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Inicio Revista Española de Anestesiología y Reanimación (English Edition) Etomidate in the treatment of Cushing syndrome
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Vol. 70. Issue 8.
Pages 473-476 (October 2023)
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Vol. 70. Issue 8.
Pages 473-476 (October 2023)
Case report
Etomidate in the treatment of Cushing syndrome
Etomidato en el tratamiento del síndrome de Cushing
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3
N. Vergara Molinaa, N. Ruiz Andrésb, N. Casas Martína,
Corresponding author
, C. Ruano Suáreza, I. Castelo Korroa, A. Martínez Ruiza
a Hospital Universitario Cruces, Barakaldo, Bizkaia, Spain
b Hospital Universitario Marqués de Valdecilla, Santander, Spain
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Abstract

Cushing syndrome is a metabolic disease caused by chronic exposure to high levels of glucocorticoids. It can present as an endocrine emergency due to a rapid increase in circulating cortisol leading to increased risk of cardiovascular disease and infection. Etomidate rapidly reduces plasma cortisol levels by inhibiting the action of 11β-hidroxilase. We report the case of a patient with severe hypercortisolaemia accompanied by metabolic and psychiatric disorders in whom administration of etomidate reduced preoperative levels of cortisol.

Keywords:
Cushing syndrome
Etomidate
Hypercortisolaemia
Anaesthesiology
Resumen

El Síndrome de Cushing es una enfermedad metabólica causada por la exposición crónica a niveles elevados de glucocorticoides. Se puede presentar como una emergencia endocrina por un aumento rápido de los niveles de cortisol en sangre, con aumento de la morbimortalidad por enfermedad cardiovascular e infecciones. El Etomidato es un fármaco que permite el control rápido de los niveles de cortisol plasmáticos, por inhibición del enzima 11β-hidroxilasa. Presentamos un caso clínico de hipercortisolemia severa, acompañada de alteraciones metabólicas y neuropsiquiátricas, en el que el control de niveles de cortisol previo a cirugía se consiguió con perfusión de etomidato.

Palabras clave:
Síndrome de Cushing
Etomidato
Hipercortisolismo
Anestesiología

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