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Inicio Revista Clínica de Periodoncia, Implantología y Rehabilitación Oral Empleo de Agentes Farmacológicos en Dentífricos como Moduladores de la Infecci...
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Vol. 1. Núm. 3.
Páginas 101-103 (noviembre 2008)
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Vol. 1. Núm. 3.
Páginas 101-103 (noviembre 2008)
Open Access
Empleo de Agentes Farmacológicos en Dentífricos como Moduladores de la Infección e Inflamación Periodontal
Use of Pharmacological Agents in Dentifrices for the Prevention of Periodontal Disease
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1496
P. Smith1,
Autor para correspondencia
psmith@med.puc.cl

Correspondencia autor: Marcoleta 391. Santiago, Chile. Laboratorio de Fisiología Periodontal Centro de Investigaciones Médicas, Carrera de Odontología. Facultad de Medicina Pontificia Universidad Católica de Chile.
, R. Arancibia1, J. Martínez2
1 Laboratorio de Fisiología Periodontal. Carrera de Odontología. Centro de Investigaciones Médicas (CIM). Facultad de Medicina Pontificia Universidad Católica de Chile. Chile
2 Laboratorio de Biología Celular. INTA, Universidad de Chile. Chile
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Resumen

La enfermedad periodontal causa importantes efectos deletéreos en la dentición humana, provocando la degradación del tejido de soporte periodontal y eventualmente la pérdida de la dentición. Por otro lado, existen evidencias que sugieren que esta infección puede comprometer la salud general del paciente. La prevención de esta enfermedad puede tener entonces importantes repercusiones en la salud pública y las herramientas para prevenir o controlar esta patología ameritan la implementación de medidas basadas en el autocuidado y la prevención por parte del propio paciente. Es en este sentido que el desarrollo de productos que faciliten el control de placa bacteriana y reduzcan los niveles de inflamación en el tejido periodontal podría tener efectos beneficiosos en la salud oral de nuestra comunidad. En la presente revisión se analiza el papel de agentes farmacológicos utilizados en dentífricos que pueden tener un efecto positivo en el control de la gingivitis y enfermedad periodontal.

Palabras clave:
Prevención
dentífrico
triclosán
enfermedad periodontal
Abstract

Periodontal disease may cause significant deleterious effects in human dentition including the destruction of the periodontal attachment system and eventually tooth loss. There is also a growing body of scientific evidence that suggests a role for periodontal infections in the deterioration of the systemic health. Therefore, prevention of periodontal disease may have significant effects in public health. Strategies to prevent this disease should consider the role of oral health care products that may be utilized by patients at the individual level. In this sense, the development of new pharmacological products focused on the modulation of periodontal infection and inflammation should be envisaged as an interesting alternative for the prevention of periodontal disease. The present review analyses the role of pharmacological agents, used in dentifrices, that may have a positive effect in the control of gingivitis and periodontal disease.

Key words:
Prevention
dentifrice
triclosan
periodontal disease
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Referencias Bibliográficas
[1.]
R.C. Page, S. Offenbacher, H.E. Schroeder, G.J. Seymour, K.S. Kornman.
Advances in the pathogenesis of periodontitis: summary of developments, clinical implications and future directions.
Periodontology 2000, 14 (1997), pp. 216-248
[2.]
D. Kinane.
Causation and pathogenesis of periodontal disease.
Periodontology 2000, 25 (2001), pp. 8-20
[3.]
P.M. Bartold, A.S. Narayanan.
Molecular and cell biology of healthy and diseased periodontal tissues.
Periodontology 2000, 40 (2006), pp. 29-49
[4.]
V.-J. Uitto, C.M. Overall, C.A. McCulloch.
Proteolytic host cell enzymes in gingival crevice fluid.
Periodontology 2000, 31 (2003), pp. 77-104
[5.]
P.C. Smith, V. Muñoz, L. Collados, A.D. Oyarzún.
In situ detection of matrix metalloproteinase- 9 (MMP-9) in gingival epithelium in human periodontal disease.
J Periodont Res, 39 (2004), pp. 87-92
[6.]
P.C. Smith, J.F. Santibañez, J.P. Morales, J. Martínez.
Epidermal growth factor stimulates urokinase-type plasminogen activator expression in human gingival fibroblasts Possible modulation by genistein and curcumin.
J Periodont Res, 39 (2004), pp. 380-387
[7.]
P. Pozo, M.A. Valenzuela, C. Melej, M. Zaldivar, J. Puente, B. Martínez, J. Gamonal.
Longitudinal analysis of metalloproteinases, tissue inhibitors of metalloproteinases and clinical parameters in gingival crevicular fluid from periodontitis-affected patients.
J Periodontal Res, 40 (2005), pp. 199-207
[8.]
N. Silva, N. Dutzan, M. Hernández, A. Dezerega, O. Rivera, J.C. Aguillon, O. Aravena, P. Lastres, P. Pozo, R. Vernal, J. Gamonal.
Characterization of progressive periodontal lesions in chronic periodontitis patients: levels of chemokines, cytokines, matrix metalloproteinase-13, periodontal pathogens and inflammatory cells.
J Clin Periodontol, 35 (2008), pp. 206-214
[9.]
B.L. Mealey, L.F. Rose, Diabetes mellitus.
inflammatory periodontal diseases.
Curr Opin Endocrinol Diabetes Obes, 15 (2008), pp. 135-141
[10.]
S. Awano, T. Ansai, Y. Takata, I. Soh, S. Akifusa, T. Hamasaki, A. Yoshida, K. Sonoki, K. Fujisawa, T. Takehara.
Oral health and mortality risk from pneumonia in the elderly.
J Dent Res, 87 (2008), pp. 334-339
[11.]
M.S. Tonetti, F. D’Aiuto, L. Nibali, A. Donald, C. Storry, M. Parkar, J. Suvan, A.D. Hingorani, P. Vallance, J. Deanfield.
Treatment of periodontitis and endothelial function.
N Engl J Med, 356 (2007), pp. 911-920
[12.]
M. Ruma, K. Boggess, K. Moss, H. Jared, A. Murtha, J. Beck, S. Offenbacher.
Maternal periodontal disease, systemic inflammation, and risk for preeclampsia.
Am J Obstet Gynecol, 198 (2008), pp. 389
[13.]
H. Yoshie, T. Kobayashi, H. Tai, J.C. Galicia.
The role of genetic polymorphisms in periodontitis.
Periodontology 2000, 43 (2007), pp. 102-132
[14.]
M.I. Ryder.
The influence of smoking on host responses in periodontal infections.
Periodontology, 43 (2000), pp. 267-277
[15.]
F. Nishimura, Y. Iwamoto, Y. Soga.
The periodontal host response with diabetes.
Periodontology, 43 (2000), pp. 245-253
[16.]
R.M. Davies.
Toothpaste in the control of plaque/gingivitis and periodontitis.
Periodontol 2000, 48 (2008), pp. 23-30
[17.]
A. Sheiham, G.S. Netuvile.
Periodontal diseases in Europe.
Periodontology 2000, 29 (2002), pp. 104-121
[18.]
J. Gamonal, N.J. López, W. Aranda.
Periodontal conditions and treatment needs, by CPITN, in the 35-44 and 65-74 year-old population in Santiago, Chile.
Int Dent J, 48 (1998), pp. 96-103
[19.]
P. Gjermo, C.K. Rösing, C. Susin, R. Opperman.
Periodontal diseases in Central and South America.
Periodontol 2000, 29 (2002), pp. 70-78
[20.]
B. Bakdash.
Current patterns of oral higiene product use and practices.
Periodontol 2000, 8 (1995), pp. 11-14
[21.]
A.J. Morris, J. Steele, D.A. White.
The oral cleanliness and periodontal health of UK adults in 1998.
Br Dent J, 191 (2001), pp. 186-192
[22.]
P. Garmyn, D. van Steenberghe, M. Quirynen.
Efficacy of plaque control in the maintenance of gingival health: plaque control in primary and secondary prevention.
Proceedings of the european workshop on mechanical plaque control,
[23.]
D. Bratthall, G. Hansel-Petersson, H. Sundberg.
Reasons for the caries decline: what do the experts think?.
Eur J Oral Sci, 104 (1996), pp. 416-422
[24.]
N. Tinanoff.
Review on the antimicrobial action of stannous fluoride.
J Clin Dent, 2 (1990), pp. 22-27
[25.]
S. Paraskevas, G.A. van der Weijden.
A review of stannous fluoride on gingivitis.
J Clin Periodontol, 33 (2006), pp. 1-13
[26.]
M. Addy, J.M. Moran.
Clinical indications for the use of chemical adjuncts to plaque control.
Periodontology 2000, 15 (1997), pp. 40-51
[27.]
C.G. Jones.
Chlorhexidine: is still the gold standard?.
Periodontol 2000, 15 (1997), pp. 55-62
[28.]
M. Sanz, N. Vallcorba, S. Fabregues, I. Muller, F. Herkstroter.
The effect of a dentifrice containing chlorhexidine and zinc on plaque, gingivitis, calculus and tooth stain.
J Clin Periodontol, 21 (2004), pp. 431-437
[29.]
R. Yates, S. Jenkins, R. Newcombe, W. Wade, J. Moran, M. Addy.
A 6-month home usage trial of a 1% chlorhexidine toothpaste (1) Effects on plaque, gingivitis, calculus and toothstaining.
J Clin Periodontol, 20 (1993), pp. 130-138
[30.]
C.A. Saxton.
Maintenance of gingival health by a dentifrice containing zinc citrate and triclosan.
J Dent Res, 68 (1989), pp. 1724-1730
[31.]
A. Gaffar, D. Scherl, J. Afflitto, E.J. Coleman.
The effect of triclosan on mediators of gingival inflammation.
J Clin Periodontol, 22 (1995), pp. 480-484
[32.]
T.E. Bolden, J.J. Zambon, J. Sowinski, F. Ayad, J.J. McCool, A.R. Volpe, W. De Vizio.
The clinical effect of a dentifrice containing triclosan and a copolymer in a sodium fluoride/silica base on plaque formation and gingivitis: a six-month clinical study.
J Clin Dent, 3 (1992), pp. 125-131
[33.]
A.B. Cubells, L.B. Dalmau, M.E. Petrone, P. Chaknis, A.R. Volpe.
The effect of a Triclosan/copolymer fluoride dentifrice on plaque formation and gingivitis: a six-month clinical study.
J Clin Dent, 2 (1991), pp. 63-69
[34.]
U. Kanchanakamol, R. Umpriwan, N. Jotikasthira, W. Sholitkul, T. Chat Uthai.
Reduction of plaque formation and gingivitis by a dentifrice containing triclosan and copolymer.
J Periodontol, 66 (1995), pp. 109-112
[35.]
J. Lindhe, B. Rosling, S.S. Socransky, A.R. Volpe.
The effect of a triclosan-containing dentifrice on established plaque and gingivitis.
J Clin Periodontol, 20 (1993), pp. 327-334
[36.]
P. Ramberg, Y. Furuichi, D. Sherl, A.R. Volpe, N. Nabi, A. Gaffar, J. Lindhe.
The effect of triclosan on developing gingivitis.
J Clin Periodontol, 22 (1995), pp. 63-70
[37.]
S. Renvert, D. Birkhed.
Comparison between 3 triclosan dentifrices on plaque, gingivitis and salivary microflora.
J Clin Periodontol, 22 (1995), pp. 63-70
[38.]
J.C. Gunsolley.
A meta-analysis of six-month studies of anti-plaque and anti-gingivitis agents.
J Am Dent Assoc, 137 (2006), pp. 1649-1650
[39.]
K.P.K.J. Hioe, G.A. van der Weijden.
The effectiveness of self performed mechanical plaque control with triclosan containing dentifrices.
Int J Dent Hyg, 3 (2005), pp. 192-204
[40.]
R.P. Ellwood, H.V. Worthington, A.S. Blinkhorn, A.R. Volpe, R.M. Davies.
Effect of triclosan/copolimer dentifrice on the incidente of periodontal attachment loss in adolescents.
J Clin Periodontol, 25 (1998), pp. 363-367
[41.]
B. Rosling, B. Wannfors, A.R. Volpe, Y. Furuichi, P. Ramberg, J. Lindhe.
The use of a triclosan/copolymer dentifrice may retard the progression of periodontitis.
J Clin Periodontol, 24 (1997), pp. 873-880
[42.]
M.P. Cullinan, B. Westerman, S.M. Hamlet, M.J. Faddy, G.J. Seymour.
The effect of a triclosan containing dentifrice on the progression of periodontal disease in an adult population.
J Clin Periodontol, 30 (2003), pp. 414-419
[43.]
V. Kerdvongbundit, U.M.E. Wikesjo.
Effect of triclosan on healing following non-surgical periodontal therapy in smokers.
J Clin Periodontol, 30 (2003), pp. 1024-1030
[44.]
K.W. Stephen, C.A. Saxton, C.L. Jones, J.A. Ritchie, T. Morrison.
Control of gingivitis and calculus by a dentifrice containing a zinc salt and triclosan.
J Periodontol, 61 (1990), pp. 674-679
[45.]
J.E. Ellingsen, G. Rölla.
Dental plaque inhibition by a combination of triclosan and polydimethylsiloxane (silicone oil).
Scand J Dent Res, 102 (1994), pp. 26-29
[46.]
R. Niederman.
Triclosan-containing toothpastes reduce plaque gingivitis.
Evid Based Dent, 6 (2005), pp. 33
[47.]
H.P. Müller, K.M. Barrieshi-Nusair, E. Könönen, M. Yang.
Effect of triclosan/copolymer-containing toothpaste on the association between plaque and gingival bleeding: a randomized controlled clinical trial.
J Clin Periodontol, 33 (2003), pp. 811-818
[48.]
P. Barkvoll, G. Rölla.
Triclosan protects the skin against dermatitis caused by sodium lauryl sulphate exposure.
J Clin Periodontol, 21 (1994), pp. 717-719
[49.]
T. Modéer, A. Bengtsson, G. Rölla.
Triclosan reduces prostaglandin biosynthesis in human gingival fibroblasts challenged with interleukin-1 in vitro.
J Clin Periodontol, 23 (1996), pp. 927-933
[50.]
M. Mustafa, B. Wondimu, T. Yucel-Lindberg, T. Kats A-Hallström, A.S. Jonsson, T. Modéer.
Triclosan reduces microsomal prostaglandin E synthase-1 expression in human gingival fibroblasts.
J Clin Periodontol, 32 (2005), pp. 6-11
[51.]
A. Skaare, G. Eide, B. Herlofson, P. Barkvoll, G. Rölla.
The effect of toothpaste containing triclosan on oral mucosal desquamation.
J Clin Periodontol, 23 (1996), pp. 1100-1110
[52.]
Y. Furuichi, B. Rosling, A.R. Volpe, J. Lindhe.
The effect of a triclosan/copolymer dentifrice on healing after non-surgical treatment of recurrent periodontitis.
J Clin Periodontol, 26 (1999), pp. 63-66
[53.]
Arancibia R, Cáceres M, Martínez J, Smith PC. Triclosan inhibits TNF-α-stimulated urokinase production in human gingival fibroblasts. Aceptado para su publicación en Journal of Periodontal Research.
[54.]
J.A. Aguirre Ghiso, D.F. Alonso, E.F. Faro, D.E. Gomez, E. Bal de Kier Joffe.
Deregulation of the signaling pathways controlling urokinase production Its relationship with the invasive phenotype.
Eur J Biochem, 263 (1999), pp. 295-304
[55.]
P.C. Smith, J. Martínez.
Differential uPA expression by TGF-β1 in human gingival fibroblasts.
J Dent Res, 85 (2006), pp. 150-155
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