Immunohistochemical analysis of the neural structures of the posterior cruciate ligament in osteoarthritis patients submitted to total knee arthroplasty: an analysis of thirty-four cases

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"etiqueta" => "I" "identificador" => "af1-cln_70p81" ] 1 => array:3 [ "entidad" => "Hospital Federal de Ipanema, Department of Orthopedics and Traumatology, Rio de Janeiro/RJ, Brazil." "etiqueta" => "II" "identificador" => "af2-cln_70p81" ] 2 => array:3 [ "entidad" => "Faculdade de Medicina da Universidade do Estado do Rio de Janeiro (UERJ), Department of Histology, Rio de Janeiro/RJ, Brazil." "etiqueta" => "III" "identificador" => "af3-cln_70p81" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig3-cln_70p81" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 443 "Ancho" => 590 "Tamanyo" => 92854 ] ] "descripcion" => array:1 [ "en" => "Gomori trichrome stain (40× magnification). Neurovascular bundle presenting a thickened vascular tunica intima (thin black arrow), duplication of elastic fibers (thick black arrow) and nerve atrophy." ] ] ] "textoCompleto" => "INTRODUCTIONTotal knee arthroplasty has been demonstrated to be extremely efficient in the treatment of advanced osteoarthrosis of this joint (<a class="elsevierStyleCrossRef" href="#bib1">1</a>).Currently, there are two main arthroplasty techniques, which involve either preservation or replacement of the posterior cruciate ligament (PCL). Both techniques have yielded consistent functional results (<a class="elsevierStyleCrossRef" href="#bib1">1</a>).The choice of the most suitable implant has generated controversy. Advocates of the use of a prosthesis to preserve the PCL allege that this would ensure an increased range of motion, better stair-climbing performance and enhanced proprioception (<a class="elsevierStyleCrossRef" href="#bib2">2</a>,<a class="elsevierStyleCrossRef" href="#bib3">3</a>).An innovative study performed by Kennedy et al. (<a class="elsevierStyleCrossRef" href="#bib4">4</a>) in 1982 revealed the presence of nerve fibers and mechanoreceptors in anterior and posterior cruciate ligaments, menisci and capsular structures, indicating that these structures may be related to proprioception. These authors also described a nerve bundle in the synovium surrounding the PCL that is supposedly continuous with the tibial nerve and that carries nerve impulses.In subsequent studies, Franchi et al. (<a class="elsevierStyleCrossRef" href="#bib5">5</a>) and Del Valle et al. (<a class="elsevierStyleCrossRef" href="#bib6">6</a>) recognized Ruffini and Pacini receptors, Golgi endings and nerve fiber terminals in the PCL of osteoarthritis patients submitted to prosthetic knee replacement.To achieve adequate biomechanical performance, a knee prosthesis needs PCL preservation to ensure sufficient conservation of the anatomical and functional structures (<a class="elsevierStyleCrossRef" href="#bib7">7</a>,<a class="elsevierStyleCrossRef" href="#bib8">8</a>). Similarly, it is necessary for the nerve endings and neuroreceptors to remain present and functional to ensure that the proprioceptive properties of the retained PCL are maintained (<a class="elsevierStyleCrossRef" href="#bib5">5</a>).An analysis of PCL innervation in patients with advanced arthrosis is likely to be important in clinical practice, as the presence of neuroreceptors remaining in the ligament would be a sign that this ligament should be preserved for proprioception purposes (<a class="elsevierStyleCrossRef" href="#bib6">6</a>). Along the same line of reasoning, if we can establish a subgroup of patients with particular clinical and/or radiological parameters in whom PCL innervation is seriously impaired, a posterior-stabilized prosthesis, which would require the ligament to be sacrificed, could be considered. These data may provide additional evidence that may be used to determine the most suitable type of implant for a particular patient.MATERIALS AND METHODSA cross-sectional study in which 31 patients (34 ligaments) were evaluated was conducted. Of these patients, 22 were female and 9 were male. The patients' age ranged from 53 to 87 years and they were submitted to arthroplasty with PCL replacement at our service between June 2009 and June 2011.This research complied with the Declaration of Helsinki and was approved by the Ethics Committee of Universidade de São Paulo (USP).Only cases of primary osteoarthritis were included in this series; patients with rheumatic diseases and patients who underwent osteosynthesis surgery, osteotomy or previous arthrotomy at the knee level and posttraumatic sequelae were excluded.The patients who participated in this survey signed an informed consent form declaring their awareness of the methodology and objectives of this study.The PCL was sectioned at its femoral origin during surgery and its tibial bone insertion was maintained. This ligament was removed after tibial sectioning was performed.The PCL was preserved in 10% formaldehyde and was subsequently placed in a paraffin mold such that the ligament fibers were oriented along the longitudinal axis. The paraffin blocks were then sectioned and stained with hematoxylin-eosin.For Gomori trichrome staining, the paraffin mold was soaked in this reagent. Gomori trichrome staining is an excellent technique for ligament analysis, as this reagent stains whole or new collagen fibers green, aged collagen fibers red and cell nuclei purplish-blue (hematoxylin) (<a class="elsevierStyleCrossRef" href="#bib9">9</a>).For immunohistochemical analysis, paraffin sections measuring approximately 10 µm were processed in streptavidin-biotin-peroxidase and incubated with anti-S100 protein antibodies. In the axonal neurofilament experiments, the process was similar; however, the processed mold was instead placed in contact with anti-neurofilament antibodies.The S100 protein is found in the Schwann cells and myelinated fibers present in mechanoreceptors. The anti-neurofilament antibody labels the cytoskeleton (axon).Histological degeneration of the collagen fibers of the ligament was analyzed using optical microscopy (OM) and was classified as follows (<a class="elsevierStyleCrossRef" href="#bib7">7</a>):<ul class="elsevierStyleList" id="celist10"><li class="elsevierStyleListItem" id="celistitem10">a.Mild: defined by impairment of fewer than 20% of the collagen fibers based on an examination of 10 fields at 100× magnification. The predominant findings were disorganized collagen bundles in certain areas (fields of the slide) and an increase in slack connective tissue between the bundles.</li><li class="elsevierStyleListItem" id="celistitem20">b.Moderate: defined by impairment of at least 20% but less than 50% of the collagen fibers. Based on microscopic examination, the predominant alterations were an inflammatory reaction; hypercellularity; increased vascularization and disorganized, frayed or dense collagen bundles in several places.</li><li class="elsevierStyleListItem" id="celistitem30">c.Severe: defined by the involvement of more than 50% of the collagen fibers in the bundles based on the evaluation of 10 fields at 100× magnification. The predominant alterations observed by OM were the presence of cysts, collagen degeneration (fibrinoid/mucoid/myxoid) and intratendon fatty infiltration, with the possibility of total loss of the structure and integrity of the collagen fiber bundles (coalescent fields) (<a class="elsevierStyleCrossRef" href="#fig1-cln_70p81">Figure1</a>).<elsevierMultimedia ident="fig1-cln_70p81"></elsevierMultimedia></li></ul>The neural immunomarking of specific corpuscles and of neurofilaments was qualitatively assessed and classified as the presence or absence of marking.The mechanoreceptors were classified into four types according to the classification established by Freeman and Wyke (<a class="elsevierStyleCrossRef" href="#bib10">10</a>) (<a class="elsevierStyleCrossRef" href="#fig2-cln_70p81">Figure2</a>):<ul class="elsevierStyleList" id="celist20"><li class="elsevierStyleListItem" id="celistitem40">•Type I (Ruffini): encapsulated ovoid or globular corpuscles with slow adaptation function.</li><li class="elsevierStyleListItem" id="celistitem50">•Type II (Pacini): elongated conical corpuscles with fast adaptation function.</li><li class="elsevierStyleListItem" id="celistitem60">•Type III (Golgi): spindle-shaped corpuscles with fast adaptation function.</li><li class="elsevierStyleListItem" id="celistitem70">•Type IV: non-corpuscular endings that can be free (pain) or efferent and amyelinic (vasomotricity).</li></ul><elsevierMultimedia ident="fig2-cln_70p81"></elsevierMultimedia>The Ahlbäck classification was used to classify the radiological pattern of arthrosis into five types (<a class="elsevierStyleCrossRef" href="#bib11">11</a>).Measurement of the tibiofemoral angulation involved knee radiographs taken with orthostatic support encompassing the distal femoral and proximal tibial diaphysis. A goniometer was used to measure the tibiofemoral angle, which consisted of the intersection of the femoral and tibial anatomical axes. The following angles were considered: varus (less than or equal to 4° of the tibiofemoral valgus), neutral (from 5° to 9° of the valgus) and valgus (above 10°).The radiological parameters (the Ahlbäck classification and the measurement of the tibiofemoral axis) were evaluated together by two specialist surgeons with more than 10 years of experience in arthroplasty surgery. In case of discordance, a third colleague with the same training assisted in determining the end result.The patients were divided into two age groups: 70 years and over and under 70 years.Based on macroscopic analysis at the time of surgery, the anterior cruciate ligament (ACL) was considered either present or absent. No attempt was made to classify the ACL as normal or undergoing macroscopic degeneration, as this would generate a bias in the analysis due to extreme subjectivity.The neurovascular bundle (NVB) was classified as preserved, degenerated or absent. In the degenerated cases, the following characteristics were observed by microscopy: a thickened tunica intima in the vessels, degeneration in the elastic laminae of the vascular wall and nerve atrophy demonstrated by perineural retraction (<a class="elsevierStyleCrossRef" href="#fig3-cln_70p81">Figure3</a>). In the cases classified as absent, the NVB was not visualized. This absence of visualization can be interpreted in two ways: either the NVB was not included in the histological section, or it was not present. The four absent cases were excluded from the statistical analysis due to these two distinct possibilities.<elsevierMultimedia ident="fig3-cln_70p81"></elsevierMultimedia>The presence of neural structures in the PCL was evaluated and correlated with the tibiofemoral angulation (varus-valgus), the degree of histological degeneration of the collagen fibers, the macroscopic state of the ACL, Ahlbäck's radiological classification, age, sex and the histological state of the NVB contained in the synovium that surrounds the PCL. The histological pattern of the vascular bundle (preserved or degenerated) was also correlated with previously described parameters.Statistical analysisThe chi-square test was used for analysis of parametric data and the Kruskal-Wallis test and Mann-Whitney test were used for analysis of non-parametric data. Values of p<0.05 were considered significant. Fisher's exact test was used for analysis of categorical data.RESULTSRegarding the grade of histological degeneration, there were 23 severe cases (67.5%), 9 moderate cases (26.5%) and 2 mild cases (6%).According to Ahlbäck's radiological classification of arthrosis, there were seven grade I (20.5%), five grade II (14.5%), 14 grade III (41%), six grade IV (18%) and two grade V (6%) cases.There were six cases of genu valgum (17.5%), 2 neutral cases (6%) and 26 cases of genu varum (76.5%).The ACL was present in 64.7% of cases (22 cases) and absent in 35.3% of cases (12 cases).The NVB contained in the synovium of the PCL was identified in 30 cases (88.5%), whereas it appeared degenerated in 22 cases (65%) (<a class="elsevierStyleCrossRef" href="#fig3-cln_70p81">Figure3</a>) and preserved in eight cases (23.5%). Additionally, in 4 cases, the NVB could not be identified in the histological sections (11.5%).Immunomarking for neural structures was positive in 23 of the cases (67.5%). Specific mechanoreceptors were identified in 10 ligaments, with 9 type II cases (Pacini) and six type IV cases predominating. Moreover, neurofilaments were identified in 14 ligaments.Neural immunomarking was more frequent in the genu varum (77%) than in the genu valgum (50%); this difference was statistically significant, as demonstrated by the chi-square test (p = 0.048) (<a class="elsevierStyleCrossRef" href="#t1-cln_70p81">Table1</a>).<elsevierMultimedia ident="t1-cln_70p81"></elsevierMultimedia>Immunomarking positivity was observed even at increasing levels of the Ahlbäck classification (p = 0.277).A significant correlation was demonstrated between severe histological degeneration of the PCL and degeneration of the NVB (Mann-Whitney test, p = 0.015) (<a class="elsevierStyleCrossRef" href="#t2-cln_70p81">Table2</a>). Considering the 30 cases in which the NVB was identified, in the event of severe degeneration of the PCL, the NVB was degenerated 85.7% of the time (18/21 cases). In the cases with mild or moderate histological impairment of the PCL, the NVB was degenerated 44% of the time (4/9 cases).<elsevierMultimedia ident="t2-cln_70p81"></elsevierMultimedia>There was no significant relationship between the immunomarking of the neural structures or the pattern of degeneration of the NVB and the other parameters studied (<a class="elsevierStyleCrossRef" href="#t1-cln_70p81">Tables1</a>) and <a class="elsevierStyleCrossRef" href="#t2-cln_70p81">2</a>).DISCUSSIONThe functional integrity of the PCL is essential for the functionality of the knee prosthesis in which this ligament is preserved. The preservation of this structure, at least in theory, could benefit proprioception (<a class="elsevierStyleCrossRef" href="#bib6">6</a>).In 1982, Kennedy et al. (<a class="elsevierStyleCrossRef" href="#bib4">4</a>) performed experiments that were based on a study by Gardiner (<a class="elsevierStyleCrossRef" href="#bib12">12</a>) and demonstrated that the tibial nerve is the source of the nerve fibers that innervate the synovium that surrounds the cruciate ligaments. Using the silver nitrate impregnation technique, these authors detected the presence of superficial axons and Golgi receptors in the PCL synovium.In 1984, Schultz et al. (<a class="elsevierStyleCrossRef" href="#bib13">13</a>) used a similar technique and also described the presence of several unmyelinated axons in the peripheral fat (synovium) that coats the cruciate ligaments, in addition to significant degeneration of the collagen fibers of these ligaments. In 22 cruciate ligaments, they observed only 1 mechanoreceptor.Studies conducted by Franchi et al. (<a class="elsevierStyleCrossRef" href="#bib5">5</a>) and Dell Valle et al. (<a class="elsevierStyleCrossRef" href="#bib6">6</a>) revealed that neural structures and mechanoreceptors were present in the PCL of patients with arthrosis submitted to knee arthroplasty, even in the presence of degeneration of the ligament's collagen fibers. In fact, Franchi et al. (<a class="elsevierStyleCrossRef" href="#bib5">5</a>) observed a decrease in the number of mechanoreceptors in the arthritic knee. Both groups of investigators, however, failed to determine either the histological grade of PCL degeneration or the radiological grade of the associated arthrosis.Proprioception is the ability to detect movement and positioning in the space of a particular joint and is performed by neural receptors located within the joint capsule in the ligaments, muscles and skin (<a class="elsevierStyleCrossRef" href="#bib14">14</a>).In studies conducted by Barret et al. (<a class="elsevierStyleCrossRef" href="#bib2">2</a>) and Skinner (<a class="elsevierStyleCrossRef" href="#bib15">15</a>), the authors found that proprioception diminishes with age and that proprioception in cases of knee osteoarthritis differs from that in control individuals of the same age. Disorganization of the collagen fibers of the PCL supposedly leads to greater lassitude of this ligament. This process could raise the threshold of response in the nerve fibers and mechanoreceptors located along the axis of the pathologically slackened ligament. Moreover, the function of the afferent neural structures present in the PCL could be impaired, either due to a decrease in their number or due to their degeneration.Several studies (<a class="elsevierStyleCrossRefs" href="#bib15">15-17</a>) have not described proprioception differences between patients who received a PCL replacement prosthesis and those with preservation of this ligament.Regarding mechanoreceptors, Pacinian corpuscles predominated in the present study, in accordance with studies by Franchi et al. (<a class="elsevierStyleCrossRef" href="#bib5">5</a>) and Katonis et al. (<a class="elsevierStyleCrossRef" href="#bib18">18</a>), whereas no Golgi receptors were found. These results are consistent with the work of Dell Valle et al. (<a class="elsevierStyleCrossRef" href="#bib6">6</a>), who did not observe this type of mechanoreceptor in humans.In our study, in most cases (67.5%), neural structures were present in the PCL, even in the presence of severe degeneration. These data are in accordance with the work of Nelissen and Hogendoorn (<a class="elsevierStyleCrossRef" href="#bib8">8</a>), who examined a series of 11 knee arthrosis patients and observed eight cases of severe degeneration of the PCL. In seven of these cases, neural structures were present in the ligament.In the current study, mechanoreceptors and neurofilaments were mostly present in the individuals with advanced grades of arthrosis, as determined using Ahlbäck's radiological classification (IV and V). In contrast, in the study by Nelissen and Hogendoorn (<a class="elsevierStyleCrossRef" href="#bib8">8</a>), in which only Ahlbäck type IV and V cases were considered, neural structures were identified in all but one case.Positive immunomarking was significantly more likely to be observed in cases of genu varum (77%) than in cases of genu valgum (50%) in the present study. Although statistical significance could not be determined due to the small size of the study group, all six cases of genu valgum presented severe histological degeneration of the PCL. Such findings support the practice of sacrificing the PCL in cases of genu valgum, which has been reported by certain authors (<a class="elsevierStyleCrossRef" href="#bib19">19</a>). Cases of genu valgum are usually more technically demanding than those of genu varum (<a class="elsevierStyleCrossRef" href="#bib19">19</a>). In particular, ligament release is more complex and sacrificing the PCL facilitates better ligament balance in the knee. Moreover, if the proprioceptive capacity of this ligament is more severely impaired in cases of valgus, a posterior-stabilized prosthesis in which the PCL ligament is discarded would be more suitable based on this hypothesis.In our study, 30/34 of PCL specimens (88%), it was possible to identify the subsynovial NVB described previously by Kennedy et al. (<a class="elsevierStyleCrossRef" href="#bib4">4</a>) and Schultz et al. (<a class="elsevierStyleCrossRef" href="#bib13">13</a>). In 22 cases (64.7%), degeneration of this bundle could be observed by microscopy. Our data are consistent with those of Stubbs et al. (<a class="elsevierStyleCrossRef" href="#bib20">20</a>), who examined 50 PCLs from arthrosis patients submitted to arthroplasty and found arteriosclerosis and perineural fibrosis in 78% and 50% of the ligaments studied, respectively, after histological analysis.Degenerative alterations of the NVB could lead to impaired function and decreased transmission of impulses captured in the knee. This degeneration of the subsynovial NVB should be studied in more depth, as it could be, at least in theory, one of the factors responsible for the proprioception deficit of arthritic patients.A significant statistical correlation (p = 0.015) was identified between the grade of PCL degeneration and the state of the NVB in the current study. The cases of severe histological degeneration of the PCL were related to degenerated NVBs 80% of the time and to impaired bundles 44% of the time in cases of mild or moderate degeneration. These data are important because if we can identify patients with severe PCL degeneration, aside from altered biomechanical properties, this may be an indicator of deficient proprioception in the ligament. Under this potential set of circumstances, PCL replacement arthroplasty would, in theory, be an indication to consider.The good results obtained with prostheses with preservation of the PCL, despite advanced degeneration in many cases, could be due to the design of the implants; the ligament plays a secondary role when applying an axial load to the prosthesis (<a class="elsevierStyleCrossRef" href="#bib20">20</a>). In addition, after arthroplasty, the collateral ligaments and the capsule are responsible for knee proprioception, which helps to explain the similar results obtained using prostheses with and without sacrifice of the PCL (<a class="elsevierStyleCrossRef" href="#bib20">20</a>).This study has certain limitations. The first is that the immunomarking analysis was merely qualitative; thus, the density of the ligament innervation was not quantified. Another weak point is the use of Ahlbäck's radiological classification, which has limited reproducibility (<a class="elsevierStyleCrossRef" href="#bib21">21</a>); however, it is the most widely used classification system among orthopedic surgeons. The method by which the grade of histological PCL degeneration was evaluated was also subjective, although this method was based on previous studies (<a class="elsevierStyleCrossRef" href="#bib7">7</a>,<a class="elsevierStyleCrossRef" href="#bib20">20</a>,<a class="elsevierStyleCrossRef" href="#bib22">22</a>) and conducted by a histologist with extensive experience in scientific studies. One strong point of the study is that it was performed in patients submitted to surgery in whom neural structures were identified using one of the most widely accepted current techniques: immunomarking for S100 and neurofilaments. Furthermore, we demonstrated the relationship between severe degeneration of the PCL and impairment of the NVB. We also established that neural structures are more commonly present in cases of varus deformity than in cases of valgus deformity. These original results pave the way for the development of new questions. Additionally, the results should inspire surveys geared toward the identification of epidemiological, clinical and radiological parameters that may be related to the histological and functional states of the PCL and its applications in surgical practice.The topic of articular mechanoreceptors is far from being merely academic, as it has served as one of the foundations of prestigious authors (<a class="elsevierStyleCrossRef" href="#bib1">1</a>,<a class="elsevierStyleCrossRef" href="#bib6">6</a>) recommendation of PCL preservation in knee arthroplasty. Additionally, articular mechanoreceptors have been the subject of recent surveys on other joints, such as the shoulder (<a class="elsevierStyleCrossRef" href="#bib15">15</a>) and intervertebral disc (<a class="elsevierStyleCrossRef" href="#bib23">23</a>).CONCLUSION1) Intrinsic neural structures were detected in the majority of the PCLs of patients submitted to knee arthroplasty for osteoarthritis, even in the presence of severe structural degeneration of the ligament's collagen fibers. 2) There was an association between severe PCL degeneration and NVB compromise. 3) Neural structures were more frequently observed in varus knees than in valgus knees.AUTHOR CONTRIBUTIONSMartins GC conceived the study, harvested the ligaments, the data and wrote the manuscript. Camanho GL analyzed the data and revised the manuscript. Rodrigues MI performed the histological analysis." "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xpalclavsec1581482" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "MATERIALS AND METHODS" "secciones" => array:1 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Statistical analysis" ] ] ] 3 => array:2 [ "identificador" => "cesec40" "titulo" => "RESULTS" ] 4 => array:2 [ "identificador" => "cesec50" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec60" "titulo" => "CONCLUSION" ] 6 => array:2 [ "identificador" => "cesec70" "titulo" => "AUTHOR CONTRIBUTIONS" ] 7 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2014-09-12" "fechaAceptado" => "2014-11-19" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1581482" "palabras" => array:5 [ 0 => "Posterior Cruciate Ligament" 1 => "Total Knee Arthroplasty" 2 => "Osteoarthritis" 3 => "Neuroreceptors" 4 => "Immunohistochemical Analysis" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "OBJECTIVES:Many authors recommend posterior cruciate ligament-retaining arthroplasty with the intention to maintain the proprioception properties of this ligament. Preservation of the neuroreceptors and nervous fibers may be essential for retaining the proprioception function of the posterior cruciate ligament. The present study was thus developed to evaluate the presence of neural structures in the posterior cruciate ligament resected during posterior stabilized arthroplasty in osteoarthritis patients. In particular, clinical, radiographic and histological parameters were correlated with the presence or absence of neural structures in the posterior cruciate ligament. METHODS:In total, 34 posterior cruciate ligament specimens were stained with hematoxylin-eosin and Gomori trichrome. An immunohistochemical analysis using antibodies against the S100 protein and neurofilaments was also performed. The presence of neural structures was correlated with parameters such as tibiofemoral angulation, histological degeneration of the posterior cruciate ligament, Ahlbäck radiological classification, age, gender and the histologic pattern of the synovial neurovascular bundle around the posterior cruciate ligament. RESULTS:In total, 67.5% of the cases presented neural structures in the posterior cruciate ligament. In 65% of the cases, the neurovascular bundle was degenerated. Nervous structures were more commonly detected in varus knees than in valgus knees (77% versus 50%). Additionally, severe histologic degeneration of the posterior cruciate ligament was related to neurovascular bundle degeneration. CONCLUSIONS:Severe posterior cruciate ligament degeneration was related to neurovascular bundle compromise. Neural structures were more commonly detected in varus knees. Intrinsic neural structures were detected in the majority of the posterior cruciate ligaments of patients submitted to knee arthroplasty for osteoarthritis." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVES:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "METHODS:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "RESULTS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "CONCLUSIONS:" ] ] ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "No potential conflict of interest was reported." ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig1-cln_70p81" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 511 "Ancho" => 766 "Tamanyo" => 84439 ] ] "descripcion" => array:1 [ "en" => "Gomori trichrome stain (40× magnification). Severe histological degeneration, with loss of collagen fibers and substitution by fibromyxoid tissue (black arrow)." ] ] 1 => array:7 [ "identificador" => "fig2-cln_70p81" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 420 "Ancho" => 632 "Tamanyo" => 41416 ] ] "descripcion" => array:1 [ "en" => "Immunomarking for S100 (200× magnification). Presence of a type II mechanoreceptor (Pacinian corpuscle) in the upper left field (red arrow) and a type IV mechanoreceptor (perivascular terminations) in the center of the image (black arrow)." ] ] 2 => array:7 [ "identificador" => "fig3-cln_70p81" "etiqueta" => "Figure 3" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr3.jpeg" "Alto" => 443 "Ancho" => 590 "Tamanyo" => 92854 ] ] "descripcion" => array:1 [ "en" => "Gomori trichrome stain (40× magnification). Neurovascular bundle presenting a thickened vascular tunica intima (thin black arrow), duplication of elastic fibers (thick black arrow) and nerve atrophy." ] ] 3 => array:7 [ "identificador" => "t1-cln_70p81" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Neural Immunomarking \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col">Parameters \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Present \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Absent \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Knee Alignment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Varus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">p = 0.048 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Valgus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Neutral \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Up to 70 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">p = 0.54 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">>70 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Sex \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">p = 0.44 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Ahlbäck Classification \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">I to III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">p = 0.277 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">IV and V \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">PCL Degeneration \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Mild \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">p = 0.79 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Moderate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Severe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">NVB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Absent \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">p = 0.11 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Degenerated \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Preserved \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ACL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Present \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">p = 0.14 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Absent \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Correlation between the studied parameters and the immunomarking of the neural structures of the PCL." ] ] 4 => array:7 [ "identificador" => "t2-cln_70p81" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:1 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">NVB \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col">Parameters \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Preserved \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Degenerated \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">p \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">Knee Alignment \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Varus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">p = 0.68 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Valgus \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Neutral \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Age \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Up to 70 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">p = 0.31 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">>70 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Sex \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">p = 0.20 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">Ahlbäck Classification \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">I to III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">p = 0.391 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">IV and IV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">PCL Degeneration \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Mild \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">p = 0.015 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Moderate \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Severe \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ACL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Present \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">p = 0.86 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Absent \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Correlation between the studied parameters and the state of conservation of the PCL's subsynovial NVB." ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => 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CLINICAL SCIENCE

Glaucus Cajaty MartinsI,II, Gilberto CamanhoI, Mara Ibis RodriguesIII

I Faculdade de Medicina da Universidade de São Paulo, Instituto de Ortopedia (IOT/FMUSP), Department of Orthopedics and Traumatology, São Paulo/SP, Brazil.

II Hospital Federal de Ipanema, Department of Orthopedics and Traumatology, Rio de Janeiro/RJ, Brazil.

III Faculdade de Medicina da Universidade do Estado do Rio de Janeiro (UERJ), Department of Histology, Rio de Janeiro/RJ, Brazil.

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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle50">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Total knee arthroplasty has been demonstrated to be extremely efficient in the treatment of advanced osteoarthrosis of this joint &#40;<a class="elsevierStyleCrossRef" href="#bib1">1</a>&#41;&#46;</p><p id="para20" class="elsevierStylePara elsevierViewall">Currently&#44; there are two main arthroplasty techniques&#44; which involve either preservation or replacement of the posterior cruciate ligament &#40;PCL&#41;&#46; Both techniques have yielded consistent functional results &#40;<a class="elsevierStyleCrossRef" href="#bib1">1</a>&#41;&#46;</p><p id="para30" class="elsevierStylePara elsevierViewall">The choice of the most suitable implant has generated controversy&#46; Advocates of the use of a prosthesis to preserve the PCL allege that this would ensure an increased range of motion&#44; better stair-climbing performance and enhanced proprioception &#40;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#44;<a class="elsevierStyleCrossRef" href="#bib3">3</a>&#41;&#46;</p><p id="para40" class="elsevierStylePara elsevierViewall">An innovative study performed by Kennedy et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib4">4</a>&#41; in 1982 revealed the presence of nerve fibers and mechanoreceptors in anterior and posterior cruciate ligaments&#44; menisci and capsular structures&#44; indicating that these structures may be related to proprioception&#46; These authors also described a nerve bundle in the synovium surrounding the PCL that is supposedly continuous with the tibial nerve and that carries nerve impulses&#46;</p><p id="para50" class="elsevierStylePara elsevierViewall">In subsequent studies&#44; Franchi et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#41; and Del Valle et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41; recognized Ruffini and Pacini receptors&#44; Golgi endings and nerve fiber terminals in the PCL of osteoarthritis patients submitted to prosthetic knee replacement&#46;</p><p id="para60" class="elsevierStylePara elsevierViewall">To achieve adequate biomechanical performance&#44; a knee prosthesis needs PCL preservation to ensure sufficient conservation of the anatomical and functional structures &#40;<a class="elsevierStyleCrossRef" href="#bib7">7</a>&#44;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&#46; Similarly&#44; it is necessary for the nerve endings and neuroreceptors to remain present and functional to ensure that the proprioceptive properties of the retained PCL are maintained &#40;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#41;&#46;</p><p id="para70" class="elsevierStylePara elsevierViewall">An analysis of PCL innervation in patients with advanced arthrosis is likely to be important in clinical practice&#44; as the presence of neuroreceptors remaining in the ligament would be a sign that this ligament should be preserved for proprioception purposes &#40;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41;&#46; Along the same line of reasoning&#44; if we can establish a subgroup of patients with particular clinical and&#47;or radiological parameters in whom PCL innervation is seriously impaired&#44; a posterior-stabilized prosthesis&#44; which would require the ligament to be sacrificed&#44; could be considered&#46; These data may provide additional evidence that may be used to determine the most suitable type of implant for a particular patient&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">MATERIALS AND METHODS</span><p id="para80" class="elsevierStylePara elsevierViewall">A cross-sectional study in which 31 patients &#40;34 ligaments&#41; were evaluated was conducted&#46; Of these patients&#44; 22 were female and 9 were male&#46; The patients&#39; age ranged from 53 to 87 years and they were submitted to arthroplasty with PCL replacement at our service between June 2009 and June 2011&#46;</p><p id="para90" class="elsevierStylePara elsevierViewall">This research complied with the Declaration of Helsinki and was approved by the Ethics Committee of Universidade de S&#227;o Paulo &#40;USP&#41;&#46;</p><p id="para100" class="elsevierStylePara elsevierViewall">Only cases of primary osteoarthritis were included in this series&#59; patients with rheumatic diseases and patients who underwent osteosynthesis surgery&#44; osteotomy or previous arthrotomy at the knee level and posttraumatic sequelae were excluded&#46;</p><p id="para110" class="elsevierStylePara elsevierViewall">The patients who participated in this survey signed an informed consent form declaring their awareness of the methodology and objectives of this study&#46;</p><p id="para120" class="elsevierStylePara elsevierViewall">The PCL was sectioned at its femoral origin during surgery and its tibial bone insertion was maintained&#46; This ligament was removed after tibial sectioning was performed&#46;</p><p id="para130" class="elsevierStylePara elsevierViewall">The PCL was preserved in 10&#37; formaldehyde and was subsequently placed in a paraffin mold such that the ligament fibers were oriented along the longitudinal axis&#46; The paraffin blocks were then sectioned and stained with hematoxylin-eosin&#46;</p><p id="para140" class="elsevierStylePara elsevierViewall">For Gomori trichrome staining&#44; the paraffin mold was soaked in this reagent&#46; Gomori trichrome staining is an excellent technique for ligament analysis&#44; as this reagent stains whole or new collagen fibers green&#44; aged collagen fibers red and cell nuclei purplish-blue &#40;hematoxylin&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib9">9</a>&#41;&#46;</p><p id="para150" class="elsevierStylePara elsevierViewall">For immunohistochemical analysis&#44; paraffin sections measuring approximately 10 &#181;m were processed in streptavidin-biotin-peroxidase and incubated with anti-S100 protein antibodies&#46; In the axonal neurofilament experiments&#44; the process was similar&#59; however&#44; the processed mold was instead placed in contact with anti-neurofilament antibodies&#46;</p><p id="para160" class="elsevierStylePara elsevierViewall">The S100 protein is found in the Schwann cells and myelinated fibers present in mechanoreceptors&#46; The anti-neurofilament antibody labels the cytoskeleton &#40;axon&#41;&#46;</p><p id="para170" class="elsevierStylePara elsevierViewall">Histological degeneration of the collagen fibers of the ligament was analyzed using optical microscopy &#40;OM&#41; and was classified as follows &#40;<a class="elsevierStyleCrossRef" href="#bib7">7</a>&#41;&#58;</p><p id="para180" class="elsevierStylePara elsevierViewall"><ul class="elsevierStyleList" id="celist10"><li class="elsevierStyleListItem" id="celistitem10"><span class="elsevierStyleLabel">a&#46;</span><p id="para190" class="elsevierStylePara elsevierViewall">Mild&#58; defined by impairment of fewer than 20&#37; of the collagen fibers based on an examination of 10 fields at 100&#215; magnification&#46; The predominant findings were disorganized collagen bundles in certain areas &#40;fields of the slide&#41; and an increase in slack connective tissue between the bundles&#46;</p></li><li class="elsevierStyleListItem" id="celistitem20"><span class="elsevierStyleLabel">b&#46;</span><p id="para200" class="elsevierStylePara elsevierViewall">Moderate&#58; defined by impairment of at least 20&#37; but less than 50&#37; of the collagen fibers&#46; Based on microscopic examination&#44; the predominant alterations were an inflammatory reaction&#59; hypercellularity&#59; increased vascularization and disorganized&#44; frayed or dense collagen bundles in several places&#46;</p></li><li class="elsevierStyleListItem" id="celistitem30"><span class="elsevierStyleLabel">c&#46;</span><p id="para210" class="elsevierStylePara elsevierViewall">Severe&#58; defined by the involvement of more than 50&#37; of the collagen fibers in the bundles based on the evaluation of 10 fields at 100&#215; magnification&#46; The predominant alterations observed by OM were the presence of cysts&#44; collagen degeneration &#40;fibrinoid&#47;mucoid&#47;myxoid&#41; and intratendon fatty infiltration&#44; with the possibility of total loss of the structure and integrity of the collagen fiber bundles &#40;coalescent fields&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig1-cln_70p81">Figure<span class="elsevierStyleHsp" style=""></span>1</a>&#41;&#46;</p><elsevierMultimedia ident="fig1-cln_70p81"></elsevierMultimedia></li></ul></p><p id="para220" class="elsevierStylePara elsevierViewall">The neural immunomarking of specific corpuscles and of neurofilaments was qualitatively assessed and classified as the presence or absence of marking&#46;</p><p id="para230" class="elsevierStylePara elsevierViewall">The mechanoreceptors were classified into four types according to the classification established by Freeman and Wyke &#40;<a class="elsevierStyleCrossRef" href="#bib10">10</a>&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig2-cln_70p81">Figure<span class="elsevierStyleHsp" style=""></span>2</a>&#41;&#58;<ul class="elsevierStyleList" id="celist20"><li class="elsevierStyleListItem" id="celistitem40"><span class="elsevierStyleLabel">&#8226;</span><p id="para240" class="elsevierStylePara elsevierViewall">Type I &#40;Ruffini&#41;&#58; encapsulated ovoid or globular corpuscles with slow adaptation function&#46;</p></li><li class="elsevierStyleListItem" id="celistitem50"><span class="elsevierStyleLabel">&#8226;</span><p id="para250" class="elsevierStylePara elsevierViewall">Type II &#40;Pacini&#41;&#58; elongated conical corpuscles with fast adaptation function&#46;</p></li><li class="elsevierStyleListItem" id="celistitem60"><span class="elsevierStyleLabel">&#8226;</span><p id="para260" class="elsevierStylePara elsevierViewall">Type III &#40;Golgi&#41;&#58; spindle-shaped corpuscles with fast adaptation function&#46;</p></li><li class="elsevierStyleListItem" id="celistitem70"><span class="elsevierStyleLabel">&#8226;</span><p id="para270" class="elsevierStylePara elsevierViewall">Type IV&#58; non-corpuscular endings that can be free &#40;pain&#41; or efferent and amyelinic &#40;vasomotricity&#41;&#46;</p></li></ul></p><elsevierMultimedia ident="fig2-cln_70p81"></elsevierMultimedia><p id="para280" class="elsevierStylePara elsevierViewall">The Ahlb&#228;ck classification was used to classify the radiological pattern of arthrosis into five types &#40;<a class="elsevierStyleCrossRef" href="#bib11">11</a>&#41;&#46;</p><p id="para290" class="elsevierStylePara elsevierViewall">Measurement of the tibiofemoral angulation involved knee radiographs taken with orthostatic support encompassing the distal femoral and proximal tibial diaphysis&#46; A goniometer was used to measure the tibiofemoral angle&#44; which consisted of the intersection of the femoral and tibial anatomical axes&#46; The following angles were considered&#58; varus &#40;less than or equal to 4&#176; of the tibiofemoral valgus&#41;&#44; neutral &#40;from 5&#176; to 9&#176; of the valgus&#41; and valgus &#40;above 10&#176;&#41;&#46;</p><p id="para300" class="elsevierStylePara elsevierViewall">The radiological parameters &#40;the Ahlb&#228;ck classification and the measurement of the tibiofemoral axis&#41; were evaluated together by two specialist surgeons with more than 10 years of experience in arthroplasty surgery&#46; In case of discordance&#44; a third colleague with the same training assisted in determining the end result&#46;</p><p id="para310" class="elsevierStylePara elsevierViewall">The patients were divided into two age groups&#58; 70 years and over and under 70 years&#46;</p><p id="para320" class="elsevierStylePara elsevierViewall">Based on macroscopic analysis at the time of surgery&#44; the anterior cruciate ligament &#40;ACL&#41; was considered either present or absent&#46; No attempt was made to classify the ACL as normal or undergoing macroscopic degeneration&#44; as this would generate a bias in the analysis due to extreme subjectivity&#46;</p><p id="para330" class="elsevierStylePara elsevierViewall">The neurovascular bundle &#40;NVB&#41; was classified as preserved&#44; degenerated or absent&#46; In the degenerated cases&#44; the following characteristics were observed by microscopy&#58; a thickened tunica intima in the vessels&#44; degeneration in the elastic laminae of the vascular wall and nerve atrophy demonstrated by perineural retraction &#40;<a class="elsevierStyleCrossRef" href="#fig3-cln_70p81">Figure<span class="elsevierStyleHsp" style=""></span>3</a>&#41;&#46; In the cases classified as absent&#44; the NVB was not visualized&#46; This absence of visualization can be interpreted in two ways&#58; either the NVB was not included in the histological section&#44; or it was not present&#46; The four absent cases were excluded from the statistical analysis due to these two distinct possibilities&#46;</p><elsevierMultimedia ident="fig3-cln_70p81"></elsevierMultimedia><p id="para340" class="elsevierStylePara elsevierViewall">The presence of neural structures in the PCL was evaluated and correlated with the tibiofemoral angulation &#40;varus-valgus&#41;&#44; the degree of histological degeneration of the collagen fibers&#44; the macroscopic state of the ACL&#44; Ahlb&#228;ck&#39;s radiological classification&#44; age&#44; sex and the histological state of the NVB contained in the synovium that surrounds the PCL&#46; The histological pattern of the vascular bundle &#40;preserved or degenerated&#41; was also correlated with previously described parameters&#46;</p><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">Statistical analysis</span><p id="para350" class="elsevierStylePara elsevierViewall">The chi-square test was used for analysis of parametric data and the Kruskal-Wallis test and Mann-Whitney test were used for analysis of non-parametric data&#46; Values of <span class="elsevierStyleItalic">p</span>&#60;0&#46;05 were considered significant&#46; Fisher&#39;s exact test was used for analysis of categorical data&#46;</p></span></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">RESULTS</span><p id="para360" class="elsevierStylePara elsevierViewall">Regarding the grade of histological degeneration&#44; there were 23 severe cases &#40;67&#46;5&#37;&#41;&#44; 9 moderate cases &#40;26&#46;5&#37;&#41; and 2 mild cases &#40;6&#37;&#41;&#46;</p><p id="para370" class="elsevierStylePara elsevierViewall">According to Ahlb&#228;ck&#39;s radiological classification of arthrosis&#44; there were seven grade I &#40;20&#46;5&#37;&#41;&#44; five grade II &#40;14&#46;5&#37;&#41;&#44; 14 grade III &#40;41&#37;&#41;&#44; six grade IV &#40;18&#37;&#41; and two grade V &#40;6&#37;&#41; cases&#46;</p><p id="para380" class="elsevierStylePara elsevierViewall">There were six cases of genu valgum &#40;17&#46;5&#37;&#41;&#44; 2 neutral cases &#40;6&#37;&#41; and 26 cases of genu varum &#40;76&#46;5&#37;&#41;&#46;</p><p id="para390" class="elsevierStylePara elsevierViewall">The ACL was present in 64&#46;7&#37; of cases &#40;22 cases&#41; and absent in 35&#46;3&#37; of cases &#40;12 cases&#41;&#46;</p><p id="para400" class="elsevierStylePara elsevierViewall">The NVB contained in the synovium of the PCL was identified in 30 cases &#40;88&#46;5&#37;&#41;&#44; whereas it appeared degenerated in 22 cases &#40;65&#37;&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig3-cln_70p81">Figure<span class="elsevierStyleHsp" style=""></span>3</a>&#41; and preserved in eight cases &#40;23&#46;5&#37;&#41;&#46; Additionally&#44; in 4 cases&#44; the NVB could not be identified in the histological sections &#40;11&#46;5&#37;&#41;&#46;</p><p id="para410" class="elsevierStylePara elsevierViewall">Immunomarking for neural structures was positive in 23 of the cases &#40;67&#46;5&#37;&#41;&#46; Specific mechanoreceptors were identified in 10 ligaments&#44; with 9 type II cases &#40;Pacini&#41; and six type IV cases predominating&#46; Moreover&#44; neurofilaments were identified in 14 ligaments&#46;</p><p id="para420" class="elsevierStylePara elsevierViewall">Neural immunomarking was more frequent in the genu varum &#40;77&#37;&#41; than in the genu valgum &#40;50&#37;&#41;&#59; this difference was statistically significant&#44; as demonstrated by the chi-square test &#40;<span class="elsevierStyleItalic">p</span> &#61; 0&#46;048&#41; &#40;<a class="elsevierStyleCrossRef" href="#t1-cln_70p81">Table<span class="elsevierStyleHsp" style=""></span>1</a>&#41;&#46;</p><elsevierMultimedia ident="t1-cln_70p81"></elsevierMultimedia><p id="para430" class="elsevierStylePara elsevierViewall">Immunomarking positivity was observed even at increasing levels of the Ahlb&#228;ck classification &#40;<span class="elsevierStyleItalic">p</span> &#61; 0&#46;277&#41;&#46;</p><p id="para440" class="elsevierStylePara elsevierViewall">A significant correlation was demonstrated between severe histological degeneration of the PCL and degeneration of the NVB &#40;Mann-Whitney test&#44; <span class="elsevierStyleItalic">p</span> &#61; 0&#46;015&#41; &#40;<a class="elsevierStyleCrossRef" href="#t2-cln_70p81">Table<span class="elsevierStyleHsp" style=""></span>2</a>&#41;&#46; Considering the 30 cases in which the NVB was identified&#44; in the event of severe degeneration of the PCL&#44; the NVB was degenerated 85&#46;7&#37; of the time &#40;18&#47;21 cases&#41;&#46; In the cases with mild or moderate histological impairment of the PCL&#44; the NVB was degenerated 44&#37; of the time &#40;4&#47;9 cases&#41;&#46;</p><elsevierMultimedia ident="t2-cln_70p81"></elsevierMultimedia><p id="para450" class="elsevierStylePara elsevierViewall">There was no significant relationship between the immunomarking of the neural structures or the pattern of degeneration of the NVB and the other parameters studied &#40;<a class="elsevierStyleCrossRef" href="#t1-cln_70p81">Tables<span class="elsevierStyleHsp" style=""></span>1</a>&#41; and <a class="elsevierStyleCrossRef" href="#t2-cln_70p81">2</a>&#41;&#46;</p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">DISCUSSION</span><p id="para460" class="elsevierStylePara elsevierViewall">The functional integrity of the PCL is essential for the functionality of the knee prosthesis in which this ligament is preserved&#46; The preservation of this structure&#44; at least in theory&#44; could benefit proprioception &#40;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41;&#46;</p><p id="para470" class="elsevierStylePara elsevierViewall">In 1982&#44; Kennedy et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib4">4</a>&#41; performed experiments that were based on a study by Gardiner &#40;<a class="elsevierStyleCrossRef" href="#bib12">12</a>&#41; and demonstrated that the tibial nerve is the source of the nerve fibers that innervate the synovium that surrounds the cruciate ligaments&#46; Using the silver nitrate impregnation technique&#44; these authors detected the presence of superficial axons and Golgi receptors in the PCL synovium&#46;</p><p id="para480" class="elsevierStylePara elsevierViewall">In 1984&#44; Schultz et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib13">13</a>&#41; used a similar technique and also described the presence of several unmyelinated axons in the peripheral fat &#40;synovium&#41; that coats the cruciate ligaments&#44; in addition to significant degeneration of the collagen fibers of these ligaments&#46; In 22 cruciate ligaments&#44; they observed only 1 mechanoreceptor&#46;</p><p id="para490" class="elsevierStylePara elsevierViewall">Studies conducted by Franchi et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#41; and Dell Valle et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41; revealed that neural structures and mechanoreceptors were present in the PCL of patients with arthrosis submitted to knee arthroplasty&#44; even in the presence of degeneration of the ligament&#39;s collagen fibers&#46; In fact&#44; Franchi et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#41; observed a decrease in the number of mechanoreceptors in the arthritic knee&#46; Both groups of investigators&#44; however&#44; failed to determine either the histological grade of PCL degeneration or the radiological grade of the associated arthrosis&#46;</p><p id="para500" class="elsevierStylePara elsevierViewall">Proprioception is the ability to detect movement and positioning in the space of a particular joint and is performed by neural receptors located within the joint capsule in the ligaments&#44; muscles and skin &#40;<a class="elsevierStyleCrossRef" href="#bib14">14</a>&#41;&#46;</p><p id="para510" class="elsevierStylePara elsevierViewall">In studies conducted by Barret et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#41; and Skinner &#40;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#41;&#44; the authors found that proprioception diminishes with age and that proprioception in cases of knee osteoarthritis differs from that in control individuals of the same age&#46; Disorganization of the collagen fibers of the PCL supposedly leads to greater lassitude of this ligament&#46; This process could raise the threshold of response in the nerve fibers and mechanoreceptors located along the axis of the pathologically slackened ligament&#46; Moreover&#44; the function of the afferent neural structures present in the PCL could be impaired&#44; either due to a decrease in their number or due to their degeneration&#46;</p><p id="para520" class="elsevierStylePara elsevierViewall">Several studies &#40;<a class="elsevierStyleCrossRefs" href="#bib15">15-17</a>&#41; have not described proprioception differences between patients who received a PCL replacement prosthesis and those with preservation of this ligament&#46;</p><p id="para530" class="elsevierStylePara elsevierViewall">Regarding mechanoreceptors&#44; Pacinian corpuscles predominated in the present study&#44; in accordance with studies by Franchi et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#41; and Katonis et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib18">18</a>&#41;&#44; whereas no Golgi receptors were found&#46; These results are consistent with the work of Dell Valle et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41;&#44; who did not observe this type of mechanoreceptor in humans&#46;</p><p id="para540" class="elsevierStylePara elsevierViewall">In our study&#44; in most cases &#40;67&#46;5&#37;&#41;&#44; neural structures were present in the PCL&#44; even in the presence of severe degeneration&#46; These data are in accordance with the work of Nelissen and Hogendoorn &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&#44; who examined a series of 11 knee arthrosis patients and observed eight cases of severe degeneration of the PCL&#46; In seven of these cases&#44; neural structures were present in the ligament&#46;</p><p id="para550" class="elsevierStylePara elsevierViewall">In the current study&#44; mechanoreceptors and neurofilaments were mostly present in the individuals with advanced grades of arthrosis&#44; as determined using Ahlb&#228;ck&#39;s radiological classification &#40;IV and V&#41;&#46; In contrast&#44; in the study by Nelissen and Hogendoorn &#40;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#41;&#44; in which only Ahlb&#228;ck type IV and V cases were considered&#44; neural structures were identified in all but one case&#46;</p><p id="para560" class="elsevierStylePara elsevierViewall">Positive immunomarking was significantly more likely to be observed in cases of genu varum &#40;77&#37;&#41; than in cases of genu valgum &#40;50&#37;&#41; in the present study&#46; Although statistical significance could not be determined due to the small size of the study group&#44; all six cases of genu valgum presented severe histological degeneration of the PCL&#46; Such findings support the practice of sacrificing the PCL in cases of genu valgum&#44; which has been reported by certain authors &#40;<a class="elsevierStyleCrossRef" href="#bib19">19</a>&#41;&#46; Cases of genu valgum are usually more technically demanding than those of genu varum &#40;<a class="elsevierStyleCrossRef" href="#bib19">19</a>&#41;&#46; In particular&#44; ligament release is more complex and sacrificing the PCL facilitates better ligament balance in the knee&#46; Moreover&#44; if the proprioceptive capacity of this ligament is more severely impaired in cases of valgus&#44; a posterior-stabilized prosthesis in which the PCL ligament is discarded would be more suitable based on this hypothesis&#46;</p><p id="para570" class="elsevierStylePara elsevierViewall">In our study&#44; 30&#47;34 of PCL specimens &#40;88&#37;&#41;&#44; it was possible to identify the subsynovial NVB described previously by Kennedy et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib4">4</a>&#41; and Schultz et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib13">13</a>&#41;&#46; In 22 cases &#40;64&#46;7&#37;&#41;&#44; degeneration of this bundle could be observed by microscopy&#46; Our data are consistent with those of Stubbs et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib20">20</a>&#41;&#44; who examined 50 PCLs from arthrosis patients submitted to arthroplasty and found arteriosclerosis and perineural fibrosis in 78&#37; and 50&#37; of the ligaments studied&#44; respectively&#44; after histological analysis&#46;</p><p id="para580" class="elsevierStylePara elsevierViewall">Degenerative alterations of the NVB could lead to impaired function and decreased transmission of impulses captured in the knee&#46; This degeneration of the subsynovial NVB should be studied in more depth&#44; as it could be&#44; at least in theory&#44; one of the factors responsible for the proprioception deficit of arthritic patients&#46;</p><p id="para590" class="elsevierStylePara elsevierViewall">A significant statistical correlation &#40;<span class="elsevierStyleItalic">p</span> &#61; 0&#46;015&#41; was identified between the grade of PCL degeneration and the state of the NVB in the current study&#46; The cases of severe histological degeneration of the PCL were related to degenerated NVBs 80&#37; of the time and to impaired bundles 44&#37; of the time in cases of mild or moderate degeneration&#46; These data are important because if we can identify patients with severe PCL degeneration&#44; aside from altered biomechanical properties&#44; this may be an indicator of deficient proprioception in the ligament&#46; Under this potential set of circumstances&#44; PCL replacement arthroplasty would&#44; in theory&#44; be an indication to consider&#46;</p><p id="para600" class="elsevierStylePara elsevierViewall">The good results obtained with prostheses with preservation of the PCL&#44; despite advanced degeneration in many cases&#44; could be due to the design of the implants&#59; the ligament plays a secondary role when applying an axial load to the prosthesis &#40;<a class="elsevierStyleCrossRef" href="#bib20">20</a>&#41;&#46; In addition&#44; after arthroplasty&#44; the collateral ligaments and the capsule are responsible for knee proprioception&#44; which helps to explain the similar results obtained using prostheses with and without sacrifice of the PCL &#40;<a class="elsevierStyleCrossRef" href="#bib20">20</a>&#41;&#46;</p><p id="para610" class="elsevierStylePara elsevierViewall">This study has certain limitations&#46; The first is that the immunomarking analysis was merely qualitative&#59; thus&#44; the density of the ligament innervation was not quantified&#46; Another weak point is the use of Ahlb&#228;ck&#39;s radiological classification&#44; which has limited reproducibility &#40;<a class="elsevierStyleCrossRef" href="#bib21">21</a>&#41;&#59; however&#44; it is the most widely used classification system among orthopedic surgeons&#46; The method by which the grade of histological PCL degeneration was evaluated was also subjective&#44; although this method was based on previous studies &#40;<a class="elsevierStyleCrossRef" href="#bib7">7</a>&#44;<a class="elsevierStyleCrossRef" href="#bib20">20</a>&#44;<a class="elsevierStyleCrossRef" href="#bib22">22</a>&#41; and conducted by a histologist with extensive experience in scientific studies&#46; One strong point of the study is that it was performed in patients submitted to surgery in whom neural structures were identified using one of the most widely accepted current techniques&#58; immunomarking for S100 and neurofilaments&#46; Furthermore&#44; we demonstrated the relationship between severe degeneration of the PCL and impairment of the NVB&#46; We also established that neural structures are more commonly present in cases of varus deformity than in cases of valgus deformity&#46; These original results pave the way for the development of new questions&#46; Additionally&#44; the results should inspire surveys geared toward the identification of epidemiological&#44; clinical and radiological parameters that may be related to the histological and functional states of the PCL and its applications in surgical practice&#46;</p><p id="para620" class="elsevierStylePara elsevierViewall">The topic of articular mechanoreceptors is far from being merely academic&#44; as it has served as one of the foundations of prestigious authors &#40;<a class="elsevierStyleCrossRef" href="#bib1">1</a>&#44;<a class="elsevierStyleCrossRef" href="#bib6">6</a>&#41; recommendation of PCL preservation in knee arthroplasty&#46; Additionally&#44; articular mechanoreceptors have been the subject of recent surveys on other joints&#44; such as the shoulder &#40;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#41; and intervertebral disc &#40;<a class="elsevierStyleCrossRef" href="#bib23">23</a>&#41;&#46;</p></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">CONCLUSION</span><p id="para630" class="elsevierStylePara elsevierViewall">1&#41; Intrinsic neural structures were detected in the majority of the PCLs of patients submitted to knee arthroplasty for osteoarthritis&#44; even in the presence of severe structural degeneration of the ligament&#39;s collagen fibers&#46; 2&#41; There was an association between severe PCL degeneration and NVB compromise&#46; 3&#41; Neural structures were more frequently observed in varus knees than in valgus knees&#46;</p></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">AUTHOR CONTRIBUTIONS</span><p id="para640" class="elsevierStylePara elsevierViewall">Martins GC conceived the study&#44; harvested the ligaments&#44; the data and wrote the manuscript&#46; Camanho GL analyzed the data and revised the manuscript&#46; Rodrigues MI performed the histological analysis&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:8 [
        0 => array:2 [
          "identificador" => "xpalclavsec1581482"
          "titulo" => "KEYWORDS"
        ]
        1 => array:2 [
          "identificador" => "cesec10"
          "titulo" => "INTRODUCTION"
        ]
        2 => array:3 [
          "identificador" => "cesec20"
          "titulo" => "MATERIALS AND METHODS"
          "secciones" => array:1 [
            0 => array:2 [
              "identificador" => "cesec30"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        3 => array:2 [
          "identificador" => "cesec40"
          "titulo" => "RESULTS"
        ]
        4 => array:2 [
          "identificador" => "cesec50"
          "titulo" => "DISCUSSION"
        ]
        5 => array:2 [
          "identificador" => "cesec60"
          "titulo" => "CONCLUSION"
        ]
        6 => array:2 [
          "identificador" => "cesec70"
          "titulo" => "AUTHOR CONTRIBUTIONS"
        ]
        7 => array:1 [
          "titulo" => "REFERENCES"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2014-09-12"
    "fechaAceptado" => "2014-11-19"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "KEYWORDS"
          "identificador" => "xpalclavsec1581482"
          "palabras" => array:5 [
            0 => "Posterior Cruciate Ligament"
            1 => "Total Knee Arthroplasty"
            2 => "Osteoarthritis"
            3 => "Neuroreceptors"
            4 => "Immunohistochemical Analysis"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVES&#58;</span><p id="spara60" class="elsevierStyleSimplePara elsevierViewall">Many authors recommend posterior cruciate ligament-retaining arthroplasty with the intention to maintain the proprioception properties of this ligament&#46; Preservation of the neuroreceptors and nervous fibers may be essential for retaining the proprioception function of the posterior cruciate ligament&#46; The present study was thus developed to evaluate the presence of neural structures in the posterior cruciate ligament resected during posterior stabilized arthroplasty in osteoarthritis patients&#46; In particular&#44; clinical&#44; radiographic and histological parameters were correlated with the presence or absence of neural structures in the posterior cruciate ligament&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHODS&#58;</span><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">In total&#44; 34 posterior cruciate ligament specimens were stained with hematoxylin-eosin and Gomori trichrome&#46; An immunohistochemical analysis using antibodies against the S100 protein and neurofilaments was also performed&#46; The presence of neural structures was correlated with parameters such as tibiofemoral angulation&#44; histological degeneration of the posterior cruciate ligament&#44; Ahlb&#228;ck radiological classification&#44; age&#44; gender and the histologic pattern of the synovial neurovascular bundle around the posterior cruciate ligament&#46;</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS&#58;</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">In total&#44; 67&#46;5&#37; of the cases presented neural structures in the posterior cruciate ligament&#46; In 65&#37; of the cases&#44; the neurovascular bundle was degenerated&#46; Nervous structures were more commonly detected in varus knees than in valgus knees &#40;77&#37; <span class="elsevierStyleItalic">versus</span> 50&#37;&#41;&#46; Additionally&#44; severe histologic degeneration of the posterior cruciate ligament was related to neurovascular bundle degeneration&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSIONS&#58;</span><p id="spara90" class="elsevierStyleSimplePara elsevierViewall">Severe posterior cruciate ligament degeneration was related to neurovascular bundle compromise&#46; Neural structures were more commonly detected in varus knees&#46; Intrinsic neural structures were detected in the majority of the posterior cruciate ligaments of patients submitted to knee arthroplasty for osteoarthritis&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "ceabs10"
            "titulo" => "OBJECTIVES&#58;"
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          1 => array:2 [
            "identificador" => "ceabs20"
            "titulo" => "METHODS&#58;"
          ]
          2 => array:2 [
            "identificador" => "ceabs30"
            "titulo" => "RESULTS&#58;"
          ]
          3 => array:2 [
            "identificador" => "ceabs40"
            "titulo" => "CONCLUSIONS&#58;"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">No potential conflict of interest was reported&#46;</p>"
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig1-cln_70p81"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr1.jpeg"
            "Alto" => 511
            "Ancho" => 766
            "Tamanyo" => 84439
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        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Gomori trichrome stain &#40;40&#215; magnification&#41;&#46; Severe histological degeneration&#44; with loss of collagen fibers and substitution by fibromyxoid tissue &#40;black arrow&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig2-cln_70p81"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr2.jpeg"
            "Alto" => 420
            "Ancho" => 632
            "Tamanyo" => 41416
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Immunomarking for S100 &#40;200&#215; magnification&#41;&#46; Presence of a type II mechanoreceptor &#40;Pacinian corpuscle&#41; in the upper left field &#40;red arrow&#41; and a type IV mechanoreceptor &#40;perivascular terminations&#41; in the center of the image &#40;black arrow&#41;&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "fig3-cln_70p81"
        "etiqueta" => "Figure 3"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "gr3.jpeg"
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        "descripcion" => array:1 [
          "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Gomori trichrome stain &#40;40&#215; magnification&#41;&#46; Neurovascular bundle presenting a thickened vascular tunica intima &#40;thin black arrow&#41;&#44; duplication of elastic fibers &#40;thick black arrow&#41; and nerve atrophy&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "t1-cln_70p81"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
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                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Neural Immunomarking&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">Parameters&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Present&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Absent&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Knee Alignment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Varus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top"><span class="elsevierStyleItalic">p</span> &#61; 0&#46;048&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Valgus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Neutral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Up to 70 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top"><span class="elsevierStyleItalic">p</span> &#61; 0&#46;54&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62;70 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top"><span class="elsevierStyleItalic">p</span> &#61; 0&#46;44&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Ahlb&#228;ck Classification&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>I to III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top"><span class="elsevierStyleItalic">p</span> &#61; 0&#46;277&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>IV and V&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">PCL Degeneration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mild&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top"><span class="elsevierStyleItalic">p</span> &#61; 0&#46;79&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Moderate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">NVB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Absent&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top"><span class="elsevierStyleItalic">p</span> &#61; 0&#46;11&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Degenerated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Preserved&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">ACL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Present&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top"><span class="elsevierStyleItalic">p</span> &#61; 0&#46;14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Absent&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Correlation between the studied parameters and the immunomarking of the neural structures of the PCL&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "t2-cln_70p81"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:1 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">NVB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">Parameters&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Preserved&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Degenerated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">Knee Alignment&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Varus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top"><span class="elsevierStyleItalic">p</span> &#61; 0&#46;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Valgus&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Neutral&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Age&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Up to 70 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top"><span class="elsevierStyleItalic">p</span> &#61; 0&#46;31&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>&#62;70 years&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Sex&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top"><span class="elsevierStyleItalic">p</span> &#61; 0&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">14&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">Ahlb&#228;ck Classification&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>I to III&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top"><span class="elsevierStyleItalic">p</span> &#61; 0&#46;391&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>IV and IV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">PCL Degeneration&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Mild&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top"><span class="elsevierStyleItalic">p</span> &#61; 0&#46;015&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Moderate&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Severe&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">ACL&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Present&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">13&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top"><span class="elsevierStyleItalic">p</span> &#61; 0&#46;86&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Absent&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
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        "descripcion" => array:1 [
          "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">Correlation between the studied parameters and the state of conservation of the PCL&#39;s subsynovial NVB&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:23 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Retention versus removal of the posterior cruciate ligament in total knee replacement&#58; a systematic literature review within the Cochrane framework"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              WC Jacobs \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              DJ Clement \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              AB Wymenga \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1080/17453670510045345"
                      "Revista" => array:7 [
                        "tituloSerie" => "Acta Orthop"
                        "fecha" => "2005"
                        "volumen" => "76"
                        "numero" => "6"
                        "paginaInicial" => "757"
                        "paginaFinal" => "768"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16470427"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Joint proprioception in normal&#44; osteoarthritic and replaced knees"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              DS Barrett \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AG Cobb \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              G Bentley \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1302/0301-620X.73B1.1991775"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Bone Joint Surg Br"
                        "fecha" => "1991"
                        "volumen" => "73"
                        "numero" => "1"
                        "paginaInicial" => "53"
                        "paginaFinal" => "56"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1991775"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Retention of the posterior cruciate in total knee arthroplasty"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              TP Andriacchi \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              JO Galante \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0883-5403(88)80003-2"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Arthroplasty"
                        "fecha" => "1988"
                        "volumen" => "3"
                        "numero" => "Suppl"
                        "paginaInicial" => "S13"
                        "paginaFinal" => "S19"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3199135"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Nerve supply of the human knee and its functional importance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              JC Kennedy \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              IJ Alexander \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              KC Hayes \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1177/036354658201000601"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Sports Med"
                        "fecha" => "1982"
                        "volumen" => "10"
                        "numero" => "6"
                        "paginaInicial" => "329"
                        "paginaFinal" => "335"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6897495"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Neural system of the human posterior cruciate ligament in osteoarthritis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              A Franchi \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              G Zaccherotti \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              P Aglietti \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/s0883-5403(05)80215-3"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Arthroplasty"
                        "fecha" => "1995"
                        "volumen" => "10"
                        "numero" => "5"
                        "paginaInicial" => "679"
                        "paginaFinal" => "682"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9273382"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunohistochemical analysis of mechanoreceptors in the human posterior cruciate ligament&#58; a demonstration of its proprioceptive role and clinical relevance"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
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Article information

ISSN: 18075932
Original language: English

DOI:10.6061/clinics/2015(02)02

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