EDITORIAL
The influence of bitter-taste receptor (TAS2R) expression in pharmacological response to Chloroquine in obese patients with COVID-19
Read
920
Timeswas read the article
325
Total PDF
595
Total HTML
Share statistics
array:24 [ "pii" => "S1807593222004860" "issn" => "18075932" "doi" => "10.6061/clinics/2020/e2181" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "486" "copyright" => "CLINICS" "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by/4.0/" "subdocumento" => "edi" "cita" => "Clinics. 2020;75C:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S1807593222004872" "issn" => "18075932" "doi" => "10.6061/clinics/2020/e2183" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "487" "copyright" => "CLINICS" "documento" => "simple-article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by/4.0/" "subdocumento" => "edi" "cita" => "Clinics. 2020;75C:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:8 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">EDITORIAL</span>" "titulo" => "The interference of COVID-19 in the male reproductive system: Important questions and the future of assisted reproduction techniques" "tienePdf" => "en" "tieneTextoCompleto" => "en" "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Renata Cristina de Carvalho, Matheus Ferreira Groner, Jacqueline Camillo, Paulo Roberto Abrão Ferreira, Renato Fraietta" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Renata Cristina" "apellidos" => "de Carvalho" ] 1 => array:2 [ "nombre" => "Matheus Ferreira" "apellidos" => "Groner" ] 2 => array:2 [ "nombre" => "Jacqueline" "apellidos" => "Camillo" ] 3 => array:2 [ "nombre" => "Paulo Roberto Abrão" "apellidos" => "Ferreira" ] 4 => array:2 [ "nombre" => "Renato" "apellidos" => "Fraietta" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222004872?idApp=UINPBA00004N" "url" => "/18075932/000000750000000C/v1_202211290815/S1807593222004872/v1_202211290815/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1807593222004264" "issn" => "18075932" "doi" => "10.6061/clinics/2020/e2171" "estado" => "S300" "fechaPublicacion" => "2020-01-01" "aid" => "426" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by/4.0/" "subdocumento" => "dis" "cita" => "Clinics. 2020;75C:" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:9 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">COMMENTS</span>" "titulo" => "Virtual visits to inpatients by their loved ones during COVID-19" "tienePdf" => "en" "tieneTextoCompleto" => "en" "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 776 "Ancho" => 977 "Tamanyo" => 88910 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Virtual visit. Photo by Stela Murgel</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Izabel Cristina Rios, Ricardo Tavares de Carvalho, Vitor Maia Teles Ruffini, Amanda Cardoso Montal, Leila Suemi Harima, Douglas Henrique Crispim, Lilian Arai, Beatriz Perondi, Anna Miethke Morais, Andrea Janaina de Andrade, Eloisa Silva Dutra de Oliveira Bonfa" "autores" => array:11 [ 0 => array:2 [ "nombre" => "Izabel Cristina" "apellidos" => "Rios" ] 1 => array:2 [ "nombre" => "Ricardo Tavares de" "apellidos" => "Carvalho" ] 2 => array:2 [ "nombre" => "Vitor Maia Teles" "apellidos" => "Ruffini" ] 3 => array:2 [ "nombre" => "Amanda Cardoso" "apellidos" => "Montal" ] 4 => array:2 [ "nombre" => "Leila Suemi" "apellidos" => "Harima" ] 5 => array:2 [ "nombre" => "Douglas Henrique" "apellidos" => "Crispim" ] 6 => array:2 [ "nombre" => "Lilian" "apellidos" => "Arai" ] 7 => array:2 [ "nombre" => "Beatriz" "apellidos" => "Perondi" ] 8 => array:2 [ "nombre" => "Anna Miethke" "apellidos" => "Morais" ] 9 => array:2 [ "nombre" => "Andrea Janaina de" "apellidos" => "Andrade" ] 10 => array:2 [ "nombre" => "Eloisa Silva Dutra de Oliveira" "apellidos" => "Bonfa" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222004264?idApp=UINPBA00004N" "url" => "/18075932/000000750000000C/v1_202211290815/S1807593222004264/v1_202211290815/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">EDITORIAL</span>" "titulo" => "The influence of bitter-taste receptor (TAS2R) expression in pharmacological response to Chloroquine in obese patients with COVID-19" "tieneTextoCompleto" => true "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Lígia Moriguchi Watanabe, Izabella Ferreira Pires, Natália Yumi Noronha, Marcela Augusta de Souza Pinhel, Carla Barbosa Nonino" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Lígia Moriguchi" "apellidos" => "Watanabe" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] ] ] 1 => array:3 [ "nombre" => "Izabella Ferreira" "apellidos" => "Pires" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] ] ] 2 => array:3 [ "nombre" => "Natália Yumi" "apellidos" => "Noronha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Marcela Augusta de Souza" "apellidos" => "Pinhel" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">II</span>" "identificador" => "aff2" ] ] ] 4 => array:4 [ "nombre" => "Carla Barbosa" "apellidos" => "Nonino" "email" => array:1 [ 0 => "carla@fmrp.usp.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Departamento de Clinica Medica, Faculdade Medicina de Ribeirao Preto (FMRP), Universidade de Sao Paulo, Sao Paulo, SP, BR" "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Departamento de Biologia Molecular, Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), Sao Jose do Rio Preto, SP, BR" "etiqueta" => "II" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Corresponding author." ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1434 "Ancho" => 1499 "Tamanyo" => 186897 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">TAS2R molecular mechanisms in response to CQ and HCQ in obese patients on COVID-19 infection context.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="para10" class="elsevierStylePara elsevierViewall">The coronavirus disease 2019, referred to as COVID-19 by the World Health Organization (WHO), is an ongoing viral pandemic caused by the influenza-like virus strain SARS-CoV-2 (<a class="elsevierStyleCrossRef" href="#bib1">1</a>). According to WHO (2020), SARS-CoV-2 infection has been responsible for approximately 10,185,374 confirmed cases of COVID-19 and more than 500,000 deaths worldwide (<a class="elsevierStyleCrossRef" href="#bib2">2</a>). In Brazil, 1,368,195 cases have been confirmed, and 58,314 deaths have occurred as of June 30, 2020 (<a class="elsevierStyleCrossRef" href="#bib3">3</a>).</p><p id="para20" class="elsevierStylePara elsevierViewall">The coronaviruses are one of the primary pathogens that target the human respiratory system. These viruses often cause pneumonia-like symptoms that can develop into Severe Acute Respiratory Syndrome (SARS), causing higher leukocyte production, abnormal respiratory findings, and increased levels of plasma pro-inflammatory cytokines (<a class="elsevierStyleCrossRef" href="#bib4">4</a>). COVID-19 may manifest either as an asymptomatic infection or as a mild to severe pneumonia (<a class="elsevierStyleCrossRef" href="#bib5">5</a>). The most common initial symptoms at the onset of COVID-19 are fever, cough, and fatigue, while sputum production, headache, hemoptysis, diarrhea, dyspnea, and lymphopenia are less frequent (<a class="elsevierStyleCrossRef" href="#bib6">6</a>).</p><p id="para30" class="elsevierStylePara elsevierViewall">The severity of the COVID-19 infection varies among individuals and may relate to several reported risk factors, such as aging, diabetes mellitus, cardiovascular risk (including hypertension), and respiratory or kidney disease. Moreover, an increasing number of studies have linked obesity to more severe COVID-19 symptoms and, ultimately, increased mortality (<a class="elsevierStyleCrossRefs" href="#bib7">7–9</a>).</p><p id="para40" class="elsevierStylePara elsevierViewall">Recently, a retrospective analysis of 3,615 patients with COVID-19 at the New York academic hospital system reported that approximately 38% of these patients were obese (Body Mass Index, BMI >30 kg/m<span class="elsevierStyleSup">2</span>). Moreover, obese patients under 60 years of age had twofold susceptibility to being admitted in critical care compared to non-obese individuals (<a class="elsevierStyleCrossRef" href="#bib8">8</a>).</p><p id="para50" class="elsevierStylePara elsevierViewall">Obesity-related conditions worsen the impact of COVID-19 symptoms due to complications associated with excessive body weight, metabolic dysfunction, cardiovascular risk, sleep apnea, vitamin D deficiency, dysregulation of the renin-angiotensin-aldosterone system, and sarcopenia (<a class="elsevierStyleCrossRef" href="#bib10">10</a>). Furthermore, obese patients have altered levels of circulating cytokines. Notably, these individuals exhibit higher concentrations of TNF-alpha, MCP-1, and IL-6, which are generated by visceral and subcutaneous adipose tissue (<a class="elsevierStyleCrossRef" href="#bib11">11</a>). This alteration in inflammatory profile appears to predict the severity and prognosis of obese patients and COVID-19 (<a class="elsevierStyleCrossRef" href="#bib11">11</a>,<a class="elsevierStyleCrossRef" href="#bib12">12</a>). Thus, special attention should be considered for this population.</p><p id="para60" class="elsevierStylePara elsevierViewall">In the absence of efficient pharmacotherapy, and due to the public health emergency, a significant number of potential drugs was proposed, such as antiviral agents, chloroquine and hydroxychloroquine, and corticosteroids (<a class="elsevierStyleCrossRef" href="#bib13">13</a>,<a class="elsevierStyleCrossRef" href="#bib14">14</a>).</p><p id="para70" class="elsevierStylePara elsevierViewall">Chloroquine (CQ) is an amine acidotropic form of quinine. In the past, this compound was the drug of choice against malaria and has been reported to be a potential broad-spectrum antiviral drug (<a class="elsevierStyleCrossRef" href="#bib13">13</a>). The mechanism of action of CQ and its analog hydroxychloroquine (HCQ) consists in blocking viral entry into cells by interacting with viral particles that bind to human cell surface receptors (<a class="elsevierStyleCrossRef" href="#bib15">15</a>). Both CQ and HCQ can have immunomodulatory effects through the modulation of pro-inflammatory cytokines (<a class="elsevierStyleCrossRef" href="#bib13">13</a>).</p><p id="para80" class="elsevierStylePara elsevierViewall">CQ is also an active agonist of bitter-taste receptors (TAS2Rs), first identified in the bud cells of the tongue. These receptors signal information to the brain about the nutritive value or toxicity of ingested foods and beverages (<a class="elsevierStyleCrossRef" href="#bib16">16</a>,<a class="elsevierStyleCrossRef" href="#bib17">17</a>). Aside from their role in chemosensory cells, these receptors are expressed in an extensive range of tissues and perform varied functions (<a class="elsevierStyleCrossRef" href="#bib18">18</a>). A recent study conducted by Grassin-Delyle et al. (<a class="elsevierStyleCrossRef" href="#bib19">19</a>) suggested that TAS2Rs 3, 4, 5, 9, 10, 14, 30, 39, and 40 were involved in the inhibition of cytokine production. Moreover, Li et al. (<a class="elsevierStyleCrossRef" href="#bib12">12</a>) hypothesized that TAS2R10 might help to prevent the cytokine storm - a key event for patients with more aggressive COVID-19 symptoms - because its receptor regulates natural killer cell-mediated cytotoxicity, and chemokine, T-cell receptor, and TNF signaling pathways (<a class="elsevierStyleCrossRef" href="#bib12">12</a>). CQ binding to TAS2Rs may also result in functional changes in respiratory tract cells, such as smooth muscle, ciliated cells, and blood cell markers. This suggests that the extra-oral effects of CQ could be beneficial against pulmonary diseases (<a class="elsevierStyleCrossRef" href="#bib20">20</a>).</p><p id="para90" class="elsevierStylePara elsevierViewall">Interestingly, extra-oral TAS2R expression could be reduced in obese subjects compared to non-obese individuals (<a class="elsevierStyleCrossRef" href="#bib18">18</a>). This may result in a decreased sensitivity to bitter taste, which is often observed in obese individuals, and may affect food choices (<a class="elsevierStyleCrossRef" href="#bib18">18</a>). Considering the role of TAS2R and its agonists on immune responses, and the fact that CQ is a TAS2R agonist, we hypothesized that COVID-19-infected obese patients could respond differently to pharmacological treatment with CQ and side effects could occur more frequently due to overdosage in this population. This hypothesis is supported by a recent study that evaluated the risk of retinopathy - one of the most important long-term side effects of HCQ treatment - related to clinical characteristics and HCQ blood levels of 537 patients (<a class="elsevierStyleCrossRef" href="#bib21">21</a>). The authors found a significant association between higher BMI and a higher risk of HCQ toxicity, suggesting a limited HCQ dosage at 400 mg daily, irrespective of how high is the patient's BMI (<a class="elsevierStyleCrossRef" href="#bib21">21</a>).</p><p id="para100" class="elsevierStylePara elsevierViewall">Moreover, according to Karalis et al. (<a class="elsevierStyleCrossRef" href="#bib22">22</a>), dosage regimens of CQ/HCQ used for treating COVID-19 symtoms could be linked to high toxicity risk. Thus, to avoid adverse effects due to CQ/HCQ overdosage, the authors proposed dosage regimens tailored to the patient's characteristics, such as body weight, age, and severity of COVID-19 symptoms (<a class="elsevierStyleCrossRef" href="#bib22">22</a>). However, more studies are required to further address the influence of individual factors in the CQ/HCQ pharmacodynamics and the optimal dosage of CQ/HCQ for treating COVID-19 symptoms (<a class="elsevierStyleCrossRef" href="#bib15">15</a>,<a class="elsevierStyleCrossRef" href="#bib23">23</a>). <a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a> summarizes the association of TAS2R expression and the response to CQ and HCQ of obese patients in the context of COVID-19 infection.</p><elsevierMultimedia ident="fig1"></elsevierMultimedia><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">CONCLUSION</span><p id="para110" class="elsevierStylePara elsevierViewall">The COVID-19 pandemic is a significant global public health challenge, especially concerning the pursuit of effective drugs for its prevention and treatment. Considering the prevalence of obesity worldwide and the complications associated with excessive body mass ratio, special attention should be given to patients with obesity. In a condition of obesity, reduced TAS2R expression could affect the response to medications such as CQ. Altogether, we highlighted the importance of obese patient care, particularly during the current COVID-19 pandemic.</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">AUTHOR CONTRIBUTIONS</span><p id="para120" class="elsevierStylePara elsevierViewall">All of the authors participated in the discussion, and manuscript writing, review and approval of the final version.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "cesec10" "titulo" => "CONCLUSION" ] 1 => array:2 [ "identificador" => "cesec20" "titulo" => "AUTHOR CONTRIBUTIONS" ] 2 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2020-07-01" "fechaAceptado" => "2020-07-22" "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">No potential conflict of interest was reported.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1434 "Ancho" => 1499 "Tamanyo" => 186897 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">TAS2R molecular mechanisms in response to CQ and HCQ in obese patients on COVID-19 infection context.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ JF Chan \n \t\t\t\t\t\t\t\t """ 1 => """ KH Kok \n \t\t\t\t\t\t\t\t """ 2 => """ Z Zhu \n \t\t\t\t\t\t\t\t """ 3 => """ H Chu \n \t\t\t\t\t\t\t\t """ 4 => """ KK To \n \t\t\t\t\t\t\t\t """ 5 => """ S Yuan \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1080/22221751.2020.1719902" "Revista" => array:7 [ "tituloSerie" => "Emerg Microbes Infect" "fecha" => "2020" "volumen" => "9" "numero" => "1" "paginaInicial" => "221" "paginaFinal" => "236" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31987001" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1080/22221751.2020.1719902" "WWW" => array:1 [ "link" => "https://doi.org/10.1080/22221751.2020.1719902" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "WHO Coronavirus Disease (COVID-19) Dashboard" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ World Health Organization \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:1 [ "link" => "Available from: https://covid19.who.int/" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Painel Coronavírus. Painel Coronavírus" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ Ministério da Saúde Brazil \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:2 [ "link" => "Available from: https://covid.saude.gov.br/" "fecha" => "2020" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ HA Rothan \n \t\t\t\t\t\t\t\t """ 1 => """ SN Byrareddy \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "J Autoimmun" "fecha" => "2020" "volumen" => "109" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.jaut.2020.102433" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "COVID-19 (Novel Coronavirus 2019) - recent trends" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ S Kannan \n \t\t\t\t\t\t\t\t """ 1 => """ P Shaik Syed Ali \n \t\t\t\t\t\t\t\t """ 2 => """ A Sheeza \n \t\t\t\t\t\t\t\t """ 3 => """ K Hemalatha \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.26355/eurrev_202002_20378" "Revista" => array:7 [ "tituloSerie" => "Eur Rev Med Pharmacol Sci" "fecha" => "2020" "volumen" => "24" "numero" => "4" "paginaInicial" => "2006" "paginaFinal" => "2011" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32141569" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ C Huang \n \t\t\t\t\t\t\t\t """ 1 => """ Y Wang \n \t\t\t\t\t\t\t\t """ 2 => """ X Li \n \t\t\t\t\t\t\t\t """ 3 => """ L Ren \n \t\t\t\t\t\t\t\t """ 4 => """ J Zhao \n \t\t\t\t\t\t\t\t """ 5 => """ Y Hu \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(20)30183-5" "Revista" => array:7 [ "tituloSerie" => "Lancet" "fecha" => "2020" "volumen" => "395" "numero" => "10223" "paginaInicial" => "497" "paginaFinal" => "506" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31986264" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/S0140-6736(20)30183-5" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/S0140-6736(20)30183-5" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ CM Petrilli \n \t\t\t\t\t\t\t\t """ 1 => """ SA Jones \n \t\t\t\t\t\t\t\t """ 2 => """ J Yang \n \t\t\t\t\t\t\t\t """ 3 => """ H Rajagopalan \n \t\t\t\t\t\t\t\t """ 4 => """ L O'Donnell \n \t\t\t\t\t\t\t\t """ 5 => """ Y Chernyak \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1136/bmj.m1966" "Revista" => array:5 [ "tituloSerie" => "BMJ" "fecha" => "2020" "volumen" => "369" "paginaInicial" => "m1966" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32444366" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1136/bmj.m1966" "WWW" => array:1 [ "link" => "https://doi.org/10.1016/10.1136/bmj.m1966" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Predictors of Refractory Coronavirus Disease (COVID-19) Pneumonia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ B Abu-Raya \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1093/cid/ciaa409" "Revista" => array:7 [ "tituloSerie" => "Clin Infect Dis" "fecha" => "2020" "volumen" => "71" "numero" => "15" "paginaInicial" => "895" "paginaFinal" => "896" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32271373" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1093/cid/ciaa409" "WWW" => array:1 [ "link" => "https://doi.org/10.1093/cid/ciaa409" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ G Onder \n \t\t\t\t\t\t\t\t """ 1 => """ G Rezza \n \t\t\t\t\t\t\t\t """ 2 => """ S Brusaferro \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "JAMA" "fecha" => "2020" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1001/jama.2020.4683" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "COVID and the Renin-Angiotensin System: Are Hypertension or Its Treatments Deleterious?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ F Zores \n \t\t\t\t\t\t\t\t """ 1 => """ ME Rebeaud \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.3389/fcvm.2020.00071" "Revista" => array:5 [ "tituloSerie" => "Front Cardiovasc Med" "fecha" => "2020" "volumen" => "7" "paginaInicial" => "71" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32391384" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.3389/fcvm.2020.00071" "WWW" => array:1 [ "link" => "https://doi.org/10.3389/fcvm.2020.00071" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fat mass prevalence and influence on nutritional status in ICU COVID-19 patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ De Lorenzo A \n \t\t\t\t\t\t\t\t """ 1 => """ M Tarsitano \n \t\t\t\t\t\t\t\t """ 2 => """ C Falcone \n \t\t\t\t\t\t\t\t """ 3 => """ L Renzo \n \t\t\t\t\t\t\t\t """ 4 => """ L Romano \n \t\t\t\t\t\t\t\t """ 5 => """ S Macheda \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:2 [ "link" => "https://doi.org/10.21203/rs.3.rs-33974/v1" "fecha" => "2020" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Existing bitter medicines for fighting 2019-nCoV-associated infectious diseases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ X Li \n \t\t\t\t\t\t\t\t """ 1 => """ C Zhang \n \t\t\t\t\t\t\t\t """ 2 => """ L Liu \n \t\t\t\t\t\t\t\t """ 3 => """ M Gu \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1096/fj.202000502" "Revista" => array:7 [ "tituloSerie" => "FASEB J" "fecha" => "2020" "volumen" => "34" "numero" => "5" "paginaInicial" => "6008" "paginaFinal" => "6016" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32281695" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1096/fj.202000502" "WWW" => array:1 [ "link" => "https://doi.org/10.1096/fj.202000502" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ CA Devaux \n \t\t\t\t\t\t\t\t """ 1 => """ JM Rolain \n \t\t\t\t\t\t\t\t """ 2 => """ P Colson \n \t\t\t\t\t\t\t\t """ 3 => """ D Raoult \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Int J Antimicrob Agents" "fecha" => "2020" "volumen" => "55" "numero" => "5" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.ijantimicag.2020.105938" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ M Wang \n \t\t\t\t\t\t\t\t """ 1 => """ R Cao \n \t\t\t\t\t\t\t\t """ 2 => """ L Zhang \n \t\t\t\t\t\t\t\t """ 3 => """ X Yang \n \t\t\t\t\t\t\t\t """ 4 => """ J Liu \n \t\t\t\t\t\t\t\t """ 5 => """ M Xu \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1038/s41422-020-0282-0" "Revista" => array:7 [ "tituloSerie" => "Cell Res" "fecha" => "2020" "volumen" => "30" "numero" => "3" "paginaInicial" => "269" "paginaFinal" => "271" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32020029" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1038/s41422-020-0282-0" "WWW" => array:1 [ "link" => "https://doi.org/10.1038/s41422-020-0282-0" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The epidemiology, diagnosis and treatment of COVID-19" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ P Zhai \n \t\t\t\t\t\t\t\t """ 1 => """ Y Ding \n \t\t\t\t\t\t\t\t """ 2 => """ X Wu \n \t\t\t\t\t\t\t\t """ 3 => """ J Long \n \t\t\t\t\t\t\t\t """ 4 => """ Y Zhong \n \t\t\t\t\t\t\t\t """ 5 => """ Y Li \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Int J Antimicrob Agents" "fecha" => "2020" "volumen" => "55" "numero" => "5" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.ijantimicag.2020.105955" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extraoral bitter taste receptors in health and disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ P Lu \n \t\t\t\t\t\t\t\t """ 1 => """ CH Zhang \n \t\t\t\t\t\t\t\t """ 2 => """ LM Lifshitz \n \t\t\t\t\t\t\t\t """ 3 => """ R ZhuGe \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1085/jgp.201611637" "Revista" => array:7 [ "tituloSerie" => "J Gen Physiol" "fecha" => "2017" "volumen" => "149" "numero" => "2" "paginaInicial" => "181" "paginaFinal" => "197" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28053191" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1085/jgp.201611637" "WWW" => array:1 [ "link" => "https://doi.org/10.1085/jgp.201611637" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Taste receptors in innate immunity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ RJ Lee \n \t\t\t\t\t\t\t\t """ 1 => """ NA Cohen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s00018-014-1736-7" "Revista" => array:7 [ "tituloSerie" => "Cell Mol Life Sci" "fecha" => "2015" "volumen" => "72" "numero" => "2" "paginaInicial" => "217" "paginaFinal" => "236" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25323130" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s00018-014-1736-7" "WWW" => array:1 [ "link" => "https://doi.org/10.1007/s00018-014-1736-7" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extra-oral bitter taste receptors: New targets against obesity?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ Q Wang \n \t\t\t\t\t\t\t\t """ 1 => """ KI Liszt \n \t\t\t\t\t\t\t\t """ 2 => """ I Depoortere \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Peptides" "fecha" => "2020" "volumen" => "127" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.peptides.2020.170284" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bitter Taste Receptors (TAS2Rs) in Human Lung Macrophages: Receptor Expression and Inhibitory Effects of TAS2R Agonists" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ S Grassin-Delyle \n \t\t\t\t\t\t\t\t """ 1 => """ H Salvator \n \t\t\t\t\t\t\t\t """ 2 => """ N Mantov \n \t\t\t\t\t\t\t\t """ 3 => """ C Abrial \n \t\t\t\t\t\t\t\t """ 4 => """ M Brollo \n \t\t\t\t\t\t\t\t """ 5 => """ C Faisy \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Front Physiol" "fecha" => "2019" "volumen" => "10" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.3389/fphys.2019.01267" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bitter Taste Receptors for Asthma Therapeutics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ AP Nayak \n \t\t\t\t\t\t\t\t """ 1 => """ SD Shah \n \t\t\t\t\t\t\t\t """ 2 => """ JV Michael \n \t\t\t\t\t\t\t\t """ 3 => """ DA Deshpande \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.3389/fphys.2019.00884" "Revista" => array:5 [ "tituloSerie" => "Front Physiol" "fecha" => "2019" "volumen" => "10" "paginaInicial" => "884" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31379597" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.3389/fphys.2019.00884" "WWW" => array:1 [ "link" => "https://doi.org/10.3389/fphys.2019.00884" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hydroxychloroquine Blood Levels Predict Hydroxychloroquine Retinopathy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ M Petri \n \t\t\t\t\t\t\t\t """ 1 => """ M Elkhalifa \n \t\t\t\t\t\t\t\t """ 2 => """ J Li \n \t\t\t\t\t\t\t\t """ 3 => """ LS Magder \n \t\t\t\t\t\t\t\t """ 4 => """ DW Goldman \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1002/art.41121" "Revista" => array:7 [ "tituloSerie" => "Arthritis Rheumatol" "fecha" => "2020" "volumen" => "72" "numero" => "3" "paginaInicial" => "448" "paginaFinal" => "453" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/31532077" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1002/art.41121" "WWW" => array:1 [ "link" => "https://doi.org/10.1002/art.41121" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chloroquine dosage regimens in patients with COVID-19: Safety risks and optimization using simulations" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ V Karalis \n \t\t\t\t\t\t\t\t """ 1 => """ G Ismailos \n \t\t\t\t\t\t\t\t """ 2 => """ E Karatza \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:3 [ "tituloSerie" => "Saf Sci" "fecha" => "2020" "volumen" => "129" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/j.ssci.2020.104842" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chloroquine for SARS-CoV-2: Implications of Its Unique Pharmacokinetic and Safety Properties" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ C Smit \n \t\t\t\t\t\t\t\t """ 1 => """ MYM Peeters \n \t\t\t\t\t\t\t\t """ 2 => """ JN van den Anker \n \t\t\t\t\t\t\t\t """ 3 => """ CAJ Knibbe \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s40262-020-00891-1" "Revista" => array:7 [ "tituloSerie" => "Clin Pharmacokinet" "fecha" => "2020" "volumen" => "59" "numero" => "6" "paginaInicial" => "659" "paginaFinal" => "669" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32306288" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s40262-020-00891-1" "WWW" => array:1 [ "link" => "https://doi.org/10.1007/s40262-020-00891-1" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/000000750000000C/v1_202211290815/S1807593222004860/v1_202211290815/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/000000750000000C/v1_202211290815/S1807593222004860/v1_202211290815/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222004860?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 5 | 2 | 7 |
| 2024 October | 41 | 25 | 66 |
| 2024 September | 39 | 29 | 68 |
| 2024 August | 53 | 18 | 71 |
| 2024 July | 26 | 25 | 51 |
| 2024 June | 20 | 13 | 33 |
| 2024 May | 28 | 13 | 41 |
| 2024 April | 23 | 11 | 34 |
| 2024 March | 29 | 12 | 41 |
| 2024 February | 41 | 17 | 58 |
| 2024 January | 26 | 18 | 44 |
| 2023 December | 15 | 17 | 32 |
| 2023 November | 17 | 16 | 33 |
| 2023 October | 18 | 32 | 50 |
| 2023 September | 13 | 24 | 37 |
| 2023 August | 20 | 3 | 23 |
| 2023 July | 10 | 22 | 32 |
| 2023 June | 21 | 5 | 26 |
| 2023 May | 36 | 3 | 39 |
| 2023 April | 36 | 1 | 37 |
| 2023 March | 33 | 4 | 37 |
| 2023 February | 24 | 3 | 27 |
| 2023 January | 6 | 4 | 10 |
| 2022 December | 14 | 8 | 22 |
| 2022 November | 1 | 0 | 1 |
Show all