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Journal Information
Vol. 88. Issue 4.
Pages 130-133 (April 2013)
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Vol. 88. Issue 4.
Pages 130-133 (April 2013)
Original article
Switching prostaglandin analogs and 24-h IOP fluctuations
Rotación de análogos de prostaglandinas y fluctuaciones diurnas de la presión intraocular
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1631
F. Gil-Carrasco
Corresponding author
fegica@hotmail.com

Corresponding author.
, M. Turati-Acosta, O. Albis-Donado, H. Bello-López-Portillo, C. Sánchez-Noguera, K. Soto-Ortiz
Departamento de Glaucoma, Asociación para evitar la ceguera en México, Hospital Dr. Luis Sánchez Bulnes, México City, Mexico
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Statistics
Figures (1)
Tables (3)
Table 1. Order of treatment for each stage.
Table 2. Intraocular pressure average values, highest, lowest and isolation average during the curves with each drug.
Table 3. Mean intraocular pressure at different times of the day and standard deviations.
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Abstract
Objectives

To evaluate the fluctuations in 24h mean intraocular pressure (IOP) when switching prostaglandin analogs in patients with glaucoma.

Methods

Fourteen patients with primary open angle glaucoma were evaluated with monthly 24-h IOP curves, using a monthly switching pattern of prostaglandin analogs and brinzolamide during 3 years of follow-up.

Results

Average IOP and average fluctuation (peak to through difference) were significantly higher with brinzolamide than with any of the analogs. There was no significant difference in either parameter with the different prostaglandin analogs, regardless of the order in which they were evaluated, or even if a month on brinzolamide was intercalated between the analogs.

Conclusions

Brinzolamide was less effective than prostaglandin analogs in reducing 24-h mean IOP and its fluctuations. Switching analogs had no significant effect on mean IOP or mean IOP fluctuations.

Keywords:
Glaucoma
Prostaglandin analogs
Intraocular pressure
Brinzolamide
Latanoprost
Travoprost
Bimatoprost
Resumen
Objetivos

Evaluar la eficacia de la rotación de análogos de prostaglandinas sobre las fluctuaciones de la presión intraocular (PIO) en 24h.

Métodos

Se evaluó a 14 pacientes con glaucoma primario de ángulo abierto mediante curvas mensuales de presión intraocular de 24h, realizando un patrón de cambios mensuales del tratamiento hipotensor entre brinzolamida y análogos de prostaglandinas durante un período de tres años.

Resultados

Tanto el promedio de PIO como el promedio de variación (diferencia entre el pico y el valle) durante las curvas fueron significativamente mayores con la brinzolamida que con cualquiera de los tres análogos. Tanto el promedio de PIO como el promedio de fluctuaciones fueron similares entre los tres análogos, independiente del orden en que se usaron o de si se intercaló un mes de brinzolamida entre uno y otro análogo.

Conclusiones

La brinzolamida fue menos efectiva para reducir la PIO promedio y sus fluctuaciones durante 24h. No hubo un cambio significativo al rotar los análogos.

Palabras clave:
Glaucoma
Análogos de prostaglandinas
Presión intraocular
Brinzolamida
Latanoprost
Travoprost
Bimatoprost

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