Información del artículo
Resumen
La enfermedad periodontal requiere de un hospedero susceptible para su desarrollo y progresión. Dentro de las características del hospedero se encuentra la respuesta de células T reguladoras, que proveen de tolerancia frente antígenos propios, pero a la vez, participa durante las enfermedades infecciosas y tumorales como mecanismos de evasión de la respuesta inmune efectora. En infecciones virales, parasitarias y bacterianas se ha visto que los linfocitos T reguladores (Tregs) generan la persistencia de la infección en el tiempo y son responsables de muchos de los cambios patológicos de estas. Investigaciones recientes en enfermedad periodontal indican que se encuentran presentes en gran cantidad, pero su rol en la patogénesis de la enfermedad se encuentra en estudio. Esta revisión muestra los resultados de los estudios publicados en el área de periodoncia, que señalan una posible asociación entre los Tregs y la infección periodontal.
Palabras clave:
L Linfocitos T reguladores
periodontitis
tolerancia
Abstract
Periodontal disease requires a susceptible host for it's development and progression. One of the characteristics of the host is the regulatory response that give tolerance against own antigens, but at the same time, is used during infectious and tumoral diseases as a mechanism of evasion of the immune response. In viral, parasitic and bacterial infections regulatory T cells (Tregs) cause persistence of the infection, and they are responsible of many of the pathologic changes. Recent investigations in periodontal disease show that Tregs are present in a great quantity, but it's role is in current study. This review shows the results of published studies in periodontics that lead to a possible association between Tregs and periodontal infection.
Key words:
Regulatory T cells
periodontal disease
tolerance
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