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Journal Information
Vol. 62. Issue 5.
Pages 355-362 (September - October 2011)
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Vol. 62. Issue 5.
Pages 355-362 (September - October 2011)
Original article
SDHB Expression in Warthin's Tumour
Expresión de SDHB en el tumor de Warthin
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3622
Beatriz Vera-Sireraa,
Corresponding author
vera_fra@gva.es

Corresponding author.
, Judith Pérez-Rojasb, Cecilia López-Valdiviab, Enrique Jiménezb, Diego Collado-Martínc, Francisco Vera-Sempereb,d
a Departamento de Estomatología, Universidad de Valencia, Valencia, Spain
b Servicio de Anatomía Patológica, Hospital Universitario La Fe, Valencia, Spain
c Servicio de Otorrinolaringología, Hospital Universitario La Fe, Valencia, Spain
d Departamento de Patología, Universidad de Valencia, Valencia, Spain
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Tables (2)
Table 1. Warthin's Tumour: Clinical–Pathological Data.
Table 2. Succinate Dehydrogenase B (SDHB) Reactivity in Relation to Clinical Data.
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Abstract
Introduction

Succinic dehydrogenase subunit B (SDHB) is an enzyme belonging to the mitochondrial complex II. The aim of this study is to analyse SDHB expression in a series of Warthin's tumours, studying its relationship with oncocytic changes, constantly present in this form of tumour.

Material and methods

In resection tumour specimens from a series of ten Warthin's tumours (all from the parotid gland), immunohistochemical expression of SDHB was analysed using a commercially available monoclonal antibody.

Results

The Warthin's tumours studied affected 10 men (mean age: 64.2 yrs, range 40–80), all with smoking habits, and 2 with metachronous bilateral involvement. Two patients presented associated urothelial carcinoma. Our SDHB study showed marked reactivity (++/+++) in all cases in the oncocytic epithelial component and also in striated duct cytoplasm (+) from non-tumorous parotid tissue. Expression was not influenced by age, smoking intensity or bilateral character. One of the tumours showed squamous metaplasia foci with SDHB-negativity at this level.

Discussion and conclusions

Due to the constant and intense SDHB reactivity in oncocytic cells in our observations, oncocytic changes are not considered to be associated with defective enzyme activity in the mitochondrial complex II. Strong SDHB reactivity is an additional marker of oncocytic changes in Warthin's tumour. Neither of these facts has been described previously.

Keywords:
SDHB
Warthin's tumour
Oncocytes
Immunohistochemistry
Resumen
Introducción

El objetivo del presente estudio es analizar la expresión de la succinodeshidrogenasa B (SDHB), enzima perteneciente al complejo mitocondrial II, en el tumor de Warthin analizando su relación con los cambios oncocíticos, un dato morfológico constante en este tipo tumoral.

Material y métodos

En una serie de 10 tumores de Warthin, todos parotídeos, se analizó en los especímenes de resección tumoral la expresión de SDHB utilizando un anticuerpo monoclonal comercializado.

Resultados

Los 10 tumores afectaron a 10 varones (edad media: 64, 2 años; rango: 40-80), todos ellos con antecedentes de hábito tabáquico, y 2 con afectación bilateral metacrónica. Dos pacientes presentaron de forma asociada carcinomas del tracto urotelial. El estudio de la SDHB mostró en todos los casos acusada reactividad (++/+++) del componente epitelial oncocítico, así como del citoplasma de los conductos estriados del tejido parotídeo no tumoral. Esta expresión no se vio influida por el rango de edad, la intensidad del hábito tabáquico, ni por el carácter bilateral de los tumores. Uno de los tumores presentó focos de metaplasia escamosa con negatividad a la SDHB en esa localización.

Discusión y conclusiones

La constante e intensa reactividad de la SDHB encontrada en nuestras observaciones, en las células oncocíticas, orienta a considerar que los cambios oncocíticos en el tumor de Warthin no se asocian a una actividad enzimática defectiva en este componente del complejo mitocondrial II. La reactividad de SDHB se conforma como un marcador adicional de la diferenciación oncocítica existente en el caso del tumor de Warthin, aspectos ambos previamente no descritos.

Palabras clave:
SDHB
Tumor de Warthin
Oncocitos
Inmunohistoquímica

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