Raloxifeno

Pérez-Edo, Luis

doi:10.1016/S1577-3566(05)74492-4

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Resumen

Bibliografía

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Resumen

El raloxifeno es un modulador selectivo de los receptores estrogénicos (SERM) derivado del grupo químico del benzotiofeno. Su acción se centra en un efecto agonista estrogénico en el hueso y el sistema cardiovascular, y antagonista en el tejido mamario y endometrial.

Es el único SERM que ha demostrado un efecto positivo en la reducción de las fracturas vertebrales, y además en la reducción del cáncer de mama y la afección cardiovascular. Estas características le confieren una especial indicación en la prevención y el tratamiento de la osteoporosis, sin los efectos indeseables de los estrógenos en la mama y en el endometrio. A diferencia de los estrógenos, no resuelve la sintomatología climatérica, y además el riesgo de trombosis venosa profunda es semejante.

El raloxifeno es un fármaco con suficiente experiencia clínica en su manejo, y es de primera línea de elección en la osteoporosis, dentro del grupo de los antirresortivos.

Palabras clave:

Raloxifeno

Osteoporosis

Fracturas

Cáncer mama

Abstract

Raloxifene is a Selective Estrogen Receptor Modulator (SERM), derived from the Benzothiophene's chemical group. Its action focuses on an estrogenic agonist action to the bone and the cardiovascular system, and antagonist to the breast and endometrial tissue.

It is the only SERM that has proven a positive effect in diminishing vertebral fracture risk, and furthermore, reduction in breast cancer and cardiovascular pathologies. These characteristics bestow on raloxifene a special indication on osteoporosis treatment and prevention, without the undesirable effects related to the estrogen action on the breast and endometrium. The main difference to estrogens is that of it does not succeed in the climateric symptomathology and besides, yelds similar venous thrombosis risk.

Raloxifene is a pharmacy, within the antiresortive group, with enough clinical experience in its handling, such as to constitute yields as a front line pharmac on osteoporosis.

Key words:

Raloxifene

Osteoporosis

Fractures

Breast cancer

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