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Kumar, V.S. Dhull, S. Karunanithi, C. Bal, R. Kumar" "autores" => array:5 [ 0 => array:2 [ "nombre" => "G." "apellidos" => "Kumar" ] 1 => array:2 [ "nombre" => "V.S." "apellidos" => "Dhull" ] 2 => array:2 [ "nombre" => "S." "apellidos" => "Karunanithi" ] 3 => array:2 [ "nombre" => "C." "apellidos" => "Bal" ] 4 => array:4 [ "nombre" => "R." "apellidos" => "Kumar" "email" => array:1 [ 0 => "rkphulia@yahoo.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "<span class="elsevierStyleSup">68</span>Ga-DOTANOC PET/TC scan imitando dinámica renal: Falta de captación fisiológica en el bazo y la hipófisis de un recién nacido en el hiperinsulinismo congénito" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1840 "Ancho" => 3285 "Tamanyo" => 314812 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">68</span>Ga-DOTANOC maximum intensity projection PET images revealed the physiological excretion of the radiotracer through kidneys, ureters and bladder; thus mimicking a renal dynamic scan (A). Transaxial CT and PET/CT images of pituitary gland (B, C) and spleen (D, E), which revealed no significant physiological <span class="elsevierStyleSup">68</span>Ga-DOTANOC uptake. Also, no abnormal uptake was noted in the pancreas (A).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We present a case of 25-day-old neonate who presented with recurrent and persistent hypoglycemia refractory to medical treatment. At 22<span class="elsevierStyleHsp" style=""></span>h of life, the baby developed hypoglycemia (22<span class="elsevierStyleHsp" style=""></span>mg/dl), put on glucose infusion rate (GIR) of 6<span class="elsevierStyleHsp" style=""></span>mg/kg/min gradually increased to 12<span class="elsevierStyleHsp" style=""></span>mg/kg/min. In view of persistent hypoglycemia, hydrocortisone 5<span class="elsevierStyleHsp" style=""></span>mg/kg/day was started on day 3. The baby gradually required GIR of 24<span class="elsevierStyleHsp" style=""></span>mg/kg/min and multiple drugs (octreotide 25 mcg/kg/min, chlorthiazide 7.5<span class="elsevierStyleHsp" style=""></span>mg/kg/day, diazoxide 20<span class="elsevierStyleHsp" style=""></span>mg/kg/day and hydrocortisone 10<span class="elsevierStyleHsp" style=""></span>mg/kg/day). Critical sample of the baby showed hyperinsulinism (10.11<span class="elsevierStyleHsp" style=""></span>μU/ml), cortisol and C peptide were normal. The baby was maintaining sugar on multiple drugs on day 15 and all drugs were gradually reduced over a period of 10 days and is now on diazoxide 5<span class="elsevierStyleHsp" style=""></span>mg/kg/day only. In view of persistent hypoglycemia refractory to medical treatment, the baby was referred for <span class="elsevierStyleSup">68</span>Ga-labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI3-octreotide (DOTANOC) positron emission tomography/computed tomography (PET/CT) to localize the lesion. <span class="elsevierStyleSup">68</span>Ga-DOTANOC PET/CT showed the physiological excretion of the radiotracer through kidneys, ureters and bladder; thus mimicking a renal dynamic scan (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). No significant physiological <span class="elsevierStyleSup">68</span>Ga-DOTANOC uptake was noted in spleen or pituitary (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B–E). Also, no abnormal uptake was noted in the pancreas.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">In congenital hyperinsulinism of infancy (CHI), the pre-operative differentiation of focal from diffuse form is important from management point of view. Although, <span class="elsevierStyleSup">18</span>F-fluoro-DOPA PET imaging is the norm, somatostatin receptor (SSTR) imaging has also been used. Five subtypes of SSTR (SSTR 1–5) have been discovered. <span class="elsevierStyleSup">68</span>Ga-DOTANOC is an octreotide-based radiopharmaceutical which carries a high affinity particularly for SSTR 2 and 5.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The physiologic uptake of <span class="elsevierStyleSup">68</span>Ga-DOTANOC in spleen is due to higher expression of SSTR 2 (particularly SSTR 2a) mRNA in spleen which gradually increases with age.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Fetal pituitary expresses SSTR 2 as early as 16 weeks of fetal life but the developmental pattern of expression varies considerably.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The uptake in the pancreas appeared very diffuse and mild to be considered significant (SUVmax pancreas<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.85; SUVmax liver<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.96). Although immunohistochemical analysis of human pancreatic tissue sections has revealed that SSTR2 is the main type present in both β-cells and α-cells, but the exact age of maturation is not known.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> Therefore, present case highlights the fact that the physiological distribution of <span class="elsevierStyleSup">68</span>Ga-DOTANOC can differ in early life due to incomplete/immature expression of the SSTR and has to be kept in mind while reporting such cases. Future studies are warranted to substantiate the incomplete/immature expression of the SSTR in early life.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0015" class="elsevierStylePara elsevierViewall">No funding received from any organization for this study.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0020" class="elsevierStylePara elsevierViewall">The authors declare that there is no conflict of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2013-09-30" "fechaAceptado" => "2013-12-05" "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1840 "Ancho" => 3285 "Tamanyo" => 314812 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">68</span>Ga-DOTANOC maximum intensity projection PET images revealed the physiological excretion of the radiotracer through kidneys, ureters and bladder; thus mimicking a renal dynamic scan (A). Transaxial CT and PET/CT images of pituitary gland (B, C) and spleen (D, E), which revealed no significant physiological <span class="elsevierStyleSup">68</span>Ga-DOTANOC uptake. Also, no abnormal uptake was noted in the pancreas (A).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:4 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Novel use of somatostatin receptor scintigraphy in localization of focal congenital hyperinsulinism: promising but fallible" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Dutta" 1 => "S. Venkataseshan" 2 => "C. Bal" 3 => "K.L. Rao" 4 => "K. Gupta" 5 => "A. 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68Ga-DOTANOC PET/CT mimicking renal dynamic scan: Lack of physiological uptake in the spleen of a newborn and the pituitary gland in congenital hyperinsulinism
68Ga-DOTANOC PET/TC scan imitando dinámica renal: Falta de captación fisiológica en el bazo y la hipófisis de un recién nacido en el hiperinsulinismo congénito
G. Kumar, V.S. Dhull, S. Karunanithi, C. Bal, R. Kumar
Autor para correspondencia
Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India