Evaluation of the hypolipidemic effect of cinnamon essential oil in a model of acute damage induced by triton WR-1339

De la Rosa-García, JM; Cordero-Pérez, P; Jimenéz-Torrés, CA; Garza-Guzman, D; Govea-Torres, GR; Rodríguez-Rodríguez, DR; Torres-González, L; Muñoz-Espinosa, LE; Moreno-Peña, DP

doi:10.1016/j.aohep.2022.100862

ISSN: 1665-2681

Annals of Hepatology (AoH) is an international, open access journal published bi-monthly with funds from the Fundación Clínica Médica Sur. It is the official journal of the Mexican Association of Hepatology (AMH), the Latin American Association for the Study of the Liver (ALEH), the Canadian Association for the Study of the Liver (CASL) and the Czech Society of Hepatology (CSH). AoH publishes editorials, opinions, concise reviews, original articles, brief reports, letters to the editor, news from affiliated associations, clinical practice guidelines and summaries of congresses in the field of Hepatology.

Topics covered by AoH include alcoholic liver disease, autoimmune hepatitis, biliary diseases, drug-induced liver injury, genetic liver diseases, NAFLD/NASH and viral hepatitis (HAV, HBV, HCV, HDV, HEV). Our journal seeks to publish articles on basic clinical care and translational research focused on preventing rather than treating the complications of end-stage liver disease.

See more Open Access Option

Indexed in:

Scopus, Web of Science, Medline/PubMed, DOAJ and Conacyt

Orogastric administration was performed for seven days and subsequently, triton or vehicle was administered intraperitoneally for 24 hours before undergoing sacrifice. The non-toxicity of cinnamon essential oil at a concentration of 200mg/kg, biochemical markers, proinflammatory cytokines and expression of genes associated with oxidative stress and inflammation were evaluated. The trial was approved by the research ethics committee.

Results

No increase in liver enzymes was observed in rats from the group of non-toxicity. Cinnamon essential oil administration significantly reduced cholesterol (COL), triglycerides (TG), and VLDL levels. Regarding the measurement of proinflammatory cytokines and expression of genes related to oxidative stress and inflammation, no effect was observed on these parameters at the evaluated dose of cinnamon essential oil.

Discussion

Cinnamon essential oil treatment showed a significant reduction in COL, TG and VLDL levels, displaying a higher effectivity than atorvastatin. The non-significant results in the levels of cytokines and expression of genes related to oxidative stress and inflammation could be attributed to the acute damage model employed; had more time been given to the model, said makers might have been activated.

Conclusions

The hypolipidemic activity of cinnamon essential oil was demonstrated to be more effective than atorvastatin.

Funding

The resources used in this study were from the hospital without any additional financing

Declaration of interest

The authors declare no potential conflicts of interest.

Full text is only aviable in PDF