array:23 [ "pii" => "S2444440524000475" "issn" => "24444405" "doi" => "10.1016/j.rcreue.2023.12.001" "estado" => "S300" "fechaPublicacion" => "2024-04-01" "aid" => "2101" "copyright" => "Asociación Colombiana de Reumatología" "copyrightAnyo" => "2024" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Colomb Reumatol. 2024;31 Supl 1:S132-S138" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:18 [ "pii" => "S2444440524000487" "issn" => "24444405" "doi" => "10.1016/j.rcreue.2023.12.002" "estado" => "S300" "fechaPublicacion" => "2024-04-01" "aid" => "2103" "copyright" => "Asociación Colombiana de Reumatología" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Colomb Reumatol. 2024;31 Supl 1:S139-S153" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Special Article</span>" "titulo" => "Interstitial lung disease in autoimmune diseases" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "S139" "paginaFinal" => "S153" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad pulmonar intersticial en las enfermedades autoinmunes" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0015" "etiqueta" => "Fig. 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 995 "Ancho" => 1508 "Tamanyo" => 177145 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">NSIP: idiopathic versus connective tissue-associated pulmonary disease. (A and B) Axial HRCT through the mid and lower lungs in a patient with idiopathic NSIP shows basal predominant ground-glass opacity, fine reticulation, and traction bronchiectasis. Note presence of subpleural sparing (arrowheads). (C and D) Axial HRCT through the mid and lower lungs in a patient with scleroderma shows findings similar to the patient with idiopathic NSIP, including basal predominant ground-glass opacity, reticulation, and traction bronchiectasis. A clue to the presence of scleroderma is the dilated esophagus (arrow).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Vivek Nagaraja, Isabel Mira-Avendano, Alejandro Diaz-Arumir, Michael Gotway, Ana C. Zamora" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Vivek" "apellidos" => "Nagaraja" ] 1 => array:2 [ "nombre" => "Isabel" "apellidos" => "Mira-Avendano" ] 2 => array:2 [ "nombre" => "Alejandro" "apellidos" => "Diaz-Arumir" ] 3 => array:2 [ "nombre" => "Michael" "apellidos" => "Gotway" ] 4 => array:2 [ "nombre" => "Ana C." "apellidos" => "Zamora" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440524000487?idApp=UINPBA00004N" "url" => "/24444405/00000031000000S1/v1_202405240522/S2444440524000487/v1_202405240522/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S2444440524000463" "issn" => "24444405" "doi" => "10.1016/j.rcreue.2023.10.007" "estado" => "S300" "fechaPublicacion" => "2024-04-01" "aid" => "2090" "copyright" => "Asociación Colombiana de Reumatología" "documento" => "article" "crossmark" => 1 "subdocumento" => "rev" "cita" => "Rev Colomb Reumatol. 2024;31 Supl 1:S123-S131" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>" "titulo" => "Interstitial lung disease in primary Sjögren's syndrome" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "S123" "paginaFinal" => "S131" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfermedad pulmonar intersticial en el síndrome de Sjögren primario" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1510 "Ancho" => 2007 "Tamanyo" => 377930 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Patterns of high-resolution computed tomography of the chest in interstitial lung disease in Sjögren Syndrome. (A) Non-specific interstitial pneumonia, (B) usual interstitial pneumonia, (C) lymphoid interstitial pneumonia, and (D) combined pattern of non-specific interstitial pneumonia associated with organizing pneumonia.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Santiago Auteri, Anastasia Secco" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Santiago" "apellidos" => "Auteri" ] 1 => array:2 [ "nombre" => "Anastasia" "apellidos" => "Secco" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S2444440524000463?idApp=UINPBA00004N" "url" => "/24444405/00000031000000S1/v1_202405240522/S2444440524000463/v1_202405240522/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Special article</span>" "titulo" => "Genetics of autoimmune-associated interstitial lung diseases: A focus on rheumatoid arthritis" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "S132" "paginaFinal" => "S138" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Philippe Dieudé" "autores" => array:1 [ 0 => array:4 [ "nombre" => "Philippe" "apellidos" => "Dieudé" "email" => array:1 [ 0 => "philippe.dieude@aphp.fr" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Université de Paris, INSERM UMR 1152, Paris, France" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Rheumatology Service, Hôpital Bichat-Claude Bernard, AP-HP, Paris, France" "etiqueta" => "b" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Genética de las enfermedades pulmonares intersticiales autoinmunes asociadas: un enfoque sobre la artritis reumatoide" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2223 "Ancho" => 1675 "Tamanyo" => 196903 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Similarities between idiopathic pulmonary fibrosis and rheumatoid arthritis associated interstitial lung disease. RA-ILD: rheumatoid arthritis associated interstitial lung disease; IPF: idiopathic pulmonary fibrosis.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Epidemiology</span><p id="par0005" class="elsevierStylePara elsevierViewall">Rheumatoid arthritis (RA) is a destructive, systemic inflammatory and autoimmune disorder that affects up to 1% of the general adult population worldwide. Extra-articular disease occurs in nearly 50% of all patients with RA the lung being frequently involved.<a class="elsevierStyleCrossRef" href="#bib0280"><span class="elsevierStyleSup">1</span></a> Both exact prevalence and incidence of interstitial lung disease (ILD) in rheumatoid arthritis (RA) are unknown. The reported prevalence of ILD in patients with RA varies widely depending on the population studied, the method of detection and the criteria used to define ILD. Indeed, the frequency of RA-ILD disease has long been underestimated as it can remain asymptomatic for a long time and as low-sensitivity detection tools such as chest radiography still frequently used. In addition, (i) data on the natural history of RA-ILD are limited, with no currently established guidelines for screening<a class="elsevierStyleCrossRef" href="#bib0285"><span class="elsevierStyleSup">2</span></a> and (ii) several parameters that could impact the risk of occurrence of RA-ILD, such as age at RA onset, RA duration, RA disease activity, occupational exposure or smoking status vary from one study to another, making it difficult to interpret the epidemiological data of RA-ILD.</p><p id="par0010" class="elsevierStylePara elsevierViewall">If the reported incidence of ILD among patients with RA varies considerably, it should be noted that while the incidence of extra-articular manifestations of RA appears to be decreasing, probably due to the recommendations for the management of RA including early detection, tight control and treat-to-target strategy, the estimates of incidence of RA-ILD appears to be stable or even increasing in the largest studies.<a class="elsevierStyleCrossRefs" href="#bib0290"><span class="elsevierStyleSup">3–6</span></a> In line with this, a recent analysis of a US health insurance database found an incidence of RA-ILD of 2.7 cases per 100<span class="elsevierStyleHsp" style=""></span>000 people in 2007 increasing to 3.8 in 2014.<a class="elsevierStyleCrossRef" href="#bib0310"><span class="elsevierStyleSup">7</span></a> This apparent increase in the incidence of RA-ILD probably illustrates the more frequent use of more sensitive detection tools such as high-resolution chest computed tomography (HRCT) which is considered as the gold standard for radiologic assessment of ILD.<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">8</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">A recent meta-analysis including 18<span class="elsevierStyleHsp" style=""></span>884 patients with RA found a pooled prevalence of clinically significant (<span class="elsevierStyleItalic">i.e.</span> symptomatic) ILD of 11%, 95%CI (7–15%).<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">9</span></a> A systematic assessment of ILD by HRCT has contributed to an increase in the prevalence of RA-ILD. Indeed, it is estimated that asymptomatic ILD may complicate up to 41% of patients with RA.<a class="elsevierStyleCrossRef" href="#bib0325"><span class="elsevierStyleSup">10</span></a> However, more recent large prospective or cross-sectional studies using HRCT and/or pulmonary function tests as a screening tool suggest that the prevalence of asymptomatic RA-ILD is around 20%.<a class="elsevierStyleCrossRefs" href="#bib0330"><span class="elsevierStyleSup">11–13</span></a> This prevalence is likely to be underestimated, as in an international survey of 354 rheumatologists conducted in 2019, 44% did not consider screening for RA-ILD in patients with risk factors.<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">14</span></a></p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Known genetic architecture of RA-ILD</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">RA-ILD is a complex disease</span><p id="par0020" class="elsevierStylePara elsevierViewall">RA is a complex disease implicating environmental, genetic, and stochastic factors. However, the weight of genetics is underlined by family studies, estimating that more than 50% of the variance in disease risk is explained by genetic factors.<a class="elsevierStyleCrossRef" href="#bib0350"><span class="elsevierStyleSup">15</span></a> Although the physiopathology of RA-ILD is poorly understood, this severe extraarticular manifestation of RA should be considered as a multifactorial disease involving both genetic and environmental factors.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Similarities between RA-ILD and idiopathic pulmonary fibrosis</span><p id="par0025" class="elsevierStylePara elsevierViewall">Usual interstitial pneumonia (UIP) is a pattern of pulmonary fibrosis detected radiologically by HRCT or pathologically by lung biopsy.<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">16</span></a> When UIP occurs in patients with an unknown cause (<span class="elsevierStyleItalic">i.e.</span> idiopathic UIP), it is classified as idiopathic pulmonary fibrosis (IPF), which is a chronic, progressive, and fatal disease of the lungs. When UIP occurs in patients with RA, it is known as RA-UIP, a specific subtype of RA-ILD. Compared with other autoimmune diseases, the specificity of RA-ILD lies in the relatively high proportion of patients with a HRCT UIP pattern. A recent meta-analysis including 4987 patients with RA-ILD found a pooled prevalence of UIP of 46%, whereas the other autoimmune diseases where frequently associated with a pattern of non-specific interstitial pneumonia (NSIP).<a class="elsevierStyleCrossRef" href="#bib0320"><span class="elsevierStyleSup">9</span></a> RA-UIP and IPF share several features such as older age at onset (around the 6th and 7th decade, respectively), a male sex predominance, a very severe prognosis and indistinguishable patterns of ILD on HRCT (<span class="elsevierStyleItalic">e.g.</span> UIP).<a class="elsevierStyleCrossRefs" href="#bib0360"><span class="elsevierStyleSup">17–22</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">RA is an autoimmune disease characterized by specific autoantibodies such as anti-citrullinated peptide antibodies (ACPAs).<a class="elsevierStyleCrossRef" href="#bib0390"><span class="elsevierStyleSup">23</span></a> In a community-dwelling study looking at U.S. adults enrolled in the Multi-Ethnic Study of Atherosclerosis, RA-related autoimmunity was associated with both quantitative and qualitative asymptomatic ILD notably among ever smokers.<a class="elsevierStyleCrossRef" href="#bib0395"><span class="elsevierStyleSup">24</span></a> More recently, ACPAs have been identified in patients with IPF.<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">25</span></a> Positivity for IgA-ACPA was increased in two IPF cohorts compared with general population control individuals (21.3% and 24.8% <span class="elsevierStyleItalic">vs</span> 5.6%). Patients with IPF were more likely to be IgA-ACPA-positive than IgG-ACPA-positive (23.2% <span class="elsevierStyleItalic">vs</span> 8.3%).<a class="elsevierStyleCrossRef" href="#bib0400"><span class="elsevierStyleSup">25</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">Based on these findings, we can hypothesize that RA-ILD (and more specifically RA-UIP) shares) genetic susceptibility factors with IPF (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Exonic rare variants</span><p id="par0040" class="elsevierStylePara elsevierViewall">Following the hypothesis of a common genetic background between IPF and RA-ILD, a case control genetic association study investigated exonic rare variants in genes previously linked to familial pulmonary fibrosis (FPF).<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">26</span></a> Among the patients with 101 RA-ILD included, 12 (11.9%) had 13 WES-identified heterozygous mutations in the <span class="elsevierStyleItalic">TERT</span>, <span class="elsevierStyleItalic">RTEL1</span>, <span class="elsevierStyleItalic">PARN</span> or <span class="elsevierStyleItalic">SFTPC</span> coding regions. The burden test, based on 81 patients with RA-ILD and 1010 controls of European ancestry, revealed an excess of <span class="elsevierStyleItalic">TERT</span>, <span class="elsevierStyleItalic">RTEL1</span>, <span class="elsevierStyleItalic">PARN</span> or <span class="elsevierStyleItalic">SFTPC</span> rare variants in patients with RA-ILD (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3.17, 95% CI (1.53–6.12); <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>9.45<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">−2</span>).<a class="elsevierStyleCrossRef" href="#bib0405"><span class="elsevierStyleSup">26</span></a> Telomeres were shorter in patients with RA-ILD carrying a at least one <span class="elsevierStyleItalic">TERT</span>, <span class="elsevierStyleItalic">RTEL1</span> or <span class="elsevierStyleItalic">PARN</span> rare variant than in controls (<span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2.87<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">−2</span>). These findings support the probable contribution of FPF-linked genes to RA-ILD susceptibility. However, the study design (<span class="elsevierStyleItalic">i.e.</span> patients with RA-ILD <span class="elsevierStyleItalic">vs</span> unaffected individuals) did not allow to distinguish if the excess of FPF-linked genes exonic rare variants contributes to the risk of ILD in patients with RA or to the risk of overall RA. This last question implies that a genetic association study should be performed by comparing patients with RA-ILD and patients with RA-noILD.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Common variants</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">MUC5B rs35705950</span><p id="par0045" class="elsevierStylePara elsevierViewall">The gain-of-function promoter variant rs35705950<a class="elsevierStyleCrossRef" href="#bib0410"><span class="elsevierStyleSup">27</span></a> (G>T) of the gene encoding mucin 5B (<span class="elsevierStyleItalic">MUC5B</span>) is the strongest genetic risk factor for IPF, observed in at least 50% of the patients with IPF and accounting for near 30% of the overall risk of developing this disease.<a class="elsevierStyleCrossRefs" href="#bib0415"><span class="elsevierStyleSup">28–36</span></a> The <span class="elsevierStyleItalic">MUC5B</span> promoter variant is associated with increased expression of <span class="elsevierStyleItalic">MUC5B</span> in lung parenchyma of unaffected controls and cases of IPF.<a class="elsevierStyleCrossRefs" href="#bib0410"><span class="elsevierStyleSup">27,28</span></a> Following the similarities between RA-ILD and IPF and the possibility of a common genetic background, the <span class="elsevierStyleItalic">MUC5B</span> promoter variant rs35705950 was tested for association with RA-ILD.</p><p id="par0050" class="elsevierStylePara elsevierViewall">To test this hypothesis, a multi-ethnic association study of was performed in a large population.<a class="elsevierStyleCrossRef" href="#bib0460"><span class="elsevierStyleSup">37</span></a> Using a discovery population and multi-ethnic validation case series, the association of <span class="elsevierStyleItalic">MUC5B</span> rs35705950 was tested in 620 patients with RA-ILD, 614 patients with RA and without ILD, and 5448 unaffected controls. The derivation population revealed an association of the <span class="elsevierStyleItalic">MUC5B</span> promoter variant minor allele with RA-ILD when compared to unaffected controls (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3.8 95%CI (2.8–5.2); <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>9.7<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">−17</span>). Similar to the derivation population, the <span class="elsevierStyleItalic">MUC5B</span> promoter variant was significantly over-represented among the patients with RA-ILD in the multi-ethnic validation population when compared to unaffected controls (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5.5 95%CI (4.2–7.2); <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4.7<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">−35</span>), and when the derivation and validation populations were combined (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>4.7 95%CI (3.9–5.8); <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.3<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">−49</span>). Additionally, the <span class="elsevierStyleItalic">MUC5B</span> rs35705950 T risk allele was found to increase the risk of ILD among patients with RA (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3.1 95%CI (1.8–5.4); <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>7.4<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">−5</span>). Of interest and concordant with the <span class="elsevierStyleItalic">a priori</span> hypothesis of a shared genetic background between RA-UIP and IPF, the association of the <span class="elsevierStyleItalic">MUC5B</span> promoter variant with RA-ILD was restricted to the subset of patients with RA-UIP with a signal association of similar magnitude and direction to that previously reported in IPF: OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>6.1 95%CI (2.9–13.1); <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2.5<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">−6</span>.</p><p id="par0055" class="elsevierStylePara elsevierViewall">Additional exploratory analyses found that other IPF risk variants (<span class="elsevierStyleItalic">TOLLIP</span> rs5743890 and <span class="elsevierStyleItalic">IVD</span> rs2034650) were also preliminarily associated with RA-ILD. The association between <span class="elsevierStyleItalic">MUC5B</span> rs35705950 and RA-ILD was independently replicated in the Finnish population. In this study, the authors estimated the lifetime risk of developing RA-ILD with respect to the <span class="elsevierStyleItalic">MUC5B</span> promoter variant. In patients with RA, <span class="elsevierStyleItalic">MUC5B</span> was found as a strong risk factor of ILD with a HR of 2.27 95%CI (1.75–2.95).<a class="elsevierStyleCrossRef" href="#bib0465"><span class="elsevierStyleSup">38</span></a> Even if the minor allele frequency of <span class="elsevierStyleItalic">MUC5B</span> rs35705950 is very low in the Asian population, the association was also replicated with RA-UIP (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3.5 95%CI (1.2–10.4); <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.023).<a class="elsevierStyleCrossRef" href="#bib0470"><span class="elsevierStyleSup">39</span></a> Interestingly, the <span class="elsevierStyleItalic">MUC5B</span> rs35705950 variant has not been associated with systemic sclerosis-related ILD (SSc-ILD)<a class="elsevierStyleCrossRef" href="#bib0435"><span class="elsevierStyleSup">32</span></a> nor antisynthetase syndrome,<a class="elsevierStyleCrossRef" href="#bib0475"><span class="elsevierStyleSup">40</span></a> two diseases in which the predominant pattern is NSIP. Conversely, <span class="elsevierStyleItalic">MUC5B</span> rs35705950 contributes to the risk of asbestosis and myeloperoxidase-antineutrophil cytoplasmic antibody-associated vasculitis-related ILD, two diseases in which, like for RA-ILD, the UIP pattern is prevalent.<a class="elsevierStyleCrossRefs" href="#bib0480"><span class="elsevierStyleSup">41,42</span></a> These findings suggest that the <span class="elsevierStyleItalic">MUC5B</span> rs35705950 variant may prove to be a generalized risk factor for UIP, and not simply limited to IPF and RA-UIP.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Additional common variants of potential interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">Recently, a genome-wide association study performed in the japanese population that included 358 patients with RA-ILD and 4550 patients with RA without ILD (RA-noILD) identified the <span class="elsevierStyleItalic">RPA3-UMAD1</span> rs12702634 single nucleotide polymorphism (SNP) as a new RA-ILD risk variant (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2.04 95%CI (1.59–2.60); <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.5<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>10<span class="elsevierStyleSup">−8</span>).<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">43</span></a> Sub-analysis according to chest HRCT pattern found a stronger association in patients with RA-ILD having a UIP and probable UIP patterns: OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.86 95%CI (0.97–3.58); <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.062 and OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>2.26 95%CI (1.36–3.73); <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.0015, respectively. The <span class="elsevierStyleItalic">RPA3-UMAD1</span> rs12702634 SNP is located in the intronic region of <span class="elsevierStyleItalic">RPA3</span> and <span class="elsevierStyleItalic">UMAD1</span> within an enhancer possibly involved in the modulation of gene expression in immune cells.<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">43</span></a> This association was not replicated in an independent Japanese population.<a class="elsevierStyleCrossRef" href="#bib0495"><span class="elsevierStyleSup">44</span></a> To date, the contribution of <span class="elsevierStyleItalic">RPA3-UMAD1</span> rs12702634 to the genetic architecture of RA-ILD in non-Asian populations remains to be determined.</p><p id="par0065" class="elsevierStylePara elsevierViewall">A recent GWAS, performed in a relatively small population (<span class="elsevierStyleItalic">i.e.</span> 60 patients with RA-ILD compared to 1058 patients with RA-noILD) and without a replication step found the association between <span class="elsevierStyleItalic">MUC5B</span> rs35705950 and RA-ILD and suggested that 3 additional known IPF-risk variants (<span class="elsevierStyleItalic">TOLLIP</span> rs111521887, <span class="elsevierStyleItalic">FAM13A</span> rs2609255 and <span class="elsevierStyleItalic">TERT</span> rs2736100) contributed to the risk of ILD in European RA.<a class="elsevierStyleCrossRef" href="#bib0500"><span class="elsevierStyleSup">45</span></a> A case-control association study investigating <span class="elsevierStyleItalic">FAM13A</span> rs2609255 in the Japanese RA population (208 patients with RA-ILD <span class="elsevierStyleItalic">vs</span> 420 patients with RA-noILD) found a significant contribution of <span class="elsevierStyleItalic">FAM13A</span> rs2609255 to the risk of RA-ILD (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>1.53, 95% CI (1.12–2.11); <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.0092). <span class="elsevierStyleItalic">FAM13A</span> rs2609255 was significantly associated with RA-UIP in male patients (OR 3.65, 95% CI 1.52–8.73; <span class="elsevierStyleItalic">P</span><span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.0043) under a recessive model.<a class="elsevierStyleCrossRef" href="#bib0505"><span class="elsevierStyleSup">46</span></a></p><p id="par0070" class="elsevierStylePara elsevierViewall">Lastly, a case–control genetic association study of a Japanese population, not including a replication step, found an association between <span class="elsevierStyleItalic">HLA-DRB1*1502</span> and RA-ILD.<a class="elsevierStyleCrossRef" href="#bib0510"><span class="elsevierStyleSup">47</span></a> A recent intra-case genome-wide association study performed in the same population and comparing patient with RA with and without ILD did not find a significant association between RA-ILD and the <span class="elsevierStyleItalic">HLA-DRB1</span> locus.<a class="elsevierStyleCrossRef" href="#bib0490"><span class="elsevierStyleSup">43</span></a> Therefore, the exact role of the <span class="elsevierStyleItalic">HLA-DRB1</span> locus to the RA-ILD susceptibility remains to be elucidated.</p><p id="par0075" class="elsevierStylePara elsevierViewall">The current state of knowledge on the genetic architecture of RA-ILD is represented in <a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>.</p><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0080" class="elsevierStylePara elsevierViewall">Finally, the genetic background of RA-ILD probably differs from that of other autoimmune diseases-related ILD. For example, the main genetic risk factors for SSc-ILD involve variants located in genes encoding actors of the type 1 interferon pathway and, more broadly, in innate and adaptive immunity<a class="elsevierStyleCrossRef" href="#bib0515"><span class="elsevierStyleSup">48</span></a> which do not appear to contribute to the risk of RA-ILD in the two GWAS studies reported.</p></span></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Genetic risk factors and screening for RA-ILD</span><p id="par0085" class="elsevierStylePara elsevierViewall">The relatively high prevalence of asymptomatic ILD seen on chest HRCT scan in patients with RA shows that a detection based on only respiratory symptoms is not relevant. symptomatic, RA-ILD should be assessed by chest HRCT scan allowing for (1) the diagnosis of ILD and (2) both qualitative (HRCT patterns) and quantitative (extent) assessment of ILD.<a class="elsevierStyleCrossRefs" href="#bib0520"><span class="elsevierStyleSup">49–52</span></a> Consequently, the challenge of RA-ILD screening arises only in the context of the absence of respiratory symptoms in selected patients with RA at particularly high-risk of ILD.<a class="elsevierStyleCrossRefs" href="#bib0520"><span class="elsevierStyleSup">49,53</span></a> Recently developed therapeutic interventions could help reduce the decline of lung function in patients with a progressive condition.<a class="elsevierStyleCrossRef" href="#bib0545"><span class="elsevierStyleSup">54</span></a> Early identification of ILD in patients with RA may inform our understanding of disease pathogenesis and may provide a therapeutic window of opportunity to prevent progression to symptomatic RA-ILD. The identification of high-risk RA with RA who may benefit from HRCT screening at an early and asymptomatic stage of the disease is an important unmet need in RA-ILD.<a class="elsevierStyleCrossRef" href="#bib0550"><span class="elsevierStyleSup">55</span></a></p><p id="par0090" class="elsevierStylePara elsevierViewall">To date only 2 studies aimed to identify independent risk factors (including genetic factors) for asymptomatic ILD in patients with RA. The first is a prospective study involving 184 patients with RA without known ILD. All the individuals had lung imaging performed with HRCT scans and were genotyped for <span class="elsevierStyleItalic">MUC5B</span> rs35705950. In this population, the majority were RF and anti-CCP positive with a median RA duration of 8.5 years and the prevalence of asymptomatic ILD was 21%. Multiple logistic regression models found <span class="elsevierStyleItalic">MUC5B</span> rs35705950 as an independent risk factor for asymptomatic RA-ILD.<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">11</span></a> The second study, included a derivation and a replication population constituted of patients without pulmonary symptoms from 2 prospective RA cohorts who underwent chest HRCT scans. All patients were genotyped for <span class="elsevierStyleItalic">MUC5B</span> rs35705950. Derivation and replication populations included 163 and 89 patients with RA, respectively. The prevalence of asymptomatic RA-ILD was 19.0% and 16.9%, respectively. Briefly, independent risk factors for asymptomatic RA-ILD were the <span class="elsevierStyleItalic">MUC5B</span> rs35705950 T risk allele (odds ratio (OR<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>3.74; 95% CI (1.37–10.39), male sex, older age at RA onset and increased mean DAS28-ESR. A derived risk score was developed and validated in the replication cohort. Excluding <span class="elsevierStyleItalic">MUC5B</span> rs35705950 from the model provided a lower goodness of fit supporting its important contribution to asymptomatic RA-ILD risk. All these findings could help clinicians in their daily practice and more extensively for future recommendations in RA-ILD screening.</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Conclusion</span><p id="par0095" class="elsevierStylePara elsevierViewall">RA-ILD is a multifactorial disease whose determinism involves environmental and genetic factors. Over the last decade, there has been growing interest in identifying phenotypic markers of RA associated with RA-ILD. It is only very recently that we have become interested in understanding the genetic architecture of the disease. To date, <span class="elsevierStyleItalic">MUC5B</span> rs35705950 remains the main genetic risk factor which seems likely to be of interest for screening for the disease.</p><p id="par0100" class="elsevierStylePara elsevierViewall">Future genome-wide association studies are needed to establish the genetic background of RA-ILD. It should be noted that this genetic background will probably be distinct for each specific susbset of the disease. Indeed, RA-ILD is incorrectly considered to be a single entity, whereas it is formally heterogeneous, as illustrated by the variability of the HRCT patterns. One illustration of this distinct genetic background would be the exclusive association of <span class="elsevierStyleItalic">MUC5B</span> rs35705950 with RA-UIP.</p><p id="par0105" class="elsevierStylePara elsevierViewall">Finally, an effort should be made to identify future prognostic factors for RA-ILD, including the potential role of specific genetic variants. International collaborative efforts are needed to address these issues.</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Conflict of interests</span><p id="par0110" class="elsevierStylePara elsevierViewall">The authors declare that they have no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres2152605" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1827062" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres2152606" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1827061" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Epidemiology" ] 5 => array:3 [ "identificador" => "sec0010" "titulo" => "Known genetic architecture of RA-ILD" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "RA-ILD is a complex disease" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Similarities between RA-ILD and idiopathic pulmonary fibrosis" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Exonic rare variants" ] 3 => array:3 [ "identificador" => "sec0030" "titulo" => "Common variants" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "MUC5B rs35705950" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Additional common variants of potential interest" ] ] ] ] ] 6 => array:2 [ "identificador" => "sec0045" "titulo" => "Genetic risk factors and screening for RA-ILD" ] 7 => array:2 [ "identificador" => "sec0050" "titulo" => "Conclusion" ] 8 => array:2 [ "identificador" => "sec0055" "titulo" => "Conflict of interests" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2023-06-13" "fechaAceptado" => "2023-12-18" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1827062" "palabras" => array:3 [ 0 => "Rheumatoid arthritis" 1 => "Interstitial lung disease" 2 => "MUC5B" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1827061" "palabras" => array:3 [ 0 => "Artritis reumatoide" 1 => "Enfermedad pulmonar intersticial" 2 => "MUC5B" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Recent advances in deciphering the genetic architecture of RA-ILD support the hypothesis of RA-ILD as a complex disease with a heterogeneous phenotype encompassing at least the usual interstitial pneumonia (UIP) and non-UIP high-resolution CT patterns. The results of genetic studies support the hypothesis of a common genetic background between idiopathic pulmonary fibrosis (IPF) and RA-ILD, and more specifically RA-UIP, a subset of the disease associated with a poor prognosis. Overall, these findings suggest the existence of shared pathogenic pathways between IPF and RA-ILD providing new opportunities for future intervention in RA-ILD, particularly with drugs that have been shown to be active in IPF.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los recientes avances en el desciframiento de la arquitectura genética de la artritis reumatoide asociada a enfermedad pulmonar intersticial (EPI-AR) apoyan la hipótesis de que la EPI-AR es una enfermedad compleja, con un fenotipo heterogéneo, que abarca al menos los patrones de neumonía intersticial habitual (NIU) y de TC de alta resolución no NIU. Los resultados de los estudios genéticos apoyan la hipótesis de un trasfondo genético común entre la fibrosis pulmonar idiopática (FPI) y la EPI-AR, y más concretamente la NIU-AR, un subconjunto de la enfermedad asociado a un mal pronóstico. En conjunto, estos hallazgos sugieren la existencia de vías patogénicas compartidas entre la FPI y la EPI-AR que proporcionan nuevas oportunidades para futuras intervenciones en la EPI-AR, particularmente con fármacos que han demostrado ser activos en la FPI.</p></span>" ] ] "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0195" class="elsevierStylePara elsevierViewall">The following are the supplementary material to this article:<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Supplementary material" "identificador" => "sec0085" ] ] ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2223 "Ancho" => 1675 "Tamanyo" => 196903 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Similarities between idiopathic pulmonary fibrosis and rheumatoid arthritis associated interstitial lung disease. RA-ILD: rheumatoid arthritis associated interstitial lung disease; IPF: idiopathic pulmonary fibrosis.</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1250 "Ancho" => 2500 "Tamanyo" => 170187 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Genetic architecture of rheumatoid arthritis associated interstitial lung disease.</p>" ] ] 2 => array:5 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:2 [ "fichero" => "mmc1.pdf" "ficheroTamanyo" => 321797 ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:55 [ 0 => array:3 [ "identificador" => "bib0280" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occurrence of extraarticular disease manifestations is associated with excess mortality in a community based cohort of patients with rheumatoid arthritis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "C. 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Genetics of autoimmune-associated interstitial lung diseases: A focus on rheumatoid arthritis
Genética de las enfermedades pulmonares intersticiales autoinmunes asociadas: un enfoque sobre la artritis reumatoide