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Un sistema organizado de atención al ictus evita diferencias en la evolución de los pacientes en relación con el momento de su ingreso en una unidad de ictus
A stroke care management system prevents outcome differences related to time of stroke unit admission
R. Romero Sevilla, J.C. Portilla Cuenca, F. López Espuela, I. Redondo Peñas, I. Bragado Trigo, B. Yerga Lorenzana, M. Calle Escobar, M. Gómez Gutiérrez, I. Casado Naranjo
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icasadon@gmail.com

Autor para correspondencia.
Unidad de Ictus, Sección de Neurología, Hospital San Pedro de Alcántara, Cáceres, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">La organizaci&#243;n de equipos multidisciplinarios y estructuras enfocadas espec&#237;ficamente al cuidado de pacientes con un ictus agudo ha supuesto un importante cambio en el pron&#243;stico de estos pacientes<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">1</span></a>&#46; Diversos estudios han demostrado que disponer de un sistema organizado de atenci&#243;n al ictus y la utilizaci&#243;n de protocolos espec&#237;ficos de tratamiento se asocian con una disminuci&#243;n de la mortalidad&#44; dependencia y necesidad de institucionalizaci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0130"><span class="elsevierStyleSup">2&#8211;4</span></a>&#46; Sin embargo&#44; parece que los diferentes periodos laborales hospitalarios podr&#237;an influir en el pron&#243;stico de los pacientes&#58; se dispone de evidencia de que a los pacientes ingresados en fin de semana se les realizan menos pruebas diagn&#243;sticas&#44; reciben menos tratamientos de reperfusi&#243;n en el caso de un ictus isqu&#233;mico o procedimientos quir&#250;rgicos en el caso de ictus hemorr&#225;gicos<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">5&#8211;8</span></a>&#46; La informaci&#243;n procedente de la Canadian Stroke Network indica que los pacientes con un ictus ingresados durante los fines de semana presentan en comparaci&#243;n con los ingresados en d&#237;as laborables un mayor riesgo de muerte&#44; con independencia de la gravedad del ictus<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">9</span></a>&#46; Otros estudios muestran resultados m&#225;s sutiles&#58; se&#241;alan que los ingresos por ictus durante los fines de semana aumentan un 17&#37; la probabilidad de muerte<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">10</span></a>&#46; Existe pol&#233;mica entre los investigadores sobre si la utilizaci&#243;n de protocolos de tratamiento que homogenicen el cuidado proporcionado a estos pacientes por equipos o unidades de ictus &#40;UI&#41; soslaya las diferencias en su calidad&#44; con independencia del momento del ingreso y se evitan as&#237; las diferencias en la mortalidad y situaci&#243;n funcional<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">11&#44;12</span></a>&#46; Algunos autores se&#241;alan que durante los fines de semana se dispone de menos recursos humanos y diagn&#243;sticos&#44; situaci&#243;n que en nuestro sistema sanitario puede darse en otros periodos de tiempo tanto circadianos &#40;turnos de trabajo&#41; como anuales&#44; ya que algunos estudios demuestran que&#44; durante el turno de noche&#44; menores recursos se asocian con mayores tasas de mortalidad<a class="elsevierStyleCrossRefs" href="#bib0185"><span class="elsevierStyleSup">13&#44;14</span></a>&#46; Bajo esta premisa decidimos analizar si la evoluci&#243;n y la situaci&#243;n funcional de los pacientes variar&#237;a en funci&#243;n del turno laboral circadiano o durante el periodo de vacaciones de verano&#44; ya que&#44; en nuestro conocimiento&#44; no se ha estudiado el efecto del ingreso de los pacientes con ictus en este periodo en comparaci&#243;n con el resto del a&#241;o&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Nuestro objetivo fue analizar si la evoluci&#243;n precoz y la situaci&#243;n funcional a 3 meses de los pacientes admitidos en la UI difer&#237;a con relaci&#243;n a los distintos momentos en que se produce el ingreso hospitalario&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Sujetos y m&#233;todos</span><p id="par0015" class="elsevierStylePara elsevierViewall">Estudio retrospectivo de pacientes consecutivos ingresados entre junio de 2007 y diciembre de 2009 en una UI&#46; Nuestra UI atiende a una poblaci&#243;n de 411&#46;633 habitantes y es de referencia para una poblaci&#243;n de 1&#46;100&#46;000 residentes&#46; La estructura&#44; caracter&#237;sticas y los protocolos de actuaci&#243;n de nuestra UI ha sido previamente publicada<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Todos los pacientes ingresados se registran de forma prospectiva en una base de datos&#46; Los pacientes se clasificaron en 3 grupos seg&#250;n el tipo de ictus&#58; ataque isqu&#233;mico transitorio&#44; ictus isqu&#233;mico&#44; ictus hemorr&#225;gico<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">15</span></a>&#46; Para el an&#225;lisis de los datos&#44; diferenciamos periodos laborales que podr&#237;an interferir con la rutina del ritmo de trabajo en nuestra UI&#59; as&#237; agrupamos a los pacientes seg&#250;n el momento de su ingreso en la UI &#40;MIUI&#41; en&#58; a&#41; &#171;d&#237;a de la semana&#187;&#58; d&#237;a laborable &#40;desde las 08&#46;00<span class="elsevierStyleHsp" style=""></span>h del lunes hasta las 14&#46;59<span class="elsevierStyleHsp" style=""></span>h del viernes&#41; o fin de semana &#40;desde las 15&#46;00<span class="elsevierStyleHsp" style=""></span>h del viernes hasta las 07&#46;59<span class="elsevierStyleHsp" style=""></span>h del lunes&#41;&#59; b&#41; &#171;periodo anual&#187;&#58; vacaciones de verano &#40;desde el 1 julio hasta el 31 de agosto&#41; o meses acad&#233;micos &#40;desde el 1 de septiembre hasta el 30 de junio&#41; y c<span class="elsevierStyleItalic">&#41;</span> &#171;turno&#187;&#58; de ma&#241;ana &#40;desde las 08&#46;00 a las 14&#46;59<span class="elsevierStyleHsp" style=""></span>h&#41;&#44; de tarde &#40;de 15&#46;00 a 21&#46;59<span class="elsevierStyleHsp" style=""></span>h&#41; y de noche &#40;desde las 22&#46;00 a las 07&#46;59<span class="elsevierStyleHsp" style=""></span>h&#41;&#46; Otras variables que consideramos fueron la edad&#44; sexo&#44; escala de Rankin modificada<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">16</span></a> prem&#243;rbida &#8804; 2 &#40;puntuada sobre la base de la situaci&#243;n funcional previa al ictus determinada por la comorbilidad&#41;&#44; antecedentes de hipertensi&#243;n arterial&#44; diabetes mellitus&#44; dislipidemia&#44; ictus previo&#44; gravedad del ictus al ingreso determinada por la NIH StrokeScale &#40;NIHSS&#41;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">17</span></a>&#44; intervalo de tiempo entre el inicio de los s&#237;ntomas y evaluaci&#243;n por neur&#243;logo y estancia en la UI<span class="elsevierStyleItalic">&#46;</span> Para analizar la evoluci&#243;n precoz consideramos como variables principales la diferencia en la puntuaci&#243;n en la NIHSS al ingreso y al alta &#40;NIHSS diferencial&#41;&#44; las complicaciones neurol&#243;gicas &#40;transformaci&#243;n hemorr&#225;gica sintom&#225;tica o no&#44; ictus recurrentes&#44; hidrocefalia&#44; edema cerebral&#44; expansi&#243;n del hematoma&#44; delirio o crisis epil&#233;pticas&#41; y la mortalidad hospitalaria&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">En todos los pacientes se determin&#243; la situaci&#243;n funcional a los 3 meses a trav&#233;s de la escala de Rankin modificada aplicada durante la visita de seguimiento ambulatorio o por entrevista telef&#243;nica por un enfermero acreditado&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Tambi&#233;n determinamos el porcentaje de tratamiento de reperfusi&#243;n intravenosa en cada grupo&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">An&#225;lisis estad&#237;stico</span><p id="par0035" class="elsevierStylePara elsevierViewall">En el an&#225;lisis descriptivo las variables categ&#243;ricas se expresan en frecuencias absolutas &#40;porcentajes&#41;&#44; mientras que las variables cuantitativas se presentan como media y desviaci&#243;n est&#225;ndar &#40;DE&#41;&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">La asociaci&#243;n estad&#237;stica se realiz&#243; con el test chi cuadrado de Pearson para las variables cualitativas&#44; y los test t de Student o U Mann-Whitney para las variables cuantitativas&#44; seg&#250;n la distribuci&#243;n de la muestra&#46; La distribuci&#243;n de la muestra se determin&#243; con el test de Kolmogorov-Smirnov&#46; Se realiz&#243; un modelo de regresi&#243;n log&#237;stica para determinar los factores asociados con la mortalidad hospitalaria&#44; mortalidad a los 90 d&#237;as y el estado funcional a los 3 meses&#44; incluyendo en el an&#225;lisis multivariante aquellos factores asociados en el an&#225;lisis univariante&#44; con la variable dependiente con un valor de p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;20&#46; Las variables que mantuvieron el nivel de asociaci&#243;n &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;20&#41; permanecieron en el modelo&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Se consider&#243; la asociaci&#243;n estad&#237;stica para un valor de p&#160;&#60;&#160;0&#44;05&#46; Para el an&#225;lisis estad&#237;stico se us&#243; el paquete inform&#225;tico SPSS versi&#243;n 17&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="par0050" class="elsevierStylePara elsevierViewall">Durante el periodo del estudio ingresaron 1&#46;250 pacientes&#44; que constituyeron la muestra para el an&#225;lisis de las variables &#171;d&#237;a de la semana&#187; y &#171;periodo anual&#187;&#46; Los datos necesarios para la variable &#171;turno de trabajo&#187; solo estaban disponibles en 1&#46;098 pacientes&#46; En la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> se muestran las caracter&#237;sticas basales de los pacientes de acuerdo con cada definici&#243;n del MIUI&#46; El 60&#44;4&#37; del total de los pacientes eran hombres&#44; con una edad media de 70&#44;6<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;2<span class="elsevierStyleHsp" style=""></span>a&#241;os&#46; El 75&#37; de los pacientes presentaron un ictus isqu&#233;mico&#44; mientras que el 10&#44;6&#37; experiment&#243; un ictus hemorr&#225;gico&#44; y el 14&#44;4&#37; un ataque isqu&#233;mico transitorio&#46; Del total de la muestra&#44; el 36&#44;1&#37; de los pacientes presentaron ictus de origen aterotromb&#243;tico&#44; el 26&#44;7&#37; cardioemb&#243;licos&#44; un 25&#44;9&#37; de origen indeterminado&#44; un 8&#44;7&#37; correspondieron a ictus lacunar y el 2&#44;6&#37; fueron ictus de causa inhabitual&#44; sin encontrar diferencias significativas entre los distintos subtipos de ictus y el periodo laboral&#44; salvo para la variable d&#237;a de la semana&#44; donde el porcentaje de pacientes con un ictus lacunar que ingresaron en los d&#237;as laborables fue superior &#40;10&#44;3 vs&#46; 5&#44;3&#37;&#59; p&#160;&#61;&#160;0&#44;025&#41;&#46; Seg&#250;n el &#171;d&#237;a de la semana&#187;&#44; el 68&#44;8&#37; ingres&#243; en d&#237;a laborable y el 31&#44;2&#37; durante el fin de semana &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; Para la variable &#171;turno de trabajo&#187; el 41&#44;4&#37; de los pacientes ingresaron durante el turno de la ma&#241;ana&#44; el 35&#44;9&#37; durante el turno de tarde y 22&#44;4&#37; durante el turno de noche&#46; El 27&#44;1&#37; de los pacientes fueron hospitalizados durante las vacaciones de verano frente a un 72&#44;9&#37; durante los meses acad&#233;micos&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">No encontramos diferencias significativas en la edad&#59; el sexo&#59; escala de Rankin modificada prem&#243;rbida &#40;mRS<span class="elsevierStyleHsp" style=""></span>&#8804;<span class="elsevierStyleHsp" style=""></span>2&#41;&#59; antecedentes de hipertensi&#243;n arterial&#44; diabetes mellitus&#44; dislipidemia&#44; o ictus previo&#59; tampoco en la fibrilaci&#243;n auricular&#44; ni en el intervalo de tiempo entre el inicio de los s&#237;ntomas-evaluaci&#243;n por neur&#243;logo y en el tiempo de estancia en la UI &#40;<a class="elsevierStyleCrossRefs" href="#tbl0005">tablas 1 y 2</a>&#41;&#46; Los datos relacionados con la evoluci&#243;n precoz con relaci&#243;n al MIUI est&#225;n recogidos en la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#46; La puntuaci&#243;n media obtenida en la escala NIHS al ingreso fue 7&#44;38<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;94 en toda la muestra&#46; No se encontraron diferencias significativas en la puntuaci&#243;n NIHSS entre los pacientes ingresados en d&#237;a laborable &#40;7&#44;11<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;7&#41; y durante el fin de semana &#40;7&#44;99<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;3&#41;&#46; As&#237; mismo&#44; no hubo diferencias significativas en la NIHSS de los pacientes ingresados durante las vacaciones de verano &#40;7&#44;43<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;9&#41; ni los meses acad&#233;micos &#40;7&#44;27<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;9&#41;&#44; o durante el turno de ma&#241;ana &#40;7&#44;73<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;9&#41;&#44; por la tarde &#40;7&#44;28<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;9&#41;&#44; o en los turnos de noche &#40;7&#44;22<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;6&#59; <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Con relaci&#243;n al pron&#243;stico precoz&#44; encontramos que la NIHSS media diferencial fue de 2&#44;37<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;3&#59; no hubo diferencias estad&#237;sticamente significativas en funci&#243;n de los grupos MIUI&#46; No se encontraron diferencias significativas en la mortalidad hospitalaria entre los pacientes que ingresaron en d&#237;a laborable y en los ingresos durante los fines de semana&#44; ni en los pacientes ingresados durante las vacaciones de verano frente a los meses acad&#233;micos&#44; o en los admitidos en los diferentes turnos de trabajo&#46; En el modelo de regresi&#243;n univariante y multivariante ajustado por edad&#44; sexo&#44; tipo de ictus&#44; MRS&#160;&#8804;&#160;2 prem&#243;rbido y la escala NIHS&#44; no se encontraron diferencias significativas entre los grupos de estudio con relaci&#243;n a la mortalidad hospitalaria &#40;<a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#41;&#46; Con relaci&#243;n a dicha mortalidad hospitalaria&#44; en el 71&#37; de los casos estuvo relacionada con la evoluci&#243;n del ictus &#40;transformaci&#243;n hemorr&#225;gica&#44; edema cerebral&#44; recurrencia&#41;&#44; el 16&#44;2&#37; se asoci&#243; a complicaciones cardiacas&#44; el 6&#44;4&#37; a complicaciones de origen respiratorio y en un 6&#44;4&#37; fueron de origen infeccioso&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">Encontramos una ligera tendencia a realizar mayor n&#250;mero de tratamientos de reperfusi&#243;n intravenosa en los pacientes ingresados en d&#237;a laborable &#40;11&#44;2&#37;&#41;&#44; durante el turno de la ma&#241;ana &#40;13&#44;6&#37;&#41; y durante los meses acad&#233;micos &#40;11&#44;6&#37;&#41;&#59; sin embargo&#44; estas diferencias no alcanzaron la significaci&#243;n estad&#237;stica&#46; El 27&#44;0&#37; de los pacientes ingresados durante el fin de semana presentaron alg&#250;n tipo de complicaci&#243;n neurol&#243;gica&#44; frente a un 20&#44;0&#37; en los pacientes ingresados en d&#237;a laborable &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;014&#41;&#46; No encontramos diferencias significativas en los otros grupos de estudio &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia><p id="par0065" class="elsevierStylePara elsevierViewall">Con relaci&#243;n a la situaci&#243;n funcional a los 3 meses&#44; encontramos que el 67&#44;0&#37; de los ingresos en d&#237;a laborable y el 60&#44;7&#37; de los ingresos durante el fin de semana eran independientes &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;096&#41;&#46; As&#237; mismo&#44; el 65&#44;5&#37; de los pacientes ingresados durante los meses acad&#233;micos vs&#46; el 63&#44;5&#37; vacaciones de verano &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;803&#41; eran independientes&#46; No hubo diferencias significativas en el porcentaje de pacientes funcionalmente independientes a los 3 meses entre los diferentes turnos de trabajo &#40;<a class="elsevierStyleCrossRef" href="#tbl0025">tabla 5</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0025"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">En consonancia con lo anterior&#44; y tras realizar los modelos de regresi&#243;n log&#237;stica&#44; no encontramos diferencias significativas en la independencia funcional de los diferentes grupos de estudio&#46; No se identificaron diferencias significativas en la mortalidad a los 3 meses vinculada al d&#237;a de la semana ni al periodo anual&#46; Sin embargo&#44; s&#237; encontramos una diferencia significativa para la variable &#171;turno de trabajo&#187;&#44; donde la mortalidad a los 3 meses fue del 12&#44;5&#37; para los pacientes que ingresaron durante el turno de la ma&#241;ana&#44; el 11&#44;1&#37; para el turno de la tarde&#44; y el 5&#44;7&#37; para el turno de noche &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#41;&#44; significaci&#243;n estad&#237;stica que se sostuvo tras realizar el modelo de regresi&#243;n log&#237;stica ajustado &#40;<a class="elsevierStyleCrossRef" href="#fig0005">fig&#46; 1</a>&#44; <a class="elsevierStyleCrossRef" href="#tbl0030">tabla 6</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0030"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discusi&#243;n</span><p id="par0075" class="elsevierStylePara elsevierViewall">Los resultados de nuestro estudio indican que el ingreso de los pacientes en una UI en diferentes periodos laborales &#40;meses de vacaciones o acad&#233;micos&#44; d&#237;as laborables o fines de semanas y turnos de trabajo&#41; no tiene efecto sobre la evoluci&#243;n precoz o la situaci&#243;n funcional a los 3 meses&#46; Adem&#225;s&#44; los diferentes periodos laborales no influyeron ni en el porcentaje de pacientes que recibieron tratamiento trombol&#237;tico ni en la mortalidad hospitalaria entre los diferentes grupos&#46; Si bien el porcentaje de complicaciones neurol&#243;gicas&#44; en un rango de leve a grave&#44; fue ligeramente superior en los ingresados durante el fin de semana en comparaci&#243;n con los ingresos en d&#237;as laborables&#44; este hecho no parece influir sobre la mortalidad precoz en los diferentes grupos considerados&#46; Tampoco pueden atribuirse los resultados obtenidos a discrepancias en las caracter&#237;sticas basales de la poblaci&#243;n estudiada&#44; teniendo en cuenta la distribuci&#243;n homog&#233;nea de las variables demogr&#225;ficas&#44; tipos o gravedad del ictus al ingreso&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Otros estudios realizados en UI se&#241;alan que un sistema organizado de atenci&#243;n al ictus puede obviar potenciales dificultades ocasionadas en funci&#243;n del ingreso en diferentes periodos laborales&#44; previniendo peores resultados<a class="elsevierStyleCrossRefs" href="#bib0175"><span class="elsevierStyleSup">11&#44;12&#44;18&#8211;20</span></a>&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">En relaci&#243;n con el pron&#243;stico precoz&#44; no encontramos diferencias significativas en la mortalidad hospitalaria seg&#250;n los diferentes MIUI&#46; Nuestros resultados est&#225;n en concordancia con los obtenidos por Albright et al&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">11</span></a> y Martinez et al&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a>&#46; Adem&#225;s&#44; de acuerdo con otros estudios realizados en centros de ictus que evaluaron la mortalidad y la situaci&#243;n funcional a los 3 meses&#44; nuestros resultados indican que estas variables pron&#243;sticas no resultan afectadas si el ingreso se produjo en d&#237;as laborables o en fines de semana&#46; El estudio de McKinney et al&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">21</span></a> encontr&#243; que&#44; entre los ingresados en fin de semana&#44; la mortalidad fue un 5&#37; superior en centros carentes de sistemas organizativos especializados en la atenci&#243;n al ictus&#46; Es importante subrayar que nosotros no encontramos diferencias en la mortalidad a los 3 meses en funci&#243;n del periodo anual de ingreso&#46; Sin embargo&#44; la mortalidad de los pacientes ingresados durante el turno de noche fue inferior a la mortalidad de los pacientes ingresados en otros turnos&#46; Pensamos que el azar u otros factores que no hemos considerado pueden haber contribuido a este resultado&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">Si bien algunos estudios se&#241;alan que durante los fines de semana la reducci&#243;n del personal y una menor disponibilidad de recursos pueden dar lugar a una menor utilizaci&#243;n de procedimientos diagn&#243;sticos o terap&#233;uticos&#44; otros estudios que analizaron el &#171;efecto fin de semana&#187; observaron que se realizaron un mayor n&#250;mero de tromb&#243;lisis durante el turno de noche o los fines de semana<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">22</span></a>&#46; As&#237;&#44; seg&#250;n el estudio de Hoh et al&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">23</span></a>&#44; los pacientes que ingresaron en los fines de semana tuvieron una probabilidad un 11&#37; superior de recibir tratamiento trombol&#237;tico&#46; Nosotros hemos observado una tendencia no significativa a realizar m&#225;s veces este procedimiento durante el turno de ma&#241;ana&#44; los d&#237;as laborables y durante los meses acad&#233;micos&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Debido a las diferencias metodol&#243;gicas de los estudios que han analizado el &#171;efecto fin de semana&#187;&#44; resulta dif&#237;cil comparar los resultados obtenidos y lo es m&#225;s a&#250;n extraer conclusiones&#46; La principal limitaci&#243;n de los estudios es el peque&#241;o tama&#241;o de las muestras de los estudios realizados en UI<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">12</span></a>&#44; las diferencias en los recursos disponibles y la continuidad en la atenci&#243;n neurol&#243;gica seg&#250;n el tipo de hospital y el dise&#241;o retrospectivo de aquellos estudios con muestras de mayor tama&#241;o<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">24</span></a>&#46; Nuestro estudio presenta sus propias limitaciones&#44; especialmente el an&#225;lisis retrospectivo de datos obtenidos de forma prospectiva&#44; adem&#225;s de ser un estudio realizado en un &#250;nico hospital&#46; Por otra parte&#44; es posible que factores no controlados tras el alta hospitalaria pudieran haber influido en los resultados de la mortalidad a los 3 meses&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conclusiones</span><p id="par0100" class="elsevierStylePara elsevierViewall">Los resultados de este estudio muestran que el momento en el que se produce el ingreso en nuestra UI no afecta al pron&#243;stico precoz ni a la independencia funcional a los 3 meses&#46; Esto probablemente se deba a la estricta adherencia a los protocolos de actuaci&#243;n por parte de los facultativos&#44; del personal de enfermer&#237;a y de otros profesionales&#44; lo que garantiza la sistematizaci&#243;n de los cuidados con independencia del momento del ingreso&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicto de intereses</span><p id="par0105" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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          "titulo" => "Sujetos y m&#233;todos"
          "secciones" => array:1 [
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              "identificador" => "sec0015"
              "titulo" => "An&#225;lisis estad&#237;stico"
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          "titulo" => "Resultados"
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          "titulo" => "Discusi&#243;n"
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          "titulo" => "Conclusiones"
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          "titulo" => "Conflicto de intereses"
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          "identificador" => "xack211369"
          "titulo" => "Agradecimientos"
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          "titulo" => "Bibliograf&#237;a"
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    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-11-03"
    "fechaAceptado" => "2015-07-19"
    "PalabrasClave" => array:2 [
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        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec640239"
          "palabras" => array:6 [
            0 => "Pron&#243;stico"
            1 => "Fin de semana"
            2 => "Unidad de ictus"
            3 => "Tromb&#243;lisis"
            4 => "Ingreso"
            5 => "Ictus agudo"
          ]
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      ]
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        0 => array:4 [
          "clase" => "keyword"
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          "palabras" => array:6 [
            0 => "Outcome"
            1 => "Weekend"
            2 => "Stroke unit"
            3 => "Thrombolysis"
            4 => "Admission"
            5 => "Acute stroke"
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Introducci&#243;n</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Existe evidencia de que el ingreso de pacientes con ictus en diferentes periodos laborales influye en su evoluci&#243;n&#46; Analizamos la evoluci&#243;n de los pacientes con relaci&#243;n al momento del ingreso en una unidad de ictus&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio retrospectivo&#46; Se agrup&#243; a los pacientes considerando los siguientes periodos&#58; a&#41; d&#237;a de la semana&#44; b&#41; periodo del a&#241;o y c&#41; turno de trabajo&#46; Analizamos caracter&#237;sticas demogr&#225;ficas&#44; tipo y gravedad del ictus y porcentaje de tromb&#243;lisis&#46; Determinamos la evoluci&#243;n precoz considerando&#58; la National Institute of Heath Stroke Scale &#40;NIHSS&#41;&#44; complicaciones neurol&#243;gicas &#40;CN&#41; y mortalidad hospitalaria&#44; y situaci&#243;n funcional &#40;SF&#41; a 3 meses mediante la escala modificada de Rankin&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluy&#243; a 1&#46;250 pacientes&#46; Las CN fueron m&#225;s frecuentes durante el fin de semana que en los d&#237;as laborales&#44; sin influir en la mortalidad hospitalaria&#46; Respecto a la SF a 3 meses&#44; el 67&#44;0&#37; de pacientes ingresados en d&#237;as laborales vs&#46; 60&#44;7&#37; durante el fin de semana &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;096&#41;&#44; el 65&#44;5&#37; de los pacientes ingresados durante los meses acad&#233;micos vs&#46; 63&#44;5&#37; durante las vacaciones de verano &#40;p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;803&#41; eran independientes&#46; No identificamos diferencias significativas en la mortalidad a 3 meses seg&#250;n el d&#237;a o periodo del a&#241;o&#59; sin embargo&#44; para la variable turno de trabajo&#44; el 13&#44;2&#37; de los pacientes ingresados durante la ma&#241;ana&#44; el 11&#44;5&#37; por la tarde y el 6&#44;0&#37; durante el turno de noche fallecieron &#40;p&#160;&#61;&#160;0&#44;017&#41;&#46; Observamos una tendencia a realizar m&#225;s fibrin&#243;lisis en d&#237;as laborables&#44; turno de la ma&#241;ana y meses acad&#233;micos&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El momento del ingreso en la unidad de ictus no influy&#243; en la evoluci&#243;n precoz ni en la situaci&#243;n de independencia a 3 meses&#46;</p></span>"
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          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Introducci&#243;n"
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          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "M&#233;todos"
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          2 => array:2 [
            "identificador" => "abst0015"
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      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Introduction</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Evidence supports that admitting patients with stroke during different hospital work periods is related to distinct outcomes&#46; We aimed to analyse outcomes in patients according to the period and time of admission to the stroke unit&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Retrospective study&#46; For purposes of data analysis&#44; patients were grouped according to the following time periods&#58; <span class="elsevierStyleItalic">a&#41;</span> day of the week&#44; <span class="elsevierStyleItalic">b&#41;</span> period of the year&#44; <span class="elsevierStyleItalic">c&#41;</span> shift&#46; We analysed demographic characteristics&#44; stroke type and severity&#44; and the percentage undergoing thrombolysis in each group&#46; The measures used to evaluate early outcomes were the National Institutes of Health Stroke Scale &#40;NIHSS&#41;&#44; neurological complications &#40;NC&#41;&#44; and in-hospital mortality&#46; Functional outcome at 3 months was determined using the modified Rankin scale&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The stroke unit admitted 1250 patients&#46; We found NC to be slightly more frequent for weekend admissions than for weekday admissions&#44; but this trend does not seem to have influenced in-hospital mortality&#46; Regarding functional outcome at 3 months&#44; 67&#46;0&#37; of weekday vs&#46; 60&#46;7&#37; of weekend admissions were independent &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;096&#41;&#44; as were 65&#46;5&#37; of patients admitted during the academic months vs&#46; 63&#46;5&#37; of those admitted during summer holidays &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;803&#41;&#46; We identified no significant differences in 3-month mortality linked to the day or period of admission&#59; however&#44; for the variable &#8216;shift&#8217;&#44; 13&#46;2&#37; of the patients died during the morning shift&#44; 11&#46;5&#37; during the afternoon shift&#44; and 6&#46;0&#37; during the night shift &#40;<span class="elsevierStyleItalic">P</span>&#61;&#46;017&#41;&#46; We identified a trend toward higher rates of thrombolysis administration on weekdays&#44; during the morning shift&#44; and during the academic months&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Time of admission to the stroke unit did not affect early outcomes or functional independence at 3 months&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0040">Presentado parcialmente como comunicaci&#243;n oral en la LXV Reuni&#243;n Anual de la Sociedad Espa&#241;ola de Neurolog&#237;a&#44; Barcelona&#44; noviembre de 2013&#46;</p>"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Relaci&#243;n entre el ingreso en la UI y la situaci&#243;n funcional a los 3 meses&#46;</p>"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">DE&#58; desviaci&#243;n est&#225;ndar&#59; mRS&#58; escala modificada de Rankin&#59; NIHSS&#58; National Institute of Health Stroke Scale&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">p<span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#62;</span><span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p>"
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">70&#44;68<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>12&#44;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">522 &#40;60&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">233 &#40;59&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">277 &#40;61&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">376 &#40;96&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">437 &#40;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">381 &#40;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">238 &#40;96&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">877 &#40;96&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">328 &#40;96&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NIHSS al ingreso&#44; media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;38<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;11<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;99<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>7&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;73<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;28<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;22<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#44;43<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">7&#46;27<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>6&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Hipertensi&#243;n&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">822 &#40;65&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">577 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">245 &#40;63&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">310 &#40;68&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">260 &#40;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">163 &#40;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">605 &#40;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">217 &#40;64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Diabetes mellitus&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">339 &#40;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">241 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">98 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">127 &#40;28&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">106 &#40;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65 &#40;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">241 &#40;26&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">98 &#40;29&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Dislipidemia&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">476 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">324 &#40;37&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">152 &#40;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">181 &#40;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">155 &#40;39&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">89 &#40;36&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">349 &#40;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">127 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Cardiopat&#237;a isqu&#233;mica&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">180 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">125 &#40;14&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">32 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">141 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Ictus previo&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">232 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">153 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">79 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">84 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">83 &#40;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">40 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">173 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Fibrilaci&#243;n auricular&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">188 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">115 &#40;13&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">73 &#40;18&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">35 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">140 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">48 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Estancia UI &#40;d&#237;as&#41;&#44; media<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>DE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;9 &#177;1&#44;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#46;8<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tabaquismo&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">212 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">141 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">71 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">80 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">37 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">151&#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Consumo de alcohol&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">221 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">145 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">76 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">88 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74 &#40;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">39 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">155 &#40;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">66 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Tiempo entre inicio de s&#237;ntomas y valoraci&#243;n neur&#243;logo &#40;&#8804; 6<span class="elsevierStyleHsp" style=""></span>h&#41; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">670 &#40;54&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">424 &#40;56&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">201 &#40;58&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">261 &#40;57&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">227 &#40;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">137 &#40;55&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">473 &#40;58&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">152 &#40;52&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black"></th><th class="td" title="table-head  " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Tipo de ictus</th></tr><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">AIT&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Hemorr&#225;gico&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="char" valign="top"><span class="elsevierStyleItalic">Ingreso&#44; d&#237;a de la semana&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Laborable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">130 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">636 &#40;74&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">94 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">860 &#40;68&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="3" align="char" valign="top">0&#44;455</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fin de semana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">50 &#40;12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">301 &#40;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">390 &#40;31&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">180 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">937 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">133 &#40;10&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1250 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">Turno&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ma&#241;ana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">57 &#40;12&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">349 &#40;76&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;10&#44;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">455 &#40;41&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="4" align="char" valign="top">0&#44;631</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Tarde&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">65 &#40;16&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">291 &#40;73&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">39 &#40;9&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">395 &#40;35&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Noche&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">37 &#40;15&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">179 &#40;72&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">31 &#40;12&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">247 &#40;22&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">159 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">819 &#40;74&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">120 &#40;10&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;098 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="6" align="left" valign="top"><span class="elsevierStyleItalic">Periodo del a&#241;o&#44; n &#40;&#37;&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Meses acad&#233;micos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">131 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">679 &#40;74&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">101 &#40;11&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">911 &#40;72&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="3" align="char" valign="top">0&#44;700</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Vacaciones de verano&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">49 &#40;14&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">258 &#40;76&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">32 &#40;9&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">339 &#40;27&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">180 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">937 &#40;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">133 &#40;10&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#46;250 &#40;100&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Mortalidad hospitalaria</th></tr><tr title="table-row"><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">An&#225;lisis univariante</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">An&#225;lisis multivariante<a class="elsevierStyleCrossRef" href="#tblfn0020"><span class="elsevierStyleSup">&#42;</span></a></th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">MIUI</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">OR&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;761&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;418-1&#44;386&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Turno</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ma&#241;ana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Tarde&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;973&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;542-1&#44;746&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;092&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;585-2&#44;041&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Noche&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;552&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;246-1&#44;239&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;535&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;228-1&#44;258&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;834&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;479-1&#44;453&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;303&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;721-2&#44;352&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
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                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black"></th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Ingreso&#58; d&#237;a de la semana</th><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p</th><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Turno</th><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Periodo anual</th><th class="td" title="table-head  " rowspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p</th></tr><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Laborable&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ma&#241;ana&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">NIHSS diferencial&#44; <span class="elsevierStyleItalic">media</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#177;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">DE</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;5<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;07<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;181&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;2<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;9<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;0<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;4<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;1<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>5&#44;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Mortalidad hospitalaria <span class="elsevierStyleItalic">n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">44 &#40;5&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18 &#40;4&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;706&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">26 &#40;5&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">22 &#40;5&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8 &#40;3&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;522&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;4&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">19 &#40;5&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;430&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Complicaciones neurol&#243;gicas&#44; <span class="elsevierStyleItalic">n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">117 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74 &#40;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;014&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">41 &#40;24&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;750&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">141 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">50 &#40;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;902&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">Porcentaje de tromb&#243;lisis iv &#40;rtPA&#41;&#44; <span class="elsevierStyleItalic">n &#40;&#37;&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">96 &#40;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">43 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;745&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62 &#40;18&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">41 &#40;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">23 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;220&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">106 &#40;16&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">33 &#40;13&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;278&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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          "es" => "<p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">Pron&#243;stico precoz seg&#250;n el momento del ingreso en la Unidad de Ictus</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Momento de ingreso en la UI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Independencia funcional &#40;mRS&#160;&#8804;&#160;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">p&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">D&#237;a de la semana &#40;n&#61; 1&#46;250&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Laborable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">552 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="char" valign="top">0&#44;096</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Fin de semana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">227 &#40;60&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Turno &#40;n</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">1&#46;098&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ma&#241;ana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">274 &#40;63&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="3" align="char" valign="top">0&#44;231</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Tarde&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Noche&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">148 &#40;63&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="3" align="left" valign="top"><span class="elsevierStyleItalic">Periodo del a&#241;o &#40;n</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">&#61;</span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleItalic">1&#46;250&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Meses acad&#233;micos&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " rowspan="2" align="char" valign="top">0&#44;803</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Vacaciones de verano&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">206 &#40;63&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">An&#225;lisis univariante</th></tr><tr title="table-row"><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Independencia a 3 meses</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Mortalidad a 3 meses</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">MIUI</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IC 95&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">OR&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">IC 95&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;771-1&#44;654&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleItalic">Turno</span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Ma&#241;ana&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Ref&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Tarde&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;261&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;943-1&#44;687&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;854&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;561-1&#44;299&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Noche&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;999&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;718-1&#44;389&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">0&#44;420&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;229-0&#44;771&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="table-entry  " colspan="5" align="left" valign="top"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">Vacaciones de verano</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;090&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;836-1&#44;423&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">1&#44;033&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="char" valign="top">&#40;0&#44;691-1&#44;544&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            1 => array:2 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " colspan="5" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">An&#225;lisis multivariante<a class="elsevierStyleCrossRef" href="#tblfn0025"><span class="elsevierStyleSup">&#42;</span></a></th></tr><tr title="table-row"><th class="td" title="table-head  " colspan="3" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Independencia a 3 meses</th><th class="td" title="table-head  " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Mortalidad a 3 meses</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top"><span class="elsevierStyleItalic">MIUI</span>&nbsp;\t\t\t\t\t\t\n
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ISSN: 02134853
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