metricas
covid
Buscar en
Revista de Psiquiatría y Salud Mental (English Edition)
Toda la web
Inicio Revista de Psiquiatría y Salud Mental (English Edition) Bipolar disorder: what effect does treatment adherence have on risk of suicidal ...
Información de la revista
Vol. 2. Núm. 1.
Páginas 42-48 (enero 2009)
Compartir
Compartir
Descargar PDF
Más opciones de artículo
Vol. 2. Núm. 1.
Páginas 42-48 (enero 2009)
Acceso a texto completo
Bipolar disorder: what effect does treatment adherence have on risk of suicidal behavior?
Trastorno bipolar: ¿qué efecto tiene el cumplimiento terapéutico en el riesgo de conductas suicidas?
Visitas
1347
Jorge López-Castromana,
Autor para correspondencia
jorgecastroman@gmail.com

Corresponding author.
, Enrique Baca-Garcíaa,b, María A. Oquendob
a Department of Psychiatry, Fundacion Jiménez Díaz Hospital, Autonoma University of Madrid, Madrid, Spain
b Department of Psychiatry, New York State Psychiatric Institute and Columbia University, New York, USA
Este artículo ha recibido
Información del artículo
Abstract

Bipolar disorder is associated with high risk for suicidal behavior. Lack of adherence to treatment is one factor that may be partly responsible for this common complication. We searched MEDLINE with the combination of the key words “compliance” or “adherence” with “suicide” and “bipolar”, limited to English language papers published between 1990 and July 2008.We evaluate the existent literature studying the influence of treatment adherence on suicidality among these patients. Our findings show a limited number of studies addressing this issue, mostly conducted with patients enrolled in lithium clinics. Results suggest an association between non-adherence and an increased risk of suicidal behavior among bipolar patients. Whether non-adherence leads to increase risk of suicidality due to specific properties of interventions such as lithium treatment or simply is secondary to mood stabilization is still an open question.

Keywords:
Suicide
Compliance
Comorbidity
Lithium
Resumen

El trastorno bipolar conlleva un riesgo elevado de conductas suicidas. La falta de cumplimiento terapéutico es uno de los factores que, en parte, puede ser la causa de esta complicación frecuente. Realizamos una búsqueda en MEDLINE con la combinación de las palabras clave “compliance” o “adherence” con “suicide” y “bipolar”, y limitada a los artículos publicados en inglés entre 1990 y julio de 2008. Hemos evaluado la literatura médica existente en la que se ha estudiado la influencia del cumplimiento terapéutico en las tendencias suicidas en estos pacientes. Nuestros resultados muestran un número limitado de estudios en los que se ha abordado esta cuestión, la mayoría de ellos llevados a cabo en pacientes registrados en clínicas en que se usa el litio. Los datos obtenidos indican una relación entre la falta de adherencia y el aumento de riesgo de conducta suicida en los pacientes bipolares. Continúa estando sin resolver la cuestión de si la falta de adherencia conduce a un aumento del riesgo de tendencias suicidas a causa de las propiedades específicas de intervenciones como el tratamiento con litio o ello es simplemente secundario a la estabilización del estado de ánimo.

Palabras clave:
Suicidio
Cumplimiento
Comorbilidad
Litio
El Texto completo está disponible en PDF
References
[1.]
G.S. Sachs.
Unmet clinical needs in bipolar disorder.
J Clin Psychopharmacol, 233 (2003), pp. S2-S8
[2.]
A. Brodersen, R.W. Licht, P. Vestergaard, A.V. Olesen, P.B. Mortensen.
Sixteen-year mortality in patients with affective disorder commenced on lithium.
Br J Psychiatry, 176 (2000), pp. 429-433
[3.]
R. Sharma, H.R. Markar.
Mortality in affective disorder.
J Affect Disord, 31 (1994), pp. 91-96
[4.]
M. Sajatovic.
Bipolar disorder: disease burden.
Am J Manag Care, 11 (2005), pp. 80-83
[5.]
M.M. Weissman, R.C. Bland, G.J. Canino, C. Faravelli, S. Greenwald, H.G. Hwu, et al.
Cross-national epidemiology of major depression and bipolar disorder.
JAMA, 276 (1996), pp. 293-299
[6.]
R.C. Kessler, W.T. Chiu, O. Demler, K.R. Merikangas, E.E. Walters.
Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication.
Arch Gen Psychiatry, 62 (2005), pp. 627
[7.]
J. Angst.
The emerging epidemiology of hypomania and bipolar II disorder.
J Affect Disord, 50 (1998), pp. 143-151
[8.]
M. Ten Have, W. Vollebergh, R. Bijl, W.A. Nolen.
Bipolar disorder in the general population in the Netherlands (prevalence, consequences and care utilisation): results from the Netherlands Mental Health Survey and Incidence Study (NEMESIS).
J Affect Disord, 68 (2002), pp. 203-213
[9.]
B.F. Grant, F.S. Stinson, D.S. Hasin, D.A. Dawson, S.P. Chou, W.J. Ruan, et al.
Prevalence, correlates, and comorbidity of bipolar I disorder and axis I and II disorders: results from the National Epidemiologic Survey on Alcohol and Related Conditions.
J Clin Psychiatry, 66 (2005), pp. 1205-1215
[10.]
R.V. Bijl, A. Ravelli, G. van Zessen.
Prevalence of psychiatric disorder in the general population: results of the Netherlands Mental Health Survey and Incidence Study (NEMESIS).
Soc Psychiatry Psychiatr Epidemiol, 33 (1998), pp. 581-586
[11.]
D.L. Dunner.
Clinical consequences of under-recognized bipolar spectrum disorder.
Bipolar Disorders, 5 (2003), pp. 456-463
[12.]
R.M. Hirschfeld.
Bipolar spectrum disorder: improving its recognition and diagnosis.
J Clin Psychiatry, 62 (2001), pp. 5-9
[13.]
M.G. Carta, J. Angst.
Epidemiological and clinical aspects of bipolar disorders: controversies or a common need to redefi ne the aims and methodological aspects of surveys.
Clin Pract Epidemol Ment Health, 1 (2007), pp. 1-4
[14.]
World Health Organization. The World Health Report 2001; Mental Health: New Understanding, New Hope. Geneva: World Health Organization; 2001.
[15.]
R.M. Hirschfeld, L.A. Vornik.
Bipolar disorder – costs and comorbidity.
Am J Manag Care, 11 (2005), pp. 85-90
[16.]
S. Pini, V. de Queiroz, D. Pagnin, L. Pezawas, J. Angst, G.B. Cassano, et al.
Prevalence and burden of bipolar disorders in European countries.
Eur Neuropsychopharmacol, 15 (2005), pp. 425-434
[17.]
D. Chisholm, M. van Ommeren, J.L. Ayuso-Mateos, S. Saxena.
Costeffectiveness of clinical interventions for reducing the global burden of bipolar disorder.
Br J Psychiatry, 187 (2005), pp. 559-567
[18.]
J. Angst, A. Gamma, R. Sellaro, P.W. Lavori, H. Zhang.
Recurrence of bipolar disorders and major depression. A life-long perspective.
Eur Arch Psychiatry Clin Neurosci, 253 (2003), pp. 236-240
[19.]
P. Courtet, F. Jollant, D. Castelnau, B. Astruc, C. Buresi, A. Malafosse.
Implication of genes of the serotonergic system on vulnerability to suicidal behavior.
J Psychiatry Neurosci, 29 (2004), pp. 10
[20.]
P. Qin, E. Agerbo, P.B. Mortensen.
Suicide risk in relation to socioeconomic, demographic, psychiatric, and familial factors: a national register-based study of all suicides in Denmark, 1981–1997.
Am J Psychiatry, 160 (2003), pp. 765-772
[21.]
L. Tondo, G. Isacsson, R. Baldessarini.
Suicidal behaviour in bipolar disorder: risk and prevention.
CNS Drugs, 17 (2003), pp. 491-511
[22.]
G. Emilien, L. Septien, C. Brisard, E. Corruble, M. Bourin.
Bipolar disorder: how far are we from a rigorous defi nition and effective management?.
Prog Neuropsychopharmacol Biol Psychiatry, 31 (2007), pp. 975-996
[23.]
Y.W. Chen, S.C. Dilsaver.
Lifetime rates of suicide attempts among subjects with bipolar and unipolar disorders relative to subjects with other Axis I disorders.
Biol Psychiatry, 39 (1996), pp. 896-899
[24.]
R.C. Kessler, D.R. Rubinow, C. Holmes, J.M. Abelson, S. Zhao.
The epidemiology of DSM-III-R bipolar I disorder in a general population survey.
Psychol Med, 27 (1997), pp. 1079-1089
[25.]
R.J. Baldessarini, M. Pompili, L. Tondo.
Suicide in bipolar disorder: Risks and management.
CNS Spectr, 11 (2006), pp. 465-471
[26.]
World Health Organization, Adherence to long-term therapies: evidence for action. Geneva: World Health Organization; 2003.
[27.]
L. Tondo, K.R. Jamison, R.J. Baldessarini.
Effect of lithium maintenance on suicidal behavior in major mood disorders.
Ann N Y Acad Sci, 836 (1997), pp. 339-351
[28.]
L.V. Kessing, L. Søndergård, K. Kvist, P.K. Andersen.
Suicide risk in patients treated with lithium.
Arch Gen Psychiatry, 62 (2005), pp. 860-866
[29.]
C. Schumann, G. Lenz, A. Berghöfer, B. Müller-Oerlinghausen.
Non-adherence with long-term prophylaxis: a 6-year naturalistic follow-up study of affectively ill patients.
Psychiatry Res, 89 (1999), pp. 247-257
[30.]
R. Guscott, L. Taylor.
Lithium prophylaxis in recurrent affective illness. Efficacy, effectiveness and effi ciency.
Br J Psychiatry, 164 (1994), pp. 741-746
[31.]
R. Lingam, J. Scott.
Treatment non-adherence in affective disorders.
Acta Psychiatr Scand., 105 (2002), pp. 164-172
[32.]
J. Scott, M. Pope.
Nonadherence with mood stabilizers: prevalence and predictors.
J Clin Psychiatry, 63 (2002), pp. 384-390
[33.]
F. Colom, E. Vieta, M.J. Tacchi, J. Sánchez-Moreno, J. Scott.
Identifying and improving non-adherence in bipolar disorders.
Bipolar Disord, 7 (2005), pp. 24-31
[34.]
M. Schou.
The combat of non-compliance during prophylactic lithium treatment.
Acta Psychiatr Scand, 95 (1997), pp. 361-363
[35.]
J.M. Bostwick, V.S. Pankratz.
Affective disorders and suicide risk: a reexamination.
Am J Psychiatry, 157 (2000), pp. 1925-1932
[36.]
A. Coppen, H. Standish-Barry, J. Bailey, G. Houston, P. Silcocks, C. Hermon.
Does lithium reduce the mortality of recurrent mood disorders?.
J Affect Disord, 23 (1991), pp. 1-7
[37.]
W. Greil, N. Kleindienst.
Concepts in the treatment of bipolar disorder.
Acta Psychiatr Scand Suppl, 418 (2003), pp. 41-46
[38.]
B. Muller-Oerlinghausen.
Arguments for the specifi city of the antisuicidal effect of lithium.
Eur Arch Psychiatry Clin Neurosci, 251 (2001), pp. II72-II75
[39.]
R.J. Baldessarini, L. Tondo, P. Davis, M. Pompili, F.K. Goodwin, J. Hennen.
Decreased risk of suicides and attempts during longterm lithium treatment: a meta-analytic review.
Bipolar Disorders, 8 (2006), pp. 625-639
[40.]
B. Muller-Oerlinghausen, B. Muser-Causemann, J. Volk.
Suicides and parasuicides in a high-risk patient group on and off lithium long-term medication.
J Affect Disord, 25 (1992), pp. 261-269
[41.]
N. Kleindienst, W. Greil.
Differential efficacy of lithium and carbamazepine in the prophylaxis of bipolar disorder: results of the MAP study.
Neuropsychobiology, 42 (2000), pp. 2-10
[42.]
B.I. Yerevanian, R.J. Koek, J. Mintz.
Bipolar pharmacotherapy and suicidal behavior. Part I: Lithium, divalproex and carbamazepine.
J Affect Disord, 103 (2007), pp. 5-11
[43.]
B.I. Yerevanian, R.J. Koek, J. Mintz, H.S. Akiskal.
Bipolar pharmacotherapy and suicidal behaviour Part 2. The impact of antidepressants.
J Affect Disord, 103 (2007), pp. 13-21
[44.]
B.I. Yerevanian, R.J. Koek, J. Mintz.
Bipolar pharmacotherapy and suicidal behavior Part 3: impact of antipsychotics.
J Affect Disord, 103 (2007), pp. 23-28
[45.]
R.J. Baldessarini, R. Perry, J. Pike.
Factors associated with treatment nonadherence among US bipolar disorder patients.
Hum Psychopharmacol, 23 (2008), pp. 95-105
[46.]
N. Kleindienst, W. Greil.
Are illness concepts a powerful predictor of adherence to prophylactic treatment in bipolar disorder?.
J Clin Psychiatry, 65 (2004), pp. 966-974
[47.]
E. Vieta, A.R. Rosa.
Evolving trends in the long-term treatment of bipolar disorder.
World J Biol Psychiatry, 8 (2007), pp. 4-11
[48.]
H.A. Swartz, E. Frank.
Psychotherapy for bipolar depression: a phase-specifi c treatment strategy?.
Bipolar Disord, 3 (2001), pp. 11-22
[49.]
D.J. Miklowitz.
Psychotherapy in combination with drug treatment for bipolar disorder.
J Clin Psychopharmacol, 162 (1996), pp. S56-S66
[50.]
D.J. Miklowitz, E.L. George, J.A. Richards, T.L. Simoneau, R.L. Suddath.
A randomized study of family-focused psychoeducation and pharmacotherapy in the outpatient management of bipolar disorder.
Arch Gen Psychiatry, 60 (2003), pp. 904-912
[51.]
F.R. Johnson, S. Ozdemir, R. Manjunath, A.B. Hauber, S.P. Burch, T.R. Thompson.
Factors that affect adherence to bipolar disorder treatments: a stated-preference approach.
Med Care, 45 (2007), pp. 545-552
[52.]
A. Nilsson, R. Axelsson.
Factors associated with discontinuation of long-term lithium treatment.
Acta Psychiatr Scand, 80 (1989), pp. 221-230
[53.]
A. Gonzalez-Pinto, F. Mosquera, M. Alonso, P. López, F. Ramírez, E. Vieta, R.J. Baldessarini.
Suicidal risk in bipolar I disorder patients and adherence to long-term lithium treatment.
Bipolar Disord, 8 (2006), pp. 618-624
[54.]
J.T. Cavanagh, M. Van Beck, W. Muir, D.H. Blackwood.
Case-control study of neurocognitive function in euthymic patients with bipolar disorder: an association with mania.
Br J Psychiatry, 180 (2002), pp. 320-326
[55.]
C.F. Yen, C.P. Cheng, C.H. Ko, J.Y. Yen, C.F. Huang, C.S. Chen.
Suicidality and its association with insight and neurocognition in Taiwanese patients with bipolar I disorder in remission.
J Nerv Ment Dis, 196 (2008), pp. 462-467
[56.]
X.F. Amador, J.H. Friedman, C. Kasapis, S.A. Yale, M. Flaum, J.M. Gorman.
Suicidal behavior in schizophrenia and its relationship to awareness of illness.
Am J Psychiatry, 153 (1996), pp. 1185-1188
[57.]
M. Mazza, L. Mandelli, M. Di Nicola, D. Harnic, V. Catalano, D. Tedeschi, et al.
Clinical features, response to treatment and functional outcome of bipolar disorder patients with and without cooccurring substance use disorder: 1-year follow-up.
J Affect Disord, (2008),
[58.]
E.J. Kilbane, N.S. Gokbayrak, I. Galynker, L. Cohen, S. Tross.
A review of panic and suicide in bipolar disorder: Does comorbidity increase risk?.
J Affect Disord, (2008),
[59.]
F. Colom, E. Vieta, A. Martinez-Aran.
Clinical factors associated with treatment noncompliance in euthymic bipolar patients.
J Clin Psychiatry, 61 (2000), pp. 549-555
[60.]
E. Vieta, F. Colom, B. Corbella, A. Martínez-Arán, M. Reinares, A. Benabarre, et al.
Clinical correlates of psychiatric comorbidity in bipolar I patients.
Bipolar Disorders, 3 (2001), pp. 253-258
[61.]
G.S. Leverich, L.L. Altshuler, M.A. Frye, T. Suppes, P.E. Keck Jr., S.L. McElroy, et al.
Factors associated with suicide attempts in 648 patients with bipolar disorder in the Stanley Foundation Bipolar Network.
J Clin Psychiatry, 64 (2003), pp. 506-515
[62.]
E. Isometsa.
Suicide in bipolar I disorder in Finland: psychological autopsy fi ndings from the National Suicide Prevention Project in Finland.
Arch Suicide Res, 9 (2005), pp. 251-260
[63.]
M. Sajatovic, K. Biswas, A.K. Kilbourne, H. Fenn, W. Williford, M.S. Bauer.
Factors associated with prospective longterm treatment adherence among individuals with bipolar disorder.
Psychiatr Serv, 59 (2008), pp. 753-759
Copyright © 2009. SEP y SEPB
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos