array:23 [ "pii" => "S1699885517300065" "issn" => "16998855" "doi" => "10.1016/j.patol.2017.01.001" "estado" => "S300" "fechaPublicacion" => "2018-01-01" "aid" => "442" "copyright" => "Sociedad Española de Anatomía Patológica" "copyrightAnyo" => "2017" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Patol. 2018;51:23-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 287 "formatos" => array:3 [ "EPUB" => 13 "HTML" => 197 "PDF" => 77 ] ] "itemSiguiente" => array:18 [ "pii" => "S1699885516300800" "issn" => "16998855" "doi" => "10.1016/j.patol.2016.10.003" "estado" => "S300" "fechaPublicacion" => "2018-01-01" "aid" => "433" "copyright" => "Sociedad Española de Anatomía Patológica" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Patol. 2018;51:27-9" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 322 "formatos" => array:3 [ "EPUB" => 12 "HTML" => 157 "PDF" => 153 ] ] "es" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Artículo breve</span>" "titulo" => "Leiomioma de la uretra, localización inusual del tumor pélvico femenino más frecuente" "tienePdf" => "es" "tieneTextoCompleto" => "es" "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "27" "paginaFinal" => "29" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "An unusual location of urethral leiomyoma, the most common pelvic tumour in the female" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 2348 "Ancho" => 2667 "Tamanyo" => 2119503 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Tumor de bordes definidos y no invasivo (A: H&E ×10), con predominio de células fusiformes agrupadas en haces (B: H&E ×100), bien diferenciadas, con citoplasma eosinófilo y ausencia de mitosis y atipia (C: H&E ×200).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rubén Martínez-Castillo, Lucía Molina-Jiménez, María Jesús Pareja-Megía, Antonio Félix Conde-Martín, Antonio Robles-Frías" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Rubén" "apellidos" => "Martínez-Castillo" ] 1 => array:2 [ "nombre" => "Lucía" "apellidos" => "Molina-Jiménez" ] 2 => array:2 [ "nombre" => "María Jesús" "apellidos" => "Pareja-Megía" ] 3 => array:2 [ "nombre" => "Antonio Félix" "apellidos" => "Conde-Martín" ] 4 => array:2 [ "nombre" => "Antonio" "apellidos" => "Robles-Frías" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699885516300800?idApp=UINPBA00004N" "url" => "/16998855/0000005100000001/v1_201712290518/S1699885516300800/v1_201712290518/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1699885517300673" "issn" => "16998855" "doi" => "10.1016/j.patol.2017.08.002" "estado" => "S300" "fechaPublicacion" => "2018-01-01" "aid" => "463" "copyright" => "Sociedad Española de Anatomía Patológica" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Rev Esp Patol. 2018;51:18-22" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 336 "formatos" => array:3 [ "EPUB" => 3 "HTML" => 311 "PDF" => 22 ] ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief report</span>" "titulo" => "Lymphoepithelioma-like carcinoma of the large intestine: A case report and literature review" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:2 [ 0 => "en" 1 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "18" "paginaFinal" => "22" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Carcinoma tipo linfoepitelioma de intestino grueso: descripción de un caso y revisión de la literatura" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1125 "Ancho" => 1500 "Tamanyo" => 1017158 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">(A) Colorectal lymphoepithelioma-like carcinoma. Nests of malignant epithelial cells with peri and intratumoral lymphocytes (H-E, 100×). (B) Colorectal lymphoepithelioma-like carcinoma. Aggregates of polygonal epithelial cells with enlarged nuclei and eosinophilic nucleoli, broken by the presence of lymphocytes (H-E, 200×). (C) Colorectal medullary carcinoma. Sheets of poorly differentiated carcinoma with intratumoral lymphocytes. Inflammation is mainly peritumoral (H-E, 100×). (D) Colorectal medullary carcinoma. Continuous sheets of malignant epithelial cells, which predominate over lymphocytes (H-E, 200×).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Cristina Díaz del Arco, Fernando Esteban Collazo, Mª Jesús Fernández Aceñero" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Cristina" "apellidos" => "Díaz del Arco" ] 1 => array:2 [ "nombre" => "Fernando" "apellidos" => "Esteban Collazo" ] 2 => array:2 [ "nombre" => "Mª Jesús" "apellidos" => "Fernández Aceñero" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1699885517300673?idApp=UINPBA00004N" "url" => "/16998855/0000005100000001/v1_201712290518/S1699885517300673/v1_201712290518/en/main.assets" ] "en" => array:19 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Brief report</span>" "titulo" => "Histiocytic sarcoma with bladder involvement: Case report and literature review" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "23" "paginaFinal" => "26" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Mª Jesús Fernández-Aceñero, Pablo Pérez Alonso, Cristina Díaz del Arco" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Mª Jesús" "apellidos" => "Fernández-Aceñero" "email" => array:1 [ 0 => "mgg10167@gmail.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "Pablo" "apellidos" => "Pérez Alonso" ] 2 => array:2 [ "nombre" => "Cristina" "apellidos" => "Díaz del Arco" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Department of Surgical Pathology, Hospital Clínico Universitario San Carlos, Madrid, Spain" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Sarcoma histiocítico con afectación vesical: notificación de un caso y revisión de la bibliografía" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1243 "Ancho" => 1650 "Tamanyo" => 415194 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Indentation of the tumor cells nuclei, suggesting histiocytic origin (H-E, 400×).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Neoplasms originating from histiocytic and dendritic cells are very uncommon, representing less than 1% of all hematolymphoid neoplasms.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">1</span></a> The most recent 2008 classification of hematolymphoid tumors has established clear-cut criteria for the diagnosis of these neoplasms.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">2</span></a> Within this category we find Langerhans cell histiocytosis (LCH), histiocytic sarcoma (HC), follicular dendritic cell sarcoma (FDCS), interdigitating cell sarcoma (ICS), indeterminate dendritic cell sarcoma (IDCS) and fibroblastic reticular cell tumor (FRCT), with presumed different embryological origins. Although the old term histiocytic tumors persists, in fact most of them are not truly macrophagic, but originate rather from stem cell CD34+ precursors. Diagnosis of these tumors relies on immunohistochemistry (IHC), for they share morphological features with many other malignant tumors. Due to their infrequency, therapeutical experience is limited; in the literature there are isolated case reports or short case series. Interestingly, our literature review revealed many veterinary cases; this kind of tumor would appear to be much more frequent in animals, especially in dogs and cats.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">3,4</span></a> We report a case of histiocytic sarcoma that presented with urinary symptoms and discuss the differential diagnoses and possible associations.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Case report</span><p id="par0010" class="elsevierStylePara elsevierViewall">An 80-year-old Caucasian man presented with hematuria and back pain. He had a past history of diffuse large B cell lymphoma in 2006 with node and spleen involvement, for which he had been splenectomized and treated with cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) and rituximab with a favorable response. Follow-ups at the Hematology Unit of Hospital Clínico San Carlos showed no recurrences. In February 2016 he presented with acute hematuria and back pain. Serial urine cytological samples showed no malignant urothelial cells and no further action was taken. Eight months later during a routine follow-up consultation he complained of weight loss and malaise. Computed tomography (CT) showed enlarged retroperitoneal lymph nodes. Positron emission tomography–computed tomography (PET-TC) did not show any increased glucose uptake in nodes, but revealed a suspicious lesion in the bladder. Cystoscopy revealed a large infiltrating ulcerative mass involving the bladder wall. Transurethral resection (TUR) of the mass obtained a fairly large amount of tumor tissue.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Histopathology showed a diffuse neoplasm, composed of medium sized cells with abundant clear cytoplasm and irregular and slightly pleomorphic nuclei (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Most cells had prominent nucleoli, but no melanin pigment was found. The overall picture was concordant with a clear cell carcinoma. The tumor cells widely infiltrated the muscular layer with vascular invasion. Immunohistochemistry for cytokeratin (wide spectrum AE1-AE3) was negative, as it was for GATA3 and epithelial membrane antigen (EMA). P63 was positive in 30% of the tumor cells. Subsequently we performed a much wider immunohistochemical panel, including melanocytic, lymphoid and muscular specific markers (namely, HMB45, Melan A, S100 protein, CD20, CD79a, BCL2, BCL6, CD10, CD3, desmin and actin) with negative results. The lack of specific IHC staining led us to review the H&E stained slides and we noted that some tumor cell nuclei showed a clear indentation (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>). For this reason we added immunohistochemical markers of hystiocytic differentiation, namely CD68 (EBM clone 11, Dako Denmark), which was intensely positive (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>). We then performed CD45, fascin, CD23, CD21, CD1a and lysozime to discard dendritic follicular cells or Langerhans cells origin. Only lysozime and fascin were positive and we could establish a definite diagnosis of histiocytic sarcoma. PCR was performed and confirmed rearrangement of IgH in the tumor.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia><elsevierMultimedia ident="fig0015"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Due to the advanced age of the patient and the clear and fast decline in his overall condition, no adjuvant therapy was given; he received palliative care only. He died one month after diagnosis.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Discussion</span><p id="par0025" class="elsevierStylePara elsevierViewall">Histiocytic tumors are very rare neoplasms, comprising less than 1% of all hematological malignancies.<a class="elsevierStyleCrossRefs" href="#bib0115"><span class="elsevierStyleSup">1,2</span></a> Histologically, these lesions are hard to diagnose, for they share morphological similarities with many other malignant neoplasms, including carcinoma, epitheloid sarcomas and melanomas. The advent of IHC staining has made diagnosis easier, for these lesions are shown to express common markers of histiocytic lineage, such as CD68 or lysozime. The 2008 WHO classification of lymphoid neoplasms recognizes six different entities within the histiocytic malignant tumors, which can reliably be distinguished with IHC markers.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">2</span></a> Emile et al. proposed a new classification of histiocytic tumors into 4 groups: Langerhans group, malignant histiocytosis group, R group (Rosai-Dorfman disease and non-cutaneous non-Langerhans cell histiocytosis) and H group (hemophagocytic lymphohistiocytosis and macrophage activation syndrome).<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">5</span></a> In the most recent WHO classification and for the first time, the presence of B and/or T cell rearrangement does not preclude diagnosis of histiocytic lineage, for it has been clearly shown that some bona-fide histiocytic tumors have this kind of molecular abnormality, common to other lymphoid malignant neoplasms.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">6</span></a> The new WHO classification is very similar to the previous one, except for the order of the entities and the addition of Erdheim-Chester disease. Moreover, BRAFV600E mutation has been observed in Langerhans cell histiocytosis, histiocytic sarcoma, follicular dendritic cell sarcoma, disseminated juvenile xanthogranuloma and Erdheim-Chester disease.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The most frequent histiocytic neoplasm is Lagerhans cell histiocytosis (LCH) and all the other entities seem to be rather infrequent. A recent retrospective 25 year-review from a single center found 32 cases of histiocytic malignant tumors, 62% of which were LCH.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">8</span></a> Histiocytic sarcoma was second in frequency with 6 cases in the series.</p><p id="par0035" class="elsevierStylePara elsevierViewall">HS usually affects middle-aged adults (median age 46–55 years), although there have been some reports in children<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">9</span></a> or adolescents.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">10</span></a> Both sexes are equally affected, although some reports suggest a slight male preponderance. Prognosis is intermediate with a median survival of 52 months, with a wide variation according to stage and location.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">8</span></a> Disease is usually localized at the time of diagnosis, but it can also present with widespread disease. It most frequently involves nodes, bone marrow, intestine, brain and skin.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">11</span></a> However, there are exceptional reports of cases involving the uterine cervix,<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">12</span></a> the choroid<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">13</span></a> or the liver.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">14</span></a> To the best of our knowledge there are no previous reports of bladder involvement by HS.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Most patients have no previous history of disease (so-called primary HS), although some HS have affected people with kidney transplantation.<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">15</span></a> A rather common association of these lesions is with lymphoid neoplasms, that can arise both prior or subsequent to diagnosis of HS. Old classifications discarded HS diagnosis when B and/or T cell rearrangements were found and considered these cases as dedifferentiation of a previous lymphoma, but the 2008 WHO classification allows diagnosis of HS even in the presence of these rearrangements for HS is considered a transdifferentiation or a dual differentiation within lymphoid neoplasms. Malignant lymphoma can precede HS, even for decades,<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">16–18</span></a> but it can also be synchronous with or even present after HS diagnosis.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">19</span></a> In our patient diffuse large B cell lymphoma had been diagnosed and treated 10 years before with good results. The present neoplasm did not show any marker of lymphoid lineage (it was negative for CD20, CD79a, CD10, MUM1, BCL2 and BCL6), although it preserved the clonal rearrangement of IgH, as already described in the literature. This fact has been interpreted either as transdifferentiation or divergent differentiation from a similar stem cell.</p><p id="par0045" class="elsevierStylePara elsevierViewall">Diagnosis is based on histopathological features and IHC studies. These neoplasms do not show any specific growth pattern and are usually diffuse proliferations of medium to large cells with clear and even xanthomized cytoplasm. Differential diagnosis of these tumors is extensive and includes neoplasms of almost any lineage. However, careful inspection usually reveals histopathological features of histiocytic differentiation, such as nuclear indentation or small multiple nucleoli. Keratins, melanocytic markers and lymphoid markers should, by definition, be negative in HS, as should muscle cell and neural ones. Definitive diagnosis relies on the expression of histiocytic markers, like CD68, lysozime or fascin, coupled with the lack of expression of markers of specific lineage, like CD1a and langerin (LCH) or CD23 and CD21 (FDCS).<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">8</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">Therapy is not well standardized, for most cases are sporadic and series are rather short. However, there seems to be agreement that surgical resection is the mainstay of therapy, followed in disseminated cases by chemotherapy and/or radiation therapy to control local recurrence after surgery. Recent studies have analyzed the molecular abnormalities in HS by next generation sequencing, to find that most HS carry somatic mutations in BRAF, mainly G464V and N581S.<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">20</span></a> In the evolving era of personalized medicine and targeted therapy these new insights into the molecular features of tumors could lead to the development of targeted strategies of therapy that could improve prognosis.<a class="elsevierStyleCrossRef" href="#bib0215"><span class="elsevierStyleSup">21</span></a> In this respect a recent report by Coutermarsh-Ott et al.<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">22</span></a> has proposed NF-kB signaling inhibition as a means to control disease.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Ethical disclosures</span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Protection of human and animal subjects</span><p id="par0055" class="elsevierStylePara elsevierViewall">The authors declare that no experiments were performed on humans or animals for this study.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Confidentiality of data</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors declare that they have followed the protocols of their work center on the publication of patient data.</p></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Right to privacy and informed consent</span><p id="par0065" class="elsevierStylePara elsevierViewall">The authors declare that no patient data appear in this article.</p></span></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Funding</span><p id="par0070" class="elsevierStylePara elsevierViewall">The authors acknowledge no funding for the elaboration of the present study.</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conflicts of interest</span><p id="par0075" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres962272" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec932649" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres962271" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec932650" "titulo" => "Palabras clave" ] 4 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 5 => array:2 [ "identificador" => "sec0010" "titulo" => "Case report" ] 6 => array:2 [ "identificador" => "sec0015" "titulo" => "Discussion" ] 7 => array:3 [ "identificador" => "sec0020" "titulo" => "Ethical disclosures" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0025" "titulo" => "Protection of human and animal subjects" ] 1 => array:2 [ "identificador" => "sec0030" "titulo" => "Confidentiality of data" ] 2 => array:2 [ "identificador" => "sec0035" "titulo" => "Right to privacy and informed consent" ] ] ] 8 => array:2 [ "identificador" => "sec0040" "titulo" => "Funding" ] 9 => array:2 [ "identificador" => "sec0045" "titulo" => "Conflicts of interest" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-11-29" "fechaAceptado" => "2017-01-23" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec932649" "palabras" => array:4 [ 0 => "Malignant lymphoma" 1 => "Histiocytic neoplasms" 2 => "Sarcoma" 3 => "Bladder tumors" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec932650" "palabras" => array:4 [ 0 => "Linfoma maligno" 1 => "Neoplasia histiocítica" 2 => "Sarcoma" 3 => "Tumores vesicales" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">We report an unusual case of histiocytic sarcoma with bladder involvement. An 80 year-old man with a previous history of diffuse large B-cell malignant lymphoma presented with hematuria and back pain. Serial urine cytologies revealed no urothelial malignant cells, but cystoscopy showed a large intravesical mass. The patient underwent transurethral resection (TUR) of the tumor. The bladder TUR specimen showed a widely infiltrating epithelioid neoplasm, with intense immunohistochemical positivity for CD45 and histiocytic markers (CD68, lysozime and fascin). Histopathological diagnosis was histiocytic sarcoma. As the patient's condition was progressively deteriorating, only palliative care was indicated and he died one month after TUR. Although histiocytic sarcoma can often be widespread at the time of diagnosis, to our knowledge, this is the first report of a case presenting with urinary symptoms. Histiocytic sarcoma can mimic many other malignant lesions, and only immunohistochemistry can define the tumor cells, allowing correct therapy. We discuss the differential diagnosis and possible associations.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Presentamos un caso infrecuente de sarcoma histiocítico con afectación vesical. Varón de 80 años con historia previa de linfoma maligno difuso de células B grandes que presenta hematuria y dolor de espalda. Citologías seriadas de orina no mostraron células uroteliales malignas, pero una citoscopia reveló una gran masa intravesical. Se practicó una resección transuretral del tumor. La resección transuretral de la vejiga mostró una neoplasia tipo epitelioide con fuerte expresión de CD45 y de marcadores histiocíticos tales como CD68 lisozima y fascina con diagnóstico de sarcoma histiocítico. Tras el estudio, el paciente se deterioró progresivamente indicándose solo cuidados paliativos, con exitus al mes de la cirugía. Aunque el sarcoma histiocítico suele estar en estadio avanzado en el momento del diagnóstico, creemos que este caso es el primero en comenzar con síntomas urinarios. El sarcoma histiocítico puede simular diversas lesiones neoplásicas, siendo la inmunohistoquímica necesaria para un diagnóstico correcto. Discutimos diagnósticos diferenciales y posibles asociaciones.</p></span>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1243 "Ancho" => 1650 "Tamanyo" => 462035 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Low power view of the tumor cells showing clear cytoplasms and slightly pleomorphic nuclei (H-E 100×).</p>" ] ] 1 => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1243 "Ancho" => 1650 "Tamanyo" => 415194 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Indentation of the tumor cells nuclei, suggesting histiocytic origin (H-E, 400×).</p>" ] ] 2 => array:7 [ "identificador" => "fig0015" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 1243 "Ancho" => 1650 "Tamanyo" => 493890 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">CD68 intense expression in the tumor cells (IHC for CD68, 200×).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:22 [ 0 => array:3 [ "identificador" => "bib0115" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tumours of histiocytes and accessory dendritic cells: an immunohistochemical approach to classification from the international lymphoma study group based on 61 cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S.A. 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