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"documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Med Clin. 2010;135 Supl 3:2-4" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1275 "formatos" => array:3 [ "EPUB" => 8 "HTML" => 1068 "PDF" => 199 ] ] "es" => array:10 [ "idiomaDefecto" => true "titulo" => "Metodología y objetivos del registro EUCORE" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "2" "paginaFinal" => "4" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Methodology and aims of the European Cubicin<span class="elsevierStyleSup">®</span> Outcome Registry and Experience (EUCORE) database" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jesús Rodríguez-Baño" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Jesús" "apellidos" => "Rodríguez-Baño" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0025775310700336?idApp=UINPBA00004N" "url" => "/00257753/00000135000000S3/v1_201304301955/S0025775310700336/v1_201304301955/es/main.assets" ] "es" => array:11 [ "idiomaDefecto" => true "titulo" => "Tratamiento actual de las infecciones por grampositivos: del modelo experimental a la experiencia clínica tras la autorización de nuevos fármacos" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "5" "paginaFinal" => "9" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "José Barberán" "autores" => array:1 [ 0 => array:3 [ "nombre" => "José" "apellidos" => "Barberán" "email" => array:1 [ 0 => "josebarberan@teleline.es" ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Enfermedades Infecciosas, Hospital Central de la Defensa Gómez Ulla, Madrid, España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec93702" "palabras" => array:5 [ 0 => "Daptomicina" 1 => "Modelos experimentales" 2 => "<span class="elsevierStyleItalic">Staphylococcus aureus</span> resistente a la meticilina" 3 => "Osteomielitis" 4 => "Infecciones de implantes" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec93701" "palabras" => array:5 [ 0 => "Daptomycin" 1 => "Experimental models" 2 => "Methicillin-resistant <span class="elsevierStyleItalic">Staphylococcus aureus</span>" 3 => "Osteomyelitis" 4 => "Implant-associated infections" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">La falta de ensayos clínicos limita el uso de los modernos antibióticos en la práctica clínica para indicaciones en las que parecen ser apropiados más allá de las indicaciones autorizadas. Cuando no hay alternativas válidas, el empleo de antimicrobianos fuera de indicación, los llamados <span class="elsevierStyleItalic">off-label</span>, se basa en datos de actividad microbiológica, farmacocinéticos y farmacodinámicos, y obtenidos de modelos experimentales, casos clínicos y de pequeñas series. Los modelos experimentales aportan información en indicaciones donde no hay ensayos clínicos y pueden solventar en parte la incapacidad de los nuevos fármacos para demostrar superioridad frente a los comparadores. Con daptomicina ya existen varios modelos experimentales en osteomielitis y en infecciones de implantes por <span class="elsevierStyleItalic">Staphylococcus aureus</span> resistentes a la meticilina, donde con dosis elevadas y asociada a rifampicina se han obtenido mejores resultados que con los comparadores.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">The use of modern antibiotics in clinical practice for indications that seem highly appropriate but are not approved is hampered by the lack of clinical trials. When there are no valid alternatives, the use of off-label antimicrobials is based on data obtained from microbiological activity, pharmacokinetic and pharmacodynamic profiles, experimental models, case reports and small series.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Experimental models provide information on indications not investigated in clinical trials and can partly solve the inability of new drugs to demonstrate superiority over comparators. Several experimental models in osteomyelitis and implant-associated infections by methicillin-resistant <span class="elsevierStyleItalic">Staphylococcus aureus</span> have demonstrated that daptomycin at high doses and in combination with rifampicin have produced superior results to comparators.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:28 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Design, analysis and presentation of factorial randomised controlled trials" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.A. Montgomery" 1 => "T.J. Peters" 2 => "P. 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Tratamiento actual de las infecciones por grampositivos: del modelo experimental a la experiencia clínica tras la autorización de nuevos fármacos
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Tratamiento actual de las infecciones por grampositivos: del modelo experimental a la experiencia clínica tras la autorización de nuevos fármacos
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