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All rights reserved" "documento" => "article" "crossmark" => 0 "subdocumento" => "fla" "cita" => "Rev Esp Patol. 2007;40:225-31" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 1642 "formatos" => array:3 [ "EPUB" => 9 "HTML" => 811 "PDF" => 822 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Adenoma hipofisario: estudio de la actividad proliferativa con Ki-67" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "225" "paginaFinal" => "231" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pituitary adenoma: study of proliferative activity with Ki-67" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "F. Ignacio Aranda López, María Niveiro de Jaime, Gloria Peiró Cabrera, Cristina Alenda González, Antonio Picó Alfonso" "autores" => array:5 [ 0 => array:2 [ "nombre" => "F. Ignacio" "apellidos" => "Aranda López" ] 1 => array:2 [ "nombre" => "María" "apellidos" => "Niveiro de Jaime" ] 2 => array:2 [ "nombre" => "Gloria" "apellidos" => "Peiró Cabrera" ] 3 => array:2 [ "nombre" => "Cristina" "apellidos" => "Alenda González" ] 4 => array:2 [ "nombre" => "Antonio" "apellidos" => "Picó Alfonso" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S169988550770082X?idApp=UINPBA00004N" "url" => "/16998855/0000004000000004/v1_201305061251/S169988550770082X/v1_201305061251/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1699885507700806" "issn" => "16998855" "doi" => "10.1016/S1699-8855(07)70080-6" "estado" => "S300" "fechaPublicacion" => "2007-10-01" "aid" => "70080" "copyright" => "Sociedad Española de Anatomía Patológica y Sociedad Española de Citología. All rights reserved" "documento" => "article" "crossmark" => 0 "subdocumento" => "rev" "cita" => "Rev Esp Patol. 2007;40:201-16" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6156 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 949 "PDF" => 5200 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Revisiones</span>" "titulo" => "Tumores Ováricos Borderline (de Bajo Potencial de Malignidad)" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "201" "paginaFinal" => "216" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Borderline Tumors of the Ovary (of Low Malignant Potential)" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Jaime Prat Díaz de Losada" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Jaime" "apellidos" => "Prat Díaz de Losada" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699885507700806?idApp=UINPBA00004N" "url" => "/16998855/0000004000000004/v1_201305061251/S1699885507700806/v1_201305061251/es/main.assets" ] "es" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Originales</span>" "titulo" => "Correlación entre parámetros morfológicos y expresión inmunohistoquímica de factores pronósticos en el carcinoma ductal infiltrante de mama" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "217" "paginaFinal" => "223" ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francisco Javier Torres Gómez, Francisco Javier Torres Olivera" "autores" => array:2 [ 0 => array:3 [ "nombre" => "Francisco Javier" "apellidos" => "Torres Gómez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "fn1" ] ] ] 1 => array:4 [ "nombre" => "Francisco Javier" "apellidos" => "Torres Olivera" "email" => array:1 [ 0 => "javiertorresgomez@yahoo.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "fn2" ] ] ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Correlation between morfological parameters and immunochemical expression of prognostic factors in the invasive ductal carcinoma of the breast" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2006-07-28" "fechaAceptado" => "2007-02-16" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec107159" "palabras" => array:7 [ 0 => "Carcinoma ductal infiltrante" 1 => "receptores estrogénicos" 2 => "p53" 3 => "c-erbB2" 4 => "grado histológico" 5 => "tamaño tumoral" 6 => "estatus ganglionar" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec107160" "palabras" => array:7 [ 0 => "invasive ductal carcinoma" 1 => "oestrogen receptors" 2 => "p53" 3 => "c-erbB2" 4 => "histologic grade" 5 => "tumoral size" 6 => "gangionar status" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span class="elsevierStyleSectionTitle">Introducción</span><p class="elsevierStyleSimplePara elsevierViewall">El carcinoma ductal infiltrante representa el tipo histológico más frecuente de los tumores malignos mamarios y muestra un comportamiento biológico bastante heterogéneo. La variable evolución de la enfermedad ha estimulado a los investigadores a definir los parámetros que permitan delimitar subgrupos de pacientes con el objetivo de optimizar la terapéutica. Los parámetros morfológicos han logrado este objetivo con resultados más o menos satisfactorios. Las técnicas inmunohistoquímicas han permitido señalizar nuevas rutas terapéuticas con resultados poco contrastados. La valoración comparativa de ambos parámetros está escasamente reflejada en la literatura.</p> <span class="elsevierStyleSectionTitle">Material y métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Se han determinado en 165 pacientes con carcinoma ductal infiltrante (NOS) el tamaño tumoral, grado histológico combinado, estatus ganglionar axilar y la expresión de receptores estrogénicos, p53 y c-erbB2, correlacionándose entre sí los parámetros morfológicos e inmunohistoquímicos.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Hemos obtenido correlación estadísticamente significativa entre la expresión positiva de receptores estrogénicos con el grado nuclear, índice mitósico, grado histológico, estatus ganglionar axilar y número de ganglios afectados cuando es superior a 4, pero no con la formación tubular ni con el tamaño tumoral. La diferente expresión de p53 no muestra variaciones significativas cuando se relaciona con los diferentes parámetros morfológicos. La expresión de cerbB2 se correlaciona con la formación tubular y el grado histológico pero no con el resto de los parámetros referidos.</p>" ] "en" => array:2 [ "titulo" => "Summary" "resumen" => "<span class="elsevierStyleSectionTitle">Introduction</span><p class="elsevierStyleSimplePara elsevierViewall">Invasive ductal carcinoma is the commonest malignant tumour of the breast and its behaviour is heterogeneous. Different therapeutic groups have been established depending on the morphologic features. Immunohistochemistry has opened new therapeutic options but the results are not contrasted enough.</p> <span class="elsevierStyleSectionTitle">Material and methods</span><p class="elsevierStyleSimplePara elsevierViewall">We have correlated tumoral size, combined histologic grade, axilar ganglionar status and p53, c-erbB2 and expression of estrogens receptors in 165 patients with invasive ductal carcinoma of the breast.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">There is statistic correlation between expression of estrogens receptors and nuclear grade, mitotic index, histologic grade, axilar ganglionar status and number of positive nodes. There is not correlation with the tumoral size and tubular differentiation. There are not significant alterations in p53 expression when it is correlated with the different morphologic parameters. CerbB2 expression correlates only with tubular differentiation and histologic grade.</p>" ] ] "NotaPie" => array:2 [ 0 => array:3 [ "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara">Unidad de Anatomía Patológica. Hospital de Alta Resolución de Utrera. Avda. Brigadas Internacionales, s/n. 41710 Utrera (Sevilla).</p>" "identificador" => "fn1" ] 1 => array:3 [ "etiqueta" => "2" "nota" => "<p class="elsevierStyleNotepara">Departamento de Anatomía Patológica. Hospital Universitario Virgen Macarena. Sevilla.</p>" "identificador" => "fn2" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:49 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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Correlación entre parámetros morfológicos y expresión inmunohistoquímica de factores pronósticos en el carcinoma ductal infiltrante de mama
Correlation between morfological parameters and immunochemical expression of prognostic factors in the invasive ductal carcinoma of the breast