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Citoqueratinas (UBC y CYFRA 21-1) y proteínas de la matriz nuclear (NMP22) como marcadores tumorales en la orina en el diagnóstico del cáncer vesical
Marta Sánchez-Carbayoa,*, Manuel Urrutiab, María Luisa Hernández-Cerceñoa, José Manuel González de Buitragoa, José Alejandro Navajoa
a Laboratorio de Marcadores Tumorales. Servicios de Bioquímica y Hospital Universitario de Salamanca
b Laboratorio de Marcadores Tumorales. Servicios de Urología. Hospital Universitario de Salamanca
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        "resumen" => "<span class="elsevierStyleSectionTitle">Fundamento</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Los marcadores tumorales en orina como UBC&#44; CYFRA 21-1 y NMP22 son una alternativano invasiva para el diagnostico del cancer vesical&#46;Se comparo la sensibilidad individual y combinada de los marcadores urinarios en la detecciondel cancer vesical con respecto a los metodos diagnosticos convencionales&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes Y M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se recogieron consecutivamente las orinas precistoscopia de 237 individuos&#58;44 pacientes con sospecha de cancer vesical primario y 193 pacientes en seguimientode cancer vesical&#46; UBC y NMP22 se cuantificaron por enzimoinmunoanalisis&#44; CYFRA 21-1 porelectroquimioluminiscencia&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Tomando como puntos de corte 9&#44;7 &#956;g&#47;l para UBC&#44; 5&#44;4 ng&#47;ml para CYFRA 21-1 y10&#44;0 U&#47;ml para NMP22 se encontraron unas sensibilidades del 70&#44; del 69 y del 67&#37;&#44; paraunas especificidades del 95&#44; del 94 y del 80&#37;&#44; respectivamente&#46; Todos los marcadores tumoralesurinarios presentaron sensibilidades superiores a la de la citologia urinaria &#40;7&#37;&#41;&#44; la presenciade microhematuria &#40;62&#37;&#41; y hematuria franca &#40;10&#37;&#41;&#44; cuyas especificidades fueron del99&#44; del 78 y del 99&#37;&#44; respectivamente&#46; La determinacion conjunta CYFRA 21-1 y NMP22 fuela combinacion que alcanzo la mayor sensibilidad &#40;79&#37;&#41;&#44; ligeramente inferior a la determinacionsimultanea de los tres marcadores &#40;80&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La sensibilidad de los marcadores tumorales UBC&#44; CYFRA 21-1 y NMP22 en orinapara el diagnostico de cancer vesical puede justificar su determinacion en sustitucion de la citologiaurinaria&#46; La similitud diagnostica de las citoqueratinas individualmente y en cada tipo depacientes en estudio desaconsejaria su determinacion simultanea&#46; La determinacion conjuntade NMP22 y un marcador de citoqueratinas &#40;CYFRA 21-1 o UBC&#41; se presenta como la masaconsejable&#46;</p> <span class="elsevierStyleSectionTitle">Background</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The development of urinary tumor markers such as UBC&#44; CYFRA 21-1 andNMP22 appeared to be non invasive alternative methods for the detection of bladder cancer&#46;We compared the individual and combined sensitivity of the urinary tumor markers in the detectionof bladder cancer&#44; contrasting them with the conventional diagnostic procedures&#46;</p> <span class="elsevierStyleSectionTitle">Patients and Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">237 voided urines from subjects under risk for bladder cancer were collectedimmediately before the endoscopic examinations&#58; 44 patients under suspicion of a primarybladder tumor and 193 patients under follow-up of a previous bladder cancer were included&#46;UBC and NMP22 were measured by enzyme-immunoabsorbent-assays and CYFRA 21-1by an electrochemiluminiscent-immunoassay&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Taking the cutoffs of 9&#46;7 &#236;g&#47;l for UBC&#44; 5&#46;4 ng&#47;ml for CYFRA 21-1 and 10&#46;0 U&#47;ml forNMP22 sensitivities were 70&#37;&#44; 69&#37; and 67&#37; for UBC&#44; CYFRA 21-1 and NMP22 at specificitiesof 95&#37;&#44; 94&#37; y 80&#37;&#44; respectively&#46; All tumor markers showed higher sensitivities than urinarycytology &#40;7&#37;&#41;&#44; microhematuria &#40;62&#37;&#41; and gross hematuria &#40;10&#37;&#41; at specificities of 99&#37;&#44;78&#37; and 99&#37;&#44; respectively&#46; The combinations of NMP22 plus CYFRA 21-1 reached the highestsensitivity &#40;79&#37;&#41;&#44; slightly lower than simultaneously measuring the three tumor markers &#40;80&#37;&#41;&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The sensitivities of the urinary markers UBC&#44; CYFRA 21-1 and NMP22 appearedto be high enough so as to substitute urinary cytology&#46; The diagnostic similarity between cytokeratinsindividually and in each type of patients might not recommend their simultaneous determination&#46;The combined measurement of NMP22 and one cytokeratin marker &#40;CYFRA 21-1or UBC&#41; appeared to be the most recommended&#46;</p>"
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        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:31 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Epidemiology and etiology of bladder cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;L&#46; Johansson"
                            1 => "S&#46;M&#46; Cohen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Surg Oncol"
                        "fecha" => "1990"
                        "volumen" => "13"
                        "paginaInicial" => "291"
                        "paginaFinal" => "298"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9259084"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biology and management of bladder cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "D&#46; Raghavan"
                            1 => "W&#46;U&#46; Shipley"
                            2 => "M&#46;B&#46; Garnick"
                            3 => "P&#46;J&#46; Russell"
                            4 => "J&#46;P&#46; Richie"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM199004193221607"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1990"
                        "volumen" => "322"
                        "paginaInicial" => "1129"
                        "paginaFinal" => "1138"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2181313"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "identificador" => "bib0015"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognostic markers in bladder cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46; Griffiths"
                            1 => "D&#46;E&#46; Neal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Curr Opin Urol"
                        "fecha" => "1996"
                        "volumen" => "6"
                        "paginaInicial" => "267"
                        "paginaFinal" => "271"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preventing recurrence and progression in superficial bladder cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D&#46;W&#46; Newling"
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                  ]
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                    0 => array:1 [
                      "Revista" => array:5 [
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                        "paginaFinal" => "279"
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bladder cancer&#58; natural history&#44; tumor markers and early detection strategies"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "W&#46;H&#46; Foresman"
                            1 => "E&#46;M&#46; Messing"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Surg Oncol"
                        "fecha" => "1997"
                        "volumen" => "13"
                        "paginaInicial" => "299"
                        "paginaFinal" => "306"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9259085"
                            "web" => "Medline"
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                ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New methods for detection of bladder cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "H&#46;B&#46; Grossman"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Urol Oncol"
                        "fecha" => "1998"
                        "volumen" => "16"
                        "paginaInicial" => "17"
                        "paginaFinal" => "22"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9508078"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Do we have a prostate specific antigen for bladder cancer&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "M&#46;S&#46; Soloway"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Urol"
                        "fecha" => "1999"
                        "volumen" => "161"
                        "paginaInicial" => "447"
                        "paginaFinal" => "448"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9915423"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Results of a multicenter trial using the BTA test to monitor for and diagnose recurrent bladder cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M&#46;F&#46; Sarosdy"
                            1 => "R&#46;W&#46; DeVere White"
                            2 => "M&#46;S&#46; Soloway"
                            3 => "J&#46; Shienfeld"
                            4 => "M&#46;A&#46; Hudson"
                            5 => "P&#46;F&#46; Schellhammer"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Urol"
                        "fecha" => "1995"
                        "volumen" => "154"
                        "paginaInicial" => "379"
                        "paginaFinal" => "384"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7609102"
                            "web" => "Medline"
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              "referencia" => array:1 [
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Initial evaluation of the bladder tumor antigen test in superficial bladder cancer"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;A&#46; D&#39;Hallewin"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "J Urol"
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                        "volumen" => "155"
                        "paginaInicial" => "475"
                        "paginaFinal" => "476"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8558639"
                            "web" => "Medline"
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                        "paginaFinal" => "367"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8683680"
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                      "titulo" => "Urinary nuclear matrix protein as a marker for transitional cell carcinoma of the urinary tract"
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                        "paginaInicial" => "1280"
                        "paginaFinal" => "1285"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8808854"
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                          ]
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                      "titulo" => "Evaluation of NMP22 in the detection of transitional cell carcinoma of the bladder"
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                            3 => "L&#46;W&#46; Willsey"
                            4 => "C&#46;P&#46; Dinney"
                            5 => "B&#46; Grossman"
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                        "tituloSerie" => "J Urol"
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                        "paginaInicial" => "394"
                        "paginaFinal" => "398"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9649246"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Liu BC-S&#46; Sensitivity and specificity of NMP22&#44; telomerase&#44; and BTA in the detection of human bladder cancer"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            2 => "E&#46; Kavaler"
                            3 => "M&#46;J&#46; Droller"
                          ]
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                        "paginaInicial" => "398"
                        "paginaFinal" => "402"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9730450"
                            "web" => "Medline"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "A multicenter trial evaluation of the fibrin&#47;fribrinogen degradation products test for detection and monitoring of bladder cancer"
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                          "etal" => true
                          "autores" => array:6 [
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                            2 => "D&#46;L&#46; Lamm"
                            3 => "A&#46; Morales"
                            4 => "N&#46;H&#46; Bander"
                            5 => "H&#46;B&#46; Grossman"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Urol"
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                        "paginaInicial" => "801"
                        "paginaFinal" => "805"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9258086"
                            "web" => "Medline"
                          ]
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                ]
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                    0 => array:2 [
                      "titulo" => "Rapid detection of bladder cancer&#58; a comparative study of point of care tests"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "B&#46; Johnston"
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                            2 => "L&#46; Emerson"
                            3 => "M&#46; Lundie"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Urol"
                        "fecha" => "1997"
                        "volumen" => "158"
                        "paginaInicial" => "2098"
                        "paginaFinal" => "2101"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9366321"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Keratins as biochemical markers of epithelial differentiation"
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                          "autores" => array:1 [
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                        "tituloSerie" => "TIG"
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                        "volumen" => "4"
                        "paginaInicial" => "277"
                        "paginaFinal" => "284"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2474874"
                            "web" => "Medline"
                          ]
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                      ]
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                    0 => array:2 [
                      "titulo" => "The catalog of human cytokeratins&#58; patterns of expression in normal epithelia&#44; tumors and cultured cells"
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                          "etal" => false
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                            2 => "D&#46;L&#46; Schiller"
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                            4 => "R&#46; Krepler"
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                        "tituloSerie" => "Cell"
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                        "paginaInicial" => "11"
                        "paginaFinal" => "17"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6186379"
                            "web" => "Medline"
                          ]
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            17 => array:3 [
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                    0 => array:2 [
                      "titulo" => "The biochemistry of CYFRA 21-1 and other cytokeratin-tests"
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                        "tituloSerie" => "Scand J Clin Lab Invest"
                        "fecha" => "1995"
                        "volumen" => "221"
                        "paginaInicial" => "60"
                        "paginaFinal" => "66"
                      ]
                    ]
                  ]
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                    0 => array:2 [
                      "titulo" => "Molecular characterization of a tissue-polypeptide-specific-antigen epitope and its relationship to human cytokeratin 18"
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                          "etal" => true
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                            4 => "G&#46; Steiner"
                            5 => "A&#46;-C&#46; Bergman"
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Biochem"
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                        "paginaInicial" => "309"
                        "paginaFinal" => "314"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8917424"
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                      "titulo" => "Clinical relevance of CYFRA 21-1&#44; TPA-IRMA and TPALIA-mat in urinary bladder cancer"
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                    ]
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                        "tituloSerie" => "Anticancer Res"
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                        "volumen" => "16"
                        "paginaInicial" => "3793"
                        "paginaFinal" => "3798"
                        "link" => array:1 [
                          0 => array:2 [
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                    0 => array:2 [
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                          0 => array:2 [
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                          0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "An initial evaluation of the diagnostic performance of the new urinary bladder antigen cancer test as a tumor marker for transitional cell carcinoma of the bladder"
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                        "paginaFinal" => "1115"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10081849"
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                    0 => array:2 [
                      "titulo" => "Identification of a nuclear protein matrix"
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                        "paginaFinal" => "1417"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4214419"
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                        "tituloSerie" => "J Cell Biochem"
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                        "link" => array:1 [
                          0 => array:2 [
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                        "paginaFinal" => "1694"
                        "link" => array:1 [
                          0 => array:2 [
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Información del artículo
ISSN: 00257753
Idioma original: Español
Datos actualizados diariamente
año/Mes Html Pdf Total
2024 Julio 1 0 1
2023 Septiembre 1 0 1
2023 Marzo 4 0 4
2021 Noviembre 1 0 1
2021 Octubre 2 0 2
2020 Octubre 2 0 2
2018 Noviembre 2 0 2
2017 Noviembre 1 0 1
2017 Octubre 21 6 27
2017 Septiembre 16 14 30
2017 Agosto 28 5 33
2017 Julio 15 25 40
2017 Junio 41 24 65
2017 Mayo 26 15 41
2017 Abril 26 11 37
2017 Marzo 18 18 36
2017 Febrero 21 8 29
2017 Enero 27 1 28
2016 Diciembre 31 2 33
2016 Noviembre 83 4 87
2016 Octubre 74 5 79
2016 Septiembre 52 9 61
2016 Agosto 13 2 15
2016 Julio 38 0 38
2016 Junio 50 1 51
2016 Mayo 77 4 81
2016 Abril 68 0 68
2016 Marzo 66 1 67
2016 Febrero 39 2 41
2016 Enero 38 0 38
2015 Diciembre 28 0 28
2015 Noviembre 62 0 62
2015 Octubre 56 0 56
2015 Septiembre 47 0 47
2015 Agosto 59 0 59
2015 Julio 30 0 30
2015 Junio 37 0 37
2015 Mayo 50 0 50
2015 Abril 45 0 45
2015 Marzo 27 0 27
2015 Febrero 17 0 17
2015 Enero 29 0 29
2014 Diciembre 20 0 20
2014 Noviembre 10 0 10
2014 Octubre 14 0 14
2014 Septiembre 12 0 12
2014 Agosto 7 0 7
2014 Julio 12 0 12
2014 Junio 13 0 13
2014 Mayo 7 0 7
2014 Abril 6 0 6
2014 Marzo 8 0 8
2014 Febrero 10 0 10
2014 Enero 7 0 7
2013 Diciembre 13 0 13
2013 Noviembre 15 0 15
2013 Octubre 28 0 28
2013 Septiembre 46 0 46
2013 Agosto 16 0 16
2000 Marzo 1014 0 1014
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