Frequency of bleeding due to ulcer associated with H. Pylori (HP) in patients with liver cirrhosis at Hospital Juárez de México

Introduction and Objectives

There are few clinical studies that report the prevalence of ulcers associated with H. pylori in cirrhotic patients determined by endoscopic biopsies 5% to 20% vs. 2%-4% of the general population. The risk of ulcer bleeding is higher in this group than in the general population. This study aimed to determine the frequency of ulcers due to HP as a cause of hemorrhage in patients with liver cirrhosis who were admitted to Gastroenterology from January 2022 to January 2023.

Materials and Methods

Descriptive, retrospective, observational and cross-sectional study of a cohort of cirrhotic patients hospitalized due to gastrointestinal bleeding secondary to an ulcer associated with H. pylori. Two hundred sixty-three endoscopies of cirrhotic patients were reviewed, excluding variceal hemorrhage, obtaining epidemiological data, cirrhosis etiology, biopsy report, and Child-pugh. Data are analyzed with measures of central tendency.

Results

Two hundred sixty-three reports reviewed; 40 due to ulcer with H.pylori (N=40), 57.5% men (n=23) average 51 years old, 42.5% women (n=17) average 61 years old. Cirrhosis due to alcohol consumption 57%, MAFLD 20%, Autoimmune 17.5%, HCV 7.5%. 7.2%, 92.5% of biopsies with HP activity, 55% duodenal and 45% gastric.

Discussion

15% of the cirrhotic patients presented hemorrhage due to duodenal or gastric ulcer associated with PH, more frequent in men with cirrhosis due to alcohol, Child-pugh A.

Conclusions

The association of ulcer bleeding with PH was presented in a percentage to be considered where the deterioration of liver function did not have an influence. However, the impact that has on the evolution, decompensation and prognosis of cirrhotic patients and the effectiveness of the treatment should be further investigated.

Funding

The resources used in this study were from the hospital without any additional financing

Declaration of interest

The authors declare no potential conflicts of interest.