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Evaluación de la incidencia y tendencia de la enfermedad cerebrovascular en la región sanitaria de Lleida (España) en el periodo 2010-2014
Assessment of incidence and trends in cerebrovascular disease in the healthcare district of Lleida (Spain) in the period 2010-2014
A.B. Venaa,b, X. Cabréc, R. Piñold, J. Molinab,e, F. Purroyb,e,
Autor para correspondencia
fpurroygarcia@gmail.com

Autor para correspondencia.
a Servicio de Geriatría, Hospital Universitario de Santa María, Lleida, España
b Grupo de Neurociencias Clínicas, Universidad de Lleida, IRBLleida, Lleida, España
c Área de calidad, Hospital Universitario Arnau de Vilanova, Lleida, España
d Gerencia territorial área de Lleida, Lleida, España
e Unidad de Ictus, Hospital Universitario Arnau de Vilanova, Lleida, España
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            "entidad" => "Grupo de Neurociencias Cl&#237;nicas&#44; Universidad de Lleida&#44; IRBLleida&#44; Lleida&#44; Espa&#241;a"
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        "titulo" => "Assessment of incidence and trends in cerebrovascular disease in the healthcare district of Lleida &#40;Spain&#41; in the period 2010-2014"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Comparaci&#243;n de la incidencia cruda por grupos etarios y sexo para ictus &#40;A&#41;&#44; ictus isqu&#233;mico &#40;B&#41; e ictus hemorr&#225;gico &#40;C&#41;&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introduccion</span><p id="par0005" class="elsevierStylePara elsevierViewall">La enfermedad cerebrovascular &#40;ECV&#41; tiene un gran impacto social<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; A nivel mundial&#44; se calcula que en un a&#241;o 15 millones de personas sufren un ictus&#44; de las cuales<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">4&#44;5</span></a> 6&#44;7 millones acaban muriendo<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; Adem&#225;s&#44; de los que sobreviven&#44; m&#225;s de la mitad presentan alg&#250;n tipo de discapacidad<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; En el momento actual la incidencia promedio mundial seg&#250;n la Organizaci&#243;n Mundial de Salud &#40;OMS&#41; es de 200 casos nuevos por cada 100&#46;000 habitantes y a&#241;o<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">3&#8211;7</span></a>&#46; Sin embargo&#44; la revisi&#243;n sistem&#225;tica de diferentes trabajos epidemiol&#243;gicos nos permite conocer la existencia de diferencias significativas en las tasas de incidencia en funci&#243;n del &#225;rea geogr&#225;fica y los niveles de ingresos<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">3&#8211;8</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">En Espa&#241;a&#44; las enfermedades cerebrovasculares representan la tercera causa de mortalidad&#46; Hasta la fecha existen pocos estudios que analicen la incidencia de ictus en diversas regiones espa&#241;olas que adem&#225;s tienen metodolog&#237;a y datos heterog&#233;neos<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">9&#44;10</span></a>&#46; As&#237;&#44; la incidencia global estimada oscila entre 120 y 350 casos por 100&#46;000 habitantes&#47;a&#241;o<a class="elsevierStyleCrossRefs" href="#bib0230"><span class="elsevierStyleSup">11&#8211;18</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Nuestro estudio tiene como objetivo principal analizar la incidencia del ictus de forma global&#44; as&#237; como de sus diferentes subtipos&#44; hemorr&#225;gico e isqu&#233;mico&#44; en la poblaci&#243;n del &#225;rea sanitaria de Lleida y estimar su tendencia durante 5 a&#241;os&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material y m&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Desarrollamos un estudio prospectivo y observacional que incluy&#243; a toda la poblaci&#243;n del &#193;rea sanitaria de Lleida que sufri&#243; un ictus en el periodo comprendido desde el 1 enero de 2010 al 31 diciembre de 2014&#46; Para su dise&#241;o se tuvieron en cuenta los criterios de estudio de incidencia &#171;ideal&#187; propuestos por Malgrem et al&#46;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">19</span></a>&#44; Sudlow y Warlow<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">20</span></a>&#44; as&#237; como el estudio IBERICTUS<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">10</span></a>&#46; En todos los casos se requiri&#243; la realizaci&#243;n de una prueba de neuroimagen &#40;tomograf&#237;a axial computarizada o resonancia magn&#233;tica&#41; para inclusi&#243;n de los pacientes&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Como fuentes primarias de datos se utilizaron los listados del Conjunto M&#237;nimo B&#225;sico de Datos &#40;CMBD&#41; de urgencias y de las altas hospitalarias &#8212;codificadas seg&#250;n la novena revisi&#243;n de la Clasificaci&#243;n Internacional de Enfermedades &#40;CIE-9&#41;&#8212; del hospital de referencia del &#225;rea de estudio&#44; el Hospital Universitario Arnau de Vilanova&#44; Lleida&#44; Espa&#241;a&#44; en el per&#237;odo indicado&#46; Se defini&#243; el ictus&#44; seg&#250;n criterios diagn&#243;sticos del proyecto MONICA de la OMS&#44; como el desarrollo r&#225;pido de signos cl&#237;nicos de trastorno de la funci&#243;n cerebral focal o global que dura m&#225;s de 24<span class="elsevierStyleHsp" style=""></span>h a excepci&#243;n de interrupci&#243;n por cirug&#237;a o muerte sin otra aparente causa m&#225;s que su origen cerebrovascular una disfunci&#243;n neurol&#243;gica focal o global de inicio s&#250;bito y de duraci&#243;n mayor a 24<span class="elsevierStyleHsp" style=""></span>h&#46; Para identificar un ictus isqu&#233;mico se tuvieron en cuenta los c&#243;digos 43310&#44; 43311&#44; 43321&#44; 43330&#44; 43331&#44; 43380&#44; 43381&#44; 43411&#44; 43490&#44; 43491&#44; 436&#44; 4370&#44; 4371&#44; 4372&#44; 4373&#44; 4377&#44; 4378 y 4379&#46; Para identificar a un ictus hemorr&#225;gico los c&#243;digos 430&#44; 431 y 4329&#46; Todos los posibles casos fueron posteriormente revisados por un m&#233;dico investigador que verific&#243; y valid&#243; el diagn&#243;stico tras examinar el informe de alta y la historia cl&#237;nica&#46; Se excluyeron expl&#237;citamente todos aquellos pacientes con diagn&#243;stico de isquemia transitoria &#40;c&#243;digos CIE-9&#58; Accidente cerebrovascular isqu&#233;mico transitorio&#58; 4350&#44; 4353&#44; 4358 y 4359&#41; con diagn&#243;stico de otras hemorragias cerebrales&#44; otra enfermedad cerebral o cerebrovascular mal definida y los efectos tard&#237;os de las enfermedades cerebrovasculares &#40;c&#243;digos CIE-9&#58; 432&#44; 433&#46;x0&#44; 434&#46;x0&#44; 437 y 438&#41;<span class="elsevierStyleItalic">&#46;</span> La poblaci&#243;n de referencia la compusieron el total de residentes en el &#193;rea sanitaria de Lleida&#46; Se consider&#243; residente todo aquel sujeto empadronado en un municipio de la provincia de Lleida que vive un m&#237;nimo de 6 meses al a&#241;o en dicha &#225;rea seg&#250;n describe el Instituto Nacional de Estad&#237;stica&#46; El estudio fue aprobado por el comit&#233; &#233;tico de nuestro centro&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">An&#225;lisis estad&#237;stico</span><p id="par0030" class="elsevierStylePara elsevierViewall">Se estratific&#243; la muestra tanto por grupos de edad &#40;0-34&#44; 35-39&#44; 40-44&#44; 45-49&#44; 50-54&#44; 55-59&#44; 60-64&#44; 65-69&#44; 70-74&#44; 75-79&#44; 80-84 y &#62;<span class="elsevierStyleHsp" style=""></span>85&#41;&#44; como por sexo y subtipo de ictus &#40;isqu&#233;mico o hemorr&#225;gico&#41;&#46; Se determin&#243; la tasa bruta y la tasa estandarizada por edad utilizando la poblaci&#243;n est&#225;ndar de la OMS de 2001 por 100&#46;000 habitantes<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">21</span></a>&#46; Adem&#225;s&#44; se determin&#243; la tendencia de las tasas calculadas en el periodo de tiempo analizado mediante el c&#225;lculo del cambio porcentual anual &#40;CPA&#41;&#46; que permitir&#225; evaluar la tendencia en el tiempo del ictus&#46; Tanto la tasa global como la CPA se calcularon mediante la distribuci&#243;n de Poisson y fueron presentados con intervalo de confianza &#40;IC&#41; del 95&#37;&#46; Se consider&#243; como estad&#237;sticamente significativos p-valores &#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="par0035" class="elsevierStylePara elsevierViewall">Se identificaron 4&#46;420 casos con diagn&#243;stico de ictus seg&#250;n los criterios establecidos entre el 1 enero de 2010 y el 31 de diciembre de 2014&#46; Se eliminaron 23 casos correspondientes a sujetos cuya residencia estaba establecida fuera del &#225;rea sanitaria de Lleida&#46; Finalmente se incluyeron 4&#46;397 casos&#44; de los cuales 1&#46;617 &#40;36&#44;8&#37;&#41; fueron &#8805;<span class="elsevierStyleHsp" style=""></span>80 a&#241;os&#59; 3&#46;969 &#40;90&#44;3&#41; sujetos sufrieron un ictus&#44; mientras que 1&#46;741 &#40;39&#44;6&#37;&#41; casos correspondieron a mujeres&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">La tasa de incidencia cruda &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41; oscil&#243; entre los 192 &#40;IC 95&#37;&#58; 179-205&#41; en 2012 y los 211 &#40;IC 95&#37;&#58; 197-224&#41; en 2013 casos cada 100&#46;000 habitantes&#46; Las tasas estandarizadas por edad&#44; utilizando la poblaci&#243;n de referencia mundial&#44; oscilaron entre los 93 &#40;IC 95&#37;&#58; 86-100&#41; en 2012 y los 104 &#40;IC 95&#37;&#58; 96-11&#41; en 2013 casos cada 100&#46;000 habitantes&#46; En todos los a&#241;os&#44; las tasas de incidencia fueron significativamente mayores entre los varones en comparaci&#243;n con las mujeres&#46; Igualmente&#44; la tasa de incidencia increment&#243; de forma significativa con la edad&#44; ascendiendo a m&#225;s de 1&#46;000 casos cada 100&#46;000 habitantes en mayores de 79 a&#241;os&#46; La tasa de incidencia cruda se mantuvo estable durante los 5 a&#241;os estudiados&#58; CPA&#58; 0&#44;7 &#40;IC 95&#37;&#58; &#8722;1&#44;4-2&#44;8&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;54&#41;&#46; Al analizar las tendencias por grupos de edad &#40;<a class="elsevierStyleCrossRef" href="#fig0005">figura</a>&#41; se observ&#243; una tendencia decreciente en el grupo de 70 a 74 a&#241;os &#40;CPA&#58; &#8722;5&#44;2 &#91;IC 95&#37;&#58; &#8722;10&#44;8-0&#44;7&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;08&#93;&#41;&#46; Al tener en cuenta adem&#225;s el sexo&#44; se observ&#243; un incremento estad&#237;sticamente significativo en las mujeres pertenecientes a los grupos de edad de 45 a 49 a&#241;os &#40;CPA&#58; 31&#44;0 &#91;IC 95&#37;&#58; 2&#44;2-8&#44;1&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;03&#93;&#41; y un decremento en el grupo de edad de 70 a 74 a&#241;os &#40;CPA&#58; &#8722;18&#44;9 &#91;IC 95&#37;&#58; &#8722;26&#44;8-10&#44;2&#59; p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;01&#93;&#41;&#46; En los varones se detect&#243; un incremento significativo en el grupo de 65 a 69 a&#241;os &#40;CPA&#58; 9&#44;2 &#91;IC 95&#37;&#58; 0&#44;5-18&#44;7&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;04&#93;&#41;&#46; Las <a class="elsevierStyleCrossRefs" href="#tbl0010">tablas 2 y 3</a> muestran los resultados referentes a los ictus isqu&#233;micos y los ictus hemorr&#225;gicos&#44; respectivamente&#46; La incidencia de ictus isqu&#233;mico se mantuvo estable &#40;CPA&#58; 0&#44;62 &#91;IC 95&#37;&#58; &#8722;1&#44;6-2&#44;9&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;58&#93;&#41;&#46; En cambi&#243;&#44; se identific&#243; un incremento leve en el CPA en el ictus hemorr&#225;gico &#40;CPA&#58; 0&#44;94 &#91;IC 95&#37;&#58; &#8722;5&#44;62-7&#44;95&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#93;&#41;&#46; En los varones se detect&#243; una tendencia al incremento de la incidencia del ictus isqu&#233;mico en los grupos etarios de 40 a 44 a&#241;os &#40;CPA&#58; 23&#44;4 &#91;IC 95&#37;&#58; &#8722;0&#44;1-52&#44;2&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#93;&#41; y de 65 a 69 a&#241;os &#40;CPA&#58; 7&#44;8 &#91;IC 95&#37;&#58; &#8722;1&#44;1-17&#44;5&#59; p&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;<span class="elsevierStyleHsp" style=""></span>009&#93;&#41;&#46; En las mujeres&#44; se evidenci&#243; un incremento en los grupos de 45 a 49 &#40;CPA&#58; 41&#44;6 &#91;IC 95&#37;&#58; 6&#44;1-88&#44;9&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;02&#93;&#41; y de 55 a 59 a&#241;os &#40;CPA&#58; 18&#44;7 &#91;IC 95&#37;&#58; &#8722;2&#44;5-44&#44;6&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#44;09&#93;&#41;&#46; Tanto la incidencia del ictus isqu&#233;mico como la del hemorr&#225;gico incrementaron con la edad y con el sexo var&#243;n&#46; As&#237;&#44; el 60&#44;1&#37; de los ictus isqu&#233;micos acontecieron en varones mientras que 57&#44;7&#37; de los ictus hemorr&#225;gicos fueron varones&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="tbl0015"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discusi&#243;n</span><p id="par0045" class="elsevierStylePara elsevierViewall">Desarrollamos un estudio de incidencia en nuestra provincia de Lleida siguiendo la metodolog&#237;a id&#243;nea para este menester<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">10</span></a>&#46; En &#233;l obtuvimos una tasa de incidencia cruda elevada de entre 192 y 211 casos cada 100&#46;000 habitantes y a&#241;o&#46; Nuestra incidencia cruda es mayor de la observada en otras regiones europeas como Irlanda<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">22</span></a>&#44; Francia<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">23</span></a>&#44; Inglaterra<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">24&#44;25</span></a> o el sur de Italia<a class="elsevierStyleCrossRefs" href="#bib0305"><span class="elsevierStyleSup">26&#44;27</span></a>&#44; similar a la de ciertas regiones de Alemania<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">28</span></a> e inferior a regiones del Norte de Italia<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">29</span></a>&#44; Este de Europa<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">30</span></a> y Escocia<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">31</span></a>&#46; En comparaci&#243;n con estudios de referencia realizados en Espa&#241;a como el IBERICTUS o el ISISCOG<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">11</span></a>&#44; nuestra incidencia tambi&#233;n fue mayor<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">12</span></a>&#46; Esta incidencia elevada de ictus se puede explicar por la distribuci&#243;n de la pir&#225;mide de poblaci&#243;n de nuestra regi&#243;n que muestra una poblaci&#243;n envejecida&#46; En este sentido es significativo que una de cada 3 personas identificadas fueran mayor de 80 a&#241;os&#46; Estudios poblacionales en regiones pr&#243;ximas a la nuestra como el &#225;rea de Tarragona donde se incluyeron solo sujetos &#62;<span class="elsevierStyleHsp" style=""></span>60 a&#241;os detectaron incidencias crudas claramente elevadas<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">17</span></a>&#46; En cambio&#44; las tasas de incidencia ajustada son similares a las de la mayor&#237;a de pa&#237;ses europeos y claramente inferiores a las de pa&#237;ses en desarrollo<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">En nuestra poblaci&#243;n&#44; durante los 4 a&#241;os estudiados&#44; observamos una esperada relaci&#243;n con la edad&#46; Este hecho est&#225; claramente respaldado por la literatura ya que es observado en la gran mayor&#237;a de estudios<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">4&#44;16&#44;32</span></a>&#46; La incidencia incrementa de forma significativa a partir de los 65 a&#241;os&#44; y este incremento es exponencial a partir de los 85 a&#241;os&#44; tanto para los ictus isqu&#233;micos como para los hemorr&#225;gicos&#46; En personas del grupo etario de 80 a 84 a&#241;os la incidencia cruda llega a ser de 1&#46;316 casos cada 100&#46;000 habitantes&#46; Igualmente&#44; se observ&#243; una clara relaci&#243;n con el sexo&#46; As&#237;&#44; la incidencia entre los varones oscil&#243; entre 226 y 251 casos por cada 100&#46;000 habitantes y&#44; en cambio&#44; entre las mujeres oscil&#243; entre 153 y 169 casos por cada 100&#46;000 habitantes&#46; La relaci&#243;n con el sexo fue clara para los ictus isqu&#233;micos a partir de los 45 a&#241;os&#44; pero no para los ictus hemorr&#225;gicos&#46; La relaci&#243;n entre el sexo masculino y la incidencia de ECV est&#225; bien documentado<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">3&#44;33&#44;34</span></a> y demostrado en estudios espa&#241;oles como el IBERICTUS<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">12</span></a>&#44; ISISCOG<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">11</span></a> y el realizado en Tarragona<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">13</span></a>&#46; Los factores de riesgo para desarrollar la ECV difieren entre los sexos&#46; En mujeres es m&#225;s prevalente el ictus isqu&#233;mico de origen cardioemb&#243;lico y tienen una edad mayor que los varones<a class="elsevierStyleCrossRefs" href="#bib0340"><span class="elsevierStyleSup">33&#44;35</span></a>&#46; En estudios que analizan la evoluci&#243;n de la incidencia en funci&#243;n del sexo parece existir una tendencia a la disminuci&#243;n de la misma en mujeres<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">3</span></a>&#46; En nuestro trabajo no hubo diferencias significativas en la incidencia global ni la incidencia por sexos de los cinco a&#241;os analizados&#46; S&#237; se observ&#243; una tendencia al incremento leve de la incidencia del ictus hemorr&#225;gico&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Entre las principales limitaciones del estudio destaca el hecho que la base de informaci&#243;n fue los listados del CMBD de urgencias y de las altas hospitalarias&#44; por lo que todos aquellos pacientes que no acudieron al servicio de urgencias y tuvieron un ictus no fueron incluidos&#46; No se identificaron los casos de primer ictus de aquellos con antecedentes de ECV&#46; De esta forma puede ser que se confundan casos incidentes con casos prevalentes&#46; Igualmente&#44; no se han analizado los factores de riesgo vascular de cada caso&#46; Esta informaci&#243;n hubiese sido valiosa para explicar las diferencias en la incidencia por edad y sexo&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">El ictus sigue siendo una causa principal de muerte y una de las mayores causas de la carga global de la enfermedad a nivel mundial&#46; La realizaci&#243;n de un estudio de incidencia en nuestra zona nos proporciona una informaci&#243;n valiosa de su impacto en la salud p&#250;blica&#46; El an&#225;lisis de las tasas brutas y ajustadas obtenidas nos permite concluir que el impacto de la ECV en Lleida es equiparable a otras regiones europeas&#44; pero que el envejecimiento de la poblaci&#243;n se traduce en una incidencia bruta elevada que se mantiene estable en los 5 a&#241;os analizados&#46; Estos datos deben de tenerse en cuenta a la hora de organizar pol&#237;ticas de salud p&#250;blica en nuestra regi&#243;n&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Financiaci&#243;n</span><p id="par0075" class="elsevierStylePara elsevierViewall">Ag&#232;ncia de Gesti&#243; d&#8217;Ajuts Universitaris i de Recerca&#44; Generalitat de Catalunya &#40;2017 SGR 1628&#41;&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Conflicto de intereses</span><p id="par0065" class="elsevierStylePara elsevierViewall">Ninguno de los autores refiere conflicto de intereses&#46;</p></span></span>"
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    "fechaRecibido" => "2019-06-11"
    "fechaAceptado" => "2019-10-13"
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            3 => "Ictus"
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            0 => "Cerebrovascular disease"
            1 => "Elderly"
            2 => "Incidence"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Objetivo</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Determinar la incidencia de la enfermedad cerebrovascular &#40;ECV&#41; y su tendencia en el &#225;rea sanitaria de Lleida&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Estudio de cohortes de base poblacional que incluy&#243; a toda la poblaci&#243;n del &#225;rea sanitaria de Lleida &#40;440&#46;000 personas&#41;&#46; Se utilizaron los listados del Conjunto M&#237;nimo B&#225;sico de Datos &#40;CMBD&#41; de urgencias y de las altas hospitalarias en el periodo comprendido entre enero de 2010 y diciembre de 2014&#46; Se seleccionaron todos los episodios de ictus&#46; Se evaluaron las tasas brutas y las tasas estandarizadas por edad utilizando la poblaci&#243;n mundial como referencia&#46; Se excluyeron aquellos casos sin confirmaci&#243;n diagn&#243;stica por neuroimagen&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 4&#46;397 casos&#44; de los cuales 1&#46;617 &#40;36&#44;8&#37;&#41; fueron &#8805;<span class="elsevierStyleHsp" style=""></span>80 a&#241;os&#59; 3&#46;969 &#40;90&#44;3&#37;&#41; sujetos sufrieron un ictus isqu&#233;mico&#44; mientras que 1&#46;741 &#40;39&#44;6&#37;&#41; casos correspondieron a mujeres&#46; La tasa de incidencia cruda oscil&#243; entre los 192 &#40;intervalo de confianza &#91;IC&#93; del 95&#37;&#58; 179-205&#41; en 2012 y los 211 &#40;IC 95&#37;&#58; 197-224&#41; en 2013 casos cada 100&#46;000 habitantes&#46; Las tasas estandarizadas por edad oscilaron entre los 93 &#40;IC 95&#37;&#58; 86-100&#41; en 2012 y los 104 &#40;IC 95&#37;&#58; 96-111&#41; en 2013 casos por cada 100&#46;000 habitantes&#46; En todos los a&#241;os&#44; las tasas de incidencia fueron significativamente mayores entre los varones en comparaci&#243;n con las mujeres&#59; y se incrementaron con la edad&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">El impacto de la ECV en Lleida es equiparable a otras regiones europeas&#44; pero que el envejecimiento de la poblaci&#243;n se traduce en una incidencia bruta elevada que se mantiene estable en los 5 a&#241;os analizados&#46;</p></span>"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">This study aimed to determine the incidence and trends of cerebrovascular disease &#40;CVD&#41; in the healthcare district of Lleida&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We performed a population-based prospective cohort study including the entire population of the healthcare district of Lleida &#40;440&#160;000 people&#41;&#46; Information was gathered from the minimum basic data set from the emergency department and hospital discharges for the period from January 2010 to December 2014&#46; All types of stroke were included&#46; We evaluated crude and age-standardised rates using the world population as a reference&#46; Patients without neuroimaging confirmation of the diagnosis were excluded&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We identified 4397 patients&#58; 1617 &#40;36&#46;8&#37;&#41; were aged 80 years or over&#59; 3969 &#40;90&#46;3&#37;&#41; presented ischaemic stroke&#44; and 1741 &#40;39&#46;6&#37;&#41; were women&#46; The crude incidence rate ranged from 192 &#40;95&#37; confidence interval &#91;CI&#93;&#44; 179-205&#41; to 211 &#40;95&#37;&#160;CI&#44; 197-224&#41; cases per 100&#160;000 population&#44; in 2012 and 2013&#44; respectively&#46; Age-standardised rates ranged from 93 &#40;95&#37;&#160;CI&#44; 86-100&#41; to 104 &#40;95&#37;&#160;CI&#44; 96-111&#41; cases per 100&#160;000 population&#44; in 2012 and 2013&#44; respectively&#46; For all years&#44; incidence rates increased with age&#44; and were significantly higher among men than among women&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusion</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The impact of CVD in Lleida is comparable to that observed in other European regions&#46; However&#44; population ageing induces a high crude incidence rate&#44; which remained stable over the five-year study period&#46;</p></span>"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Comparaci&#243;n de la incidencia cruda por grupos etarios y sexo para ictus &#40;A&#41;&#44; ictus isqu&#233;mico &#40;B&#41; e ictus hemorr&#225;gico &#40;C&#41;&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Incidencia ajustada &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Incidencia de ictus seg&#250;n grupos etarios&#46; Incidencia bruta e incidencia ajustada por edad</p>"
        ]
      ]
      2 => array:8 [
        "identificador" => "tbl0010"
        "etiqueta" => "Tabla 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at2"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">a&#58; a&#241;os&#59; APC&#58; porcentaje cambio anual&#59; IC&#58; intervalo de confianza&#59; ICR&#58; incidencia cruda&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="13" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Grupos de edad</th><th class="td" title="\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">0-34 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">35-39 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">40-44 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">45-49 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">50-54 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">55-59 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">60-64 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">65-69 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">70-74 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">75-79 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">80-84 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&#62;<span class="elsevierStyleHsp" style=""></span>85 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Global&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">A&#241;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Incidencia cruda &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Incidencia ajustada &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="16" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">2010</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Todos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;5&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;10&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;34&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;45&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">29 &#40;102&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">49 &#40;205&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">55 &#40;257&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">66 &#40;363&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">107 &#40;690&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">167 &#40;931&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">179 &#40;1&#46;253&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">121 &#40;970&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">813&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">185 &#40;172-198&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">90 &#40;83-98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Var&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;4&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;4&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;31&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;80&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 127&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">40 &#40;325&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;361&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;436&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#40;880&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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            ]
          ]
        ]
        "descripcion" => array:1 [
          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Incidencia de ictus isqu&#233;mico seg&#250;n grupos etarios&#46; Incidencia bruta e incidencia ajustada por edad</p>"
        ]
      ]
      3 => array:8 [
        "identificador" => "tbl0015"
        "etiqueta" => "Tabla 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at3"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
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        "tabla" => array:2 [
          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">a&#58; a&#241;os&#59; APC&#58; porcentaje cambio anual&#59; IC&#58; intervalo de confianza&#59; ICR&#58; incidencia cruda&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="13" align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Grupos de edad</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">0-34 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">35-39 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">40-44 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">45-49 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">50-54 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">55-59 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">60-64 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">65-69 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">70-740 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">75-79 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">80-84 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&#62;<span class="elsevierStyleHsp" style=""></span>85 a&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Global&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">A&#241;o&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos &#40;ICR&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Casos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Incidencia cruda &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Incidencia ajustada &#40;IC 95&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="16" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">2010</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Todos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;1&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;2&#44;85&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;9&#44;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;17&#44;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;20&#44;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;28&#44;06&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;38&#44;55&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">11 &#40;71&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;78&#44;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;63&#44;01&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;96&#44;19&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;13-21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;7-12&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Var&#243;n&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;5&#44;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;5&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;6&#44;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;32&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;47&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;45&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;69&#44;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;88&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4 &#40;66&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;135&#44;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;12-23&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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          "es" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Incidencia de ictus hemorr&#225;gico seg&#250;n grupos etarios&#46; Incidencia bruta e incidencia ajustada por edad</p>"
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Información del artículo
ISSN: 02134853
Idioma original: Español
DOI:10.1016/j.nrl.2019.10.012
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