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array:22 [ "pii" => "S1665268123003101" "issn" => "16652681" "doi" => "10.1016/j.aohep.2023.101207" "estado" => "S300" "fechaPublicacion" => "2024-02-01" "aid" => "101187.20" "copyrightAnyo" => "2023" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2024;29 Supl 1:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:17 [ "pii" => "S1665268123003113" "issn" => "16652681" "doi" => "10.1016/j.aohep.2023.101208" "estado" => "S300" "fechaPublicacion" => "2024-02-01" "aid" => "101187.21" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2024;29 Supl 1:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "P-21 FIBROSIS DEVELOPMENT AND MALIGNANCIES ARE DELAYED BY PIRFENIDONE WHILE INCREASING SIRT1 NUCLEAR TRANSLOCATION AND HISTONE 3 DEACETYLATIONS IN A HEPATOCARCINOMA MODEL" "tienePdf" => "en" "tieneTextoCompleto" => 0 "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Hugo Christian Monroy, Scarlet Arceo, Araceli Guadalupe Cabral, Marina Galicia, Juan Armendariz" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Hugo Christian" "apellidos" => "Monroy" ] 1 => array:2 [ "nombre" => "Scarlet" "apellidos" => "Arceo" ] 2 => array:2 [ "nombre" => "Araceli Guadalupe" "apellidos" => "Cabral" ] 3 => array:2 [ "nombre" => "Marina" "apellidos" => "Galicia" ] 4 => array:2 [ "nombre" => "Juan" "apellidos" => "Armendariz" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123003113?idApp=UINPBA00004N" "url" => "/16652681/00000029000000S1/v2_202405310451/S1665268123003113/v2_202405310451/en/main.assets" ] "itemAnterior" => array:17 [ "pii" => "S1665268123003095" "issn" => "16652681" "doi" => "10.1016/j.aohep.2023.101206" "estado" => "S300" "fechaPublicacion" => "2024-02-01" "aid" => "101187.19" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "abs" "cita" => "Ann Hepatol. 2024;29 Supl 1:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "titulo" => "P-19 CHARACTERIZATION, PROGNOSTIC FACTORS, AND SURVIVAL IN MODERATE ALCOHOL-ASSOCIATED HEPATITIS: A MULTICENTER STUDY" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francisco Idalsoaga, Luis Antonio Díaz, Oscar Corsi, Gustavo Ayares, Jorge Arnold, Winston Dunn, Yanming Li, Ashwani Singal, Doug Simonetto, María Ayala-Valverde, Carolina A. Ramirez, Dalia Morales-Arraez, Wei Zhang, Steve Qian, Joseph Ahn, Seth Buryska, Heer Mehta, Muhammad Waleed, Horia Stefanescu, Adelina Horhat, Andreea Bumbu, Bashar Attar, Rohit Agrawal, Joaquín Cabezas, Berta Cuyàs, Maria Poca, German Soriano Pastor, Shiv K Sarin, Rakhi Maiwall, Prasun K Jalal, María Fátima Higuera-De La Tijera, Anand Kulkarni, Nagaraja Rao, Patricia Guerra Salazar, Lubomir Skladaný, Natália Bystrianska, Veronica Prado, Ana Clemente-Sanchez, Diego Rincón, Tehseen Haider, Kristina R Chacko, Gustavo A Romero, Florencia D Pollarsky, Juan Carlos Restrepo, Luis G Toro, Pamela Yaquich, Manuel Mendizabal, Maria Laura Garrido, Sebastian Marciano, Melisa Dirchwolf, Victor Vargas, Cesar Jimenez, Guadalupe García-Tsao, Guillermo Ortiz, Juan G Abraldes, Patrick Kamath, Vijay Shah, Ramon Bataller, Juan Pablo Arab" "autores" => array:59 [ 0 => array:2 [ "nombre" => "Francisco" "apellidos" => "Idalsoaga" ] 1 => array:2 [ "nombre" => "Luis Antonio" "apellidos" => "Díaz" ] 2 => array:2 [ "nombre" => "Oscar" "apellidos" => "Corsi" ] 3 => array:2 [ "nombre" => "Gustavo" "apellidos" => "Ayares" ] 4 => array:2 [ "nombre" => "Jorge" "apellidos" => "Arnold" ] 5 => array:2 [ "nombre" => "Winston" "apellidos" => "Dunn" ] 6 => array:2 [ "nombre" => "Yanming" "apellidos" => "Li" ] 7 => array:2 [ "nombre" => "Ashwani" "apellidos" => "Singal" ] 8 => array:2 [ "nombre" => "Doug" "apellidos" => "Simonetto" ] 9 => array:2 [ "nombre" => "María" "apellidos" => "Ayala-Valverde" ] 10 => array:2 [ "nombre" => "Carolina A." "apellidos" => "Ramirez" ] 11 => array:2 [ "nombre" => "Dalia" "apellidos" => "Morales-Arraez" ] 12 => array:2 [ "nombre" => "Wei" "apellidos" => "Zhang" ] 13 => array:2 [ "nombre" => "Steve" "apellidos" => "Qian" ] 14 => array:2 [ "nombre" => "Joseph" "apellidos" => "Ahn" ] 15 => array:2 [ "nombre" => "Seth" "apellidos" => "Buryska" ] 16 => array:2 [ "nombre" => "Heer" "apellidos" => "Mehta" ] 17 => array:2 [ "nombre" => "Muhammad" "apellidos" => "Waleed" ] 18 => array:2 [ "nombre" => "Horia" "apellidos" => "Stefanescu" ] 19 => array:2 [ "nombre" => "Adelina" "apellidos" => "Horhat" ] 20 => array:2 [ "nombre" => "Andreea" "apellidos" => "Bumbu" ] 21 => array:2 [ "nombre" => "Bashar" "apellidos" => "Attar" ] 22 => array:2 [ "nombre" => "Rohit" "apellidos" => "Agrawal" ] 23 => array:2 [ "nombre" => "Joaquín" "apellidos" => "Cabezas" ] 24 => array:2 [ "nombre" => "Berta" "apellidos" => "Cuyàs" ] 25 => array:2 [ "nombre" => "Maria" "apellidos" => "Poca" ] 26 => array:2 [ "nombre" => "German Soriano" "apellidos" => "Pastor" ] 27 => array:2 [ "nombre" => "Shiv K" "apellidos" => "Sarin" ] 28 => array:2 [ "nombre" => "Rakhi" "apellidos" => "Maiwall" ] 29 => array:2 [ "nombre" => "Prasun K" "apellidos" => "Jalal" ] 30 => array:2 [ "nombre" => "María Fátima Higuera-De La" "apellidos" => "Tijera" ] 31 => array:2 [ "nombre" => "Anand" "apellidos" => "Kulkarni" ] 32 => array:2 [ "nombre" => "Nagaraja" "apellidos" => "Rao" ] 33 => array:2 [ "nombre" => "Patricia Guerra" "apellidos" => "Salazar" ] 34 => array:2 [ "nombre" => "Lubomir" "apellidos" => "Skladaný" ] 35 => array:2 [ "nombre" => "Natália" "apellidos" => "Bystrianska" ] 36 => array:2 [ "nombre" => "Veronica" "apellidos" => "Prado" ] 37 => array:2 [ "nombre" => "Ana" "apellidos" => "Clemente-Sanchez" ] 38 => array:2 [ "nombre" => "Diego" "apellidos" => "Rincón" ] 39 => array:2 [ "nombre" => "Tehseen" "apellidos" => "Haider" ] 40 => array:2 [ "nombre" => "Kristina R" "apellidos" => "Chacko" ] 41 => array:2 [ "nombre" => "Gustavo A" "apellidos" => "Romero" ] 42 => array:2 [ "nombre" => "Florencia D" "apellidos" => "Pollarsky" ] 43 => array:2 [ "nombre" => "Juan Carlos" "apellidos" => "Restrepo" ] 44 => array:2 [ "nombre" => "Luis G" "apellidos" => "Toro" ] 45 => array:2 [ "nombre" => "Pamela" "apellidos" => "Yaquich" ] 46 => array:2 [ "nombre" => "Manuel" "apellidos" => "Mendizabal" ] 47 => array:2 [ "nombre" => "Maria Laura" "apellidos" => "Garrido" ] 48 => array:2 [ "nombre" => "Sebastian" "apellidos" => "Marciano" ] 49 => array:2 [ "nombre" => "Melisa" "apellidos" => "Dirchwolf" ] 50 => array:2 [ "nombre" => "Victor" "apellidos" => "Vargas" ] 51 => array:2 [ "nombre" => "Cesar" "apellidos" => "Jimenez" ] 52 => array:2 [ "nombre" => "Guadalupe" "apellidos" => "García-Tsao" ] 53 => array:2 [ "nombre" => "Guillermo" "apellidos" => "Ortiz" ] 54 => array:2 [ "nombre" => "Juan G" "apellidos" => "Abraldes" ] 55 => array:2 [ "nombre" => "Patrick" "apellidos" => "Kamath" ] 56 => array:2 [ "nombre" => "Vijay" "apellidos" => "Shah" ] 57 => array:2 [ "nombre" => "Ramon" "apellidos" => "Bataller" ] 58 => array:2 [ "nombre" => "Juan Pablo" "apellidos" => "Arab" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123003095?idApp=UINPBA00004N" "url" => "/16652681/00000029000000S1/v2_202405310451/S1665268123003095/v2_202405310451/en/main.assets" ] "en" => array:8 [ "idiomaDefecto" => true "titulo" => "P-20 OXIDATIVE STRESS MARKERS IN ALCOHOLIC LIVER DISEASE" "tieneTextoCompleto" => 0 "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "GABRIELA GUTIÉRREZ, Abigail Hernandez, Zaira Medina, Marisela Hernandez, Moisés Martínez, José Luis Pérez, Fátima Higuera, Jacqueline Córdova" "autores" => array:8 [ 0 => array:3 [ "nombre" => "GABRIELA" "apellidos" => "GUTIÉRREZ" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 1 => array:3 [ "nombre" => "Abigail" "apellidos" => "Hernandez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 2 => array:3 [ "nombre" => "Zaira" "apellidos" => "Medina" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 3 => array:3 [ "nombre" => "Marisela" "apellidos" => "Hernandez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 4 => array:3 [ "nombre" => "Moisés" "apellidos" => "Martínez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "aff0001" ] ] ] 5 => array:3 [ "nombre" => "José Luis" "apellidos" => "Pérez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002" ] ] ] 6 => array:3 [ "nombre" => "Fátima" "apellidos" => "Higuera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">2</span>" "identificador" => "aff0002" ] ] ] 7 => array:3 [ "nombre" => "Jacqueline" "apellidos" => "Córdova" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">3</span>" "identificador" => "aff0003" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Lab HIPAM, UIME, Facultad de Medicina, UNAM. Hospital General, Ciudad de México, México" "etiqueta" => "1" "identificador" => "aff0001" ] 1 => array:3 [ "entidad" => "Gastroenterología, Hospital General de México Dr. Eduardo Liceaga, Ciudad de México, México" "etiqueta" => "2" "identificador" => "aff0002" ] 2 => array:3 [ "entidad" => "Gastroenterología, Hospital General Manuel Gea Glz, Ciudad de México, México" "etiqueta" => "3" "identificador" => "aff0003" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="abss0001" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0001">Introduction and Objectives</span><p id="spara001" class="elsevierStyleSimplePara elsevierViewall">Several mechanisms participate in the physiopathology of Alcoholic Liver Disease (ALD), such as deregulation in the immune system and oxidative stress. Aim: To analyze markers of lipoperoxidation and oxidative proteins in patients with ALD: Alcohol hepatitis (AH) and liver cirrhosis (CiR).</p></span> <span id="abss0002" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0002">Materials and methods</span><p id="spara002" class="elsevierStyleSimplePara elsevierViewall">This transversal study included 220 individuals divided into three groups: the control group (n=100), individuals with alcohol consumption 10 g/day and AUDIT score 7, the group of AH patients (n=45) and CiR patients (n=75). We measured the serum levels of MDA (thiobarbituric acid method) and carbonylated proteins (DNPH reaction). The statistical analysis was performed by the SPSS v25 software. Data expressed as mean values ± SEM, p-value <0.05 was considered statistically significant.</p></span> <span id="abss0003" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0003">Results</span><p id="spara003" class="elsevierStyleSimplePara elsevierViewall">The control group (CT), with 30.47±0.52 years old, alcohol consumption of 2.32±0.21 gOH/day and AUDIT 2.24±0.10. The ALD patients, had 41.68±6.3 years old, consumption of 354.25±139.54 gOH/day and AUDIT 30±5.45. The AST, ALT, GGT, total and indirect bilirubin serum were higher in AH and CiR compared to CT (p<0.001), ratio of AST/ALT 2. The albumin levels were lower (p<0.001) in AH vs. CT. The carbonylated proteins serum concentrations were higher in patients with AH compared to CT and CiR (p<0.001). Differences in MDA serum levels were found between CiR versus HA and CT groups (p< 0.005).</p></span> <span id="abss0004" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cesectitle0004">Conclusions</span><p id="spara004" class="elsevierStyleSimplePara elsevierViewall">Our results suggest that carbonylated proteins and MDA are markers of oxidative damage in the alcohol hepatitis and liver cirrhosis Mexican patients. This damage may increase the risk of malnutrition, susceptibility to infections and sepsis, deficient coagulation factors production, gastrointestinal bleeding, among other complications that increase mortality. According these results is necessary to counteract oxidative damage for improving and complementing the actual treatment of alcoholic liver disease.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abss0001" "titulo" => "Introduction and Objectives" ] 1 => array:2 [ "identificador" => "abss0002" "titulo" => "Materials and methods" ] 2 => array:2 [ "identificador" => "abss0003" "titulo" => "Results" ] 3 => array:2 [ "identificador" => "abss0004" "titulo" => "Conclusions" ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/16652681/00000029000000S1/v2_202405310451/S1665268123003101/v2_202405310451/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/16652681/00000029000000S1/v2_202405310451/S1665268123003101/v2_202405310451/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1665268123003101?idApp=UINPBA00004N" ]
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