Protocolization of multicenter clinical studies in the digital era. Is useful data centralization by a data-manager? Antonio Ríos; José Antonio Puñal-Rodríguez; Pablo Moreno; Enrique Mercader-Cidoncha; Eduardo Ferrero-Herrero; Manuel Durán; Guadalupe Ruiz-Merino; José Ruiz-Pardo; José Manuel Rodríguez; Pedro Ramón Gutiérrez;