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Inicio Revista Colombiana de Cardiología Los niveles de ferritina y los marcadores de riesgo cardiovascular se correlacio...
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Vol. 19. Núm. 1.
Páginas 4-10 (enero - febrero 2012)
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Vol. 19. Núm. 1.
Páginas 4-10 (enero - febrero 2012)
Open Access
Los niveles de ferritina y los marcadores de riesgo cardiovascular se correlacionan con mayor tiempo sedentario auto-reportado en hombres aparentemente sanos
Ferritin levels and cardiovascular risk markers correlate with higher self-reported sedentary time in apparently healthy men
Visitas
6321
Milton F. Suárez1,
Autor para correspondencia
fabian.suarezuv@gmail.com

Correspondencia: Universidad del Valle. Calle 4B No. 36-00 Sede San Fernando. Departamento de Ciencias Fisiológicas. Edificio 116. Santiago de Cali, Valle del Cauca, Colombia. Teléfono: (+572) 5 18 56 03.
, Alejandra Arbeláez1, Mildrey Mosquera1, Robinson Ramírez-Vélez1,
Autor para correspondencia
robin640@hotmail.com

Correspondencia: Universidad del Valle. Calle 4B No. 36-00 Sede San Fernando. Departamento de Ciencias Fisiológicas. Edificio 116. Santiago de Cali, Valle del Cauca, Colombia. Teléfono: (+572) 5 18 56 03.
, Ana Cecilia Aguilar de Plata1
1 Grupo de Nutrición. Departamento de Ciencias Fisiológicas. Escuela de Ciencias Básicas. Facultad de Salud. Universidad del Valle. Cali, Colombia. Calle 4B No. 36-00, Sede San Fernando
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Información del artículo
Objetivo

evaluar la correlación entre las concentraciones séricas de ferritina y los marcadores de riesgo cardiovascular con el tiempo de actividad física y sedentarismo auto-reportados en hombres aparentemente sanos.

Métodos

se incluyeron 69 hombres pertenecientes a tres empresas de servicio privado y público del área metropolitana de Cali, Colombia, con edades entre 25 y 64 años. Se aplicó la versión corta del International Physical Activity Questionnaire (IPAQ) y se agruparon cuatro categorías de actividad física:

  • 1.

    Minutos actividad física intensa (AFI)/semana.

  • 2.

    Minutos actividad física moderada (AFM)/semana.

  • 3.

    Minutos caminata/semana.

  • 4.

    Minutos sentado/día.

    Los marcadores de riesgo cardiovascular se definieron con base en los criterios del ATP-III y la Federación Internacional de Diabetes.

Resultados

se encontraron correlaciones positivas en los sujetos que auto-reportaban mayor tiempo en actividades sedentarias según la categoría del IPAQ (minutos promedio sentado/día) en los indicadores antropométricos: porcentaje de grasa corporal (rho=0,249, p<0,05), índice de masa (rho=0,268, p<0,05) y circunferencia de cintura (rho=0,266, p<0,05). Este mismo comportamiento se observó en las variables bioquímicas: ferritina (rho=0,247, p<0,05), triglicéridos (rho=0,258, p<0,05), insulina (rho=0,284, p<0,05) e índice HOMA (rho=0,261). Asimismo, se evidenciaron menores niveles de c-HDL a menores niveles de actividad física (rho=-0,279; p<0,05).

Conclusiones

el tiempo sedentario (minutos sentado/semana) reportado por los sujetos, se correlacionó de manera positiva con los niveles de ferritina así como con la resistencia a la insulina y los marcadores de riesgo cardiovascular. Los depósitos de hierro corporales estimados como ferritina sérica, al relacionarse con parámetros de sedentarismo, se comportan como un potencial marcador de riesgo cardiovascular.

Palabras clave:
actividad física
sedentarismo
riesgo cardiovascular
hombres
Colombia
Objective

to evaluate the correlation between serum ferritin and cardiovascular risk markers with the time of self-reported physical activity and sedentary life style in apparently healthy men.

Methods

we included 69 men from three private and public companies in the metropolitan area of Cali, Colombia, aged between 25 and 64. The short version of the International Physical Activity Questionnaire (IPAQ) was applied, and were grouped in four categories of physical activity:

  • 1.

    Minutes of intense physical activity (IFA)/week.

  • 2.

    Minutes of moderate physical activity (MFA)/week.

  • 3.

    Minutes of walk/week.

  • 4.

    Minutes of sitting/day.

    Cardiovascular risk markers were defined based on the criteria of the ATP-III and the International Diabetes Federation.

Results

positive correlations were found in subjects who self-reported more time in sedentary activities according to the IPAQ category (average minutes sitting/day) in anthropometric indicators: percentage of body fat (rho = 0.249, p <0.05), mass index (rho = 0.268, p <0.05) and waist circumference (rho = 0.266, p <0.05). This same behavior was observed in biochemical variables: ferritin (rho = 0.247, p <0.05), triglycerides (rho = 0.258, p <0.05), insulin (rho = 0.284, p <0.05) and HOMA index (rho = 0.261). Also, lower levels of HDL-C were evidenced with lower levels of physical activity (rho =- 0.279, P <0.05).

Conclusions

sedentary time (minutes sitting/week) reported by the subjects correlated positively with ferritin levels as well as with insulin resistance and cardiovascular risk markers. The body iron deposits estimated as serum ferritin, when related to sedentary lifestyle parameters, behave as a potential marker of cardiovascular risk.

Keywords:
physical activity
sedentary lifestyle
cardiovascular risk
men
Colombia
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Bibliografía
[1.]
J.M. Fernández-Real, E. Esteve, W. Ricart.
Hierro, resistencia a la insulina y riesgo cardiovascular.
Clin Invest Arterioscl, 16 (2004), pp. 114-121
[2.]
J.T. Salonen, T.-P. Tuomainen, K. Nyyssönen, H.-M. Lakka, K. Punnonen.
Relation between iron stores and non-insulin-dependent diabetes in men: case-control study.
BMJ, 317 (1999), pp. 727-730
[3.]
A. Oshaug, K.H. Bugge, C.H. Bjønnes, B. Borch-Iohnsen, I.L. Neslein.
Prevalence of body iron excess in the metabolic syndrome.
Diabetes Care, 28 (2005), pp. 2061-2063
[4.]
E.S. Ford, M.E. Cogswell.
Diabetes and serum ferritin concentration among U.S. adults.
Diabetes Care, 22 (1999), pp. 1978-1983
[5.]
D.J. Fleming, P.F. Jacques, K.L. Tucker, J.M. Massaro, R.B. D’Agostino, P.W.F. Wilson, et al.
Iron status of the free-living, elderly Framingham Heart Study cohort: an ironreplete population with a high prevalence of elevated iron stores.
Am J Clin Nutr, 73 (2001), pp. 638-646
[6.]
Y. Ikeda, T. Suehiro, S. Yamanaka, Y. Kumon, H. Takata, S. Inada, et al.
Association between serum ferritin and circulating oxidized low-density lipoprotein levels in patients with type 2 diabetes.
Endocr J, 53 (2006), pp. 665-670
[7.]
N. Milman, M. Kirchhoff.
Relationship between serum ferritin and risk factors for ischaemic heart disease in 2235 danes aged 30-60 years.
J Intern Med, 245 (1999), pp. 423-433
[8.]
P. Galan, N. Noisette, C. Estaquio, S. Czernichow, L. Mennen, J.C. Renversez, et al.
Serum ferritin, cardiovascular risk factors and ischaemic heart diseases: A prospective analysis in the SU.VI.MAX (Supplementation en Vitamines et mineraux AntioXydants) cohort.
Public Health Nutr, 9 (2006), pp. 70-74
[9.]
P. Dongiovanni, L. Valenti, A. Ludovica Fracanzani, S. Gatti, G. Cairo, S. Fargion.
Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liver.
Am J Pathol, 172 (2008), pp. 738-747
[10.]
J. Chen, R.P. Wildman, L.L. Hamm, P. Muntner, K. Reynolds, P.K. Whelton, et al.
Association between inflammation and insulin resistance in U.S. nondiabetic adults: results from the Third National Health and Nutrition Examination Survey Diabetes Care.
, 27 (2004), pp. 2960-2965
[11.]
B. Gelaye, L. Revilla, T. Lopez, L. Suárez, S.E. Sánchez, et al.
Association between insulin resistance and C-reactive protein among Peruvian adults.
Diabetol Metab Syndr, 18 (2010), pp. 30
[12.]
T.A. Lakka, K. Nyyssonen, J.T. Salonen.
Higher levels of conditioning leisure time physical activity are associated with reduced levels of stored iron in Finnish men.
Am J Epidemiol, 140 (1994), pp. 148-160
[13.]
J.M. Liu, S.E. Hankinson, M.J. Stampfer, N. Rifai, W.C. Willett, J. Ma.
Body iron stores and their determinants in healthy postmenopausal US women.
Am J Clin Nutr, 78 (2003), pp. 1160-1167
[14.]
B.J. Naimark, A.E. Ready, J.A. Sawatzky.
et al.
Serum ferritin and heart disease: The effect of moderate exercise on stored iron levels in postmenopausal women. Can J Cardiol, 12 (1996), pp. 1253-1317
[15.]
CDC. General physical activities defined by level of intensity. 2006. [Consultado: enero 2 de 2010]. Disponible en: http://www.cdc.gov/physicalactivity/everyone/health/index.html#ReduceDiabetes.
[16.]
H.G. Peach, N.E. Barnett.
Relationship between serum ferritin concentration and established risk factors among men in a population with a high mortality from cardiovascular disease.
Nutrition & Dietetics, 59 (2002), pp. 97-112
[17.]
E. Bergstrom, O. Hernell, L.A. Persson.
Endurance running performance in relation to cardiovascular risk indicators in adolescents.
Int J Sports Med, 18 (1997), pp. 300-307
[18.]
M. Furqan, M. Nafees, T. Jilani, M. Hijazi.
Relationship between physical activity and serum ferritin levels.
Annals of Abbasi Shaheed Hospital and Karachi Medical and Dental College, 7 (2002), pp. 306-309
[19.]
M.A. Delavar, L.M. Sann, S.T. Hassan, K.G. Linn, P. Hannachi.
Physical activity and the metabolic syndrome in middle aged women, Babol, Mazandaran province.
Iran. EJSR, 22 (2008), pp. 411-421
[20.]
R.R. Dalacorte, C.L. Reichert, J.L. Vieira.
Metabolic syndrome and physical activity in outhern Brazilian community-dwelling elders: a population-based, cross-sectional study.
BMC Public Health, 21 (2009), pp. 9-25
[21.]
Executive Summary of the Third Report of National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel.
III)., JAMA, 285 (2001), pp. 2486-2497
[22.]
D.J. Freeman, J. Norrie, M.J. Caslake, A. Gaw, I. Ford, G.D. Lowe, et al.
C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study.
Diabetes, 51 (2002), pp. 1596-1600
[23.]
J.M. Fernández-Real, W. Ricart-Engel, E. Arroyo, R. Balançá, R. Casamitjana-Abella, D. Cabrero, et al.
Serum ferritin as a component of the insulin resistance syndrome.
Diabetes Care, 21 (1998), pp. 62-68
[24.]
International Diabetes Federation, Prevalence [sede Web]. Bruselas: International Diabetes Federation; 2005 [citado 2008 11 Dic]. Disponible en: http://www.eatlas.idf.org/Prevalence/index.cfm.
[25.]
M. Pérez, J.P. Casas, L.A. Cubillos-Garzón, N.C. Serrano, F. Silva, C.A. Morillo, et al.
Using waist circumference as a screening tool to identify Colombian subjects at cardiovascular risk.
Eur J Cardiovasc Prev Rehabil, 10 (2003), pp. 328-335
[26.]
C.A. López, R. Ramírez-Vélez, C.E.G. Gallardo, L.C. Marmolejo.
Características morfofuncionales de individuos físicamente activos.
Iatreia, 21 (2008), pp. 121-128
[27.]
K. Kishi, K. Ochiai, Y. Ohta.
Highly sensitive cholesterol assay with enzymatic cycling applied to measurement of remnant lipoprotein-cholesterol in serum.
Clin Chem, 48 (2002), pp. 737-741
[28.]
W.T. Friedewald, R.I. Levy, D.S. Fredrickson.
Estimation of the concentration of LDL in plasma, without use of the preparative ultracentrifuge.
Clin Chem, 18 (1972), pp. 499-502
[29.]
Grassi J, Pradelles P. Compounds labelled by the acetylcholinesterase of Electrophorus Electricus. Its preparation process and its use as a tracer or marquer in enzymoimmunological determinations. United States patent, N° 1,047,330. September 10, 1991.
[30.]
T.P. Tuomainen, K. Nyysönen, R. Salonen, A. Tervahauta, H. Korpela, T. Lakka.
Body iron stores are associated with serum insulin and blood glucose concentrations.
Diabetes Care, 20 (1997), pp. 426-428
[31.]
J.M. Fernández-Real, W. Ricart, E. Arroyo, R. Balança, R. Casamitjana, D. Cabrero.
Serum ferritin as a component of the insulin resistance syndrome.
Diabetes Care, 21 (1998), pp. 62-68
[32.]
C. Hernández, A. Lecube, A. Carrear, R. Simó.
Soluble transferrin receptors and ferritin in type 2 diabetic patients.
[33.]
A. Esteghamati, O. Khalilzadeh, A. Rashidi, A. Meysamie, M. Haghazali, F. Asgari, M. Abbasi, et al.
Association between physical activity and insulin resistance in Iranian adults: National Surveillance of Risk Factors of Non-Communicable Diseases (SuRFNCD-2007).
Prev Med, 49 (2009), pp. 402-406
[34.]
K. Suija, U. Pechter, J. Maaroos, R. Kalda, A. Rätsep, M. Oona, H.I. Maaroos.
Physical activity of Estonian family doctors and their counselling for a healthy lifestyle: a crosssectional study.
BMC Fam Pract, 11 (2010), pp. 48
[35.]
J.P. McClung, J.P. Karl, S.J. Cable, K.W. Williams, B.C. Nindl, A.J. Young, et al.
Randomized, double-blind, placebo-controlled trial of iron supplementation in female soldiers during military training: effects on iron status, physical performance, and mood.
Am J Clin Nutr, 90 (2009), pp. 124-131
[36.]
T.D. Le, S. Bae, C. Ed Hsu, K.P. Singh, S.N. Blair, N. Shang.
Effects of cardiorespiratory fitness on serum ferritin concentration and incidence of type 2 diabetes: Evidence from the Aerobics Center Longitudinal Study (ACLS).
Rev Diabet Stud, 5 (2008), pp. 245-252
[37.]
J.T. Salonen, K. Nyyssönen, H. Korpela, J. Tuomilehto, R. Seppänen, R. Salonen.
High stored iron levels are associated with excess risk of myocardial infarction in eastern Finnish men.
Circulation, 86 (1992), pp. 803-811
[38.]
C. Kasapis, P.D. Thompson.
The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review.
J Am Coll Cardiol, 45 (2005), pp. 1563-1569
[39.]
E.S. Rawson, P.S. Freedson, S.K. Osganian, C.E. Matthews, G. Reed, I.S. Ockene.
Body mass index, but not physical activity, is associated with C-reactive protein.
Med Sci Sports Exerc, 35 (2003), pp. 1160-1166
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