HLA Class II-DRB1 Alleles with Hepatitis C Virus Infection Outcome in Egypt: A Multicentre Family-based Study
Mahmoud El-Bendary
, Mustafa Neamatallah†, Hatem Elalfy*, Tarek Besheer*, Emily Kamel‡, Hend Mousa§, Abdel-Hamid Eladl||, Maged El-Setouhy¶, Abdel-Hady El-Gilany‡, Ahmed El-Waseef§, Gamal Esmat**
,
Corresponding author
* Tropical Medicine & Hepatology, Mansoura Faculty Of Medicine, Mansoura University, Mansoura,Dakahlyia, Egypt
† Medical Biochemistry, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Dakahlyia, Egypt
‡ Public Health & Preventive Medicine, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Dakahlyia, Egypt
§ Biochemistry, Mansoura Faculty of Science, Mansoura University, Mansoura, Dakahlyia, Egypt
|| Internal Medicine Department, Alazhar Faculty of Medicine-Assiut University, Assiut, Egypt
¶ Department of Community and Occupational Medicine, Ain Shams Faculty of Medicine. Ain Shams University, Cairo, Egypt
** Tropical Medicine & Hepatology, Cairo Faculty of Medicine
Read
2153
Timeswas read the article
509
Total PDF
1644
Total HTML
Share statistics
array:24 [ "pii" => "S1665268119303084" "issn" => "16652681" "doi" => "10.5604/01.3001.0012.7864" "estado" => "S300" "fechaPublicacion" => "2019-01-01" "aid" => "70146" "copyright" => "Fundación Clínica Médica Sur, A.C." "copyrightAnyo" => "2019" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Ann Hepatol. 2019;18:68-77" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 178 "formatos" => array:3 [ "EPUB" => 18 "HTML" => 97 "PDF" => 63 ] ] "itemSiguiente" => array:19 [ "pii" => "S1665268119303096" "issn" => "16652681" "doi" => "10.5604/01.3001.0012.7865" "estado" => "S300" "fechaPublicacion" => "2019-01-01" "aid" => "70147" "copyright" => "Fundación Clínica Médica Sur, A.C." "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Ann Hepatol. 2019;18:78-88" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 176 "formatos" => array:3 [ "EPUB" => 12 "HTML" => 111 "PDF" => 53 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Lysosomal Acid Lipase: Can it be a New Non-Invasive Serum Biomarker of Cryptogenic Liver Fibrosis and Cirrhosis?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "78" "paginaFinal" => "88" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0025" "etiqueta" => "Figure 4" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr4.jpeg" "Alto" => 1436 "Ancho" => 2078 "Tamanyo" => 320867 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Area under the ROC curve (AUROC) of LAL activity and other non-invasive serum biomarkers according to the presence of liver steatosis, significant fibrosis and cirrhosis.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marta Gravito-Soares, Elisa Gravito-Soares, Dario Gomes, Luis Tome" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Marta" "apellidos" => "Gravito-Soares" ] 1 => array:2 [ "nombre" => "Elisa" "apellidos" => "Gravito-Soares" ] 2 => array:2 [ "nombre" => "Dario" "apellidos" => "Gomes" ] 3 => array:2 [ "nombre" => "Luis" "apellidos" => "Tome" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268119303096?idApp=UINPBA00004N" "url" => "/16652681/0000001800000001/v2_201907270857/S1665268119303096/v2_201907270857/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1665268119303072" "issn" => "16652681" "doi" => "10.5604/01.3001.0012.7863" "estado" => "S300" "fechaPublicacion" => "2019-01-01" "aid" => "70145" "copyright" => "Fundación Clínica Médica Sur, A.C." "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Ann Hepatol. 2019;18:58-67" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 278 "formatos" => array:3 [ "EPUB" => 12 "HTML" => 203 "PDF" => 63 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Performance of Serum Glypican 3 in Diagnosis of Hepatocellular Carcinoma: A meta-analysis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "58" "paginaFinal" => "67" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0035" "etiqueta" => "Figure 6" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr6.jpeg" "Alto" => 719 "Ancho" => 2093 "Tamanyo" => 173078 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">Sensitivity analysis plots.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Dahai Xu, Chang Su, Liang Sun, Yuanyuan Gao, Youjun Li" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Dahai" "apellidos" => "Xu" ] 1 => array:2 [ "nombre" => "Chang" "apellidos" => "Su" ] 2 => array:2 [ "nombre" => "Liang" "apellidos" => "Sun" ] 3 => array:2 [ "nombre" => "Yuanyuan" "apellidos" => "Gao" ] 4 => array:2 [ "nombre" => "Youjun" "apellidos" => "Li" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268119303072?idApp=UINPBA00004N" "url" => "/16652681/0000001800000001/v2_201907270857/S1665268119303072/v2_201907270857/en/main.assets" ] "en" => array:17 [ "idiomaDefecto" => true "titulo" => "HLA Class II-DRB1 Alleles with Hepatitis C Virus Infection Outcome in Egypt: A Multicentre Family-based Study" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "68" "paginaFinal" => "77" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Mahmoud El-Bendary, Mustafa Neamatallah, Hatem Elalfy, Tarek Besheer, Emily Kamel, Hend Mousa, Abdel-Hamid Eladl, Maged El-Setouhy, Abdel-Hady El-Gilany, Ahmed El-Waseef, Gamal Esmat" "autores" => array:11 [ 0 => array:4 [ "nombre" => "Mahmoud" "apellidos" => "El-Bendary" "email" => array:1 [ 0 => "mmelbendary@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Mustafa" "apellidos" => "Neamatallah" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">†</span>" "identificador" => "aff0010" ] ] ] 2 => array:3 [ "nombre" => "Hatem" "apellidos" => "Elalfy" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Tarek" "apellidos" => "Besheer" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Emily" "apellidos" => "Kamel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">‡</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "Hend" "apellidos" => "Mousa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">§</span>" "identificador" => "aff0020" ] ] ] 6 => array:3 [ "nombre" => "Abdel-Hamid" "apellidos" => "Eladl" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">||</span>" "identificador" => "aff0025" ] ] ] 7 => array:3 [ "nombre" => "Maged" "apellidos" => "El-Setouhy" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¶</span>" "identificador" => "aff0030" ] ] ] 8 => array:3 [ "nombre" => "Abdel-Hady" "apellidos" => "El-Gilany" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">‡</span>" "identificador" => "aff0015" ] ] ] 9 => array:3 [ "nombre" => "Ahmed" "apellidos" => "El-Waseef" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">§</span>" "identificador" => "aff0020" ] ] ] 10 => array:3 [ "nombre" => "Gamal" "apellidos" => "Esmat" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0035" ] ] ] ] "afiliaciones" => array:7 [ 0 => array:3 [ "entidad" => "Tropical Medicine & Hepatology, Mansoura Faculty Of Medicine, Mansoura University, Mansoura,Dakahlyia, Egypt" "etiqueta" => "*" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Medical Biochemistry, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Dakahlyia, Egypt" "etiqueta" => "†" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Public Health & Preventive Medicine, Mansoura Faculty of Medicine, Mansoura University, Mansoura, Dakahlyia, Egypt" "etiqueta" => "‡" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Biochemistry, Mansoura Faculty of Science, Mansoura University, Mansoura, Dakahlyia, Egypt" "etiqueta" => "§" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Internal Medicine Department, Alazhar Faculty of Medicine-Assiut University, Assiut, Egypt" "etiqueta" => "||" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Department of Community and Occupational Medicine, Ain Shams Faculty of Medicine. Ain Shams University, Cairo, Egypt" "etiqueta" => "¶" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Tropical Medicine & Hepatology, Cairo Faculty of Medicine" "etiqueta" => "**" "identificador" => "aff0035" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondence and reprint request:" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0015" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1177 "Ancho" => 2104 "Tamanyo" => 383495 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Cycle sequencing analysis of exon 2 of HLA-DRB1*11:01:01 allele</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0040">Introduction</span><p id="p0010" class="elsevierStylePara elsevierViewall">Hepatitis C virus (HCV) is a global health problem.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">1</span></a> In 2013 HCV was infecting approximately 2%-3% of the world’s population, with additional 3-4 millions are infected annually.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">2</span></a> Although acute hepatitis C is asymptomatic, HCV persists in about 70%-85% of cases.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">3</span></a> The role of nonsexual HCV interfamilial transmission is controversial. The prevalence of anti-HCV antibodies among household contacts of infected patient was found to be 13.7% in Egypt<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">4</span></a> HCV is slowly progressive disease, as cirrhosis will develop in about 20%-30% of patients within 20 years and 1%-4% of them are at high risk of hepatocellular carcinoma (HCC).<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">5</span></a> The natural history of HCV infection is determined by a complex interaction between host genetic, immunological and viral factors.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">6</span></a></p><p id="p0015" class="elsevierStylePara elsevierViewall">Although HCV elicits innate immune responses early after infection the virus can overcome the immunity and persist. Viral clearance occurs only in the presence of antiviral CD4+ and CD8 + T cell responses.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">7</span></a></p><p id="p0020" class="elsevierStylePara elsevierViewall">The class I and class II human leukocyte antigens (HLA) are ideal candidate genes to study associations between HCV infection and outcomes.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">8</span></a> Specific HLA alleles have been shown to influence the outcome of the HCV infection.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">5</span></a></p><p id="p0025" class="elsevierStylePara elsevierViewall">Class II is composed of three major genes DR, DQ, and DP. HLA-DR is composed of multiple genes and DRB1 is the most polymorphic and important one which gives variation in immune response.<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">8</span></a> A recent study from Egypt reported that the clearance of HCV was associated with DQB1 03:01:01:01 allele while the chronicity of HCV infection was associated with the risk allele: DQB1*02:01:01.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">9</span></a> Several studies reported that HLA-DRB1 alleles may play a critical role in the susceptibility to or clearance from HCV infection and also may determine the response to antiviral drugs.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">8,10,11</span></a></p><p id="p0030" class="elsevierStylePara elsevierViewall">The responsibility of the HLA-DRB1 alleles for the susceptibility to HCV infection is highly variable from one population to another.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">11</span></a></p><p id="p0035" class="elsevierStylePara elsevierViewall">We aimed in this study to investigate the role of HLA-DRBlin HCV infection in large family based study community to avoid any concomitant population stratification or type I error.</p></span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0045">Material and Methods</span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0050">Subjects</span><p id="p0040" class="elsevierStylePara elsevierViewall">This multicenter study was carried out in the Molecular Genetic Unit in Endemic Hepatogastroenterology and Infectious Diseases (MGUHID), Faculty of Medicine, Mansoura University. We investigated Egyptian HCV patients and their families or close household contacts from different Egyptian population representing [Upper Egypt and lower Egypt (including East and West Delta)] Mainly from Dakahlia, Cairo & Assuit governorates between 2011 and 2015. We selected the families on the bases of including at least one positive HCV member (index), one positive for HCV markers and one family member negative for HCV infection or liver complications and disorders. According to these criteria 162 Egyptian families were recruited in this study with a total of 951 individuals (255 infected participants with chronic hepatitis C (CHC), 588 controls (a household contact negative to HCV) and108participants who spontaneously cleared the virus (SVC): i.e with positive Anti-HCV but negative PCR HCV RNA in 2 successive samples at least 6 months apart with no prior history of antiviral therapy. The index cases in the family were selected with inclusion criteria of 1-HCV positive by PCR RNA > 6 months, 2-Adults (above 18 years) of both sexes 3-Any stage of HCV related liver diseases, while exclusion criteria of the index cases were:</p><p id="p0045" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="l0010"><li class="elsevierStyleListItem" id="u0010"><span class="elsevierStyleLabel">•</span><p id="p0050" class="elsevierStylePara elsevierViewall">Patients co-infected with HIV or HBV (HBV core antibodies).</p></li><li class="elsevierStyleListItem" id="u0015"><span class="elsevierStyleLabel">•</span><p id="p0055" class="elsevierStylePara elsevierViewall">Patient with anti-HCV antibodies positive and no detectable PCR-HCV in the serum, also autoimmune hepatitis, HCC and metabolic liver diseases were excluded.</p></li></ul></p><p id="p0060" class="elsevierStylePara elsevierViewall">Healthy control household contacts were included in this study with inclusion criteria of 1-Age > 18 years of both sex, 2-first and second degree consanguinity to the index case living and sharing usual life activity with index case and having at least 15 years of exposure to the index case. 3-serological evidence of HCV, HBV, HCC, and history of liver diseases were excluded. Each participant was subjected to routine clinical and laboratory investigations by one staff clinician in addition to molecular diagnosis and PCR HCV to confirm HCV infection. All the studied cases were subjected to clinical examinations and routine laboratory investigations (complete blood picture, liver function tests).</p><p id="p0065" class="elsevierStylePara elsevierViewall">This study was carried out in accordance with the most recent declaration of Helsinki, and each participant signed a written informed consent before participating in the study. The study was reviewed and approved by the Research Ethics Committee (REC) of the Faculty of Medicine, Mansoura University, Egypt.</p></span><span id="s0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0055">Methods</span><p id="p0070" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="l0015"><li class="elsevierStyleListItem" id="u0020"><span class="elsevierStyleLabel">•</span><p id="p0075" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">HCV-PCR</span>.</span> Viral RNA was extracted from serum using Qiagen RNA extraction kit (QIA amp® DNA Blood kit (QIAGEN GmbH; Hilden’s, Germany) according to manufacturer instructions. Extracted HCV RNA samples were quantitatively by real time PCR (Applied Biosystem, Foster City, CA, USA, 7,500 real time PCR system) that determine the viral load of the samples. Sero-negative HCV-Ab were pooled and centrifuged at 15,000 rpm for 60 min. Supernatant was discarded and the pellet was resuspended in 150 <span class="elsevierStyleItalic">j</span>L of supernatant and extracted for viral RNA.</p></li><li class="elsevierStyleListItem" id="u0025"><span class="elsevierStyleLabel">•</span><p id="p0080" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">DNA extraction</span>.</span> Genomic DNA was extracted from peripheral blood cells using a DNA extraction kit (QIAmp DNA Mini kit; Qiagen, Hilden’s, Germany)according to manufacturer instructions. Extracted DNA were assessed by using NanoDropTM (NanoDrop™2000/2000c spectrophotometer, Thermo Scientific, USA)</p></li><li class="elsevierStyleListItem" id="u0030"><span class="elsevierStyleLabel">•</span><p id="p0085" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">HLA-DRB1 typing</span>.</span> Low and high resolution typing combine in this complete, two-step system for HLA-DRB1 typing research. The 9 ready-reaction PCR mixes provide high specificity amplification using allele group-specific primers for exon 2 of HLA-DRB1. The PCR products are subsequently sequenced to generate high-resolution allele assignments.</p><p id="p0090" class="elsevierStylePara elsevierViewall">The second exon of HLA-DRB1 gene was typed using sequence based typing (SBT). For HLA-DRB1exon 2 alleles sequencing, amplification was first done using specific sequence primer pair (Qiagen kit). The PCR reaction was done using a thermal cycler (Applied Biosystems, 2720). A cycle sequence was performed for the purified PCR product in the forward direction by the forward primer using Big Dye TM terminator Cycle sequencing kits (versions 3.0) according to manufacturer’s protocol. Sequenced products were then separated by capillary electrophoresis using an Applied Biosystems 310 Genetic Analyzer. Sequences were analyzed with dedicated software.</p></li><li class="elsevierStyleListItem" id="u0035"><span class="elsevierStyleLabel">•</span><p id="p0095" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic"><span class="elsevierStyleBold">HLA genotyping analysis</span>.</span> This consensus sequences were compared against the appropriate library of HLA alleles (www.ebi.ac.uk/ipd/imgt/hla/blast.html) and (http://blast.ncbi.nlm.nih.gov)) to obtain the results of specific allele sequence.</p></li></ul></p></span><span id="s0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0060">Statistical analysis</span><p id="p0100" class="elsevierStylePara elsevierViewall">Data were computed and statistically analyzed using SPSS software program. (IBM Corp. Released 2012. IBM SPSS Statistics for Windows, Version 21.0. Armonk, NY: IBM Corp). For comparison of qualitative variables (presented as frequencies and percentages) %<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">2</span></a> of Fisher Exact test were used. Hardy Weinberg equilibrium (HWE) was assessed in each group separately using %<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">2</span></a> tests. The allele carriage is defined as the number of individuals carrying at least one copy of a specific allele. Allelic frequencies are defined as the number of occurrences of the test allele divided by the total number of alleles in the group. Odds ratio at 95% confidence interval (CI) of specific allele carriage was calculated compared with the non-carriage of target allele using Med Calc software(Med Calc statistical software version 16.4.3. Med Calc (software bvba, Ostend,Belgium; https://www.medcalc.org; 2016). The difference was considered significant if P < 0.05. OR and confidence interval was calculated using two by two contingency table by comparing the allele carriage of at least one copy of this allele in different groups. If OR and 95 %CI is greater than 1. It mean this allele is a risk one. The allele is considered as protective allele if OR and 95% CI is less than one. The p value statistic of OR was adjusted using Bonferroni formula (P<span class="elsevierStyleInf">C</span> corrected) The Bonferroni corrected-p value is an adjustment made to P values when several dependent or independent statistical tests are being performed simultaneously on a single data set.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">12</span></a></p></span></span><span id="s0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0065">Results</span><p id="p0105" class="elsevierStylePara elsevierViewall">The laboratory charateristics of the studied groups are shown in <a class="elsevierStyleCrossRef" href="#t0010">table 1</a>.</p><elsevierMultimedia ident="t0010"></elsevierMultimedia><span id="s0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0070">Descriptive genetic analysis data for HLA-DRB1 alleles</span><p id="p0110" class="elsevierStylePara elsevierViewall">Genetic analysis data for HLA-DQB1 alleles in <a class="elsevierStyleCrossRef" href="#t0015">table 2</a> showed that the Matching Probability, Power of Discrimination, PIC (polymorphic information content), Homozygotes, Heterozygotes rates showed no significant differences between, chronic HCV(CHC), control and SVC groups. The analysis showed that the PIC for CHC, control subjects and SVC group ranged from (0.70 to 0.91) and heterozygosity ranged from (73.14 to 90.58) which indicates that this locus is highly polymorphic enough to do statistical analysis in Egyptians.</p><elsevierMultimedia ident="t0015"></elsevierMultimedia></span><span id="s0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0075">Allele frequency and allele carriage of HLA-DRB1 alleles in different groups</span><p id="p0115" class="elsevierStylePara elsevierViewall">Analysis of the frequency of HLA-DRB1 alleles in CHC, control, and SVC groups revealed that DRB1*13:01:01 (26.07%) (<a class="elsevierStyleCrossRef" href="#f0010">Figure 1</a>) is the most frequent allele in positive cases, followed by DRB1* 13:02:01 and DRB1*03:01:01 (25.29%) (<a class="elsevierStyleCrossRef" href="#f0010">Figure 1</a>). In control, DRB1*11:01:01 is the most frequent allele (14.88%) followed by DRB1*3:01:01 (13.1%) and DRB1*07:01:01 (10.88%). In SVC group, DRB1*11:01:01 (20.37%) is the most frequent allele (<a class="elsevierStyleCrossRef" href="#f0015">Figure 2</a>), followed by DRB1*1:01:01 (13.89%) and DRB1*03:01:01 (12.04%) wh ile other alleles showed less equal frequencies (<a class="elsevierStyleCrossRef" href="#t0020">Table 3</a>).</p><elsevierMultimedia ident="f0010"></elsevierMultimedia><elsevierMultimedia ident="f0015"></elsevierMultimedia><elsevierMultimedia ident="t0020"></elsevierMultimedia><p id="p0120" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#t0025">Table 4</a>, comparing the distribution of HLA-DRB1 alleles between CHC, control and SVC groups revealed that: The carriage of allele 3:01:01 was significant in C HC group wh en compared to that of control and SVC groups (OR = 5.1289, 95% CI: 3.8570 to 6.8225, <span class="elsevierStyleItalic">p</span> = 0.001; and OR = 5.9847, 95% CI: 3.6217 to 9.8896, <span class="elsevierStyleItalic">P <</span> 0.000, 1 <span class="elsevierStyleItalic">P<span class="elsevierStyleInf">c</span></span> = 0.0006) respectively. The carriage of allele 13:01:01 was significantly higher in CHC group when compared to control and SVC groups. After Bonferroni correction the result remain significant (OR = 4.6860, CI: 3.3702 to 6.5156, <span class="elsevierStyleItalic">P</span> < 0.0001 <span class="elsevierStyleItalic">P<span class="elsevierStyleInf">c</span></span> = 0.0006 and OR = 6.5987, CI: 3.5159 to 12.3846, <span class="elsevierStyleItalic">P</span> = 0.0001, <span class="elsevierStyleItalic">Pc</span> = 0.0006) respectively. On the other hand, DRB1 *040501 and DRB1* 110101 alleles were more frequent in both control and SVC groups more than in CHC patients (for DRB1 *04051 OR = 0.4052 CI: 0.2543 to 0.6456, <span class="elsevierStyleItalic">P</span> = 0.0001, <span class="elsevierStyleItalic">P<span class="elsevierStyleInf">c</span></span> = 0.0006 and OR = 0.4061, CI: 0.2165 to 0.7620 <span class="elsevierStyleItalic">P</span> = 0.005, <span class="elsevierStyleItalic">P<span class="elsevierStyleInf">c</span></span> = 0.03 respectively. For DRB1*110101 OR = 0.2169, CI: 0.1345 to 0.3498, <span class="elsevierStyleItalic">p</span> = 0.0001, <span class="elsevierStyleItalic">P<span class="elsevierStyleInf">c</span></span> = 0.0006 and OR = 0.1739, CI: 0.0965 to 0.3135, <span class="elsevierStyleItalic">P</span> < 0.0001 <span class="elsevierStyleItalic">P<span class="elsevierStyleInf">c</span></span> = 0.0001 respectively). While DRB1*040101 was statistically significant in SVC group when compared to both CHC & control groups (OR = 0.0916, CI: 0.0299 to 0.2812, <span class="elsevierStyleItalic">P</span> = 0.0001, <span class="elsevierStyleItalic">P<span class="elsevierStyleInf">c</span></span> = 0.0006 and OR = 0.2130, CI: 0.1072 to 0.4232, <span class="elsevierStyleItalic">P</span> = 0.0001, <span class="elsevierStyleItalic">Pc</span> = 0.0006). The carriage of alleles 7 family (7:01:01) was found to be significantly higher in both control and SVC groups when both were compared to CHC group even after Bonferroni correction the results remain significant (OR = 0.1833, CI: 0.0970 to 0.3464 <span class="elsevierStyleItalic">P</span> < 0.0001, <span class="elsevierStyleItalic">P<span class="elsevierStyleInf">c</span></span> = 0.0006 and OR = 0.2592, CI: 0.1160 to 0.5794, <span class="elsevierStyleItalic">P</span> = 0.001, <span class="elsevierStyleItalic">P<span class="elsevierStyleInf">c</span></span> = 0.006 respectively). Also no significant association was found when a comparison was made between control and SVC group (OR = 1.4744, CI: 0.8359 to 2.6006, <span class="elsevierStyleItalic">P</span> = 0.1883).</p><elsevierMultimedia ident="t0025"></elsevierMultimedia></span></span><span id="s0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0080">Discussion</span><p id="p0125" class="elsevierStylePara elsevierViewall">HCV is a major health problem in Egypt affecting more than 10% of the population.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">2</span></a> Interplay between host and environmental factors are major determinants of HCV infection outcome.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">13</span></a> A number of baseline factors were reported as independent predictors for HCV infection<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">14,15</span></a> including, low viral load, HCV genotype, absence of co infection as well as the host immunogenetic factors including human leukocyte antigen (HLA-DRB1) alleles.<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">7,16</span></a></p><p id="p0130" class="elsevierStylePara elsevierViewall">Polymorphism in the peptide binding regions of HLA-DR molecules determines antigenic specificities and strength of immune response to a given pathogen. It is well known that HLA-DRB1 alleles are crucial factors regulating cellular and humoral immune response through producing HLA-DR molecules participating in presentation of viral antigens on the surface of antigen presenting cells to CD4 + T cells.<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">17,18</span></a> Genes of DR may determine HCV infection outcome and are prominent immunogenic factors influencing response to interferon treatment.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">19</span></a> The presence of specific HLA-DRB1 alleles may affect the HCV infection but associations vary among populations and results are controversial.<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">3,20</span></a></p><p id="p0135" class="elsevierStylePara elsevierViewall">To the best of our knowledge, this study is the first multicentre one to test the association between HLA-DRB1 alleles and HCV infection outcome among the Egyptian families.</p><p id="p0140" class="elsevierStylePara elsevierViewall">Studies of the relations between human leukocyte antigens and HCV infection showed inconsistent results. This inconstancy may be due to improper diagnosis and classification of the disease, population stratification, ethnic variation, or inadequate sample sizes.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">11</span></a> Another cause may be due to comparing the studied groups either (persistence of infection group or virus clearance group) with healthy control only.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">21</span></a> The problem of using healthy control subject is that about 80% of these subjects when exposed for the first time to HCV will develop chronicity while the rest showed spontaneous viral clearance (SVC).To overcome this inconstancy, subjects with Spontaneous viral clearance (SVC) should be compared to subjects with persistence of infection (CHC).<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">3</span></a></p><p id="p0145" class="elsevierStylePara elsevierViewall">Comparing the distribution of HLA-DRB1 alleles between CHC and other 2 groups revealed that the carriage of alleles 3:01:01 and 13:01:01 were significantly higher in CHC compared to control and SVC groups (i.e. These alleles associated with persistence of HCV infection).</p><p id="p0150" class="elsevierStylePara elsevierViewall">On the other hand, DRB1*04:01:01, DRB1*04:05:01, DRB1*7:01:01 and DRB1*11:01:01 alleles were more frequent in SVC group when compared to CHC patients (i.e. These alleles associated with protection against HCV infection).</p><p id="p0155" class="elsevierStylePara elsevierViewall">These results are consistent with previous results from different ethnic groups. In Caucasian American and in large multiracial cohort of U.S. women viral persistence was associated with DRB1*0301.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">11,22</span></a></p><p id="p0160" class="elsevierStylePara elsevierViewall">Several studies conducted in Italian neonates, Spanish Irish, Northern European Caucasoid (NEC), France, Thailand and Indian populations showed that DRB1*03 was associated with persistence of HCV infection.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">8,19,23-27</span></a> On the other hand HLA-DRB1*11 seems to be protective against the development of severe forms of HCV infection in Spanish, Italian neonates, France and UK.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">19,28-30</span></a> Whereas in Japanese DRB1*1101 was more frequently found in carriers with persistently normal ALT values than in patients with CLD.<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">31</span></a></p><p id="p0165" class="elsevierStylePara elsevierViewall">A German study of North Europeans found that DRB1*13 was associated with susceptibility to HCV infection.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">32</span></a> However another study revealed that HLA-DRB1*11 allele was associated with a reduced risk for the development of HCV induced end stage liver disease.<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">33</span></a></p><p id="p0170" class="elsevierStylePara elsevierViewall">A meta-analysis carried on by Yee, <span class="elsevierStyleItalic">et al.</span> 2004 involving Caucasian population only from the period of 1997-2002 concluded that DRB1*11 was associated with protection against HCV infection.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">13,26,27,34-37</span></a> But these studies are generally smaller in size, less conclusive and performed with low resolution techniques.</p><p id="p0175" class="elsevierStylePara elsevierViewall">In China it was found that DRB1*1101 was a protective allele and subjects with this allele are at a lower risk of developing chronic HCV.<a class="elsevierStyleCrossRef" href="#bib0195"><span class="elsevierStyleSup">38</span></a></p><p id="p0180" class="elsevierStylePara elsevierViewall">In Brazilian population it was confirmed that there were higher frequencies of HLA-DRB1*13 in patients compared with controls while DRB1*11was associated with protection from chronic HCV infection.<a class="elsevierStyleCrossRefs" href="#bib0200"><span class="elsevierStyleSup">39,40</span></a> Also in Pakistan and Iran DRB1*11 was associated with viral clearance.<a class="elsevierStyleCrossRefs" href="#bib0210"><span class="elsevierStyleSup">41,42</span></a> While in Iraq, it was found that the presence of DRB1*11 was significantly associated with increased risk for HCV infection.<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">43</span></a></p><p id="p0185" class="elsevierStylePara elsevierViewall">Reports from Egypt addressed that HLA-DRB1*03 individually or in combination with HLA-DRB1*04 act as a protective alleles against HCV infection.<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">44</span></a> While In Egyptian HCV infected children it was reported that the most frequent alleles demonstrated among patients were DRB1 *03, DRB1 *04 and DRB1 *13 while DRB1*15 was significantly reduced among patients when compared with the control group.<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">45</span></a> Shaker, <span class="elsevierStyleItalic">et al.</span> 2013 found that DRB1*04 and DRB1*11 were significantly more frequent in non responders than in responders. In contrast, DRB1*13 and DRB1*15 alleles were significantly more frequent in responders than in non responders. However this study compared the patients with the healthy control group not to the SVC group making these results inconsistent.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">10</span></a></p><p id="p0190" class="elsevierStylePara elsevierViewall">There are other studies found that other HLA-DRB1 alleles were associated with the susceptibility to HCV infection. The frequency of DRB1*0405 was higher in HCV-infected patients than in uninfected subjects in Japan,<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">31</span></a> whereas DRB1*1302 was more frequently found in carriers with persistently normal ALT values than in patients with CLD.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">3</span></a></p><p id="p0195" class="elsevierStylePara elsevierViewall">Different studies carried on populations with different ethnic origin showed that the virus clearance was associated with the DRB1*1 and DRB1*13 in Caucasians (European and Americans) and with DRB1*12 in Non-Caucasian Americans.<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">46</span></a> While the susceptibility to infection was connected to DRB1*3 and DRB1*7 in Caucasians (European and Americans) and to DRB1*12 in Caucasians Americans only. In a Midwestern American cohort reported the associations of DRB1*12 with HCV infection.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">21</span></a> Furthermore in Taiwan population it was suggested that DRB1*12 was significantly associated with the risk of HCC.<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">47</span></a> In contradiction to these results, it was found that interaction between the KIR receptor gene 2DL3 with HLA-DRB1*1201 was associated with SVC.<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">48</span></a></p><p id="p0200" class="elsevierStylePara elsevierViewall">Several reports from different ethnic origin in the world reported that DRB1*07 allele was linked to viral persistence of HCV infection. (in British, Polish,Italian, Brazilian, Mid western Americans and Pakistanian populations.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">19,21,27,39,41,49</span></a> On the other hand in Iranian and Thailand HCV infected patient DRB1*0701 allele was found to be significantly presented in patients with HCV clearance.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">24,42</span></a></p><p id="p0205" class="elsevierStylePara elsevierViewall">DRB1*01 is associated with viral clearance in a large multiracial cohort of U.S. women with a high prevalence of HCV and HIV.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">22</span></a> Same results were reported in white subjects and in Swiss Cohor, but another investigators reported that DRB1*1001 was associated with disease.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">27</span></a></p><p id="p0210" class="elsevierStylePara elsevierViewall">Conflicting reports as regard DRB1*08 were recorded, whereas DRB1*0803 in Korean patients was associated with chronic HCV carriers,<a class="elsevierStyleCrossRef" href="#bib0255"><span class="elsevierStyleSup">50</span></a> in Tunisian patients it was associated with clearance of circulating HCV.<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">51</span></a></p><p id="p0215" class="elsevierStylePara elsevierViewall">The frequency of DRB1*15 was associated with SVC but in Tunisian patients it appears to predispose to progression of liver disease.<a class="elsevierStyleCrossRef" href="#bib0260"><span class="elsevierStyleSup">51</span></a></p><p id="p0220" class="elsevierStylePara elsevierViewall">In conclusion, the present study suggested that certain HLA-DRB1 alleles namely DRB1*03:01:01 and DRB1* 13:01:01 may act as a risk alleles for HCV persistence while DRB1*04:01:01, DRB1*04:05:01, DRB1*7:01:01 and DRB1*11:01:01 alleles were associated with HCV clearance in the Egyptian families. This is important for disease management and deciding which person would most likely susceptible to HCV infection and which would not. It is strongly recommended that further investigations are needed to study more associations of these factors which may affect HCV susceptibility in the Egyptian population which may help towards eradication of HCV.</p></span><span id="s0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0085">Acknowledgement</span><p id="p0225" class="elsevierStylePara elsevierViewall">We would like to thank Medical Biochemistry department &xMedical Expreimental Research Centre (MERC)-Mansoura Faculty of Medicine, Mansoura University for their kind help & support to complete routine laboratory work.</p></span><span id="s0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0090">Abbreviations</span><p id="p0230" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="l0020"><li class="elsevierStyleListItem" id="u0040"><span class="elsevierStyleLabel">•</span><p id="p0235" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">Ab</span>: antibody.</p></li><li class="elsevierStyleListItem" id="u0045"><span class="elsevierStyleLabel">•</span><p id="p0240" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">AFP</span>. alpha feto protein.</p></li><li class="elsevierStyleListItem" id="u0050"><span class="elsevierStyleLabel">•</span><p id="p0245" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">CHC</span>: chronic hepatitis C.</p></li><li class="elsevierStyleListItem" id="u0055"><span class="elsevierStyleLabel">•</span><p id="p0250" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">CI</span>: confidence interval.</p></li><li class="elsevierStyleListItem" id="u0060"><span class="elsevierStyleLabel">•</span><p id="p0255" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">CV</span>: chronic viraemia.</p></li><li class="elsevierStyleListItem" id="u0065"><span class="elsevierStyleLabel">•</span><p id="p0260" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">ELISA</span>: enzyme linked immune sorbont assay.</p></li><li class="elsevierStyleListItem" id="u0070"><span class="elsevierStyleLabel">•</span><p id="p0265" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HBV</span>: hepatitis B virus.</p></li><li class="elsevierStyleListItem" id="u0075"><span class="elsevierStyleLabel">•</span><p id="p0270" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HCC</span>: hepatocellular carcinoma.</p></li><li class="elsevierStyleListItem" id="u0080"><span class="elsevierStyleLabel">•</span><p id="p0275" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HCV</span>: hepatitis C virus.</p></li><li class="elsevierStyleListItem" id="u0085"><span class="elsevierStyleLabel">•</span><p id="p0280" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HIV</span>: human immundefeciency virus.</p></li><li class="elsevierStyleListItem" id="u0090"><span class="elsevierStyleLabel">•</span><p id="p0285" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HLA</span>: human leukocyte antigen.</p></li><li class="elsevierStyleListItem" id="u0095"><span class="elsevierStyleLabel">•</span><p id="p0290" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HWE</span>: hardy weinberg equilibrium.</p></li><li class="elsevierStyleListItem" id="u0100"><span class="elsevierStyleLabel">•</span><p id="p0295" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">LC</span>: liver cirrhosis.</p></li><li class="elsevierStyleListItem" id="u0105"><span class="elsevierStyleLabel">•</span><p id="p0300" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">MHC</span>: major histocompatibility complex.</p></li><li class="elsevierStyleListItem" id="u0110"><span class="elsevierStyleLabel">•</span><p id="p0305" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">OR</span>: odd</p></li><li class="elsevierStyleListItem" id="u0115"><span class="elsevierStyleLabel">•</span><p id="p0310" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">PC</span>: bonferroni correction.</p></li><li class="elsevierStyleListItem" id="u0120"><span class="elsevierStyleLabel">•</span><p id="p0315" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">SBT</span>: sequence-based typing.</p></li><li class="elsevierStyleListItem" id="u0125"><span class="elsevierStyleLabel">•</span><p id="p0320" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">SCV</span>: spontaneously cleared the virus.</p></li><li class="elsevierStyleListItem" id="u0130"><span class="elsevierStyleLabel">•</span><p id="p0325" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">SSP-PCR</span>: sequence specific primer-polymerase chain reaction.</p></li><li class="elsevierStyleListItem" id="u0135"><span class="elsevierStyleLabel">•</span><p id="p0330" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">UV</span>: ultra violet.</p></li><li class="elsevierStyleListItem" id="u0140"><span class="elsevierStyleLabel">•</span><p id="p0335" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">VC</span>: viral clearance.</p></li></ul></p></span><span id="s0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0095">Conflict of Interest</span><p id="p0340" class="elsevierStylePara elsevierViewall">The authors declares that there is no conflict of interest regarding the publication of this article.</p></span><span id="s0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0100">Financial Support</span><p id="p0345" class="elsevierStylePara elsevierViewall">This research was funded by Science & Technology Development Foundation (STDF), Project NO.1784 (TC/2/Health/2009/hep-1.3).</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:11 [ 0 => array:3 [ "identificador" => "xres1224785" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abs0010" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1138851" "titulo" => "Key words" ] 2 => array:2 [ "identificador" => "s0010" "titulo" => "Introduction" ] 3 => array:3 [ "identificador" => "s0015" "titulo" => "Material and Methods" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "s0020" "titulo" => "Subjects" ] 1 => array:2 [ "identificador" => "s0025" "titulo" => "Methods" ] 2 => array:2 [ "identificador" => "s0030" "titulo" => "Statistical analysis" ] ] ] 4 => array:3 [ "identificador" => "s0035" "titulo" => "Results" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "s0040" "titulo" => "Descriptive genetic analysis data for HLA-DRB1 alleles" ] 1 => array:2 [ "identificador" => "s0045" "titulo" => "Allele frequency and allele carriage of HLA-DRB1 alleles in different groups" ] ] ] 5 => array:2 [ "identificador" => "s0050" "titulo" => "Discussion" ] 6 => array:2 [ "identificador" => "s0055" "titulo" => "Acknowledgement" ] 7 => array:2 [ "identificador" => "s0060" "titulo" => "Abbreviations" ] 8 => array:2 [ "identificador" => "s0065" "titulo" => "Conflict of Interest" ] 9 => array:2 [ "identificador" => "s0070" "titulo" => "Financial Support" ] 10 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2017-06-06" "fechaAceptado" => "2017-12-11" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec1138851" "palabras" => array:4 [ 0 => "HCV susceptibility" 1 => "HLA-DRB1 polymorphism" 2 => "virus clearance" 3 => "intrafamilial" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abs0010" class="elsevierStyleSection elsevierViewall"><p id="sp0040" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Introduction and aim</span>. Hepatitis C virus (HCV) infection is a global medical problem. HLA -DRB1 alleles have an important role in immune response against HCV. The aim of this study is to clarify the contribution of HLA -DRB1 alleles in HCV susceptibility in a multicentre family-based study.</p><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Material and methods</span>. A total of 162 Egyptian families were recruited in this study with a total of 951 individuals (255 with chronic hepatitis C (CHC), 588 persons in the control group(-ve household contact to HCV) and 108 persons who spontaneously cleared the virus (SVC). All subjects were genotyped for HLA -DRB1 alleles by SSP-PCR and sequence based typing (SBT) methods.</p><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results</span>. The carriage of alleles 3:01:01 and 13:01:01 were highly significant in CHC when compared to that of control and SVC groups [OR of 3 family = 5.1289, <span class="elsevierStyleItalic"><span class="elsevierStyleBold">P<span class="elsevierStyleInf">C</span></span></span> (Bonferroni correction ) = 0.0002 and 5.9847, <span class="elsevierStyleItalic"><span class="elsevierStyleBold">P<span class="elsevierStyleInf">C</span></span></span> = 0.0001 and OR of 13 family = 4.6860, <span class="elsevierStyleItalic"><span class="elsevierStyleBold">P<span class="elsevierStyleInf">C</span></span></span> = 0.0002 and OR = 6.5987, <span class="elsevierStyleItalic"><span class="elsevierStyleBold">P<span class="elsevierStyleInf">C</span></span></span> = 0.0001 respectively]. While DRB1*040501, DRB1*040101, DRB1*7:01:01 and DRB1*110101 alleles were more frequent in SVC group than CHC patients (OR = 0.4052, <span class="elsevierStyleItalic"><span class="elsevierStyleBold">P<span class="elsevierStyleInf">C</span></span></span> = 0.03, OR: OR = 0.0916,<span class="elsevierStyleItalic"><span class="elsevierStyleBold">P<span class="elsevierStyleInf">C</span></span></span> = 0.0006, OR = 0.1833,<span class="elsevierStyleItalic"><span class="elsevierStyleBold">P<span class="elsevierStyleInf">C</span></span></span> = 0.0006 and OR = 0.4061, <span class="elsevierStyleItalic"><span class="elsevierStyleBold">P<span class="elsevierStyleInf">C</span></span></span> = 0.0001 respectively).</p><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Conclusions</span>. It was concluded that among the Egyptian families, HLA-DRB1*030101, and DRB1*130101 alleles associated with the risk of progression to CHC infection, while DRB1*040101, DRB1*040501, DRB1*7:01:01and DRB1*110101 act as protective alleles against HCV infection.</p></span>" ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "f0010" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1146 "Ancho" => 2075 "Tamanyo" => 424781 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall">Cycle sequencing analysis of exon 2 of HLA-DRB1*:03:01:01 & HLA-DRB1*:13:01:01alleles.</p>" ] ] 1 => array:7 [ "identificador" => "f0015" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1177 "Ancho" => 2104 "Tamanyo" => 383495 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Cycle sequencing analysis of exon 2 of HLA-DRB1*11:01:01 allele</p>" ] ] 2 => array:8 [ "identificador" => "t0010" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "<span class="elsevierStyleItalic">S. bilirubin (N: < 1.1 mg/dL). S. albumin (N 3.9-5.1 g/dL). SGOT (aspartate aminotransferase) (N < 40 IU/L). (SGPT) alanine aminotransferase (N < 45 !U/L). ALP: alkaline phosphatase (N: 37-116 U/L). Alpha fetoprotein (AFP) (N < 10 ng/mL): antinuclear antibodies (ANA) (N < 1.1 U). S. creatinine (N < 1.4 mg/dL). S. cholesterol (N < 200 mg/dL). CHC: chronic hepatitis C. SVC: spontaneous virus clearance.</span>" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Positive group (CHC) (255) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Control group (588) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Spontaneous clearance(SVC) (108) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="top">Sex</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">M \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">185 (72.22%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">277 (47.11%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">71 (65.74%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">F \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">70 (27.78%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">311 (52.89%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">37 (34.26%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Parameters \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Mean (±SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Mean (±SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Mean (±SD) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">41.5 (13.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">36.7 (22.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">43 (10.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">S. bilirubin (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.6 (0.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.8 (0.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.85 (0.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">S. albumin (gm/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.8 (0.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.4 (0.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.3 (0.44) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SGOT (IU/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">49 (10) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">22 (5.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">SGPT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">52 (11) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 (8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 (4.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ALP U/L \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">77.8 (15.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">55 (18.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">62 (18.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AFP ng/mL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25 (16.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (3.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.2 (4.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ANA (U) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.7 (0.18) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.6 (0.25) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5 (0.18) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">S. creatinin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.8 (0.35) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.6 (0.39) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9 (0.18) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">S. cholesterol \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">157 (25.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">149 (24.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">166 (21.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2092135.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Clinical & laboratory characteristics of studied groups.</p>" ] ] 3 => array:8 [ "identificador" => "t0015" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "PIC: polymorphic information content. CHC: chronic hepatitis C. SVC: spontaneous virus clearance." "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Genetic analysis data \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">All subjects \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">(CHC) Positive group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Negative Control group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Spontaneous clearance (SVC) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Power of discrimination \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.956 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.872 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.981 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PIC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.84 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.912 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Homozygotes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.3 % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9.42 % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.65 % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26.86% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Heterozygotes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">84.7 % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">90.58 % \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">84.35% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">73.14% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hardy-Weinberg \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">X<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.75212 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.16124 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.3267 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.0047 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><span class="elsevierStyleItalic">P</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.3858 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.14069 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.567609 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.08157 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2092133.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0025" class="elsevierStyleSimplePara elsevierViewall">Descriptive genetic analysis data of HLA-DRB1 alleles in different groups</p>" ] ] 4 => array:8 [ "identificador" => "t0020" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "<span class="elsevierStyleItalic">In each cell; the upper numbers represent the carriage number of homozygous/ carriage number of heterozygous; The lower number represents the allele frequency. Total positive = index cases + positive relative.</span>" "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Alleles \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total (951) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Index (162) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Relative positive (93) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total positive(CHC) (255) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Negative control (588) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Spontaneous clearance(SVC) (108) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16/77 5.73% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/13 4.01% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/2 1.07% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/15 2.941% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12/40 5.44% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4/22 13.89% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14/281 16.25% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/77 25.62% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/42 24.73% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5/119 25.29% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7/140 13.1% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/22 12.04% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/38 2.31% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/4 1.23% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/0 0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/4 0.78% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/19 1.96% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/15 7.87% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4:05:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8/158 9.15% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/16 4.94% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/8 4.3% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/24 4.71% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5/115 10.63% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/19 11.57% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12/135 8.36% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/5 1.54% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/6 3.22% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/11 2.15% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8/112 10.88% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4/12 9.25% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7:03:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/38/ 2.31% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/1 0.31% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/0 0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/1 0.19% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/33 2.81% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/4 4.63% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7:05:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/11 0.58% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/0 0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/0 0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/0 0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/9 0.76% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/2 0.92% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7:07:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/29 0.63% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/1 0.31% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/2 1.07% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/3 0.58% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/24 2.21% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/2 0.92% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8:02:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/76 3.99% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/2 0.62% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/6 3.22% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/8 15.69% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/64 5.44% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/4 1.85% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/81 4.57% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/9 2.78% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/1 0.538% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/10 1.96% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/70 6.46% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/1 0.463% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/13 0.684% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/1 0.31% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/8 4.30% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/9 1.76% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/2 0.17% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/2 0.926% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25/193 12.77% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/11 4% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1/9 5.91% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/20 4.7% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17/141 14.88% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6/32 20.37% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">12:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/9 0.47% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/2 0.62% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/1 0.53% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/3 0.58% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/6 0.51% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/0 0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">31/198 13.66% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5/74 25.93% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/39 24.19% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8/113 25.29% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">21/74 9.86% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2/11 6.94% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13:02:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">29/182 12.61% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6/74 26.54% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3/41 25.26% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9/115 26.07% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16/57 7.56% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4/10 8.33% \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/15 0.78% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/3 0.93% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/1 0.53% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/4 0.78% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/11 0.93% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/0 0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15:02:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/66 3.47% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/1 0.31% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/1 0.53% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/2 0.39% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/64 5.44% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/0 0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/12 0.64% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/0 0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/1 0.53% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/1 0.19% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/11 0.93% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0/0 0 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2092134.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0030" class="elsevierStyleSimplePara elsevierViewall">Allele carriages and allele frequencies of DRB1 Loci in different study groups.</p>" ] ] 5 => array:8 [ "identificador" => "t0025" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "OR: odds Rrtio. CI: confidence interval. vs. versus. Pc: P(<span class="elsevierStyleInf">corrected</span> or Bonferroni correction. Bonferroni correction was applied when P < 0.05, Risk allele If OR and CI > 1.0 and Pc < 0.05. Protective allele If OR and Ci < 1.0 and Pc < 0.05." "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Allele \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Positive(CHC) vs. negative control</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Positive(CHC) vs. spontaneous (SVC)</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Spontaneous clearance(SVC) vs. negative control</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OR (95% CI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">P(Pc) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OR (95 % CI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">P(Pc) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OR (95 % CI) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">P(Pc) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">03:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.1298 (3.8570 to 6.8225) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0001 (0.0006) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.9847 (3.6217 to 9.8896) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0001 (0.0006) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.1667 (0.7143 to 1.9054) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.5380 NA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">04:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.4303 (0.1462 to 1.2665) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.1257 NA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0916 (0.0299 to 0.2812) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0001 (0.0006) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.2130 (0.1072 to 0.4232) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0001 (0.0006) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">04:05:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.4052 (0.2543 to 0.6456) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">< 0.0001 0.0006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.4061 (0.2165 to 0.7620) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0050 0.0300 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0023 (0.6022 to 1.6682) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.9929 NA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">07:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.1833 (0.0970 to 0.3464) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0001 (0.0006) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.2592 (0.1160 to 0.5794) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0010 (0.0060) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.4744 (0.8359 to 2.6006) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.1883 NA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.2169 (0.1345 to 0.3498) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0001 0.0006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.1739 (0.0965 to 0.3135) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">< 0.0001 (0.0006) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.8019 (0.5166 to 1.2445) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.3248 NA \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13:01:01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.6860 (3.3702 to 6.5156) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.0001 (0.0006) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.5987 (3.5159 to 12.3846) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">< 0.0001 (0.0006) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.4082 (0.7577 to 2.6172) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.2791 NA \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2092132.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0035" class="elsevierStyleSimplePara elsevierViewall">Odds ratio of common allele of DRB1 Locus in different study groups.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bs0010" "bibliografiaReferencia" => array:51 [ 0 => array:3 [ "identificador" => "bib0010" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Global Distribution and Prevalence of Hepatitis C Virus Genotypes." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Messina J.P." 1 => "Humphreys I." 2 => "Flaxman A." 3 => "Brown A." 4 => "Cooke G.S." 5 => "Pybus O.G." 6 => "Barnes E." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Hepatology (Baltimore, Md)" "fecha" => "2015" "volumen" => "61" "paginaInicial" => "77" "paginaFinal" => "87" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0015" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Burden of pediatric hepatitis C." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "El-Shabrawi M.H." 1 => "Kamal N.M." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3748/wjg.v19.i44.7880" "Revista" => array:6 [ "tituloSerie" => "World J Gastroenterol" "fecha" => "2013" "volumen" => "19" "paginaInicial" => "7880" "paginaFinal" => "7888" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24307782" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0020" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Host genetic determinants in hepatitis C virus infection." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Yee L.J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.gene.6364090" "Revista" => array:6 [ "tituloSerie" => "Genes Immun" "fecha" => "2004" "volumen" => "5" "paginaInicial" => "237" "paginaFinal" => "245" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15103322" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0025" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiological Aspects of Intrafamilial Spread of HCV Infection in Egyptian Population: A Pilot Study." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "El-Bendary M." 1 => "Esmat G." 2 => "Neamatallah M." 3 => "Kamel E." 4 => "Besheer T." 5 => "Elalfy H." 6 => "El-Setouhy M." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Open J Gastroenterol" "fecha" => "2014" "volumen" => "4" "paginaInicial" => "228" "paginaFinal" => "236" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0030" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Urabe Y." 1 => "Ochi H." 2 => "Kato N." 3 => "Kumar V." 4 => "Takahashi A." 5 => "Muroyama R." 6 => "Hosono N." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jhep.2012.12.024" "Revista" => array:6 [ "tituloSerie" => "J Hepatol" "fecha" => "2013" "volumen" => "58" "paginaInicial" => "875" "paginaFinal" => "882" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23321320" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0035" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Host and Viral Determinants of the Outcome of Exposure to HCV Infection Genotype 4: A Large Longitudinal Study." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Kamal S.M." 1 => "Kassim S.K." 2 => "Ahmed A.I." 3 => "Mahmoud S." 4 => "Bahnasy K.A." 5 => "Hafez T.A." 6 => "Aziz I.A." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ajg.2013.427" "Revista" => array:6 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2014" "volumen" => "109" "paginaInicial" => "199" "paginaFinal" => "211" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24445571" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0040" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Host factors affecting the outcome of treatment of hepatitis C." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Bruno R." 1 => "Sacchi P." 2 => "Maiocchi L." 3 => "Zocchetti C." 4 => "Filice G." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Rev Gastroenterol Disord" "fecha" => "2004" "volumen" => "4" "numero" => "Suppl. 1" "paginaInicial" => "S3" "paginaFinal" => "S7" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15580150" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0045" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of HLA alleles with hepatitis C infection in Maharashtra, western India." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Tripathy A.S." 1 => "Shankarkumar U." 2 => "Chadha M.S." 3 => "Ghosh K." 4 => "Arankalle V.A." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Indian J Med Res" "fecha" => "2009" "volumen" => "130" "paginaInicial" => "550" "paginaFinal" => "555" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20090103" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0050" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Associations of human leucocyte antigen class II-DQB1 alleles with hepatitis C virus infection in Egyptian population: a multicentre family-based study." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "El-Bendary M." 1 => "Neamatallah M." 2 => "Esmat G." 3 => "Kamel E." 4 => "Elalfy H." 5 => "Besheer T." 6 => "Eldeib D." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/jvh.12573" "Revista" => array:6 [ "tituloSerie" => "Journal of Viral Hepatitis" "fecha" => "2016" "volumen" => "23" "paginaInicial" => "961" "paginaFinal" => "970" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/27599887" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0055" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human Leukocyte Antigen Class II Alleles (DQB1 and DRB1) as Predictors for Response to Interferon Therapy in HCV Genotype 4." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Shaker O." 1 => "Bassiony H." 2 => "El Raziky M." 3 => "El-Kamary S." 4 => "Esmat G." 5 => "ElGhor A.M." 6 => "Mohamed M." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:4 [ "titulo" => "Mediat Inflamm" "paginaInicial" => "1" "paginaFinal" => "10" "serieFecha" => "2013" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0060" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Racial differences in HLA class II associations with hepatitis C virus outcomes." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Thio C.L." 1 => "Thomas D.L." 2 => "Goedert J.J." 3 => "Vlahov D." 4 => "Nelson K.E." 5 => "Hilgartner M.W." 6 => "O'Brien S.J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/321005" "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "2001" "volumen" => "184" "paginaInicial" => "16" "paginaFinal" => "21" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11398104" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0065" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "What's wrong with Bonferroni adjustments." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Perneger T.V." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/bmj.316.7139.1236" "Revista" => array:6 [ "tituloSerie" => "BMJ" "fecha" => "1998" "volumen" => "316" "paginaInicial" => "1236" "paginaFinal" => "1238" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9553006" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0070" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genes of the major histocompatibility complex class II influence the outcome of hepatitis C virus infection." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Alric L." 1 => "Fort M." 2 => "Izopet J." 3 => "Vinel J.P." 4 => "Charlet J.P." 5 => "Selves J." 6 => "Puel J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/gast.1997.v113.pm9352872" "Revista" => array:6 [ "tituloSerie" => "Gastroenterology" "fecha" => "1997" "volumen" => "113" "paginaInicial" => "1675" "paginaFinal" => "1681" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9352872" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0075" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiological characteristics and response to peginterferon plus ribavirin treatment of hepatitis C virus genotype 4 infection." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Roulot D." 1 => "Bourcier V." 2 => "Grando V." 3 => "Deny P." 4 => "Baazia Y." 5 => "Fontaine H." 6 => "Bailly F." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2893.2006.00823.x" "Revista" => array:6 [ "tituloSerie" => "J Viral Hepat" "fecha" => "2007" "volumen" => "14" "paginaInicial" => "460" "paginaFinal" => "467" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17576387" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0080" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictors of a sustained virological response in patients with genotype 4 chronic hepatitis C." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Gad R.R." 1 => "Males S." 2 => "El Makhzangy H." 3 => "Shouman S." 4 => "Hasan A." 5 => "Attala M." 6 => "El Hoseiny M." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1478-3231.2008.01750.x" "Revista" => array:6 [ "tituloSerie" => "Liver Int" "fecha" => "2008" "volumen" => "28" "paginaInicial" => "1112" "paginaFinal" => "1119" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18397226" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0085" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Antigen Specific Cellular Response in Patients with Hepatitis C Virus Infection and its Association with HLA Alleles." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Mahapatra C." 1 => "Tripathy A.S." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "IJCRIMPH" "fecha" => "2011" "volumen" => "3.3" "paginaInicial" => "273273" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25834646" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0090" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HLA class II disease associations in southern Africa." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Lombard Z." 1 => "Brune A.E." 2 => "Hoal E.G." 3 => "Babb C." 4 => "Van Helden P.D." 5 => "Epplen J.T." 6 => "Bornman L." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1399-0039.2006.00530.x" "Revista" => array:7 [ "tituloSerie" => "Tissue Antigens" "fecha" => "2006" "volumen" => "67" "paginaInicial" => "97" "paginaFinal" => "110" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16441480" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0212698210001886" "estado" => "S300" "issn" => "02126982" ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0095" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HLA DR-DQ combination associated with the increased risk of developing human HCV positive non-Hodgkin's lymphoma is related to the type II mixed cryoglobulinemia." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "De Re V." 1 => "Caggiari L." 2 => "Monti G." 3 => "Libra M." 4 => "Spina M." 5 => "Dolcetti R." 6 => "De Zorzi M." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1399-0039.2009.01414.x" "Revista" => array:6 [ "tituloSerie" => "Tissue Antigens" "fecha" => "2010" "volumen" => "75" "paginaInicial" => "127" "paginaFinal" => "135" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20002609" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0100" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comparative review of HLA associations with hepatitis B and C viral infections across global populations." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Singh R." 1 => "Kaul R." 2 => "Kaul A." 3 => "Khan K." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3748/wjg.v13.i12.1770" "Revista" => array:6 [ "tituloSerie" => "World J Gastroenterol" "fecha" => "2007" "volumen" => "13" "paginaInicial" => "1770" "paginaFinal" => "1787" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17465466" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0105" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Response to interferon therapy: influence of human leucocyte antigen alleles in patients with chronic hepatitis C." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Sim H." 1 => "Wojcik J." 2 => "Margulies M." 3 => "Wade J.A." 4 => "Heathcote J." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Viral Hepat" "fecha" => "1998" "volumen" => "5" "paginaInicial" => "249" "paginaFinal" => "253" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9751011" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0110" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ethnic and geographical differences in HLA associations with the outcome of hepatitis C virus infection." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Wang J.H." 1 => "Zheng X." 2 => "Ke X." 3 => "Dorak M.T." 4 => "Shen J." 5 => "Boodram B." 6 => "O'Gorman M." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1743-422X-6-46" "Revista" => array:5 [ "tituloSerie" => "Virol J" "fecha" => "2009" "volumen" => "6" "paginaInicial" => "46" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19409091" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib0115" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Specific Human Leukocyte Antigen Class I and II Alleles Associated with Hepatitis C Virus Viremia." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Kuniholm M.H." 1 => "Kovacs A." 2 => "Gao X.J." 3 => "Xue X.N." 4 => "Marti D." 5 => "Thio C.L." 6 => "Peters M.G." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Hepatology (Baltimore, Md)" "fecha" => "2010" "volumen" => "51" "paginaInicial" => "1514" "paginaFinal" => "1522" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib0120" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The MHC is a major determinant of viral status, but not fibrotic stage, in individuals infected with hepatitis C." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "McKiernan S.M." 1 => "Hagan R." 2 => "Curry M." 3 => "McDonald G.S." 4 => "Nolan N." 5 => "Crowley J." 6 => "Hegarty J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0016-5085(00)70365-9" "Revista" => array:6 [ "tituloSerie" => "Gastroenterology" "fecha" => "2000" "volumen" => "118" "paginaInicial" => "1124" "paginaFinal" => "1130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10833487" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib0125" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HLA association with hepatitis C virus infection." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Vejbaesya S." 1 => "Songsivilai S." 2 => "Tanwandee T." 3 => "Rachaibun S." 4 => "Chantangpol R." 5 => "Dharakul T." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hum Immunol" "fecha" => "2000" "volumen" => "61" "paginaInicial" => "348" "paginaFinal" => "353" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10689128" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib0130" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human leukocyte antigen class II alleles may contribute to the severity of hepatitis C virus-related liver disease." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Hue S." 1 => "Cacoub P." 2 => "Renou C." 3 => "Halfon P." 4 => "Thibault V." 5 => "Charlotte F." 6 => "Picon M." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/341086" "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "2002" "volumen" => "186" "paginaInicial" => "106" "paginaFinal" => "109" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12089669" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib0135" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "McKiernan S.M." 1 => "Hagan R." 2 => "Curry M." 3 => "McDonald G.S." 4 => "Kelly A." 5 => "Nolan N." 6 => "Walsh A." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Hepatology (Baltimore, Md)" "fecha" => "2004" "volumen" => "40" "paginaInicial" => "108" "paginaFinal" => "114" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib0140" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HLA class I B44 is associated with sustained response to interferon + ribavirin therapy in patients with chronic hepatitis C." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Romero-Gomez M." 1 => "Gonzalez-Escribano M.F." 2 => "Torres B." 3 => "Barroso N." 4 => "Montes-Cano M.A." 5 => "Sanchez-Munoz D." 6 => "Nunez-Roldan A." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1572-0241.2003.07537.x" "Revista" => array:6 [ "tituloSerie" => "Am J Gastroenterol" "fecha" => "2003" "volumen" => "98" "paginaInicial" => "1621" "paginaFinal" => "1626" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12873589" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib0145" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between MHC class II alleles and clearance of circulating hepatitis C virus." "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "Trent Hepatitis C Virus Study Grp" "etal" => false "autores" => array:6 [ 0 => "Minton E.J." 1 => "Smillie D." 2 => "Neal K.R." 3 => "Irving W.L." 4 => "Underwood J.CE." 5 => "James V." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/515599" "Revista" => array:6 [ "tituloSerie" => "J Infect Dis" "fecha" => "1998" "volumen" => "178" "paginaInicial" => "39" "paginaFinal" => "44" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9652421" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib0150" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of MHC class II genotype on outcome of infection with hepatitis C virus." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Thursz M." 1 => "Yallop R." 2 => "Goldin R." 3 => "Trepo C." 4 => "Thomas H.C." 5 => "Grp H." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0140-6736(99)91443-5" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1999" "volumen" => "354" "paginaInicial" => "2119" "paginaFinal" => "2124" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10609818" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib0155" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extended human leukocyte antigen haplotype EH18.1 influences progression to hepatocellular carcinoma in patients with hepatitis C virus infection." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Lopez-Vazquez A." 1 => "Rodrigo L." 2 => "Mina-Blanco A." 3 => "Martinez-Borra J." 4 => "Fuentes D." 5 => "Rodriguez M." 6 => "Perez R." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1086/382189" "Revista" => array:7 [ "tituloSerie" => "J Infect Dis" "fecha" => "2004" "volumen" => "189" "paginaInicial" => "957" "paginaFinal" => "963" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14999597" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1043276016300418" "estado" => "S300" "issn" => "10432760" ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib0160" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Influence of HLA haplotypes on the clinical courses of individuals infected with hepatitis C virus." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Kuzushita N." 1 => "Hayashi N." 2 => "Moribe T." 3 => "Katayama K." 4 => "Kanto T." 5 => "Nakatani S." 6 => "Kaneshige T." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Hepatology (Baltimore, Md)" "fecha" => "1998" "volumen" => "27" "paginaInicial" => "240" "paginaFinal" => "244" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib0165" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical impact of HLA DR B1 genotypes in chronic hepatitis C virus infection." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Kallinowski B." 1 => "Scherer S." 2 => "Mehrabi A." 3 => "Theilmann L." 4 => "Stremmel W." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0041-1345(99)00820-9" "Revista" => array:6 [ "tituloSerie" => "Transplantation proceedings" "fecha" => "1999" "volumen" => "31" "paginaInicial" => "3346" "paginaFinal" => "3349" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10616501" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib0170" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Low frequency of HLADRB1*11 in hepatitis C virus induced end stage liver disease." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Tillmann H.L." 1 => "Chen D.F." 2 => "Trautwein C." 3 => "Kliem V." 4 => "Grundey A." 5 => "Berning-Haag A." 6 => "Boker K." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/gut.48.5.714" "Revista" => array:7 [ "tituloSerie" => "Gut" "fecha" => "2001" "volumen" => "48" "paginaInicial" => "714" "paginaFinal" => "718" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11302974" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S221385871470169X" "estado" => "S300" "issn" => "22138587" ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib0175" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Decreased frequency of the HLADRB1 *11 allele in patients with chronic hepatitis C virus infection." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Yenigun A." 1 => "Durupinar B." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1128/jvi.76.4.1787-1789.2002" "Revista" => array:6 [ "tituloSerie" => "J Virol" "fecha" => "2002" "volumen" => "76" "paginaInicial" => "1787" "paginaFinal" => "1789" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11799174" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib0180" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Viral clearance in hepatitis C (1b) infection: relationship with human leukocyte antigen class II in a homogeneous population." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Fanning L.J." 1 => "Levis J." 2 => "Kenny-Walsh E." 3 => "Wynne F." 4 => "Whelton M." 5 => "Shanahan F." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Hepatology (Baltimore, Md)" "fecha" => "2000" "volumen" => "31" "paginaInicial" => "1334" "paginaFinal" => "1337" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib0185" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Study of the association between major histocompatibility complex class II genes and the response to interferon alpha in patients with chronic hepatitis C infection." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Alric L." 1 => "Izopet J." 2 => "Fort M." 3 => "Vinel J-P" 4 => "Fontenelle P." 5 => "Orfila C." 6 => "Payen J-L" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Hum Immunol" "fecha" => "1999" "volumen" => "60" "paginaInicial" => "516" "paginaFinal" => "523" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10408801" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib0190" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human leukocyte antigen class II and III alleles and severity of hepatitis C virus-related chronic liver disease." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Asti M." 1 => "Martinetti M." 2 => "Zavaglia C." 3 => "Cuccia M.C." 4 => "Gusberti L." 5 => "Tinelli C." 6 => "Cividini A." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Hepatology (Baltimore, Md)" "fecha" => "1999" "volumen" => "29" "paginaInicial" => "1272" "paginaFinal" => "1279" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib0195" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Human leukocyte antigen class II DQB1 * 0301, DRB1 * 1101 alleles and spontaneous clearance of hepatitis C virus infection: a meta-analysis." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Hong X." 1 => "Yu R-B" 2 => "Sun N-X" 3 => "Wang B." 4 => "Xu Y-C" 5 => "Wu G-L" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3748/wjg.v11.i46.7302" "Revista" => array:6 [ "tituloSerie" => "World J Gastroenterol" "fecha" => "2005" "volumen" => "11" "paginaInicial" => "7302" "paginaFinal" => "7307" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16437632" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib0200" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Distribution of the human leukocyte antigen class II alleles in Brazilian patients with chronic hepatitis C virus infection." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "Corghi D.B." 1 => "Goncales N.S." 2 => "Marques S.B." 3 => "Goncales F.L. Jr" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1590/s0100-879x2008005000041" "Revista" => array:6 [ "tituloSerie" => "Braz J Med Biol Res" "fecha" => "2008" "volumen" => "41" "paginaInicial" => "884" "paginaFinal" => "889" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18925312" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib0205" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HLA Class II Alleles and Chronic Hepatitis C Virus Infection." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Cangussu L.OF." 1 => "Teixeira R." 2 => "Campos E.F." 3 => "Rampim G.F." 4 => "Mingoti S.A." 5 => "Martins O.A." 6 => "Gerbase-DeLima M." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1365-3083.2011.02568.x" "Revista" => array:6 [ "tituloSerie" => "Scand J Immunol" "fecha" => "2011" "volumen" => "74" "paginaInicial" => "282" "paginaFinal" => "287" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21535077" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib0210" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patient HLA-DRB1* and -DQB1* allele and haplotype association with hepatitis C virus persistence and clearance." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Ali L." 1 => "Mansoor A." 2 => "Ahmad N." 3 => "Siddiqi S." 4 => "Mazhar K." 5 => "Muazzam A.G." 6 => "Qamar R." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1099/vir.0.018119-0" "Revista" => array:6 [ "tituloSerie" => "J Gen Virol" "fecha" => "2010" "volumen" => "91" "paginaInicial" => "1931" "paginaFinal" => "1938" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20392899" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib0215" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of HLA class II alleles with hepatitis C virus clearance and persistence in thalassemia patients from Iran." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Samimi-Rad K." 1 => "Sadeghi F." 2 => "Amirzargar A." 3 => "Eshraghian M.R." 4 => "Alavian S.M." 5 => "Rahimnia R." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jmv.24211" "Revista" => array:6 [ "tituloSerie" => "J Med Virol" "fecha" => "2015" "volumen" => "87" "paginaInicial" => "1565" "paginaFinal" => "1572" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25970464" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib0220" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Hasan A-RS, Al-Ajeeli KSA. Association of Hepatitis C Virus (HCV) Infection and Human Leukocyte Antigens (HLA). Diyala Journal of Medicine 2: 53-9." ] ] ] 43 => array:3 [ "identificador" => "bib0225" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Could Human Leukocyte Antigens (HLA) be Predictive Factors to Interferon Response among Chronic Hepatitis C Virus Hepatitis?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "Shaala A." 1 => "Harfoush R." 2 => "ElKhouly E." 3 => "Ahmed M." 4 => "Morsi M." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "J Med Microbiol Diagnos" "fecha" => "2012" "volumen" => "S1" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib0230" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The association of HLA class II DR B1 alleles with HCV infection in Egyptian children." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Yosry A." 1 => "Fouad R." 2 => "Mahmoud S." 3 => "El-Raziky M.S." 4 => "El-Hennawy A." 5 => "Ghoneim M.A." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arab J Gatroenterol" "fecha" => "2011" "volumen" => "12" "paginaInicial" => "25" "paginaFinal" => "28" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib0235" "etiqueta" => "46." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HCV infection and its association with HLA alleles" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Shankarkumar A." 1 => "Shankarkumar U." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "International Journal of Life Sciences Biotechnology and Pharma Research" "fecha" => "2012" "volumen" => "1" "paginaInicial" => "10" "paginaFinal" => "19" ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib0240" "etiqueta" => "47." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between HLA-DRB1 alleles polymorphism and hepatocellular carcinoma: a meta-analysis." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Lin Z.H." 1 => "Xin Y.N." 2 => "Dong Q.J." 3 => "Wang Q." 4 => "Jiang X.J." 5 => "Zhan S.H." 6 => "Sun Y." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1471-230X-10-145" "Revista" => array:6 [ "tituloSerie" => "Bmc Gastroenterol" "fecha" => "2010" "volumen" => "10" "paginaInicial" => "145" "paginaFinal" => "155" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21172035" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib0245" "etiqueta" => "48." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interaction of NK inhibitory receptor genes with HLA-C and MHC class II alleles in Hepatitis C virus infection outcome." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Romero V." 1 => "Azocar J." 2 => "Zuniga J." 3 => "Clavijo O.P." 4 => "Terreros D." 5 => "Gu X." 6 => "Husain Z." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.molimm.2008.01.002" "Revista" => array:6 [ "tituloSerie" => "Molecular Immunology" "fecha" => "2008" "volumen" => "45" "paginaInicial" => "2429" "paginaFinal" => "2436" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18289678" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib0250" "etiqueta" => "49." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HLA class II genotypes associated with chronic hepatitis C virus infection and response to alpha-interferon treatment in Poland." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "Wawrzynowicz-Syczewska M." 1 => "Underhill J.A." 2 => "Clare M.A." 3 => "Boron-Kaczmarska A." 4 => "McFarlane I.G." 5 => "Donaldson P.T." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Liver" "fecha" => "2000" "volumen" => "20" "paginaInicial" => "234" "paginaFinal" => "239" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10902974" "web" => "Medline" ] ] ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib0255" "etiqueta" => "50." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between human leukocytes antigen alleles and chronic hepatitis C virus infection in the Korean population." "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:7 [ 0 => "Yoon S.K." 1 => "Han J.Y." 2 => "Pyo C.W." 3 => "Yang J.M." 4 => "Jang J.W." 5 => "Kim C.W." 6 => "Im Chang U." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1478-3231.2005.01105.x" "Revista" => array:6 [ "tituloSerie" => "Liver International" "fecha" => "2005" "volumen" => "25" "paginaInicial" => "1122" "paginaFinal" => "1127" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16343061" "web" => "Medline" ] ] ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib0260" "etiqueta" => "51." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clearance and persistence of hepatitis C virus in a Tunisian population: association with HLA class I and class II." "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:7 [ 0 => "Ksiaa L." 1 => "Ayed-Jendoubi S." 2 => "Sfar I." 3 => "Gorgi Y." 4 => "Najjar H.A." 5 => "Abdallah T.B." 6 => "Ayed K." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1089/vim.2006.0060" "Revista" => array:6 [ "tituloSerie" => "Viral Immunol" "fecha" => "2007" "volumen" => "20" "paginaInicial" => "312" "paginaFinal" => "319" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17603847" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/0000001800000001/v2_201907270857/S1665268119303084/v2_201907270857/en/main.assets" "Apartado" => array:4 [ "identificador" => "77721" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/16652681/0000001800000001/v2_201907270857/S1665268119303084/v2_201907270857/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268119303084?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 0 | 3 |
| 2024 October | 35 | 7 | 42 |
| 2024 September | 41 | 5 | 46 |
| 2024 August | 29 | 7 | 36 |
| 2024 July | 38 | 7 | 45 |
| 2024 June | 36 | 6 | 42 |
| 2024 May | 53 | 9 | 62 |
| 2024 April | 34 | 8 | 42 |
| 2024 March | 40 | 8 | 48 |
| 2024 February | 47 | 13 | 60 |
| 2024 January | 19 | 10 | 29 |
| 2023 December | 27 | 11 | 38 |
| 2023 November | 22 | 4 | 26 |
| 2023 October | 24 | 5 | 29 |
| 2023 September | 10 | 6 | 16 |
| 2023 August | 15 | 5 | 20 |
| 2023 July | 13 | 2 | 15 |
| 2023 June | 24 | 10 | 34 |
| 2023 May | 41 | 9 | 50 |
| 2023 April | 42 | 3 | 45 |
| 2023 March | 36 | 1 | 37 |
| 2023 February | 25 | 4 | 29 |
| 2023 January | 17 | 3 | 20 |
| 2022 December | 31 | 8 | 39 |
| 2022 November | 37 | 11 | 48 |
| 2022 October | 26 | 14 | 40 |
| 2022 September | 21 | 9 | 30 |
| 2022 August | 23 | 6 | 29 |
| 2022 July | 18 | 15 | 33 |
| 2022 June | 29 | 10 | 39 |
| 2022 May | 24 | 11 | 35 |
| 2022 April | 29 | 11 | 40 |
| 2022 March | 37 | 11 | 48 |
| 2022 February | 31 | 7 | 38 |
| 2022 January | 70 | 2 | 72 |
| 2021 December | 30 | 14 | 44 |
| 2021 November | 47 | 11 | 58 |
| 2021 October | 35 | 10 | 45 |
| 2021 September | 21 | 9 | 30 |
| 2021 August | 22 | 9 | 31 |
| 2021 July | 13 | 5 | 18 |
| 2021 June | 12 | 7 | 19 |
| 2021 May | 18 | 8 | 26 |
| 2021 April | 70 | 22 | 92 |
| 2021 March | 31 | 4 | 35 |
| 2021 February | 18 | 5 | 23 |
| 2021 January | 13 | 9 | 22 |
| 2020 December | 16 | 13 | 29 |
| 2020 November | 28 | 9 | 37 |
| 2020 October | 16 | 5 | 21 |
| 2020 September | 12 | 8 | 20 |
| 2020 August | 17 | 8 | 25 |
| 2020 July | 20 | 10 | 30 |
| 2020 June | 15 | 8 | 23 |
| 2020 May | 15 | 9 | 24 |
| 2020 April | 20 | 2 | 22 |
| 2020 March | 5 | 1 | 6 |
| 2020 February | 12 | 6 | 18 |
| 2020 January | 21 | 9 | 30 |
| 2019 December | 15 | 4 | 19 |
| 2019 November | 6 | 3 | 9 |
| 2019 October | 11 | 5 | 16 |
| 2019 September | 10 | 4 | 14 |
| 2019 August | 5 | 4 | 9 |
| 2019 July | 5 | 4 | 9 |
| 2019 June | 11 | 15 | 26 |
| 2019 May | 7 | 11 | 18 |
Show all
