Metastatic Cervical Carcinoma of Unknown Primary

Remacha, Joan; Castillo, Paola; Vilaseca, Isabel

doi:10.1016/j.otoeng.2021.03.001

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We present a case of a smoker and drinker, who consulted with a cervical tumour of 3 months’ duration. FNA showed metastasis of squamous cell carcinoma with a pattern suggestive of p16+, although limited by the scarce material in the cell block. No tumour was evident in the airway with white light or narrow band light (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Computed tomography and positron emission tomography (<a class="elsevierStyleCrossRef" href="#fig0010">Fig. 2</a>) showed no evidence of primary tumour either. Bilateral palatine and lingual tonsillectomy with lymph node emptying helped detect the tumour.<elsevierMultimedia ident="fig0005"></elsevierMultimedia><elsevierMultimedia ident="fig0010"></elsevierMultimedia>Pathological anatomy confirmed a non-keratinizing squamous cell carcinoma associated with human papillomavirus in the right palatine tonsil (<a class="elsevierStyleCrossRef" href="#fig0015">Fig. 3</a>), A) Panoramic view of H&E staining of a section of the right palatine tonsil. B) Panoramic view of immunohistochemistry against p16, showing intense and diffuse expression highlighting the neoplastic areas. C) Higher magnification view of the carcinoma (H&E 10×), highlighting the endophytic growth and solid nests towards the tonsillar crypts. D) Higher magnification view (10×) of the neoplasm showing positivity for p16 in the tumour nests.<elsevierMultimedia ident="fig0015"></elsevierMultimedia>Histological aspect of the lymph node metastasis (<a class="elsevierStyleCrossRef" href="#fig0020">Fig. 4</a>). A) Panoramic view of H&E staining of a section of the adenopathic conglomerate showing infiltration by non-keratinising cystic squamous cell carcinoma. B) Panoramic view of immunohistochemistry against p16, showing intense and diffuse positivity in the metastatic carcinoma.<elsevierMultimedia ident="fig0020"></elsevierMultimedia>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "Please cite this article as: Remacha J, Castillo P, Vilaseca I. Carcinoma escamoso cervical metastásico de origen desconocido. 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ISSN: 2173-5735

Acta Otorrinolaringológica Española, the official publication of the Spanish Society of Otolaryngology and Head and Neck Surgery and the Ibero-American Society of Otorhinolaryngology, is the most important journal in Spanish dedicated to Otorhinolaryngology, which reflects the continuous scientific and technical progress of the specialty. It has become an important tool to be kept up to date. The Journal publishes Original Articles (articles on basic research and clinical investigation), reviews, brief communications, case studies and images, which are subjected to a rigorous peer review process.

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0.9

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0.326

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Vol. 72. Issue 5.