was read the article
array:24 [ "pii" => "S166526811931659X" "issn" => "16652681" "doi" => "10.1016/S1665-2681(19)31659-X" "estado" => "S300" "fechaPublicacion" => "2010-04-01" "aid" => "71345" "copyright" => "Fundación Clínica Médica Sur, A.C." "copyrightAnyo" => "2010" "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Ann Hepatol. 2010;9:181-5" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 56 "formatos" => array:3 [ "EPUB" => 6 "HTML" => 31 "PDF" => 19 ] ] "itemSiguiente" => array:19 [ "pii" => "S1665268119316606" "issn" => "16652681" "doi" => "10.1016/S1665-2681(19)31660-6" "estado" => "S300" "fechaPublicacion" => "2010-04-01" "aid" => "71346" "copyright" => "Fundación Clínica Médica Sur, A.C." "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Ann Hepatol. 2010;9:186-91" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 51 "formatos" => array:3 [ "EPUB" => 13 "HTML" => 13 "PDF" => 25 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Neuroendocrine metastatic tumors of the liver resembling hepatocellular carcinoma" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "186" "paginaFinal" => "191" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 740 "Ancho" => 1000 "Tamanyo" => 123888 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Neuroendocrine metastatic neoplasm to the liver with extensive fibrotic stroma.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Julián Arista-Nasr, Jose Antonio Fernández-Amador, Braulio Martínez-Benítez, Jazmín de Anda-González, Leticia Bornstein-Quevedo" "autores" => array:5 [ 0 => array:3 [ "preGrado" => "MD" "nombre" => "Julián" "apellidos" => "Arista-Nasr" ] 1 => array:2 [ "nombre" => "Jose" "apellidos" => "Antonio Fernández-Amador" ] 2 => array:2 [ "nombre" => "Braulio" "apellidos" => "Martínez-Benítez" ] 3 => array:2 [ "nombre" => "Jazmín" "apellidos" => "de Anda-González" ] 4 => array:2 [ "nombre" => "Leticia" "apellidos" => "Bornstein-Quevedo" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268119316606?idApp=UINPBA00004N" "url" => "/16652681/0000000900000002/v1_201907070740/S1665268119316606/v1_201907070740/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1665268119316588" "issn" => "16652681" "doi" => "10.1016/S1665-2681(19)31658-8" "estado" => "S300" "fechaPublicacion" => "2010-04-01" "aid" => "71344" "copyright" => "Fundación Clínica Médica Sur, A.C." "documento" => "article" "crossmark" => 0 "licencia" => "http://creativecommons.org/licenses/by-nc-nd/4.0/" "subdocumento" => "fla" "cita" => "Ann Hepatol. 2010;9:177-80" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 52 "formatos" => array:3 [ "EPUB" => 7 "HTML" => 22 "PDF" => 23 ] ] "en" => array:11 [ "idiomaDefecto" => true "titulo" => "Serum concentrations of substance P in cholestasis" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "177" "paginaFinal" => "180" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 606 "Ancho" => 1002 "Tamanyo" => 28123 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Mean ± SE serum concentrations of substance P in the study groups. The mean serum concentration of substance P in the group of patients with chronic liver disease (CLD) and pruritus (n = 13) was significantly higher than that of patients with chronic liver disease without pruritus (n = 17), (p < 0.0001), and that of the control group of subjects (n = 12) (p < 0.0001). The mean serum concentration of substance P from the group of patients with cholestasis without pruritus was not significantly different from that of the control group of subjects.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Mayur Trivedi, Nora V. Bergasa" "autores" => array:2 [ 0 => array:2 [ "nombre" => "Mayur" "apellidos" => "Trivedi" ] 1 => array:3 [ "preGrado" => "M.D." "nombre" => "Nora" "apellidos" => "V. Bergasa" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268119316588?idApp=UINPBA00004N" "url" => "/16652681/0000000900000002/v1_201907070740/S1665268119316588/v1_201907070740/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "titulo" => "Anti-parietal cell autoantibodies (PCA) in primary biliary cirrhosis: a putative marker for recurrence after orthotopic liver transplantation?" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "181" "paginaFinal" => "185" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Sandra Ciesek, Thomas Becker, Michael P. Manns, Christian P. Strassburg" "autores" => array:4 [ 0 => array:3 [ "nombre" => "Sandra" "apellidos" => "Ciesek" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff1" ] ] ] 1 => array:3 [ "nombre" => "Thomas" "apellidos" => "Becker" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "Michael P." "apellidos" => "Manns" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff1" ] ] ] 3 => array:4 [ "preGrado" => "MD" "nombre" => "Christian P." "apellidos" => "Strassburg" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Department of Gastroenterology, Hepatology and Endocrinology, Medical School, Hannover, Germany" "etiqueta" => "*" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Department of General, Visceral and Transplant Surgery, Medical School, Hannover, Germany" "etiqueta" => "**" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence and reprint request:" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "f0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1530 "Ancho" => 998 "Tamanyo" => 115231 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">A.</span> Detection of αnti-PCA: Anti-PCA was significantly more frequent in patients with PBC recurrence after liver transplantation but also in those PBC patients that developed recurrence before OLT (* p < 0.01). <span class="elsevierStyleBold">B.</span> Recurrence-free survival curves after liver transplantation for PCA positive and negative patients with PBC: While all patients with PCA develop PBC recurrence within 15 years after OLT, none of the PCA negative patients showed clinical signs of PBC recurrence.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="p0005" class="elsevierStylePara elsevierViewall">Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by the destruction of interlobular and septal bile ducts, leading to the development of fibrosis and cirrhosis.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> Genetic susceptibility as a predisposing factor for PBC has been suggested and involves MHC and non-MHC genes.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> In addition environmental factors have been suggested to include infectious and environmental etiologies.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> The diagnosis is based on a combination of clinical features, abnormal liver biochemical pattern in a cholestatic picture persisting for more than six months and presence of detectable antimitochondrial antibodies (AMA) in serum directed against PHD-E2 antigen.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> Orthotopic liver transplantation (OLT) remains the definitive treatment for decompensated liver disease secondary to PBC. OLT for primary biliary cirrhosis is characterized by disease recurrence with typical clinical, biochemical, and histologic changes in up to one third of pa-tients.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Although the presence of recurrent PBC does not appear to affect either graft or patient survival rates as severely as in HCV and PSC, the diagnosis of recurrence requires a cholestatic profile and a typical histology representing a challenge for transplant hepatologists. Previous studies identified donor and recipient age and warm/cold ischemic time as a risk factor for PBC recurrence.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> While the initial diagnosis is based on antimitochondrial antibodies (AMA), which persist after OLT<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> they are thus of limited value for the diagnosis of PBC re-currence.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Aim of this study was to identify autoimmune serological parameters associated with recurrent PBC.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Patients and Methods</span><p id="p0010" class="elsevierStylePara elsevierViewall">All patients who previously had undergone liver transplantation at the Hannover Medical School between 1992 and 2006 were evaluated. Of those, 72 patients underwent liver transplantation with histologically confirmed PBC. Post-transplantation immunosuppressive therapy included cyclosporine A or tacrolimus, corticosteroids and/or mycophenolate mofetil. Cyclosporine A doses were adjusted to maintenance blood levels between 100-200 ng/mL. Tacrolimus doses were adjusted to maintenance blood levels between 5-15 ng/mL. Methylprednisolone was given as a bolus injection of 500 mg at the time of reperfu-sion, and 250 mg were administered six hours post-operatively. Prednisolone was started at 100 mg orally on day 1 after OLT and then individually tapered down to 5-7.5 mg. In addition, some patients also received azathioprin, mycophenolate mofetil or monoclonal anti-interleukin-2 receptor antibodies.</p><p id="p0015" class="elsevierStylePara elsevierViewall">All 72 patients with histologically confirmed PBC were analysed for the following autoimmune serolo-gical parameters: antimitochondrial antibodies (AMA), antinuclear antibodies (ANA), anti parietal cell antibodies (anti PCA), anti-soluble liver antigen (SLA), anti liver-kidney-microsome antibody (LKM) and anti-pyruvate dehydrogenase-E2 (anti PHD-E2) before and after OLT. Indirect immunofluorescence was used for the detection of AMA, anti PHD-E2, ANA, PCA, SLA, anti-LKM antibodies as previously described.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Titers above 1:80 were considered to be significantly positive. Additionally, we studied im-munosuppressive therapy and outcome of these patients.</p><p id="p0020" class="elsevierStylePara elsevierViewall">Gold standard for the diagnosis of recurrent PBC was a liver biopsy demonstrating the characteristic histologic features. Patients did not receive routine biopsies, but the indication for liver histology was indication-based. Recurrent PBC was based on the presence of epitheloid granulomas, florid bile duct lesions, bile duct injury, and lymphoid aggregates in liver specimens, and biochemical cholestasis.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Other pathology or disorders such as acute and chronic rejection, graft versus host disease, biliary obstruction, cholangitis and other infections, viral hepatitis or drug toxicity were excluded.</p><p id="p0025" class="elsevierStylePara elsevierViewall">Furthermore during pre OLT diagnostic work-up all patients received an upper intestinal endoscopy, which included a histological assessment of gastric mucosa in all 72 patients and therefore the opportunity to detect <span class="elsevierStyleItalic">H. pylori</span> infection. <span class="elsevierStyleItalic">H. pylori</span> was identified following standard microbiology and biochemical techniques.</p></span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Results</span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Patient and graft survival</span><p id="p0030" class="elsevierStylePara elsevierViewall">Between 1992 and 2006 72 patients (68 female, 4 male) underwent OLT with histologically confirmed PBC. Median follow up was 123 months. Five patients died because of sepsis (2), cerebral vascular attack (1), or cholestatic liver failure (2) within 11 years after OLT, 2 patients required re-transplantation because of bile duct necrosis and thrombosis of the hepatic artery (11 months and 1 month after liver transplantation). Overall patient survival was 85.67.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Autoantibodies after liver transplantation</span><p id="p0035" class="elsevierStylePara elsevierViewall">Nearly all patients (94%) were AMA positive before liver transplantation, while only 6% were negative before OLT. Interestingly, AMA persisted in 55 (76%) patients after OLT <a class="elsevierStyleCrossRef" href="#f0005">Figure 1</a>, <a class="elsevierStyleCrossRef" href="#t0005">Table 1A</a>). Anti-PDH-E2 directed AMA was positive in 26 out of 66 (39%) patients before and in 27 out of 64 patients (42%) after OLT.</p><elsevierMultimedia ident="f0005"></elsevierMultimedia><elsevierMultimedia ident="t0005"></elsevierMultimedia><p id="p0040" class="elsevierStylePara elsevierViewall">ANA were detectable in 17 out of 72 patients before and in 21 patients after OLT (<a class="elsevierStyleCrossRef" href="#t0005">Table 1A</a>). 28 out of 68 patients had anti-parietal cell antibodies (PCA, 41%) before and 34 out of 72 patients (47%) had PCA after OLT.</p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Recurrence of primary biliary cirrhosis after liver transplantation</span><p id="p0045" class="elsevierStylePara elsevierViewall">Liver biopsies were obtained in 34 patients post OLT upon clinical suspicion, and recurrent PBC diagnosed in 20/72 (28%) after a mean of 71 months (range 13-161) (<a class="elsevierStyleCrossRef" href="#t0010">Table 1B</a>). Interestingly, anti-PCA were detected in 100% of patients with recurrence before and following transplantation (<a class="elsevierStyleCrossRef" href="#f0010">Figure 2</a>). Furthermore 15 out of 28 patients with anti-PCA before OLT (54%) developed recurrence during follow-up.</p><elsevierMultimedia ident="t0010"></elsevierMultimedia><elsevierMultimedia ident="f0010"></elsevierMultimedia></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Immunosuppression</span><p id="p0050" class="elsevierStylePara elsevierViewall">51 patients (71%) received cyclosporine A and 21 patients (29%) tacrolimus as primary immunosu-ppressive agents. From the 20 patients with PBC recurrence after orthotopic liver transplantation, 12 patients had an immunosuppressive regime with ci-closporine (60%) and 8 patients received tacrolimus. There was no significant difference between initial immunosuppression of patients who developed PBC recurrence compared to the patients who did not develop PBC recurrence.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Incidence of <span class="elsevierStyleItalic">Helicobacter pylori</span></span><p id="p0055" class="elsevierStylePara elsevierViewall">Twenty-eight (38.8%) of the 72 patients were positive for <span class="elsevierStyleItalic">H. pylori.</span> The prevalence of <span class="elsevierStyleItalic">H. pylori</span> was not significantly different in the 20 patients, who suffered from PBC recurrence after OLT (40% <span class="elsevierStyleItalic">H. pylori</span> positive before OLT, <a class="elsevierStyleCrossRef" href="#t0005">Table 1A</a> and <a class="elsevierStyleCrossRef" href="#t0010">B</a>).</p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Discussion</span><p id="p0060" class="elsevierStylePara elsevierViewall">Although overall survival in a long-term study with a follow-up of approximately II years of patients with primary biliary cirrhosis after OLT is very good (85.6%), recurrent PBC was diagnosed in 28% of all patients. These data are in line with several other studies, which described PBC recurrence after orthotopic liver transplantation in up to one-third of patients.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="p0065" class="elsevierStylePara elsevierViewall">To predict recurrent disease, a number of putative risk factors such as donor and recipient age, cold and warm ischaemic time, and tacrolimus-based immuno-suppression, have been reported.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> However, the diagnosis remains a challenge to transplant hepatologists. In this study cohort no difference between tacroli-mus-based immunosuppression compared to immuno-suppression with cyclosporine A was observed regarding the prevalence of recurrent PBC.</p><p id="p0070" class="elsevierStylePara elsevierViewall">The analysis of the autoantibody profiles led to an interesting association not previously reported. Anti-PCA antibodies detected prior to transplantation were found to be significantly associated with PBC recurrence after OLT. While antimitochon-drial antibodies have a high specificity for PBC and serve as serological confirmation of the diagnosis,<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> they did not have a predictive function for the recurrence of PBC in this study, which is in line with several other studies which demonstrate that AMA had no influence of PBC recurrence.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Additional autoantibodies such as ANA and anti-PCA are detectable in a subgroup of PBC patients, but to date have limited diagnostic relevance other than in AMA-negative PBC, in which specific ANA exhibit a high specificity for the disease.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Consistent with these findings, we did not observe any significant differences in the number of ANA, anti-PDH-E2 or anti-PCA positive patients before and after OLT. Although unspecific for the diagnosis of PBC, anti-PCA prevalence increased slightly after OLT, and was present in all patients who suffered from recurrent PBC. Recurrent PBC developed in 54% of patients with anti-PCA before OLT. This observation should be approved in a future prospective trial in order to find out if these autoantibodies may represent a simple and cost effective diagnostic marker for the likelihood of PBC recurrences after OLT. Importantly, we could not detect any correlation between disease recurrence after OLT and PCA antibodies in 14 patients with autoimmune hepatitis (AIH): out of 5 patients with AIH recurrence after OLT only one had detectable PCA antibodies (data not shown).</p><p id="p0075" class="elsevierStylePara elsevierViewall">PCA have been primarily described in autoimmune atrophic gastritis and in atrophic gastritis following helicobacter infection. PCA autoantibodies have been associated with the severity of gastritis, gastric mucosa atrophy as well as with apoptosis of the mucosa of the gastric corpus.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> Human PCA sera react with recombinant H+, K+ ATPase.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> and may indicate an autoimmune reaction suggestive of the presence of H +,K+ ATPase specific T helper cells found in autoimmune gastritis[18]. From a clinical point of view PCA are classical markers associated with pernicious anemia and gastric atrophy. Since they have a high frequency of up to over 50% in H. pylori infected individuals an etiological link has been suggested.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">16</span></a><span class="elsevierStyleSup">,</span><a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> However, the role of <span class="elsevierStyleItalic">H. pylori</span> as a cause of autoimmune atrophic gastritis is controversially discussed.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> In many features atrophic gastritis after prolonged persistent <span class="elsevierStyleItalic">H. pylori</span> infection resembles autoimmune atrophic gastritis without <span class="elsevierStyleItalic">H. pylori</span> infection. In addition, PCA are detected in patients with atrophic gastritis and appear to correlate with disease activity and stage but are also detected in asymptomatic individuals with <span class="elsevierStyleItalic">H. pylori</span> infection. The relationship of PCA and PBC is unclear. T cell-mediated au-toreacitivity against transporter protein, which is also expressed in biliary epithelium may represent a link of these autoantibodies to PBC, which is primarily mediated by autoreactive T cells. In order to analyze the findings in respect to <span class="elsevierStyleItalic">Helicobacter</span> we evaluated, whether our cohort of PBC Helicobacter infection. None of the 72 patients had signs of atro-phic gastritis upon pre OLT gastroscopy. Interestingly, in this study, we also failed to detect significant differences of <span class="elsevierStyleItalic">H. pylori</span> prevalence between the PBC cohort with recurrence compared to all PBC patients after OLT, which is consistend with other studies.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> It is a diagnostically significant observation that PCA autoantibodies occurred in 41% of PBC patients before OLT and therefore appear to be associated with PBC, but in the group of recurrent PBC after OLT this marker was present in all patients.</p><p id="p0080" class="elsevierStylePara elsevierViewall">Our data suggest that PCA autoantibodies, which are not specific for PBC, appear to indicate a higher probability of PBC recurrence after OLT. If PCA may really represent a facile marker of risk stratification, should be evaluated in future prospective studies.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:7 [ 0 => array:3 [ "identificador" => "xres1217533" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abs0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1132914" "titulo" => "Key words" ] 2 => array:2 [ "identificador" => "sec0005" "titulo" => "Introduction" ] 3 => array:2 [ "identificador" => "sec0010" "titulo" => "Patients and Methods" ] 4 => array:3 [ "identificador" => "sec0015" "titulo" => "Results" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "sec0020" "titulo" => "Patient and graft survival" ] 1 => array:2 [ "identificador" => "sec0025" "titulo" => "Autoantibodies after liver transplantation" ] 2 => array:2 [ "identificador" => "sec0030" "titulo" => "Recurrence of primary biliary cirrhosis after liver transplantation" ] 3 => array:2 [ "identificador" => "sec0035" "titulo" => "Immunosuppression" ] 4 => array:2 [ "identificador" => "sec0040" "titulo" => "Incidence of Helicobacter pylori" ] ] ] 5 => array:2 [ "identificador" => "sec0045" "titulo" => "Discussion" ] 6 => array:1 [ "titulo" => "Reference" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec1132914" "palabras" => array:5 [ 0 => "Primary biliary cirrhosis" 1 => "Autoantibodies" 2 => "PCA" 3 => "Orthotopic liver transplantation" 4 => "Anti-parietal cell autoantibodies" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abs0005" class="elsevierStyleSection elsevierViewall"><p id="sp0025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Introduction.</span> Liver transplantation (OLT) for primary biliary cirrhosis (PBC) is characterized by disease recurrence of up to one third of patients. The diagnosis of recurrence requires a cholestatic profile and a typical histology representing a challenge for transplant hepatologists. Antimitochondrial antibodies (AMA) establish the initial diagnosis, persist after OLT, and are thus of limited value for the diagnosis of recurrence. Aim of this analysis was to identify serological parameters associated with recurrent PBC.</p><p id="sp1025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Patients and methods.</span> OLT performed between 1992 and 2006 at Hannover Medical School were evaluated retrospectively including histology before and after OLT, autoimmune serological parameters and clinical characteristics.</p><p id="sp2025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Results.</span> Between 1992 and 2006 72 patients underwent OLT with histologically confirmed PBC. Median follow up was 123 months. AMA persisted in 55 (767) patients. Anti-parietal cell antibodies (PCA) were detectable in 41% of the patients before and 47% after OLT. Liver biopsies were obtained in 34 patients post OLT upon clinical suspicion, and recurrent PBC diagnosed in 28% after a mean of 71 months (range 13-161). Anti-PCA were detected in 100% of patients with recurrence before and following transplantation, 54% of patients with anti-PCA before OLT developed recurrence during follow-up. There were no differences in immunosuppressive regimen.</p><p id="sp3025" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Discussion.</span> Although unspecific for the diagnosis of PBC, anti-PCA prevalence increased after OLT, and was 100% in patients with recurrent PBC. Recurrent PBC developed in 54% of patients with anti-PCA before OLT suggesting a diagnostic role of anti-PCA as a simple and cost effective marker of recurrence.</p></span>" ] ] "multimedia" => array:4 [ 0 => array:7 [ "identificador" => "f0005" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 664 "Ancho" => 999 "Tamanyo" => 41537 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0005" class="elsevierStyleSimplePara elsevierViewall">Detection of antibodies before and after orthotopic liver transplantation in patients with PBC. Indirect immunofluorescence was used for the detection of AMA, anti PHD-E2, PCA, antibodies as previously described.<span class="elsevierStyleSup">7</span> There was no significant difference in detection of AMA, anti PHD-E2 or PCA.</p>" ] ] 1 => array:7 [ "identificador" => "f0010" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 1530 "Ancho" => 998 "Tamanyo" => 115231 ] ] "descripcion" => array:1 [ "en" => "<p id="sp0010" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">A.</span> Detection of αnti-PCA: Anti-PCA was significantly more frequent in patients with PBC recurrence after liver transplantation but also in those PBC patients that developed recurrence before OLT (* p < 0.01). <span class="elsevierStyleBold">B.</span> Recurrence-free survival curves after liver transplantation for PCA positive and negative patients with PBC: While all patients with PCA develop PBC recurrence within 15 years after OLT, none of the PCA negative patients showed clinical signs of PBC recurrence.</p>" ] ] 2 => array:7 [ "identificador" => "t0005" "etiqueta" => "Table 1A" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"><span class="elsevierStyleBold">Age (in years):</span> SI (range 25-67) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"><span class="elsevierStyleBold">Sex:</span> 68 female/4 male \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"><span class="elsevierStyleBold">Median follow up (in moths):</span> 123 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">pre \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">post \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">AMA positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">68/72 (94%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">55/72 (76%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">ANA positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">17/72 24%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">21/72 (29%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">AntiPDHE2 positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">17/72 (24%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">21/72 (29%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">antiPCA positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">28/68 (41%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">34/72 (47%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">bilirubine (mg(dl_ \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">5.2 (1-52) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">1.8 (0.1-33) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">biopsy available \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">72/72 (100%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">34/72 (47%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle"><span class="elsevierStyleItalic">H. pylori</span> positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">28/72 (38.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">n.d \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2078588.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0015" class="elsevierStyleSimplePara elsevierViewall">Characteristics and antibody profile of 72 patients with PBC who underwent liver transplantation.</p>" ] ] 3 => array:7 [ "identificador" => "t0010" "etiqueta" => "Table 1B" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"><span class="elsevierStyleBold">Age (in years):</span> 52 (range 25-63) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"><span class="elsevierStyleBold">Sex:</span> 19 female/4 male \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"><span class="elsevierStyleBold">Median follow up (in moths):</span> 71 (13-161) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">pre \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">post \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">AMA positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">18/20 (90%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">16/20 (80%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">ANA positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">5/20 (25%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">6/20 (33%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">AntiPDHE2 positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">9/18 (50%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">8/16 (50%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle"><span class="elsevierStyleBold">antiPCA positive</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle"><span class="elsevierStyleBold">20/20 (100%)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle"><span class="elsevierStyleBold">20/20 (100%)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">bilirubine (mg(dL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">8.6 (5-52) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">9.8 (5.6-33) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">biopsy available \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">20/20 (100%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">20/20 (100%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle"><span class="elsevierStyleItalic">H. pylori</span> positive \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">8/20 (40%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="middle">n.d \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2078589.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="sp0020" class="elsevierStyleSimplePara elsevierViewall">Characteristics and antibody profile of 30 patients with recurrence of PBC post liver transplantation.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "Reference" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bs0005" "bibliografiaReferencia" => array:21 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recurrent primary biliary cirrhosis after liver transplantation-the disease and its management" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Schreibman I." 1 => "Regev A." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "MedGenMed" "fecha" => "2006" "volumen" => "8" "numero" => "2" "paginaInicial" => "30" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17415312" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "HLA and interleukin 1 gene polymorphisms in primary biliary cirrhosis: associations with disease progression and disease susceptibility" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Donaldson P." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/gut.48.3.397" "Revista" => array:7 [ "tituloSerie" => "Gut" "fecha" => "2001" "volumen" => "48" "numero" => "3" "paginaInicial" => "397" "paginaFinal" => "402" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11171832" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relation between Escherichia coli R(rough)-forms in gut, lipid A in liver, and primary biliary cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Hopf U." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0140-6736(89)92034-5" "Revista" => array:7 [ "tituloSerie" => "Lancet" "fecha" => "1989" "volumen" => "2" "numero" => "8677" "paginaInicial" => "1419" "paginaFinal" => "1422" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2574361" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The causes of primary biliary cirrhosis: Convenient and inconvenient truths" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Gershwin M.E." 1 => "Mackay I.R." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/hep.22042" "Revista" => array:7 [ "tituloSerie" => "Hepatology" "fecha" => "2008" "volumen" => "47" "numero" => "2" "paginaInicial" => "737" "paginaFinal" => "745" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18098322" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary biliary cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Kumagi T." 1 => "Heathcote E.J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1186/1750-1172-3-1" "Revista" => array:5 [ "tituloSerie" => "Orphanet J Rare Dis" "fecha" => "2008" "volumen" => "3" "paginaInicial" => "1" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18215315" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autoimmune tests in primary biliary cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Strassburg C.P." 1 => "Manns M.P." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/bega.2000.0105" "Revista" => array:7 [ "tituloSerie" => "Baillieres Best Pract Res Clin Gastroenterol" "fecha" => "2000" "volumen" => "14" "numero" => "4" "paginaInicial" => "585" "paginaFinal" => "599" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10976016" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Long-term follow-up after recurrence of primary biliary cirrhosis after liver transplantation in 100 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Jacob D.A." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1399-0012.2005.00471.x" "Revista" => array:7 [ "tituloSerie" => "Clin Transplant" "fecha" => "2006" "volumen" => "20" "numero" => "2" "paginaInicial" => "211" "paginaFinal" => "220" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16640529" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0040" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recurrent primary biliary cirrhosis: peri-transplant factors and ursodeoxycholic acid treatment post-liver transplant" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Guy J.E." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/lt.20511" "Revista" => array:7 [ "tituloSerie" => "Liver Transpl" "fecha" => "2005" "volumen" => "11" "numero" => "10" "paginaInicial" => "1252" "paginaFinal" => "1257" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16184542" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0045" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of autoantibodies to recombinant mitochondrial proteins in patients with primary biliary cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Van de Water J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJM198905253202104" "Revista" => array:7 [ "tituloSerie" => "N Engl J Med" "fecha" => "1989" "volumen" => "320" "numero" => "21" "paginaInicial" => "1377" "paginaFinal" => "1380" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2716784" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0050" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Serological Tests In Diagnosis Of Primary Biliary Cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Walker J.G." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0140-6736(89)92281-2" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1965" "volumen" => "1" "paginaInicial" => "827" "paginaFinal" => "831" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2564911" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0055" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recurrent primary biliary cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Neuberger J." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/bega.2000.0111" "Revista" => array:7 [ "tituloSerie" => "Baillieres Best Pract Res Clin Gastroenterol" "fecha" => "2000" "volumen" => "14" "numero" => "4" "paginaInicial" => "669" "paginaFinal" => "680" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10976022" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0060" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of cyclin A as a molecular target of antinuclear antibodies (ANA) in hepatic and non-hepatic autoimmune diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Strassburg C.P." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Hepatol" "fecha" => "1996" "volumen" => "25" "numero" => "6" "paginaInicial" => "859" "paginaFinal" => "866" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9007714" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib0065" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anti-mitochondrial antibodies and other immunological tests in primary biliary cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "Strassburg C.P." 1 => "Jaeckel E." 2 => "Manns M.P." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur J Gastroenterol Hepatol" "fecha" => "1999" "volumen" => "11" "numero" => "6" "paginaInicial" => "595" "paginaFinal" => "601" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10418929" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib0070" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Autoantibodies and autoantigens in autoimmune hepatitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "Strassburg C.P." 1 => "Manns M.P." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-2002-35704" "Revista" => array:7 [ "tituloSerie" => "Semin Liver Dis" "fecha" => "2002" "volumen" => "22" "numero" => "4" "paginaInicial" => "339" "paginaFinal" => "352" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12447706" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib0075" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of non-organ-specific autoantibodies in patients suffering from duodenal ulcer with and without Helicobacter pylori infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Pellicano R." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Dig Dis Sci" "fecha" => "2004" "volumen" => "49" "numero" => "3" "paginaInicial" => "395" "paginaFinal" => "398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15139486" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib0080" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Presence of gastric autoantibodies impairs gastric secretory function in patients with Helico-bacter pylori-positive duodenal ulcer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Parente F." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Scand J Gastroenterol" "fecha" => "2001" "volumen" => "36" "numero" => "5" "paginaInicial" => "474" "paginaFinal" => "478" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11346199" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib0085" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The gastric H+,K+-ATPase is a major autoantigen in chronic Helicobacter pylori gastritis with body mucosa atrophy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Claeys D." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Gastroenterology" "fecha" => "1998" "volumen" => "115" "numero" => "2" "paginaInicial" => "340" "paginaFinal" => "347" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9679039" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib0090" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evidence of novel pathogenic pathways for the formation of antigastric autoantibodies in Helicobacter pylori gastritis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Faller G." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/jcp.51.3.244" "Revista" => array:7 [ "tituloSerie" => "J Clin Pathol" "fecha" => "1998" "volumen" => "51" "numero" => "3" "paginaInicial" => "244" "paginaFinal" => "245" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9659270" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib0095" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Two-thirds of atrophic body gastritis patients have evidence of Helicobacter pylori infection" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Annibale B." ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Helicobacter" "fecha" => "2001" "volumen" => "6" "numero" => "3" "paginaInicial" => "225" "paginaFinal" => "233" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11683925" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib0100" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The story so far: Helicobacter pylori and gastric autoimmunity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Bergman M.P." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1080/08830180590884648" "Revista" => array:7 [ "tituloSerie" => "Int Rev Immunol" "fecha" => "2005" "volumen" => "24" "numero" => "1-2" "paginaInicial" => "63" "paginaFinal" => "91" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15763990" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib0105" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lack of association between seroprevalence of Helicobacter pylori infection and primary biliary cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:1 [ 0 => "Durazzo M." ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.3748/wjg.v10.i21.3179" "Revista" => array:7 [ "tituloSerie" => "World J Gastroenterol" "fecha" => "2004" "volumen" => "10" "numero" => "21" "paginaInicial" => "3179" "paginaFinal" => "3181" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15457568" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/0000000900000002/v1_201907070740/S166526811931659X/v1_201907070740/en/main.assets" "Apartado" => array:4 [ "identificador" => "77721" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Original Article" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/16652681/0000000900000002/v1_201907070740/S166526811931659X/v1_201907070740/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S166526811931659X?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 5 | 0 | 5 |
2024 October | 86 | 11 | 97 |
2024 September | 64 | 18 | 82 |
2024 August | 56 | 22 | 78 |
2024 July | 105 | 12 | 117 |
2024 June | 55 | 9 | 64 |
2024 May | 81 | 17 | 98 |
2024 April | 68 | 11 | 79 |
2024 March | 92 | 16 | 108 |
2024 February | 65 | 27 | 92 |
2024 January | 79 | 16 | 95 |
2023 December | 59 | 4 | 63 |
2023 November | 90 | 17 | 107 |
2023 October | 88 | 8 | 96 |
2023 September | 61 | 2 | 63 |
2023 August | 63 | 4 | 67 |
2023 July | 49 | 7 | 56 |
2023 June | 52 | 4 | 56 |
2023 May | 72 | 1 | 73 |
2023 April | 67 | 3 | 70 |
2023 March | 57 | 2 | 59 |
2023 February | 29 | 4 | 33 |
2023 January | 27 | 2 | 29 |
2022 December | 32 | 5 | 37 |
2022 November | 40 | 2 | 42 |
2022 October | 39 | 5 | 44 |
2022 September | 38 | 8 | 46 |
2022 August | 44 | 8 | 52 |
2022 July | 25 | 5 | 30 |
2022 June | 25 | 11 | 36 |
2022 May | 19 | 6 | 25 |
2022 April | 27 | 10 | 37 |
2022 March | 18 | 8 | 26 |
2022 February | 13 | 3 | 16 |
2022 January | 25 | 8 | 33 |
2021 December | 19 | 8 | 27 |
2021 November | 16 | 8 | 24 |
2021 October | 31 | 8 | 39 |
2021 September | 15 | 8 | 23 |
2021 August | 8 | 5 | 13 |
2021 July | 15 | 9 | 24 |
2021 June | 13 | 6 | 19 |
2021 May | 10 | 7 | 17 |
2021 April | 24 | 11 | 35 |
2021 March | 4 | 8 | 12 |
2021 February | 5 | 3 | 8 |
2021 January | 9 | 5 | 14 |
2020 December | 4 | 6 | 10 |
2020 November | 2 | 5 | 7 |
2020 October | 6 | 4 | 10 |
2020 September | 8 | 6 | 14 |
2020 August | 8 | 2 | 10 |
2020 July | 2 | 1 | 3 |
2020 June | 2 | 1 | 3 |
2020 May | 5 | 4 | 9 |
2020 April | 4 | 2 | 6 |
2020 March | 4 | 1 | 5 |
2020 February | 2 | 3 | 5 |
2020 January | 8 | 3 | 11 |
2019 December | 5 | 5 | 10 |
2019 November | 2 | 1 | 3 |
2019 October | 2 | 2 | 4 |
2019 September | 4 | 1 | 5 |
2019 August | 4 | 1 | 5 |
2019 July | 5 | 4 | 9 |