Ursodeoxycholic Acid Therapy in Patients with Primary Biliary Cholangitis with Limited Liver Transplantation Availability

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Abdominal CT scan verified a heterogeneous cystic mass that represented germinative membrane residues and some daughter vesicles. The intimate relation between the cyst and the right biliary tree can also be seen, specifically with its anterior branches. The biliary communication at this level (segment VI) gave rise to cholangiohydatidosis and secondary acute cholangitis." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carlos Manterola, Tamara Otzen" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Carlos" "apellidos" => "Manterola" ] 1 => array:2 [ "nombre" => "Tamara" "apellidos" => "Otzen" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S166526811930417X?idApp=UINPBA00004N" "url" => "/16652681/0000001600000003/v1_201905301200/S166526811930417X/v1_201905301200/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1665268119304156" "issn" => "16652681" "doi" => "10.5604/01.3001.0009.8597" "estado" => "S300" "fechaPublicacion" => "2017-05-01" "aid" => "70237" "copyright" => "Fundación Clínica Médica Sur, A.C." 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Survival probabilities estimates by Kaplan-Meier method, in five years of follow-up of CBP patients treated with UDCA and others drugs vs. OT without UDCA. B. Adjusted survival curves obtained from a Cox Proportional Hazard Model by treatment (OT vs. UDCA) and letting Mayo Score Risk be the mean value (6.3) and female gender." ] ] ] "textoCompleto" => "IntroductionPrimary biliary cholangitis (PBC) is an autoimmune liver disease characterized by progressive destruction of intrahepatic bile ducts, which may lead to biliary cirrhosis, portal inflammation, and liver failure.<a class="elsevierStyleCrossRefs" href="#bib0010">1,2</a> Ursodeoxycholic acid (UDCA) is the only drug approved by the U.S. Food and Drug Administration to treat PBC, with a recommended dosage of 13-15 mg/kg/day.<a class="elsevierStyleCrossRefs" href="#bib0010">1-3</a> The use of obeti-cholic acid is on the horizon.<a class="elsevierStyleCrossRef" href="#bib0025">4</a>It has been suggested that UDCA treatment improved the serum liver test results, slowed the histological progress, and improved patients’ survival without an orthotropic liver transplant.<a class="elsevierStyleCrossRefs" href="#bib0030">5,6</a> However, the effect of UDCA on survival is still controversial.<a class="elsevierStyleCrossRefs" href="#bib0040">7,8</a>At present, studies on PBC have mostly been carried out in Asia, Europe, Australia, and North America, in developed countries with liver transplant programs for PBC.<a class="elsevierStyleCrossRefs" href="#bib0015">2,5-8</a> However, there is little information about PBC in Latin America. Currently, there are no studies in Mexico or other countries in Latin America that evaluate the medium-term effect of UDCA treatment on survival of patients with PBC.The aim of this study was to compare survival rates of patients in developing countries with PBC using UDCA versus survival rates of patients who received other drugs (OT) prescribed before the UDCA era.Material and MethodsPatientsA retrospective study was performed in the Department of Pathology of the National Institute of Medical Sciences and Nutrition Salvador Zubiran in Mexico City, included patients diagnosed with PBC between 1971 and 2011. All patients who were included had histological and biochemical evidence of cholestasis based mainly on nonsuppurative destructive cholangitis and destruction of interlobular bile ducts, alkaline phosphatase (ALP) elevation at least 1.5 times the upper limit normal (ULN), and presence of positive antimitochondrial antibody (AMA). Exclusion criteria were features suggestive of other coexistent liver diseases, including overlap syndrome, alcoholic liver disease, a positive serological test for hepatitis B or C, non-alcoholic stea-tohepatitis, and hepatocellular carcinoma. The histological stage was assessed using Ludwig criteria: portal hepatitis, bile duct abnormalities, or both are present (stage 1), Peri-portal fibrosis is present, with or without periportal inflammation (stage 2), bridging fibrosis or necrosis or both (stage 3), and cirrhosis (stage 4).<a class="elsevierStyleCrossRef" href="#bib0050">9</a>The following parameters were obtained from medical records: age, gender, associated diseases, symptoms, and liver function test [serum bilirubin levels, albumin, pro-thrombin time, alkaline phospatase (ALP), alanine ami-notransferase (ALT), aspartate aminotransferase (AST)]. Results of liver function tests were recorded at baseline, one month and one year after starting the treatment. The cut-off points used were: ALP 120 U/L as the upper limit of normal (ULN), 35 U/L for AST and ALT, and 1.0 mg/ dL for bilirubin. The lower limit of normal (LLN) for albumin was 3.5 g/dL.<a class="elsevierStyleCrossRef" href="#bib0055">10</a> Patients had received UDCA (15 mg/kg/per day) since 1992 and before other drugs (OT) as colchicine (n = 28), cholestyramine (n = 18), penicilla-mine (n = 7), azathioprine (n = 5), or prednisolone (n = 13), at standard doses. In some cases, patients received more than one drug.Ethical aspectsThis study was approved by the Ethics Board of the National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico. The study protocol conforms to the ethical guidelines of the 1975 Declaration of Helsinki as reflected in a priori approval by the institution's human research committee.Statistical analysesIn descriptive analyses, data are expressed as means ± standard deviation, and percentages. Categorical variables were compared by %<a class="elsevierStyleCrossRef" href="#bib0015">2</a> test among both groups and continuous variables by Student t-test. A paired t test was used to compare means before and after one month of treatment. The biochemical response to UDCA or OT was evaluated by comparing proportion of treatment response at one month and at one year after treatment, according to Barcelona criteria (decrease in ALP > 40% of the baseline level or normal level), Paris criteria (ALP level < 3 ULN, together with AST level < 2 ULN and a normal bilirubin level), Rotterdam criteria (normal bilirubin and albumin concentrations when one or both parameters were abnormal before treatment, or normal bilirubin or albumin concentrations after treatment when both were abnormal at entry), and Toronto criteria (ALP level < 1.76 ULN).<a class="elsevierStyleCrossRef" href="#bib0015">2</a>,<a class="elsevierStyleCrossRef" href="#bib0060">11</a>Survival analysis was used: The follow-up started from the date at histological diagnosis of PBC, time zero (t0), and the end point was liver-related death. Time at event was calculated. Patients who did not present the event was censored at the end of the study, also was censored patients who died from causes unrelated to liver failure and patients that were lost at follow-up; also were censored patients referred for liver transplantation at the moment of OLT. Liver-related death was defined as death due to liver failure or death occurring within two months of an episode of variceal bleeding, spontaneous bacterial peritonitis, hepatorenal syndrome, or hepatic encephalopathy.<a class="elsevierStyleCrossRef" href="#bib0065">12</a>Probabilities of survival were estimated by the Kaplan-Meier method. For the univariate analyses, we compared the survival functions of categorical variables using the log-rank test. To compare survival by continuous variables, Cox proportional hazard regression model with one only variable was used.Multivariate analysis to evaluate the associations between treatments received and the survival function of patients with CBP was done using Cox proportional-hazard risk regression models. Variables with p value less than 0.20 at univariate analysis were included in the multivaria-ble analyses; and in the final model, variables statistically associated with the risk of death or important confounder variables were included.<a class="elsevierStyleCrossRef" href="#bib0070">13</a> Model assumptions and good fit were tested. The analysis was performed using the statistical software STATA (version 12.0, STATA Corporation, College Station, TX, USA).ResultsBaseline characteristicsA total of 78 patients matched by age and sex were included: 41 in the UDCA Group and 37 in the OT Group. When comparing the baseline characteristics of the treatment groups (<a class="elsevierStyleCrossRef" href="#t0010">Table 1</a>), a higher concentration of bilirubin and higher Mayo Risk Score were found in the OT group and respect liver damage, in UDCA group fibrosis (n = 20/41) and cirrhosis (n = 5/41) ; and in OT group fibrosis (n = 13/38) and cirrhosis (n = 10/38) was found.<elsevierMultimedia ident="t0010"></elsevierMultimedia>Treatment responseAfter one month of treatment, an intragroup comparison of UDCA group showed a significant reduction in ALP, total bilirubin, AST, and ALT concentration; no difference with statistical significance was observed in the OT group (<a class="elsevierStyleCrossRef" href="#t0015">Table 2</a>). Furthermore, when comparisons after one month post-treatment between groups were done, total bilirubin (ULN) was statistically different; it was higher in the OT group (2.1 ± 2.3 vs. 5.7 ± 6.0, p = 0.007).<elsevierMultimedia ident="t0015"></elsevierMultimedia><a class="elsevierStyleCrossRef" href="#t0020">Table 3</a> shows the treatment response at one month and at one year post-treatment in light of the different criteria commonly used to evaluate treatment response in CBP patients. For all criteria, a higher percentage of response was observed in the UDCA group compared to the OT group. Nevertheless, this difference was statistically significant only after one year of the treatment, according to Toronto and Rotterdam criteria.<elsevierMultimedia ident="t0020"></elsevierMultimedia>Survival probabilityDuring the follow-up period, 21 patients died from liver-related disease. In the UDCA group, three patients died, while in the OT group 18 died. The survival probability at one year was 0.97 (95% CI, 0.83-0.99) in the UDCA group and 0.83 (95% CI, 0.67-0.92) in the OT group; and the survival probabilities at 5 years were 0.89 (95% CI, 0.70-0.96) in the UDCA group and 0.49 (95% CI, (0.31-0.64) in the OT group, p < 0.001 (<a class="elsevierStyleCrossRef" href="#f0010">Figure 1</a>A).<elsevierMultimedia ident="f0010"></elsevierMultimedia>In univariate analysis, gender, total bilirubin (ULN), alanine aminotransferase (ULN), score Child-Pugh, his-tologic stage (IV vs. I to III), and Mayo Risk Score were factors related to risk of death (p < 0.20). In multivariate analyses, treatment, gender, and Mayo Risk Score were associated with risk of death; the HR of the group in the OT treatment vs. patients in the UDCA group was 8.78 (95% CI, 2.52-30.61), p = 0.001; patients that received OT died at a rate 8.78 times higher than those patients that received treatment with UDCA, where the Mayo Risk Score and the gender are held constants. In the same way, for each increase of one point in the Mayo Risk Score, the rate of death for liver disease was higher by 68% after adjustment by treatment group and by gender (<a class="elsevierStyleCrossRef" href="#t0025">Table 4</a>, <a class="elsevierStyleCrossRef" href="#f0010">Figure 1</a>B). <a class="elsevierStyleCrossRef" href="#f0010">Figure 1</a>B shows the difference in survival probabilities to females with 6.3 points in Mayor Risk Score treated with UDCA or OT.<elsevierMultimedia ident="t0025"></elsevierMultimedia>DiscussionResults suggest UDCA treatment as an optimum choice for patients with PBC not suitable for a liver transplant and considering the higher survival probability after five years with UDCA compared to those in the OT group (0.89 vs. 0.49).Results of this study confirm UDCA as proper treatment for patients with PBC in countries where liver transplants are still limited. Treatment response at one month and at one year of treatment was better in patients treated with UDCA.In Mexico, patients with histological diagnosis of PBC between 1972 and 1992 showed low probability of survival, 0.75, 0.44, and 0.13 at 1, 5, and 7 years.<a class="elsevierStyleCrossRef" href="#bib0075">14</a> These probabilities are lower than those reported in other countries.<a class="elsevierStyleCrossRefs" href="#bib0030">5,11,12,15-17</a>But survival probabilities at 5 years, 0.89, found in the present study in patients admitted at a third level referral hospital in Mexico City between 1992 and 2011 and treated with UDCA are similar to survival probabilities reported at 5 years by Zhang, et al., 0.8<a class="elsevierStyleCrossRefs" href="#bib0035">6,2</a>, ter Borg, et al., 0.87<a class="elsevierStyleCrossRef" href="#bib0095">18</a> and Kuiper, et al., 0.90,<a class="elsevierStyleCrossRef" href="#bib0065">12</a> in patients treated with UDCA. Differences in the grade of liver damage, treatment received, and number of patients included could explain differences in survival probabilities. In the studies of the Mexican population, patients treated before 1992 were treated with drugs other than UDCA.Treatment with 10-15 mg/kg/day UDCA vs. a placebo has been evaluated in various clinical essays,<a class="elsevierStyleCrossRefs" href="#bib0100">19-25</a> but not all studies report UDCA as beneficial for treating PBC.<a class="elsevierStyleCrossRefs" href="#bib0040">7,8</a> In the present study, results show a survival difference between the UDCA and OT group.Different prognostic factors with an impact on survival of PBC patients have been described: degree of hepatic damage at time of diagnostic; serum bilirubin higher than 1.57 mg/dL; serum albumin concentration lower than 3.8 mg/dL; and lack of response to UDCA treatment.<a class="elsevierStyleCrossRefs" href="#bib0080">15,16,26</a> In present study, UDCA treatment, gender, and Mayo Risk Score had impacts on the mortality of PBC patients. These findings are consistent with other reports.<a class="elsevierStyleCrossRefs" href="#bib0015">2,15,16</a>Before the UDCA era, the main reason for hepatic transplants in the United States was PBC. In the last few decades, the number of patients with PBC who require hepatic transplants has diminished by 20%.<a class="elsevierStyleCrossRef" href="#bib0140">27</a> According to U.S. statistics, PBC patients are now the sixth choice for suggested hepatic transplants.<a class="elsevierStyleCrossRef" href="#bib0145">28</a>The use of UDCA therapy to slow histological progression has a greater impact in Latin America because hepatic transplant program development there is very heterogeneous. Presently, hepatic transplants are only performed in 13 of the 19 countries of Latin America.<a class="elsevierStyleCrossRefs" href="#bib0150">29,30</a>In some countries, like Mexico, the programs are still being developed and it is exceptional to find a hepatic transplant program more than 10 years old that fulfills all necessary quality criteria. Therefore, it is hard to compare Latin American statistics to European or North American programs. It is necessary to continue to do research that will allow us to better typify PBC patients in Latin American countries and their response to UDCA treatment and to continue to assess the need, benefits, and risks of subjecting PBC patients to liver transplants.Limitations of our study are related to patient data collected retrospectively; however, selection and recall biases were minimized because information about diagnoses and drug treatment was taken from clinical records.The study suggests that the use of UDCA improves survival in patients with PBC in Mexico. Further randomized controlled studies should be conducted to evaluate the effect of UDCA therapy on the natural history, clinical manifestation, and prognosis of patients with PBC in Latin America.Abbreviations<ul class="elsevierStyleList" id="l0010"><li class="elsevierStyleListItem" id="u0010">•95% CI: 95% confidence interval.</li><li class="elsevierStyleListItem" id="u0015">•ALP: alkaline phosphatase.</li><li class="elsevierStyleListItem" id="u0020">•ALT: alanine aminotransferase.</li><li class="elsevierStyleListItem" id="u0025">•AMA: antimitochondrial antibody.</li><li class="elsevierStyleListItem" id="u0030">•AST: Aspartate aminotransferase.</li><li class="elsevierStyleListItem" id="u0035">•HR: hazard ratio.</li><li class="elsevierStyleListItem" id="u0040">•LLN: lower limit of normal.</li><li class="elsevierStyleListItem" id="u0045">•OLT: orthotopic liver transplantation.</li><li class="elsevierStyleListItem" id="u0050">•OT: other treatments.</li><li class="elsevierStyleListItem" id="u0055">•PBC: primary biliary cirrosis.</li><li class="elsevierStyleListItem" id="u0060">•UDCA: ursodeoxycholic acid.</li><li class="elsevierStyleListItem" id="u0065">•ULN: upper limit normal.</li></ul>Conflict of Interest StatementThe authors have no competing interests." "textoCompletoSecciones" => array:1 [ "secciones" => array:9 [ 0 => array:3 [ "identificador" => "xres1197541" "titulo" => "Abstract" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abs0010" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abs0015" "titulo" => "Material and Methods" ] 2 => array:2 [ "identificador" => "abs0020" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abs0025" "titulo" => "Conclusions" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1116227" "titulo" => "Keywords" ] 2 => array:2 [ "identificador" => "s0010" "titulo" => "Introduction" ] 3 => array:3 [ "identificador" => "s0015" "titulo" => "Material and Methods" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "s0020" "titulo" => "Patients" ] 1 => array:2 [ "identificador" => "s0025" "titulo" => "Ethical aspects" ] 2 => array:2 [ "identificador" => "s0030" "titulo" => "Statistical analyses" ] ] ] 4 => array:3 [ "identificador" => "s0035" "titulo" => "Results" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "s0040" "titulo" => "Baseline characteristics" ] 1 => array:2 [ "identificador" => "s0045" "titulo" => "Treatment response" ] 2 => array:2 [ "identificador" => "s0050" "titulo" => "Survival probability" ] ] ] 5 => array:2 [ "identificador" => "s0055" "titulo" => "Discussion" ] 6 => array:2 [ "identificador" => "s0060" "titulo" => "Abbreviations" ] 7 => array:2 [ "identificador" => "s0065" "titulo" => "Conflict of Interest Statement" ] 8 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2016-07-03" "fechaAceptado" => "2016-09-08" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1116227" "palabras" => array:4 [ 0 => "Ursodeoxycholic acid" 1 => "Primary biliary cholangitis" 2 => "Latin America" 3 => "Survival rates" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:3 [ "titulo" => "Abstract" "resumen" => "IntroductionThere is little information on survival rates of patients with primary biliary cholangtis (PBC) in developing countries. This is particularly true in Latin America, where the number of liver transplants performed remains extremely low for patients with advanced liver disease who fulfill criteria for liver transplantation. The goal of this study was to compare survival rate of patients with PBC in developing countries who were treated with ursodeoxycholic acid (UDCA) versus survival of patients who received other treatments (OT) without UDCA, prescribed before the UDCA era. Material and MethodsA retrospective study was performed, including records of 78 patients with PBC in the liver unit in a third level referral hospital in Mexico City. Patients were followed for five years from initial diagnosis until death related to liver disease or to the end of the study. Patients received UDCA (15 mg/kg/per day) (n = 41) or OT (n = 37) before introduction of UDCA in Mexico. ResultsResponse to treatment was higher in the group that received UDCA. In the five years of follow-up, survival rates were significantly higher in the UDCA group than in the OT group. The hazard ratio of death was higher in the OT group vs. UDCA group, HR 8.78 (95% CI, 2.52-30.61); Mayo Risk Score and gender were independently associated with the risk of death. ConclusionsThe study confirms that the use of UDCA in countries with a limited liver transplant program increases survival in comparison to other treatments used before the introduction of UDCA." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abs0010" "titulo" => "Introduction" ] 1 => array:2 [ "identificador" => "abs0015" "titulo" => "Material and Methods" ] 2 => array:2 [ "identificador" => "abs0020" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abs0025" "titulo" => "Conclusions" ] ] ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "f0010" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 835 "Ancho" => 2075 "Tamanyo" => 133046 ] ] "descripcion" => array:1 [ "en" => "A. Survival probabilities estimates by Kaplan-Meier method, in five years of follow-up of CBP patients treated with UDCA and others drugs vs. OT without UDCA. B. Adjusted survival curves obtained from a Cox Proportional Hazard Model by treatment (OT vs. UDCA) and letting Mayo Score Risk be the mean value (6.3) and female gender." ] ] 1 => array:7 [ "identificador" => "t0010" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "Data are expressed as means ± standard deviation. ALP: alkaline phosphate. ULN: Upper limit of normal. AST: aspartate aminotransferase. ALT: alanine aminotransferase. LLN: lower limit of normal. UDCA: ursodeoxy-cholic acid and other drugs. OT: other drugs." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Characteristic \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">UDCA Group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OT Group \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">(n = 41) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">(n = 37) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">46.2 ± 9.81 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">45.6 ± 12.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female gender, n(%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">38 (92.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35 (94.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ALP( ULN) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.2 ± 3.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.0 ± 4.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Albumin (LLN) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0 ± 0.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0 ± 0.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bilirrubin (ULN) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.0 ± 3.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.0 ± 5.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AST (ULN) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.2 ± 1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.2 ± 2.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ALT (ULN) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.1 ± 2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.1 ± 2.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Creatinine (mg/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.7 ± 0.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.6 ± 0.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Child-Pugh index \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.3 ± 1.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.8 ± 1.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">A \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 (48.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (46.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">B \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 (39.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">17 (46.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (12.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (8.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mayo Risk Score \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.9 ± 1.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6.8 ± 1.9 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ludwing Histological stage \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">I \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">16 (39.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (37.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">I \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">11 (26.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 (21.6) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (22.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (13.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (12.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 (27.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2045065.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Baseline characteristics of the patients in this study." ] ] 2 => array:7 [ "identificador" => "t0015" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "Data are expressed as means ± standard deviation. ALP: alkaline phosphate Upper limit of normal (ULN) = 120 U/L, albumin lower limit of normal (LLN) = 3.5 g/dL, aspartate aminotransferase (AST) (ULN = 35 U/L), alanine aminotransferase (ALT) (ULN = 35 U/L), bilirubin (ULN = 1.0 mg/dL). a Paired t test. b Student t test, p < 0.05." "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">UDCA Group (n = 41)</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OT Group (n = 37)</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Baseline \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">One month \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Value pa \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Baseline \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">One month \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Value pa \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">post-treatment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">post-treatment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ALP (ULN) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.1 ± 3.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.7 ± 2.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.005 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.9 ± 4.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.4 ± 2.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.330 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Albumin (LLN) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0 ± 0.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0 ± 0.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.997 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0 ± 0.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.0 ± 0.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.479 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bilirubin (ULN) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.0 ± 3.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.1 ± 2.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.014 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4.8 ± 5.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.7 ± 6.0b \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.276 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">AST (ULN) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.2 ± 1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.4 ± 1.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.004 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.4 ± 1.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.8 ± 1.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.229 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">ALT (ULN) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.1 ± 2.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.3 ± 1.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.011 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.1 ± 3.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.5 ± 1.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.299 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2045066.png" ] ] ] ] "descripcion" => array:1 [ "en" => "Biochemical indicators of hepatic function before and after one month of treatment." ] ] 3 => array:7 [ "identificador" => "t0020" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Criteria \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">At 1 month n (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">At 1 year n (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">UDCA group \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OT group \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">p value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">UDCA group \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">OT group \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">p value \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Paris<a class="elsevierStyleCrossRef" href="#tbl3fn1">a</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Barcelona<a class="elsevierStyleCrossRef" href="#tbl3fn2">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10 (25.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5 (13.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.204 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">14 (35.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (21.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.202 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Toronto<a class="elsevierStyleCrossRef" href="#tbl3fn3">c</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 (47.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">9 (29.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.114 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">19 (47.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (23.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.046 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Rotterdam<a class="elsevierStyleCrossRef" href="#tbl3fn4">d</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15 (37.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (20.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.097 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">20 (51.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">7 (21.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.009 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2045068.png" ] ] ] "notaPie" => array:4 [ 0 => array:3 [ "identificador" => "tbl3fn1" "etiqueta" => "a" "nota" => "ALP ≤ 3ULN and AST ≤ 2 ULN and normal total bilirubin." ] 1 => array:3 [ "identificador" => "tbl3fn2" "etiqueta" => "b" "nota" => "ALP minor to 40% of baseline ALP." ] 2 => array:3 [ "identificador" => "tbl3fn3" "etiqueta" => "c" "nota" => "ALT < 1.76 ULN." ] 3 => array:3 [ "identificador" => "tbl3fn4" "etiqueta" => "d" "nota" => "Normal total bilirubin or normal albumin if the two had abnormal value at baseline or normal total bilirubin and normal albumin if only one of two was abnormal at baseline." ] ] ] "descripcion" => array:1 [ "en" => "Treatment response according to different criteria." ] ] 4 => array:7 [ "identificador" => "t0025" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variable \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Hazard Ratio<a class="elsevierStyleCrossRef" href="#tbl4fn1">a</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">95% CI \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Other treatment vs. UDCA treatment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8.78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.52-30.61 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Baseline Mayo Risk Score<a class="elsevierStyleCrossRef" href="#tbl4fn2">b</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.26-2.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.000 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2045067.png" ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tbl4fn1" "etiqueta" => "a" "nota" => "Hazard Ratio, adjusted by gender." ] 1 => array:3 [ "identificador" => "tbl4fn2" "etiqueta" => "b" "nota" => "Letting Mayo Score Risk be centred at the mean value (6.3)." ] ] ] "descripcion" => array:1 [ "en" => "Risks factors associated with mortality at five years of follow-up in patients with PBC. Multivariate analyses, Cox, proportional hazard model." ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bs0010" "bibliografiaReferencia" => array:30 [ 0 => array:3 [ "identificador" => "bib0010" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary biliary cirrhosis: therapeutic advances" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Czul F." 1 => "Peyton A." 2 => "Levy C." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.cld.2012.12.003" "Revista" => array:6 [ "tituloSerie" => "Clin Liver Dis" "fecha" => "2013" "volumen" => "17" "paginaInicial" => "229" "paginaFinal" => "242" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23540499" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0015" "etiqueta" => "2." 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Yazmín Karel Melchor-Mendoza*,**,***, Braulio Martínez-Benítez

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brauliomb77@yahoo.com.mx

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, Aline Mina-Hawat**, Gustavo Rodríguez-Leal**, Ximena Duque**, Segundo Moran-Villota***

* Social Service and Department of Pathology, National Institute of Medical Sciences and Nutrition “Salvador Zubirán”, Mexico City

** Laboratory of Gastro-Hepatology Research, Hospital of Pediatrics, National Medical Center XXI Century, Mexican Institute of Social Security, Mexico

*** Medica Sur Clinic Foundation, Mexico

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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="s0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0040">Introduction</span><p id="p0010" class="elsevierStylePara elsevierViewall">Primary biliary cholangitis &#40;PBC&#41; is an autoimmune liver disease characterized by progressive destruction of intrahepatic bile ducts&#44; which may lead to biliary cirrhosis&#44; portal inflammation&#44; and liver failure&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">1&#44;2</span></a> Ursodeoxycholic acid &#40;UDCA&#41; is the only drug approved by the U&#46;S&#46; Food and Drug Administration to treat PBC&#44; with a recommended dosage of 13-15 mg&#47;kg&#47;day&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">1-3</span></a> The use of obeti-cholic acid is on the horizon&#46;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">4</span></a></p><p id="p0015" class="elsevierStylePara elsevierViewall">It has been suggested that UDCA treatment improved the serum liver test results&#44; slowed the histological progress&#44; and improved patients&#8217; survival without an orthotropic liver transplant&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">5&#44;6</span></a> However&#44; the effect of UDCA on survival is still controversial&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">7&#44;8</span></a></p><p id="p0020" class="elsevierStylePara elsevierViewall">At present&#44; studies on PBC have mostly been carried out in Asia&#44; Europe&#44; Australia&#44; and North America&#44; in developed countries with liver transplant programs for PBC&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">2&#44;5-8</span></a> However&#44; there is little information about PBC in Latin America&#46; Currently&#44; there are no studies in Mexico or other countries in Latin America that evaluate the medium-term effect of UDCA treatment on survival of patients with PBC&#46;</p><p id="p0025" class="elsevierStylePara elsevierViewall">The aim of this study was to compare survival rates of patients in developing countries with PBC using UDCA versus survival rates of patients who received other drugs &#40;OT&#41; prescribed before the UDCA era&#46;</p></span><span id="s0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0045">Material and Methods</span><span id="s0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0050">Patients</span><p id="p0030" class="elsevierStylePara elsevierViewall">A retrospective study was performed in the Department of Pathology of the National Institute of Medical Sciences and Nutrition Salvador Zubiran in Mexico City&#44; included patients diagnosed with PBC between 1971 and 2011&#46; All patients who were included had histological and biochemical evidence of cholestasis based mainly on nonsuppurative destructive cholangitis and destruction of interlobular bile ducts&#44; alkaline phosphatase &#40;ALP&#41; elevation at least 1&#46;5 times the upper limit normal &#40;ULN&#41;&#44; and presence of positive antimitochondrial antibody &#40;AMA&#41;&#46; Exclusion criteria were features suggestive of other coexistent liver diseases&#44; including overlap syndrome&#44; alcoholic liver disease&#44; a positive serological test for hepatitis B or C&#44; non-alcoholic stea-tohepatitis&#44; and hepatocellular carcinoma&#46; The histological stage was assessed using Ludwig criteria&#58; portal hepatitis&#44; bile duct abnormalities&#44; or both are present &#40;stage 1&#41;&#44; Peri-portal fibrosis is present&#44; with or without periportal inflammation &#40;stage 2&#41;&#44; bridging fibrosis or necrosis or both &#40;stage 3&#41;&#44; and cirrhosis &#40;stage 4&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">9</span></a></p><p id="p0035" class="elsevierStylePara elsevierViewall">The following parameters were obtained from medical records&#58; age&#44; gender&#44; associated diseases&#44; symptoms&#44; and liver function test &#91;serum bilirubin levels&#44; albumin&#44; pro-thrombin time&#44; alkaline phospatase &#40;ALP&#41;&#44; alanine ami-notransferase &#40;ALT&#41;&#44; aspartate aminotransferase &#40;AST&#41;&#93;&#46; Results of liver function tests were recorded at baseline&#44; one month and one year after starting the treatment&#46; The cut-off points used were&#58; ALP 120 U&#47;L as the upper limit of normal &#40;ULN&#41;&#44; 35 U&#47;L for AST and ALT&#44; and 1&#46;0 mg&#47; dL for bilirubin&#46; The lower limit of normal &#40;LLN&#41; for albumin was 3&#46;5 g&#47;dL&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">10</span></a> Patients had received UDCA &#40;15 mg&#47;kg&#47;per day&#41; since 1992 and before other drugs &#40;OT&#41; as colchicine &#40;n &#61; 28&#41;&#44; cholestyramine &#40;n &#61; 18&#41;&#44; penicilla-mine &#40;n &#61; 7&#41;&#44; azathioprine &#40;n &#61; 5&#41;&#44; or prednisolone &#40;n &#61; 13&#41;&#44; at standard doses&#46; In some cases&#44; patients received more than one drug&#46;</p></span><span id="s0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0055">Ethical aspects</span><p id="p0040" class="elsevierStylePara elsevierViewall">This study was approved by the Ethics Board of the National Institute of Medical Sciences and Nutrition Salvador Zubiran&#44; Mexico City&#44; Mexico&#46; The study protocol conforms to the ethical guidelines of the 1975 Declaration of Helsinki as reflected in <span class="elsevierStyleItalic">a priori</span> approval by the institution&#39;s human research committee&#46;</p></span><span id="s0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0060">Statistical analyses</span><p id="p0045" class="elsevierStylePara elsevierViewall">In descriptive analyses&#44; data are expressed as means &#177; standard deviation&#44; and percentages&#46; Categorical variables were compared by &#37;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">2</span></a> test among both groups and continuous variables by Student t-test&#46; A paired t test was used to compare means before and after one month of treatment&#46; The biochemical response to UDCA or OT was evaluated by comparing proportion of treatment response at one month and at one year after treatment&#44; according to Barcelona criteria &#40;decrease in ALP &#62; 40&#37; of the baseline level or normal level&#41;&#44; Paris criteria &#40;ALP level <span class="elsevierStyleBold">&#60;</span> 3 ULN&#44; together with AST level <span class="elsevierStyleBold">&#60;</span> 2 ULN and a normal bilirubin level&#41;&#44; Rotterdam criteria &#40;normal bilirubin and albumin concentrations when one or both parameters were abnormal before treatment&#44; or normal bilirubin or albumin concentrations after treatment when both were abnormal at entry&#41;&#44; and Toronto criteria &#40;ALP level &#60; 1&#46;76 ULN&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">2</span></a>&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">11</span></a></p><p id="p0050" class="elsevierStylePara elsevierViewall">Survival analysis was used&#58; The follow-up started from the date at histological diagnosis of PBC&#44; time zero &#40;t0&#41;&#44; and the end point was liver-related death&#46; Time at event was calculated&#46; Patients who did not present the event was censored at the end of the study&#44; also was censored patients who died from causes unrelated to liver failure and patients that were lost at follow-up&#59; also were censored patients referred for liver transplantation at the moment of OLT&#46; Liver-related death was defined as death due to liver failure or death occurring within two months of an episode of variceal bleeding&#44; spontaneous bacterial peritonitis&#44; hepatorenal syndrome&#44; or hepatic encephalopathy&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">12</span></a></p><p id="p0055" class="elsevierStylePara elsevierViewall">Probabilities of survival were estimated by the Kaplan-Meier method&#46; For the univariate analyses&#44; we compared the survival functions of categorical variables using the log-rank test&#46; To compare survival by continuous variables&#44; Cox proportional hazard regression model with one only variable was used&#46;</p><p id="p0060" class="elsevierStylePara elsevierViewall">Multivariate analysis to evaluate the associations between treatments received and the survival function of patients with CBP was done using Cox proportional-hazard risk regression models&#46; Variables with p value less than 0&#46;20 at univariate analysis were included in the multivaria-ble analyses&#59; and in the final model&#44; variables statistically associated with the risk of death or important confounder variables were included&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">13</span></a> Model assumptions and good fit were tested&#46; The analysis was performed using the statistical software STATA &#40;version 12&#46;0&#44; STATA Corporation&#44; College Station&#44; TX&#44; USA&#41;&#46;</p></span></span><span id="s0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0065">Results</span><span id="s0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0070">Baseline characteristics</span><p id="p0065" class="elsevierStylePara elsevierViewall">A total of 78 patients matched by age and sex were included&#58; 41 in the UDCA Group and 37 in the OT Group&#46; When comparing the baseline characteristics of the treatment groups &#40;<a class="elsevierStyleCrossRef" href="#t0010">Table 1</a>&#41;&#44; a higher concentration of bilirubin and higher Mayo Risk Score were found in the OT group and respect liver damage&#44; in UDCA group fibrosis &#40;n &#61; 20&#47;41&#41; and cirrhosis &#40;n &#61; 5&#47;41&#41; &#59; and in OT group fibrosis &#40;n &#61; 13&#47;38&#41; and cirrhosis &#40;n &#61; 10&#47;38&#41; was found&#46;</p><elsevierMultimedia ident="t0010"></elsevierMultimedia></span><span id="s0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0075">Treatment response</span><p id="p0070" class="elsevierStylePara elsevierViewall">After one month of treatment&#44; an intragroup comparison of UDCA group showed a significant reduction in ALP&#44; total bilirubin&#44; AST&#44; and ALT concentration&#59; no difference with statistical significance was observed in the OT group &#40;<a class="elsevierStyleCrossRef" href="#t0015">Table 2</a>&#41;&#46; Furthermore&#44; when comparisons after one month post-treatment between groups were done&#44; total bilirubin &#40;ULN&#41; was statistically different&#59; it was higher in the OT group &#40;2&#46;1 &#177; 2&#46;3 <span class="elsevierStyleItalic">vs&#46;</span> 5&#46;7 &#177; 6&#46;0&#44; p &#61; 0&#46;007&#41;&#46;</p><elsevierMultimedia ident="t0015"></elsevierMultimedia><p id="p0075" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#t0020">Table 3</a> shows the treatment response at one month and at one year post-treatment in light of the different criteria commonly used to evaluate treatment response in CBP patients&#46; For all criteria&#44; a higher percentage of response was observed in the UDCA group compared to the OT group&#46; Nevertheless&#44; this difference was statistically significant only after one year of the treatment&#44; according to Toronto and Rotterdam criteria&#46;</p><elsevierMultimedia ident="t0020"></elsevierMultimedia></span><span id="s0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0080">Survival probability</span><p id="p0080" class="elsevierStylePara elsevierViewall">During the follow-up period&#44; 21 patients died from liver-related disease&#46; In the UDCA group&#44; three patients died&#44; while in the OT group 18 died&#46; The survival probability at one year was 0&#46;97 &#40;95&#37; CI&#44; 0&#46;83-0&#46;99&#41; in the UDCA group and 0&#46;83 &#40;95&#37; CI&#44; 0&#46;67-0&#46;92&#41; in the OT group&#59; and the survival probabilities at 5 years were 0&#46;89 &#40;95&#37; CI&#44; 0&#46;70-0&#46;96&#41; in the UDCA group and 0&#46;49 &#40;95&#37; CI&#44; &#40;0&#46;31-0&#46;64&#41; in the OT group&#44; p &#60; 0&#46;001 &#40;<a class="elsevierStyleCrossRef" href="#f0010">Figure 1</a>A&#41;&#46;</p><elsevierMultimedia ident="f0010"></elsevierMultimedia><p id="p0085" class="elsevierStylePara elsevierViewall">In univariate analysis&#44; gender&#44; total bilirubin &#40;ULN&#41;&#44; alanine aminotransferase &#40;ULN&#41;&#44; score Child-Pugh&#44; his-tologic stage &#40;IV <span class="elsevierStyleItalic">vs&#46;</span> I to III&#41;&#44; and Mayo Risk Score were factors related to risk of death &#40;p &#60; 0&#46;20&#41;&#46; In multivariate analyses&#44; treatment&#44; gender&#44; and Mayo Risk Score were associated with risk of death&#59; the HR of the group in the OT treatment <span class="elsevierStyleItalic">vs&#46;</span> patients in the UDCA group was 8&#46;78 &#40;95&#37; CI&#44; 2&#46;52-30&#46;61&#41;&#44; p &#61; 0&#46;001&#59; patients that received OT died at a rate 8&#46;78 times higher than those patients that received treatment with UDCA&#44; where the Mayo Risk Score and the gender are held constants&#46; In the same way&#44; for each increase of one point in the Mayo Risk Score&#44; the rate of death for liver disease was higher by 68&#37; after adjustment by treatment group and by gender &#40;<a class="elsevierStyleCrossRef" href="#t0025">Table 4</a>&#44; <a class="elsevierStyleCrossRef" href="#f0010">Figure 1</a>B&#41;&#46; <a class="elsevierStyleCrossRef" href="#f0010">Figure 1</a>B shows the difference in survival probabilities to females with 6&#46;3 points in Mayor Risk Score treated with UDCA or OT&#46;</p><elsevierMultimedia ident="t0025"></elsevierMultimedia></span></span><span id="s0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0085">Discussion</span><p id="p0090" class="elsevierStylePara elsevierViewall">Results suggest UDCA treatment as an optimum choice for patients with PBC not suitable for a liver transplant and considering the higher survival probability after five years with UDCA compared to those in the OT group &#40;0&#46;89 <span class="elsevierStyleItalic">vs&#46;</span> 0&#46;49&#41;&#46;</p><p id="p0095" class="elsevierStylePara elsevierViewall">Results of this study confirm UDCA as proper treatment for patients with PBC in countries where liver transplants are still limited&#46; Treatment response at one month and at one year of treatment was better in patients treated with UDCA&#46;</p><p id="p0100" class="elsevierStylePara elsevierViewall">In Mexico&#44; patients with histological diagnosis of PBC between 1972 and 1992 showed low probability of survival&#44; 0&#46;75&#44; 0&#46;44&#44; and 0&#46;13 at 1&#44; 5&#44; and 7 years&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">14</span></a> These probabilities are lower than those reported in other countries&#46;<a class="elsevierStyleCrossRefs" href="#bib0030"><span class="elsevierStyleSup">5&#44;11&#44;12&#44;15-17</span></a></p><p id="p0105" class="elsevierStylePara elsevierViewall">But survival probabilities at 5 years&#44; 0&#46;89&#44; found in the present study in patients admitted at a third level referral hospital in Mexico City between 1992 and 2011 and treated with UDCA are similar to survival probabilities reported at 5 years by Zhang&#44; <span class="elsevierStyleItalic">et al&#46;&#44;</span> 0&#46;8<a class="elsevierStyleCrossRefs" href="#bib0035"><span class="elsevierStyleSup">6&#44;2</span></a>&#44; ter Borg&#44; <span class="elsevierStyleItalic">et al&#46;&#44;</span> 0&#46;87<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">18</span></a> and Kuiper&#44; <span class="elsevierStyleItalic">et al&#46;&#44;</span> 0&#46;90&#44;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">12</span></a> in patients treated with UDCA&#46; Differences in the grade of liver damage&#44; treatment received&#44; and number of patients included could explain differences in survival probabilities&#46; In the studies of the Mexican population&#44; patients treated before 1992 were treated with drugs other than UDCA&#46;</p><p id="p0110" class="elsevierStylePara elsevierViewall">Treatment with 10-15 mg&#47;kg&#47;day UDCA <span class="elsevierStyleItalic">vs&#46;</span> a placebo has been evaluated in various clinical essays&#44;<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">19-25</span></a> but not all studies report UDCA as beneficial for treating PBC&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">7&#44;8</span></a> In the present study&#44; results show a survival difference between the UDCA and OT group&#46;</p><p id="p0115" class="elsevierStylePara elsevierViewall">Different prognostic factors with an impact on survival of PBC patients have been described&#58; degree of hepatic damage at time of diagnostic&#59; serum bilirubin higher than 1&#46;57 mg&#47;dL&#59; serum albumin concentration lower than 3&#46;8 mg&#47;dL&#59; and lack of response to UDCA treatment&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">15&#44;16&#44;26</span></a> In present study&#44; UDCA treatment&#44; gender&#44; and Mayo Risk Score had impacts on the mortality of PBC patients&#46; These findings are consistent with other reports&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">2&#44;15&#44;16</span></a></p><p id="p0120" class="elsevierStylePara elsevierViewall">Before the UDCA era&#44; the main reason for hepatic transplants in the United States was PBC&#46; In the last few decades&#44; the number of patients with PBC who require hepatic transplants has diminished by 20&#37;&#46;<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">27</span></a> According to U&#46;S&#46; statistics&#44; PBC patients are now the sixth choice for suggested hepatic transplants&#46;<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">28</span></a></p><p id="p0125" class="elsevierStylePara elsevierViewall">The use of UDCA therapy to slow histological progression has a greater impact in Latin America because hepatic transplant program development there is very heterogeneous&#46; Presently&#44; hepatic transplants are only performed in 13 of the 19 countries of Latin America&#46;<a class="elsevierStyleCrossRefs" href="#bib0150"><span class="elsevierStyleSup">29&#44;30</span></a></p><p id="p0130" class="elsevierStylePara elsevierViewall">In some countries&#44; like Mexico&#44; the programs are still being developed and it is exceptional to find a hepatic transplant program more than 10 years old that fulfills all necessary quality criteria&#46; Therefore&#44; it is hard to compare Latin American statistics to European or North American programs&#46; It is necessary to continue to do research that will allow us to better typify PBC patients in Latin American countries and their response to UDCA treatment and to continue to assess the need&#44; benefits&#44; and risks of subjecting PBC patients to liver transplants&#46;</p><p id="p0135" class="elsevierStylePara elsevierViewall">Limitations of our study are related to patient data collected retrospectively&#59; however&#44; selection and recall biases were minimized because information about diagnoses and drug treatment was taken from clinical records&#46;</p><p id="p0140" class="elsevierStylePara elsevierViewall">The study suggests that the use of UDCA improves survival in patients with PBC in Mexico&#46; Further randomized controlled studies should be conducted to evaluate the effect of UDCA therapy on the natural history&#44; clinical manifestation&#44; and prognosis of patients with PBC in Latin America&#46;</p></span><span id="s0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0090">Abbreviations</span><p id="p0145" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="l0010"><li class="elsevierStyleListItem" id="u0010"><span class="elsevierStyleLabel">&#8226;</span><p id="p0150" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">95&#37; CI&#58;</span> 95&#37; confidence interval&#46;</p></li><li class="elsevierStyleListItem" id="u0015"><span class="elsevierStyleLabel">&#8226;</span><p id="p0155" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">ALP&#58;</span> alkaline phosphatase&#46;</p></li><li class="elsevierStyleListItem" id="u0020"><span class="elsevierStyleLabel">&#8226;</span><p id="p0160" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">ALT&#58;</span> alanine aminotransferase&#46;</p></li><li class="elsevierStyleListItem" id="u0025"><span class="elsevierStyleLabel">&#8226;</span><p id="p0165" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">AMA&#58;</span> antimitochondrial antibody&#46;</p></li><li class="elsevierStyleListItem" id="u0030"><span class="elsevierStyleLabel">&#8226;</span><p id="p0170" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">AST&#58;</span> Aspartate aminotransferase&#46;</p></li><li class="elsevierStyleListItem" id="u0035"><span class="elsevierStyleLabel">&#8226;</span><p id="p0175" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">HR&#58;</span> hazard ratio&#46;</p></li><li class="elsevierStyleListItem" id="u0040"><span class="elsevierStyleLabel">&#8226;</span><p id="p0180" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">LLN&#58;</span> lower limit of normal&#46;</p></li><li class="elsevierStyleListItem" id="u0045"><span class="elsevierStyleLabel">&#8226;</span><p id="p0185" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">OLT&#58;</span> orthotopic liver transplantation&#46;</p></li><li class="elsevierStyleListItem" id="u0050"><span class="elsevierStyleLabel">&#8226;</span><p id="p0190" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">OT&#58;</span> other treatments&#46;</p></li><li class="elsevierStyleListItem" id="u0055"><span class="elsevierStyleLabel">&#8226;</span><p id="p0195" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">PBC&#58;</span> primary biliary cirrosis&#46;</p></li><li class="elsevierStyleListItem" id="u0060"><span class="elsevierStyleLabel">&#8226;</span><p id="p0200" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">UDCA&#58;</span> ursodeoxycholic acid&#46;</p></li><li class="elsevierStyleListItem" id="u0065"><span class="elsevierStyleLabel">&#8226;</span><p id="p0205" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleBold">ULN&#58;</span> upper limit normal&#46;</p></li></ul></p></span><span id="s0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0095">Conflict of Interest Statement</span><p id="p0210" class="elsevierStylePara elsevierViewall">The authors have no competing interests&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
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          "identificador" => "xres1197541"
          "titulo" => "Abstract"
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              "titulo" => "Introduction"
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              "titulo" => "Results"
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        1 => array:2 [
          "identificador" => "xpalclavsec1116227"
          "titulo" => "Keywords"
        ]
        2 => array:2 [
          "identificador" => "s0010"
          "titulo" => "Introduction"
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        3 => array:3 [
          "identificador" => "s0015"
          "titulo" => "Material and Methods"
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            0 => array:2 [
              "identificador" => "s0020"
              "titulo" => "Patients"
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            1 => array:2 [
              "identificador" => "s0025"
              "titulo" => "Ethical aspects"
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            2 => array:2 [
              "identificador" => "s0030"
              "titulo" => "Statistical analyses"
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        ]
        4 => array:3 [
          "identificador" => "s0035"
          "titulo" => "Results"
          "secciones" => array:3 [
            0 => array:2 [
              "identificador" => "s0040"
              "titulo" => "Baseline characteristics"
            ]
            1 => array:2 [
              "identificador" => "s0045"
              "titulo" => "Treatment response"
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            2 => array:2 [
              "identificador" => "s0050"
              "titulo" => "Survival probability"
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        ]
        5 => array:2 [
          "identificador" => "s0055"
          "titulo" => "Discussion"
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        6 => array:2 [
          "identificador" => "s0060"
          "titulo" => "Abbreviations"
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        7 => array:2 [
          "identificador" => "s0065"
          "titulo" => "Conflict of Interest Statement"
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        8 => array:1 [
          "titulo" => "References"
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    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2016-07-03"
    "fechaAceptado" => "2016-09-08"
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      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Keywords"
          "identificador" => "xpalclavsec1116227"
          "palabras" => array:4 [
            0 => "Ursodeoxycholic acid"
            1 => "Primary biliary cholangitis"
            2 => "Latin America"
            3 => "Survival rates"
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    "resumen" => array:1 [
      "en" => array:3 [
        "titulo" => "Abstract"
        "resumen" => "<span id="abs0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0015"><span class="elsevierStyleBold">Introduction</span></span><p id="sp0045" class="elsevierStyleSimplePara elsevierViewall">There is little information on survival rates of patients with primary biliary cholangtis &#40;PBC&#41; in developing countries&#46; This is particularly true in Latin America&#44; where the number of liver transplants performed remains extremely low for patients with advanced liver disease who fulfill criteria for liver transplantation&#46; The goal of this study was to compare survival rate of patients with PBC in developing countries who were treated with ursodeoxycholic acid &#40;UDCA&#41; versus survival of patients who received other treatments &#40;OT&#41; without UDCA&#44; prescribed before the UDCA era&#46;</p></span> <span id="abs0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0020"><span class="elsevierStyleBold">Material and Methods</span></span><p id="sp0050" class="elsevierStyleSimplePara elsevierViewall">A retrospective study was performed&#44; including records of 78 patients with PBC in the liver unit in a third level referral hospital in Mexico City&#46; Patients were followed for five years from initial diagnosis until death related to liver disease or to the end of the study&#46; Patients received UDCA &#40;15 mg&#47;kg&#47;per day&#41; &#40;n &#61; 41&#41; or OT &#40;n &#61; 37&#41; before introduction of UDCA in Mexico&#46;</p></span> <span id="abs0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0025"><span class="elsevierStyleBold">Results</span></span><p id="sp0055" class="elsevierStyleSimplePara elsevierViewall">Response to treatment was higher in the group that received UDCA&#46; In the five years of follow-up&#44; survival rates were significantly higher in the UDCA group than in the OT group&#46; The hazard ratio of death was higher in the OT group vs&#46; UDCA group&#44; HR 8&#46;78 &#40;95&#37; CI&#44; 2&#46;52-30&#46;61&#41;&#59; Mayo Risk Score and gender were independently associated with the risk of death&#46;</p></span> <span id="abs0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="st0030"><span class="elsevierStyleBold">Conclusions</span></span><p id="sp0060" class="elsevierStyleSimplePara elsevierViewall">The study confirms that the use of UDCA in countries with a limited liver transplant program increases survival in comparison to other treatments used before the introduction of UDCA&#46;</p></span>"
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            "titulo" => "Introduction"
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            "titulo" => "Material and Methods"
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            "identificador" => "abs0020"
            "titulo" => "Results"
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        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
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        "descripcion" => array:1 [
          "en" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">A&#46;</span> Survival probabilities estimates by Kaplan-Meier method&#44; in five years of follow-up of CBP patients treated with UDCA and others drugs vs&#46; OT without UDCA&#46; <span class="elsevierStyleBold">B&#46;</span> Adjusted survival curves obtained from a Cox Proportional Hazard Model by treatment &#40;OT vs&#46; UDCA&#41; and letting Mayo Score Risk be the mean value &#40;6&#46;3&#41; and female gender&#46;</p>"
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          "leyenda" => "<p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Data are expressed as means &#177; standard deviation&#46; ALP&#58; alkaline phosphate&#46; ULN&#58; Upper limit of normal&#46; AST&#58; aspartate aminotransferase&#46; ALT&#58; alanine aminotransferase&#46; LLN&#58; lower limit of normal&#46; UDCA&#58; ursodeoxy-cholic acid and other drugs&#46; OT&#58; other drugs&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Characteristic&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">UDCA Group&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">OT Group&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#40;n &#61; 41&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&#40;n &#61; 37&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">46&#46;2 &#177; 9&#46;81&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">45&#46;6 &#177; 12&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Female gender&#44; n&#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">38 &#40;92&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35 &#40;94&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ALP&#40; ULN&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;2 &#177; 3&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">4&#46;0 &#177; 4&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Albumin &#40;LLN&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0 &#177; 0&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0 &#177; 0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bilirrubin &#40;ULN&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;0 &#177; 3&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;0 &#177; 5&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AST &#40;ULN&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;2 &#177; 1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;2 &#177; 2&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ALT &#40;ULN&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;1 &#177; 2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;1 &#177; 2&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Creatinine &#40;mg&#47;dL&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;7 &#177; 0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;6 &#177; 0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Child-Pugh index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;3 &#177; 1&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;8 &#177; 1&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">A&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;48&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;46&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">B&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">16 &#40;39&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">17 &#40;46&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;12&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;8&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Mayo Risk Score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5&#46;9 &#177; 1&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">6&#46;8 &#177; 1&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ludwing Histological stage&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">I&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16 &#40;39&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">14 &#40;37&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleBold">I</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">11 &#40;26&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">8 &#40;21&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;22&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;13&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">IV&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;12&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;27&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t  " colspan="3" align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">UDCA Group &#40;n &#61; 41&#41;</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="3" align="left" valign="\n
                  \t\t\t\t\ttop\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Baseline&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttop\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Baseline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">One month&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Value p<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">post-treatment&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">post-treatment&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">ALP &#40;ULN&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">5&#46;1 &#177; 3&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">3&#46;7 &#177; 2&#46;4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;005&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;9 &#177; 4&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">3&#46;4 &#177; 2&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;330&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Albumin &#40;LLN&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0 &#177; 0&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">1&#46;0 &#177; 0&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;997&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0 &#177; 0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;0 &#177; 0&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;479&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bilirubin &#40;ULN&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;0 &#177; 3&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">2&#46;1 &#177; 2&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;014&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;276&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">AST &#40;ULN&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;2 &#177; 1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;4 &#177; 1&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;4 &#177; 1&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;8 &#177; 1&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;229&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">ALT &#40;ULN&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;1 &#177; 2&#46;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;3 &#177; 1&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;1 &#177; 3&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;5 &#177; 1&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;299&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Criteria&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">At 1 month n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">At 1 year n &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">UDCA group&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">UDCA group&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">OT group&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">p value&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t">Paris<a class="elsevierStyleCrossRef" href="#tbl3fn1"><span class="elsevierStyleSup">a</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Barcelona<a class="elsevierStyleCrossRef" href="#tbl3fn2"><span class="elsevierStyleSup">b</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10 &#40;25&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">5 &#40;13&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;204&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">14 &#40;35&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;21&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;202&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Toronto<a class="elsevierStyleCrossRef" href="#tbl3fn3"><span class="elsevierStyleSup">c</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;47&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">9 &#40;29&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;114&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">19 &#40;47&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;23&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;046&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Rotterdam<a class="elsevierStyleCrossRef" href="#tbl3fn4"><span class="elsevierStyleSup">d</span></a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15 &#40;37&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;20&#46;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;097&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">20 &#40;51&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">7 &#40;21&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
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            1 => array:3 [
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            2 => array:3 [
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Article information

ISSN: 16652681
Original language: English

DOI:10.5604/01.3001.0009.8598

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Year/Month	Html	Pdf	Total

2024 November	5	0	5
2024 October	29	2	31
2024 September	38	1	39
2024 August	45	4	49
2024 July	41	4	45
2024 June	50	3	53
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2024 April	43	9	52
2024 March	49	8	57
2024 February	45	7	52
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2023 December	39	9	48
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2023 October	35	15	50
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2023 April	61	3	64
2023 March	33	8	41
2023 February	17	7	24
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2022 December	26	7	33
2022 November	32	10	42
2022 October	31	7	38
2022 September	51	16	67
2022 August	45	7	52
2022 July	28	8	36
2022 June	32	10	42
2022 May	31	6	37
2022 April	37	11	48
2022 March	69	9	78
2022 February	57	7	64
2022 January	94	8	102
2021 December	42	10	52
2021 November	47	13	60
2021 October	50	7	57
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2021 July	23	6	29
2021 June	30	12	42
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2021 April	75	15	90
2021 March	52	6	58
2021 February	35	15	50
2021 January	27	18	45
2020 December	27	7	34
2020 November	37	7	44
2020 October	29	2	31
2020 September	27	19	46
2020 August	23	6	29
2020 July	20	6	26
2020 June	12	5	17
2020 May	24	14	38
2020 April	11	11	22
2020 March	24	5	29
2020 February	24	8	32
2020 January	34	5	39
2019 December	32	10	42
2019 November	30	7	37
2019 October	13	4	17
2019 September	18	3	21
2019 August	5	1	6
2019 July	10	4	14
2019 June	11	4	15
2019 May	1	6	7

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