P-29 INCIDENCE AND ASSOCIATED FACTORS OF HEPATOCELLULAR CARCINOMA IN PATIENTS WITH CHRONIC HEPATITIS B INFECTION IN A SINGLE CENTER IN PERU: A RETROSPECTIVE STUDY.

Introduction and Objectives

Chronic Hepatitis B infection represents an isolated risk for the development of hepatocellular carcinoma. This study aimed to investigate the incidence of hepatocellular carcinoma and associated factors in patients with chronic Hepatitis B infection with at least 5-year follow-up.

Materials and Methods

Retrospective study. Patients with chronic hepatitis B infection with or without cirrhosis, who were treated at the Liver Unit of the National Hospital Arzobispo Loayza and had at least 5-year follow-up, were enrolled. Predictive scores for hepatocellular carcinoma such as REACH-B, PAGE-B, mPAGE-B, aMAP, CU-HCC, GAG-HCC, and LSM-HCC were calculated at enrollment. The crude and cumulative incidence of hepatocellular carcinoma in the study population was determined.

Results

68 patients, 51.5% were males, and 25% had cirrhosis. The average age was 46.24 years. The incidence of hepatocellular carcinoma was 2.94% with a cumulative incidence of 0.51 person-year. In the univariate analysis, increased liver stiffness (kPa) (OR:1.1 (95% CI: 1.001 - 1.3), p<0.05) and lower albumin (g/dL) was associated with an increased risk of hepatocellular carcinoma.

Conclusions

The incidence of hepatocellular carcinoma was 2.9%. Increased liver stiffness and lower albumin, signs of cirrhosis, were predictive factors of hepatocellular carcinoma.