Biomarcadores en la artrosis: utilidad de la proteína oligomérica de la matriz cartilaginosa (COMP) y de los glucosaminoglicanos sulfatados (sGAG) en la valoración del cartílago articular

Acebes-Cachafeiro, J.C.; Calvo-Crespo, E.; Guerrero-López, R.; Herrero-Beaumont, G.

doi:10.1016/S1888-4415(04)76243-8

Información del artículo

Resumen

Bibliografía

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Estadísticas

Introducción

La determinación de los niveles de marcadores biológicos en la artrosis puede ser de gran utilidad para graduar la lesión articular y evaluar la respuesta terapéutica de agentes potencialmente condroprotectores.

Material y métodos

La limitación fundamental de los biomarcadores es su inespecificidad y la falta de estudios que demuestren su utilidad en la clínica. En este trabajo se realiza una actualización del papel de los biomarcadores en el estudio de la artrosis y se presentan los resultados de un estudio cuyo objetivo fue evaluar la utilidad de dos marcadores biológicos de degradación del cartílago: la proteína oligomérica de matriz del cartílago (COMP) y los glucosaminoglicanos sulfatados (sGAG) en la artrosis de rodilla, analizando una posible concordancia entre sus niveles en el líquido sinovial y el grado de lesión anatómica articular graduado por medio de un método artroscópico.

Resultados y conclusiones

No se encontró correlación significativa entre el grado de lesión anatómica artroscópica y los niveles de COMP en el líquido sinovial. Se observó una débil correlación inversa significativa entre los niveles de sGAG y el grado de lesión artroscópica articular.

Palabras clave:

artrosis

marcadores biológicos

proteína oligomérica de matriz del cartílago

glucosaminoglicanos sulfatados

Introduction

The determination of concentrations of biological markers in arthrosis can be very useful for grading joint lesions and evaluating therapeutic response to potential chondroprotective agents.

Materials and methods

The fundamental limitation of biomarkers is their lack of specificity and the absence of studies demonstrating their usefulness in clinical practice. The role of biomarkers in the evaluation of osteoarthritis is examined. The results of a study of the utility of two biological markers of cartilage breakdown in knee cartilage oligomeric matrix protein (COMP) and sulfate glycosaminoglycans (sGAG), is reported. The possible concordance between biomarker levels in synovial fluid and anatomic lesions graded arthroscopically was analyzed.

Results and conclusions

No significant correlation was found between the arthroscopic lesion grade and COMP levels in synovial fluid. There was a significant, but weak, inverse correlation between sGAG levels and arthroscopic articular lesion grade.

Key words:

osteoarthritis

biological markers

cartilage oligomeric matrix protein

sulfate gycosaminoglycans

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