with negative serological markers. Among the 13 recipients with HBV serological markers, 9 were followed during 39 (SD 17) months. The 5 recipients with no HBV markers, who received an anti- HBc+ with or without anti- HBs (100%) developed hepatitis B. The two liver recipients with anti-HBs solely, did not developed infection (0%). Of the 41 recipients, 15 had some HBV markers before transplant and two of them received an anti- HBc+ and did not develop the infection (0%).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">In our study, the prevalence of serological HBV infection in donors and recipients was of 30.2 and 31.7%, respectively. Anti-HBc with or without anti-HBs donors transmitted the HBV infection in all the cases (100%) to the susceptible recipients. The presence of anti- HBs in recipients protected these against the infection. 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