metricas
covid
Buscar en
Cirugía Española (English Edition)
Toda la web
Inicio Cirugía Española (English Edition) Management of anastomotic stenosis after ileocecal resection in Crohn’s diseas...
Información de la revista
Vol. 99. Núm. 8.
Páginas 615-617 (octubre 2021)
Vol. 99. Núm. 8.
Páginas 615-617 (octubre 2021)
Scientific letter
Acceso a texto completo
Management of anastomotic stenosis after ileocecal resection in Crohn’s disease with stenotic pattern surgery vs. endoscopic dilation. Surgery vs. endoscopic dilation
Manejo de la estenosis anastomótica tras una resección ileocecal en la enfermedad de Crohn con patrón estenótico. Cirugía vs. dilatación endoscópica
Visitas
796
Luz Divina Juez Sáez
Autor para correspondencia
luz.juez@gmail.com

Corresponding author.
, Juan Ocaña, Diego Ramos, Javier Die, Juan Carlos García Pérez
Servicio de Cirugía General y del Aparato Digestivo, Hospital Universitario Ramón y Cajal, Madrid, Spain
Este artículo ha recibido
Información del artículo
Texto completo
Bibliografía
Descargar PDF
Estadísticas
Figuras (1)
Tablas (1)
Table 1. Characteristics of the sample.
Texto completo

Crohn’s disease (CD) is histologically characterized as having transmural and patchy involvement of the entire intestinal tract.1 Ileal and ileocolic involvement (L1 and L3 of the Montreal classification, respectively) are the most frequent locations of the disease.2 Currently, and despite the advent of biological treatments, more than half of patients with CD undergo surgery within 10 years of diagnosis. Usually, and although surgery resolves the condition, it is not curative and new procedures are frequently needed due to stenosis in previous anastomoses or new outbreaks of the disease. Within 10 years of an initial intervention, 35% of patients will need some type of reoperation.3

Endoscopic dilation has demonstrated efficacy in the treatment of stricture, both in primary (novo) stenosis and in short-term anastomotic stenosis.4,5 However, the long-term results are controversial.6,7

Our main objective was to evaluate the clinical results of the treatment of anastomotic stenosis of CD with a stenotic pattern using either surgery or endoscopic dilation, and we have conducted a retrospective analytical study from 1990 to 2019 at a tertiary hospital.

Clinical anastomotic stricture was defined as stenosis that required another procedure, either endoscopic or surgical.

The inclusion criteria were: diagnosis of CD with at least a stenotic pattern, age over 18 years, previous ileocecal resection due to stenosis, and having undergone endoscopic or surgical treatment of the anastomosis due to clinical recurrence.

Patients under 18 years of age, those without a follow-up, resections other than ileocecal resection, and strictureplasties were excluded. Likewise, procedures for causes other than stenosis were omitted.

A total of 35 procedures were analyzed, including 21 (60%) endoscopic dilations and 14 (40%) surgical procedures, in 19 patients. The indication of the procedures was determined by a multidisciplinary committee that included gastroenterologists and surgeons.

The median follow-up of the sample was 10.8 years (5–25). The median age was 48.8 (40–52) years, with no differences between groups (P = 0.241). 89% of the patients were ASA II. Four patients were considered ASA III, all of them in the surgical group.

The Montreal classification refers to the phenotype of the disease at diagnosis. Most of the patients were grouped between L1 and L3 (L1 [4 dilation vs 6 surgery]; L3 [7 dilation vs 7 surgery]).

The distribution of the theoretical phenotypes was quite homogeneous. This result is in line with the current concept that the chronic and progressive nature of intestinal damage in CD is manifested as several different complications, such as stricture, fistulae and abscesses.8 The remaining sociodemographic and clinical characteristics are summarized in Table 1.

Table 1.

Characteristics of the sample.

  Total  Dilation  Surgery  P 
  n = 35  n = 21  n = 14   
Age (yrs)  48.8 (41−52)  43.2 (41−51)  50 (38−56)  0.241 
Sex        0.006 
Male  10 (29)  2 (67)  8 (57)   
Female  25 (71)  19 (33)  6 (43)   
ASA        0.019 
II  31 (89)  21 (100)  10 (71)   
III  4 (11)  –  4 (29)   
Montreal        0.114 
L1  10 (29)  4 (19)  6 (43)   
L2  –  –  –   
L3  24 (69)  17 (81)  7 (50)   
L1 + L4  1 (2)  –  1 (7)   
L2 + L4  –  –  –   
L3 + L4  –  –  –   
Behavior        0.007 
Stenosing  13 (37)  4 (19)  9 (64)   
Stenosing + inflammatory  8 (23)  8 (38)  –   
Stenosing + fistulizing  14 (20)  9 (43)  5 (36)   
Smoker at diagnosis  15 (43)  6 (29)  9 (64)  0.080 
Perianal disease  9 (27)  3 (16)  6 (53)  0.122 
Patients  21  14   
Median procedures/person  0.006 

Out of the total of 19 patients analyzed, surgery was selected as the initial procedure for 14 patients, and the surgical option resolved the condition in 12 patients. The other 2 patients required one dilation per patient to resolve the condition. Out of the 5 patients whose initial treatment was dilation, none required salvage surgery.

The median number of procedures in the surgical group was 1 (1–1). This datum contrasts with endoscopic dilations, where the median number of procedures per person was 2 (1–7). This difference is statistically significant (P = 0.006). However, although the patients required more procedures in the endoscopic group, in our sample none required salvage surgery during follow-up.

The mean length of the stenosis was 4.6 ± 0.7 cm.

The median disease-free time until a new procedure was needed was 8.25 years (2.9–16.2) in the surgical group compared to 0.9 years (0.4–2) in the endoscopic dilation group (Log Rank P = 0.000; HR 0.041; 95%CI 0.005–0.329) (Fig. 1).

Fig. 1.

Long-term results of surgery vs endoscopic dilation using the Kaplan–Meier method.

(0.1MB).

One year after surgery, the 14 patients (100%) remained asymptomatic; meanwhile, the first year after dilation, 52% of the patients required another procedure. After 12 years, 83% of surgical patients had not required additional treatment; in the endoscopic group, all patients had undergone more therapeutic sessions.

Seven of the surgical patients (47%) presented complications, which were 85% Clavien-Dindo I and II. In one patient, a ureter was injured during surgery, requiring placement of a double J catheter with subsequent reoperation for removal. In the endoscopic procedures, no major complications (perforation or bleeding) were reported.

As the main limitation, the mean length of the stenosis demonstrated as a prognostic factor for success slightly exceeded the recommendations of previous series.7

Until now, few series have evaluated the outcome of endoscopic dilation for recurrent anastomotic stricture in CD. Our results suggest that surgery achieves a higher success rate with a single procedure than endoscopic dilation, but the tradeoff is a greater number of complications. For this reason, and in addition to the patient’s preferences, the decision on the treatment of ileocecal anastomotic stenosis in CD should be made within a multidisciplinary committee.

Conflict of interests

The authors have no conflict of interests to declare.

References
[1]
R. Kalla, N.T. Ventham, J. Satsangi, I.D.R. Arnott.
Crohn’s disease.
BMJ., 349 (2014), pp. 1-11
[2]
M.S. Silverberg, J. Satsangi, T. Ahmad, I.D.R. Arnott, C.N. Bernstein, S.R. Brant, et al.
Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: report of a Working Party of the 2005 Montreal World Congress of Gastroenterology.
Can J Gastroenterol., 19 (2005), pp. 5A-36A
[3]
G.R. Lichtenstein, E.V. Loftus, K.L. Isaacs, M.D. Regueiro, L.B. Gerson, B.E. Sands.
ACG clinical guideline: management of Crohn’s disease in adults.
Am J Gastroenterol., 113 (2018), pp. 481-517
[4]
L. Lian, L. Stocchi, F.H. Remzi, B. Shen.
Comparison of endoscopic dilation vs surgery for anastomotic stricture in patients with Crohn’s disease following ileocolonic resection.
Clini Gastroenterol Hepatol., 15 (2017), pp. 1226-1231
[5]
K. Endo, S. Takahashi, H. Shiga, Y. Kakuta, Y. Kinouchi, T. Shimosegawa.
Short and long-term outcomes of endoscopic balloon dilatation for Crohn’s disease strictures.
World J Gastroenterol., 19 (2013), pp. 86-91
[6]
Y. Li, L. Stocchi, B. Shen, X. Liu, F.H. Remzi.
Salvage surgery after failure of endoscopic balloon dilatation versus surgery first for ileocolonic anastomotic stricture due to recurrent Crohn’s disease.
Br J Surg., 102 (2015), pp. 1418-1425
[7]
L. Lian, L. Stocchi, B. Shen, X. Liu, J. Ma, B. Zhang, et al.
Prediction of need for surgery after endoscopic balloon dilation of ileocolic anastomotic stricture in patients with Crohn’s disease.
Dis Colon and Rectum., 58 (2015), pp. 423-430
[8]
F. Rieder, E.M. Zimmermann, F.H. Remzi, W.J. Sandborn.
Crohn’s disease complicated by strictures: a systematic review.
Gut., 62 (2013), pp. 1072-1084

Please cite this article as: Juez Sáez LD, Ocaña J, Ramos D, Die J, García Pérez JC. Manejo de la estenosis anastomótica tras una resección ileocecal en la enfermedad de Crohn con patrón estenótico. Cirugía vs. dilatación endoscópica. Cir Esp. 2020. https://doi.org/10.1016/j.ciresp.2020.08.001

Copyright © 2020. AEC
Descargar PDF
Opciones de artículo
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos