metricas
covid
Buscar en
Cirugía Española
Toda la web
Inicio Cirugía Española Arterialización de la vena porta en el trasplante hepático humano
Journal Information
Vol. 72. Issue 3.
Pages 169-174 (September 2002)
Share
Share
Download PDF
More article options
Vol. 72. Issue 3.
Pages 169-174 (September 2002)
Full text access
Arterialización de la vena porta en el trasplante hepático humano
Arterialization of the portal vein in human liver transplantation
Visits
9525
Ramón Charco1
Corresponding author
rcharco@clinic.ub.es

Correspondencia: Dr. R. Charco. Institut de Malalties Digestives. Hospital Clínic. Villarroel, 170. 08036 Barcelona.
, Enrique Murio, José Luis Lázaro, Itxarone Bilbao, Ernest Hidalgo
Adjunto de Cirugía.
Lluís Castellsc, Ricardo Chávezb, Ida Parisib, Carlos Margarita
a Jefe Sección Cirugía
b Cirujano becario.
c Adjunto de Hepatología. Unidad de Trasplante Hepático. Hospital General Universitario Vall d’Hebron. Barcelona.
This item has received
Article information
Resumen

Existen pocos casos publicados de arterialización de la vena porta en el trasplante hepático ortotópico o heterotópico.

Objetivo

Evaluar el efecto de la arterialización de la vena porta en la hemodinámica hepática y la evolución clínica de tres pacientes sometidos a trasplante hepático.

Métodos

Dos pacientes que presentaban trombosis de todo el eje mesentérico-portal recibieron un trasplante hepático ortotópico, y uno con hepatitis fulminante recibió un trasplante auxiliar heterotópico. En todos los casos se efectuó una arterialización de la vena porta.

Resultados

Un paciente falleció 4 meses después de la arterialización portal. Los otros dos permanecen vivos. El injerto auxiliar fue retirado a los tres meses por una completa regeneración del hígado nativo. La función hepática inmediata fue excelente en todos los casos. Sólo un paciente, a los 14 meses, desarrolló encefalopatía y hemorragia por varices esofágicas secundaria a hipertensión portal causada por la fístula arterioportal. Ésta se embolizó con éxito a través de radiología intervencionista. Los datos hemodinámicos demostraron la ausencia de hipertensión portal intrahepática.

Conclusión

El trasplante hepático con arterialización de la vena porta es una alternativa quirúrgica aceptable en los casos de flujo portal insuficiente. La doble circulación arterial no condiciona cambios hemodinámicos.

Palabras clave:
Arterialización de la vena porta
Trasplante hepático humano
Introduction

There are few published cases of arterialization of the portal vein in orthotropic or heterotopic liver transplantation.

Objective

To assess the effect of arterialization of the portal vein on liver hemodynamics and the clinical outcome of three patients undergoing liver transplantation.

Methods

Two patients who presented thrombosis of the entire mesenteric-portal axis underwent orthotopic liver transplantation and one patient with fulminant hepatitis underwent auxiliary heterotopic transplantation. In all patients, arterialization of the portal vein was performed.

Results

One patient died four months after portal arterialization. The remaining two survived. The auxiliary graft was removed three months after the operation due to complete regeneration of the native liver. In all patients, immediate liver function was excellent. Only one patient developed encephalopathy and bleeding due to esophageal varices secondary to portal hypertension caused by an arterial-portal fistula at 14 months. This was successfully embolized by interventionist radiology. Hemodynamic data showed the absence of intrahepatic portal hypertension.

Conclusion

Liver transplantation with arterialization of the portal vein is an acceptable surgical alternative in cases of insufficient portal flow. The double arterial circulation does not affect hemodynamic changes.

Key words:
Arterialization of the vena porta
Human liver transplantation
Full text is only aviable in PDF
Bibliografía
[1.]
A.C. Stieber, G. Zetti, S. Todo, A.G. Tzakis, J.J. Fung, I. Marino, et al.
The spectrum of portal vein thrombosis in liver transplantation.
Ann Surg, 213 (1991), pp. 199-206
[2.]
González E. Moreno, García I. García, Sanz R. Gómez, I. González-Pinto, Segurola C. Loinaz, Romero C. Jiménez.
Liver transplantation in patients with thrombosis of the portal, splenic or superior mesenteric vein.
Br J Surg, 80 (1993), pp. 81-85
[3.]
A. Tzakis, P. Kirkegaard, A. Pinna, E. Jovine, E.P. Misiakos, A. Maziotti, et al.
Liver transplantation with cavoportal hemitransposition in the presence of diffuse portal vein thrombosis.
Transplantation, 65 (1998), pp. 619-624
[4.]
J. Erhard, R. Lange, R. Giebler, R. Giebler, U. Raunen, H. De Groot, et al.
Arterialization of the portal vein in orthotopic and auxiliary liver transplantation.
Transplantation, 27 (1995), pp. 877-879
[5.]
J. Erhard, R. Lange, U. Raunen, R. Scherer, J. Friedrich, M. Pietsch, et al.
Auxiliary liver transplantation with arterialization of the portal vein for acute hepatic failure.
Transplant Int, 11 (1998), pp. 266-271
[6.]
M. Yamaguchi, H. Higashiyama, K. Kumada, R. Okamoto, J. Ueda, Y. Shimahara, et al.
Evaluation of temporary portal vein arterialization: the minimum arterialization blood flow for maintaining liver viability.
Transplant Int, 3 (1990), pp. 162-166
[7.]
P. Neuhaus, W.O. Bechstein, G. Blumhardt, R. Steffen.
Management of portal venous thrombosis in hepatic transplant recipients.
Surg Gynecol Obstet, 171 (1990), pp. 251-252
[8.]
C. Margarit, J.L. Lázaro, R. Charco, E. Hidalgo, Revhaug, E. Murio.
Liver transplantation in patients with splenorenal shunts: intraoperative flow measurements to indicate shunt occlusion.
Liver Transplant Surg, 5 (1999), pp. 35-39
[9.]
G.D. Zuidema, W.D. Gaisford, M.R. Abell, T.M. Brody, S.A. Neill, C.G. Child.
Segmental portal arterialization of the canine liver.
Surgery, 53 (1963), pp. 689-698
[10.]
T.E. Starzl, K.A. Porter, N. Kashiwagi, C.W. Putnam.
Portal hepatotrophic factors, diabetes mellitus and acute liver atrophy, hypertrophy and regeneration.
Surg Gynecol Obstet, 141 (1975), pp. 843-858
[11.]
T.K. Neelamekan, J.G. Geoghegan, M. Curry, J.E. Hegarty, O. Traynor, G.P. McEntee.
Delayed correction of portal hypertension after portal vein conduit arterialization in liver transplantation.
Transplantation, 63 (1997), pp. 1029-1030
[12.]
C. Margarit, J.L. Lázaro, R. Charco, E. Hidalgo, A. Mora, I. Bilbao, et al.
Diminished portal and total hepatic blood flows after liver graft revascularization predicts severity of ischemic lesion.
Transplant Proc, 31 (1999), pp. 444
[13.]
W. Nolte, J. Wiltfang, C.G. Schindler, K. Unterberg, M. Finkenstaedt, P.D. Niedmann, et al.
Bright basal ganglia in T1-weighted magnetic resonance images are frequent in patients with portal vein thrombosis without liver cirrhosis and suggestive of hepatic encephalopathy.
J Hepatol, 29 (1998), pp. 443-449
[14.]
R. Troisi, I. Kerremans, E. Mortier, L. Defreyne, U.J. Hesse, B. De Hemptinne.
Arterialization of the portal vein in pediatric liver transplantation. A report of two cases.
Transplant Int, 11 (1998), pp. 147-151

Artículo publicado en American Journal of Transplantation (Charco R, Margarit C, López-Talavera JC, Hidalgo E, Castells L, Allende H, Segarra A, Moreiras M, Bilbao I. Outcome and hepatic hemodynamics in liver transplant patients with portal vein arterialization. Am J Transplant 2001;1:146-51).

Copyright © 2002. Asociación Española de Cirujanos
Download PDF
Article options
es en pt

¿Es usted profesional sanitario apto para prescribir o dispensar medicamentos?

Are you a health professional able to prescribe or dispense drugs?

Você é um profissional de saúde habilitado a prescrever ou dispensar medicamentos