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Pacientes críticos COVID-19 atendidos por anestesiólogos en el Noroeste de España: estudio multicéntrico, prospectivo, observacional
Critically ill COVID-19 patients attended by anesthesiologists in northwestern Spain: a multicenter prospective observational study
M. Taboadaa,
Autor para correspondencia
manutabo@yahoo.es

Autor para correspondencia.
P. RamabR. Pita-RomerocE. MorenodS. LealeM. VarelafM. CidgV. CaruezoaS. Alvarado de la TorrebM. CorujeiracA. SarmientodB. DomínguezeP. DiazfL. CánovasgM. López SánchezbE. VilascA. RodríguezdL. FreireeS. DomínguezfA. BalujaaP.G. Atanassoffh
a Servicio de Anestesiología y Reanimación, Hospital Clínico Universitario de Santiago, Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, España
b Servicio de Anestesiología y Reanimación, Complejo Hospitalario Universitario A Coruña, La Coruña, España
c Servicio de Anestesiología y Reanimación, Complejo Hospitalario Universitario de Vigo, Vigo, España
d Servicio de Anestesiología y Reanimación, Hospital Arquitecto Marcide de Ferrol, Ferrol, España
e Servicio de Anestesiología y Reanimación, Hospital POVISA de Vigo, Vigo, España
f Servicio de Anestesiología y Reanimación, Complejo Hospitalario Universitario Pontevedra, Pontevedra, España
g Servicio de Anestesiología y Reanimación, Complejo Hospitalario Universitario Ourense, Orense, España
h Servicio de Anestesiología, Universidad de Basilea, Basilea, Suiza
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">Desde la aparici&#243;n de la infecci&#243;n por el nuevo coronavirus &#40;SARS-CoV-2&#41; en Wuhan&#44; China&#44; en diciembre de 2019&#44; &#233;sta se ha extendido r&#225;pidamente por China y muchos otros pa&#237;ses<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">1-2</span></a>&#46; El 31 de enero 2020&#44; Espa&#241;a confirm&#243; su primer paciente con COVID-19&#44; y Galicia&#44; una peque&#241;a regi&#243;n ubicada al Noroeste del pa&#237;s&#44; aproximadamente un mes despu&#233;s&#46; Galicia vivi&#243; un incremento de infecciones graves con numerosos ingresos a la UCI antes del 28 de marzo de 2020&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Varios estudios han aportado datos sobre pacientes cr&#237;ticamente enfermos con COVID-19<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">3-14</span></a>&#46; La mayor&#237;a de ellos describen las caracter&#237;sticas cl&#237;nicas de los pacientes con COVID-19 en el hospital o la UCI&#44; adem&#225;s del porcentaje de pacientes que requieren ventilaci&#243;n mec&#225;nica&#44; as&#237; como las tasas de mortalidad<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">4-14</span></a>&#46; Sin embargo&#44; en muchos de estos estudios solo se realizaron breves seguimientos&#46; Adem&#225;s&#44; no proporcionaron datos sobre los medicamentos administrados como anticoagulantes&#44; antibi&#243;ticos&#44; agentes antivirales o corticoides&#59; ni complicaciones como infecciones&#44; eventos tromboemb&#243;licos&#44; barotrauma o reintubaciones&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Por lo tanto&#44; se realiz&#243; un estudio observacional&#44; prospectivo&#44; multic&#233;ntrico&#44; que incluy&#243; a pacientes cr&#237;ticamente enfermos&#44; que ten&#237;an infecci&#243;n por COVID-19 y que requirieron ingreso en una UCI de Anestesiolog&#237;a en siete hospitales diferentes en el Noroeste de Espa&#241;a&#46; Nuestro objetivo fue evaluar el curso cl&#237;nico en UCI de estos pacientes&#44; su resultado&#44; complicaciones&#44; as&#237; como los tratamientos utilizados&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">M&#233;todos</span><p id="par0020" class="elsevierStylePara elsevierViewall">Entre el 21 de marzo y el 19 de abril de 2020&#44; evaluamos prospectivamente todos los pacientes con casos de COVID-19 en estado cr&#237;tico ingresados en las UCI de Anestesia de siete hospitales ubicados en Galicia&#44; Noroeste de Espa&#241;a&#46; El resultado cl&#237;nico se control&#243; hasta el 6 de mayo de 2020&#44; &#250;ltima fecha de seguimiento&#46; Se defini&#243; un caso confirmado de COVID-19 por un resultado positivo en una reacci&#243;n en cadena de la polimerasa con transcriptasa inversa &#40;RTPCR&#41;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">15</span></a>&#46; El Comit&#233; de &#201;tica de Galicia &#40;c&#243;digo 2020-188&#41; aprob&#243; este estudio y debido a la r&#225;pida aparici&#243;n de esta enfermedad infecciosa&#44; se elimin&#243; la necesidad de consentimiento informado de los pacientes&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Se recogieron los siguientes datos de todos los pacientes al ingreso en UCI&#58; edad&#44; sexo&#44; altura&#44; enfermedades concomitantes y tratamientos domiciliarios&#59; adem&#225;s de la puntuaci&#243;n de la escala de evaluaci&#243;n de la fisiolog&#237;a aguda y salud cr&#243;nica <span class="elsevierStyleSmallCaps">ii</span> &#40;APACHE <span class="elsevierStyleSmallCaps">ii</span>&#41;&#44; la presi&#243;n arterial parcial de ox&#237;geno &#40;PaO<span class="elsevierStyleInf">2</span>&#41;&#44; la fracci&#243;n de ox&#237;geno inspirado &#40;FiO<span class="elsevierStyleInf">2</span>&#41;&#44; la relaci&#243;n PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span> y pruebas de laboratorio iniciales &#40;hemograma&#44; bioqu&#237;mica s&#233;rica&#44; enzimas mioc&#225;rdicas&#44; interleuquina-6&#44; ferritina s&#233;rica&#44; procalcitonina&#44; lactato deshidrogenasa&#44; d&#237;mero D&#44; prote&#237;na C-reactiva&#41;&#46; La evaluaci&#243;n adicional consisti&#243; en la presencia de infecciones coexistentes&#44; tiempo desde la parici&#243;n de los s&#237;ntomas iniciales hasta el ingreso en el hospital y en la UCI y la evaluaci&#243;n de la radiograf&#237;a de t&#243;rax&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Durante la estancia en UCI evaluamos el resultado global de los pacientes&#44; su medicaci&#243;n &#40;vasopresores&#44; antibi&#243;ticos&#44; antivirales&#44; corticoides&#44; anticoagulantes&#44; etc&#46;&#41;&#44; el modo de apoyo respiratorio &#40;ventilaci&#243;n mec&#225;nica invasiva&#44; ventilaci&#243;n no invasiva&#44; c&#225;nulas nasales de alto flujo&#41;&#44; el uso de oxigenaci&#243;n por membrana extracorp&#243;rea &#40;ECMO&#41;&#44; el uso de terapia de reemplazo renal&#44; el uso de dec&#250;bito prono en pacientes despiertos o intubados&#44; la necesidad de traqueostom&#237;a para ventilaci&#243;n mec&#225;nica prolongada &#40;traqueotom&#237;a quir&#250;rgica frente a traqueotom&#237;a percut&#225;nea por dilataci&#243;n&#41;&#44; los valores de laboratorio m&#225;s altos durante el ingreso en UCI &#40;interleuquina-6&#44; ferritina s&#233;rica&#44; procalcitonina&#44; lactato deshidrogenasa&#44; d&#237;mero D&#44; prote&#237;na C-reactiva&#41;&#44; las complicaciones &#40;infecci&#243;n adquirida en UCI&#44; complicaciones tromboemb&#243;licas&#44; necesidad de reintubaci&#243;n&#44; lesi&#243;n renal aguda que requiere terapia de reemplazo renal&#44; neumot&#243;rax&#44; reingreso en UCI&#44; etc&#46;&#41; y el resultado en UCI que incluy&#243; el n&#250;mero de pacientes que fallecieron&#44; los que fueron dados de alta y los que a&#250;n permanec&#237;an en la unidad al finalizar el seguimiento al 6 de mayo de 2020&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Los autores dise&#241;aron el ensayo&#44; recopilaron los datos y realizaron el an&#225;lisis&#46; Todos los autores revisaron el manuscrito&#44; dan fe de su exactitud y la integridad de los datos&#44; y aprobaron la decisi&#243;n de enviar el manuscrito para su publicaci&#243;n&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">An&#225;lisis estad&#237;stico</span><p id="par0040" class="elsevierStylePara elsevierViewall">El objetivo principal del estudio fue describir el curso cl&#237;nico de los pacientes cr&#237;ticos enfermos por COVID-19 ingresados en las UCI de Anestesia de la regi&#243;n de Galicia durante el pico de la pandemia de marzo a abril de 2020&#44; los tratamientos utilizados&#44; las complicaciones y resultados&#46; Los pacientes y los datos de seguimiento se recopilaron hasta que m&#225;s del 85&#37; de los pacientes con COVID-19 experimentaron los resultados de inter&#233;s &#40;murieron en la UCI o fueron dados de alta de la unidad&#41;&#46; Como objetivo secundario se compararon las caracter&#237;sticas de los pacientes entre aquellos que sobrevivieron y los fallecidos durante el ingreso en la UCI&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Las variables num&#233;ricas se describieron mediante mediana y rango intercuart&#237;lico&#46; Las variables categ&#243;ricas fueron descritas como frecuencia y porcentaje&#46; Basado en la prueba de Levene&#44; la prueba de hip&#243;tesis nula no param&#233;trica se realiz&#243; debido a que las variables continuas son heteroced&#225;sticas frente a factores categ&#243;ricos&#46; Las variables num&#233;ricas y categ&#243;ricas se compararon con el uso de las pruebas pareadas de Wilcoxon o Kruskal-Wallis&#44; y las variables factoriales se compararon con la prueba de &#967;<span class="elsevierStyleSup">2</span> de Pearson&#46; Todos los valores de p obtenidos fueron penalizados con el procedimiento Benjamini-Hochberg&#46; Todos los an&#225;lisis se realizaron en R v&#46;3&#46;6&#174;&#46;</p></span></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Resultados</span><p id="par0050" class="elsevierStylePara elsevierViewall">Entre el 21 de marzo y el 19 de abril de 2020&#44; 97 pacientes cr&#237;ticamente enfermos por COVID-19 fueron ingresados en las UCI de Anestesia de siete hospitales del Noroeste de Espa&#241;a&#46; La <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a> muestra las caracter&#237;sticas de los pacientes&#44; sus enfermedades coexistentes&#44; medicaci&#243;n cr&#243;nica y evaluaci&#243;n de la radiograf&#237;a de t&#243;rax en el momento del ingreso a la UCI&#46; La mediana de edad de los pacientes fue de 69 &#40;61-73&#41; a&#241;os&#46; La edad avanzada se asoci&#243; con el fallecimiento durante la estancia en UCI &#40;<a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#41;&#46; Las patolog&#237;as coexistentes m&#225;s frecuentes fueron la hipertensi&#243;n arterial &#40;56&#44;7&#37;&#41;&#44; la dislipemia &#40;43&#44;3&#37;&#41; y la obesidad &#40;39&#44;2&#37;&#41;&#46; Se obtuvo una radiograf&#237;a de t&#243;rax de todos los pacientes y el 85&#44;6&#37; ten&#237;a hallazgos radiol&#243;gicos con infiltrados parcheados bilaterales&#46; Los valores de las pruebas de laboratorio al ingreso en la UCI y los niveles m&#225;s altos obtenidos durante la estancia en UCI se muestran en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; Un recuento linfocitario m&#225;s bajo al ingreso y unos niveles m&#225;s altos de procalcitonina durante la estancia en la UCI se asociaron con mal pron&#243;stico&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0055" class="elsevierStylePara elsevierViewall">La evoluci&#243;n cl&#237;nica y los tratamientos durante la estancia en la UCI se resumen en la <a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#46; La mediana de tiempo desde el inicio de los s&#237;ntomas hasta el ingreso hospitalario y en la UCI fue de 7 &#40;5-10&#41; d&#237;as y de 10 &#40;7-12&#41; d&#237;as&#44; respectivamente&#46; La puntuaci&#243;n media de la escala APACHE <span class="elsevierStyleSmallCaps">ii</span> de todos los pacientes fue de 15 &#40;12-20&#41;&#46; El 6 de mayo de 2020&#44; despu&#233;s de una mediana de seguimiento de 42 &#40;34-45&#41; d&#237;as&#44; del total 97 de pacientes&#44; 15 &#40;15&#44;5&#37;&#41; pacientes hab&#237;an fallecido&#44; 73 &#40;75&#44;2&#37;&#41; hab&#237;an sido dados de alta de UCI&#44; y 9 de ellos &#40;9&#44;3&#37;&#41; a&#250;n se encontraban en esta unidad&#46; La incidencia acumulada de pacientes fallecidos en UCI o dados de alta de la UCI se presenta en la <a class="elsevierStyleCrossRef" href="#fig0005">figura 1</a>&#46; La duraci&#243;n media de la estancia en la UCI entre los fallecidos fue de 18 &#40;14-28&#41; d&#237;as&#46; De los 73 pacientes dados de alta de la UCI&#44; un paciente &#40;1&#44;4&#37;&#41; falleci&#243; en el hospital fuera de la UCI&#44; 10 &#40;13&#44;7&#37;&#41; permanec&#237;an hospitalizados y 62 &#40;84&#44;9&#37;&#41; fueron dados de alta del hospital&#46; Cuatro pacientes &#40;5&#44;5&#37;&#41; fueron reingresados en UCI durante la estancia hospitalaria&#46;</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">La duraci&#243;n media de la estancia en la UCI y la estancia hospitalaria fue de 14 &#40;9-21&#41; d&#237;as y 27 &#40;19-38&#41; d&#237;as&#44; respectivamente&#46; Durante la estancia en UCI&#44; 80 de ellos &#40;82&#44;5&#37;&#41; recibieron ventilaci&#243;n mec&#225;nica&#44; 63 &#40;64&#44;9&#37;&#41; requirieron vasopresores y 8 &#40;8&#44;2&#37;&#41; fueron tratados con terapia de reemplazo renal &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; Entre aquellos con ventilaci&#243;n mec&#225;nica&#44; 14 &#40;17&#44;5&#37;&#41; fallecieron&#44; 57 &#40;71&#44;2&#37;&#41; fueron dados de alta de la UCI&#44; y nueve &#40;11&#44;2&#37;&#41; permanecieron en la UCI&#46; La mediana de duraci&#243;n de la ventilaci&#243;n mec&#225;nica invasiva fue de 12 &#40;7-18&#41; d&#237;as&#46; Veintid&#243;s pacientes &#40;22&#44;5&#37;&#41; requirieron traqueotom&#237;a para ventilaci&#243;n mec&#225;nica prolongada&#46; La ventilaci&#243;n en dec&#250;bito prono se utiliz&#243; con frecuencia tanto en pacientes intubados como en pacientes en ventilaci&#243;n espont&#225;nea &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; La mayor&#237;a de los 97 pacientes recibi&#243; medicaci&#243;n antiviral&#44; antibi&#243;ticos&#44; anticoagulantes y corticoides &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">tabla 2</a>&#41;&#46; Se administr&#243; tocilizumab en 56 &#40;57&#44;3&#37;&#41; pacientes&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Las complicaciones se resumen en la <a class="elsevierStyleCrossRef" href="#tbl0015">tabla 3</a>&#46; Las complicaciones m&#225;s frecuentes fueron infecciones adquiridas en UCI &#40;52&#44;6&#37;&#41;&#44; episodios tromboemb&#243;licos &#40;16&#44;5&#37;&#41;&#44; reintubaci&#243;n &#40;9&#44;3&#37;&#41;&#44; lesi&#243;n renal aguda que requiri&#243; terapia renal sustitutiva &#40;8&#44;2&#37;&#41; y neumot&#243;rax &#40;7&#44;2&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0070" class="elsevierStylePara elsevierViewall">La <a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a> resume los resultados y tratamientos administrados en los principales estudios de pacientes cr&#237;ticos con COVID-19 ingresados en la UCI en diferentes pa&#237;ses&#46;</p><elsevierMultimedia ident="tbl0020"></elsevierMultimedia></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Discusi&#243;n</span><p id="par0075" class="elsevierStylePara elsevierViewall">En este estudio observacional multic&#233;ntrico&#44; se describe el curso cl&#237;nico en UCI de 97 pacientes cr&#237;ticamente enfermos con COVID-19&#59; 46 d&#237;as despu&#233;s del primer ingreso en UCI y despu&#233;s de un seguimiento medio de 42 &#40;34-45&#41; d&#237;as&#44; 15 &#40;15&#44;5&#37;&#41; pacientes hab&#237;an fallecido&#44; 73 &#40;75&#44;5&#37;&#41; hab&#237;an sido dados de alta y 9 &#40;9&#44;3&#37;&#41; continuaban todav&#237;a en la UCI&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">La tasa de mortalidad fue similar a la notificada previamente en un gran hospital terciario en Mil&#225;n<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">13</span></a>&#44; pero menor que en otros centros &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">3&#44;14</span></a>&#46; La menor tasa de mortalidad del presente estudio en comparaci&#243;n con las anteriores puede deberse a varios factores&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">En primer lugar&#44; en el Noroeste de Espa&#241;a hubo una menor carga asistencial del sistema de salud en comparaci&#243;n con el norte de Italia<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">8</span></a>&#44; Wuhan<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">2&#44;4&#44;5&#44;14</span></a>&#44; Seattle<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">10</span></a> o Washington<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">11</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46; Los m&#233;dicos de estas regiones probablemente hayan necesitado trabajar al l&#237;mite de sus capacidades&#46; El r&#225;pido aumento en el n&#250;mero de casos excedi&#243; frecuentemente el n&#250;mero de camas de UCI o ventiladores disponibles&#44; reduciendo as&#237; las probabilidades de obtener un buen resultado en estos pacientes cr&#237;ticamente enfermos<a class="elsevierStyleCrossRef" href="#bib0275"><span class="elsevierStyleSup">16</span></a>&#46; En los siete hospitales participantes del presente estudio&#44; solo alrededor del 70&#37; de las camas de la UCI estaban ocupadas&#44; por lo que los m&#233;dicos pudieron trabajar en condiciones adecuadas y sin limitaciones de recursos&#46; Otra posible explicaci&#243;n que puede haber disminuido la mortalidad en nuestros pacientes&#44; puede haber sido el uso de medicamentos como corticoides y anticoagulantes&#44; adem&#225;s del empleo precoz de ventilaci&#243;n mec&#225;nica protectora en pacientes con SDRA y de la ventilaci&#243;n en dec&#250;bito prono&#44; tanto en pacientes intubados como en aquellos que se mantuvieron en ventilaci&#243;n espont&#225;nea&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">La mayor&#237;a de los pacientes con COVID-19 solo tienen s&#237;ntomas leves&#44; sin embargo&#44; algunos de ellos se deterioran y desarrollan insuficiencia respiratoria debido a un SDRA grave que requiere intubaci&#243;n y ventilaci&#243;n mec&#225;nica&#46; En el presente estudio&#44; 80 pacientes &#40;82&#44;5&#37;&#41; requirieron ventilaci&#243;n mec&#225;nica tras su ingreso en UCI&#46; La ventilaci&#243;n en dec&#250;bito prono con ciclos prolongados de tiempo &#40;&#8805;&#160;16&#160;h&#47;d&#237;a&#41; se utiliz&#243; en el 67&#44;5&#37; de ellos&#44; seg&#250;n lo recomendado por la Organizaci&#243;n Mundial de la Salud &#40;OMS&#41;<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">15</span></a>&#46; El dec&#250;bito prono es una estrategia disponible en el manejo de pacientes con SDRA&#44; que mejora la oxigenaci&#243;n y la supervivencia<a class="elsevierStyleCrossRefs" href="#bib0270"><span class="elsevierStyleSup">15&#44;17&#44;18</span></a>&#46; Explicaciones para esta mejor&#237;a en la oxigenaci&#243;n son que el procedimiento mejora la relaci&#243;n ventilaci&#243;n&#47;perfusi&#243;n pulmonar&#44; la presi&#243;n transpulmonar a lo largo del eje ventral-dorsal se distribuye de manera m&#225;s homog&#233;nea en comparaci&#243;n con la posici&#243;n supina&#44; y se promueve el reclutamiento de &#225;reas dorsales no ventiladas del pulm&#243;n<a class="elsevierStyleCrossRef" href="#bib0290"><span class="elsevierStyleSup">19</span></a>&#46; El dec&#250;bito prono en nuestros pacientes de UCI &#40;67&#44;5&#37;&#41; fue empleado con m&#225;s frecuencia de lo que se describi&#243; recientemente para otras poblaciones de pacientes similares&#58; 27&#37; en Lombard&#237;a<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">8</span></a>&#44; 28&#37; en Seattle<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">10</span></a> o 11&#37; en Wuhan<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">5&#44;14</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46; Una posible explicaci&#243;n para esta diferencia de uso puede ser la diferente carga de trabajo entre hospitales o regiones&#46; El posicionamiento en dec&#250;bito prono en un paciente intubado es complicado&#44; requiriendo de cuatro o cinco operadores para realizarlo&#46; Tras una mejora significativa de la oxigenaci&#243;n en pacientes con COVID-19 inicialmente intubados&#44; esta maniobra tambi&#233;n se utiliz&#243; en pacientes despiertos con SDRA moderado o severo&#44; intentando mejorar la oxigenaci&#243;n y evitar una intubaci&#243;n&#46; En teor&#237;a&#44; muchos de los mecanismos que explican una mejora de la oxigenaci&#243;n con el dec&#250;bito prono en pacientes intubados pueden ser aplicables a pacientes no intubados<a class="elsevierStyleCrossRefs" href="#bib0295"><span class="elsevierStyleSup">20-21</span></a>&#46; En pacientes despiertos&#44; esta maniobra es m&#225;s f&#225;cil&#46; Los pacientes pueden colocarse boca abajo por s&#237; mismos&#44; manteniendo la postura adecuada durante el mayor tiempo posible&#46; Los pacientes con COVID-19 y SDRA leve a moderado pueden colocarse en prono incluso fuera de la UCI&#44; por ejemplo en las salas de hospitalizaci&#243;n general&#44; mejorando la oxigenaci&#243;n&#44; y disminuyendo as&#237; el n&#250;mero de ingresos en UCI&#44; en caso de que las UCI solo dispongan de un n&#250;mero de camas escaso<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">13</span></a>&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Actualmente hay datos limitados sobre los mejores medicamentos para el tratamiento de los pacientes con COVID-19 y particularmente cu&#225;ndo comenzarlos&#46; Se han sugerido tratamientos antivirales&#44; antiinflamatorios&#44; anticoagulantes e inmunosupresores&#46; En una etapa temprana de la infecci&#243;n viral&#44; es decir&#44; en los cinco a ocho primeros d&#237;as desde el inicio de la enfermedad&#44; probablemente se deba recomendar la terapia antiviral&#59; mientras que m&#225;s tarde&#44; es decir&#44; ocho a 20 d&#237;as tras el inicio de la enfermedad&#44; debido a una respuesta inmune excesiva que conduce a un estado de hiperinflamaci&#243;n&#44; puede ser &#250;til el uso de agentes inmunomoduladores para reducir la inflamaci&#243;n sist&#233;mica<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">21-22</span></a>&#46; Como el ingreso en UCI se produjo 10 &#40;7-12&#41; d&#237;as despu&#233;s del inicio de los s&#237;ntomas y la duraci&#243;n media de la estancia en la UCI fue de 14 &#40;9-21&#41; d&#237;as&#44; es probable que la mayor&#237;a de nuestros pacientes cr&#237;ticamente enfermos estuvieran en la etapa de hiperinflamaci&#243;n&#46; Por lo tanto&#44; un enfoque v&#225;lido fue tratar la respuesta inmune con agentes como tocilizumab y&#47;o un corticoide<a class="elsevierStyleCrossRefs" href="#bib0300"><span class="elsevierStyleSup">21-22</span></a>&#46; En el presente estudio&#44; se administraron corticoides en el 93&#44;8&#37; de los casos&#44; de forma similar a un estudio anterior<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">13</span></a>&#44; pero en un porcentaje superior al de otras investigaciones<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">5&#44;10</span></a> &#40;<a class="elsevierStyleCrossRef" href="#tbl0020">tabla 4</a>&#41;&#46; La OMS<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">15</span></a> no recomienda el uso rutinario de corticoides en pacientes con COVID-19 fuera de los ensayos cl&#237;nicos&#44; y hay un debate sobre si deben usarse corticoides en pacientes con COVID-19<a class="elsevierStyleCrossRefs" href="#bib0310"><span class="elsevierStyleSup">23-29</span></a>&#46; Estudios realizados en pacientes con infecci&#243;n por H1N1 y el SARS encontraron que los corticoides redujeron las tasas de mortalidad y acortaron la duraci&#243;n de la estancia hospitalaria en pacientes cr&#237;ticamente enfermos<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">24-25</span></a>&#46; Un estudio retrospectivo reciente de 201 pacientes con COVID-19 en China revel&#243; que en aquellos con SDRA&#44; la metilprednisolona disminuy&#243; el riesgo de mortalidad<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">7</span></a>&#46; Por tanto&#44; varias sociedades m&#233;dicas y gu&#237;as recomiendan ahora el uso de corticoides en pacientes COVID-19 con SDRA<a class="elsevierStyleCrossRefs" href="#bib0315"><span class="elsevierStyleSup">24&#44;27&#44;28</span></a>&#46; Los m&#233;dicos de la <span class="elsevierStyleItalic">Chinese Thoracic Society</span> han desarrollado una declaraci&#243;n de consenso de expertos sobre el uso de corticoides en la neumon&#237;a 2019-CoV<a class="elsevierStyleCrossRef" href="#bib0315"><span class="elsevierStyleSup">24</span></a>&#46; El Instituto Nacional Italiano de las Enfermedades Infecciosas <span class="elsevierStyleItalic">L&#46; Spallanzani</span> tambi&#233;n recomienda el uso de corticoides para los afectados con SDRA<a class="elsevierStyleCrossRef" href="#bib0330"><span class="elsevierStyleSup">27</span></a>&#46; Los hallazgos <span class="elsevierStyleItalic">post mortem</span> como el edema pulmonar y la formaci&#243;n de membranas hialinas apoyan el uso de corticoides<a class="elsevierStyleCrossRef" href="#bib0340"><span class="elsevierStyleSup">29</span></a>&#46; Recientemente&#44; el Grupo Colaborativo RECOVERY observ&#243; que en pacientes hospitalizados con COVID-19 que reciben ventilaci&#243;n mec&#225;nica invasiva u ox&#237;geno&#44; el uso de dexametasona result&#243; en una menor mortalidad a los 28 d&#237;as<a class="elsevierStyleCrossRef" href="#bib0345"><span class="elsevierStyleSup">30</span></a>&#46; Es de esperar que los ensayos cl&#237;nicos futuros nos den respuesta a la adecuada administraci&#243;n de estos medicamentos&#44; incluida la eficacia de este tratamiento&#44; el momento adecuado de inicio del mismo y la dosis y duraci&#243;n apropiada de la terapia<a class="elsevierStyleCrossRefs" href="#bib0345"><span class="elsevierStyleSup">30-31</span></a>&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Estudios recientes se&#241;alaron la presencia de eventos tromboemb&#243;licos en pacientes que padec&#237;an COVID-19<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">32-34</span></a>&#46; En consecuencia&#44; la mayor&#237;a de los pacientes de la presente investigaci&#243;n recibieron dosis intermedias o altas de heparinas de bajo peso molecular&#46; Las complicaciones tromb&#243;ticas ocurrieron en el 16&#44;5&#37; de casos&#46; En pacientes COVID-19 severos&#44; un aumento del nivel de d&#237;mero D o un nivel elevado de citocinas proinflamatorias como la IL-6 fueron relacionados con un mal pron&#243;stico<a class="elsevierStyleCrossRef" href="#bib0370"><span class="elsevierStyleSup">35</span></a>&#46; Estos hallazgos pueden demostrar una relaci&#243;n entre trombosis e inflamaci&#243;n&#44; dos procesos que se refuerzan mutuamente&#46; Varios autores observaron que el COVID-19 puede predisponer a tromboembolismo venoso y arterial debido a una inflamaci&#243;n excesiva&#44; hipoxia&#44; inmovilizaci&#243;n y coagulaci&#243;n intravascular difusa<a class="elsevierStyleCrossRefs" href="#bib0355"><span class="elsevierStyleSup">32-34</span></a>&#46; En un estudio reciente de doce pacientes que fallecieron por COVID-19<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">32</span></a>&#44; los autores encontraron una alta incidencia de trombosis venosa profunda &#40;58&#37;&#41;&#46; Un tercio de estos pacientes tuvo una embolia pulmonar como causa directa de muerte&#46; Las complicaciones tromb&#243;ticas han sido descritas por diferentes autores&#46; Klok et al&#46;<a class="elsevierStyleCrossRef" href="#bib0355"><span class="elsevierStyleSup">32</span></a>&#44; informaron una incidencia del 31&#37; de complicaciones tromb&#243;ticas en pacientes de UCI con COVID-19&#46; Del mismo modo&#44; Helms et al&#46;<a class="elsevierStyleCrossRef" href="#bib0365"><span class="elsevierStyleSup">34</span></a>&#44; en un estudio de cohorte prospectivo multic&#233;ntrico en cuatro hospitales participantes&#44; observ&#243; que el 42&#37; de sus pacientes COVID-19 con SDRA&#44; desarroll&#243; complicaciones tromb&#243;ticas potencialmente mortales&#46; En estos estudios&#44; los autores sugieren el uso de dosis m&#225;s altas de medicaci&#243;n anticoagulante en pacientes con COVID-19 cr&#237;ticamente enfermos que las administradas habitualmente&#46; En este contexto&#44; algunos autores<a class="elsevierStyleCrossRefs" href="#bib0375"><span class="elsevierStyleSup">36-37</span></a> y varias sociedades profesionales<a class="elsevierStyleCrossRefs" href="#bib0385"><span class="elsevierStyleSup">38-39</span></a> ya han hecho recomendaciones para la terapia antitromb&#243;tica en pacientes con COVID-19&#46; Se necesitan ensayos aleatorios para determinar si los anticoagulantes sist&#233;micos proporcionan un beneficio de supervivencia en pacientes hospitalizados con COVID-19&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">El presente estudio tiene algunas limitaciones&#46; Esta investigaci&#243;n solo incluy&#243; a pacientes cr&#237;ticamente enfermos ingresados en UCI de Anestesiolog&#237;a de hospitales ubicados en el Noroeste de Espa&#241;a&#44; donde ten&#237;amos una presi&#243;n global menor sobre el sistema sanitario en comparaci&#243;n con otras regiones espa&#241;olas u otros pa&#237;ses&#46; Por tanto&#44; los resultados pueden no reflejar la experiencia de otras UCI en distintas regiones&#46; Adem&#225;s&#44; el estudio fue observacional y las intervenciones descritas en este documento no formaron parte de un ensayo controlado aleatorizado&#46; Por &#250;ltimo&#44; nueve pacientes &#40;9&#44;3&#37;&#41; todav&#237;a estaban en la UCI el 6 de mayo de 2020&#46; Como consecuencia&#44; los datos de resultado final para estos pacientes no estaban disponibles&#46;</p><p id="par0110" class="elsevierStylePara elsevierViewall">En conclusi&#243;n&#44; los pacientes cr&#237;ticamente enfermos con COVID-19 ingresados en las UCI de Anestesiolog&#237;a de siete hospitales del Noroeste de Espa&#241;a&#44; durante el brote de marzo-abril de 2020&#44; presentaron un alto porcentaje de complicaciones&#44; principalmente infecciones y eventos tromb&#243;ticos&#46; Tuvimos una mortalidad relativamente baja del 15&#44;5&#37;&#46; Las intervenciones de cuidados cr&#237;ticos m&#225;s frecuentes consistieron en ventilaci&#243;n mec&#225;nica y ventilaci&#243;n en dec&#250;bito prono&#44; as&#237; como varios tratamientos&#44; que incluyen agentes antivirales&#44; antibi&#243;ticos&#44; corticoides y anticoagulantes&#46; Se necesitan con urgencia ensayos cl&#237;nicos aleatorizados para determinar los tratamientos m&#225;s efectivos para pacientes con COVID-19 cr&#237;ticamente enfermos&#46;</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Mensaje final</span><p id="par0115" class="elsevierStylePara elsevierViewall">En esta investigaci&#243;n prospectiva multic&#233;ntrica en pacientes cr&#237;ticos con COVID-19&#44; que requirieron ingreso en una unidad de cuidados intensivos &#40;UCI&#41;&#44; observamos que las complicaciones fueron frecuentes&#44; con una tasa de mortalidad relativamente baja&#44; del 15&#37;&#46; En una gran proporci&#243;n de nuestros pacientes utilizamos ventilaci&#243;n mec&#225;nica invasiva&#44; dec&#250;bito prono&#44; corticoides y anticoagulantes&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Financiaci&#243;n</span><p id="par0120" class="elsevierStylePara elsevierViewall">No se recibi&#243; financiaci&#243;n para la realizaci&#243;n de este estudio&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Conflicto de intereses</span><p id="par0125" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Antecedentes y objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Existe poca informaci&#243;n sobre la evoluci&#243;n&#44; complicaciones y los tratamientos recibidos por los pacientes cr&#237;ticos con COVID-19 que requieren ingreso en una unidad de cuidados intensivos &#40;UCI&#41;&#46; El objetivo de este estudio es describir la evoluci&#243;n cl&#237;nica&#44; los tratamientos utilizados&#44; las complicaciones y resultados de pacientes cr&#237;ticos COVID-19 ingresados en siete UCI de Anestesiolog&#237;a en la Regi&#243;n de Galicia durante el pico de la pandemia en marzo-abril 2020&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">M&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Entre el 21 de marzo y el 19 de abril de 2020 evaluamos a todos los pacientes cr&#237;ticos COVID-19 ingresados en las UCI de Anestesiolog&#237;a de siete hospitales en Galicia&#44; en el Noroeste de Espa&#241;a&#46; Los resultados&#44; complicaciones y los tratamientos administrados se registraron hasta el 6 de mayo de 2020&#44; fecha final del seguimiento&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Un total de 97 pacientes cr&#237;ticos COVID-19 fueron incluidos&#46; Durante su estancia en UCI&#44; 80 pacientes &#40;82&#44;5&#37;&#41; necesitaron ventilaci&#243;n mec&#225;nica&#44; y 22 pacientes &#40;22&#44;7&#37;&#41; traqueotom&#237;a&#46; El dec&#250;bito prono se us&#243; frecuentemente en pacientes intubados &#40;67&#44;5&#37;&#41; y despiertos &#40;27&#44;8&#37;&#41;&#46; Las medicaciones usadas fueron antivirales &#40;92&#44;7&#37;&#41;&#44; corticoides &#40;93&#44;8&#37;&#41;&#44; tocilizumab &#40;57&#44;7&#37;&#41;&#44; y dosis intermedias y altas de anticoagulantes &#40;83&#44;5&#37;&#41;&#46; Las complicaciones m&#225;s frecuentes fueron infecciones adquiridas en UCI &#40;52&#44;6&#37;&#41;&#44; eventos tromb&#243;ticos &#40;16&#44;5&#37;&#41;&#44; y reintubaciones &#40;9&#44;3&#37;&#41;&#46; Tras un seguimiento medio de 42 &#40;34-45&#41; d&#237;as&#44; 15 pacientes fallecieron &#40;15&#44;5&#37;&#41;&#44; 73 pacientes &#40;75&#44;2&#37;&#41; hab&#237;an sido dados de alta de UCI y nueve pacientes &#40;9&#44;3&#37;&#41; permanec&#237;an todav&#237;a en la unidad&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Un alto porcentaje de nuestros pacientes cr&#237;ticos COVID-19 requirieron ventilaci&#243;n mec&#225;nica&#44; posici&#243;n prona&#44; medicaciones antivirales&#44; corticoides y anticoagulantes&#46; Las complicaciones en UCI fueron frecuentes&#44; principalmente infecciones y eventos tromb&#243;ticos&#46; Tuvimos una mortalidad relativamente baja del 15&#44;5&#37;&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0005"
            "titulo" => "Antecedentes y objetivos"
          ]
          1 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "M&#233;todos"
          ]
          2 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Resultados"
          ]
          3 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Conclusiones"
          ]
        ]
      ]
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Background and objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">There are limited information on outcome&#44; complications and treatments of critically ill COVID-19 patients requiring admission to an intensive care unit &#40;ICU&#41;&#46; The aim of this study is to describe the clinical ICU course&#44; treatments used&#44; complications and outcomes&#44; of critically ill COVID-19 patients admitted in seven ICU in Galicia region during the 2020 March-April pandemic peak&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Between March 21 and April 19&#44; 2020&#44; we evaluated critically ill COVID-19 patients admitted to the ICU of Anesthesia of seven hospitals in Galicia&#44; northwestern Spain&#46; Outcome&#44; complications&#44; and treatments were monitored until May 6&#44; 2020&#44; the final date of follow-up&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">A total of 97 critically ill COVID-19 patients were included&#46; During ICU stay&#44; mechanical ventilation became necessary in 80 &#40;82&#46;5&#37;&#41; patients&#44; and tracheostomy in 22 &#40;22&#46;7&#37;&#41; patients&#46; Prone position was used frequently in both intubated &#40;67&#46;5&#37;&#41; and awake &#40;27&#46;8&#37;&#41; patients&#46; Medications consisted of antivirals agents &#40;92&#46;7&#37;&#41;&#44; corticosteroids &#40;93&#46;8&#37;&#41;&#44; tocilizumab &#40;57&#46;7&#37;&#41;&#44; and intermediate or high doses of anticoagulants &#40;83&#46;5&#37;&#41;&#46; The most frequent complications were ICU-acquired infection &#40;52&#46;6&#37;&#41;&#44; thrombosis events &#40;16&#46;5&#37;&#41;&#44; and reintubation &#40;9&#46;3&#37;&#41;&#46; After a median follow-up of 42 &#40;34-45&#41; days&#44; 15 patients &#40;15&#46;5&#37;&#41; deceased&#44; 73 patients &#40;75&#46;2&#37;&#41; had been discharged from ICU&#44; and nine patients &#40;9&#46;3&#37;&#41; were still in the ICU&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">A high proportion of our critically ill COVID-19 patients required mechanical ventilation&#44; prone positioning&#44; antiviral medication&#44; corticosteroids&#44; and anticoagulants&#46; ICU complications were frequent&#44; mainly infections and thrombotic events&#46; We had a relatively low mortality of 15&#44;5&#37;&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Background and objectives"
          ]
          1 => array:2 [
            "identificador" => "abst0030"
            "titulo" => "Methods"
          ]
          2 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Results"
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          3 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Conclusions"
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        "etiqueta" => "Figura 1"
        "tipo" => "MULTIMEDIAFIGURA"
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        "descripcion" => array:1 [
          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Incidencia acumulada de pacientes fallecidos o dados de alta de la UCI&#46;</p>"
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        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">UCI&#58; Unidad de Cuidados Intensivos&#59; IMC&#58; &#237;ndice de masa corporal&#59; EPOC&#58; enfermedad pulmonar obstructiva cr&#243;nica&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Los valores se muestran como n&#250;mero &#40;porcentaje&#41; o mediana &#91;rango intercuart&#237;lico&#93;&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Sexo masculino&#44; n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">5 &#40;55&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Altura&#44; cm&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">29&#44;4 &#91;27&#44;1-32&#44;8&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">29&#44;4 &#91;27&#44;9-31&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">29&#44;1 &#91;26&#44;3-33&#44;4&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">30 &#91;29&#44;3-31&#44;2&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Enfermedades previas</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hipertensi&#243;n arterial&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Dislipemia&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Diabetes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Asma&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>EPOC&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Enfermedad cardiaca&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>C&#225;ncer&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Obesidad&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Tratamientos domiciliarios</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>IECAS&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anticoagulantes&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;7&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;20&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;5&#44;5&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;45&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antiagregantes plaquetarios&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">21 &#40;21&#44;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;40&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">13 &#40;17&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;22&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#44;27&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Estatinas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">36 &#40;37&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10 &#40;66&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">22 &#40;30&#44;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;44&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;08&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Betabloqueadores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">14 &#40;14&#44;4&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6 &#40;40&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7 &#40;9&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;11&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;05&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Corticoides&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6 &#40;6&#44;2&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;20&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">3 &#40;4&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Broncodilatadores&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9 &#40;9&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;6&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;10&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Hallazgos radiol&#243;gicos</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrado localizado&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8 &#40;8&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;6&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7 &#40;9&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Infiltrado bilateral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">83 &#40;85&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;86&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#40;83&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;66&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Consolidaci&#243;n pulmonar&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;5&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;6&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Otro&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;1&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;33&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Datos de laboratorio al ingreso en UCI</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Leucocitos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;500 &#91;5&#46;600-11&#46;610&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;660 &#91;4&#46;965 -7&#46;705&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7&#46;500 &#91;5&#46;600-11&#46;540&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#46;450 &#91;12&#46;470-16&#46;040&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Linfocitos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">600 &#91;400-960&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">460 &#91;320-520&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">640 &#91;460-1000&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">370 &#91;270-960&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Prote&#237;na C-reactiva&#44; mg&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;9 &#91;10&#44;3-34&#44;7&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25 &#91;11&#44;8-43&#44;2&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14&#44;9 &#91;10&#44;5-32&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#44;8 &#91;9&#44;5-17&#44;1&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>D&#237;mero D&#44; ng&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;204 &#91;7&#46;523- 2&#46;159&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;199 &#91;649-1&#46;837&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&#46;208 &#91;763-2&#46;482&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">873 &#91;746-2&#46;151&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#44;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lactato deshidrogenasa&#44; U&#47;L&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">454 &#91;361-633&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">517 &#91;385-670&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">453 &#91;362-632&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">407 &#91;352- 536&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;9&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ferritina s&#233;rica&#44; &#956;g&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">900 &#91;579-1&#46;422&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;197 &#91;758-1&#46;350&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">894 &#91;566-1&#46;478&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">776 &#91;565-1&#46;017&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Interleucina-6&#44; pg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#91;36&#44;4-110&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">74&#44;8 &#91;42&#44;4-97&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#91;39-102&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">345 &#91;182-507&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;98&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Procalcitonina&#44; ng&#47;mL&#46;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;1 &#91;0&#44;1-0&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;2 &#91;0&#44;1-1&#44;4&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1 &#91;0&#44;1-0&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;1 &#91;0&#44;1-0&#44;3&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Procalcitonina &#8805;&#160;0&#44;05 ng&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">21 &#40;21&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7 &#40;46&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">13 &#40;17&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1 &#40;11&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleVsp" style="height:0.5px"></span></td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " colspan="6" align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Valor m&#225;ximo durante estancia en UCI</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Prote&#237;na C-reactiva&#44; mg&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">22 &#91;15&#44;4-37&#44;8&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26 &#91;20&#44;9-51&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">20&#44;3 &#91;14&#44;4-35&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">22 &#91;17&#44;1-26&#44;5&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>D&#237;mero D&#44; ng&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;959 &#91;2&#46;231-8&#46;508&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;486 &#91;5&#46;170-13&#46;714&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;456 &#91;2&#46;100-7&#46;679&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">4&#46;182 &#91;2&#46;151-13&#46;830&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lactato deshidrogenasa&#44; U&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">572 &#91;418-849&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">663 &#91;505-804&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">550 &#91;418-910&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">416 &#91;352-629&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ferritina s&#233;rica&#44; &#956;g&#47;L&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;468 &#91;840-2&#46;353&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;620 &#91;1&#46;120-2&#46;956&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;500 &#91;840-2&#46;353&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">890 &#91;623-1&#46;827&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Interleucina-6&#44; pg&#47;mL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">159 &#91;58-463&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">170 &#91;60-323&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">129 &#91;55-463&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">409 &#91;254-1&#46;869&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Procalcitonina&#44; ng&#47;mL&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Procalcitonina &#8805;&#160;0&#44;05 ng&#47;mL&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Alta de la UCI &#40;n&#160;&#61;&#160;73&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Tiempo desde inicio de s&#237;ntomas al ingreso hospitalario&#44; d&#237;as</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#91;5-10&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#91;5-9&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7 &#91;5-10&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">10 &#91;3-14&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Tiempo desde inicio de s&#237;ntomas a ingreso en UCI&#44; d&#237;as</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">10 &#91;7-12&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">9 &#91;6-11&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#91;7-12&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">17 &#91;11-17&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Puntuaci&#243;n APACHE II en el d&#237;a 1 de ingreso en UCI</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">15 &#91;12-20&#93;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#91;11-19&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">21 &#91;16-28&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">PaO</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">&#47;FiO</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">al ingreso en UCI&#44; mmHg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">128 &#91;100-170&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">111 &#91;75-141&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">130 &#91;101-170&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">115 &#91;89-168&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">PaO</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">al ingreso en UCI&#44; mmHg</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">81 &#91;68-98&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">73 &#91;59-92&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">84 &#91;70-99&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">78 &#91;69-90&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">FiO</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">al ingreso en UCI&#44; &#37;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#91;50-100&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">80 &#91;50-100&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#91;50-100&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#91;50-80&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Ingreso hospitalario y en UCI en el mismo d&#237;a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">23 &#40;23&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;40&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;20&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Estancia en UCI&#44; d&#237;as</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Co-infecci&#243;n al ingreso en UCI</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Oxigenoterapia</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Gafas nasales de alto flujo&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ventilaci&#243;n mec&#225;nica no invasiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ventilaci&#243;n mec&#225;nica invasiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Duraci&#243;n de la ventilaci&#243;n mec&#225;nica&#44; d&#237;as&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Dec&#250;bito prono del total de pacientes</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;77&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Dec&#250;bito prono en los pacientes despiertos</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">27 &#40;27&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Dec&#250;bito prono en los pacientes ventilados</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">54&#47;80 &#40;67&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Traqueotom&#237;a</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">22 &#40;22&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">10 &#40;13&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">6 &#40;66&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Traquetom&#237;a quir&#250;rgica&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16 &#40;16&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Traquetom&#237;a percut&#225;nea por dilataci&#243;n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Tiempo desde ventilaci&#243;n mec&#225;nica a la traqueotom&#237;a&#44; d&#237;as&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Oxigenaci&#243;n de membrana extracorp&#243;rea</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">Extracci&#243;n de CO</span><span class="elsevierStyleInf"><span class="elsevierStyleItalic">2</span></span><span class="elsevierStyleItalic">extracorp&#243;rea</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Lopinavir-ritonavir&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Hidroxicloroquina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Azitromicina&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Interferon B&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">4 &#40;44&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Corticoides&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">91 &#40;93&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;93&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">68 &#40;93&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;100&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Antibi&#243;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">87 &#40;89&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;86&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">67 &#40;91&#44;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">7 &#40;77&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bloqueadores neuromusculares&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">56 &#40;57&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;86&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;52&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;55&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Vasopresores&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">63 &#40;64&#44;9&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">14 &#40;93&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">42 &#40;57&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;77&#44;75&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#44;09&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anticoagulantes a dosis profil&#225;cticas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;16&#44;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;20&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">12 &#40;16&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;11&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anticoagulantes a dosis intermedias&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;39&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">5 &#40;33&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">31 &#40;42&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2 &#40;22&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#44;95&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Anticoagulantes a dosis altas&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">43 &#40;44&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">7 &#40;46&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">30 &#40;41&#44;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6 &#40;66&#44;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">7 &#40;7&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2 &#40;13&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">1 &#40;1&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">4 &#40;44&#44;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">Reintubaci&#243;n</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">9 &#40;9&#44;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">1 &#40;6&#44;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;8&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">2 &#40;22&#44;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Dec&#250;bito prono&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Ventilaci&#243;n mec&#225;nica invasiva&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Terapia de reemplazo renal&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Exitus de pacientes en UCI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pacientes todav&#237;a en UCI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Pacientes dados de alta de UCI&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Grasselli et al&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">8</span></a>&#44; <span class="elsevierStyleItalic">Lombard&#237;a</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Bhatraju et al&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">10</span></a>&#44; <span class="elsevierStyleItalic">Seattle</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Arentz et al&#46;<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">11</span></a>&#44; <span class="elsevierStyleItalic">Washington</span>&nbsp;\t\t\t\t\t\t\n
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Información del artículo
ISSN: 00349356
Idioma original: Español
DOI:10.1016/j.redar.2020.08.004
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