metricas
covid
Buscar en
Revista Española de Geriatría y Gerontología
Toda la web
Inicio Revista Española de Geriatría y Gerontología La anosognosia en la enfermedad de Alzheimer
Información de la revista
Vol. 42. Núm. 3.
Páginas 181-187 (mayo 2007)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 42. Núm. 3.
Páginas 181-187 (mayo 2007)
Revisión
Acceso a texto completo
La anosognosia en la enfermedad de Alzheimer
Anosognosia in alzheimer's disease
Visitas
19793
Eva M. Arroyo-Anllóa,
Autor para correspondencia
anlloa@usal.es

Correspondencia: Dra. E.M. Arroyo Anlló. Clínica de la Memoria de Daño Cerebral. C/ Reyes Católicos, 1-9. 37002 Salamanca. España.
, Clara Gil Méndezb
a Facultad de Psicología. Universidad de Salamanca. Instituto de Neurociencias de Castilla-León. Clínica de Memoria de Daño Cerebral de Salamanca. Salamanca. España
b Facultad de Psicología. Universidad Pontificia de Salamanca. Salamanca. España
Este artículo ha recibido
Información del artículo
Resumen
Bibliografía
Descargar PDF
Estadísticas
Resumen

La anosognosia es un trastorno común, multifactorial y de naturaleza compleja tras daño cerebral, donde los pacientes no son conscientes de su trastorno.

En este artículo, revisamos la anosognosia en la enfermedad de Alzheimer (EA).

La anosognosia en la EA es considerada como una faceta multidi-mensional. Se han propuesto varias teorías que pretenden explicar la no toma de consciencia de los déficits neurológicos o cognitivos, como las teorías neuroanatómicas, neurológicas o psicopatológicas. La anosognosia en la EA es frecuente. Numerosos estudios encuentran una correlación significativa entre la gravedad de la demencia y lesiones en el hemisferio cerebral derecho o una disfunción de tipo frontal, pero se dan resultados contradictorios.

Palabras clave:
Anosognosia
Demencia
Consciencia
Alzheimer
Síndrome frontal
Abstract

Anosognosia is a common, multifactorial, complex disorder after brain damage, in which patients remain unaware of their disability. To review data on anosognosia in Alzheimer's disease (AD). Anosognosia in la AD is considered to be multidimensional. Several theoretical frameworks, such as neuroanatomic, neurological or psychopathological theories, aim to explain the lack of unawareness of neurological or cognitive impairment.

Anosognosia is frequent in AD. Many studies have found a significant correlation between the severity of dementia and right hemisphere damages or frontal dysfunction, but the results are contradictory.

Key words:
Anosognosia
Dementia
Awareness
Alzheimer
Frontal syndrome
El Texto completo está disponible en PDF
Bibliografía
[1.]
G.P. Prigatano, D.L. Schacter.
Awareness of deficit after brain injury: Clinical and Theoretical Issues.
Oxford University Press, (1991),
[2.]
P. Vuilleumier.
Anosognosia.
Behavior and Mood Disorders in Focal Brain Lesions, pp. 465-519
[3.]
P. Vuilleumier.
Anosognosia: The neurology of beliefs and uncertainties.
Cortex, 40 (2004), pp. 9-17
[4.]
A.J. Marcel, R. Tegner, I. Nimmo-Smith.
Anosognosia for plegia: Specificity, extension, partiality and disunity of unawareness.
Cortex, 40 (2004), pp. 17-38
[5.]
A.J. Marcel, C. Dobel.
Structured perceptual input imposes an egocentric frame of reference-pointing, imagery, and spatial self-consciousness.
Perception, 34 (2005), pp. 638-660
[6.]
J. Babinski.
Contribution à l’étude des troubles mentaux dans l’hémiplégie organique (anosognosie).
Rev Neurol, 27 (1914), pp. 845-848
[7.]
G. Anton.
Ueber die Selbstwahrnehmung der Herderkrankubgen des Gehirns durch den Kranden bei Rindenbeleiheit und Rindentaubheit.
Arch Psychiatr Nervenkr, 32 (1899), pp. 86-127
[8.]
S.M. McGlynn, A.W. Kaszniak.
Unawareness of deficits in dementia and schizophrenia.
Awareness of deficit after brain injury: Clinical and theoretical issues,
[9.]
A.B. Rubens, M.F. Garrett.
Anosognosia of linguistic deficits in patients with neurological deficits.
Awareness of deficit after brain injury: Clinical and Theoretical Issues, pp. 40-47
[10.]
B. Pillon, B. Dubois, Y. Agid.
Cognitive deficits in non-Alzheimer's degenerative diseases.
J Neural Transm, 47 (1996), pp. 61-71
[11.]
D.T. Stuss.
Disturbance of self-awareness after frontal system damage.
Awareness of deficit after brain injury: Clinical and Theoretical Issues, pp. 57-63
[12.]
S.M. McGlynn, A.W. Kaszniak.
When metacognition fails: impaired awareness of deficit in Alzhiemer's disease.
J Cogn Neurosci, 3 (1991), pp. 183-189
[13.]
D.L. Schacter.
Unawareness of deficit and unawareness of knowledge in patients with memory disorders.
Awareness of deficit after brain injury: Clinical and Theoretical Issues, pp. 48-56
[14.]
D.N. Levine, R. Calvanio, W.E. Rinn.
The pathogenesis of anosognosia for hemiplegia.
Neurology, 41 (1991), pp. 1770-1781
[15.]
K. Goldstein.
Language and language disturbances.
Grune & Stratton, (1948),
[16.]
G. Gainotti.
Emotional behavior and hemispheric side of the lesion.
Cortex, 8 (1972), pp. 41-55
[17.]
S.E. Starkstein, M.L. Berthier, P. Fedoroff, T.R. Price, R.G. Robinson.
Anosognosia and major depression in 2 patients with cerebrovascular lesions.
Neurology, 40 (1990), pp. 1380-1382
[18.]
S.E. Starkstein, J.P. Fedoroff, T.R. Price, R. Leiguarda, R.G. Robinson.
Anosognosia in patients with cerebrovascular lesions. A study of causative factors.
Stroke, 23 (1992), pp. 1446-1453
[19.]
F. Ghika-Schmid, G. Van Melle, P. Guex, J. Bogousslavsky.
Subjective experience and behavior in acute stroke: The Lausanne Emotion in Acute Stroke Study.
Neurology, 52 (1999), pp. 22-28
[20.]
S.E. Starkstein, P. Fedoroff, T.R. Prcie, R. Leiguarda, R.G. Robinson.
Neuropsychological deficits in patients with anosognosia.
Neuropsychiatry Neuropsychol Behav Neurol, 6 (1993), pp. 43-48
[21.]
N. Geschwind.
Disconnexion syndromes in animals and man.
Brain, 88 (1965), pp. 237-294
[22.]
L. Pia, M. Neppi-Modona, R. Ricci, A. Berti.
The anatomy for anosognosia for hemiplegia: A meta-analysis.
Cortex, 40 (2004), pp. 367-377
[23.]
A. Donoso.
Anosognosia en enfermedades cerebrales.
Rev Chil Neuropsiquiatr, 4 (2002), pp. 69-79
[24.]
A. Venneri, M.F. Shanks.
Belief and awareness: reflections on a case of persistent anosognosia.
Neuropsychologia, 42 (2004), pp. 230-238
[25.]
J. Cutting.
Study of anosognosia.
J Neurol Neurosurg Psychiatry, 41 (1978), pp. 548-555
[26.]
D.M. Heilman.
Anosognosia: Possible neuropsychological mechanisms.
Awareness of deficit after brain injury: Clinical and Theoretical Issues, pp. 53-62
[27.]
E. Daprati, A. Sirigu, P. Pradat-Diehl, N. Franck, M. Jeannerod.
Recognition for self-produced movement in a case of severe neglect.
Neurocase, 158 (2000), pp. 427-430
[28.]
J.C. Addair, R.E.L. Schwartz, D.L. Na, E. Fennel, R.L. Gilmore, K.M. Heilman.
Anosognosia: Examining the disconnection hypothesis.
J Neurol Neurosurg Psychiatry, 63 (1997), pp. 798-800
[29.]
R. Bisiach, G. Vallar, D. Perani, C. Papagno, A. Berti.
Unawareness of disease following lesions of the right hemisphere: Anosognosia for hemiplegia and anososgnosia for hemianopsia.
Neuropsychologia, 24 (1986), pp. 471-482
[30.]
R. Garcin, A. Varay, H. Dimo.
Document pour servir à l’ètude des troubles du schéma corporel.
Rev Neurol, 69 (1938), pp. 498-510
[31.]
M. Small, S. Ellis.
Denial of hemiplegia: An investigation into the theories of causation.
Eur Neurol, 36 (1996), pp. 353-363
[32.]
D.N. Levine.
Unawareness of visual and sensorimotor defects: A hypothesis.
Brain Cogn, 13 (1990), pp. 233-281
[33.]
V. Dauriac-Le Masson, L. Mailhan, A. Louis-Dreyfus, G. De Montety, P. Denys, B. Bussel, P. Azouvi.
Double dissociation between unilateral neglect and anosognosia.
Rev Neurol, 158 (2002), pp. 427-430
[34.]
R. Bisiach, A. Berti.
Dyschiria: An attempt at its systemic explanation.
Neuropsysiological and neuropsychological aspects of spatial neglect, pp. 183-201
[35.]
E.A. Weinstein, R.L. Kahn.
Denial of Illness: symbolic and physiological aspects.
Charles C. Thomas, (1955),
[36.]
G. Dalla Barba, V. Parlato, A. Iavarone, F. Boller.
Anosognosia, intrusions and frontal functions in Alzheimer's disease and depression.
Neuropsychologia, 2 (1995), pp. 247-259
[37.]
L. Clarc, B.A.C.G. Wilson, I. Roth, J.R. Hodges.
Assessing awareness in earlystage Alzheimer's disease: Development and piloting of the Memory awareness rating scale.
Neuropsychol Rehabil, 1 2 (2002), pp. 341-362
[38.]
O.L. López, J.T. Becker, D. Somsak, M.A. Dew, S.T. Dekosky.
Awareness of cognitive deficits and anosognosia in probable Alzheimer's disease.
Eur J Neurol, 34 (1994), pp. 277-282
[39.]
B.R. Reed, W.J. Jagust, L. Coulter.
Anosognosia in Alzheimer's disease: relationships to depression, cognitive function, and cerebral perfusion.
J Clin Exp Neuropsychol, 15 (1993), pp. 231-244
[40.]
J.J. Vasterling, B. Seltzer, W.E. Watrous.
Longitudinal assessment of deficit unawareness in Alzheimer's disease.
Neuropsychiatry Neuropsychol Behav Neurol, 10 (1997), pp. 197-202
[41.]
A. Michon, B. Deweer, B. Pillon, Y. Agid, B. Dubois.
Relation of anosognosia to frontal lobe dysfunction in Alzheimer's disease.
J Neurol Neurosurg Psychiatry, 57 (1994), pp. 805-809
[42.]
S. Katz, A.B. Ford, R.W. Moskowitz, B.A. Jackson, M.W. Jaffe.
Studies of illness in the aged: the index of ADL, a standardized measure of biological and psychological function.
J Am Med Assoc, 185 (1963), pp. 914-919
[43.]
M.P. Lawton, E.M. Brody.
Assessment of older people: Self-maintaining and instrumental activities of daily living.
Gerontologist, 9 (1969), pp. 179-186
[44.]
D.M. McNair, E.J. Kahn.
Self assessment of cognitive deficits.
Assessment in geriatric psychopharmacology, pp. 137-143
[45.]
L.R. Squire, J.A. Zouzounis.
Self-ratings of memory dysfunction: different findings in depression and amnesia.
J Clin Exp Neuropsychol, 10 (1988), pp. 727-738
[46.]
M.M. Swanberg, R.E. Tractenberg, R. Mohs, L.J. Thal, J.L. Cummings.
Executive dysfunction in Alzheimer disease.
Arch Neurol, 61 (2004), pp. 556-560
[47.]
J.L. Cummings, J.A. Chung.
Alteraciones neuropsiquiátricas en la enfermedad de Alzheimer.
Alzheimer XXI: Ciencia y Sociedad, pp. 285-298
[48.]
R. Alberca.
Manifestaciones clínicas de la enfermedad de Alzheimer.
Enfermedad de Alzheimer y otras demencias, 2.ª ed., pp. 233-250
[49.]
C.A. Smith, V.W. Henderson, C.A. McCleary, G.A. Murdock, J.G. Buckwalter.
Anosognosia and Alzheimer's disease: the role of depressive symptoms in mediating impaired insight.
J Clin Exp Neuropsychol, 22 (2000), pp. 437-444
[50.]
O.P. Almeida, E.I. Crocco.
Percepçao dos déficits cognitivos e alteraçoes do comportamento em pacientes com doença de Alzheimer.
Arq Neuropsiquiatr, 58 (2000), pp. 2A
[51.]
S.E. Starkstein, L. Sabe, S. Vazquez, A. Teson, G. Petracca, E. Chemerinski, et al.
Neuropsychological, psychiatric, and cerebral blood flow findings in vascular dementia and Alzheimer's disease.
Stroke, 27 (1996), pp. 408-414
[52.]
A.P. Auchus, J.L. Woodard, F.C. Goldstein, J. Green, R.C. Green.
Anosognosia in Alzheimer's disease.
Arch Neurol, 53 (1996), pp. 10
[53.]
C. Hazif-Thomas, P. Thomas, E.M. Arroyo-Anlló.
Anosognosie et hallucinations.
Hallucinations et maladies neuro-dégéneratives, pp. 19-31
[54.]
R. Allegri, F. Taragano, M. Feldman, P. Harris, C. Naglè.
Relación entre las quejas subjetivas de memoria y el reporte familiar en pacientes con demencia tipo Alzheimer.
Actas Esp Psiquiatr, 28 (2000), pp. 373-378
[55.]
A. Vogel, J. Sotkholm, A. Gade, B. Bo Andersen, A. Hejl.
Awareness of deficits in mild cognitive impairment and Alzheimer's disease: Do MCI patients have impaired insight?.
Dement Geriatr Cogn Disord, 17 (2004), pp. 181-187
[56.]
C. Carr.
Locating an error correction signal for adult birdsong.
Nat Neurosci, 3 (2000), pp. 419-421
[57.]
E.M. Arroyo-Anlló, R. Gil, M. Rosier, L. Barraquer i Bordás.
Aprendizajes procedimentales y enfermedades neurológicas.
Rev Neurol, 29 (1999), pp. 1246-1267
[58.]
E.M. Arroyo-Anlló.
Estimulación psico-cognoscitiva en las demencias. Programas de talleres de estimulación.
Prous Science, (2002),
[59.]
M. Leonni-Stanonik, J.H. Dougherty, C.A. Licata, et al.
Anosognosia in mild Alzheimer's disease: revelations by FDG-PET.
EurJ Neurol, 9 (2002), pp. 42
[60.]
R. Trouillet, M.C. Gely-Nargeot, C. Derouesné.
La méconnaissance des troubles dans la maladie d’Alzheimer: nécessité d’une approche multidimensionnelle.
Psychologie & NeuroPsychiatrie du Vieillissement, 1 (2004), pp. 99-110
[61.]
R. Migliorelli, A. Tesón, L. Sabe, M. Petracchi, R. Leiguarda, S. Starkstein.
Prevalence and correlates of dysthymia and mayor depression among patients with Alzheimer's Disease.
Am J Psychiatry, 152 (1995), pp. 37-44
[62.]
S.E. Starkstein, L. Sabe, G. Petracca, E. Chemerinski, G. Kuzis, M. Merello, et al.
Neuropsychological and psychiatric differences between Alzheimer's disease and Parkinson's disease with dementia.
J Neurol Neurosurg Psychiatry, 61 (1996), pp. 381-387
[63.]
S. Kotler-Cope, C.J. Camp.
Anosognosia in Alzheimer disease.
Alzheimer Dis Assoc Disord, 9 (1995), pp. 52-56
[64.]
A. Vogel, S.G. Hasselbalch, A. Gade, M. Ziebell, G. Waldemar.
Cognitive and functional neuroimaging correlate for anosognosia in mild cognitive impairment and Alzheimer's disease.
International J Geriatr Psychiatry, 20 (2005), pp. 238-246
[65.]
R. Gil, E.M. Arroyo-Anlló, P. Ingrand, M. Gil, J.P. Neau, C. Ornon, et al.
Selfconsciousness and Alzheimer's disease.
Acta Neurol Scand, 104 (2001), pp. 296-300
[66.]
C.A. Mangone, D.B. Hier, P.B. Gorelick, R.J. Ganellen, P. Langenberg, R. Boarman, et al.
Impaired insight in Alzheimer's disease.
J Geriatr Psychiatry Neurol, 4 (1991), pp. 189-193
[67.]
S.E. Starkstein, L. Sabe, A.G. Cuerva, G. Kuzis, R. Leiguarda.
Anosognosia and procedural learning in Alzheimer's disease.
Neuropsychiatry Neuropsychol Behav Neurol, 10 (1997), pp. 96-101
[68.]
D.G. Harwood, D.L. Sultzer, M.A. Wheatley.
Impaired insight in Alzheimer's disease: Association with cognitive deficits, psychiatric symptoms and behavioural disturbances.
Neuropsychiatry Neuropsychol Behav Neurol, 13 (2000), pp. 83-88
[69.]
S. Sevush, N. Leve, A. Brickman.
Age at disease onset and pattern of cognitive impairment in probable Alzheimer's disease.
J Neuropsychiatry Clin Neurosci, 5 (1993), pp. 66-72
[70.]
B.R. Ott, G. Lafleche, W.M. Whelihan, G.W. Buongiorno, M.S. Albert, B.S. Fogel.
Impaired awareness of deficits in Alzheimer disease.
Alzheimer Dis Assoc Disord, 10 (1996), pp. 68-76
[71.]
S.E. Starkstein, S. Vazquez, R. Migliorelli, A. Teson, L. Sabe, R. Leiguarda.
A single-photon emission computed tomographic study of anosognosia in Alzheimer's disease.
Arch Neurol, 52 (1995), pp. 415-420
[72.]
G.A. Marshall, D.I. Kaufer, O.L. Lopez, G.R. Rao, R.L. Hamilton, S.T. DeKosky.
Rightprosubiculumamyloid plaque density correlates with anosognosia in Alzheimer's disease.
J Neurol Neurosurg Psychiatry, 75 (2004), pp. 1396-1400
[73.]
A.R. Damasio.
La sensación de lo que ocurre: cuerpo y emoción en la construcción de la consciencia.
Debate, (2001),
[74.]
A.R. Damasio.
Mental self. The person within.
Nature, 423 (2003), pp. 227
[75.]
E.A. Weinstein, R.L. Kahn.
Personality factors in denial of illness.
Arch Neurol Psychiatry, 69 (1953), pp. 355-367
[76.]
J.S. Snowden, D. Craufurd, H.L. Griffiths, D. Neary.
Awareness of involuntary movements in Huntington disease.
Arch Neurol, 55 (1998), pp. 801-805
Copyright © 2007. Sociedad Española de Geriatría y Gerontología
Descargar PDF
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos

Quizás le interese:
10.1016/j.regg.2024.101492
No mostrar más