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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Introducci&#243;n</span><p id="par0005" class="elsevierStylePara elsevierViewall">El c&#225;ncer de pr&#243;stata es el segundo tumor maligno m&#225;s frecuente en el hombre y una de las enfermedades malignas m&#225;s frecuentes del mundo<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">1</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">La detecci&#243;n de lesiones vinculadas a una recurrencia de c&#225;ncer de pr&#243;stata en el contexto de una reca&#237;da bioqu&#237;mica &#40;RBQ&#41; constituye un reto importante para todas las modalidades de im&#225;genes<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">La PET&#47;TC con radiof&#225;rmacos derivados de la colina ha encontrado un amplio uso para el diagn&#243;stico de recidiva de c&#225;ncer de pr&#243;stata en pacientes con RBQ&#46; Sin embargo&#44; se han publicado numerosos estudios demostrando valores de sensibilidad y especificidad relativamente bajos&#44; especialmente a niveles bajos de PSA<a class="elsevierStyleCrossRefs" href="#bib0165"><span class="elsevierStyleSup">3&#44;4</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">En pacientes con c&#225;ncer de pr&#243;stata avanzado&#44; a pesar del &#233;xito terap&#233;utico de las estrategias iniciales&#44; la mayor&#237;a se hacen independientes a los andr&#243;genos y progresan con niveles elevados de ant&#237;geno prost&#225;tico espec&#237;fico &#40;PSA&#41; bajo terap&#233;uticas de supresi&#243;n hormonal&#46; El c&#225;ncer de pr&#243;stata hormonorresistente se define por la progresi&#243;n de la enfermedad a pesar de la terapia de privaci&#243;n de andr&#243;genos&#46; Este evento es un desaf&#237;o cl&#237;nico&#44; ya que el poder del tratamiento para pacientes con c&#225;ncer de pr&#243;stata hormonorresistente con met&#225;stasis a distancia es muy limitado&#46; Son necesarias urgentemente nuevas estrategias terap&#233;uticas capaces de controlar la evoluci&#243;n de la enfermedad en este estadio de la enfermedad<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">5</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Una serie de investigaciones evaluaron la posible diferenciaci&#243;n neuroendocrina &#40;DNE&#41; de las c&#233;lulas de c&#225;ncer de pr&#243;stata en la fase de resistencia a la castraci&#243;n<a class="elsevierStyleCrossRefs" href="#bib0180"><span class="elsevierStyleSup">6&#8211;8</span></a>&#46; La DNE ha recibido especial atenci&#243;n en los &#250;ltimos a&#241;os por las implicaciones pron&#243;sticas y terap&#233;uticas&#44; dada la progresi&#243;n de la enfermedad a pesar de los tratamientos convencionales<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">7</span></a>&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">La DNE se caracteriza por grupos dispersos de c&#233;lulas neuroendocrinas diferenciadas entre una poblaci&#243;n predominante de c&#233;lulas de adenocarcinoma y tiene potencial pron&#243;stico y terap&#233;utico en el c&#225;ncer de pr&#243;stata<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a>&#46; La DNE ha sido asociada con hasta el 85&#37; de pacientes con c&#225;ncer de pr&#243;stata hormonorresistente<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a>&#46; La hiperactivaci&#243;n celular neuroendocrina puede jugar un papel clave en la patog&#233;nesis del c&#225;ncer de pr&#243;stata resistente a la castraci&#243;n a trav&#233;s de la producci&#243;n y secreci&#243;n de neurop&#233;ptidos bioactivos<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a>&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Existen c&#233;lulas neuroendocrinas en la pr&#243;stata normal que forman una red de comunicaci&#243;n vinculada con la regulaci&#243;n de la proliferaci&#243;n celular<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a> y que son independientes de la estimulaci&#243;n androg&#233;nica<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a>&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">Estas c&#233;lulas expresan receptores de la somatostatina &#40;SSTR&#41; y pueden ser identificadas con an&#225;logos de la somatostatina marcados con <span class="elsevierStyleSup">68</span>Ga &#40;<span class="elsevierStyleSup">68</span>Ga-DOTA-p&#233;ptidos&#41; que constituyen trazadores PET alternativos y atractivos para la evaluaci&#243;n de pacientes con c&#225;ncer de pr&#243;stata hormonorresistentes<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">6</span></a>&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">Diversos trabajos han estudiado la sobreexpresi&#243;n de los SSTR en diferentes tumores sobre todo neuroendocrinos<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">11</span></a> y tambi&#233;n en pacientes con c&#225;ncer de pr&#243;stata&#44; mediante <span class="elsevierStyleSup">68</span>Ga-DOTA-p&#233;ptidos<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">12&#44;13</span></a>&#46;</p><p id="par0050" class="elsevierStylePara elsevierViewall">A este respecto se ha demostrado que algunas lesiones de c&#225;ncer de pr&#243;stata pueden ser visibles con estos radiotrazadores mediante PET&#47;TC confirmando la expresi&#243;n de estos receptores<a class="elsevierStyleCrossRefs" href="#bib0220"><span class="elsevierStyleSup">14&#44;15</span></a>&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">Esto motiv&#243; la realizaci&#243;n por parte de nuestro grupo de estudios preliminares usando el <span class="elsevierStyleSup">68</span>Ga-DOTATATE PET&#47;TC en una peque&#241;a serie de pacientes con c&#225;ncer de pr&#243;stata avanzado en RBQ&#46; Se pudo visualizar con esta t&#233;cnica todas las lesiones previamente detectadas por gammagraf&#237;a &#243;sea y&#44; adicionalmente&#44; lesiones prost&#225;ticas y ganglionares p&#233;lvicas<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">16</span></a>&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">Recientemente&#44; las terapias de combinaci&#243;n con an&#225;logos de la somatostatina han surgido como posibles opciones terap&#233;uticas para los pacientes con c&#225;ncer de pr&#243;stata avanzado andr&#243;geno independiente&#44; mediante el uso de radiof&#225;rmacos emisores de part&#237;culas &#946;- como <span class="elsevierStyleSup">90</span>Y o <span class="elsevierStyleSup">177</span>Lu para radioterapia<a class="elsevierStyleCrossRef" href="#bib0190"><span class="elsevierStyleSup">8</span></a>&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">Es de relevancia cl&#237;nica la cuidadosa determinaci&#243;n de la presencia de c&#233;lulas neuroendocrinas en el c&#225;ncer de pr&#243;stata&#44; con la identificaci&#243;n de subgrupos de potenciales respondedores a estas terapias<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a>&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">Por lo tanto&#44; el objetivo de este estudio fue comparar prospectivamente la tasa de detecci&#243;n de la PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE versus la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina en pacientes con c&#225;ncer de pr&#243;stata en reca&#237;da bioqu&#237;mica y evaluar in vivo la expresi&#243;n de receptores de la somatostatina con el fin de planificar eventuales terapias dirigidas contra estos blancos moleculares&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Material y m&#233;todos</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Pacientes</span><p id="par0075" class="elsevierStylePara elsevierViewall">Analizamos prospectivamente 64 pacientes con RBQ seg&#250;n los criterios internacionales aceptados&#44; remitidos a nuestro servicio entre marzo de 2012 y enero de 2014&#46; Las caracter&#237;sticas de los pacientes se resumen en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46; Cuarenta y dos pacientes &#40;65&#37;&#41; hab&#237;an sido sometidos a prostatectom&#237;a radical y 22 pacientes fueron tratados con radioterapia &#40;asociada o no a terapia de deprivaci&#243;n hormonal&#41;&#46; La edad promedio fue de 64&#44;98 &#177; 7&#44;03 a&#241;os&#46; La mediana del nivel de PSA fue de 4&#44;25 ng&#47;mL&#44; oscilando entre 0&#44;22 y 291 ng&#47;mL&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Consideraciones &#233;ticas</span><p id="par0080" class="elsevierStylePara elsevierViewall">El estudio fue aprobado por el Comit&#233; de &#201;tica de nuestro Centro y llevado a cabo de acuerdo con la Declaraci&#243;n de Helsinki&#44; con sus respectivas enmiendas posteriores&#44; y con los requisitos de la ICMJE&#46; Adem&#225;s&#44; se obtuvieron los consentimientos informados de todos los participantes incluidos en el estudio y la autorizaci&#243;n para la publicaci&#243;n de los resultados de forma an&#243;nima&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Radiof&#225;rmacos</span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090"><span class="elsevierStyleSup">11</span>C-colina</span><p id="par0085" class="elsevierStylePara elsevierViewall">En un m&#243;dulo autom&#225;tico se desarroll&#243; la s&#237;ntesis de &#91;N-metil-<span class="elsevierStyleSup">11</span>C&#93; colina a partir de <span class="elsevierStyleSup">11</span>CO2 y dimetilaminoetanol&#46;</p><p id="par0090" class="elsevierStylePara elsevierViewall">La reacci&#243;n y purificaci&#243;n se efectu&#243; en un Sep-PakAccell Plus CM &#40;Millipore&#41;&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">La pureza radioqu&#237;mica de la <span class="elsevierStyleSup">11</span>C-colina fue mayor al 95&#37;&#46;</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095"><span class="elsevierStyleSup">68</span>Ga-DOTATATE</span><p id="par0100" class="elsevierStylePara elsevierViewall">Se obtuvo la eluci&#243;n de un generador de <span class="elsevierStyleSup">68</span>Ge&#47;<span class="elsevierStyleSup">68</span>Ga &#40;ITG&#44; Alemania&#41;&#46;</p><p id="par0105" class="elsevierStylePara elsevierViewall">Se efectu&#243; un calentamiento durante 10 min a 100<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; pH 3&#46;5-4&#46;2&#44; siendo la cantidad de p&#233;ptido de 20 nmoles o menos&#46; Se purific&#243; el marcado por SPEC &#40;SepPak C 18 light&#41; eluyendo con ETOH 30&#37; y formulando con NACL 0&#44;9&#37;&#44; determinando posteriormente la pureza radionucle&#237;dica y radioqu&#237;mica del <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46;</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Adquisici&#243;n de im&#225;genes</span><p id="par0110" class="elsevierStylePara elsevierViewall">No se requiri&#243; de ayuno ni de la suspensi&#243;n de la medicaci&#243;n habitual&#46;</p><p id="par0115" class="elsevierStylePara elsevierViewall">La preparaci&#243;n del paciente incluy&#243; la colocaci&#243;n de un v&#237;a intravenosa y la hidrataci&#243;n con 500<span class="elsevierStyleHsp" style=""></span>ml de soluci&#243;n salina al 0&#44;9&#37;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">En un intervalo no mayor a 2 semanas se realizaron dos estudios PET&#47;TC&#58; uno con <span class="elsevierStyleSup">11</span>C-colina y otro con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#44; siendo indistinto el orden de ejecuci&#243;n y el posterior an&#225;lisis de los mismos&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">Los estudios fueron adquiridos en un equipo PET&#47;TC de 64 cortes &#40;General Electric Discovery 690 VCT&#44; 64 cortes&#44; Waukesha&#44; WI&#44; EE&#46; UU&#46;&#41; inmediatamente despu&#233;s de la inyecci&#243;n de 6&#44;0 MBq&#47;kg de <span class="elsevierStyleSup">11</span>C-colina o 30 min despu&#233;s de la administraci&#243;n intravenosa de 2&#44;0 MBq&#47;kg de <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46;</p><p id="par0130" class="elsevierStylePara elsevierViewall">Se adquirieron im&#225;genes desde cr&#225;neo hasta la mitad de muslo&#46; La adquisici&#243;n y los par&#225;metros de procesamiento de las im&#225;genes de PET fueron los mismos para la <span class="elsevierStyleSup">11</span>C-colina y para el <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46;</p><p id="par0135" class="elsevierStylePara elsevierViewall">La tomograf&#237;a computada se realiz&#243; con 80-180<span class="elsevierStyleHsp" style=""></span>mA&#44; 120 Kv &#40;&#171;index noise&#187; 30&#41; y 3&#44;75<span class="elsevierStyleHsp" style=""></span>mm de espesor de corte&#44; pitch de 1&#46;375&#44; tiempo de rotaci&#243;n de 0&#44;8 segundos y movimiento de tabla de 55<span class="elsevierStyleHsp" style=""></span>mm&#47;rotaci&#243;n&#46;</p><p id="par0140" class="elsevierStylePara elsevierViewall">Se adquiri&#243; una PET en modo 3D&#44; tama&#241;o de la matriz de 128 &#215; 128 pixeles&#44; con tiempo de adquisici&#243;n de 3 o 4 min por cada posici&#243;n de cama &#40;<span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE respectivamente&#41;&#44; con superposici&#243;n de corte de 11<span class="elsevierStyleHsp" style=""></span>mm&#46;</p><p id="par0145" class="elsevierStylePara elsevierViewall">Las im&#225;genes fueron reconstruidas mediante un algoritmo de reconstrucci&#243;n iterativa OSEM &#40;Ordered Subset Expectation Maximization&#41; con 28 subconjuntos&#47;2 iteraciones&#44; con correcci&#243;n por &#171;tiempo de vuelo&#187; y reformadas en cortes transversales&#44; coronales y sagitales&#46;</p><p id="par0150" class="elsevierStylePara elsevierViewall">Las im&#225;genes fueron evaluadas en conjunto por dos especialistas en medicina nuclear y por dos m&#233;dicos radi&#243;logos&#46; Ambos juegos de im&#225;genes se evaluaron conjuntamente&#46; Los desacuerdos fueron resueltos por consenso&#46;</p><p id="par0155" class="elsevierStylePara elsevierViewall">Todas las lesiones que se consideraron visualmente como malignas se contaron y se analizaron con respecto a su localizaci&#243;n &#40;recidiva local&#44; met&#225;stasis &#243;seas&#44; ganglionares o de partes blandas&#41; y al valor de captaci&#243;n m&#225;ximo estandarizado &#40;SUVm&#225;x&#41;&#46;</p><p id="par0160" class="elsevierStylePara elsevierViewall">Las lesiones sospechosas fueron definidas como cualquier captaci&#243;n focal&#44; en una o m&#225;s localizaciones&#44; de mayor intensidad que la captaci&#243;n de fondo o background circundante o en comparaci&#243;n con el tejido normal&#44; excluyendo zonas articulares y &#225;reas de captaci&#243;n fisiol&#243;gica&#46;</p><p id="par0165" class="elsevierStylePara elsevierViewall">El patr&#243;n de comparaci&#243;n a considerar fue alguno de los siguientes&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">1&#41;</span><p id="par0170" class="elsevierStylePara elsevierViewall">Anatom&#237;a patol&#243;gica de las lesiones mediante estudio histol&#243;gico&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">2&#41;</span><p id="par0175" class="elsevierStylePara elsevierViewall">Comparaci&#243;n de los hallazgos de la PET&#47;TC con otras t&#233;cnicas de imagen&#58; tomograf&#237;a computarizada con contraste intravenoso&#44; resonancia magn&#233;tica&#44; gammagraf&#237;a &#243;sea&#44; ecograf&#237;a transrectal&#44; o nuevos estudios PET&#47;TC&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">3&#41;</span><p id="par0180" class="elsevierStylePara elsevierViewall">Seguimiento bioqu&#237;mico y cl&#237;nico del paciente&#44; por un per&#237;odo superior a 6 meses despu&#233;s de realizados los estudios PET&#47;TC&#46; Para ello&#44; se revisaron historias cl&#237;nicas y entrevistaron telef&#243;nicamente a los pacientes y&#47;o a los m&#233;dicos tratantes&#46;</p></li></ul></p><p id="par0185" class="elsevierStylePara elsevierViewall">Los hallazgos PET&#47;TC se consideraron cl&#237;nicamente verdaderos positivos si se dieron una o m&#225;s de las siguientes circunstancias&#58;<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">1&#41;</span><p id="par0190" class="elsevierStylePara elsevierViewall">Confirmaci&#243;n histopatol&#243;gica&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">2&#41;</span><p id="par0195" class="elsevierStylePara elsevierViewall">Confirmaci&#243;n de la lesi&#243;n por resultados concordantes con otras t&#233;cnicas de imagen ya sea en la reevaluaci&#243;n de estudios previos o en estudios posteriores&#46;</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">3&#41;</span><p id="par0200" class="elsevierStylePara elsevierViewall">Confirmaci&#243;n de la lesi&#243;n en estudios PET&#47;TC posteriores&#44; con aumento de tama&#241;o&#47;captaci&#243;n de <span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE y&#47;o aparici&#243;n de nuevas lesiones&#46;</p></li><li class="elsevierStyleListItem" id="lsti0035"><span class="elsevierStyleLabel">4&#41;</span><p id="par0205" class="elsevierStylePara elsevierViewall">Descenso mayor del 50&#37; de los valores de PSA en pacientes tratados posteriormente a la realizaci&#243;n de los estudios PET&#47;TC&#46;</p></li><li class="elsevierStyleListItem" id="lsti0040"><span class="elsevierStyleLabel">5&#41;</span><p id="par0210" class="elsevierStylePara elsevierViewall">Persistencia y empeoramiento de los s&#237;ntomas y&#47;o niveles en ascenso de PSA&#46;</p></li></ul></p><p id="par0215" class="elsevierStylePara elsevierViewall">Se consideraron como cl&#237;nicamente verdaderos negativos&#44; a aquellos pacientes que mostraron una estabilizaci&#243;n duradera en el tiempo &#40;&#62; 6 meses&#41; o normalizaci&#243;n espont&#225;nea de los valores de PSA durante el seguimiento&#44; sin aparici&#243;n de lesiones en otros estudios de imagen o PET&#47;TC de control&#46;</p><p id="par0220" class="elsevierStylePara elsevierViewall">El an&#225;lisis de las im&#225;genes se realiz&#243; utilizando una plataforma General Electric AW 4&#46;6 &#40;HP Workstation y LINUX OS&#41; y OsiriX v6&#46;5&#46;2 &#40;OS X El Capitan&#41;&#46;</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">An&#225;lisis estad&#237;stico</span><p id="par0225" class="elsevierStylePara elsevierViewall">Los valores de SUVm&#225;x de las mismas lesiones detectadas con ambos trazadores&#44; <span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#44; se analizaron estad&#237;sticamente utilizando un an&#225;lisis de Wilcoxon para datos apareados &#40;Wilcoxon-Signed test&#41;&#46;</p><p id="par0230" class="elsevierStylePara elsevierViewall">Se evalu&#243; la normalidad de ambos trazadores por separado&#44; gr&#225;ficamente y mediante un test de normalidad &#40;test de Shapiro-Wilk&#41;&#46;</p><p id="par0235" class="elsevierStylePara elsevierViewall">Se realiz&#243; una correlaci&#243;n entre valores de SUVm&#225;x de <span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE para lesiones concordantes utilizando un coeficiente de correlaci&#243;n no param&#233;trico &#40;rho de Spearman&#41;&#46;</p><p id="par0240" class="elsevierStylePara elsevierViewall">Se determin&#243; la tasa de detecci&#243;n de los trazadores <span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE en diversos puntos de corte de PSA&#46;</p><p id="par0245" class="elsevierStylePara elsevierViewall">Se valor&#243; la relaci&#243;n entre PSA y SUVm&#225;x para ambas investigaciones&#46;</p><p id="par0250" class="elsevierStylePara elsevierViewall">En todos los an&#225;lisis se consider&#243; un nivel de significaci&#243;n &#945; &#61; 0&#44;05&#46;</p><p id="par0255" class="elsevierStylePara elsevierViewall">Para los an&#225;lisis estad&#237;sticos se utiliz&#243; el GraphPad Prism &#40;versi&#243;n 7&#46;00 para Mac OS X&#44; La Jolla&#44; CA&#44; EE&#46; UU&#41;&#44; el software R versi&#243;n 3&#46;2&#46;2 &#40;-R Core Team &#40;2015&#41;&#46; R&#58; A language and environment for statistical computing&#46; R Foundation for Statistical Computing&#44; Vienna&#44; Austria&#46; URL <a id="intr0005" class="elsevierStyleInterRef" href="https://www.r-project.org/">https&#58;&#47;&#47;www&#46;R-project&#46;org&#47;</a>&#46;&#41; y el RStudioversi&#243;n 0&#46;99&#46;485 &#40;RStudio Team &#40;2015&#41;&#46; RStudio&#58; Integrated Development for R&#46; RStudio&#44; Inc&#46;&#44; Boston&#44; MA URL <a id="intr0010" class="elsevierStyleInterRef" href="http://www.rstudio.com/">http&#58;&#47;&#47;www&#46;rstudio&#46;com&#47;</a>&#41;&#46;</p></span></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Resultados</span><p id="par0260" class="elsevierStylePara elsevierViewall">La tasa de detecci&#243;n global por paciente fue del 48&#44;43&#37; &#40;31&#47;64&#41; para <span class="elsevierStyleSup">68</span>Ga-DOTATATE y de 46&#44;87&#37; &#40;30&#47;64&#41; para <span class="elsevierStyleSup">11</span>C-colina&#46;</p><p id="par0265" class="elsevierStylePara elsevierViewall">Ambas t&#233;cnicas fueron positivas en 25 pacientes &#40;39&#37;&#41; y negativas en 28 pacientes &#40;43&#44;70&#37;&#41;&#46; Seis pacientes fueron positivos &#250;nicamente con <span class="elsevierStyleSup">68</span>Ga-DOTATATE &#40;9&#44;4&#37;&#41; y 5 &#250;nicamente con <span class="elsevierStyleSup">11</span>C-colina &#40;7&#44;8&#37;&#41;&#46; Los resultados fueron concordantes en 53 casos &#40;82&#44;81&#37;&#41; &#40;<a class="elsevierStyleCrossRefs" href="#fig0005">figs&#46; 1 y 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><p id="par0270" class="elsevierStylePara elsevierViewall">Un total de 215 lesiones fueron detectadas con al menos un radiotrazador&#58; 149 para <span class="elsevierStyleSup">68</span>Ga-DOTATATE y 197 para <span class="elsevierStyleSup">11</span>C-colina&#46; La localizaci&#243;n de las lesiones para cada trazador se describe en la <a class="elsevierStyleCrossRef" href="#tbl0005">tabla 1</a>&#46;</p><p id="par0275" class="elsevierStylePara elsevierViewall">Se evalu&#243; la normalidad de ambos trazadores por separado&#44; gr&#225;ficamente y mediante un test de normalidad&#46; Ninguna de las dos medidas tiene distribuci&#243;n normal &#40;test de Shapiro-Wilk&#44; valor-p &#60; 0&#44;0001&#41;&#46;</p><p id="par0280" class="elsevierStylePara elsevierViewall">Se valor&#243; adem&#225;s la capacidad de detecci&#243;n de enfermedad de la PET&#47;TC &#40;positividad de la prueba&#41; en funci&#243;n de distintos valores del PSA&#58; 1 ng&#47;mL&#44; 4&#44;25 ng&#47;mL y 5 ng&#47;mL &#40;4&#44;25 ng&#47;mL corresponde a la mediana de la distribuci&#243;n de PSA observada en la muestra de pacientes y los otros dos valores corresponden a valores de inter&#233;s cl&#237;nico obtenidos de bibliograf&#237;a&#41;&#46;</p><p id="par0285" class="elsevierStylePara elsevierViewall">As&#237;&#44; con un PSA menor a 1 ng&#47;mL se detectan captaciones patol&#243;gicas en un 6&#37; de los pacientes con <span class="elsevierStyleSup">11</span>C-colina y en un 12&#37; de los pacientes con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46; Con valores entre 1 y 5 ng&#47;mL los porcentajes de detecci&#243;n se elevaban hasta el 54&#37; y 36&#37; respectivamente&#46; Finalmente&#44; se alcanzaron porcentajes del 72&#37; y 80&#37; &#40;<span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE respectivamente&#41; con valores de PSA igual o superiores a 5 ng&#47;mL&#46;</p><p id="par0290" class="elsevierStylePara elsevierViewall">Para la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina&#44; con valores de PSA menores o iguales a 4&#44;25 ng&#47;mL &#40;mediana muestral&#41; se identific&#243; al menos una lesi&#243;n caracter&#237;stica para c&#225;ncer de pr&#243;stata en 25&#37; de los pacientes&#44; mientras que 65&#44;75&#37; de los pacientes presentaron lesiones patol&#243;gicas con valores de PSA superiores a 4&#44;25 ng&#47;mL&#46;</p><p id="par0295" class="elsevierStylePara elsevierViewall">Usando el mismo umbral para la PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#44; el 21&#44;8&#37; de los pacientes se present&#243; con al menos una lesi&#243;n con un nivel de PSA de 4&#44;25 ng&#47;mL y menos&#46; Adem&#225;s&#44; el 75&#37; de los pacientes presentaron lesiones patol&#243;gicas con valores de PSA superiores a 4&#44;25 ng&#47;mL&#46;</p><p id="par0300" class="elsevierStylePara elsevierViewall">El SUV m&#225;ximo de la <span class="elsevierStyleSup">11</span>C-colina fue significativamente mayor que el correspondiente al <span class="elsevierStyleSup">68</span>Ga-DOTATATE para todas las lesiones concordantes &#40;n &#61; 130&#41;&#58; 6&#44;17 &#40;1&#44;70-15&#44;50&#41; versus 4&#44;38 &#40;1&#44;37-26&#44;70&#41;&#44; mediana &#40;rango&#41;&#44; para cada radiotrazador&#44; respectivamente &#40;p &#60; 0&#44;0001&#41;&#46;</p><p id="par0305" class="elsevierStylePara elsevierViewall">Se encontr&#243; una correlaci&#243;n significativa entre el SUVm&#225;x de ambos trazadores &#40;r &#61; 0&#44;41&#44; n &#61; 130&#44; p &#60;0&#44;0001&#41;&#46;</p><p id="par0310" class="elsevierStylePara elsevierViewall">Los valores por paciente de sensibilidad y especificidad&#44; con sus intervalos de confianza del 95&#37; fueron los mismos para ambas t&#233;cnicas&#58; 0&#44;82 &#40;0&#44;65 a 0&#44;93&#41; y 0&#44;90 &#40;0&#44;73-0&#44;98&#41;&#44; respectivamente&#46;</p><p id="par0315" class="elsevierStylePara elsevierViewall">En el grupo de pacientes con PSA &#60; 4&#44;25 la sensibilidad calculada fue de 0&#44;63&#44; mientras que los pacientes con PSA &#62; 4&#44;25 presentaron una sensibilidad de 0&#44;89&#44; mismos valores para ambas t&#233;cnicas&#46;</p><p id="par0320" class="elsevierStylePara elsevierViewall">No se encontr&#243; relaci&#243;n entre el SUVm&#225;x de ambos radiotrazadores&#44; con el tipo de lesi&#243;n detectada ni con el nivel de PSA&#46;</p><p id="par0325" class="elsevierStylePara elsevierViewall">Del total de la poblaci&#243;n&#44; &#250;nicamente cuatro pacientes con resultados positivos fueron operados y la anatom&#237;a patol&#243;gica de los mismos revel&#243; alteraciones inflamatorias&#46;</p><p id="par0330" class="elsevierStylePara elsevierViewall">La comparaci&#243;n de la captaci&#243;n de <span class="elsevierStyleSup">11</span>C-colina con la correspondiente al <span class="elsevierStyleSup">68</span>Ga-DOTATATE permitir&#237;a identificar lesiones malignas con expresi&#243;n de receptores de la somatostatina que podr&#237;an constituir un blanco espec&#237;fico prometedor para la terapia mediante <span class="elsevierStyleSup">177</span>Lu-DOTATATE&#46; Si bien existe alta coincidencia entre ambas t&#233;cnicas&#44; parece existir superioridad en el nivel de captaci&#243;n y n&#250;mero de lesiones detectadas con <span class="elsevierStyleSup">11</span>C-colina&#46;</p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Discusi&#243;n</span><p id="par0335" class="elsevierStylePara elsevierViewall">Despu&#233;s de aplicar un tratamiento con intenci&#243;n curativa por c&#225;ncer de pr&#243;stata cl&#237;nicamente localizado con cirug&#237;a o radioterapia&#44; 15-30&#37; de los pacientes evidencia progresi&#243;n bioqu&#237;mica&#44; que precede a una recurrencia cl&#237;nicamente detectable a nivel p&#233;lvico o enfermedad metast&#225;sica en un plazo de meses o a&#241;os<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">17</span></a>&#46;</p><p id="par0340" class="elsevierStylePara elsevierViewall">La utilidad de la PET&#47;TC con colina radiomarcada en la evaluaci&#243;n de estos pacientes ha sido ampliamente demostrada en varios estudios cl&#237;nicos<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">18</span></a> que han confirmado una captaci&#243;n preferencial por el c&#225;ncer de pr&#243;stata&#44; los ganglios linf&#225;ticos y sus met&#225;stasis<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">19</span></a>&#46; Sin embargo&#44; la colina no es espec&#237;fica para el c&#225;ncer de pr&#243;stata&#44; tanto en la enfermedad intra- como extraprost&#225;tica&#44; y adem&#225;s una alta afinidad del radiof&#225;rmaco se ha evidenciado por la hiperplasia prost&#225;tica benigna&#46; Como consecuencia&#44; la discriminaci&#243;n entre tejido intraprost&#225;tico benigno y maligno se ve obstaculizada por una baja especificidad<a class="elsevierStyleCrossRef" href="#bib0250"><span class="elsevierStyleSup">20</span></a>&#46; Adem&#225;s&#44; la sensibilidad de la PET&#47;TC con colina en la detecci&#243;n del c&#225;ncer de pr&#243;stata localmente recurrente es baja&#44; especialmente en el caso de valores bajos de PSA<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">21&#44;22</span></a>&#46;</p><p id="par0345" class="elsevierStylePara elsevierViewall">Por otro lado&#44; la PET&#47;TC con receptores de la somatostatina emplea trazadores <span class="elsevierStyleSup">68</span>Ga-DOTA-p&#233;ptidos &#40;DOTA-TOC&#44; DOTA-TATE&#44; DOTA-NOC&#41; que se unen espec&#237;ficamente a estos receptores<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">12&#8211;14</span></a>&#46; La diferencia m&#225;s relevante entre los diversos compuestos es la afinidad de uni&#243;n variable para los distintos subtipos de receptores<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">15</span></a>&#46; Existen 5 subtipos &#40;1-5&#41;&#59; 2A y 2B son los m&#225;s com&#250;nmente expresados en las c&#233;lulas NE &#40;95&#37;&#41;<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a>&#46; Ha sido reportada la sobreexpresi&#243;n del SSTR2 en pacientes con c&#225;ncer de pr&#243;stata recurrente<a class="elsevierStyleCrossRef" href="#bib0270"><span class="elsevierStyleSup">24</span></a>&#46;</p><p id="par0350" class="elsevierStylePara elsevierViewall">Por lo tanto&#44; es de valor cl&#237;nico la confirmaci&#243;n de un n&#250;mero suficiente de SSTR con el fin de planificar una terapia dirigida contra estos blancos moleculares mediante el marcaje con is&#243;topos emisores de part&#237;culas &#946;- como <span class="elsevierStyleSup">90</span>Y o <span class="elsevierStyleSup">177</span>Lu&#44; logrando un procedimiento combinado con potencial de permitir un abordaje terap&#233;utico basado en las im&#225;genes moleculares &#40;&#171;theranostics&#187; o &#171;diagnoterapia&#187;&#41;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">8&#44;16&#44;25</span></a>&#46;</p><p id="par0355" class="elsevierStylePara elsevierViewall">Analizamos prospectivamente 64 pacientes en RBQ despu&#233;s de tratamiento convencional de su c&#225;ncer de pr&#243;stata&#46; En un intervalo no mayor a 2 semanas se realizaron dos estudios PET&#47;TC&#58; uno con <span class="elsevierStyleSup">11</span>C-colina y otro con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46;</p><p id="par0360" class="elsevierStylePara elsevierViewall">En un 48&#44;43&#37; de los pacientes se encontraron hallazgos patol&#243;gicos en la PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46; Esto coincide con los datos de la literatura&#44; en donde se demuestra captaci&#243;n de trazadores an&#225;logos de la somatostatina en diversos tipos de tumores que expresan estos receptores<a class="elsevierStyleCrossRefs" href="#bib0215"><span class="elsevierStyleSup">13&#44;16&#44;26</span></a>&#46;</p><p id="par0365" class="elsevierStylePara elsevierViewall">Por otro lado en un 46&#44;87&#37; de los pacientes se detect&#243; al menos una lesi&#243;n caracter&#237;stica de c&#225;ncer de pr&#243;stata en la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina&#44; similar tambi&#233;n a lo reportado en la literatura<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">4&#44;5</span></a>&#46;</p><p id="par0370" class="elsevierStylePara elsevierViewall">Ambas t&#233;cnicas fueron positivas en 25 pacientes &#40;39&#37;&#41; y negativas en 28 pacientes &#40;43&#44;70&#37;&#41;&#46; Seis pacientes fueron positivos &#250;nicamente con <span class="elsevierStyleSup">68</span>Ga-DOTATATE &#40;9&#44;4&#37;&#41; y 5 &#250;nicamente con <span class="elsevierStyleSup">11</span>C-colina &#40;7&#44;8&#37;&#41;&#46; Los resultados fueron concordantes en 53 casos &#40;82&#44;81&#37;&#41;&#46;</p><p id="par0375" class="elsevierStylePara elsevierViewall">En la actualidad persiste controversia sobre la eficiencia de la <span class="elsevierStyleSup">11</span>C-colina en diferentes puntos de corte de PSA y diversos autores establecen valores de entre 1 y 5 ng&#47;mL como discriminador de estudios PET positivos o negativos<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">21&#44;22&#44;27&#44;28</span></a>&#46;</p><p id="par0380" class="elsevierStylePara elsevierViewall">En nuestro estudio se valor&#243; la capacidad de detecci&#243;n de enfermedad de la PET&#47;TC &#40;positividad de la prueba&#41; en funci&#243;n de los valores del PSA&#44; observando una relaci&#243;n entre ambos par&#225;metros&#46; As&#237;&#44; con un PSA menor a 1 ng&#47;mL se detectan captaciones patol&#243;gicas en un 6&#37; de los pacientes con <span class="elsevierStyleSup">11</span>C-colina y en un 12&#37; de los pacientes con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46; Con valores entre 1 y 5 ng&#47;mL los porcentajes de detecci&#243;n se elevaban hasta el 54&#37; y 36&#37; respectivamente&#46; Finalmente&#44; se alcanzaron porcentajes del 72&#37; y 80&#37; &#40;<span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE respectivamente&#41; con valores de PSA igual o superiores a 5 ng&#47;mL&#46;</p><p id="par0385" class="elsevierStylePara elsevierViewall">Para la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina&#44; con valores de PSA menores o iguales a 4&#44;25 ng&#47;mL &#40;mediana muestral&#41; se identific&#243; al menos una lesi&#243;n caracter&#237;stica para c&#225;ncer de pr&#243;stata en 25&#37; de los pacientes&#44; mientras que 65&#44;75&#37; de los pacientes presentaron lesiones patol&#243;gicas con valores de PSA superiores a 4&#44;25 ng&#47;mL&#46; Nuestros resultados fueron similares a los informados en la literatura<a class="elsevierStyleCrossRefs" href="#bib0170"><span class="elsevierStyleSup">4&#44;5&#44;18&#44;21&#44;22&#44;27&#44;28</span></a>&#46;</p><p id="par0390" class="elsevierStylePara elsevierViewall">Usando el mismo umbral para el <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#44; el 21&#44;8&#37; de los pacientes present&#243; al menos una lesi&#243;n con un nivel de PSA de 4&#44;25 ng&#47;mL o inferior&#46; Adem&#225;s&#44; el 75&#37; de los pacientes presentaron lesiones patol&#243;gicas con valores de PSA superiores a 4&#44;25 ng&#47;mL&#46;</p><p id="par0395" class="elsevierStylePara elsevierViewall">Si bien hay trabajos en la literatura que estudian los valores de SUVm&#225;x de los <span class="elsevierStyleSup">68</span>Ga-DOTA-p&#233;ptidos en pacientes con tumores neuroendocrinos<a class="elsevierStyleCrossRef" href="#bib0265"><span class="elsevierStyleSup">23</span></a>&#44; no existen trabajos que lo relacionen con el nivel de PSA en pacientes con c&#225;ncer de pr&#243;stata&#46;</p><p id="par0400" class="elsevierStylePara elsevierViewall">Nuestro estudio demuestra que la tasa de detecci&#243;n del c&#225;ncer de pr&#243;stata recurrente y sus met&#225;stasis mejora conforme la elevaci&#243;n del marcador tumoral&#46; Esto coincide ampliamente con los datos reportados en la literatura<a class="elsevierStyleCrossRefs" href="#bib0255"><span class="elsevierStyleSup">21&#44;27&#44;28</span></a>&#46;</p><p id="par0405" class="elsevierStylePara elsevierViewall">Adem&#225;s&#44; se realiz&#243; una correlaci&#243;n entre valores de SUVm&#225;x de <span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATE utilizando un coeficiente de correlaci&#243;n no param&#233;trico &#40;rho de Spearman&#41; y se demostr&#243; una correlaci&#243;n estad&#237;sticamente significativa&#44; aunque d&#233;bil entre ambas &#40;r &#61; 0&#44;41&#44; n &#61; 130&#44; p &#60; 0&#44;0001&#41;&#46;</p><p id="par0410" class="elsevierStylePara elsevierViewall">Sin embargo&#44; se demostr&#243; que la <span class="elsevierStyleSup">11</span>C-colina detect&#243; mayor cantidad de lesiones con respecto al <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46;</p><p id="par0415" class="elsevierStylePara elsevierViewall">El SUVm&#225;x de la <span class="elsevierStyleSup">11</span>C-colina fue significativamente mayor que el correspondiente al <span class="elsevierStyleSup">68</span>Ga-DOTATATE para todas las lesiones concordantes &#40;n &#61; 130&#41;&#58; 6&#44;17 &#40;1&#44;70-15&#44;50&#41; y 4&#44;38 &#40;1&#44;37-26&#44;70&#41;&#44; p &#60; 0&#44;0001&#59; mediana &#40;rango&#41;&#44; respectivamente&#46;</p><p id="par0420" class="elsevierStylePara elsevierViewall">Nuestros resultados fueron similares a los informados en la literatura<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">11&#44;13&#8211;15&#44;23&#44;24</span></a>&#46;</p><p id="par0425" class="elsevierStylePara elsevierViewall">Los valores por paciente de sensibilidad y especificidad&#44; con sus intervalos de confianza del 95&#37; fueron los mismos para ambas t&#233;cnicas&#58; 0&#44;82 &#40;0&#44;65 a 0&#44;93&#41; y 0&#44;90 &#40;0&#44;73-0&#44;98&#41;&#44; respectivamente&#46;</p><p id="par0430" class="elsevierStylePara elsevierViewall">Aunque se observ&#243; una tendencia hacia una menor sensibilidad para pacientes con niveles de PSA inferiores&#44; la diferencia no fue estad&#237;sticamente significativa&#58; 0&#44;63 vs&#46; 0&#44;89&#59; p &#61; 0&#44;13&#59; mismos valores para ambos trazadores&#44; para pacientes con PSA &#60; 4&#44;25 y &#8805; 4&#44;25 ng&#47;mL&#44; respectivamente&#46; Esto puede estar influenciado por el tama&#241;o de la muestra y en el hecho de que la mayor&#237;a de los pacientes presentaban valores de PSA elevados&#44; lo que constituy&#243; una limitaci&#243;n en el estudio&#46; Desafortunadamente&#44; nuestro estudio no incluy&#243; suficientes pacientes con valores de PSA m&#225;s bajos&#46;</p><p id="par0435" class="elsevierStylePara elsevierViewall">Se han documentado algunos resultados discordantes &#40;<a class="elsevierStyleCrossRef" href="#fig0010">fig&#46; 2</a>&#41;&#46; La diferente captaci&#243;n entre los radiotrazadores puede ser debida a diversidad de factores&#44; como por ejemplo terapias previas&#44; la influencia del tratamiento antiandrog&#233;nico&#44; diferentes variables histol&#243;gicas del c&#225;ncer de pr&#243;stata&#44; caracter&#237;sticas biol&#243;gicas diferentes como la expresi&#243;n de receptores de la somatostatina o los transportadores de colina o tumoral entre otros&#46;</p><p id="par0440" class="elsevierStylePara elsevierViewall">Cuatro pacientes con resultados PET&#47;TC positivos fueron operados &#40;a los pacientes n&#250;mero 7&#44; 32 y 46 se les inform&#243; ganglios positivos&#44; y al paciente n&#250;mero 19 se le inform&#243; de captaci&#243;n en lecho prost&#225;tico&#41; y la anatom&#237;a patol&#243;gica de los mismos revel&#243; alteraciones inflamatorias &#40;<a class="elsevierStyleCrossRefs" href="#fig0015">figs&#46; 3 y 4</a>&#41;&#46;</p><elsevierMultimedia ident="fig0015"></elsevierMultimedia><elsevierMultimedia ident="fig0020"></elsevierMultimedia><p id="par0445" class="elsevierStylePara elsevierViewall">Se ha visto que los receptores de la somatostatina se expresan tambi&#233;n en los macr&#243;fagos que juegan un rol en los procesos inflamatorios y que adem&#225;s se puede encontrar un aumento en la actividad colinquinasa de estas c&#233;lulas cuando son activadas&#46;</p><p id="par0450" class="elsevierStylePara elsevierViewall">La captaci&#243;n de <span class="elsevierStyleSup">11</span>C-colina y <span class="elsevierStyleSup">68</span>Ga-DOTATATE en procesos inflamatorios o infecciosos&#44; puede limitar la especificidad de estas t&#233;cnicas para la detecci&#243;n de enfermedad metast&#225;sica oculta y debe ser tomada en cuenta a la hora de decidir maniobras invasivas<a class="elsevierStyleCrossRef" href="#bib0295"><span class="elsevierStyleSup">29</span></a>&#46;</p><p id="par0455" class="elsevierStylePara elsevierViewall">Esto motiv&#243; una publicaci&#243;n por parte de nuestro grupo informando de los posibles falsos positivos de estas t&#233;cnicas<a class="elsevierStyleCrossRef" href="#bib0300"><span class="elsevierStyleSup">30</span></a>&#46;</p><p id="par0460" class="elsevierStylePara elsevierViewall">En esta serie de pacientes se demuestra que tanto la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina como con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#44; mediante diferentes mecanismos&#44; poseen capacidad de detecci&#243;n de lesiones patol&#243;gicas en el estudio de recidivas bioqu&#237;micas ocultas del carcinoma de pr&#243;stata&#44; y esto parece ser dependiente del nivel del PSA&#46;</p><p id="par0465" class="elsevierStylePara elsevierViewall">El <span class="elsevierStyleSup">68</span>Ga-DOTATATE como aplicaci&#243;n diagn&#243;stica busca identificar receptores de la somatostatina en el c&#225;ncer de pr&#243;stata&#46; Como aplicaci&#243;n terap&#233;utica ser&#237;a posible el marcaje de los mismos an&#225;logos de la somatostatina con radiois&#243;topos beta negativos &#40;<span class="elsevierStyleSup">177</span>Lutecio&#41; con la finalidad de irradiar en forma espec&#237;fica estas c&#233;lulas tumorales<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">10</span></a>&#46; La terapia con <span class="elsevierStyleSup">177</span>Lu-DOTATATE puede ser efectiva en aquellos pacientes con c&#225;ncer de pr&#243;stata hormonorresistente que no poseen otras opciones terap&#233;uticas y se demuestra una captaci&#243;n suficiente de <span class="elsevierStyleSup">68</span>Ga-DOTATATE en las lesiones tumorales observadas en la PET&#47;TC&#46;</p><p id="par0470" class="elsevierStylePara elsevierViewall">Dado que existe alta coincidencia entre ambas t&#233;cnicas &#40;aunque con superioridad en el nivel de captaci&#243;n y n&#250;mero de lesiones detectadas con <span class="elsevierStyleSup">11</span>C-colina&#41; creemos que ser&#237;a factible la terapia radioguiada en estos pacientes&#46;</p><p id="par0475" class="elsevierStylePara elsevierViewall">En este trabajo la adquisici&#243;n de las im&#225;genes se realiz&#243; 30 min postinyecci&#243;n del <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46; Diversos trabajos adquieren las im&#225;genes 45 a 60 min postinyecci&#243;n&#46; Ser&#237;a de inter&#233;s valorar si el tiempo de adquisici&#243;n influye en los resultados&#46;</p><p id="par0480" class="elsevierStylePara elsevierViewall">Nuestro estudio tiene limitaciones&#46; Hubiera sido deseable correlacionar el valor de Gleason con los resultados ya que est&#225; descrito que la diferenciaci&#243;n neuroendocrina parece relacionarse con la agresividad<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">9</span></a>&#46; Tampoco disponemos de datos de marcadores de tumores espec&#237;ficos de tumores neuroendocrinos como la cromogranina A en nuestros pacientes&#46;</p><p id="par0485" class="elsevierStylePara elsevierViewall">Finalmente&#44; hubi&#233;ramos deseado haber podido realizar estudios dirigidos histol&#243;gicos de las lesiones para conocer el verdadero significado de la captaci&#243;n del <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46;</p></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Conclusiones</span><p id="par0490" class="elsevierStylePara elsevierViewall">La PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE y la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina parecen poseer alta capacidad de detecci&#243;n de lesiones patol&#243;gicas en la evaluaci&#243;n de los pacientes con c&#225;ncer de pr&#243;stata en reca&#237;da bioqu&#237;mica&#46;</p><p id="par0495" class="elsevierStylePara elsevierViewall">Se necesitan m&#225;s estudios con el fin de probar el posible valor cl&#237;nico complementario de estas t&#233;cnicas PET&#47;TC&#44; y para el <span class="elsevierStyleSup">68</span>Ga-DOTATATE para la potencial planificaci&#243;n de terapias mediadas por los receptores de somatostatina &#40;<span class="elsevierStyleSup">177</span>Lu-DOTATATE&#41;&#46;</p></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Autor&#237;a&#47;colaboradores</span><p id="par0500" class="elsevierStylePara elsevierViewall">Todos los autores han hecho contribuciones en cada uno de los siguientes aspectos&#58; 1&#41; la concepci&#243;n y el dise&#241;o del estudio&#44; la adquisici&#243;n de datos&#44; el an&#225;lisis y la interpretaci&#243;n de los datos&#44; 2&#41; el borrador del art&#237;culo y la revisi&#243;n cr&#237;tica del contenido intelectual&#44; y 3&#41; la aprobaci&#243;n definitiva de la versi&#243;n que se presenta&#46;</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0130">Conflicto de intereses</span><p id="par0505" class="elsevierStylePara elsevierViewall">Los autores declaran no tener ning&#250;n conflicto de intereses&#46;</p></span></span>"
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          "titulo" => "Abstract"
          "secciones" => array:4 [
            0 => array:2 [
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              "titulo" => "Background and objectives"
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            1 => array:2 [
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              "titulo" => "Material and methods"
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              "titulo" => "Consideraciones &#233;ticas"
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              "titulo" => "Radiof&#225;rmacos"
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                  "titulo" => "C-colina"
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              "titulo" => "Adquisici&#243;n de im&#225;genes"
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              "titulo" => "An&#225;lisis estad&#237;stico"
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          "titulo" => "Conclusiones"
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          "titulo" => "Autor&#237;a&#47;colaboradores"
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          "titulo" => "Conflicto de intereses"
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    "fechaRecibido" => "2018-03-16"
    "fechaAceptado" => "2018-08-30"
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          "palabras" => array:6 [
            0 => "C&#225;ncer de pr&#243;stata"
            1 => "Reca&#237;da bioqu&#237;mica"
            2 => "PET&#47;TC"
            3 => "<span class="elsevierStyleSup">11</span>C-colina"
            4 => "<span class="elsevierStyleSup">68</span>Ga-DOTATATE"
            5 => "Receptores de la somatostatina"
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          "clase" => "keyword"
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            0 => "Prostate cancer"
            1 => "Biochemical relapse"
            2 => "PET&#47;CT"
            3 => "<span class="elsevierStyleSup">11</span>C-choline"
            4 => "<span class="elsevierStyleSup">68</span>Ga-DOTATATE"
            5 => "Somostatin receptors"
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    "resumen" => array:2 [
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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Antecedentes y objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Comparar prospectivamente la tasa de detecci&#243;n de la PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE versus <span class="elsevierStyleSup">11</span>C-colina en pacientes con c&#225;ncer de pr&#243;stata en reca&#237;da bioqu&#237;mica y evaluar in vivo la expresi&#243;n de receptores de la somatostatina con el fin de planificar terapias dirigidas &#40;<span class="elsevierStyleSup">177</span>Lu-DOTATATE&#41;&#46;</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Material y m&#233;todos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Analizamos prospectivamente 64 pacientes con reca&#237;da bioqu&#237;mica &#40;mediana PSA&#58; 4&#44;25 ng&#47;mL&#41;&#46; Se realiz&#243; una PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina y otra con <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46; Se midi&#243; el SUVm&#225;x en todas las lesiones&#46; Se consideraron como patr&#243;n de referencia las im&#225;genes correlativas&#44; histopatolog&#237;a y&#47;o seguimiento cl&#237;nico y bioqu&#237;mico&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La tasa de detecci&#243;n global por paciente fue del 48&#44;43&#37; para <span class="elsevierStyleSup">68</span>Ga-DOTATATE y de 46&#44;87&#37; para <span class="elsevierStyleSup">11</span>C-colina&#46; Los resultados fueron concordantes en 53 casos &#40;82&#44;81&#37;&#41;&#46; El SUV m&#225;ximo de la <span class="elsevierStyleSup">11</span>C-colina fue significativamente mayor que el correspondiente al <span class="elsevierStyleSup">68</span>Ga-DOTATATE para todas las lesiones concordantes &#40;n &#61; 130&#41;&#58; 6&#44;17 &#40;1&#44;7-15&#44;5&#41; versus 4&#44;38 &#40;1&#44;37-26&#44;7&#41;&#44; mediana &#40;rango&#41;&#44; para cada radiotrazador&#44; respectivamente &#40;P &#60; 0&#44;0001&#41;&#46; Los valores por paciente de sensibilidad y especificidad fueron los mismos para ambas t&#233;cnicas&#58; 0&#44;82 &#40;0&#44;65-0&#44;93&#41; y 0&#44;9 &#40;0&#44;73-0&#44;98&#41;&#44; respectivamente&#46; Aunque la diferencia no fue estad&#237;sticamente significativa&#44; la sensibilidad fue menor para pacientes con niveles de PSA inferiores&#58; 0&#44;63 vs&#46; 0&#44;89&#59; p &#61; 0&#44;13&#46; Se encontr&#243; una correlaci&#243;n significativa entre el SUVm&#225;x de ambos trazadores &#40;r &#61; 0&#44;41&#44; n &#61; 130&#44; p &#60; 0&#44;0001&#41;&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Conclusiones</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La PET&#47;TC con <span class="elsevierStyleSup">68</span>Ga-DOTATATE y la PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina parecen poseer alta capacidad de detecci&#243;n de lesiones patol&#243;gicas en la evaluaci&#243;n de los pacientes con c&#225;ncer de pr&#243;stata en reca&#237;da bioqu&#237;mica&#46; Se necesitan m&#225;s estudios con el fin de probar el posible valor cl&#237;nico complementario de estas t&#233;cnicas PET&#47;TC&#44; y para el <span class="elsevierStyleSup">68</span>Ga-DOTATATE para la potencial planificaci&#243;n de terapias mediadas por los receptores de somatostatina &#40;<span class="elsevierStyleSup">177</span>Lu-DOTATATE&#41;&#46;</p></span>"
        "secciones" => array:4 [
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          1 => array:2 [
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            "titulo" => "Material y m&#233;todos"
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        "titulo" => "Abstract"
        "resumen" => "<span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Background and objectives</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To prospectively compare the detection rate of <span class="elsevierStyleSup">68</span>Ga-DOTATATE versus <span class="elsevierStyleSup">11</span>C-choline PET&#47;CT in patients with prostate cancer in biochemical relapse&#44; and to evaluate somatostatin receptor expression in vivo to plan targeted therapies &#40;<span class="elsevierStyleSup">177</span>Lu-DOTATATE&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Material and methods</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">We prospectively analysed 64 patients with biochemical relapse &#40;median PSA&#58; 4&#46;25 ng&#47;mL&#41;&#46; A PET&#47;CT was performed with <span class="elsevierStyleSup">11</span>C-choline&#44; and another with <span class="elsevierStyleSup">68</span>Ga-DOTATATE&#46; The SUVmax was measured in all lesions&#46; The correlative images&#44; histopathology and&#47;or clinical and biochemical follow-up were taken as the reference standard&#46;</p></span> <span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Results</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The overall detection rate per patient was 48&#46;43&#37; for <span class="elsevierStyleSup">68</span>Ga-DOTATATE and 46&#46;87&#37; for <span class="elsevierStyleSup">11</span>C-choline&#46; The results were concordant in 53 cases &#40;82&#46;81&#37;&#41;&#46; The maximum SUV of <span class="elsevierStyleSup">11</span>C-choline was significantly higher than that of <span class="elsevierStyleSup">68</span>Ga-DOTATATE for all the concordant lesions &#40;n&#61;130&#41;&#58; 6&#46;17 &#40;1&#46;7-15&#46;5&#41; versus 4&#46;38 &#40;1&#46;37-26&#46;7&#41;&#44; median &#40;range&#41; for each radiotracer&#44; respectively &#40;<span class="elsevierStyleItalic">p</span> &#60; &#46;0001&#41;&#46; The sensitivity and specificity values per patient were the same for both techniques&#58; 0&#46;82 &#40;0&#46;65-0&#46;93&#41; and 0&#46;9 &#40;0&#46;73-0&#46;98&#41;&#44; respectively&#46; Although the difference was not significant&#44; the sensitivity was lower in patients with lower PSA levels&#58; 0&#46;63 vs&#46; 0&#46;89&#59; <span class="elsevierStyleItalic">p</span>&#61;&#46;13&#46; A significant correlation was found between the SUVmax of both tracers &#40;r &#61; 0&#46;41&#44; n &#61; 130&#44; <span class="elsevierStyleItalic">p</span> &#60;&#46;0001&#41;&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Conclusions</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleSup">68</span>Ga-DOTATATE PET&#47;CT and <span class="elsevierStyleSup">11</span>C-choline PET&#47;CT seem to have a high capacity to detect pathological lesions in the assessment of patients with prostate cancer with biochemical relapse&#46; Further studies are required to test the potential complementary value of these PET&#47;CT techniques&#44; and to evaluate the potential role of <span class="elsevierStyleSup">8</span>Ga-DOTATATE for planning somostatin receptor-mediated therapies &#40;<span class="elsevierStyleSup">177</span>Lu-DOTATATE&#41;&#46;</p></span>"
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          "es" => "<p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">Paciente n&#250;mero 28&#46; Paciente de 57 a&#241;os tratado con prostatectom&#237;a radical&#44; radioterapia y hormonoterapia con elementos de reca&#237;da bioqu&#237;mica &#40;PSA 4&#44;00 ng&#47;mL&#41;&#46; PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina a&#41; y <span class="elsevierStyleSup">68</span>Ga-DOTATATE b&#41; que muestran un resultado concordante positivo en una lesi&#243;n &#243;sea en el il&#237;aco izquierdo &#40;flechas&#41;&#46;</p>"
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          "es" => "<p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">Paciente n&#250;mero 62&#46; Paciente de 70 a&#241;os tratado con cirug&#237;a&#44; hormonoterapia&#44; radioterapia y poliquimioterapia&#46; Reca&#237;da bioqu&#237;mica con valor de PSA de 5&#44;26 ng&#47;mL&#46; Im&#225;genes de m&#225;xima ponderaci&#243;n &#40;MIP&#41; con <span class="elsevierStyleSup">11</span>C-colina a&#41; y <span class="elsevierStyleSup">68</span>Ga-DOTATATE b&#41;&#46; Adenopat&#237;a metast&#225;sica il&#237;aca interna izquierda demostrada con ambos radiotrazadores c&#41;&#46; Adenopat&#237;a il&#237;aca primitiva izquierda secundaria demostrada &#250;nicamente con el 11C-colina d&#41; y lesi&#243;n &#243;sea en hemicuerpo vertebral derecho de L2 demostrado &#250;nicamente con el <span class="elsevierStyleSup">68</span>Ga-DOTATATE e&#41; &#40;flechas amarillas&#41;&#46;</p>"
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          "es" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">Paciente n&#250;mero 32&#46; Paciente tratado con prostatectom&#237;a radical sin tratamiento adyuvante y reca&#237;da bioqu&#237;mica con PSA de 4&#44;59 ng&#47;mL&#46; Las im&#225;genes PET&#47;TC con <span class="elsevierStyleSup">11</span>C-colina a&#41; no muestran &#225;reas focales de hipercaptaci&#243;n anormal del radiotrazador sugestivas de actividad tumoral&#46; En b&#41; se muestra hipercaptaci&#243;n de <span class="elsevierStyleSup">68</span>Ga-DOTATATE en un ganglio linf&#225;tico perirrectal derecho y en una adenopat&#237;a presacra &#40;flechas rojas&#41; que fueron histol&#243;gicamente confirmados como un resultado falso positivo para met&#225;stasis &#40;inflamaci&#243;n&#41;&#46;</p>"
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          "es" => "<p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">Paciente n&#250;mero 19&#46; Hombre de 60 a&#241;os con c&#225;ncer de pr&#243;stata irradiado en 2014 y tratado posteriormente con hormonoterapia&#46; Actualmente reca&#237;da bioqu&#237;mica&#46; PSA en ascenso con valores de 1&#44;38 ng&#47;mL&#46; Hipercaptaci&#243;n asim&#233;trica de ambos radiof&#225;rmacos&#44; <span class="elsevierStyleSup">11</span>C-Colina &#40;a-c&#41; y <span class="elsevierStyleSup">68</span>Ga-DOTATATE &#40;d-f&#41;&#44; en la gl&#225;ndula prost&#225;tica cuya biopsia posterior revela tejido inflamatorio &#40;falso positivo&#41;&#46;</p>"
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        "etiqueta" => "Tabla 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "detalles" => array:1 [
          0 => array:3 [
            "identificador" => "at1"
            "detalle" => "Tabla "
            "rol" => "short"
          ]
        ]
        "tabla" => array:2 [
          "leyenda" => "<p id="spar0070" class="elsevierStyleSimplePara elsevierViewall">Cx&#58; cirug&#237;a&#59; HT&#58; hormonoterapia&#59; PQT&#58; poliquimioterapia&#59; PTE&#58; paciente&#59; RT&#58; radioterapia&#59; TTO&#58; tratamiento&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:2 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col"><span class="elsevierStyleSup">11</span>C-Colina&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col"><span class="elsevierStyleSup">68</span>Ga-DOTATATE&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr><tr title="table-row"><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Pte&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Edad&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Tto&#46;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">PSA&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Pr&#243;stata&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ganglios linf&#225;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#211;seo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Pr&#243;stata&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Ganglios linf&#225;ticos&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th><th class="td" title="table-head  " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">&#211;seo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">2&#44;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;PQT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">97&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 10&#47;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 14&#47;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 10&#47;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 14&#47;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#44;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 17&#47;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 14&#47;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 11&#47;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 13&#47;14&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 3&#47;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 4&#47;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&#47;PQT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">291&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 53&#47;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 11&#47;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;80&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">22&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">1&#44;69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">61&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">26&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">27&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">85&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">13&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">30&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">15&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">34&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#44;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">35&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">36&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">62&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">8&#44;82&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">17&#44;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">38&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;64&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">39&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">29&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">18&#44;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 3&#47;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 3&#47;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 3&#47;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">41&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 5&#47;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 5&#47;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">42&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">6&#44;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 17&#47;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 10&#47;17&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">43&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">63&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">5&#44;00&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&#47;PQT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">77&#44;24&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">45&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;40&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">47&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">10&#44;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 0&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 1&#47;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">72&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">3&#44;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">69&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">4&#44;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 2&#47;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">52&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">0&#44;32&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">59&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&#47;RT&#47;HT&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;90&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 4&#47;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">&#43; &#40;n &#61; 4&#47;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="table-entry ; entry_with_role_rowhead " align="left" valign="top">54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">65&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Cx&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">12&#44;51&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="table-entry  " align="left" valign="top">Negativo&nbsp;\t\t\t\t\t\t\n
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                        "volumen" => "2012"
                        "paginaInicial" => "921674"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22693495"
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