Thoracic aortic size in Brazilian smokers: measures using low-dose chest computed tomography anatomical and epidemiological assessment

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Thoracic aortic aneurysms (TAAs) represent one-third of the hospitalizations for aortic diseases (<a class="elsevierStyleCrossRef" href="#bib1">1</a>). TAAs are classified according to their anatomical location: ascending aorta aneurysms (most common), aortic arch aneurysms, descending TAAs, and thoracoabdominal aneurysms (<a class="elsevierStyleCrossRef" href="#bib2">2</a>).TAAs and infrarenal abdominal aortic aneurysms share the same risk factors: smoking, systemic hypertension, and dyslipidemia (<a class="elsevierStyleCrossRef" href="#bib3">3</a>). TAAs are often asymptomatic, which hinders their diagnosis, present slow growth, are strongly related to congenital and degenerative diseases (<a class="elsevierStyleCrossRef" href="#bib4">4</a>), and can cause severe complications such as upper limb ischemia, carotid and vertebral embolization, and, the most feared of all, rupture.The surgical treatment of aneurysms aims to reduce the risk of these complications and to treat symptoms, when they exist, to avoid rupture. However, surgical treatment is not risk-free (<a class="elsevierStyleCrossRef" href="#bib5">5</a>,<a class="elsevierStyleCrossRef" href="#bib6">6</a>). Thus, it is only recommended when the maximum diameter of the aneurysm, in the descending thoracic aorta, is greater than 6 cm (<a class="elsevierStyleCrossRef" href="#bib7">7</a>). Above these diameters, the risks of surgery are lower than the risk of rupture, justifying treatment.Several studies have sought to identify the actual incidence of TAAs; however, the incidence rate depends on the definition of the normal size of the aorta, which is quite variable, depending on the population studied. Hence, it is important to first determine the characteristics of a normal population to evaluate the incidence of TAAs. Recently, two studies were conducted to analyze the average size of all segments of the thoracic aorta using chest computed tomography (CT) in patients without risk factors for TAAs and thus evaluate the prevalence of TAAs in these populations (<a class="elsevierStyleCrossRef" href="#bib8">8</a>,<a class="elsevierStyleCrossRef" href="#bib9">9</a>). Itani et al., in Japan, in 2002 (<a class="elsevierStyleCrossRef" href="#bib8">8</a>), used the population's standard deviation (SD) to define an abnormality value; values above three SDs were considered abnormal. Thus, they found a prevalence of 0.16%. Kälsch et al., in 2013, in Germany, defined any dilatation of the thoracic aorta with a diameter greater than 5 cm as a TAA, resulting in a prevalence of 0.34% (<a class="elsevierStyleCrossRef" href="#bib9">9</a>).In Brazil, this type of study has not yet been performed and is relevant both internally to demonstrate the local anatomical conditions and to the rest of the world to demonstrate the difference in relation to other countries and the possible need for individualized population studies.The aim of this study was to evaluate the characteristics of the thoracic aorta of Brazilian smokers, identifying the normal size of the aorta, presence of anatomical variations in the supra-aortic trunks, and prevalence of TAAs.MATERIALS AND METHODSA total of 711 volunteers aged between 55 and 74 years, smokers (tobacco use 30 packs/year or more), and without signs or symptoms of aortic diseases were studied. All patients underwent radiological evaluation with low-dose CT from January 2013 to July 2014 with the initial objective of lung nodule tracking. Some of them were followed up, but at this moment, we analyzed only the first images. The anthropometric characteristics are presented in <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>. The included patients were in the sixth decade of life and had mild overweight and a similar distribution between sexes, with an average body surface area (BSA) of 1.83 m2.<elsevierMultimedia ident="tbl1"></elsevierMultimedia>The tests were performed using a single device (Toshiba Aquilion 64 CFX CT, Toshiba Medical Systems Corporation, Otawara, Tochigi, Japan) and a low radiation dose technique (120 kV and a maximum of 15 mA with a 1×1 mm collimation). The images were stored in a Picture Archiving and Communication System (PACS) in the Digital Imaging and Communications in Medicine (DICOM) format.These images were evaluated by two examiners, and measurements were performed manually using Horos version 3.2.0 (Horos Project, Geneva, Switzerland). At each segment, diameter measurements were taken of the thoracic aorta (ascending aorta, aortic arch, and descending aorta) in true orthogonal planes, corrected by the central axis, by a single examiner.Then, serial measurements were made at precisely defined points. In the ascending aorta, diameter measurements were taken every 2 cm with the origin immediately proximal to the brachiocephalic trunk. In the descending aorta, serial measurements were performed every 5 cm with the origin immediately distal to the origin of the left subclavian artery.The most frequent anatomical variations were evaluated: the presence of a common origin between the right carotid artery and the brachiocephalic trunk (bovine arch) and the presence of an abnormal origin of the left vertebral artery and aberrant left subclavian artery. Aortic arch types were classified as follows: type 1, when the origin of the supra-aortic trunk is found in an imaginary plane above the greater curvature of the aorta; type 2, when one of the vessels originates in a plane between the greater and lesser curvature of the aorta; and type 3, when one of the vessels originates proximal to the plane drawn in the lesser curvature of the aorta (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>). In addition, anatomical characteristics were correlated with anthropometric characteristics, body mass index (BMI), and BSA.<elsevierMultimedia ident="fig1"></elsevierMultimedia>To identify the importance of each variable in determining the diameter value for each segment, we performed multiple linear regression with the following parameters: sex, age, and average BSA. Based on this analysis, we obtained the expected measures for each segment, stratified by sex and age group.This study was approved by the institution's ethics committee and exempt from informed consent.RESULTSFor each patient, we performed, at least, six measures of aortic diameters: two in the ascending segment, one in the aortic arch, and three in the descending aorta. This resulted in 4,266 diameter measurement points and a total of 8,532 measurements.The maximum diameters of each segment are shown in <a class="elsevierStyleCrossRef" href="#fig2">Figure 2</a>. The largest arterial diameter was observed in the ascending segment, at 33.61 mm (SD, 3.88). In the aortic arch and the descending aorta, we found smaller diameters (28.66 mm [SD 2.89] and 28.36 [SD 3.09], respectively).<elsevierMultimedia ident="fig2"></elsevierMultimedia>Analysis of the correlation between values and anthropometric characteristics showed a positive correlation between male sex, age, and BSA with aorta diameter, with a stronger correlation for BSA and the descending aorta (<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>).<elsevierMultimedia ident="tbl2"></elsevierMultimedia>Multiple linear regressions confirmed that age, BSA, and male sex were good predictors of aortic size in the descending segment, as shown in <a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a>. The equations used to calculate the diameter of each segment are shown in <a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a>, and the expected aortic diameters for each segment are represented in <a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>.<elsevierMultimedia ident="tbl3"></elsevierMultimedia><elsevierMultimedia ident="tbl4"></elsevierMultimedia><elsevierMultimedia ident="fig3"></elsevierMultimedia>Anatomical variations were observed in 81 (11.4%) patients, and the bovine arch was the most common variation. Among the aortic arch types, type 1 was the most common (<a class="elsevierStyleCrossRef" href="#tbl5">Table 5</a>).<elsevierMultimedia ident="tbl5"></elsevierMultimedia>Finally, we found only one (0.14%) aneurysm in the descending aorta.DISCUSSIONTAA is a silent disease of increasing incidence and high morbidity and mortality, the prognosis of which depends substantially on the size of the aorta in each segment. In the past, analyses of normal vessel dimensions were performed based on angiography, ultrasound (<a class="elsevierStyleCrossRef" href="#bib10">10</a>), and magnetic resonance imaging (<a class="elsevierStyleCrossRef" href="#bib11">11</a>). With the increased availability of tomography, studies to identify the anatomical features of the aorta have been performed. In recent years, several studies have been conducted with this aim in North America (<a class="elsevierStyleCrossRef" href="#bib2">2</a>,<a class="elsevierStyleCrossRef" href="#bib12">12</a>,<a class="elsevierStyleCrossRef" href="#bib13">13</a>), (<a class="elsevierStyleCrossRef" href="#bib14">14</a>) Europe (<a class="elsevierStyleCrossRef" href="#bib9">9</a>), and the East (<a class="elsevierStyleCrossRef" href="#bib8">8</a>,<a class="elsevierStyleCrossRef" href="#bib15">15</a>). The objective of our study was to analyze the dimensions of the aorta in Brazil and evaluate the impact of BMI, BSA, and age.Currently, there is increasing concern about the deleterious effects of radiation. Thus, the use of tomography exams with low radiation doses, as performed in our study, is gaining importance. Wolak et al. (<a class="elsevierStyleCrossRef" href="#bib12">12</a>) were the first to evaluate, on a large scale, the dimensions of large vessels with the use of tomography without contrast. Their data were comparable to those of a contrasted series and showed a high interobserver correlation. Thus, we can infer that the modern protocols do not require contrast and high doses of radiation to measure aortic diameters.In our study, we used a sample previously selected for the screening of lung diseases (<a class="elsevierStyleCrossRef" href="#bib16">16</a>). Thus, our study included patients in an older age group, similar to two studies conducted in Japan and Korea, which also used samples previously selected for lung neoplasia screening (<a class="elsevierStyleCrossRef" href="#bib8">8</a>,<a class="elsevierStyleCrossRef" href="#bib15">15</a>).The demographic characteristics of our sample were similar to those in a national study that evaluated causes of death in Brazilian patients with aortic aneurysms (<a class="elsevierStyleCrossRef" href="#bib17">17</a>), with no predominance of any sex and with a slightly higher than average age than American (<a class="elsevierStyleCrossRef" href="#bib2">2</a>) and German (<a class="elsevierStyleCrossRef" href="#bib9">9</a>) populations.The maximum diameter of the ascending aorta was similar to that reported for two American series that used patients undergoing coronary disease control exams (<a class="elsevierStyleCrossRef" href="#bib12">12</a>,<a class="elsevierStyleCrossRef" href="#bib18">18</a>) and was lower than that reported for a large population study (<a class="elsevierStyleCrossRef" href="#bib2">2</a>). This difference could be due to selection bias. A review which compared the works of Rogers, Wolak and Mao enrolled younger patients who consequently presented with fewer comorbidities and smaller vessels.When compared with the mean diameter of the ascending aorta in non-American populations, the mean diameter of the ascending aorta in Brazilians was 1 mm greater than that found in Japanese patients (<a class="elsevierStyleCrossRef" href="#bib8">8</a>) (younger patients) and 5 mm smaller than that found in a German population (<a class="elsevierStyleCrossRef" href="#bib9">9</a>).The aortic arch diameter tends to be less evaluated in series because its evaluation demands a more arduous methodology. Even so, we could compare our results with those reported in a study by Hager et al. (<a class="elsevierStyleCrossRef" href="#bib19">19</a>) in German patients, which showed a slightly higher average diameter than that in Brazilians. However, the diameter of the descending aorta was higher than that reported by the majority of series (<a class="elsevierStyleCrossRef" href="#bib8">8</a>,<a class="elsevierStyleCrossRef" href="#bib9">9</a>,<a class="elsevierStyleCrossRef" href="#bib12">12</a>,<a class="elsevierStyleCrossRef" href="#bib15">15</a>), except for the Japanese series (<a class="elsevierStyleCrossRef" href="#bib8">8</a>), which can be explained by the mean age of our patients, which was 60.9 years, compared to other studies with populations younger than 60 years (<a class="elsevierStyleCrossRef" href="#bib9">9</a>,<a class="elsevierStyleCrossRef" href="#bib19">19</a>).Therefore, the diameter of the ascending aorta was smaller in Europeans and larger in Asians, while the diameter of the descending aorta had opposite characteristics.There was a significant difference in measurements between sexes, with larger diameters in men in all segments, based on data previously demonstrated by other studies (<a class="elsevierStyleCrossRef" href="#bib9">9</a>,<a class="elsevierStyleCrossRef" href="#bib12">12</a>) and reaffirmed in our study.The relationship between anthropometric data and vessel dimensions is already known. BMI, age, and BSA were related to the diameter of the thoracic aorta, with correlations similar to European and Asian studies. Thus, we sought to correlate aortic diameters with BMI and mean BSA, which is more accurate than BMI in evaluating the correlation between body measurements and aortic diameters (<a class="elsevierStyleCrossRef" href="#bib20">20</a>).Our patients had a mean BMI of 26.28, which is compatible with Brazilian data, which show a high incidence of overweight status, especially in age groups older than 60 years. The population in our study showed a lower BSA than most studies (<a class="elsevierStyleCrossRef" href="#bib9">9</a>,<a class="elsevierStyleCrossRef" href="#bib12">12</a>,<a class="elsevierStyleCrossRef" href="#bib19">19</a>), with the exception of a Korean study (<a class="elsevierStyleCrossRef" href="#bib15">15</a>). These variations confirm the need for careful evaluation when comparing data from different populations.Keeping in mind that our population has a smaller BSA than others and that there was a correlation between BSA and aortic diameter in three segments (ascending aorta, trunk, and descending aorta), one would expect proportionally smaller diameters compared to those reported in other studies. We think that the high rate of smoking and the consequences of its use on the arterial wall led to an increase in aortic diameter.The diameter is also influenced by age, which showed a significant correlation in all segments, especially in the descending aorta, as observed by Rogers et al. and Itani et al. (<a class="elsevierStyleCrossRef" href="#bib2">2</a>,<a class="elsevierStyleCrossRef" href="#bib8">8</a>). We know that there is a greater concentration of elastic tissue in the thoracic aorta as it approaches the diaphragm. Over time, degeneration of these fibers occurs, which leads to a progressive increase in the vessel by losing its elastic characteristics, becoming less compliant.Because there is considerable phenotypic variation among the populations (Europeans, for example, have greater stature than Eastern populations), we performed multiple linear regression that resulted in a formula to find the expected diameter of each aortic segment as a function of BSA, BMI, and age range.We observed an incidence of anatomical variations in the supra-aortic trunks in 11.4% of the sample. As in other studies (<a class="elsevierStyleCrossRef" href="#bib21">21</a>,<a class="elsevierStyleCrossRef" href="#bib22">22</a>), we found that the most common variation was the bovine arch, present in 9.6% of our sample. Mylonas (<a class="elsevierStyleCrossRef" href="#bib23">23</a>) found an increased risk of aortic diseases in the presence of a bovine trunk; however, we found no relationship between anatomical variation and the presence of aneurysms.Our study has some limitations. We are the first group to accurately assess the anatomical features of the aorta of Brazilians. These analyses were performed in non-contrast low-dose exams, which resulted in lower morbidity. In contrast to other series, which made two measurements in the axial plane (<a class="elsevierStyleCrossRef" href="#bib8">8</a>,<a class="elsevierStyleCrossRef" href="#bib9">9</a>,<a class="elsevierStyleCrossRef" href="#bib12">12</a>,<a class="elsevierStyleCrossRef" href="#bib18">18</a>), we used precisely defined sites in several aortic segments and performed all corrective measurements for the true axis of the vessel, which is the most accurate method (<a class="elsevierStyleCrossRef" href="#bib24">24</a>) and recommended by the guidelines.This resulted in 4,200 evaluated diameters that led us to find, with great accuracy, the real diameter of each segment (ascending aorta, aortic arch, and descending aorta).In addition, the sample had a high prevalence of smokers and elderly individuals, which are factors usually related to larger aortic dimensions. However, they are the most frequent patients with TAAs and are therefore a good indicator of the measurements of patients at risk for developing the disease. In addition, the evaluation of the proximal segment of the aorta close to the sinus, an area of high tissue density that was impaired by the absence of contrast, prevented accurate measurements of the extent of the ascending aorta segment.We believe that with technological evolution, using artificial intelligence and robotic analysis mechanisms, we will be able to evaluate large volumes of CT data and have more significant anatomical data from global populations in the near future.CONCLUSIONSIn elderly Brazilian smokers, who are part of a population at greatest risk for aneurysms, the mean diameters of the ascending aorta, aortic arch, and descending aorta were 33.6 mm, 28.7 mm, and 28.4 mm, respectively.Anatomical variations were observed in 81 (11.4%) patients, with bovine arch being the most common, and TAA prevalence was 0.14%.AUTHOR CONTRIBUTIONSLembrança L, Teivelis MP, Tachibana A, dos Santos RS were responsible for the research, manuscript development, data collection and manuscript writing. Joo RW and Zippo E were responsible for the data collection. Wolosker N was responsible for the manuscript development and approval." "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xpalclavsec1577398" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:2 [ "identificador" => "cesec20" "titulo" => "MATERIALS AND METHODS" ] 3 => array:2 [ "identificador" => "cesec30" "titulo" => "RESULTS" ] 4 => array:2 [ "identificador" => "cesec40" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec50" "titulo" => "CONCLUSIONS" ] 6 => array:2 [ "identificador" => "cesec60" "titulo" => "AUTHOR CONTRIBUTIONS" ] 7 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-08-09" "fechaAceptado" => "2020-11-06" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1577398" "palabras" => array:4 [ 0 => "Aorta" 1 => "Diameter" 2 => "Arch" 3 => "Thoracic" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "OBJECTIVES:Thoracic aortic aneurysms (TAAs) represent one-third of the hospitalizations for aortic diseases. The prevalence rate depends on the definition of the normal size of the aorta, which is quite variable, depending on the population studied. The aim of this study was to evaluate the characteristics of the thoracic aorta of Brazilian smokers, identifying the normal size of the aorta, presence of anatomical variations, and prevalence of TAA. MATERIALS AND METHODS:A total of 711 patients underwent radiological evaluation with low-dose computed tomography (CT) from January 2013 to July 2014 with the initial objective of lung nodule tracking. Two examiners evaluated these images, and measurements of maximum and serial diameters were performed manually in true orthogonal planes. Serial diameter measurements were taken every 2 cm in the ascending aorta and 5 cm in the descending segment. We searched for anatomical variations, aortic arch type, and correlations between anatomical characteristics, sex, body mass index, and body surface area (BSA). RESULTS:The maximum diameters were 33.61 (standard deviation [SD] 3.88), 28.66 (SD 2.89), and 28.36 mm (SD 3.09) for the ascending segment, aortic arch, and descending segment, respectively. A positive correlation was found between male sex, age, and BSA and aorta diameter. The bovine arch was the most common variation of the aortic arch type, and we found one (0.14%) case of TAA. CONCLUSIONS:This study with low-dose CT allowed the determination of the mean diameters of the ascending aorta, aortic arch, and descending aorta in Brazilian smokers and TAA prevalence." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVES:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "MATERIALS AND METHODS:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "RESULTS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "CONCLUSIONS:" ] ] ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "No potential conflict of interest was reported." ] ] "multimedia" => array:8 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 317 "Ancho" => 750 "Tamanyo" => 31333 ] ] "descripcion" => array:1 [ "en" => "Aortic arch classification." ] ] 1 => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 597 "Ancho" => 750 "Tamanyo" => 17852 ] ] "descripcion" => array:1 [ "en" => "Aortic diameters by segment." ] ] 2 => array:7 [ "identificador" => "fig3" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 471 "Ancho" => 750 "Tamanyo" => 21208 ] ] "descripcion" => array:1 [ "en" => "Expected descending aorta diameter for body surface area." ] ] 3 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "SD: standard deviation." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60.9 (4.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Median (Q1; Q3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">60 (57; 64) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Range \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">54-74 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Sex \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">352 (49.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">359 (50.5%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Weight (kg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">73.0 (15.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Median (Q1; Q3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">71 (62; 81) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Range \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">35-131 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Height (cm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">166.4 (9.1) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Median (Q1; Q3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">167 (160; 173) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Range \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">141-193 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Body mass index (kg/m2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">26.3 (4.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Median (Q1; Q3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">25.8 (23.3; 28.7) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Range \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.6-49.8 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Body surface area (m2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Mean (SD) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.83 (0.22) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Median (Q1; Q3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.81 (1.67; 1.97) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Range \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.21-2.55 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Patient characteristics." ] ] 4 => array:7 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "Pearson correlation (p value)." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variables \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Female \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Male \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n=711 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n=359 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n=352 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ascending aorta \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.240 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.259 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.172 (p=0.001) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Aortic arch \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.252 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.157 (p=0,003) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.281 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Descending aorta \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.322 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.190 (p<0,001) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.386 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Body surface area \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n=707 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n=358 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">n=349 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ascending aorta \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.350 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.207 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.263 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Aortic arch \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.376 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.288 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.237 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Descending aorta \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.403 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.286 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.203 (p<0.001) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Correlations between aortic diameter, age, and body surface area." ] ] 5 => array:7 [ "identificador" => "tbl3" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Predictor \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Unstandardized coefficient (standardized) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Standard error \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">p value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.108 (0.166) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.029 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male sex \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">−7.280 (−1.180) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.479 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Body surface index \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.833 (0.272) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.491 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age and male sex \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.149 (1.494) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.040 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Constant \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13.811 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.982 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Predictors of descending aorta diameter." ] ] 6 => array:7 [ "identificador" => "tbl4" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Aortic segment \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Linear regression equation \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Ascending \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Maximum diameter=11.849+0.202 × age+3.583 (for male sex)+4.829 × BSA − 0.038 × age (for male sex) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Arch \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Maximum diameter=15.060+0.095 × age − 4.417 (for male sex)+3.988 × BSA+0.088 × age (for male sex) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Descending \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Maximum diameter=13.811+0.108 × age − 7.280 (for male sex)+3.833 × BSA+0.149 × age (for male sex) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Linear regression equations for each segment." ] ] 7 => array:7 [ "identificador" => "tbl5" "etiqueta" => "Table 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Anatomic variations \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bovine arch \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">69 (9.7%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Abnormal origin of vertebral artery \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">13 (1.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Aberrant right subclavian artery \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (0.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Aortic arch classification \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Type 1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">394 (55.4%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Type 2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">229 (32.2%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Type 3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">88 (12.4%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Anatomic variations." ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:24 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, American Association for Thoracic Surgery, American College of Radiology, American Stroke Association, Society of Cardiovascular Anesthesiologists, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, Society of Thoracic Surgeons, and Society for Vascular Medicine" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ LF Hiratzka \n \t\t\t\t\t\t\t\t """ 1 => """ GL Bakris \n \t\t\t\t\t\t\t\t """ 2 => """ JA Beckman \n \t\t\t\t\t\t\t\t """ 3 => """ RM Bersin \n \t\t\t\t\t\t\t\t """ 4 => """ VF Carr \n \t\t\t\t\t\t\t\t """ 5 => """ DE Casey Jr \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/CIR.0b013e3181d4739e" "Revista" => array:7 [ "tituloSerie" => "Circulation" "fecha" => "2010" "volumen" => "121" "numero" => "13" "paginaInicial" => "e266" "paginaFinal" => "e369" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20233780" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Distribution, determinants, and normal reference values of thoracic and abdominal aortic diameters by computed tomography (from the Framingham Heart Study)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ IS Rogers \n \t\t\t\t\t\t\t\t """ 1 => """ JM Massaro \n \t\t\t\t\t\t\t\t """ 2 => """ QA Truong \n \t\t\t\t\t\t\t\t """ 3 => """ AA Mahabadi \n \t\t\t\t\t\t\t\t """ 4 => """ MF Kriegel \n \t\t\t\t\t\t\t\t """ 5 => """ CS Fox \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Am J Cardiol" "fecha" => "2013" "volumen" => "5" "numero" => "10" "paginaInicial" => "1510" "paginaFinal" => "1516" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.amjcard.2013.01.306" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Are aortic aneurysms caused by atherosclerosis?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ D Reed \n \t\t\t\t\t\t\t\t """ 1 => """ C Reed \n \t\t\t\t\t\t\t\t """ 2 => """ G Stemmermann \n \t\t\t\t\t\t\t\t """ 3 => """ T Hayashi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1161/01.cir.85.1.205" "Revista" => array:7 [ "tituloSerie" => "Circulation" "fecha" => "1992" "volumen" => "85" "numero" => "1" "paginaInicial" => "205" "paginaFinal" => "211" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1728451" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1161/01.cir.85.1.205" "WWW" => array:1 [ "link" => "https://doi.org/10.1161/01.CIR.85.1.205" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Familial thoracic aortic aneurysms and dissections–incidence, modes of inheritance, and phenotypic patterns" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ G Albornoz \n \t\t\t\t\t\t\t\t """ 1 => """ MA Coady \n \t\t\t\t\t\t\t\t """ 2 => """ M Roberts \n \t\t\t\t\t\t\t\t """ 3 => """ RR Davies \n \t\t\t\t\t\t\t\t """ 4 => """ M Tranquilli \n \t\t\t\t\t\t\t\t """ 5 => """ JA Rizzo \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.athoracsur.2006.04.098" "Revista" => array:7 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2006" "volumen" => "82" "numero" => "4" "paginaInicial" => "1400" "paginaFinal" => "1405" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16996941" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.athoracsur.2006.04.098" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.athoracsur.2006.04.098" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Thoracic aortic aneurysm clinically pertinent controversies and uncertainties" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ JA Elefteriades \n \t\t\t\t\t\t\t\t """ 1 => """ EA Farkas \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2009.08.084" "Revista" => array:7 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2010" "volumen" => "55" "numero" => "9" "paginaInicial" => "841" "paginaFinal" => "857" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20185035" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.jacc.2009.08.084" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.jacc.2009.08.084" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increasing incidence of ruptured abdominal aortic aneurysm: a population-based study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ S Acosta \n \t\t\t\t\t\t\t\t """ 1 => """ M Ogren \n \t\t\t\t\t\t\t\t """ 2 => """ H Bengtsson \n \t\t\t\t\t\t\t\t """ 3 => """ D Bergqvist \n \t\t\t\t\t\t\t\t """ 4 => """ B Lindblad \n \t\t\t\t\t\t\t\t """ 5 => """ Z Zdanowski \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.jvs.2006.04.037" "Revista" => array:7 [ "tituloSerie" => "J Vasc Surg" "fecha" => "2006" "volumen" => "44" "numero" => "2" "paginaInicial" => "237" "paginaFinal" => "243" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16890847" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.jvs.2006.04.037" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.jvs.2006.04.037" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expert consensus document on the treatment of descending thoracic aortic disease using endovascular stent-grafts" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ LG Svensson \n \t\t\t\t\t\t\t\t """ 1 => """ NT Kouchoukos \n \t\t\t\t\t\t\t\t """ 2 => """ DC Miller \n \t\t\t\t\t\t\t\t """ 3 => """ JE Bavaria \n \t\t\t\t\t\t\t\t """ 4 => """ JS Coselli \n \t\t\t\t\t\t\t\t """ 5 => """ MA Curi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.athoracsur.2007.10.099" "Revista" => array:7 [ "tituloSerie" => "Ann Thorac Surg" "fecha" => "2008" "volumen" => "85" "numero" => "1 Suppl" "paginaInicial" => "S1" "paginaFinal" => "41" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18083364" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.athoracsur.2007.10.099" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.athoracsur.2007.10.099" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Measurement of aortic diameters and detection of asymptomatic aortic aneurysms in a mass screening program using a mobile helical computed tomography unit" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ Y Itani \n \t\t\t\t\t\t\t\t """ 1 => """ S Watanabe \n \t\t\t\t\t\t\t\t """ 2 => """ Y Masuda \n \t\t\t\t\t\t\t\t """ 3 => """ K Hanamura \n \t\t\t\t\t\t\t\t """ 4 => """ K Asakura \n \t\t\t\t\t\t\t\t """ 5 => """ S Sone \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s380-002-8315-1" "Revista" => array:7 [ "tituloSerie" => "Heart Vessels" "fecha" => "2002" "volumen" => "16" "numero" => "2" "paginaInicial" => "42" "paginaFinal" => "45" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11833840" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s380-002-8315-1" "WWW" => array:1 [ "link" => "https://doi.org/10.1007/s380-002-8315-1" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Body-surface adjusted aortic reference diameters for improved identification of patients with thoracic aortic aneurysms: results from the population-based Heinz Nixdorf Recall study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ H Kälsch \n \t\t\t\t\t\t\t\t """ 1 => """ N Lehmann \n \t\t\t\t\t\t\t\t """ 2 => """ S Möhlenkamp \n \t\t\t\t\t\t\t\t """ 3 => """ A Becker \n \t\t\t\t\t\t\t\t """ 4 => """ S Moebus \n \t\t\t\t\t\t\t\t """ 5 => """ A Schmermund \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.ijcard.2011.05.039" "Revista" => array:7 [ "tituloSerie" => "Int J Cardiol" "fecha" => "2013" "volumen" => "163" "numero" => "1" "paginaInicial" => "72" "paginaFinal" => "78" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21641667" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.ijcard.2011.05.039" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.ijcard.2011.05.039" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Two-dimensional echocardiographic aortic root dimensions in normal children and adults" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ MJ Roman \n \t\t\t\t\t\t\t\t """ 1 => """ RB Devereux \n \t\t\t\t\t\t\t\t """ 2 => """ R Kramer-Fox \n \t\t\t\t\t\t\t\t """ 3 => """ J O’Loughlin \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/0002-9149(89)90430-x" "Revista" => array:7 [ "tituloSerie" => "Am J Cardiol" "fecha" => "1989" "volumen" => "64" "numero" => "8" "paginaInicial" => "507" "paginaFinal" => "512" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2773795" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/0002-9149(89)90430-x" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/0002-9149(89)90430-X" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angio-RM das artérias carótidas e vertebrais: análise de diferentes técnicas de volume e diluição de contraste em aparelho de 1,0 T e gradiente de 15 mT/m*" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ LG Hartmann \n \t\t\t\t\t\t\t\t """ 1 => """ AM Wolosker \n \t\t\t\t\t\t\t\t """ 2 => """ G D’Ippolito \n \t\t\t\t\t\t\t\t """ 3 => """ ML Borri \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Radiol Bras" "fecha" => "2001" "volumen" => "34" "numero" => "4" "paginaInicial" => "201" "paginaFinal" => "205" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1590/S0100-39842001000400005" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aortic size assessment by noncontrast cardiac computed tomography: normal limits by age, gender, and body surface area" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ A Wolak \n \t\t\t\t\t\t\t\t """ 1 => """ H Gransar \n \t\t\t\t\t\t\t\t """ 2 => """ LE Thomson \n \t\t\t\t\t\t\t\t """ 3 => """ JD Friedman \n \t\t\t\t\t\t\t\t """ 4 => """ R Hachamovitch \n \t\t\t\t\t\t\t\t """ 5 => """ A Gutstein \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.jcmg.2007.11.005" "Revista" => array:7 [ "tituloSerie" => "JACC Cardiovasc Imaging" "fecha" => "2008" "volumen" => "1" "numero" => "2" "paginaInicial" => "200" "paginaFinal" => "209" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19356429" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.jcmg.2007.11.005" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.jcmg.2007.11.005" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of the thoracic aorta by multidetector computed tomography: age- and sex-specific reference values in adults without evident cardiovascular disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ FY Lin \n \t\t\t\t\t\t\t\t """ 1 => """ RB Devereux \n \t\t\t\t\t\t\t\t """ 2 => """ MJ Roman \n \t\t\t\t\t\t\t\t """ 3 => """ J Meng \n \t\t\t\t\t\t\t\t """ 4 => """ VM Jow \n \t\t\t\t\t\t\t\t """ 5 => """ A Jacobs \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.jcct.2008.08.002" "Revista" => array:7 [ "tituloSerie" => "J Cardiovasc Comput Tomogr" "fecha" => "2008" "volumen" => "2" "numero" => "5" "paginaInicial" => "298" "paginaFinal" => "308" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19083966" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.jcct.2008.08.002" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.jcct.2008.08.002" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship of age, gender, race, and body size to infrarenal aortic diameter. The Aneurysm Detection and Management (ADAM) Veterans Affairs Cooperative Study Investigators" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ FA Lederle \n \t\t\t\t\t\t\t\t """ 1 => """ GR Johnson \n \t\t\t\t\t\t\t\t """ 2 => """ SE Wilson \n \t\t\t\t\t\t\t\t """ 3 => """ IL Gordon \n \t\t\t\t\t\t\t\t """ 4 => """ EP Chute \n \t\t\t\t\t\t\t\t """ 5 => """ FN Littooy \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/s0741-5214(97)70057-0" "Revista" => array:7 [ "tituloSerie" => "J Vasc Surg" "fecha" => "1997" "volumen" => "26" "numero" => "4" "paginaInicial" => "595" "paginaFinal" => "601" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9357459" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/s0741-5214(97)70057-0" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/S0741-5214(97)70057-0" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aortic aneurysm screening in a high-risk population: a non-contrast computed tomography study in Korean males with hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ IJ Cho \n \t\t\t\t\t\t\t\t """ 1 => """ SY Jang \n \t\t\t\t\t\t\t\t """ 2 => """ HJ Chang \n \t\t\t\t\t\t\t\t """ 3 => """ S Shin \n \t\t\t\t\t\t\t\t """ 4 => """ CY Shim \n \t\t\t\t\t\t\t\t """ 5 => """ GR Hong \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.4070/kcj.2014.44.3.162" "Revista" => array:7 [ "tituloSerie" => "Korean Circ J" "fecha" => "2014" "volumen" => "44" "numero" => "3" "paginaInicial" => "162" "paginaFinal" => "169" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24876857" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.4070/kcj.2014.44.3.162" "WWW" => array:1 [ "link" => "https://doi.org/10.4070/kcj.2014.44.3.162" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Do Current Lung Cancer Screening Guidelines Apply for Populations With High Prevalence of Granulomatous Disease? 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Clinical, laboratory, and transesophageal echocardiographic correlates of thoracic aortic dimensions in the population with implications for thoracic aortic aneurysm formation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ Y Agmon \n \t\t\t\t\t\t\t\t """ 1 => """ BK Khandheria \n \t\t\t\t\t\t\t\t """ 2 => """ I Meissner \n \t\t\t\t\t\t\t\t """ 3 => """ GL Schwartz \n \t\t\t\t\t\t\t\t """ 4 => """ JD Sicks \n \t\t\t\t\t\t\t\t """ 5 => """ AJ Fought \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/s0735-1097(03)00922-7" "Revista" => array:7 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2003" "volumen" => "42" "numero" => "6" "paginaInicial" => "1076" "paginaFinal" => "1083" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13678934" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/s0735-1097(03)00922-7" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/S0735-1097(03)00922-7" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anatomical variations in branching pattern of arcus aorta: 64-slice CTA appearance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ E Ergun \n \t\t\t\t\t\t\t\t """ 1 => """ B Şimşek \n \t\t\t\t\t\t\t\t """ 2 => """ PN Koşar \n \t\t\t\t\t\t\t\t """ 3 => """ BK Yılmaz \n \t\t\t\t\t\t\t\t """ 4 => """ AT Turgut \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s00276-012-1063-3" "Revista" => array:7 [ "tituloSerie" => "Surg Radiol Anat" "fecha" => "2013" "volumen" => "35" "numero" => "6" "paginaInicial" => "503" "paginaFinal" => "509" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23271166" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s00276-012-1063-3" "WWW" => array:1 [ "link" => "https://doi.org/10.1007/s00276-012-1063-3" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Anatomical Variations in Aortic Arch Branching Pattern" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ B Jalali Kondori \n \t\t\t\t\t\t\t\t """ 1 => """ MH Asadi \n \t\t\t\t\t\t\t\t """ 2 => """ E Rahimian \n \t\t\t\t\t\t\t\t """ 3 => """ MR Tahsini \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "0161901/AIM.0013" "Revista" => array:7 [ "tituloSerie" => "Arch Iran Med" "fecha" => "2016" "volumen" => "19" "numero" => "1" "paginaInicial" => "72" "paginaFinal" => "74" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26702752" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevalence of Bovine Aortic Arch Variant in Patients with Aortic Dissection and its Implications in the Outcome of Patients with Acute Type B Aortic Dissection" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ SN Mylonas \n \t\t\t\t\t\t\t\t """ 1 => """ A Barkans \n \t\t\t\t\t\t\t\t """ 2 => """ M Ante \n \t\t\t\t\t\t\t\t """ 3 => """ J Wippermann \n \t\t\t\t\t\t\t\t """ 4 => """ D Böckler \n \t\t\t\t\t\t\t\t """ 5 => """ JS Brunkwall \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.ejvs.2017.12.005" "Revista" => array:7 [ "tituloSerie" => "Eur J Vasc Endovasc Surg" "fecha" => "2018" "volumen" => "55" "numero" => "3" "paginaInicial" => "385" "paginaFinal" => "391" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29338980" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.ejvs.2017.12.005" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.ejvs.2017.12.005" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Multimodality Noninvasive Imaging of Thoracic Aortic Aneurysms: Time to Standardize?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ FP Mongeon \n \t\t\t\t\t\t\t\t """ 1 => """ F Marcotte \n \t\t\t\t\t\t\t\t """ 2 => """ DG Terrone \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.cjca.2015.09.025" "Revista" => array:7 [ "tituloSerie" => "Can J Cardiol" "fecha" => "2016" "volumen" => "32" "numero" => "1" "paginaInicial" => "48" "paginaFinal" => "59" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26724510" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.cjca.2015.09.025" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.cjca.2015.09.025" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/000000760000000C/v1_202211191031/S1807593222000874/v1_202211191031/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/000000760000000C/v1_202211191031/S1807593222000874/v1_202211191031/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222000874?idApp=UINPBA00004N"]

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Lucas Lembrança

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lucaslembranca@gmail.com

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, Marcelo Passos Teivelis, Adriano Tachibana, Ricardo Sales dos Santos, Richard Wonuh Joo, Emanuela Zippo, Nelson Wolosker

Hospital Israelita Albert Einstein, Sao Paulo, SP, BR

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    "titulo" => "Thoracic aortic size in Brazilian smokers&#58; measures using low-dose chest computed tomography anatomical and epidemiological assessment"
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          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Aortic diameters by segment&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Aortic aneurysms are the third leading cause of vascular disease in the United States&#46; Thoracic aortic aneurysms &#40;TAAs&#41; represent one-third of the hospitalizations for aortic diseases &#40;<a class="elsevierStyleCrossRef" href="#bib1">1</a>&#41;&#46; TAAs are classified according to their anatomical location&#58; ascending aorta aneurysms &#40;most common&#41;&#44; aortic arch aneurysms&#44; descending TAAs&#44; and thoracoabdominal aneurysms &#40;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#41;&#46;</p><p id="para20" class="elsevierStylePara elsevierViewall">TAAs and infrarenal abdominal aortic aneurysms share the same risk factors&#58; smoking&#44; systemic hypertension&#44; and dyslipidemia &#40;<a class="elsevierStyleCrossRef" href="#bib3">3</a>&#41;&#46; TAAs are often asymptomatic&#44; which hinders their diagnosis&#44; present slow growth&#44; are strongly related to congenital and degenerative diseases &#40;<a class="elsevierStyleCrossRef" href="#bib4">4</a>&#41;&#44; and can cause severe complications such as upper limb ischemia&#44; carotid and vertebral embolization&#44; and&#44; the most feared of all&#44; rupture&#46;</p><p id="para30" class="elsevierStylePara elsevierViewall">The surgical treatment of aneurysms aims to reduce the risk of these complications and to treat symptoms&#44; when they exist&#44; to avoid rupture&#46; However&#44; surgical treatment is not risk-free &#40;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#44;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41;&#46; Thus&#44; it is only recommended when the maximum diameter of the aneurysm&#44; in the descending thoracic aorta&#44; is greater than 6 cm &#40;<a class="elsevierStyleCrossRef" href="#bib7">7</a>&#41;&#46; Above these diameters&#44; the risks of surgery are lower than the risk of rupture&#44; justifying treatment&#46;</p><p id="para40" class="elsevierStylePara elsevierViewall">Several studies have sought to identify the actual incidence of TAAs&#59; however&#44; the incidence rate depends on the definition of the normal size of the aorta&#44; which is quite variable&#44; depending on the population studied&#46; Hence&#44; it is important to first determine the characteristics of a normal population to evaluate the incidence of TAAs&#46; Recently&#44; two studies were conducted to analyze the average size of all segments of the thoracic aorta using chest computed tomography &#40;CT&#41; in patients without risk factors for TAAs and thus evaluate the prevalence of TAAs in these populations &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#44;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&#41;&#46; Itani et al&#46;&#44; in Japan&#44; in 2002 &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&#44; used the population&#39;s standard deviation &#40;SD&#41; to define an abnormality value&#59; values above three SDs were considered abnormal&#46; Thus&#44; they found a prevalence of 0&#46;16&#37;&#46; K&#228;lsch et al&#46;&#44; in 2013&#44; in Germany&#44; defined any dilatation of the thoracic aorta with a diameter greater than 5 cm as a TAA&#44; resulting in a prevalence of 0&#46;34&#37; &#40;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&#41;&#46;</p><p id="para50" class="elsevierStylePara elsevierViewall">In Brazil&#44; this type of study has not yet been performed and is relevant both internally to demonstrate the local anatomical conditions and to the rest of the world to demonstrate the difference in relation to other countries and the possible need for individualized population studies&#46;</p><p id="para60" class="elsevierStylePara elsevierViewall">The aim of this study was to evaluate the characteristics of the thoracic aorta of Brazilian smokers&#44; identifying the normal size of the aorta&#44; presence of anatomical variations in the supra-aortic trunks&#44; and prevalence of TAAs&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">MATERIALS AND METHODS</span><p id="para70" class="elsevierStylePara elsevierViewall">A total of 711 volunteers aged between 55 and 74 years&#44; smokers &#40;tobacco use 30 packs&#47;year or more&#41;&#44; and without signs or symptoms of aortic diseases were studied&#46; All patients underwent radiological evaluation with low-dose CT from January 2013 to July 2014 with the initial objective of lung nodule tracking&#46; Some of them were followed up&#44; but at this moment&#44; we analyzed only the first images&#46; The anthropometric characteristics are presented in <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#46; The included patients were in the sixth decade of life and had mild overweight and a similar distribution between sexes&#44; with an average body surface area &#40;BSA&#41; of 1&#46;83 m<span class="elsevierStyleSup">2</span>&#46;</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><p id="para80" class="elsevierStylePara elsevierViewall">The tests were performed using a single device &#40;Toshiba Aquilion 64 CFX CT&#44; Toshiba Medical Systems Corporation&#44; Otawara&#44; Tochigi&#44; Japan&#41; and a low radiation dose technique &#40;120 kV and a maximum of 15 mA with a 1&#215;1 mm collimation&#41;&#46; The images were stored in a Picture Archiving and Communication System &#40;PACS&#41; in the Digital Imaging and Communications in Medicine &#40;DICOM&#41; format&#46;</p><p id="para90" class="elsevierStylePara elsevierViewall">These images were evaluated by two examiners&#44; and measurements were performed manually using Horos version 3&#46;2&#46;0 &#40;Horos Project&#44; Geneva&#44; Switzerland&#41;&#46; At each segment&#44; diameter measurements were taken of the thoracic aorta &#40;ascending aorta&#44; aortic arch&#44; and descending aorta&#41; in true orthogonal planes&#44; corrected by the central axis&#44; by a single examiner&#46;</p><p id="para100" class="elsevierStylePara elsevierViewall">Then&#44; serial measurements were made at precisely defined points&#46; In the ascending aorta&#44; diameter measurements were taken every 2 cm with the origin immediately proximal to the brachiocephalic trunk&#46; In the descending aorta&#44; serial measurements were performed every 5 cm with the origin immediately distal to the origin of the left subclavian artery&#46;</p><p id="para110" class="elsevierStylePara elsevierViewall">The most frequent anatomical variations were evaluated&#58; the presence of a common origin between the right carotid artery and the brachiocephalic trunk &#40;bovine arch&#41; and the presence of an abnormal origin of the left vertebral artery and aberrant left subclavian artery&#46; Aortic arch types were classified as follows&#58; type 1&#44; when the origin of the supra-aortic trunk is found in an imaginary plane above the greater curvature of the aorta&#59; type 2&#44; when one of the vessels originates in a plane between the greater and lesser curvature of the aorta&#59; and type 3&#44; when one of the vessels originates proximal to the plane drawn in the lesser curvature of the aorta &#40;<a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>&#41;&#46; In addition&#44; anatomical characteristics were correlated with anthropometric characteristics&#44; body mass index &#40;BMI&#41;&#44; and BSA&#46;</p><elsevierMultimedia ident="fig1"></elsevierMultimedia><p id="para120" class="elsevierStylePara elsevierViewall">To identify the importance of each variable in determining the diameter value for each segment&#44; we performed multiple linear regression with the following parameters&#58; sex&#44; age&#44; and average BSA&#46; Based on this analysis&#44; we obtained the expected measures for each segment&#44; stratified by sex and age group&#46;</p><p id="para130" class="elsevierStylePara elsevierViewall">This study was approved by the institution&#39;s ethics committee and exempt from informed consent&#46;</p></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">RESULTS</span><p id="para140" class="elsevierStylePara elsevierViewall">For each patient&#44; we performed&#44; at least&#44; six measures of aortic diameters&#58; two in the ascending segment&#44; one in the aortic arch&#44; and three in the descending aorta&#46; This resulted in 4&#44;266 diameter measurement points and a total of 8&#44;532 measurements&#46;</p><p id="para150" class="elsevierStylePara elsevierViewall">The maximum diameters of each segment are shown in <a class="elsevierStyleCrossRef" href="#fig2">Figure 2</a>&#46; The largest arterial diameter was observed in the ascending segment&#44; at 33&#46;61 mm &#40;SD&#44; 3&#46;88&#41;&#46; In the aortic arch and the descending aorta&#44; we found smaller diameters &#40;28&#46;66 mm &#91;SD 2&#46;89&#93; and 28&#46;36 &#91;SD 3&#46;09&#93;&#44; respectively&#41;&#46;</p><elsevierMultimedia ident="fig2"></elsevierMultimedia><p id="para160" class="elsevierStylePara elsevierViewall">Analysis of the correlation between values and anthropometric characteristics showed a positive correlation between male sex&#44; age&#44; and BSA with aorta diameter&#44; with a stronger correlation for BSA and the descending aorta &#40;<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia><p id="para170" class="elsevierStylePara elsevierViewall">Multiple linear regressions confirmed that age&#44; BSA&#44; and male sex were good predictors of aortic size in the descending segment&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a>&#46; The equations used to calculate the diameter of each segment are shown in <a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a>&#44; and the expected aortic diameters for each segment are represented in <a class="elsevierStyleCrossRef" href="#fig3">Figure 3</a>&#46;</p><elsevierMultimedia ident="tbl3"></elsevierMultimedia><elsevierMultimedia ident="tbl4"></elsevierMultimedia><elsevierMultimedia ident="fig3"></elsevierMultimedia><p id="para180" class="elsevierStylePara elsevierViewall">Anatomical variations were observed in 81 &#40;11&#46;4&#37;&#41; patients&#44; and the bovine arch was the most common variation&#46; Among the aortic arch types&#44; type 1 was the most common &#40;<a class="elsevierStyleCrossRef" href="#tbl5">Table 5</a>&#41;&#46;</p><elsevierMultimedia ident="tbl5"></elsevierMultimedia><p id="para190" class="elsevierStylePara elsevierViewall">Finally&#44; we found only one &#40;0&#46;14&#37;&#41; aneurysm in the descending aorta&#46;</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">DISCUSSION</span><p id="para200" class="elsevierStylePara elsevierViewall">TAA is a silent disease of increasing incidence and high morbidity and mortality&#44; the prognosis of which depends substantially on the size of the aorta in each segment&#46; In the past&#44; analyses of normal vessel dimensions were performed based on angiography&#44; ultrasound &#40;<a class="elsevierStyleCrossRef" href="#bib10">10</a>&#41;&#44; and magnetic resonance imaging &#40;<a class="elsevierStyleCrossRef" href="#bib11">11</a>&#41;&#46; With the increased availability of tomography&#44; studies to identify the anatomical features of the aorta have been performed&#46; In recent years&#44; several studies have been conducted with this aim in North America &#40;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#44;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#44;<a class="elsevierStyleCrossRef" href="#bib13">13</a>&#41;&#44; &#40;<a class="elsevierStyleCrossRef" href="#bib14">14</a>&#41; Europe &#40;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&#41;&#44; and the East &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#44;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#41;&#46; The objective of our study was to analyze the dimensions of the aorta in Brazil and evaluate the impact of BMI&#44; BSA&#44; and age&#46;</p><p id="para210" class="elsevierStylePara elsevierViewall">Currently&#44; there is increasing concern about the deleterious effects of radiation&#46; Thus&#44; the use of tomography exams with low radiation doses&#44; as performed in our study&#44; is gaining importance&#46; Wolak et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#41; were the first to evaluate&#44; on a large scale&#44; the dimensions of large vessels with the use of tomography without contrast&#46; Their data were comparable to those of a contrasted series and showed a high interobserver correlation&#46; Thus&#44; we can infer that the modern protocols do not require contrast and high doses of radiation to measure aortic diameters&#46;</p><p id="para220" class="elsevierStylePara elsevierViewall">In our study&#44; we used a sample previously selected for the screening of lung diseases &#40;<a class="elsevierStyleCrossRef" href="#bib16">16</a>&#41;&#46; Thus&#44; our study included patients in an older age group&#44; similar to two studies conducted in Japan and Korea&#44; which also used samples previously selected for lung neoplasia screening &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#44;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#41;&#46;</p><p id="para230" class="elsevierStylePara elsevierViewall">The demographic characteristics of our sample were similar to those in a national study that evaluated causes of death in Brazilian patients with aortic aneurysms &#40;<a class="elsevierStyleCrossRef" href="#bib17">17</a>&#41;&#44; with no predominance of any sex and with a slightly higher than average age than American &#40;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#41; and German &#40;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&#41; populations&#46;</p><p id="para240" class="elsevierStylePara elsevierViewall">The maximum diameter of the ascending aorta was similar to that reported for two American series that used patients undergoing coronary disease control exams &#40;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#44;<a class="elsevierStyleCrossRef" href="#bib18">18</a>&#41; and was lower than that reported for a large population study &#40;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#41;&#46; This difference could be due to selection bias&#46; A review which compared the works of Rogers&#44; Wolak and Mao enrolled younger patients who consequently presented with fewer comorbidities and smaller vessels&#46;</p><p id="para250" class="elsevierStylePara elsevierViewall">When compared with the mean diameter of the ascending aorta in non-American populations&#44; the mean diameter of the ascending aorta in Brazilians was 1 mm greater than that found in Japanese patients &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41; &#40;younger patients&#41; and 5 mm smaller than that found in a German population &#40;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&#41;&#46;</p><p id="para260" class="elsevierStylePara elsevierViewall">The aortic arch diameter tends to be less evaluated in series because its evaluation demands a more arduous methodology&#46; Even so&#44; we could compare our results with those reported in a study by Hager et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib19">19</a>&#41; in German patients&#44; which showed a slightly higher average diameter than that in Brazilians&#46; However&#44; the diameter of the descending aorta was higher than that reported by the majority of series &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#44;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&#44;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#44;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#41;&#44; except for the Japanese series &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&#44; which can be explained by the mean age of our patients&#44; which was 60&#46;9 years&#44; compared to other studies with populations younger than 60 years &#40;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&#44;<a class="elsevierStyleCrossRef" href="#bib19">19</a>&#41;&#46;</p><p id="para270" class="elsevierStylePara elsevierViewall">Therefore&#44; the diameter of the ascending aorta was smaller in Europeans and larger in Asians&#44; while the diameter of the descending aorta had opposite characteristics&#46;</p><p id="para280" class="elsevierStylePara elsevierViewall">There was a significant difference in measurements between sexes&#44; with larger diameters in men in all segments&#44; based on data previously demonstrated by other studies &#40;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&#44;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#41; and reaffirmed in our study&#46;</p><p id="para290" class="elsevierStylePara elsevierViewall">The relationship between anthropometric data and vessel dimensions is already known&#46; BMI&#44; age&#44; and BSA were related to the diameter of the thoracic aorta&#44; with correlations similar to European and Asian studies&#46; Thus&#44; we sought to correlate aortic diameters with BMI and mean BSA&#44; which is more accurate than BMI in evaluating the correlation between body measurements and aortic diameters &#40;<a class="elsevierStyleCrossRef" href="#bib20">20</a>&#41;&#46;</p><p id="para300" class="elsevierStylePara elsevierViewall">Our patients had a mean BMI of 26&#46;28&#44; which is compatible with Brazilian data&#44; which show a high incidence of overweight status&#44; especially in age groups older than 60 years&#46; The population in our study showed a lower BSA than most studies &#40;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&#44;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#44;<a class="elsevierStyleCrossRef" href="#bib19">19</a>&#41;&#44; with the exception of a Korean study &#40;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#41;&#46; These variations confirm the need for careful evaluation when comparing data from different populations&#46;</p><p id="para310" class="elsevierStylePara elsevierViewall">Keeping in mind that our population has a smaller BSA than others and that there was a correlation between BSA and aortic diameter in three segments &#40;ascending aorta&#44; trunk&#44; and descending aorta&#41;&#44; one would expect proportionally smaller diameters compared to those reported in other studies&#46; We think that the high rate of smoking and the consequences of its use on the arterial wall led to an increase in aortic diameter&#46;</p><p id="para320" class="elsevierStylePara elsevierViewall">The diameter is also influenced by age&#44; which showed a significant correlation in all segments&#44; especially in the descending aorta&#44; as observed by Rogers et al&#46; and Itani et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#44;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&#46; We know that there is a greater concentration of elastic tissue in the thoracic aorta as it approaches the diaphragm&#46; Over time&#44; degeneration of these fibers occurs&#44; which leads to a progressive increase in the vessel by losing its elastic characteristics&#44; becoming less compliant&#46;</p><p id="para330" class="elsevierStylePara elsevierViewall">Because there is considerable phenotypic variation among the populations &#40;Europeans&#44; for example&#44; have greater stature than Eastern populations&#41;&#44; we performed multiple linear regression that resulted in a formula to find the expected diameter of each aortic segment as a function of BSA&#44; BMI&#44; and age range&#46;</p><p id="para340" class="elsevierStylePara elsevierViewall">We observed an incidence of anatomical variations in the supra-aortic trunks in 11&#46;4&#37; of the sample&#46; As in other studies &#40;<a class="elsevierStyleCrossRef" href="#bib21">21</a>&#44;<a class="elsevierStyleCrossRef" href="#bib22">22</a>&#41;&#44; we found that the most common variation was the bovine arch&#44; present in 9&#46;6&#37; of our sample&#46; Mylonas &#40;<a class="elsevierStyleCrossRef" href="#bib23">23</a>&#41; found an increased risk of aortic diseases in the presence of a bovine trunk&#59; however&#44; we found no relationship between anatomical variation and the presence of aneurysms&#46;</p><p id="para350" class="elsevierStylePara elsevierViewall">Our study has some limitations&#46; We are the first group to accurately assess the anatomical features of the aorta of Brazilians&#46; These analyses were performed in non-contrast low-dose exams&#44; which resulted in lower morbidity&#46; In contrast to other series&#44; which made two measurements in the axial plane &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#44;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&#44;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#44;<a class="elsevierStyleCrossRef" href="#bib18">18</a>&#41;&#44; we used precisely defined sites in several aortic segments and performed all corrective measurements for the true axis of the vessel&#44; which is the most accurate method &#40;<a class="elsevierStyleCrossRef" href="#bib24">24</a>&#41; and recommended by the guidelines&#46;</p><p id="para360" class="elsevierStylePara elsevierViewall">This resulted in 4&#44;200 evaluated diameters that led us to find&#44; with great accuracy&#44; the real diameter of each segment &#40;ascending aorta&#44; aortic arch&#44; and descending aorta&#41;&#46;</p><p id="para370" class="elsevierStylePara elsevierViewall">In addition&#44; the sample had a high prevalence of smokers and elderly individuals&#44; which are factors usually related to larger aortic dimensions&#46; However&#44; they are the most frequent patients with TAAs and are therefore a good indicator of the measurements of patients at risk for developing the disease&#46; In addition&#44; the evaluation of the proximal segment of the aorta close to the sinus&#44; an area of high tissue density that was impaired by the absence of contrast&#44; prevented accurate measurements of the extent of the ascending aorta segment&#46;</p><p id="para380" class="elsevierStylePara elsevierViewall">We believe that with technological evolution&#44; using artificial intelligence and robotic analysis mechanisms&#44; we will be able to evaluate large volumes of CT data and have more significant anatomical data from global populations in the near future&#46;</p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">CONCLUSIONS</span><p id="para390" class="elsevierStylePara elsevierViewall">In elderly Brazilian smokers&#44; who are part of a population at greatest risk for aneurysms&#44; the mean diameters of the ascending aorta&#44; aortic arch&#44; and descending aorta were 33&#46;6 mm&#44; 28&#46;7 mm&#44; and 28&#46;4 mm&#44; respectively&#46;</p><p id="para400" class="elsevierStylePara elsevierViewall">Anatomical variations were observed in 81 &#40;11&#46;4&#37;&#41; patients&#44; with bovine arch being the most common&#44; and TAA prevalence was 0&#46;14&#37;&#46;</p></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">AUTHOR CONTRIBUTIONS</span><p id="para410" class="elsevierStylePara elsevierViewall">Lembran&#231;a L&#44; Teivelis MP&#44; Tachibana A&#44; dos Santos RS were responsible for the research&#44; manuscript development&#44; data collection and manuscript writing&#46; Joo RW and Zippo E were responsible for the data collection&#46; Wolosker N was responsible for the manuscript development and approval&#46;</p></span></span>"
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    "fechaAceptado" => "2020-11-06"
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      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "KEYWORDS"
          "identificador" => "xpalclavsec1577398"
          "palabras" => array:4 [
            0 => "Aorta"
            1 => "Diameter"
            2 => "Arch"
            3 => "Thoracic"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVES&#58;</span><p id="spara110" class="elsevierStyleSimplePara elsevierViewall">Thoracic aortic aneurysms &#40;TAAs&#41; represent one-third of the hospitalizations for aortic diseases&#46; The prevalence rate depends on the definition of the normal size of the aorta&#44; which is quite variable&#44; depending on the population studied&#46; The aim of this study was to evaluate the characteristics of the thoracic aorta of Brazilian smokers&#44; identifying the normal size of the aorta&#44; presence of anatomical variations&#44; and prevalence of TAA&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">MATERIALS AND METHODS&#58;</span><p id="spara120" class="elsevierStyleSimplePara elsevierViewall">A total of 711 patients underwent radiological evaluation with low-dose computed tomography &#40;CT&#41; from January 2013 to July 2014 with the initial objective of lung nodule tracking&#46; Two examiners evaluated these images&#44; and measurements of maximum and serial diameters were performed manually in true orthogonal planes&#46; Serial diameter measurements were taken every 2 cm in the ascending aorta and 5 cm in the descending segment&#46; We searched for anatomical variations&#44; aortic arch type&#44; and correlations between anatomical characteristics&#44; sex&#44; body mass index&#44; and body surface area &#40;BSA&#41;&#46;</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS&#58;</span><p id="spara130" class="elsevierStyleSimplePara elsevierViewall">The maximum diameters were 33&#46;61 &#40;standard deviation &#91;SD&#93; 3&#46;88&#41;&#44; 28&#46;66 &#40;SD 2&#46;89&#41;&#44; and 28&#46;36 mm &#40;SD 3&#46;09&#41; for the ascending segment&#44; aortic arch&#44; and descending segment&#44; respectively&#46; A positive correlation was found between male sex&#44; age&#44; and BSA and aorta diameter&#46; The bovine arch was the most common variation of the aortic arch type&#44; and we found one &#40;0&#46;14&#37;&#41; case of TAA&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSIONS&#58;</span><p id="spara140" class="elsevierStyleSimplePara elsevierViewall">This study with low-dose CT allowed the determination of the mean diameters of the ascending aorta&#44; aortic arch&#44; and descending aorta in Brazilian smokers and TAA prevalence&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "ceabs10"
            "titulo" => "OBJECTIVES&#58;"
          ]
          1 => array:2 [
            "identificador" => "ceabs20"
            "titulo" => "MATERIALS AND METHODS&#58;"
          ]
          2 => array:2 [
            "identificador" => "ceabs30"
            "titulo" => "RESULTS&#58;"
          ]
          3 => array:2 [
            "identificador" => "ceabs40"
            "titulo" => "CONCLUSIONS&#58;"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">No potential conflict of interest was reported&#46;</p>"
      ]
    ]
    "multimedia" => array:8 [
      0 => array:7 [
        "identificador" => "fig1"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 317
            "Ancho" => 750
            "Tamanyo" => 31333
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Aortic arch classification&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig2"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 597
            "Ancho" => 750
            "Tamanyo" => 17852
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Aortic diameters by segment&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig3"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
            "Alto" => 471
            "Ancho" => 750
            "Tamanyo" => 21208
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Expected descending aorta diameter for body surface area&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl1"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">SD&#58; standard deviation&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60&#46;9 &#40;4&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Median &#40;Q1&#59; Q3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">60 &#40;57&#59; 64&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">54-74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">352 &#40;49&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">359 &#40;50&#46;5&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Weight &#40;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">73&#46;0 &#40;15&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Median &#40;Q1&#59; Q3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">71 &#40;62&#59; 81&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">35-131&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Height &#40;cm&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">166&#46;4 &#40;9&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Median &#40;Q1&#59; Q3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">167 &#40;160&#59; 173&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">141-193&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Body mass index &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">26&#46;3 &#40;4&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Median &#40;Q1&#59; Q3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">25&#46;8 &#40;23&#46;3&#59; 28&#46;7&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">15&#46;6-49&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Body surface area &#40;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Mean &#40;SD&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;83 &#40;0&#46;22&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Median &#40;Q1&#59; Q3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;81 &#40;1&#46;67&#59; 1&#46;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Range&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;21-2&#46;55&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Patient characteristics&#46;</p>"
        ]
      ]
      4 => array:7 [
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        "tabla" => array:2 [
          "leyenda" => "<p id="spara70" class="elsevierStyleSimplePara elsevierViewall">Pearson correlation &#40;<span class="elsevierStyleItalic">p</span> value&#41;&#46;</p>"
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Variables&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Total&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#61;711&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#61;359&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#61;352&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ascending aorta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;240 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;259 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;172 &#40;<span class="elsevierStyleItalic">p</span>&#61;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Aortic arch&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;252 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;157 &#40;<span class="elsevierStyleItalic">p</span>&#61;0&#44;003&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;281 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Descending aorta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;322 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;190 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#44;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;386 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Body surface area&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#61;707&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#61;358&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">n&#61;349&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Ascending aorta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;350 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;207 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;263 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Aortic arch&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;376 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;288 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;237 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Descending aorta&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;403 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;286 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;203 &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara60" class="elsevierStyleSimplePara elsevierViewall">Correlations between aortic diameter&#44; age&#44; and body surface area&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "tbl3"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Predictor&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Unstandardized coefficient &#40;standardized&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Standard error&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black"><span class="elsevierStyleItalic">p</span> value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;108 &#40;0&#46;166&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;029&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Male sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#8722;7&#46;280 &#40;&#8722;1&#46;180&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;479&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Body surface index&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;833 &#40;0&#46;272&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;491&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age and male sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;149 &#40;1&#46;494&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;040&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Constant&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13&#46;811&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;982&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara80" class="elsevierStyleSimplePara elsevierViewall">Predictors of descending aorta diameter&#46;</p>"
        ]
      ]
      6 => array:7 [
        "identificador" => "tbl4"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Aortic segment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Linear regression equation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Ascending&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Maximum diameter</span>&#61;11&#46;849&#43;0&#46;202 &#215; age&#43;3&#46;583 &#40;for male sex&#41;&#43;4&#46;829 &#215; BSA &#8722; 0&#46;038 &#215; age &#40;for male sex&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Arch&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Maximum diameter</span>&#61;15&#46;060&#43;0&#46;095 &#215; age &#8722; 4&#46;417 &#40;for male sex&#41;&#43;3&#46;988 &#215; BSA&#43;0&#46;088 &#215; age &#40;for male sex&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Descending&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleBold">Maximum diameter</span>&#61;13&#46;811&#43;0&#46;108 &#215; age &#8722; 7&#46;280 &#40;for male sex&#41;&#43;3&#46;833 &#215; BSA&#43;0&#46;149 &#215; age &#40;for male sex&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
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        "descripcion" => array:1 [
          "en" => "<p id="spara90" class="elsevierStyleSimplePara elsevierViewall">Linear regression equations for each segment&#46;</p>"
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        "tipo" => "MULTIMEDIATABLA"
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                  \t\t\t\t" class=""><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Anatomic variations&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="" valign="\n
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                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Bovine arch&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">69 &#40;9&#46;7&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Abnormal origin of vertebral artery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">13 &#40;1&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Aberrant right subclavian artery&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;0&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Aortic arch classification&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Type 1&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">394 &#40;55&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Type 2&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">229 &#40;32&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>Type 3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
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                  \t\t\t\t">88 &#40;12&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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      "titulo" => "REFERENCES"
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        0 => array:2 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "2010 ACCF&#47;AHA&#47;AATS&#47;ACR&#47;ASA&#47;SCA&#47;SCAI&#47;SIR&#47;STS&#47;SVM guidelines for the diagnosis and management of patients with Thoracic Aortic Disease&#58; a report of the American College of Cardiology Foundation&#47;American Heart Association Task Force on Practice Guidelines&#44; American Association for Thoracic Surgery&#44; American College of Radiology&#44; American Stroke Association&#44; Society of Cardiovascular Anesthesiologists&#44; Society for Cardiovascular Angiography and Interventions&#44; Society of Interventional Radiology&#44; Society of Thoracic Surgeons&#44; and Society for Vascular Medicine"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              LF Hiratzka \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              GL Bakris \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JA Beckman \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              RM Bersin \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              VF Carr \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              DE Casey Jr \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1161/CIR.0b013e3181d4739e"
                      "Revista" => array:7 [
                        "tituloSerie" => "Circulation"
                        "fecha" => "2010"
                        "volumen" => "121"
                        "numero" => "13"
                        "paginaInicial" => "e266"
                        "paginaFinal" => "e369"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20233780"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Distribution&#44; determinants&#44; and normal reference values of thoracic and abdominal aortic diameters by computed tomography &#40;from the Framingham Heart Study&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              IS Rogers \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              JM Massaro \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              QA Truong \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              AA Mahabadi \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              MF Kriegel \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              CS Fox \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
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                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "2013"
                        "volumen" => "5"
                        "numero" => "10"
                        "paginaInicial" => "1510"
                        "paginaFinal" => "1516"
                      ]
                    ]
                    1 => array:1 [
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              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Are aortic aneurysms caused by atherosclerosis&#63;"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              D Reed \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              C Reed \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              G Stemmermann \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              T Hayashi \n
                              \t\t\t\t\t\t\t\t
                              """
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                    0 => array:2 [
                      "doi" => "10.1161/01.cir.85.1.205"
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                        "tituloSerie" => "Circulation"
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                        "volumen" => "85"
                        "numero" => "1"
                        "paginaInicial" => "205"
                        "paginaFinal" => "211"
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                          0 => array:2 [
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              "etiqueta" => "4"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Familial thoracic aortic aneurysms and dissections&#8211;incidence&#44; modes of inheritance&#44; and phenotypic patterns"
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                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              G Albornoz \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              MA Coady \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M Roberts \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              RR Davies \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              M Tranquilli \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              JA Rizzo \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
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                    0 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2006.04.098"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2006"
                        "volumen" => "82"
                        "numero" => "4"
                        "paginaInicial" => "1400"
                        "paginaFinal" => "1405"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16996941"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2006.04.098"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;athoracsur&#46;2006&#46;04&#46;098"
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            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Thoracic aortic aneurysm clinically pertinent controversies and uncertainties"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              JA Elefteriades \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              EA Farkas \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jacc.2009.08.084"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2010"
                        "volumen" => "55"
                        "numero" => "9"
                        "paginaInicial" => "841"
                        "paginaFinal" => "857"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20185035"
                            "web" => "Medline"
                          ]
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                    ]
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                      "doi" => "10.1016/j.jacc.2009.08.084"
                      "WWW" => array:1 [
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            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increasing incidence of ruptured abdominal aortic aneurysm&#58; a population-based study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              S Acosta \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              M Ogren \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              H Bengtsson \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              D Bergqvist \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              B Lindblad \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              Z Zdanowski \n
                              \t\t\t\t\t\t\t\t
                              """
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                    0 => array:2 [
                      "doi" => "10.1016/j.jvs.2006.04.037"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Vasc Surg"
                        "fecha" => "2006"
                        "volumen" => "44"
                        "numero" => "2"
                        "paginaInicial" => "237"
                        "paginaFinal" => "243"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
                          ]
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                    1 => array:2 [
                      "doi" => "10.1016/j.jvs.2006.04.037"
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            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expert consensus document on the treatment of descending thoracic aortic disease using endovascular stent-grafts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              LG Svensson \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              NT Kouchoukos \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              DC Miller \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              JE Bavaria \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JS Coselli \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              MA Curi \n
                              \t\t\t\t\t\t\t\t
                              """
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                    0 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2007.10.099"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2008"
                        "volumen" => "85"
                        "numero" => "1 Suppl"
                        "paginaInicial" => "S1"
                        "paginaFinal" => "41"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18083364"
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                    1 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2007.10.099"
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              "etiqueta" => "8"
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                    0 => array:2 [
                      "titulo" => "Measurement of aortic diameters and detection of asymptomatic aortic aneurysms in a mass screening program using a mobile helical computed tomography unit"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              Y Itani \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              S Watanabe \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              Y Masuda \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              K Hanamura \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              K Asakura \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              S Sone \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1007/s380-002-8315-1"
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                        "tituloSerie" => "Heart Vessels"
                        "fecha" => "2002"
                        "volumen" => "16"
                        "numero" => "2"
                        "paginaInicial" => "42"
                        "paginaFinal" => "45"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11833840"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Body-surface adjusted aortic reference diameters for improved identification of patients with thoracic aortic aneurysms&#58; results from the population-based Heinz Nixdorf Recall study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              H K&#228;lsch \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              N Lehmann \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              S M&#246;hlenkamp \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              A Becker \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              S Moebus \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              A Schmermund \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ijcard.2011.05.039"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Cardiol"
                        "fecha" => "2013"
                        "volumen" => "163"
                        "numero" => "1"
                        "paginaInicial" => "72"
                        "paginaFinal" => "78"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21641667"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.ijcard.2011.05.039"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;ijcard&#46;2011&#46;05&#46;039"
                      ]
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                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Two-dimensional echocardiographic aortic root dimensions in normal children and adults"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              MJ Roman \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RB Devereux \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              R Kramer-Fox \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              J O&#8217;Loughlin \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/0002-9149(89)90430-x"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Cardiol"
                        "fecha" => "1989"
                        "volumen" => "64"
                        "numero" => "8"
                        "paginaInicial" => "507"
                        "paginaFinal" => "512"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2773795"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/0002-9149(89)90430-x"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;0002-9149&#40;89&#41;90430-X"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Angio-RM das art&#233;rias car&#243;tidas e vertebrais&#58; an&#225;lise de diferentes t&#233;cnicas de volume e dilui&#231;&#227;o de contraste em aparelho de 1&#44;0 T e gradiente de 15 mT&#47;m&#42;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              LG Hartmann \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AM Wolosker \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              G D&#8217;Ippolito \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              ML Borri \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiol Bras"
                        "fecha" => "2001"
                        "volumen" => "34"
                        "numero" => "4"
                        "paginaInicial" => "201"
                        "paginaFinal" => "205"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1590&#47;S0100-39842001000400005"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aortic size assessment by noncontrast cardiac computed tomography&#58; normal limits by age&#44; gender&#44; and body surface area"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              A Wolak \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              H Gransar \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              LE Thomson \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              JD Friedman \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              R Hachamovitch \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              A Gutstein \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jcmg.2007.11.005"
                      "Revista" => array:7 [
                        "tituloSerie" => "JACC Cardiovasc Imaging"
                        "fecha" => "2008"
                        "volumen" => "1"
                        "numero" => "2"
                        "paginaInicial" => "200"
                        "paginaFinal" => "209"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19356429"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.jcmg.2007.11.005"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;jcmg&#46;2007&#46;11&#46;005"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of the thoracic aorta by multidetector computed tomography&#58; age- and sex-specific reference values in adults without evident cardiovascular disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              FY Lin \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RB Devereux \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              MJ Roman \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              J Meng \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              VM Jow \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              A Jacobs \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jcct.2008.08.002"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cardiovasc Comput Tomogr"
                        "fecha" => "2008"
                        "volumen" => "2"
                        "numero" => "5"
                        "paginaInicial" => "298"
                        "paginaFinal" => "308"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19083966"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.jcct.2008.08.002"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;jcct&#46;2008&#46;08&#46;002"
                      ]
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                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship of age&#44; gender&#44; race&#44; and body size to infrarenal aortic diameter&#46; The Aneurysm Detection and Management &#40;ADAM&#41; Veterans Affairs Cooperative Study Investigators"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              FA Lederle \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              GR Johnson \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              SE Wilson \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              IL Gordon \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              EP Chute \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              FN Littooy \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/s0741-5214(97)70057-0"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Vasc Surg"
                        "fecha" => "1997"
                        "volumen" => "26"
                        "numero" => "4"
                        "paginaInicial" => "595"
                        "paginaFinal" => "601"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9357459"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/s0741-5214(97)70057-0"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;S0741-5214&#40;97&#41;70057-0"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aortic aneurysm screening in a high-risk population&#58; a non-contrast computed tomography study in Korean males with hypertension"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              IJ Cho \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              SY Jang \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              HJ Chang \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              S Shin \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              CY Shim \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              GR Hong \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.4070/kcj.2014.44.3.162"
                      "Revista" => array:7 [
                        "tituloSerie" => "Korean Circ J"
                        "fecha" => "2014"
                        "volumen" => "44"
                        "numero" => "3"
                        "paginaInicial" => "162"
                        "paginaFinal" => "169"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24876857"
                            "web" => "Medline"
                          ]
                        ]
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                    ]
                    1 => array:2 [
                      "doi" => "10.4070/kcj.2014.44.3.162"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;4070&#47;kcj&#46;2014&#46;44&#46;3&#46;162"
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                  ]
                ]
              ]
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            15 => array:3 [
              "identificador" => "bib16"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Do Current Lung Cancer Screening Guidelines Apply for Populations With High Prevalence of Granulomatous Disease&#63; Results From the First Brazilian Lung Cancer Screening Trial &#40;BRELT1&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
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                            0 => """
                              RS dos Santos \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              JP Franceschini \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              RC Chate \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              MC Ghefter \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              F Kay \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              AL Trajano \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.athoracsur.2015.07.013"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "2016"
                        "volumen" => "101"
                        "numero" => "2"
                        "paginaInicial" => "481"
                        "paginaFinal" => "486"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26409711"
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                          ]
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                      "doi" => "10.1016/j.athoracsur.2015.07.013"
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                  ]
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              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Trends in aortic aneurysm- and dissection-related mortality in the state of S&#227;o Paulo&#44; Brazil&#44; 1985-2009&#58; multiple-cause-of-death analysis"
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                        0 => array:2 [
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                          "autores" => array:3 [
                            0 => """
                              AH Santo \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              P Puech-Le&#227;o \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M Krutman \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1186/1471-2458-12-859"
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                        "tituloSerie" => "BMC Public Health"
                        "fecha" => "2012"
                        "volumen" => "12"
                        "paginaInicial" => "859"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23046791"
                            "web" => "Medline"
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            17 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Normal thoracic aorta diameter on cardiac computed tomography in healthy asymptomatic adults&#58; impact of age and gender"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              SS Mao \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              N Ahmadi \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              B Shah \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              D Beckmann \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              A Chen \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              L Ngo \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.acra.2008.02.001"
                      "Revista" => array:7 [
                        "tituloSerie" => "Acad Radiol"
                        "fecha" => "2008"
                        "volumen" => "15"
                        "numero" => "7"
                        "paginaInicial" => "827"
                        "paginaFinal" => "834"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18572117"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.acra.2008.02.001"
                      "WWW" => array:1 [
                        "link" => "https&#58;&#47;&#47;doi&#46;org&#47;10&#46;1016&#47;j&#46;acra&#46;2008&#46;02&#46;001"
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                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diameters of the thoracic aorta throughout life as measured with helical computed tomography"
                      "autores" => array:1 [
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                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              A Hager \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              H Kaemmerer \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              U Rapp-Bernhardt \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              S Bl&#252;cher \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              K Rapp \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              TM Bernhardt \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
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                  ]
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                    0 => array:2 [
                      "doi" => "10.1067/mtc.2002.122310"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "2002"
                        "volumen" => "123"
                        "numero" => "6"
                        "paginaInicial" => "1060"
                        "paginaFinal" => "1066"
                        "link" => array:1 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Is aortic dilatation an atherosclerosis-related process&#63; Clinical&#44; laboratory&#44; and transesophageal echocardiographic correlates of thoracic aortic dimensions in the population with implications for thoracic aortic aneurysm formation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              Y Agmon \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              BK Khandheria \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              I Meissner \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              GL Schwartz \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JD Sicks \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              AJ Fought \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/s0735-1097(03)00922-7"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Am Coll Cardiol"
                        "fecha" => "2003"
                        "volumen" => "42"
                        "numero" => "6"
                        "paginaInicial" => "1076"
                        "paginaFinal" => "1083"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13678934"
                            "web" => "Medline"
                          ]
                        ]
                      ]
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                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Anatomical variations in branching pattern of arcus aorta&#58; 64-slice CTA appearance"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                              E Ergun \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              B &#350;im&#351;ek \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              PN Ko&#351;ar \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              BK Y&#305;lmaz \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              AT Turgut \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1007/s00276-012-1063-3"
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                        "tituloSerie" => "Surg Radiol Anat"
                        "fecha" => "2013"
                        "volumen" => "35"
                        "numero" => "6"
                        "paginaInicial" => "503"
                        "paginaFinal" => "509"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/23271166"
                            "web" => "Medline"
                          ]
                        ]
                      ]
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              ]
            ]
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              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Anatomical Variations in Aortic Arch Branching Pattern"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              B Jalali Kondori \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              MH Asadi \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              E Rahimian \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              MR Tahsini \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "0161901/AIM.0013"
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                        "tituloSerie" => "Arch Iran Med"
                        "fecha" => "2016"
                        "volumen" => "19"
                        "numero" => "1"
                        "paginaInicial" => "72"
                        "paginaFinal" => "74"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26702752"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prevalence of Bovine Aortic Arch Variant in Patients with Aortic Dissection and its Implications in the Outcome of Patients with Acute Type B Aortic Dissection"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              SN Mylonas \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Barkans \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M Ante \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              J Wippermann \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              D B&#246;ckler \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              JS Brunkwall \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ejvs.2017.12.005"
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur J Vasc Endovasc Surg"
                        "fecha" => "2018"
                        "volumen" => "55"
                        "numero" => "3"
                        "paginaInicial" => "385"
                        "paginaFinal" => "391"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/29338980"
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                          ]
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                ]
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              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Multimodality Noninvasive Imaging of Thoracic Aortic Aneurysms&#58; Time to Standardize&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              FP Mongeon \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              F Marcotte \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              DG Terrone \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.cjca.2015.09.025"
                      "Revista" => array:7 [
                        "tituloSerie" => "Can J Cardiol"
                        "fecha" => "2016"
                        "volumen" => "32"
                        "numero" => "1"
                        "paginaInicial" => "48"
                        "paginaFinal" => "59"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26724510"
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                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.cjca.2015.09.025"
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Article information

ISSN: 18075932
Original language: English

DOI:10.6061/clinics/2021/e2315

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	4	1	5
2024 October	61	34	95
2024 September	40	20	60
2024 August	49	32	81
2024 July	38	24	62
2024 June	27	15	42
2024 May	36	18	54
2024 April	40	14	54
2024 March	24	18	42
2024 February	29	9	38
2024 January	22	18	40
2023 December	21	24	45
2023 November	23	19	42
2023 October	24	28	52
2023 September	23	24	47
2023 August	39	5	44
2023 July	22	22	44
2023 June	26	6	32
2023 May	40	1	41
2023 April	32	2	34
2023 March	28	2	30
2023 February	16	1	17
2023 January	17	4	21
2022 December	16	3	19
2022 November	8	3	11

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