Originales
Estimación de la prevalencia de infección por VIH-1 en la embarazada y efectividad de la zidovudina administrada durante la gestación en la prevención de la transmisión vertical
Estimate of the HIV-1 prevalence in pregnant women and effectiveness of zidovudine administered during pregnancy in reducing perinatal transmission
Leído
3112
Vecesse ha leído el artículo
247
Total PDF
2865
Total HTML
Compartir estadísticas
array:23 [ "pii" => "S0025775300712711" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71271-1" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71271" "copyright" => "Elsevier España, S.L.. Todos los derechos reservados" "copyrightAnyo" => "2000" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:286-91" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2982 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 2863 "PDF" => 113 ] ] "itemSiguiente" => array:18 [ "pii" => "S0025775300712723" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71272-3" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71272" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:292-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 3695 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 3539 "PDF" => 150 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales breves</span>" "titulo" => "Análisis clínico de la tromboembolia pulmonar no sospechada en el servicio de urgencias" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "292" "paginaFinal" => "293" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Clinical analysis of the unsuspected pulmonary embolism in the emergency department" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "Pere Tudela, Antonia Segura, Juan Valencia, Anna Carreres" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Pere" "apellidos" => "Tudela" ] 1 => array:2 [ "nombre" => "Antonia" "apellidos" => "Segura" ] 2 => array:2 [ "nombre" => "Juan" "apellidos" => "Valencia" ] 3 => array:2 [ "nombre" => "Anna" "apellidos" => "Carreres" ] ] ] 1 => array:2 [ "autoresLista" => "Ester Davant, Manuel Monreal" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Ester" "apellidos" => "Davant" ] 1 => array:2 [ "nombre" => "Manuel" "apellidos" => "Monreal" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712723?idApp=UINPBA00004N" "url" => "/00257753/0000011400000008/v1_201307291447/S0025775300712723/v1_201307291447/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S002577530071270X" "issn" => "00257753" "doi" => "10.1016/S0025-7753(00)71270-X" "estado" => "S300" "fechaPublicacion" => "2000-01-01" "aid" => "71270" "copyright" => "Elsevier España, S.L." "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2000;114:281-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2007 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 1852 "PDF" => 149 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Monitorización de la enfermedad mínima residual mediante detección conjunta de los reordenamientos <span class="elsevierStyleItalic">PML/RARα</span> y <span class="elsevierStyleItalic">RARα/PML</span> en la leucemia promielocítica aguda" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "281" "paginaFinal" => "285" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Monitoring of minimal residual disease by combined detection of PML/RARα and RARα/PML rearrangements in acute promyelocytic leukemia" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Pascual Bolufer,, Eva Barragán, Miguel Ángel Sanz, Guillermo Martín, Enrique Lerma, Esperanza Afán de Ribera" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Pascual" "apellidos" => "Bolufer," ] 1 => array:2 [ "nombre" => "Eva" "apellidos" => "Barragán" ] 2 => array:2 [ "nombre" => "Miguel" "apellidos" => "Ángel Sanz" ] 3 => array:2 [ "nombre" => "Guillermo" "apellidos" => "Martín" ] 4 => array:2 [ "nombre" => "Enrique" "apellidos" => "Lerma" ] 5 => array:2 [ "nombre" => "Esperanza" "apellidos" => "Afán de Ribera" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S002577530071270X?idApp=UINPBA00004N" "url" => "/00257753/0000011400000008/v1_201307291447/S002577530071270X/v1_201307291447/es/main.assets" ] "es" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Estimación de la prevalencia de infección por VIH-1 en la embarazada y efectividad de la zidovudina administrada durante la gestación en la prevención de la transmisión vertical" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "286" "paginaFinal" => "291" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "José Tomás Ramos Amador, Jesús Ruiz Contreras, Rafael Bastero, Carmen Barrio, Pilar Moreno, Rafael Delgado, Eloy Muñoz, Jesús Jiménez" "autores" => array:8 [ 0 => array:3 [ "nombre" => "José Tomás" "apellidos" => "Ramos Amador" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Jesús Ruiz" "apellidos" => "Contreras" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 2 => array:3 [ "nombre" => "Rafael" "apellidos" => "Bastero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] ] ] 3 => array:3 [ "nombre" => "Carmen" "apellidos" => "Barrio" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] ] ] 4 => array:3 [ "nombre" => "Pilar" "apellidos" => "Moreno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] ] 5 => array:3 [ "nombre" => "Rafael" "apellidos" => "Delgado" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] ] ] 6 => array:3 [ "nombre" => "Eloy" "apellidos" => "Muñoz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff00020" ] ] ] 7 => array:3 [ "nombre" => "Jesús" "apellidos" => "Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff00020" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Unidad de Inmunodeficiencias, Madrid" "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff00005" ] 1 => array:3 [ "entidad" => "Servicio de Neonatología. Departamento de Pediatría, Madrid" "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff00010" ] 2 => array:3 [ "entidad" => "Servicio de Microbiología, Madrid" "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff00015" ] 3 => array:3 [ "entidad" => "Departamento de Obstetricia y Ginecología. Hospital 12 de Octubre. Madrid" "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff00020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Dr. J.T. Ramos Amador. Unidad de Inmunodeficiencias. Hospital 12 de Octubre. Carretera de Andalucía, km 5,4. 28041 Madrid." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Estimate of the HIV-1 prevalence in pregnant women and effectiveness of zidovudine administered during pregnancy in reducing perinatal transmission" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1998-01-07" "fechaAceptado" => "1999-09-02" "PalabrasClave" => array:1 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec221299" "palabras" => array:3 [ 0 => "VIH-1" 1 => "Zidovudina" 2 => "Transmisión vertical" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">: A pesar de la eficacia probada de la zidovudina (ZDV) administrada a la embarazada enla disminución de la transmisión vertical del VIH-1, existen importantes dudas sobre la efectividad yel cumplimiento en la práctica clínica. Los objetivos han sido determinar la efectividad de la ZDV duranteel embarazo a las mujeres con infección por VIH en la reducción de la transmisión vertical (TV)y analizar la tendencia en el tiempo de la prevalencia de infección y de los casos identificados precozmente.</p> <span class="elsevierStyleSectionTitle">Pacientes Y Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">: Se han seleccionado los pares de madres/hijos seguidos prospectivamente desdeel nacimiento, en el período comprendido entre el 1 de enero de 1987 y el 30 de octubre de 1997.Se ha considerado infectado al niño con anticuerpos positivos a partir de los 18 meses, o al menos 2determinaciones mediante reacción en cadena de la polimerasa (PCR) positivas en los primeros 3 mesesde vida.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">: Se han identificado 229 madres y 248 niños. Se administró ZDV a 34 madres en el embarazocon una media (DE) de 4,7 (3,1) meses. El valor medio de CD4 fue de 465 (261) células ×10<span class="elsevierStyleSup">6</span>/l. Las únicas variables asociadas con un mayor riesgo de transmisión fueron el tiempo de roturade bolsa (mediana en transmisoras 6 h, mediana en no transmisoras 1,04 h; p = 0,023) y el tratamientocon ZDV. De las madres tratadas durante el embarazo sólo un niño resultó infectado (TV2,9%), frente a 37 niños en las no tratadas (TV 17,5%) (p = 0,029; odds ratio [OR]: 0,14; intervalode confianza [IC] del 95%: 0,07-0,92). La prevalencia estimada de infección por VIH-1 en mujeresgestantes en nuestra área se sitúa en torno al 0,39% (IC del 95%: 0,34-0,45). En los primeros 5años del período de estudio, 14 niños (9,7%) fueron identificados como seropositivos después del períodoneonatal, en comparación a sólo 3 a partir de 1992 (p = 0,034).</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">: En este estudio, la prevalencia estimada de infección por VIH-1 en mujeres embarazadases elevada. El tratamiento con ZDV durante el embarazo se asocia a una disminución en la transmisiónvertical del VIH-1. Es posible que la disponibilidad de esta medida haya contribuido a la mayoridentificación de las embarazadas seropositivas observada en el tiempo.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">: Despite the proven efficacy of zidovudine (ZDV) for reducing perinatal transmission ofHIV-1, questions remain about its implementation and effectiveness in routine practice. The aimsof this study were to assess the impact of ZDV administered during pregnancy in preventing perinatalHIV-1 transmission, and to determine the proportion of early identification of maternal HIV-1 infectionover time.</p> <span class="elsevierStyleSectionTitle">Patients and Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">: We prospectively followed from birth a cohort of children born between1/1/1987 and 31/10/1997 to HIV-1-infected mothers. Infant infection status was assessed by followupbeyond 18 months or HIV-PCR up to 3 months of age.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">: 229 mothers and 248 infants were identified in the cohort. ZDV was administered duringpregnancy as monotherapy to 34 mothers for a mean of 4,7 (3,1) months prior to delivery. There wereno differences in baseline characteristics between the treated and untreated groups. Mean (SD) CD4cell count was 465 (261) cells × 10<span class="elsevierStyleSup">6</span>/l. Factors associated with transmission were a more prolongedtime of rupture of obstetric membranes (median 6 vs 1,04 hours; p = 0,023) and ZDV treatment.Among the ZDV-treated mothers only one child was infected (2,9%), whereas 37 children born to 212untreated women became infected. (OR: 0,14; 95% CI: 0,07-0,92). The estimated prevalence ofHIV-1 in pregnant women in our area is about 0,39% (95% CI: 0,34-0,45). From 1987 to 1991,9,7% of infected women were nor identified at the perinatal period, as compared to 2,5% in the last5 years of the study period (p = 0,034).</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">: In this study, the estimated prevalence of HIV-1 infection is high. ZDV during pregnancyis significantly associated with a decrease in perinatal transmission in our setting. The awareness ofan effective treatment might have contributed to the increased identification of HIV-infected mothersprior to delivery observed over time in our cohort of children born to HIV-infected mothers.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Referencias Bibliográficas" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:37 [ 0 => array:3 [ "identificador" => "bib00005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vigilancia epidemiólogica del sida en España" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Boletín epidemiológico de la comunidad de Madrid." "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Informe trimestral n. °" "fecha" => "1997" "volumen" => "3" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib00010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Current concepts: mother to child transmission of the human immunodeficiency virus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "C. Peckham" 1 => "D. Gibb" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199508033330506" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1995" "volumen" => "333" "paginaInicial" => "297" "paginaFinal" => "302" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7596374" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib00015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pediatric HIV infection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "G. Scarlatti" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(95)11030-5" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1996" "volumen" => "348" "paginaInicial" => "863" "paginaFinal" => "868" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8826814" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib00020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology and determinants of vertical HIV transmission" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "L. Mofenson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Semin Pediatr Infect Dis" "fecha" => "1994" "volumen" => "5" "paginaInicial" => "252" "paginaFinal" => "255" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib00025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relation of the course of HIV infection in children to the severity of the disease in their mothers at delivery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Blanche" 1 => "M.J. Mayaux" 2 => "C. Rouzioux" 3 => "J.P. Teglas" 4 => "G. Firtion" 5 => "F. Monpoux" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199402033300502" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1994" "volumen" => "330" "paginaInicial" => "308" "paginaFinal" => "312" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7904046" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib00030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of levels of maternal HIV-1 RNA associated with risk of perinatal transmission" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.E. Dickover" 1 => "E.M. Garratly" 2 => "S.A. Herman" 3 => "M.S. Sim" 4 => "S. Plaeger" 5 => "P.J. Boyer" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1996" "volumen" => "275" "paginaInicial" => "599" "paginaFinal" => "605" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8594240" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib00035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Vertical transmission of HIV-1: maternal immune status and obstetric factors" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "European Collaborative Study." "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "1996" "volumen" => "10" "paginaInicial" => "1675" "paginaFinal" => "1681" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8970688" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib00040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Obstetrical factors and the transmission of human immunodeficicency virus type 1 from" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.H. Landesman" 1 => "L.A. Kalish" 2 => "D.N. Burns" 3 => "H. Minkoff" 4 => "H.E. Fox" 5 => "C. Zorrilla" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "mother to child N Engl J Med" "fecha" => "1996" "volumen" => "334" "paginaInicial" => "1617" "paginaFinal" => "1623" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib00045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mode of delivery and gestational age influence perinatal HIV-1 transmission" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.A. Tovo" 1 => "M. De Martino" 2 => "C. Gabiano" 3 => "L. Galli" 4 => "N. Capello" 5 => "E. Ruga" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Acq Immune Def Syndr Hum Retrovirol" "fecha" => "1996" "volumen" => "11" "paginaInicial" => "88" "paginaFinal" => "94" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib00050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Timing of maternal-infant HIV transmission: associations between intrapartum factors and early polymerase chain reaction results" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "L. Kuhn" 1 => "E.J. Abrams" 2 => "P.B. Matheson" 3 => "P.A. Thomas" 4 => "G. Lambert" 5 => "M. Bamji" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "1997" "volumen" => "11" "paginaInicial" => "429" "paginaFinal" => "435" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9084789" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib00055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "and the Working Group on HIV-1 vertical transmission in Catalonia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "A. Maguire" 1 => "E. Sánchez" 2 => "C. Fortuny" 3 => "J. Casabona" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Potential risk factors for vertical HIV-1 transmission in Catalonia, Spain: the protective role of Cesarean section. AIDS" "fecha" => "1997" "volumen" => "11" "paginaInicial" => "1851" "paginaFinal" => "1857" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib00060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neonatal predictors of infection status and early death among 332 infants at risk of HIV-1 infection monitored prospectively from birth" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.J. Abrams" 1 => "P. Matheson" 2 => "P.A. Thomas" 3 => "D. Thea" 4 => "K. Krasinski" 5 => "G. Lambert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Pediatrics" "fecha" => "1995" "volumen" => "96" "paginaInicial" => "451" "paginaFinal" => "458" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7651777" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib00065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduction of maternal-infant transmission of human immunodeficicency virus type 1 with zidovudine treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.M. Connor" 1 => "R.S. Sperling" 2 => "R. Gelber" 3 => "P. Kiselev" 4 => "G. Scott" 5 => "M.J. O'Sullivan" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199411033311801" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1994" "volumen" => "331" "paginaInicial" => "1173" "paginaFinal" => "1180" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7935654" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib00070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maternal genotypic zidovudine resistance and infrequent failure of zidovudine therapy to prevent perinatal transmission of HIV-1 in pediatric AIDS Clinical trial Group Protocol 076" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.S. Eastman" 1 => "D.E. Shapiro" 2 => "R.W. Coombs" 3 => "G.D. Mc-Sherry" 4 => "P. Britto" 5 => "S.A. Herman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "J Infect Dis" "fecha" => "1998" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib00075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Efficacy of antenatal zidovudine in reducing perinatal transmission of human immunodeficicency virus type 1" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.B. Matheson" 1 => "E.J. Abrams" 2 => "P. Thomas" 3 => "M.A. Hernan" 4 => "D.M. Thea" 5 => "G. Lambert" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "1995" "volumen" => "172" "paginaInicial" => "353" "paginaFinal" => "358" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7622877" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib00080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduction in the risk of vertical transmission of HIV-1 associated with treatment of pregnant women with orally administered zidovudine alone" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "B.J. Simpson" 1 => "D.E. Shapiro" 2 => "W.A. Andiman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Acq Immune Def Syndr Hum Retrovirol" "fecha" => "1997" "volumen" => "14" "paginaInicial" => "145" "paginaFinal" => "152" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib00085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quantitation of human immunodeficiency virus type 1 during pregnancy: relationship of viral titer to mother-tochild transmission and stability of viral load" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B. Weiser" 1 => "S. Nachman" 2 => "P. Tropper" 3 => "K.H. Viscosi" 4 => "R. Grimson" 5 => "G. Baxter" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Proc Natl Acad Sci" "fecha" => "1994" "volumen" => "91" "paginaInicial" => "8037" "paginaFinal" => "8041" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8058753" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib00090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maternal viral load, zidovudine treatment and the risk of transmission of human immunodeficicency virus from mothers to infant" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.S. Sperling" 1 => "D.E. Shapiro" 2 => "R.W. Coombs" 3 => "J.A. Todd" 4 => "S.A. Herman" 5 => "G.D. Mc Sherry" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM199611283352201" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "1996" "volumen" => "335" "paginaInicial" => "1621" "paginaFinal" => "1629" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8965861" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib00095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Viral load and HIV-1 vertical transmission" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "O. Coll" 1 => "M. Hernández" 2 => "C. Boucher" 3 => "C. Fortuny" 4 => "B.M. Tejada" 5 => "Y. Canet" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Acq Immune Def Syndr Hum Retrovirol" "fecha" => "1997" "volumen" => "14" "paginaInicial" => "26" "paginaFinal" => "30" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib000100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effect of maternal viral load on the risk of perinatal transmission of HIV-1" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "D.M. Thea" 1 => "R.W. Sketee" 2 => "K. Bornshlegel" 3 => "T. Brown" 4 => "S. Orloff" 5 => "P.B. Matheson" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "AIDS" "fecha" => "1997" "volumen" => "11" "paginaInicial" => "437" "paginaFinal" => "444" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9084790" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib000105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maternal virus load during pregnancy and mother to child transmission of human immunodeficicency virus type 1: the French perinatal cohort studies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.J. Mayaux" 1 => "E. Dussaix" 2 => "J. Isopet" 3 => "C. Rekacewicz" 4 => "L. Mandelbrot" 5 => "N.C. Vigneron" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "1997" "volumen" => "175" "paginaInicial" => "172" "paginaFinal" => "175" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8985214" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib000110" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Maternal HIV-1 viral load and vertical transmission of infection: the Ariel Project for the prevention of HIV transmission from mother to infant" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "Y. Cao" 1 => "P. Krogstad" 2 => "B.T. Korber" 3 => "R.A. Koup" 4 => "M. Muldoon" 5 => "C. Macken" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Nature Medicine" "fecha" => "1997" "volumen" => "3" "paginaInicial" => "549" "paginaFinal" => "552" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9142125" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib000115" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Zidovudine administered to women infected with human immunodeficicency virus type 1 and to their neonates reduces pediatric infection independent of an effect on levels of maternal virus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "L.F. Aleixo" 1 => "M.M. Goodenow" 2 => "J.W. Sleasman" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1997" "volumen" => "130" "paginaInicial" => "906" "paginaFinal" => "914" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9202612" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib000120" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Case control study of HIV seroconversion in health care workers after percutaneous exposure to HIV-infected blood. France, United Kingdom and United States, January 1988-August 1994" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Centers for Disease Control." "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "MMWR" "fecha" => "1995" "volumen" => "44" "paginaInicial" => "929" "paginaFinal" => "933" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8531910" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib000125" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of vertical transmission of human immunodeficicency virus type 1 by a commercial polymerase chain reaction assay" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Bermúdez" 1 => "P. Moreno" 2 => "R. Delgado" 3 => "J.T. Ramos" 4 => "J. Ruiz-Contreras" 5 => "A.R. Noriega" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Eur J Clin Microbiol Infect Dis" "fecha" => "1996" "volumen" => "15" "paginaInicial" => "327" "paginaFinal" => "330" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8781885" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib000130" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors predictive of maternal-fetal transmission of HIV-1. Preliminary analysis oz zidovudine guven during pregnancy and/or delivery" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P.J. Boyer" 1 => "M. Dillon" 2 => "M. Navaie" 3 => "A. Deveikes" 4 => "M. Keller" 5 => "S.H. O'Rourke" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1994" "volumen" => "271" "paginaInicial" => "1925" "paginaFinal" => "1930" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7911164" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib000135" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of pregnancy and zidovudine therapy on viral load in HIV-1-infected women" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A.J. Melvin" 1 => "S.K. Burchett" 2 => "D.H. Watts" 3 => "J. Hitti" 4 => "J.P. Hughes" 5 => "McLellan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Acq Immune Def Syndr" "fecha" => "1997" "volumen" => "14" "paginaInicial" => "232" "paginaFinal" => "236" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib000140" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Importance of maternal ZDV therapy in the reduction of perinatal transmission of HIV. Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections [resumen 379]" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.A. Fiscus" 1 => "A.A. Adimora" 2 => "V.J. Schoenbach" 3 => "W. Lim" 4 => "R. McKinney" 5 => "D. Rupar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Washington DC enero de" "fecha" => "1997" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib000145" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "for the French Pediatric HIV infection Study Group. Acceptability and impact of zidovudine prevention on mother to child transmission in France. Abstracts of the 4th Conference on Retroviruses and Opportunistic Infections [resumen 380]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "S. Blanche" 1 => "M.J. Mayaux" 2 => "L. Mandelbrot" 3 => "C. Rouzioux" 4 => "J.F. Delfraissy" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Washington DC enero de" "fecha" => "1997" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib000150" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Metabolism of 3'-azido-3'-deoxythymidine (ZDV) in human placental trophoblasts and Hofbaur cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "M. Quian" 1 => "T. Bui" 2 => "R.J.Y. Ho" 3 => "J.D. Unadkat" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Biochem Pharmacol" "fecha" => "1994" "volumen" => "48" "paginaInicial" => "383" "paginaFinal" => "389" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8053935" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib000155" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sociedad Española de Ginecología y Obstetricia, Asociación Española de Pediatría" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "O. Coll" 1 => "F. Omeñaca" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Recomendaciones sobre el uso de zidovudina (ZDV) en la prevención de la transmisión vertical del VIH. An Esp Ped" "fecha" => "1995" "volumen" => "42" "paginaInicial" => "74" "paginaFinal" => "77" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib000160" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Public Health Service Task Force recommendations for the use of antiretroviral drugs in pregnant women infected with HIV-1 for maternal health and for reducing perinatal HIV-1 transmission in the United States." "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "MMRW" "fecha" => "1998" "volumen" => "47" "paginaInicial" => "1" "paginaFinal" => "30" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib000165" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transmisión vertical del virus de la inmunodeficiencia humana: seis años de evolución (1987-1992)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Fortuny" 1 => "E. Sánchez" 2 => "O. Coll" 3 => "R. Jiménez González" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "1996" "volumen" => "107" "paginaInicial" => "530" "paginaFinal" => "532" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib000170" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Implementation of United States Public Health Service (USPHS) recommendations to prevent perinatal HIV transmission: pediatric HIV case surveillance, US Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy [resumen I-118]" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.L. Lindegreen" 1 => "P. Fleming" 2 => "S. Steinberg" 3 => "P. Wotley" 4 => "E. English" 5 => "R. Byers" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Toronto, septiembre de" "fecha" => "1997" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib000175" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The sensitivity of HIV-1 DNA polymerase chain reaction in the neonatal period and the relative contributions of intra-uterine and intra-partum transmission" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.T. Dunn" 1 => "C.D. Brandt" 2 => "A. Krivine" 3 => "S.A. Cassol" 4 => "P. Roques" 5 => "W. Borkowsky" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "AIDS" "fecha" => "1995" "volumen" => "9" "paginaInicial" => "7" "paginaFinal" => "11" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib000180" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis of infection with human immunodeficicency virus type 1 by a DNA polymerase chain reaction assay among infants enrolled in the Women and Infants Transmission Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.W. Bremer" 1 => "J.F. Lew" 2 => "K.P. Malobisky" 3 => "E. Cooper" 4 => "G.W. Hillyer" 5 => "J. Pitt" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Pediatr" "fecha" => "1996" "volumen" => "129" "paginaInicial" => "198" "paginaFinal" => "207" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8765616" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib000185" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antiretroviral therapy for HIV infection in 1997. Updated recommendations of the international AIDS society-USA panel" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C.J. Carpenter" 1 => "M.A. Fischl" 2 => "S.M. Hammer" 3 => "M.S. Hirsch" 4 => "D.M. Jacobsen" 5 => "D.A. Katzenstein" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "1997" "volumen" => "277" "paginaInicial" => "1962" "paginaFinal" => "1969" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9200638" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/00257753/0000011400000008/v1_201307291447/S0025775300712711/v1_201307291447/es/main.assets" "Apartado" => array:4 [ "identificador" => "24087" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Original breve" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/00257753/0000011400000008/v1_201307291447/S0025775300712711/v1_201307291447/es/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775300712711?idApp=UINPBA00004N" ]
| año/Mes | Html | Total | |
|---|---|---|---|
| 2024 Octubre | 0 | 3 | 3 |
| 2024 Septiembre | 0 | 1 | 1 |
| 2024 Julio | 0 | 2 | 2 |
| 2024 Junio | 0 | 1 | 1 |
| 2024 Mayo | 0 | 2 | 2 |
| 2024 Abril | 0 | 4 | 4 |
| 2024 Marzo | 0 | 8 | 8 |
| 2024 Febrero | 0 | 5 | 5 |
| 2024 Enero | 0 | 1 | 1 |
| 2023 Diciembre | 0 | 13 | 13 |
| 2023 Noviembre | 0 | 2 | 2 |
| 2023 Octubre | 0 | 2 | 2 |
| 2023 Septiembre | 0 | 1 | 1 |
| 2023 Julio | 0 | 6 | 6 |
| 2023 Junio | 0 | 1 | 1 |
| 2023 Mayo | 0 | 1 | 1 |
| 2023 Marzo | 2 | 3 | 5 |
| 2023 Febrero | 0 | 2 | 2 |
| 2023 Enero | 0 | 2 | 2 |
| 2022 Diciembre | 0 | 4 | 4 |
| 2022 Noviembre | 0 | 5 | 5 |
| 2022 Octubre | 0 | 5 | 5 |
| 2022 Septiembre | 0 | 34 | 34 |
| 2022 Agosto | 0 | 4 | 4 |
| 2022 Junio | 0 | 1 | 1 |
| 2022 Mayo | 0 | 6 | 6 |
| 2022 Marzo | 0 | 3 | 3 |
| 2021 Enero | 0 | 1 | 1 |
| 2020 Octubre | 0 | 1 | 1 |
| 2020 Septiembre | 0 | 1 | 1 |
| 2020 Agosto | 0 | 3 | 3 |
| 2020 Junio | 0 | 1 | 1 |
| 2020 Mayo | 0 | 3 | 3 |
| 2020 Marzo | 0 | 1 | 1 |
| 2020 Febrero | 0 | 1 | 1 |
| 2020 Enero | 0 | 2 | 2 |
| 2019 Diciembre | 0 | 7 | 7 |
| 2019 Noviembre | 0 | 2 | 2 |
| 2019 Agosto | 0 | 1 | 1 |
| 2019 Junio | 0 | 11 | 11 |
| 2019 Mayo | 0 | 25 | 25 |
| 2017 Octubre | 7 | 2 | 9 |
| 2017 Septiembre | 6 | 2 | 8 |
| 2017 Agosto | 5 | 4 | 9 |
| 2017 Julio | 6 | 1 | 7 |
| 2017 Junio | 13 | 7 | 20 |
| 2017 Mayo | 11 | 3 | 14 |
| 2017 Abril | 7 | 3 | 10 |
| 2017 Marzo | 13 | 17 | 30 |
| 2017 Febrero | 20 | 7 | 27 |
| 2017 Enero | 19 | 0 | 19 |
| 2016 Diciembre | 22 | 3 | 25 |
| 2016 Noviembre | 43 | 0 | 43 |
| 2016 Octubre | 48 | 3 | 51 |
| 2016 Septiembre | 9 | 2 | 11 |
| 2016 Agosto | 12 | 0 | 12 |
| 2016 Julio | 12 | 2 | 14 |
| 2016 Junio | 19 | 2 | 21 |
| 2016 Mayo | 16 | 4 | 20 |
| 2016 Abril | 16 | 0 | 16 |
| 2016 Marzo | 20 | 2 | 22 |
| 2016 Febrero | 16 | 1 | 17 |
| 2016 Enero | 15 | 0 | 15 |
| 2015 Diciembre | 17 | 0 | 17 |
| 2015 Noviembre | 18 | 0 | 18 |
| 2015 Octubre | 15 | 0 | 15 |
| 2015 Septiembre | 22 | 0 | 22 |
| 2015 Agosto | 13 | 0 | 13 |
| 2015 Julio | 11 | 0 | 11 |
| 2015 Junio | 6 | 0 | 6 |
| 2015 Mayo | 14 | 0 | 14 |
| 2015 Abril | 18 | 0 | 18 |
| 2015 Marzo | 11 | 0 | 11 |
| 2015 Febrero | 12 | 0 | 12 |
| 2015 Enero | 14 | 0 | 14 |
| 2014 Diciembre | 14 | 0 | 14 |
| 2014 Noviembre | 5 | 0 | 5 |
| 2014 Octubre | 3 | 0 | 3 |
| 2014 Septiembre | 4 | 0 | 4 |
| 2014 Agosto | 12 | 0 | 12 |
| 2014 Julio | 14 | 0 | 14 |
| 2014 Junio | 15 | 0 | 15 |
| 2014 Mayo | 11 | 0 | 11 |
| 2014 Abril | 7 | 0 | 7 |
| 2014 Marzo | 3 | 0 | 3 |
| 2014 Febrero | 5 | 0 | 5 |
| 2014 Enero | 3 | 0 | 3 |
| 2013 Diciembre | 5 | 0 | 5 |
| 2013 Noviembre | 7 | 0 | 7 |
| 2013 Octubre | 10 | 0 | 10 |
| 2013 Septiembre | 3 | 0 | 3 |
| 2013 Agosto | 4 | 0 | 4 |
| 2000 Marzo | 2212 | 0 | 2212 |
Mostrar todo
