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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:128-31" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1577 "formatos" => array:3 [ "EPUB" => 5 "HTML" => 1478 "PDF" => 94 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Trasplante de células progenitoras hematopoyéticas como tratamiento de rescate en pacientes con linfomas no hodgkinianos agresivos" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "128" "paginaFinal" => "131" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Hematopoietic stem cell transplantation as salvage treatment in patients with aggresive non-Hodgkin's lymphoma" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "Reyes Arranz, César Sanz-Rodríguez, Francisco J. Pajuelo, Carmen Martínez Chamorro, José M<span class="elsevierStyleSup">a</span> Fernández Rañada." "autores" => array:5 [ 0 => array:2 [ "nombre" => "Reyes" "apellidos" => "Arranz" ] 1 => array:2 [ "nombre" => "César" "apellidos" => "Sanz-Rodríguez" ] 2 => array:2 [ "nombre" => "Francisco J." "apellidos" => "Pajuelo" ] 3 => array:2 [ "nombre" => "Carmen" "apellidos" => "Martínez Chamorro" ] 4 => array:2 [ "nombre" => "José M<span class="elsevierStyleSup">a</span>" "apellidos" => "Fernández Rañada." ] ] ] 1 => array:2 [ "autoresLista" => "Agustín Acevedo, Guillermo Pérez" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Agustín" "apellidos" => "Acevedo" ] 1 => array:2 [ "nombre" => "Guillermo" "apellidos" => "Pérez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712176?idApp=UINPBA00004N" "url" => "/00257753/0000011400000004/v1_201307291355/S0025775300712176/v1_201307291355/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Utilidad de la prueba de ejercicio cardiopulmonar en pacientes con miopatía mitocondrial" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "121" "paginaFinal" => "127" ] ] "autores" => array:2 [ 0 => array:4 [ "autoresLista" => "J. Fernández, T. Montemayor, J. Castillo" "autores" => array:3 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Fernández" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "T." "apellidos" => "Montemayor" ] 2 => array:2 [ "nombre" => "J." "apellidos" => "Castillo" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neumología. Hospital Virgen del Rocío. Sevilla." ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Unidad de Neumología. Hospital Costa del Sol. Ctra. Nacional 340, km. 187. 29600 Marbella. Málaga." ] ] ] 1 => array:3 [ "autoresLista" => "J. Bautista, R. Márquez, L. Jiménezb, J. Arenas, Y. Campos" "autores" => array:5 [ 0 => array:3 [ "nombre" => "J." "apellidos" => "Bautista" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 1 => array:3 [ "nombre" => "R." "apellidos" => "Márquez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] ] ] 2 => array:3 [ "nombre" => "L." "apellidos" => "Jiménezb" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] ] ] 3 => array:3 [ "nombre" => "J." "apellidos" => "Arenas" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] ] 4 => array:3 [ "nombre" => "Y." "apellidos" => "Campos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Neurología Hospital Virgen del Rocío. Sevilla." "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] 1 => array:3 [ "entidad" => "Departamento de Bioquímica.Hospital Virgen del Rocío. Sevilla" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] 2 => array:3 [ "entidad" => "<span class="elsevierStyleItalic">Unidad de Investigación Neuromuscular. Facultad de Medicina. Universidad Complutense de Madrid</span>" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Role of cardiopulmonary exercise test in patients with mitochondrial myopathies" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1999-07-08" "fechaAceptado" => "1999-09-11" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Miopatías mitocondriales" "identificador" => "xpalclavsec220511" "palabras" => array:3 [ 0 => "Prueba de esfuerzo" 1 => "Umbral láctico" 2 => "Miopatías metabólicas" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Las pruebas de ejercicio cardiopulmonar han sido utilizadas en el diagnóstico delas miopatías metabólicas. Se desconoce si existe un patrón de respuesta anormal en las miopatíasmitocondriales con afectación leve y la utilidad de esta técnica en el diagnóstico de sospechainicial.</p> <span class="elsevierStyleSectionTitle">Pacientes y métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo en 26 pacientes con miopatías mitocondriales (MM)(15 varones y 11 mujeres) y un grupo control de 14 voluntarios sanos (9 varones y 5 mujeres)de características antropométricas similares. Realizamos pruebas de función respiratoria yprueba de ejercicio en tapiz rodante con determinaciones venosas seriadas de lactato, piruvato,cuerpos cetónicos, ácidos grasos libres y creatincinasa.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con miopatías mitocondriales presentaban limitación al ejercicio,con valores menores de potencia máxima (MM = 143 [47] vatios, C = 187 [40] vatios,p = 0,006), consumo de oxígeno máximo (MM = 27 [8] ml/kg/min, C = 40 [7] ml/kg/min, p =0,001) y pulso de oxígeno (MM = 11 [3] ml/latido, C = 14 [3] ml/latido, p = 0,006). La frecuenciacardíaca en relación con el consumo de oxígeno fue mayor y el umbral anaerobio fuemás precoz en el grupo MM (MM = 48% [14], C = 62% [12], p = 0,01). Los pacientes conpredominio de lípidos en la biopsia muscular (n = 15) presentaban un consumo de oxígeno máximomás bajo. Las curvas de cuerpos cetónicos, ácidos grasos libres y creatincinasa fueron similaresen ambos grupos. La prueba de esfuerzo fue anormal en 17 de 26 pacientes. La sensibilidadde la prueba para el consumo de oxígeno máximo fue de 0,65.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La mayoría de los pacientes con miopatía mitocondrial leve presentan una pruebade ejercicio cardiopulmonar anormal, siendo por tanto una prueba útil en el estudio inicial dedetección de estos pacientes.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Exercise tests has been used in the diagnosis of metabolic myopathies. If there isan anormal response pattern in mild mitochondrial myopathy (MM) and her role in the initialsuspect diagnostic is unknown.</p> <span class="elsevierStyleSectionTitle">Subjects and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Prospective study of 26 patients with mitochondrial myopathy (15 men,11 women) and a control group of 14 sedentary volunteers (9 men, 5 woman) with similar antropometriccharacteristics. We have maked pulmonary function tests and treadmill exercisewith serial venous sampling of blood lactate, piruvate, ketone bodies, free fatty acids and creatinkinase.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Patients with MM showed exercise limitation with lower maximal power (MM = 143[47] vatts, C = 187 [40] vatts, p = 0.006), maximal oxygen uptake (MM = 27 [8] ml/min/kg, C= 40 [7] ml/min/kg, p = 0.001) and maximal oxygen pulse (MM = 11 [3] ml/beat, C = 14 [3]ml/beat, p = 0.006). For the same oxygen uptake the heart rate was higher and the anaerobicthreshold was earlier in MM patients (MM = 48% [14], C = 62% [12], p = 0.01). We found aconsiderable slower maximal oxygen uptake in patients with lipid increase in muscle biopsy (n= 15). Acetoacetate curves, ß-hydroxybutirate, free fatty acids and creatinkinase were similar inboth groups. The exercise test was pathologic in 17/26 of the patients. The sensitivity of theexercise test for maximal oxygen uptake was 0.65.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The cardiopulmonary exercise test is a uselful test in the suspect initial diagnostic ofpatients with mild mitochondrial myopathy because the majority of patients show a pathologic test.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mitochondrial encephalomyopathies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "P.L. Peterson" 1 => "M.E. Martens" 2 => "C.P. 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2024 Octubre | 1 | 7 | 8 |
2024 Septiembre | 0 | 1 | 1 |
2024 Agosto | 0 | 3 | 3 |
2024 Julio | 0 | 4 | 4 |
2024 Junio | 0 | 1 | 1 |
2024 Abril | 0 | 6 | 6 |
2024 Marzo | 0 | 6 | 6 |
2024 Febrero | 0 | 6 | 6 |
2024 Enero | 0 | 5 | 5 |
2023 Diciembre | 0 | 16 | 16 |
2023 Noviembre | 0 | 4 | 4 |
2023 Octubre | 0 | 3 | 3 |
2023 Septiembre | 0 | 4 | 4 |
2023 Agosto | 0 | 23 | 23 |
2023 Julio | 0 | 4 | 4 |
2023 Junio | 0 | 2 | 2 |
2023 Marzo | 3 | 5 | 8 |
2023 Febrero | 0 | 2 | 2 |
2022 Noviembre | 0 | 1 | 1 |
2022 Octubre | 0 | 7 | 7 |
2022 Septiembre | 0 | 3 | 3 |
2022 Agosto | 0 | 1 | 1 |
2022 Junio | 0 | 2 | 2 |
2022 Abril | 0 | 2 | 2 |
2022 Enero | 0 | 1 | 1 |
2021 Diciembre | 0 | 2 | 2 |
2021 Junio | 0 | 3 | 3 |
2021 Febrero | 0 | 1 | 1 |
2021 Enero | 0 | 1 | 1 |
2020 Diciembre | 0 | 1 | 1 |
2020 Agosto | 0 | 3 | 3 |
2020 Junio | 0 | 3 | 3 |
2020 Mayo | 0 | 5 | 5 |
2020 Marzo | 0 | 1 | 1 |
2020 Febrero | 0 | 1 | 1 |
2020 Enero | 0 | 6 | 6 |
2019 Diciembre | 0 | 6 | 6 |
2019 Noviembre | 0 | 1 | 1 |
2019 Octubre | 0 | 2 | 2 |
2019 Septiembre | 0 | 1 | 1 |
2019 Julio | 0 | 3 | 3 |
2019 Junio | 0 | 7 | 7 |
2019 Mayo | 0 | 26 | 26 |
2019 Abril | 1 | 2 | 3 |
2017 Octubre | 3 | 5 | 8 |
2017 Septiembre | 3 | 10 | 13 |
2017 Agosto | 7 | 10 | 17 |
2017 Julio | 6 | 14 | 20 |
2017 Junio | 11 | 20 | 31 |
2017 Mayo | 11 | 5 | 16 |
2017 Abril | 2 | 1 | 3 |
2017 Marzo | 24 | 22 | 46 |
2017 Febrero | 27 | 2 | 29 |
2017 Enero | 10 | 6 | 16 |
2016 Diciembre | 28 | 2 | 30 |
2016 Noviembre | 39 | 2 | 41 |
2016 Octubre | 54 | 2 | 56 |
2016 Septiembre | 21 | 8 | 29 |
2016 Agosto | 11 | 0 | 11 |
2016 Julio | 14 | 0 | 14 |
2016 Junio | 23 | 0 | 23 |
2016 Mayo | 22 | 3 | 25 |
2016 Abril | 32 | 0 | 32 |
2016 Marzo | 25 | 1 | 26 |
2016 Febrero | 20 | 2 | 22 |
2016 Enero | 19 | 0 | 19 |
2015 Diciembre | 17 | 0 | 17 |
2015 Noviembre | 29 | 0 | 29 |
2015 Octubre | 27 | 0 | 27 |
2015 Septiembre | 27 | 0 | 27 |
2015 Agosto | 18 | 0 | 18 |
2015 Julio | 12 | 0 | 12 |
2015 Junio | 19 | 0 | 19 |
2015 Mayo | 15 | 0 | 15 |
2015 Abril | 18 | 0 | 18 |
2015 Marzo | 21 | 0 | 21 |
2015 Febrero | 24 | 0 | 24 |
2015 Enero | 9 | 0 | 9 |
2014 Diciembre | 18 | 0 | 18 |
2014 Noviembre | 10 | 0 | 10 |
2014 Octubre | 9 | 0 | 9 |
2014 Septiembre | 10 | 0 | 10 |
2014 Agosto | 11 | 0 | 11 |
2014 Julio | 10 | 0 | 10 |
2014 Junio | 7 | 0 | 7 |
2014 Mayo | 4 | 0 | 4 |
2014 Abril | 3 | 0 | 3 |
2014 Marzo | 9 | 0 | 9 |
2014 Febrero | 9 | 0 | 9 |
2014 Enero | 7 | 0 | 7 |
2013 Diciembre | 3 | 0 | 3 |
2013 Noviembre | 7 | 0 | 7 |
2013 Octubre | 21 | 0 | 21 |
2013 Septiembre | 5 | 0 | 5 |
2013 Agosto | 2 | 0 | 2 |
2013 Julio | 3 | 0 | 3 |
2000 Febrero | 1357 | 0 | 1357 |