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Inicio Neurología (English Edition) Descriptive analysis of the annual cost of treating spasticity with different ty...
Información de la revista
Vol. 37. Núm. 8.
Páginas 653-660 (octubre 2022)
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1476
Vol. 37. Núm. 8.
Páginas 653-660 (octubre 2022)
Original article
Open Access
Descriptive analysis of the annual cost of treating spasticity with different types of botulinum toxin A
Análisis descriptivo de coste de tratamiento de la espasticidad con diferentes tipos de toxina botulínica A, a lo largo de un año
Visitas
1476
D. Hernández Herreroa,b,
Autor para correspondencia
, J.C. Miangolarra Pagec,d
a Servicio de Medicina Física y Rehabilitación, Hospital Universitario La Paz, Madrid, Spain
b Escuela Internacional de Doctorado, Universidad Rey Juan Carlos, Madrid, Spain
c Departamento de Medicina Física y Rehabilitación, Universidad Rey Juan Carlos, Madrid, Spain
d Servicio de Rehabilitación y Medicina Física del Hospital Universitario de Fuenlabrada, Fuenlabrada (Madrid), Spain
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Abstract
Introduction

Botulinum toxin A is the first-line treatment for localised spasticity. However, the economic impact of this treatment is not fully known. This study aimed to describe the real costs of botulinum toxin A for the treatment of adult patients with spasticity at a spasticity clinic pertaining to a rehabilitation service, over a period of one year.

Methods

We retrospectively reviewed all medical procedures carried out during the year 2017. We collected data on the type of toxin used (incobotulinumtoxin A, onabotulinumtoxin A, or Abobotulinumtoxin A), the number of units injected, the anatomical region, and the time elapsed between infiltrations. The costs of medication and indirect costs, such as staff and consumables, were also calculated.

Results

This is the first study to describe the real costs of botulinum toxin treatment of spasticity in adult patients in Spain. In 2017, 510 infiltration procedures were performed in 164 patients. The total cost of treating spasticity in our service was 116 789.70. The mean annual cost per patient was 603.64 for onabotulinumtoxin A, 642.69 for abobotulinumtoxin A, and 707.59 for incobotulinumtoxin A.

Conclusions

Our economic study of real clinical practice is consistent with the theoretical models published in the literature. The different characteristics of each toxin and the inability to establish an equivalence between the units of each drug prevents us from directly comparing these costs.

Keywords:
Botulinum toxin A
Spasticity
Cost analysis
Spain
Resumen
Introducción

La toxina botulínica A es el tratamiento de elección para la espasticidad localizada. Sin embargo, no se tiene un conocimiento real de su repercusión económica. El objetivo de este trabajo es describir los costes reales del tratamiento de la espasticidad en adultos con toxina botulínica A en una consulta de espasticidad de un Servicio de Rehabilitación, a lo largo de un año.

Métodos

Se ha realizado la revisión retrospectiva de todos los actos médicos llevados a cabo a lo largo del año 2017. Se han recogido el tipo de toxina utilizado (incobotulinumtoxin A, onabotulinumtoxin A, abobotulinumtoxin A), las unidades inyectadas, la región anatómica y el tiempo transcurrido entre infiltraciones. Se han obtenido los costes de la medicación y los costes indirectos, como los de personal o fungibles.

Resultados

Este es el primer trabajo que describe los costes reales del tratamiento de la espasticidad en adultos con toxina botulínica A en España. En 2017 se realizaron 510 actos de infiltración en 164 pacientes. El coste total de tratamiento de espasticidad en nuestro Servicio fue de 116.789,70 . El coste medio anual por paciente fue 603,64 para onabotulinumtoxin A, 642,69 para AbotoxA y 707,59 para incobotulinumtoxin A.

Conclusiones

Nuestro estudio económico de actividad clínica real sigue una pauta similar a la descrita en los modelos teóricos publicados en la literatura. Las diferentes características de cada toxina y la imposibilidad de establecer una equivalencia entre las unidades de cada una de ellas impiden la comparación directa de estos costes.

Palabras clave:
Toxina botulínica A
Espasticidad
Análisis de costes
España
Texto completo
Introduction

Spasticity frequently appears over the course of upper motor neuron disease, causing pain, functional limitations, and difficulty attending to personal hygiene.1

Spasticity treatment includes a wide range of options, from physical medicine and rehabilitation techniques to surgery.2 Regarding pharmacological treatment, spasticity may be treated with oral (tizanidine, baclofen, etc) or intrathecal drugs (baclofen). However, the treatment of first choice for focal spasticity is intramuscular botulinum toxin A (BoNT-A) injection.3,4

Three types of BoNT-A are available in Spain, from different pharmaceutical companies and with different characteristics, preventing direct comparison between them. All 3 types have been shown to be efficacious in the treatment of focal spasticity.5 IncobotulinumtoxinA (IncotoxA; Xeomin®, Merz Pharmaceuticals) includes no complexin proteins (haemagglutinins) and does not require cold storage. OnabotulinumtoxinA (OnatoxA; Botox®, Allergan) and abobotulinumtoxinA (AbotoxA; Dysport®, Ipsen Biopharm), in contrast, must be stored under refrigeration.6 The conversion ratio between IncotoxA and OnatoxA is 1:1, whereas the conversion ratio for IncotoxA and AbotoxA is 1:3.7 This ratio was established by indirect methods, since no standardised tests are available to compare these products. Furthermore, AbotoxA seems to be more cost-effective.3 Roze et al.8 compared the cost of treating upper-limb spasticity based on the recommended doses of OnabotA and AbotoxA in 19 countries, including Spain; in all cases, treatment with AbotoxA was found to be less costly.

One of the characteristics of this treatment is that infiltrations must be performed periodically, with medical appointments either scheduled in advance every 3-4 months, or offered on demand, when spasticity symptoms reappear and affect the patient’s daily life.6

The dose injected at each session depends on the patient’s clinical status at the consultation prior to treatment and on the effectiveness of previous treatments.1 Therefore, a fixed maintenance dose cannot be established and doses usually change from session to session.

The need for periodic injections and the changes in dosage between sessions make it difficult to estimate the cost of treatment over time.

We aimed to calculate the costs of treatment with BoNT-A over one year in a spasticity unit for adults from the rehabilitation department of a tertiary hospital of the Spanish National Health System.

Material and methods

The study was approved by our hospital’s ethics committee.

Our department has a spasticity unit that treats adult patients, providing outpatient consultations 2 days per week. We retrospectively reviewed the medical histories of all patients receiving treatment at the spasticity unit in 2017. The study included those patients treated with BoNT-A.

Our spasticity unit administers all 3 types of BoNT-A (OnatoxA, IncotoxA, and AbotoxA); the specific treatment selected depends on the judgement and experience of the 2 physicians leading the unit. BoNT-A is used in accordance with Spanish Royal Decree-Law 16/2012 on resource optimisation. Due to its form of presentation, the entire vial must be reconstituted at once; therefore, if the whole dose is not administered, the remaining drug is stored appropriately for subsequent use in another patient.9

BoNT-A is administered by ultrasound-guided injection at the consultation. At our unit, the mean duration of consultations is 25 minutes for patients with upper-limb spasticity and 30 minutes for those with lower-limb spasticity (this includes examination, patient transfer, undressing and dressing, and BoNT-A infiltration). Treatment is administered by a specialist, the head of a hospital department in all cases (this has been considered in the cost estimation), with the assistance of a nurse. During the study period (2017), 2 specialists were responsible for administering all treatments at the spasticity unit.

We reviewed patient’s medical histories to gather data on the type of BoNT-A used, dose, date of infiltration, and the anatomical region treated. Two anatomical regions were considered: upper limbs and lower limbs.

From an administrative viewpoint, the unit schedules periodical consultations (approximately every 4 months) with patients receiving BoNT-A. The number of units of BoNT-A infiltrated in each consultation depends on the patient’s clinical status, examination results at the time of infiltration, and patients’ and their relatives’ degree of satisfaction with the outcomes of the previous infiltration procedure.

We also obtained information from the hospital’s purchasing department on the prices of the different types of BoNT-A used at our centre.

The calculation of annual cost included the salaries of the healthcare professionals involved in the treatment and the cost of expendable materials (needles, syringes, etc). We did not account for such indirect costs as equipment depreciation or other general costs (water, electricity, etc). As in previous studies, these costs were not considered in the comparison of the different types of BoNT-A, since the procedure is similar regardless of the type of BoNT-A administered and the associated costs present no significant differences.

The costs of the physician and nurse are based on the salary table published by the Madrid regional health ministry in the Official Gazette of the Community of Madrid for 2017,10 and a total of 1465 working hours per year.

Microsoft® Excel was used for data collection and handling and cost calculation. Statistical analysis was performed with Stata, version 15. We used ANOVA to compare quantitative data between the 3 groups, and the t test with Bonferroni correction for a posteriori pairwise comparisons.

Results

In 2017, a total of 763 medical procedures were performed at the spasticity unit. Of these, 253 were intrathecal baclofen pump refills and 510 were BoNT-A infiltrations. A total of 169 patients received treatment with BoNT-A. We excluded 5 patients: 2 who received treatment with BoNT-A for other indications and 3 who received different types of BoNT-A for unknown reasons. Of the 164 patients included, 138 received infiltrations in the lower limbs and 84 in the upper limbs. In 129 medical procedures, 55 patients received BoNT-A in both the upper and the lower limbs.

Table 1 describes our patient sample and the doses administered for each type of BoNT-A.

Table 1.

Distribution of patients by type of botulinum toxin A received and doses administered.

    OnatoxA  AbotoxA  IncotoxA 
Patients  161  53  60  48 
Women/men  67/94  26/27  20/40  21/27 
Mean age (SD), yearsa  42 (21.4)  32 (19.3)  41 (21.8)  53 (17.6) 
Upper limbs/lower limbs  81/133  21/42  31/51  29/40 
Time between infiltrations during the study period
Mean (SD), daysb  134.77 (31.9)  143.60 (35.5)  133.39 (28.38)  127.10 (31.1) 
Units used in each infiltration procedure
All procedures conducted in 2017
Average dose    308.95  914.23  425.97 
SD    145.56  377.45  169.99 
Max/min dose    900/30  1850/250  760/100 
1st infiltration of the year
No. patients    53  60  48 
Average dose    273.77  879.75  387.71 
SD    129.75  386.53  176.01 
Max/min dose    650/30  1850/250  760/100 
2nd infiltration of the year
No. patients    42  54  35 
Average dose    318.1  859.72  394.29 
SD    147.02  373.19  158.82 
Max/min dose    900/100  1500/250  700/100 
3rd infiltration of the year
No. patients    23  33  21 
Average dose    343.91  917.42  410.24 
SD    171.25  381.89  177.94 
Max/min dose    900/100  1500/450  750/150 
4th infiltration of the year
No. patients   
Average dose    300  1000  511.67 
Max/min dose        675/310 
Total per patient and year
No. patients    53  60  48 
Average dose    680.75  2174.75  886.67 
SD    466.41  1160.34  595.68 
Max/min dose    2300/30  4850/325  2500/250 

SD: standard deviation.

a

Age at the time of the first infiltration of the study period. ANOVA: P > .000; OnatoxA vs AbotoxA: P = .05; OnatoxA vs IncotoxA: P = .000; AbotoxA vs IncotoxA: P = .004.

b

ANOVA: P = .013; OnatoxA vs AbotoxA: P = .146; OnatoxA vs IncotoxA: P = .012; AbotoxA vs IncotoxA: P = .706.

OnatoxA: 53 patients. Mean of 2.2 sessions during the study period. The mean time between infiltrations was 143.6 days. The mean number of units administered in each session was 308.95. The mean total number of units administered to each patient over one year was 680.75.

AbotoxA: 60 patients. Mean of 2.4 sessions during the study period. The mean time between infiltrations was 133.4 days. The mean number of units administered in each session was 914.23. The mean total number of units administered to each patient over one year was 2174.75.

IncotoxA: 48 patients. Mean of 2.4 sessions during the study period. The mean time between infiltrations was 127.1 days. The mean number of units administered in each session was 425.97. The mean total number of units administered to each patient over one year was 889.67.

Table 2 lists the costs associated with the 3 types of BoNT-A, whereas Table 3 presents the cost of healthcare professionals’ salaries. For each infiltration procedure, we considered the costs of the following expendable materials: 2 syringes (2 × 0.027), 2 needles (2 × 0.06), and 1 serum vial (0.723), resulting in a total cost of 0.90 in expendable materials per procedure.

Table 2.

Cost of the 3 types of botulinum toxin A used in our study.

  OnatoxA  AbotoxA  IncotoxA 
Price per vial  88.673  147.763  79.803 
Units per vial  100  500  100 
Price per unit  0.88673  0.295526  0.79803 
Table 3.

Healthcare staff costs calculated based on the salary table published in the Official Gazette of the Community of Madrid for 2017.

  Annual salary  Salary per minute  Direct cost applicable
      Upper limbs (25 min)  Lower limbs (30 min) 
Head of department  48 170.16  0.54  13.5  16.2 
Nurse  25 150.08  0.286  7.15  8.58 

Table 4 summarises the costs of using BoNT-A in 2017.

Table 4.

Cost of treatment with botulinum toxin A for spasticity per patient and year, depending on the maximum and minimum doses used.

  OnatoxA  AbotoxA  IncotoxA 
Mean dose per session
Units  308.95  914.22  425.97 
Cost  273.95  270.17  339.94 
Total per patient and year
Units  680.75  2174.75  886.67 
Cost  603.64  642.69  707.59 
Maximum dose
Units  900  1850  760 
Cost  798.06  546.72  606.50 
Minimum dose
Units  30  250  100 
Cost  26.60  73.88  79.80 

The mean cost of treatment per patient in 2017 was 603.64 for OnatoxA, 642.69 for AbotoxA, and 707.59 for IncotoxA.

Overall, the mean cost of treatment with BoNT-A in our unit is 643.29, whereas the annual cost of the drug is 104 519.09.

Table 5 shows data on patients who received the same dose throughout the year. This is an indirect indicator that the optimal dose has been achieved; it is therefore to be expected that the optimal dose will be maintained over time, unless the patient’s clinical status worsens. This was the case in 49% of the patients receiving OnatoxA, 43.3% of those receiving AbotoxA, and 45.8% of those treated with IncotoxA. The annual cost of treatment in these patients was 690.28, 642.71, and 817.03, respectively. In the subgroup of patients receiving the same dose during the whole study period, the mean total cost of treatment was 711.25.

Table 5.

Cost of treatment in patients receiving the same dose throughout the whole study period.

  OnatoxA  AbotoxA  IncotoxA 
No. patients  26  26  22 
Mean annual dose per patient
Units  778.46  2174.81  1023.81 
Cost  690.28  642.71  817.03 
Mean annual dose per session
Units  297.65  856.74  413.46 
Cost  263.94  253.19  329.95 

Table 6 presents the total annual cost of treatment, including personnel and expendable material costs. In 2017, the total cost of spasticity treatment with BoNT-A in our unit was 116 789.70, which represents 5.23% of the unit’s total annual budget for 2017.

Table 6.

Total annual cost of treatment.

  OnatoxA  AbotoxA  IncotoxA  Total 
No. sessions for upper-limb spasticity  47  79  67  193 
No. sessions for lower-limb spasticity  97  127  93  317 
Cost of healthcare professionals         
Physician  2205.9  3123.9  2411.1  7740.09 
Nurse  1139.21  1654.51  1276.99  4070.71 
Cost of expendable materials  129.6  185.4  144  459 
Cost of botulinum toxin A  31 993.22  38 561.71  33 964.16  104 519.09 
Total  35 467.93  43 525.52  37 796.25  116 789.70 
Discussion

To our knowledge, this is the first study into the real costs of spasticity treatment for adults to be conducted in Spain.

According to a previous study,11 the annual cost of treatment with BoNT-A in Spain in 2013 ranged from 265 to 2120 per patient, depending on the indication, dose, and type of BoNT-A used. Costs were established according to diagnosis, theoretical mean dose, and muscles infiltrated with the 3 types of BoNT-A analysed. The cost of treatment for upper-limb spasticity in adult patients in that study was 291.43 for OnatoxA at initial doses, 702.08 for OnatoxA at average doses, and 1271.69 for AbotoxA at maximum doses, for the least costly procedures. In the case of children with cerebral palsy, costs amounted to 331.17 for initial and average doses and 529.87 for maximum doses; in all cases, OnatoxA was the least costly drug. Our study considered the real doses administered. AbotoxA is less costly than the other 2 types of BoNT-A, taking into account individual infiltration procedures, and OnatoxA is the least costly if we consider the whole treatment period. However, the study by de Andrés-Nogales et al.11 is not comparable to our own since it presents only theoretical data, whereas our study presents data on the real doses used in clinical practice.

Roze et al.8 studied the theoretical cost of treatment for upper-limb spasticity in 19 countries; AbotoxA was found to be the least costly option in 18 of these. This finding is consistent with our results: in our study, AbotoxA was less costly than OnatoxA and IncotoxA for each individual session, although this was not the case for the whole treatment period.

Tapias et al.5 analysed the cost of treatment with BoNT-A for pes equinus in children with cerebral palsy. They only compared OnatoxA and AbotoxA, and concluded that the latter was the less costly treatment (631.23 vs 839.56). IncotoxA was not included in the comparison since the drug is not indicated for children. These results stand in contrast with our own. This may be due to the fact that while the retrospective study by Tapias et al.5 was based on real doses, it analysed a single problem (pes equinus in cerebral palsy), whereas our patients were adults with spasticity of various aetiologies. Furthermore, the study by Tapias et al. did not apply the Spanish Royal Decree-Law 16/2012 on resource optimisation, which allows the same vial to be used for different patients. In a similar study including the same type of patients (children with cerebral palsy), Houltram et al.12 calculated that treatment with BoNT-A cost $595 for hemiplegia and $1045 for diplegia, and was effective and safe, with only a slight increase in direct medical costs per patient per year.

Ward et al.13 studied a decision tree model based on the Delphi method in the United Kingdom, and compared the outcomes of oral therapy, BoNT-A alone, and BoNT-A as a second-line treatment after oral therapy. The cost of BoNT-A as a first-line treatment was estimated at £942; the authors concluded that first-line BoNT-A is effective for the treatment of post-stroke spasticity. The study also calculated a mean time of 30 minutes per patient contact, with a cost of £54.50 for physician care and £19.50 for nurse care. Patient contact times were similar to those observed in our unit, although physician care is considerably more costly in the study by Ward et al.13 (£54.50 vs 16.20). Furthermore, while Ward et al. report a mean of 4 sessions per year, patients in our sample were attended a mean of 2.32 times per year.

Schnitzler et al.4 estimated the cost of BoNT-A treatment in France at 1559 per year and 652.23 per session. They used OnatoxA and AbotoxA, making no distinction between the 2 drugs. Cost estimations include the price of BoNT-A and also such indirect costs as staffing and equipment costs. In that study, healthcare staff costs (57 046/year for physicians) are similar to our estimates (13.5/session for upper-limb spasticity and 16.2/session for lower-limb spasticity). It should be noted that France and Spain have different healthcare funding systems.

The studies available in the literature also present differences in the infiltration schedule. In our study, we scheduled periodic consultations at our unit, with a mean time between infiltrations of 134.77 days. Although the different types of BoNT-A presented statistically significant differences, these cannot be considered clinically significant, given the consultation scheduling system used at our unit. Sanz-Granda et al.6 compared the outcomes of 2 different forms of scheduling (fixed vs flexible intervals) for the treatment of blepharospasm and cervical dystonia, and concluded that IncotoxA at flexible intervals was more cost-effective than OnatoxA at fixed intervals. The study conducted by Arroyave et al.14 in children with cerebral palsy in Mexico established a period between infiltrations ranging from 84 to 138 days.

In the assessment of outcomes by type of BoNT-A and mean age, although statistical analysis yielded significant differences, these results are not valid from a clinical viewpoint due to the design of the study. Many patients had been receiving treatment before the study period, some since childhood, and the type of BoNT-A used frequently remained unchanged, which prevents us from establishing an association between age and type of BoNT-A. Furthermore, IncotoxA is not indicated for children, which may also explain the higher mean age in the group of patients treated with this type of BoNT-A.

Our study has a number of limitations.

Firstly, it is a retrospective study. Secondly, the decision to administer one type of toxin or another is based on the experience and subjective judgement of the physicians responsible for the treatment. Dose adjustment between sessions is based on treatment effectiveness, which is determined by clinical practice. We assumed that the 3 types of BoNT-A were equally effective and that dose adjustments in a single patient were due to fluctuations in clinical status rather than to underdosing.

Furthermore, the different types of BoNT-A used have different properties, composition, and storage requirements, and no study has established equivalence between units; it is therefore not possible to establish direct comparisons between drugs, even in terms of costs.15

Our department has a unit specialising in the management of adult patients with spasticity, with consultations held 2 days per week; this enables resource optimisation as vials can be used more efficiently. However, departments attending patients at normal consultations, rather than at specialised units, are more likely to waste units of BoNT-A due to the drug’s stringent storage requirements.

Randomised, prospective studies should be designed to evaluate the efficacy of this treatment with spasticity and quality of life scales. This would allow us to draw conclusions on the cost of spasticity treatment with BoNT-A in clinical practice with a view to making informed decisions about the most suitable intervention in each case.16

Conclusions

The use of BoNT-A for the treatment of spasticity in adult patients in our department shows a similar trend to those of previous studies: AbotoxA seems to be the least costly drug for individual sessions, whereas OnatoxA is the least costly over a one-year treatment period. Differences in pricing, the wide range of indications, and the inability to establish direct comparisons between the 3 types of BoNT-A analysed prevent us from recommending any specific drug solely based on economic criteria.

Funding

This study has received no specific funding from any public, commercial, or non-profit organisation.

Conflicts of interest

Dr Hernández has received travel expenses from Allergan, Ipsen, and Merz for attending congresses and courses, although he has received no compensation for participating in this study that might constitute a conflict of interest.

Dr Miangolarra Page has no conflicts of interest to declare.

Acknowledgements

The authors wish to thank Dr Moraleda Pérez, Dr Martínez Moreno, and Dr Garvín Ocampos for reviewing the manuscript.

References
[1]
G. Sheean.
Botulinum toxin treatment of adult spasticity: a benefit-risk assessment.
[2]
A. Esquenazi, A. Albanese, M.B. Chancellor, E. Elovic, K.R. Segal, D.M. Simpson, et al.
Evidence-based review and assessment of botulinum neurotoxin for the treatment of adult spasticity in the upper motor neuron syndrome.
[3]
F. Scaglione.
Conversion ratio between Botox®, Dysport®, and Xeomin® in Clinical Practice.
Toxins (Basel), 8 (2016),
[4]
A. Schnitzler, A. Ruet, S. Baron, J.C. Buzzi, F. Genet.
Botulinum toxin A for treating spasticity in adults: costly for French hospitals?.
Ann Phys Rehabil Med, 58 (2015), pp. 265-268
[5]
G. Tapias, M. Garcia-Romero, C. Crespo, M. Cuesta, C. Forne, S.I. Pascual-Pascual.
Cost-minimization analysis in the treatment of spasticity in children with cerebral palsy with botulinum toxin type A: an observational, longitudinal, retrospective study.
Farm Hosp, 40 (2016), pp. 412-426
[6]
A. Sanz-Granda, M.J. Marti, M.J. Catalan.
[Cost-utility analysis of two formulations of botulinum toxin type A in the treatment of blepharospasm and cervical dystonia in Spain] [artículo en español].
Rev Neurol, 67 (2018), pp. 465-472
[7]
R. Ravenni, D. De Grandis, A. Mazza.
Conversion ratio between Dysport and Botox in clinical practice: an overview of available evidence.
Neurol Sci, 34 (2013), pp. 1043-1048
[8]
S. Roze, H. Kurth, B. Hunt, W. Valentine, R. Marty.
Evaluation of the cost per patient per injection of botulinum toxin A in upper limb spasticity: comparison of two preparations in 19 countries.
Med Devices (Auckl), 5 (2012), pp. 97-101
[9]
Real Decreto-ley 16/2012 de 20 de abril de medidas urgentes para garantizar la sostenibilidad del Sistema Nacional de Salud y mejorar la calidad y seguridad de las prestaciones. BOE núm. 28, de 24 de abril de 2012 [Accessed 6 April 2019]. Available from: https://www.boe.es/eli/es/rdl/2012/04/20/16/con.
[10]
ORDEN de 14 de julio de 2017, de la Consejería de Economía, Empleo y Hacienda, por la que se dictan Instrucciones para la Gestión de las Nóminas del Personal de la Comunidad de Madrid para 2017. BOCM núm. 171 de 20 de julio de 2017 [Accessed 6 April 2019]. Available from: http://w3.bocm.es/boletin/CM_Orden_BOCM/2017/07/20/BOCM-20170720-16.PDF.
[11]
F. de Andrés-Nogales, A. Morell, J. Aracil, C. Torres, I. Oyagüez, M.A. Casado.
[Cost analysis of the use of botulinum toxin type A in Spain] [artículo en español].
Farm Hosp, 38 (2014), pp. 193-201
[12]
J. Houltram, I. Noble, R.N. Boyd, I. Corry, P. Flett, H.K. Graham.
Botulinum toxin type A in the management of equinus in children with cerebral palsy: an evidence-based economic evaluation.
Eur J Neurol, 8 (2001), pp. 194-202
[13]
A. Ward, G. Roberts, J. Warner, S. Gillard.
Cost-effectiveness of botulinum toxin type a in the treatment of post-stroke spasticity.
J Rehabil Med, 37 (2005), pp. 252-257
[14]
G. Arroyave Loaiza, E.C. Jarillo Soto, M.G. Garfias Garnica, D.B. Ribera Ibarra, J.A. Uribe Zamarripa.
Coste-beneficio del tratamiento farmacológico de la parálisis cerebral con espasticidad en México.
Rev Esp Salud Pública, 74 (2000), pp. 549-559
[15]
M. Field, A. Splevins, P. Picaut, M. van der Schans, J. Langenberg, D. Noort, et al.
AbobotulinumtoxinA (Dysport).
Toxins (Basel), 10 (2018),
[16]
S. Evers, M. Goossens, H. de Vet, M. van Tulder, A. Ament.
Criteria list for assessment of methodological quality of economic evaluations: consensus on health economic criteria.
Int J Technol Assess Health Care, 21 (2005), pp. 240-245

Please cite this article as: Hernández Herrero D, Miangolarra Page JC. Análisis descriptivo de coste de tratamiento de la espasticidad con diferentes tipos de toxina botulínica A, a lo largo de un año. Neurología. 2022;37:653–660.

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