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Inicio Cirugía Española (English Edition) Chemical embolisation before laparoscopic hepatic resection in early hepatocellu...
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Vol. 86. Issue 5.
Pages 303-307 (October 2009)
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Vol. 86. Issue 5.
Pages 303-307 (October 2009)
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Chemical embolisation before laparoscopic hepatic resection in early hepatocellular carcinoma in cirrhotic patients
Quimioembolización previa a la resección hepática laparoscópica en el carcinoma hepatocelular precoz en pacientes cirróticos
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Ricardo Roblesa,
Corresponding author
rirocam@um.es

Corresponding author.
, Caridad Marína, Asunción López-Conesaa, Antonio Capelc, Pascual Parrillab
a Unidad de Cirugía Hepática y Trasplante Hepático, Departamento de Cirugía, Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain
b Departamento de Cirugía, Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain
c Departamento de Radiología, Hospital Universitario Virgen de la Arrixaca, El Palmar, Murcia, Spain
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Article information
Abstract
Objective

To assess whether preoperative transarterial chemoembolisation (TACE) reduces haemorrhage during laparoscopic resection, thus making the Pringle manoeuvre unnecessary and avoiding any subsequent complications.

Patients and methods

We present 3 cirrhotic Child A patients with early hepatocellular carcinoma, all of whom had been given the same treatment involving resection by laparoscopy and preoperative TACE of the segments to remove. All the nodules were located in the right hepatic lobe. One case was treated using total laparoscopic surgery and the two remaining cases were converted to the hand-assisted technique. In the first case we carried out bisegmentectomy VI–VII; in the second, segmentectomy VI plus radiofrequency of a second nodule in segment VII, and in the third case, segmentectomy V.

Results

There was no morbidity or mortality. Blood transfusion was not required by any of the patients; in fact blood losses were 100, 50, and 150mL, respectively, and it was not necessary to carry out the Pringle manoeuvre. Surgical margin was greater than 1cm in the three cases and hospital stay was less than 3, 3 and 4 days, respectively.

Conclusion

TACE prior to early hepatocellular carcinoma resection in cirrhotic patients seems to improve surgical safety with low blood losses without the use of the Pringle manoeuvre. Prospective random studies should be carried out on a larger number of patients in order to assess this technique.

Keywords:
Laparoscopic liver resection
Preoperative transarterial
chemoembolisation
Hepatocellular carcinoma
Cirrhosis
Resumen

La resección hepática por laparoscopia del hepatocarcinoma sobre cirrosis podría asociarse a un mayor riesgo de hemorragia y a un mayor uso de la maniobra de Pringle que cuando se realiza por vía abierta.

Objetivo

Valorar si la quimioembolización intraarterial preoperatoria (QMEP) reduce la hemorragia durante la resección laparoscópica y se evita así el empleo de la maniobra de Pringle y sus posibles complicaciones.

Pacientes y métodos

Se presentan 3 pacientes con cirrosis Child A con carcinoma hepatocelular (CHC) precoz, a los que se practicó QMEP de los segmentos por resecar. Todos los nódulos se localizaron en el lóbulo hepático derecho. Un caso fue intervenido por cirugía totalmente laparoscópica y los 2 restantes se convirtieron a cirugía laparoscópica asistida con la mano. En un caso se realizó bisegmentectomía VI–VII, en otro se realizó segmentectomía VI más radiofrecuencia de un segundo nódulo en segmento VII, y en el otro caso se realizó segmentectomía V.

Resultados

No hubo morbimortalidad. No se transfundió ningún paciente, las pérdidas hemáticas fueron de 100, 50 y 150ml, respectivamente, y no fue necesaria la maniobra de Pringle. La resección se completó en los 3 casos con un margen superior a 1cm y la estancia hospitalaria fue de 3, 3 y 4 días, respectivamente.

Conclusión

La QMEP permite realizar la resección laparoscópica del CHC sobre cirrosis con pocas pérdidas hemáticas sin el uso de la maniobra de Pringle. Estudios prospectivos aleatorizados son necesarios con un mayor número de pacientes para evaluar esta técnica.

Palabras clave:
Resección hepática laparoscópica
Embolización transarterial
preoperatoria
Hepatocarcinoma
Cirrosis
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References
[1.]
D. Cherqui, A. Laurent, C. Tayar, S. Chang, J.T. van Nhieu, J. Loriau, et al.
Laparoscopic liver resection for peripheral hepatocellular carcinoma in patients with chronic liver disease: Midterm results and perspectives.
[2.]
G. Belli, C. Fantini, A. d’Agostino, A. Belli, N. Rusolillo, L. Cioffi.
Laparoscopic liver resection without a Pringle maneuver for HCC in cirrhotic patients.
Chir Ital, 57 (2005), pp. 15-25
[3.]
G. Belli, C. Fantini, A. d’Agostino, A. Belli, N. Russolillo.
Laparoscopic vs open liver resection for hepatocellular carcinoma in patients with histologically proven cirrhosis: Short- and middle-term results.
Surg Endosc, 21 (2007), pp. 2004-2011
[4.]
J.L. Dulucq, P. Wintringer, C. Stabilini, J. Berticelli, A. Mahajna.
Laparoscopic liver resections: A single center experience.
Surg Endosc, 19 (2005), pp. 886-891
[5.]
B. Gayet, D. Cavaliere, E. Vibert, T. Perniceni, H. Levard, C. Denet, et al.
Totally laparoscopic right hepatectomy.
Am J Surg, 194 (2007), pp. 685-689
[6.]
I. Dagher, J.M. Proske, A. Carloni, H. Richa, H. Tranchart, D. Franco.
Laparoscopic liver resection: Results for 70 patients.
Surg Endosc, 21 (2007), pp. 619-624
[7.]
E. Vibert, T. Perniceni, H. Levard, C. Denet, N.K. Shahri, B. Gayet.
Laparoscopic liver resection.
Ann Surg, 93 (2006), pp. 67-72
[8.]
H. Kaneko, S. Takagi, Y. Otsuka, M. Tsuchiya, A. Tamura, T. Katagiri, et al.
Laparoscopic liver resection of hepatocellular carcinoma.
Am J Surg, 189 (2005), pp. 190-194
[9.]
K. Teramoto, T. Kawamura, S. Takamatsu, N. Nakaumura, A. Kudo, N. Noguchi.
Laparoscopic and thoracoscopic approaches for the treatment of hepatocellular carcinoma.
Am J Surg, 189 (2005), pp. 474-478
[10.]
C.D. Lu, S.Y. Peng, X.C. Jiang, Y. Chiba, N.L. Tanigawa.
Preoperative transcatheter arterial chemoembolization and prognosis of patients with hepatocellular carcinomas: Retrospective analysis of 120 cases.
World J Surg, 23 (1999), pp. 293-300
[11.]
G.H. Choi, D.H. Kim, C.M. Kang, K.S. Kim, J.S. Choi, W.J. Lee, et al.
Is preoperative transarterial chemoembolization needed for a resectable hepatocellular carcinoma?.
Worl J Surg, 31 (2007), pp. 2370-2377
[12.]
X.P. Chen, D.Y. Hu, Y.F. Zhang, W.G. Zhang, F.Z. Qiu.
Role of mesohepatectomy with or without transcatheter arterial chemoembolization for large centrally hepatocellular carcinoma.
Dig Surg, 24 (2007), pp. 208-213
[13.]
J.M. Llovet, J. Fuster, J. Bruix.
Barcelona-Clinic Liver Cancer Group: Diagnosis, staging, and treatment of hepatocellular carcinoma.
Liver Tranpl, 10 (2004), pp. S115-S120
[14.]
C.M. Lo, H. Ngan, W.K. Tso, C.L. Liu, C.M. Lam, R.T. Poon, et al.
Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma.
Hepatology, 35 (2002), pp. 1164-1171
[15.]
T.D. Kirchhoff, J.S. Bleck, A. Dettmer, A. Chavan, H. Rosenthal, S. Merkesdal, et al.
Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: Evaluation of tumor response, toxicity, and survival.
Hepatobiliary Pancreat Dis Int, 6 (2007), pp. 259-266
[16.]
R. Robles, B. Abellán, C. Marín, J.A. Fernández, P. Ramírez, D. Morales, et al.
Laparoscopic resection of solid liver tumors Presentation of our experience.
Cir Esp, 78 (2005), pp. 238-245
[17.]
R. Robles, C. Marín, B. Abellán, A. López Conesa, P. Pastor, P. Parrilla.
A new approach to hand-assisted laparoscopic liver surgery.
Surg Endosc, 22 (2008), pp. 2357-2364
[18.]
A.J. Koffron, G. Auffenberg, R. Kung, M. Abecassis.
Evaluation of 300 minimally invasive liver resections at a single institution Less is more.
Ann Surg, 246 (2007), pp. 385-394
[19.]
J.F. Buell, M.T. Thomas, S. Rudich, M. Marvin, R. Nagubandi, K.V. Ravindra, et al.
Experience with more than 500 minimally invasive hepatic procedures.
Ann Surg, 248 (2008), pp. 475-486
Copyright © 2009. Asociación Española de Cirujanos
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