The roles of Tenascin C and Fibronectin 1 in adhesive capsulitis: a pilot gene expression study

array:24 ["pii" => "S1807593222010912" "issn" => "18075932" "doi" => "10.6061/clinics/2016(06)07" "estado" => "S300" "fechaPublicacion" => "2016-01-01" "aid" => "1091" "copyright" => "CLINICS" "copyrightAnyo" => "2016" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by/4.0/" "subdocumento" => "fla" "cita" => "Clinics. 2016;71:325-31" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S1807593222010924" "issn" => "18075932" "doi" => "10.6061/clinics/2016(06)08" "estado" => "S300" "fechaPublicacion" => "2016-01-01" "aid" => "1092" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by/4.0/" "subdocumento" => "fla" "cita" => "Clinics. 2016;71:332-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "Reduced placental volume and flow in severe growth restricted fetuses" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "332" "paginaFinal" => "337" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Renata Montes Dourado Abulé, Lisandra Stein Bernardes, Giovana Farina Doro, Seizo Miyadahira, Rossana Pulcinelli Vieira Francisco" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Renata Montes Dourado" "apellidos" => "Abulé" ] 1 => array:2 [ "nombre" => "Lisandra Stein" "apellidos" => "Bernardes" ] 2 => array:2 [ "nombre" => "Giovana Farina" "apellidos" => "Doro" ] 3 => array:2 [ "nombre" => "Seizo" "apellidos" => "Miyadahira" ] 4 => array:2 [ "nombre" => "Rossana Pulcinelli Vieira" "apellidos" => "Francisco" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222010924?idApp=UINPBA00004N" "url" => "/18075932/0000007100000006/v1_202211291053/S1807593222010924/v1_202211291053/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1807593222010900" "issn" => "18075932" "doi" => "10.6061/clinics/2016(06)06" "estado" => "S300" "fechaPublicacion" => "2016-01-01" "aid" => "1090" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by/4.0/" "subdocumento" => "fla" "cita" => "Clinics. 2016;71:320-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "Application of bioabsorbable screw fixation for anterior cervical decompression and bone grafting" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "320" "paginaFinal" => "324" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig2-cln_71p320" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "cln-71-06-320-g002.jpeg" "Alto" => 738 "Ancho" => 800 "Tamanyo" => 103101 ] ] "descripcion" => array:1 [ "en" => "Imaging examinations of a patient who underwent C5-7 fusion. A: Radiograph, lateral view; pre-operation. B: Radiograph, lateral view; post-operation. C: Computed tomography scan, axial view; note the poly L/lactide screws (arrow). D: Three-dimensional reconstruction of the graft. E: Magnetic resonance imaging scan, axial view; pre-operation. F: Magnetic resonance imaging scan, axial view; post-operation." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Bo Zhao, Xiaowen Qiu, Dong Wang, Haopeng Li, Xijing He" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Bo" "apellidos" => "Zhao" ] 1 => array:2 [ "nombre" => "Xiaowen" "apellidos" => "Qiu" ] 2 => array:2 [ "nombre" => "Dong" "apellidos" => "Wang" ] 3 => array:2 [ "nombre" => "Haopeng" "apellidos" => "Li" ] 4 => array:2 [ "nombre" => "Xijing" "apellidos" => "He" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222010900?idApp=UINPBA00004N" "url" => "/18075932/0000007100000006/v1_202211291053/S1807593222010900/v1_202211291053/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "The roles of Tenascin C and Fibronectin 1 in adhesive capsulitis: a pilot gene expression study" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "325" "paginaFinal" => "331" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Carina Cohen, Mariana Ferreira Leal, Paulo Santoro Belangero, Eduardo Antônio Figueiredo, Marília Cardoso Smith, Carlos Vicente Andreoli, Alberto de Castro Pochini, Moises Cohen, Benno Ejnisman, Flávio Faloppa" "autores" => array:10 [ 0 => array:3 [ "nombre" => "Carina" "apellidos" => "Cohen" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "af1-cln_71p325" ] 1 => array:2 [ "etiqueta" => "#" "identificador" => "c2-cln_71p325" ] ] ] 1 => array:4 [ "nombre" => "Mariana Ferreira" "apellidos" => "Leal" "email" => array:1 [ 0 => "mariana.morf@epm.br" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "af1-cln_71p325" ] 1 => array:2 [ "etiqueta" => "II" "identificador" => "af2-cln_71p325" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "c1-cln_71p325" ] 3 => array:2 [ "etiqueta" => "#" "identificador" => "c2-cln_71p325" ] ] ] 2 => array:3 [ "nombre" => "Paulo Santoro" "apellidos" => "Belangero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "af1-cln_71p325" ] ] ] 3 => array:3 [ "nombre" => "Eduardo Antônio" "apellidos" => "Figueiredo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "af1-cln_71p325" ] ] ] 4 => array:3 [ "nombre" => "Marília Cardoso" "apellidos" => "Smith" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "II" "identificador" => "af2-cln_71p325" ] ] ] 5 => array:3 [ "nombre" => "Carlos Vicente" "apellidos" => "Andreoli" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "af1-cln_71p325" ] ] ] 6 => array:3 [ "nombre" => "Alberto" "apellidos" => "de Castro Pochini" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "af1-cln_71p325" ] ] ] 7 => array:3 [ "nombre" => "Moises" "apellidos" => "Cohen" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "af1-cln_71p325" ] ] ] 8 => array:3 [ "nombre" => "Benno" "apellidos" => "Ejnisman" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "af1-cln_71p325" ] ] ] 9 => array:3 [ "nombre" => "Flávio" "apellidos" => "Faloppa" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "af1-cln_71p325" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Universidade Federal de São Paulo, Departamento de Ortopedia e Traumatologia" "etiqueta" => "I" "identificador" => "af1-cln_71p325" ] 1 => array:3 [ "entidad" => "Departamento de Morfologia e Genética, Disciplina de Genética, São Paulo/SP, Brazil" "etiqueta" => "II" "identificador" => "af2-cln_71p325" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig2-cln_71p325" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "cln-71-06-325-g002.jpeg" "Alto" => 617 "Ancho" => 800 "Tamanyo" => 52674 ] ] "descripcion" => array:1 [ "en" => "Correlation between gene expression and duration of adhesive capsulitis (months). A) TGFβ1; B) TGFβR1; C) LOX; D) PLOD1; E) PLOD2; F) COMP; G) FN1; H) TNC; and I) TNXB. ρ: Spearman correlation coefficient (“rho”). *Significant correlation (p<0.05). A lower delta cycle threshold value (ΔCrt) indicates higher gene expression." ] ] ] "textoCompleto" => "INTRODUCTIONAdhesive capsulitis, or frozen shoulder, is a debilitating condition in which patients present limited active and passive glenohumeral motion. Adhesive capsulitis occurs in 3%-5% of the general population <a class="elsevierStyleCrossRef" href="#bib1">1</a> and the main cause of the painful restriction of movement is inflammatory contracture of the joint capsule. The initial inflammation seems to lead to capsular fibrosis, stiffness and pain <a class="elsevierStyleCrossRef" href="#bib2">2</a>. Therefore, it has been hypothesized that similarities exist between adhesive capsulitis and the fibrous contractures that occur in Dupuytren disease <a class="elsevierStyleCrossRef" href="#bib3">3</a>,<a class="elsevierStyleCrossRef" href="#bib4">4</a>. However, the molecular mechanism responsible for the underlying glenohumeral capsule inflammation and fibrosis is poorly understood.Rodeo et al. suggested that cytokines, such as transforming growth factor beta (TGFβ), may be involved in the inflammatory and fibrotic processes that occur in adhesive capsulitis. These cytokines may cause abnormal regulation of collagen expression and augment fibroblast proliferation <a class="elsevierStyleCrossRef" href="#bib5">5</a>. Therefore, TGFβ acts as a persistent stimulus that leads to capsular fibrosis.TGFβ induces fibroblasts to synthesize, remodel and contract extracellular matrix (ECM), making this cytokine a key mediator of the fibrotic response <a class="elsevierStyleCrossRef" href="#bib6">6</a>. TGFβ is activated by proteolytic cleavage <a class="elsevierStyleCrossRef" href="#bib7">7</a> mediated by the signaling receptors TGFβ receptor I (TGFβR1) and TGFβ receptor 2 (TGFβR2) <a class="elsevierStyleCrossRef" href="#bib8">8</a>. TGFBR1 is the principal propagator of TGFβ signaling <a class="elsevierStyleCrossRef" href="#bib9">9</a>.TGFβ1, a key member of the TGFβ superfamily, regulates the collagen-modifying enzymes lysyl oxidase (LOX) <a class="elsevierStyleCrossRef" href="#bib10">10</a> and lysyl hydroxylases 1 and 2 (encoded by the PLOD1 and PLOD2 genes, respectively) <a class="elsevierStyleCrossRefs" href="#bib11">11-13</a>. LOX plays a role in connective tissue matrix biogenesis through the oxidation of lysine residues in collagen and elastin, contributing to the formation of covalent cross-links and thereby stabilizing fibrous ECM proteins <a class="elsevierStyleCrossRef" href="#bib14">14</a>,<a class="elsevierStyleCrossRef" href="#bib15">15</a>. In several fibrotic injuries, TGFβ1 controls the expression and enzymatic activity of LOX <a class="elsevierStyleCrossRef" href="#bib10">10</a>.Lysyl hydroxylases such as PLOD1 and PLOD2 promote cross-linking in ECM molecules, which contribute to ECM structural stability and maturation <a class="elsevierStyleCrossRef" href="#bib16">16</a>,<a class="elsevierStyleCrossRef" href="#bib17">17</a>. Increased PLOD2 expression has been reported in fibroblasts isolated from hypertrophic scars, keloids and palmar fascia from patients with Dupuytren disease <a class="elsevierStyleCrossRef" href="#bib18">18</a>. To the best of our knowledge, no previous studies have evaluated the roles of lysyl oxidase and hydroxylase in adhesive capsulitis.TGFβ regulates and is regulated by several ECM proteins. Cartilage oligomeric matrix protein (COMP), a glycoprotein found in the ECM of joints, plays a catalytic role in fibrillogenesis <a class="elsevierStyleCrossRef" href="#bib19">19</a>. Recent studies have shown that COMP also directly binds members of the TGFβ superfamily of proteins, including TGFβ1 <a class="elsevierStyleCrossRef" href="#bib20">20</a>. Haudenschild et al. showed that TGFβ1 displays enhanced bioactivity when bound to COMP <a class="elsevierStyleCrossRef" href="#bib20">20</a>. In addition, TGFβ1 appears to have the capacity to induce COMP expression <a class="elsevierStyleCrossRef" href="#bib21">21</a>.Fibronectin (FN), a glycoprotein encoded by the FN1 gene, is involved in several biological processes, including cell adhesion, tissue development and wound healing <a class="elsevierStyleCrossRef" href="#bib22">22</a>. FN also has a role in TGFβ regulation <a class="elsevierStyleCrossRef" href="#bib23">23</a>. Moreover, FN expression increases under stimuli induced by TGFβ <a class="elsevierStyleCrossRef" href="#bib24">24</a>.Moreover, the tenascins (TN), including TNR, TNC and TNX, are a highly conserved family of ECM glycoproteins. TNR is expressed only in the brain, whereas TNC and TNX are expressed in several organs and tissues, including in the joints <a class="elsevierStyleCrossRef" href="#bib25">25</a>. TNC has an important role in modulating the actions of TGFβ <a class="elsevierStyleCrossRef" href="#bib26">26</a> and is also regulated by TGFβ <a class="elsevierStyleCrossRef" href="#bib27">27</a>. TNXB seems to regulate collagen synthesis or deposition <a class="elsevierStyleCrossRef" href="#bib28">28</a>. A recent study showed that TNX also regulates TGFβ bioavailability and modulates cell plasticity <a class="elsevierStyleCrossRef" href="#bib29">29</a>.In the present study, we quantified the mRNA expression of the TGFβ1, TGFβR1, LOX, PLOD1, PLOD2, COMP, FN1, TNC and TNXB genes in glenohumeral synovium/capsule samples collected from patients with adhesive capsulitis and from controls. We also evaluated how these mRNA levels are associated with clinical features.MATERIALS AND METHODSPatientsThe current study used a case-control study design (level 3 evidence). All patients and controls were treated at the Hospital São Paulo of the Universidade Federal de São Paulo. Each patient agreed to participate by signing a written consent form before data and sample collection. This study was approved by the ethics committee of the Universidade Federal de São Paulo (approval number: CEP 1918/11).The case group was composed of 9 patients with idiopathic adhesive capsulitis of the shoulder in freezing or frozen stages who were diagnosed by clinical evaluation. During the clinical evaluations, the patients presented with pain, loss of motion and severe limitations during daily activities; no history of trauma or previous shoulder pathologies; and functional restriction of both active and passive shoulder motion. Magnetic resonance imaging (MRI) was used to exclude secondary stiff shoulder. The patients underwent arthroscopic shoulder capsular release after a concerted effort was made to treat them with conservative management for at least 5 complete months. In all cases, the physiotherapy had failed. Additionally,patients meeting the following exclusion criteria were omitted: generalized arthritis; previous compromise of the shoulder, such as major trauma, fracture, rotator cuff tear, calcifying tendinitis, or shoulder instability; and superior labral anterior and posterior (SLAP) lesions. Additionally, patients who did not agree with the informed consent terms were excluded. All enrolled patients underwent an arthroscopic procedure.The control group consisted of 8 physically active subjects who underwent arthroscopically assisted treatment for acute acromioclavicular dislocation. None of the controls presented with a history of adhesive capsulitis. Moreover, radiological indication of glenohumeral capsule alteration was detected. A standard complete joint evaluation by arthroscopy confirmed that the controls did not present any other concomitant pathology in the shoulder.All patients answered a preoperative questionnaire concerning gender, age at surgery, age of pain onset, duration of symptoms, bilaterality, suprascapular nerve block, physical activity, type of work and smoking habits (<a class="elsevierStyleCrossRef" href="#t1-cln_71p325">Table 1</a>).<elsevierMultimedia ident="t1-cln_71p325"></elsevierMultimedia>Tissue samplesTissue samples of approximately 2 mm3 were obtained from the anterior-inferior portion of the glenohumeral capsule during the arthroscopic procedure. To reduce sampling variation, only two of the authors (CC and BE) were responsible for collecting the tissue samples. The samples were collected as previously described <a class="elsevierStyleCrossRefs" href="#bib30">30-32</a>. As the synovium is adhered to the capsule, it cannot be separated from the capsule using arthroscopic instruments.To provide immediate stabilization of RNA, all synovium/capsule specimens were instantly preserved in Allprotect Tissue Reagent® (Qiagen, Germany) and then stored at -20 °C.RNA extractionAn AllPrep DNA/RNA/miRNA Universal Kit (Qiagen, Germany) was used to purify total RNA from the synovium/capsule specimens. Tissue Lyser LT equipment (Qiagen, USA) was used to mechanically lyse the tissue samples. A NanoDrop ND-1000 spectrophotometer (Thermo Scientific, USA) was used to determine RNA concentration and quality. RNA integrity was verified by 1% agarose gel electrophoresis. The RNA samples were stored at -80 °C.mRNA expression analysisReverse transcription-quantitative polymerase chain reaction (RT-qPCR) was used to evaluate mRNA expression. First, a High-Capacity cDNA Archive kit (Life Technologies, USA) was used for cDNA synthesis. Then, RT-qPCR was performed as previously described using a ViiA 7 Real-Time PCR System (Life Technologies, USA) <a class="elsevierStyleCrossRef" href="#bib30">30</a>. To exclude technical variations, target and reference genes (<a class="elsevierStyleCrossRef" href="#t2-cln_71p325">Table 2</a>) were analyzed on the same TaqMan Low-Density Array (TLDA) cards (Life Technologies, USA). All qPCR assays were performed in triplicate. The B2M and HPRT1 genes were used as reference genes to normalize sample input amount. These genes were chosen based on a previous study of suitable internal controls for the evaluation of mRNA expression in shoulder capsule samples <a class="elsevierStyleCrossRef" href="#bib33">33</a>.<elsevierMultimedia ident="t2-cln_71p325"></elsevierMultimedia>The relative cycle threshold method (Crt method) was used to quantify mRNA expression. In this method, the lower the cycle threshold value (Crt) value, the greater the number of initial target copies in the sample. Thus, low Crt values indicate high gene expression. The expression of the target genes was determined using the following equation: ΔCrt=target gene Crt – the mean of the reference genes Crt.Statistical analysisAll ΔCrt values are shown as the median with the interquartile range (IQR).The gender and age distributions between the patients with adhesive capsulitis and the controls were compared using the Chi-square test and the Mann-Whitney test, respectively. The Mann-Whitney test was also applied to compare mRNA levels between the cases and the controls, as well as to investigate the possible associations between mRNA expression and preoperative clinical variables, such as gender, practice of sports involving the upper limbs, type of job (manual versus non-manual job) and smoking habits. Spearman's correlation was used to assess possible correlations between mRNA levels and duration of symptoms or age at surgery: a value below 0.40 was considered a weak correlation, a value between 0.40 and 0.59 was considered a moderate correlation, a value between 0.6 and 0.79 was considered a strong correlation and a value ≥0.80 was considered a very strong correlation. For all analyses, a p-value<0.05 was considered statistically significant. Statistical analyses were performed using PASW (SPSS) software, version 18 (SPSS Inc., Chicago, USA).RESULTSDifferences between cases and controls<a class="elsevierStyleCrossRef" href="#t1-cln_71p325">Table 1</a> presents the clinical variables of the study participants. In the control group, 1 (12.5%) individual was female and 7 (87.5%) were males. The median age at the time of surgery was 31.44 years (IQR=13.5). The gender distribution did not differ between the study groups (p=0.05). However, the controls were significantly younger than the patients with adhesive capsulitis (p=0.012, Mann-Whitney test).<a class="elsevierStyleCrossRef" href="#t3-cln_71p325">Table 3</a> shows the median and IQR values for the expression levels of the studied genes in the samples from the patients and the controls. The patients with adhesive capsulitis had higher levels of TNC (p=0.005; <a class="elsevierStyleCrossRef" href="#fig1-cln_71p325">Figure 1A</a>) and FN1 (p=0.043; <a class="elsevierStyleCrossRef" href="#fig1-cln_71p325">Figure 1B</a>) expression compared to the controls. No other significant differences were observed between the patients and the controls (p>0.05).<elsevierMultimedia ident="t3-cln_71p325"></elsevierMultimedia><elsevierMultimedia ident="fig1-cln_71p325"></elsevierMultimedia>Associations between the clinical characteristics of adhesive capsulitis and mRNA expression<a class="elsevierStyleCrossRef" href="#fig2-cln_71p325">Figure 2</a> shows the correlations between the duration of adhesive capsulitis symptoms and the expression levels of the studied genes. In the tissue samples, the expression of TGFβR1 mRNA was significantly and directly correlated with the duration of symptoms (ρ=-0.731, p=0.025; <a class="elsevierStyleCrossRef" href="#fig2-cln_71p325">Figure 2B</a>).<elsevierMultimedia ident="fig2-cln_71p325"></elsevierMultimedia>No correlation was found between the age of the patients at the time of surgery and the age at symptom onset (p>0.05). Additionally, no association was found between the mRNA levels of the studied genes and any of the clinical features assessed in the patients with adhesive capsulitis (p>0.05).DISCUSSIONAlthough adhesive capsulitis is considered a self-limited disease, some patients show little to no improvement, maintain a limited range of motion and continue to experience shoulder pain. Non-operative treatment is the initial approach used for adhesive capsulitis. However, operative treatment (such as arthroscopic capsular release) may be considered when patients remain in pain and do not regain satisfactory range of motion after prolonged nonoperative treatment <a class="elsevierStyleCrossRef" href="#bib34">34</a>,<a class="elsevierStyleCrossRef" href="#bib35">35</a>.In this study, we found higher levels of TNC and FN1 expression in glenohumeral synovium/capsule samples collected from patients with adhesive capsulitis compared to those collected from controls. TNC immunoreactivity was previously reported in other shoulder diseases, including in rotator cuff tendon tears and in the subacromial bursa of patients with impingement syndrome <a class="elsevierStyleCrossRef" href="#bib36">36</a>,<a class="elsevierStyleCrossRef" href="#bib37">37</a>. In addition, we have previously found that both TNC and FN1 mRNA levels were upregulated in the glenohumeral capsules of patients with traumatic anterior shoulder instability (unpublished data). TNC is a large hexameric ECM glycoprotein that has roles in cell adhesion, fibroblast migration and other processes related to tissue remodeling and wound healing <a class="elsevierStyleCrossRef" href="#bib38">38</a>,<a class="elsevierStyleCrossRef" href="#bib39">39</a>. TNC is specifically expressed following tissue damage, being upregulated within 24 h of injury <a class="elsevierStyleCrossRef" href="#bib38">38</a>. It is activated after local injury and down-regulated after tissue repair or scarring is completed <a class="elsevierStyleCrossRef" href="#bib40">40</a>. Persistent expression of TNC is associated with several fibrotic diseases and with chronic non-healing wounds <a class="elsevierStyleCrossRef" href="#bib38">38</a>.Therefore, we hypothesize that increased TNC expression may be a marker of capsule injury and the genes involved may participate in inflammatory and fibrotic processes in the glenohumeral capsule.FN is essential for collagen fibril assembly <a class="elsevierStyleCrossRef" href="#bib41">41</a>. During the early phase of wound healing, FN is deposited at sites of injury and can induce inflammation; increase ECM deposition, including of FN and collagen; and activate fibroblasts. These pathways can create a vicious cycle that eventually induces keloid formation or fibrosis <a class="elsevierStyleCrossRef" href="#bib42">42</a>. Additionally, FN has been previously associated with Dupuytren's contracture <a class="elsevierStyleCrossRef" href="#bib24">24</a>. In this disease, FN can be found in its oncofetal form <a class="elsevierStyleCrossRef" href="#bib43">43</a>,<a class="elsevierStyleCrossRef" href="#bib44">44</a>. Additionally, upregulation of FN1 has been associated with fibrosis in inflammatory orbital diseases <a class="elsevierStyleCrossRef" href="#bib45">45</a>, hepatic fibrosis <a class="elsevierStyleCrossRef" href="#bib46">46</a>, idiopathic pulmonary fibrosis <a class="elsevierStyleCrossRef" href="#bib47">47</a>,<a class="elsevierStyleCrossRef" href="#bib48">48</a> and liver fibrosis <a class="elsevierStyleCrossRef" href="#bib49">49</a>. These relationships indicate that this molecule may also be involved in the pathogenesis of other fibrosing diseases. Interestingly, Altrock et al. showed that blocking FN deposition using an FN assembly inhibitor (pUR4) resulted in decreased collagen accumulation and improved liver function during liver fibrogenesis <a class="elsevierStyleCrossRef" href="#bib50">50</a>. Although only a slight increase in FN1 expression was detected in the glenohumeral capsules of the patients with adhesive capsulitis in the current study, our results suggest that FN1 may play a role in the fibrotic process. Further investigation is still necessary to understand the dynamic transcriptional regulation of FN1 that occurs within the shoulder capsule.We also observed that the expression of TGFβR1 mRNA in the capsule was directly correlated with symptom duration in the patients with adhesive capsulitis. To the best of our knowledge, only one previous study has evaluated the role of the TGFβ receptor in adhesive capsulitis <a class="elsevierStyleCrossRef" href="#bib5">5</a>. Rodeo et al. analyzed both TGFβ and its receptor in capsule and synovium samples collected from patients with adhesive capsulitis and in those collected from controls <a class="elsevierStyleCrossRef" href="#bib5">5</a>. They performed a semi-quantitative analysis by comparing the frequency of positive staining between the groups. The authors described that the synovial and capsular cells of patients with adhesive capsulitis and synovitis showed clear TGFβ and TGFβR staining, whereas no or minimal staining was observed in the normal tissue specimens. The blood vessels of the affected tissues also presented staining for both proteins. Moreover, there was a higher frequency of positive TGFβ and TGFβR staining in the synovial cells of the patients with adhesive capsulitis. In addition, there was a greater frequency of positive TGFβ staining in the ECMs of patients with adhesive capsulitis compared to the controls, particularly in the capsule tissue.In the present study, we found no differences in the expression of TGFβ1 and TGFβR1 mRNA between the cases and the controls. Because the synovium is adhered to the capsule and cannot be separated from the capsule using arthroscopic instruments, our investigation did not discriminate between gene expression in synovial and capsular tissues. However, molecular alterations in both tissues are important in adhesive capsulitis <a class="elsevierStyleCrossRef" href="#bib51">51</a>. In addition, our study is the first to use a quantitative approach to evaluate the role of TGFβR1 in adhesive capsulitis. Our results suggest that TGFβR1 may have a role in adhesive capsulitis, especially in the long-term disease.To the best of our knowledge, this study is the first to quantify TGFβ1, TGFβR1, LOX, PLOD1, PLOD2, COMP, FN1, TNC and TNXB mRNA expression in the shoulder capsules of patients with adhesive capsulitis. However, this study has some limitations. First, few patients with adhesive capsulitis are surgically treated; as such, there is a limited number of tissue samples available for studies of gene expression <a class="elsevierStyleCrossRef" href="#bib5">5</a>,<a class="elsevierStyleCrossRef" href="#bib35">35</a>,<a class="elsevierStyleCrossRefs" href="#bib52">52-59</a>. Therefore, some of our statistical analyses had reduced power to detect significant differences between the studied groups and false-negative results may have occurred. Second, we included patients who failed in conservative treatment in different phases of frozen shoulder, some in freezing and others in frozen stages. This heterogeneity may have also contributed to false negatives. Third, molecular alterations may occur in other capsule regions and may have a different etiological role in capsular injury <a class="elsevierStyleCrossRefs" href="#bib30">30-32</a>. We evaluated the AI region because this portion of the capsule presented macroscopic injuries (i.e., a high level of inflammation) during arthroscopic examination of the studied patients. Although we did not detect a correlation between age and gene expression in the tissue samples collected from the patients with adhesive capsulitis, it is important to highlight that the age distribution between the patients and the controls was different. Thus, we cannot exclude that age might have influenced our findings. Finally, additional analysis of the protein products of the studied genes may be interesting because protein function is also affected by post-transcriptional and post-translational regulation.Elevated expression of TNC and FN1 mRNA may be a marker of capsule injury and may be involved in capsule inflammation and fibrosis. Upregulation of TGFβR1 seems to be related to symptom duration in adhesive capsulitis; therefore, TGFβ signaling may play a role in this condition.AUTHOR CONTRIBUTIONSCohen C, Leal MF, Smith MC, Ejnisman B and Faloppa F conceived and designed the experiments. Cohen C, Belangero PS, Figueiredo EA, Andreoli CV, Pochini AC and Ejnisman B were involved in data collection. Cohen C, Belangero PS, Figueiredo EA, Figueiredo EA, Pochini AC and Ejnisman B were responsible for sample collection. Leal MF was involved in the genetic analysis. Cohen C, Leal MF, Belangero PS and Figueiredo EA performed the literature search. Leal MF and Smith MC were involved in data and statistical analyses. Cohen C and Leal MF wrote the first draft of the manuscript. All authors listed have contributed to all subsequent drafts and all have approved the final manuscript." "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xpalclavsec1580457" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "MATERIALS AND METHODS" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Patients" ] 1 => array:2 [ "identificador" => "cesec40" "titulo" => "Tissue samples" ] 2 => array:2 [ "identificador" => "cesec50" "titulo" => "RNA extraction" ] 3 => array:2 [ "identificador" => "cesec60" "titulo" => "mRNA expression analysis" ] 4 => array:2 [ "identificador" => "cesec70" "titulo" => "Statistical analysis" ] ] ] 3 => array:3 [ "identificador" => "cesec80" "titulo" => "RESULTS" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "cesec90" "titulo" => "Differences between cases and controls" ] 1 => array:2 [ "identificador" => "cesec100" "titulo" => "Associations between the clinical characteristics of adhesive capsulitis and mRNA expression" ] ] ] 4 => array:2 [ "identificador" => "cesec110" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec120" "titulo" => "AUTHOR CONTRIBUTIONS" ] 6 => array:2 [ "identificador" => "xack638307" "titulo" => "ACKNOWLEDGMENTS" ] 7 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-12-15" "fechaAceptado" => "2016-03-21" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1580457" "palabras" => array:5 [ 0 => "Adhesive Capsulitis" 1 => "Glenohumeral Capsule" 2 => "Gene Expression" 3 => "Extracellular Matrix" 4 => "TGFβ1 Signaling" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "OBJECTIVES:We evaluated mRNA expression levels of genes that encode TGF-β1; the TGF-β1 receptor; the collagen-modifying enzymes LOX, PLOD1, and PLOD2; and the extracellular matrix proteins COMP, FN1, TNC and TNXB in synovial/capsule specimens from patients with idiopathic adhesive capsulitis. Possible associations between the measured mRNA levels and clinical parameters were also investigated. METHODS:We obtained glenohumeral joint synovium/capsule specimens from 9 patients with idiopathic adhesive capsulitis who had not shown improvement in symptoms after 5 months of physiotherapy. Adhesive capsulitis was confirmed in all patients by magnetic resonance imaging. We also obtained specimens from 8 control patients who had underwent surgery for acute acromioclavicular joint dislocation and who had radiological indication of glenohumeral capsule alteration based on arthroscopic evaluation. mRNA expression in the synovium/capsule specimens was analyzed by quantitative reverse transcription PCR. The B2M and HPRT1 genes were used as references to normalize target gene expression in the shoulder tissue samples. RESULTS:The synovium/capsule samples from the patients with adhesive capsulitis had significantly higher TNC and FN1 expression than those from the controls. Additionally, symptom duration directly correlated with expression of TGFβ1 receptor I. CONCLUSION:Elevated levels of TNC and FN1 expression may be a marker of capsule injury. Upregulation of TGFβ1 receptor I seems to be dependent on symptom duration; therefore, TGFβ signaling may be involved in adhesive capsulitis. As such, TNC, FN1 and TGFβ1 receptor I may also play roles in adhesive capsulitis by contributing to capsule inflammation and fibrosis." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVES:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "METHODS:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "RESULTS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "CONCLUSION:" ] ] ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "No potential conflict of interest was reported." ] ] "multimedia" => array:5 [ 0 => array:7 [ "identificador" => "fig1-cln_71p325" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "cln-71-06-325-g001.jpeg" "Alto" => 264 "Ancho" => 800 "Tamanyo" => 28265 ] ] "descripcion" => array:1 [ "en" => "TNC (A) and FN1 (B) expression levels in capsule samples collected from patients with adhesive capsulitis and controls. A lower delta cycle threshold value (ΔCrt) indicates higher gene expression. Box plots show the median and interquartile range. *A significant difference between groups by Mann-Whitney test (p <0.05)." ] ] 1 => array:7 [ "identificador" => "fig2-cln_71p325" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "cln-71-06-325-g002.jpeg" "Alto" => 617 "Ancho" => 800 "Tamanyo" => 52674 ] ] "descripcion" => array:1 [ "en" => "Correlation between gene expression and duration of adhesive capsulitis (months). A) TGFβ1; B) TGFβR1; C) LOX; D) PLOD1; E) PLOD2; F) COMP; G) FN1; H) TNC; and I) TNXB. ρ: Spearman correlation coefficient (“rho”). *Significant correlation (p<0.05). A lower delta cycle threshold value (ΔCrt) indicates higher gene expression." ] ] 2 => array:7 [ "identificador" => "t1-cln_71p325" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "N: number of patients; IQR: interquartile range." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Variable \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Distribution \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age at surgery, years [median (IQR)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">51.7 (16.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Age at symptom onset, years [median (IQR)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">50.4 (14.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Gender [N(%)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Male \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (33) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Female \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (67) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Duration of condition, months [median (IQR)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">10.67 (10) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Bilaterality [N(%)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (67) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (33) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Practice of sports involving the upper limbs [N (%)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">No \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 (89) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Yes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (11) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Type of job [N(%)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-manual \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">6 (67) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Manual \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3 (33) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Smoking habits [N(%)] \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Non-smoker \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">8 (89) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Smoker \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1 (11) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Distribution of clinical variables for patients with adhesive capsulitis." ] ] 3 => array:7 [ "identificador" => "t2-cln_71p325" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Gene symbol \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Name \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Assay<a class="elsevierStyleCrossRef" href="#tfn2-cln_71p325">*</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TGFβ1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Transforming growth factor, beta 1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hs00998133_m1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TGFβR1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Transforming growth factor, beta receptor 1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hs00610320_m1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LOX \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lysyl oxidase \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hs00942480_m1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PLOD1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lysyl hydroxylases 1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hs00609368_m1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PLOD2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Lysyl hydroxylases 2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hs01118190_m1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">COMP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cartilage oligomeric matrix protein \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hs00164359_m1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FN1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fibronectin 1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hs00365052_m1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TNC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tenascin C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hs01115665_m1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TNXB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Tenascin XB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hs00372889_g1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">B2M<a class="elsevierStyleCrossRef" href="#tfn3-cln_71p325">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Beta-2-microglobulin \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hs00984230_m1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">HPRT1<a class="elsevierStyleCrossRef" href="#tfn3-cln_71p325">**</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hypoxanthine phosphoribosyl-transferase \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Hs02800695_m1 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tfn2-cln_71p325" "etiqueta" => "*" "nota" => "TaqMan probes were purchased as assay-on-demand products for gene expression (Life Technologies, USA)." ] 1 => array:3 [ "identificador" => "tfn3-cln_71p325" "etiqueta" => "**" "nota" => "Reference genes for target gene expression normalization." ] ] ] "descripcion" => array:1 [ "en" => "Summary of reference gene and target gene assays." ] ] 4 => array:7 [ "identificador" => "t3-cln_71p325" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Gene \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Cases [ΔCrt; Median (IQR)] \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Controls [ΔCrt; Median (IQR)] \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">p-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TGFβ1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.99 (0.62) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.57 (0.52) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.149 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TGFβR1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.77 (1.04) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.47 (0.73) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.923 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LOX \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.16 (2.27) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.37 (1.52) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.700 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PLOD1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.95 (0.62) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.07 (0.48) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.336 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">PLOD2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.39 (0.82) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.11 (1.08) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.068 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">COMP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1.39 (3.53) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-0.01 (2.05) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.336 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FN1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-5.65 (1.53) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-4.85 (0.79) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.043<a class="elsevierStyleCrossRef" href="#tfn4-cln_71p325">*</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TNC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-1.48 (1.72) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.36 (1.31) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.005<a class="elsevierStyleCrossRef" href="#tfn4-cln_71p325">*</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">TNXB \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-2.55 (1.02) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">-2.79 (1.03) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t">0.290 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tfn4-cln_71p325" "etiqueta" => "*" "nota" => "Significant difference between groups by Mann-Whitney test (p<0.05). IQR: interquartile range. A lower delta cycle threshold value (ΔCrt) indicates higher gene expression." ] ] ] "descripcion" => array:1 [ "en" => "Gene expression patterns in the glenohumeral capsules of patients with adhesive capsulitis and in controls." ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:59 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnosis and management of adhesive capsulitis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ RC Manske \n \t\t\t\t\t\t\t\t """ 1 => """ D Prohaska \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s12178-008-9031-6" "Revista" => array:7 [ "tituloSerie" => "Curr Rev Musculoskelet Med" "fecha" => "2008" "volumen" => "1" "numero" => "3-4" "paginaInicial" => "180" "paginaFinal" => "189" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19468904" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s12178-008-9031-6" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/s12178-008-9031-6" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary frozen shoulder: brief review of pathology and imaging abnormalities" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ K Tamai \n \t\t\t\t\t\t\t\t """ 1 => """ M Akutsu \n \t\t\t\t\t\t\t\t """ 2 => """ Y Yano \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s00776-013-0495-x" "Revista" => array:7 [ "tituloSerie" => "J Orthop Sci" "fecha" => "2014" "volumen" => "19" "numero" => "1" "paginaInicial" => "1" "paginaFinal" => "5" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24306579" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s00776-013-0495-x" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/s00776-013-0495-x" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The pathology of frozen shoulder" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ GC Hand \n \t\t\t\t\t\t\t\t """ 1 => """ NA Athanasou \n \t\t\t\t\t\t\t\t """ 2 => """ T Matthews \n \t\t\t\t\t\t\t\t """ 3 => """ AJ Carr \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1302/0301-620X.89B7.19097" "Revista" => array:7 [ "tituloSerie" => "J Bone Joint Surg Br" "fecha" => "2007" "volumen" => "89" "numero" => "7" "paginaInicial" => "928" "paginaFinal" => "932" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17673588" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1302/0301-620X.89B7.19097" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1302/0301-620X.89B7.19097" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The pathology of frozen shoulder. A Dupuytren-like disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ TD Bunker \n \t\t\t\t\t\t\t\t """ 1 => """ PP Anthony \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "J Bone Joint Surg Br" "fecha" => "1995" "volumen" => "77" "numero" => "5" "paginaInicial" => "677" "paginaFinal" => "683" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7559688" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Immunolocalization of cytokines and their receptors in adhesive capsulitis of the shoulder" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ SA Rodeo \n \t\t\t\t\t\t\t\t """ 1 => """ JA Hannafin \n \t\t\t\t\t\t\t\t """ 2 => """ J Tom \n \t\t\t\t\t\t\t\t """ 3 => """ RF Warren \n \t\t\t\t\t\t\t\t """ 4 => """ TL Wickiewicz \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1002/jor.1100150316" "Revista" => array:7 [ "tituloSerie" => "J Orthop Res" "fecha" => "1997" "volumen" => "15" "numero" => "3" "paginaInicial" => "427" "paginaFinal" => "436" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9246090" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1002/jor.1100150316" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1002/jor.1100150316" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytokines and human fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ EC LeRoy \n \t\t\t\t\t\t\t\t """ 1 => """ MI Trojanowska \n \t\t\t\t\t\t\t\t """ 2 => """ EA Smith \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Eur Cytokine Netw" "fecha" => "1990" "volumen" => "1" "numero" => "4" "paginaInicial" => "215" "paginaFinal" => "219" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1966552" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transforming growth factor-beta (TGF-beta)" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ DA Clark \n \t\t\t\t\t\t\t\t """ 1 => """ R Coker \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/s1357-2725(97)00128-3" "Revista" => array:7 [ "tituloSerie" => "Int J Biochem Cell Biol" "fecha" => "1998" "volumen" => "30" "numero" => "3" "paginaInicial" => "293" "paginaFinal" => "298" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9611771" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/s1357-2725(97)00128-3" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/S1357-2725(97)00128-3" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanism of activation of the TGF-beta receptor" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ JL Wrana \n \t\t\t\t\t\t\t\t """ 1 => """ L Attisano \n \t\t\t\t\t\t\t\t """ 2 => """ R Wieser \n \t\t\t\t\t\t\t\t """ 3 => """ F Ventura \n \t\t\t\t\t\t\t\t """ 4 => """ J Massague \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1038/370341a0" "Revista" => array:7 [ "tituloSerie" => "Nature" "fecha" => "1994" "volumen" => "370" "numero" => "6488" "paginaInicial" => "341" "paginaFinal" => "347" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8047140" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1038/370341a0" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1038/370341a0" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TGFBR1 signaling and breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ L Moore-Smith \n \t\t\t\t\t\t\t\t """ 1 => """ B Pasche \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s10911-011-9216-2" "Revista" => array:7 [ "tituloSerie" => "J Mammary Gland Biol Neoplasia" "fecha" => "2011" "volumen" => "16" "numero" => "2" "paginaInicial" => "89" "paginaFinal" => "95" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21461994" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s10911-011-9216-2" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/s10911-011-9216-2" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differences in cellular properties and responses to growth factors between human ACL and MCL cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ M Yoshida \n \t\t\t\t\t\t\t\t """ 1 => """ K Fujii \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s007760050106" "Revista" => array:7 [ "tituloSerie" => "J Orthop Sci" "fecha" => "1999" "volumen" => "4" "numero" => "4" "paginaInicial" => "293" "paginaFinal" => "298" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10436277" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s007760050106" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/s007760050106" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Differential effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on gene expression of collagen-modifying enzymes in human adipose tissue-derived mesenchymal stem cells" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ M Knippenberg \n \t\t\t\t\t\t\t\t """ 1 => """ MN Helder \n \t\t\t\t\t\t\t\t """ 2 => """ BZ Doulabi \n \t\t\t\t\t\t\t\t """ 3 => """ RA Bank \n \t\t\t\t\t\t\t\t """ 4 => """ PI Wuisman \n \t\t\t\t\t\t\t\t """ 5 => """ J Klein-Nulend \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1089/ten.tea.2007.0184" "Revista" => array:7 [ "tituloSerie" => "Tissue Eng Part A" "fecha" => "2009" "volumen" => "15" "numero" => "8" "paginaInicial" => "2213" "paginaFinal" => "2225" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19231972" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1089/ten.tea.2007.0184" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1089/ten.tea.2007.0184" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "TGF-ss induces Lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ DF Remst \n \t\t\t\t\t\t\t\t """ 1 => """ EN Blaney Davidson \n \t\t\t\t\t\t\t\t """ 2 => """ EL Vitters \n \t\t\t\t\t\t\t\t """ 3 => """ RA Bank \n \t\t\t\t\t\t\t\t """ 4 => """ WB van den Berg \n \t\t\t\t\t\t\t\t """ 5 => """ PM van der Kraan \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s00441-013-1740-5" "Revista" => array:7 [ "tituloSerie" => "Cell Tissue Res" "fecha" => "2014" "volumen" => "355" "numero" => "1" "paginaInicial" => "163" "paginaFinal" => "171" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24192939" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s00441-013-1740-5" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/s00441-013-1740-5" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ TJ Witsch \n \t\t\t\t\t\t\t\t """ 1 => """ P Turowski \n \t\t\t\t\t\t\t\t """ 2 => """ E Sakkas \n \t\t\t\t\t\t\t\t """ 3 => """ G Niess \n \t\t\t\t\t\t\t\t """ 4 => """ S Becker \n \t\t\t\t\t\t\t\t """ 5 => """ S Herold \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1152/ajplung.00109.2013" "Revista" => array:7 [ "tituloSerie" => "Am J Physiol Lung Cell Mol Physiol" "fecha" => "2014" "volumen" => "306" "numero" => "3" "paginaInicial" => "L246" "paginaFinal" => "L259" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24285264" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1152/ajplung.00109.2013" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1152/ajplung.00109.2013" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lysyl oxidase: properties, regulation and multiple functions in biology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ LI Smith-Mungo \n \t\t\t\t\t\t\t\t """ 1 => """ HM Kagan \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/s0945-053x(98)90012-9" "Revista" => array:7 [ "tituloSerie" => "Matrix Biol" "fecha" => "1998" "volumen" => "16" "numero" => "7" "paginaInicial" => "387" "paginaFinal" => "398" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9524359" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/s0945-053x(98)90012-9" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/S0945-053X(98)90012-9" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ HM Kagan \n \t\t\t\t\t\t\t\t """ 1 => """ W Li \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1002/jcb.10413" "Revista" => array:7 [ "tituloSerie" => "J Cell Biochem" "fecha" => "2003" "volumen" => "88" "numero" => "4" "paginaInicial" => "660" "paginaFinal" => "672" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12577300" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1002/jcb.10413" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1002/jcb.10413" ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expanding the lysyl hydroxylase toolbox: new insights into the localization and activities of lysyl hydroxylase 3 (LH3)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ R Myllyla \n \t\t\t\t\t\t\t\t """ 1 => """ C Wang \n \t\t\t\t\t\t\t\t """ 2 => """ J Heikkinen \n \t\t\t\t\t\t\t\t """ 3 => """ A Juffer \n \t\t\t\t\t\t\t\t """ 4 => """ O Lampela \n \t\t\t\t\t\t\t\t """ 5 => """ M Risteli \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1002/jcp.21036" "Revista" => array:7 [ "tituloSerie" => "J Cell Physiol" "fecha" => "2007" "volumen" => "212" "numero" => "2" "paginaInicial" => "323" "paginaFinal" => "329" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17516569" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1002/jcp.21036" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1002/jcp.21036" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Quantitation of hydroxypyridinium crosslinks in collagen by high-performance liquid chromatography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ DR Eyre \n \t\t\t\t\t\t\t\t """ 1 => """ TJ Koob \n \t\t\t\t\t\t\t\t """ 2 => """ KP Van Ness \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/0003-2697(84)90101-5" "Revista" => array:7 [ "tituloSerie" => "Anal Biochem" "fecha" => "1984" "volumen" => "137" "numero" => "2" "paginaInicial" => "380" "paginaFinal" => "388" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6731820" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/0003-2697(84)90101-5" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/0003-2697&(84)90101-5" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ AJ van der Slot \n \t\t\t\t\t\t\t\t """ 1 => """ AM Zuurmond \n \t\t\t\t\t\t\t\t """ 2 => """ AJ van den Bogaerdt \n \t\t\t\t\t\t\t\t """ 3 => """ MM Ulrich \n \t\t\t\t\t\t\t\t """ 4 => """ E Middelkoop \n \t\t\t\t\t\t\t\t """ 5 => """ W Boers \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.matbio.2004.06.001" "Revista" => array:7 [ "tituloSerie" => "Matrix Biol" "fecha" => "2004" "volumen" => "23" "numero" => "4" "paginaInicial" => "251" "paginaFinal" => "257" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15296939" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.matbio.2004.06.001" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/j.matbio.2004.06.001" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ K Rosenberg \n \t\t\t\t\t\t\t\t """ 1 => """ H Olsson \n \t\t\t\t\t\t\t\t """ 2 => """ M Morgelin \n \t\t\t\t\t\t\t\t """ 3 => """ D Heinegard \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1074/jbc.273.32.20397" "Revista" => array:7 [ "tituloSerie" => "J Biol Chem" "fecha" => "1998" "volumen" => "273" "numero" => "32" "paginaInicial" => "20397" "paginaFinal" => "20403" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9685393" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1074/jbc.273.32.20397" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1074/jbc.273.32.20397" ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enhanced activity of transforming growth factor beta1 (TGF-beta1) bound to cartilage oligomeric matrix protein" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ DR Haudenschild \n \t\t\t\t\t\t\t\t """ 1 => """ E Hong \n \t\t\t\t\t\t\t\t """ 2 => """ JH Yik \n \t\t\t\t\t\t\t\t """ 3 => """ B Chromy \n \t\t\t\t\t\t\t\t """ 4 => """ M Morgelin \n \t\t\t\t\t\t\t\t """ 5 => """ KD Snow \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1074/jbc.M111.234716" "Revista" => array:7 [ "tituloSerie" => "J Biol Chem" "fecha" => "2011" "volumen" => "286" "numero" => "50" "paginaInicial" => "43250" "paginaFinal" => "43258" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21940632" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1074/jbc.M111.234716" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1074/jbc.M111.234716" ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cartilage oligomeric matrix protein is overexpressed by scleroderma dermal fibroblasts" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ G Farina \n \t\t\t\t\t\t\t\t """ 1 => """ R Lemaire \n \t\t\t\t\t\t\t\t """ 2 => """ JH Korn \n \t\t\t\t\t\t\t\t """ 3 => """ RL Widom \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.matbio.2006.01.007" "Revista" => array:7 [ "tituloSerie" => "Matrix Biol" "fecha" => "2006" "volumen" => "25" "numero" => "4" "paginaInicial" => "213" "paginaFinal" => "222" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16520029" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.matbio.2006.01.007" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/j.matbio.2006.01.007" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Extracellular matrix: from atomic resolution to ultrastructure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ I Vakonakis \n \t\t\t\t\t\t\t\t """ 1 => """ ID Campbell \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.ceb.2007.09.005" "Revista" => array:7 [ "tituloSerie" => "Curr Opin Cell Biol" "fecha" => "2007" "volumen" => "19" "numero" => "5" "paginaInicial" => "578" "paginaFinal" => "583" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17942296" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.ceb.2007.09.005" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/j.ceb.2007.09.005" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ SL Dallas \n \t\t\t\t\t\t\t\t """ 1 => """ P Sivakumar \n \t\t\t\t\t\t\t\t """ 2 => """ CJ Jones \n \t\t\t\t\t\t\t\t """ 3 => """ Q Chen \n \t\t\t\t\t\t\t\t """ 4 => """ DM Peters \n \t\t\t\t\t\t\t\t """ 5 => """ DF Mosher \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1074/jbc.M410762200" "Revista" => array:7 [ "tituloSerie" => "J Biol Chem" "fecha" => "2005" "volumen" => "280" "numero" => "19" "paginaInicial" => "18871" "paginaFinal" => "18880" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15677465" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1074/jbc.M410762200" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1074/jbc.M410762200" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dupuytren's contracture: an update of biomolecular aspects and therapeutic perspectives" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ A Cordova \n \t\t\t\t\t\t\t\t """ 1 => """ M Tripoli \n \t\t\t\t\t\t\t\t """ 2 => """ B Corradino \n \t\t\t\t\t\t\t\t """ 3 => """ P Napoli \n \t\t\t\t\t\t\t\t """ 4 => """ F Moschella \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.jhsb.2005.07.002" "Revista" => array:7 [ "tituloSerie" => "J Hand Surg Br" "fecha" => "2005" "volumen" => "30" "numero" => "6" "paginaInicial" => "557" "paginaFinal" => "562" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16168532" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.jhsb.2005.07.002" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/j.jhsb.2005.07.002" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Joint hypermobility syndromes: the pathophysiologic role of tenascin-X gene defects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ MC Zweers \n \t\t\t\t\t\t\t\t """ 1 => """ AJ Hakim \n \t\t\t\t\t\t\t\t """ 2 => """ R Grahame \n \t\t\t\t\t\t\t\t """ 3 => """ J Schalkwijk \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1002/art.20488" "Revista" => array:7 [ "tituloSerie" => "Arthritis Rheum" "fecha" => "2004" "volumen" => "50" "numero" => "9" "paginaInicial" => "2742" "paginaFinal" => "2749" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15457441" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1002/art.20488" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1002/art.20488" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tenascin-C deficiency attenuates TGF-ss-mediated fibrosis following murine lung injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ WA Carey \n \t\t\t\t\t\t\t\t """ 1 => """ GD Taylor \n \t\t\t\t\t\t\t\t """ 2 => """ WB Dean \n \t\t\t\t\t\t\t\t """ 3 => """ JD Bristow \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1152/ajplung.00385.2009" "Revista" => array:7 [ "tituloSerie" => "Am J Physiol Lung Cell Mol Physiol" "fecha" => "2010" "volumen" => "299" "numero" => "6" "paginaInicial" => "L785" "paginaFinal" => "L793" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20833777" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1152/ajplung.00385.2009" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1152/ajplung.00385.2009" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tenascins and the importance of adhesion modulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ R Chiquet-Ehrismann \n \t\t\t\t\t\t\t\t """ 1 => """ RP Tucker \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Cold Spring Harb Perspect Biol" "fecha" => "2011" "volumen" => "3" "numero" => "5" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1101/cshperspect.a004960" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ JR Mao \n \t\t\t\t\t\t\t\t """ 1 => """ G Taylor \n \t\t\t\t\t\t\t\t """ 2 => """ WB Dean \n \t\t\t\t\t\t\t\t """ 3 => """ DR Wagner \n \t\t\t\t\t\t\t\t """ 4 => """ V Afzal \n \t\t\t\t\t\t\t\t """ 5 => """ JC Lotz \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1038/ng850" "Revista" => array:7 [ "tituloSerie" => "Nat Genet" "fecha" => "2002" "volumen" => "30" "numero" => "4" "paginaInicial" => "421" "paginaFinal" => "425" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11925569" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1038/ng850" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1038/ng850" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tenascin-X: beyond the architectural function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ U Valcourt \n \t\t\t\t\t\t\t\t """ 1 => """ LB Alcaraz \n \t\t\t\t\t\t\t\t """ 2 => """ JY Exposito \n \t\t\t\t\t\t\t\t """ 3 => """ C Lethias \n \t\t\t\t\t\t\t\t """ 4 => """ L Bartholin \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.4161/19336918.2014.994893" "Revista" => array:7 [ "tituloSerie" => "Cell Adh Migr" "fecha" => "2015" "volumen" => "9" "numero" => "1-2" "paginaInicial" => "154" "paginaFinal" => "165" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25793578" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.4161/19336918.2014.994893" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.4161/19336918.2014.994893" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression analysis of genes involved in collagen cross-linking and its regulation in traumatic anterior shoulder instability" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ PS Belangero \n \t\t\t\t\t\t\t\t """ 1 => """ MF Leal \n \t\t\t\t\t\t\t\t """ 2 => """ C Cohen \n \t\t\t\t\t\t\t\t """ 3 => """ EA Figueiredo \n \t\t\t\t\t\t\t\t """ 4 => """ MC Smith \n \t\t\t\t\t\t\t\t """ 5 => """ CV Andreoli \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "J Orthop Res" "fecha" => "2015" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1002/jor.22984" ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Profile of collagen gene expression in the glenohumeral capsule of patients with traumatic anterior instability of the shoulder" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ PS Belangero \n \t\t\t\t\t\t\t\t """ 1 => """ MF Leal \n \t\t\t\t\t\t\t\t """ 2 => """ A de Castro Pochini \n \t\t\t\t\t\t\t\t """ 3 => """ CV Andreoli \n \t\t\t\t\t\t\t\t """ 4 => """ B Ejnisman \n \t\t\t\t\t\t\t\t """ 5 => """ M Cohen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.rboe.2014.10.008" "Revista" => array:7 [ "tituloSerie" => "Rev Bras Ortop" "fecha" => "2014" "volumen" => "49" "numero" => "6" "paginaInicial" => "642" "paginaFinal" => "646" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26229875" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.rboe.2014.10.008" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/j.rbo.2013.10.012" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Gene expression analysis in patients with traumatic anterior shoulder instability suggests deregulation of collagen genes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ PS Belangero \n \t\t\t\t\t\t\t\t """ 1 => """ MF Leal \n \t\t\t\t\t\t\t\t """ 2 => """ EA Figueiredo \n \t\t\t\t\t\t\t\t """ 3 => """ C Cohen \n \t\t\t\t\t\t\t\t """ 4 => """ C Pochini Ade \n \t\t\t\t\t\t\t\t """ 5 => """ MC Smith \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1002/jor.22680" "Revista" => array:7 [ "tituloSerie" => "J Orthop Res" "fecha" => "2014" "volumen" => "32" "numero" => "10" "paginaInicial" => "1311" "paginaFinal" => "1316" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25042113" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1002/jor.22680" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1002/jor.22680" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Identification of suitable reference genes for gene expression studies of shoulder instability" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ MF Leal \n \t\t\t\t\t\t\t\t """ 1 => """ PS Belangero \n \t\t\t\t\t\t\t\t """ 2 => """ C Cohen \n \t\t\t\t\t\t\t\t """ 3 => """ EA Figueiredo \n \t\t\t\t\t\t\t\t """ 4 => """ LC Loyola \n \t\t\t\t\t\t\t\t """ 5 => """ AC Pochini \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "PloS One" "fecha" => "2014" "volumen" => "9" "numero" => "8" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1371/journal.pone.0105002" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Arthroscopic capsular release for the treatment of refractory postoperative or post-fracture shoulder stiffness" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ GB Holloway \n \t\t\t\t\t\t\t\t """ 1 => """ T Schenk \n \t\t\t\t\t\t\t\t """ 2 => """ GR Williams \n \t\t\t\t\t\t\t\t """ 3 => """ ML Ramsey \n \t\t\t\t\t\t\t\t """ 4 => """ JP Iannotti \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "J Bone Joint Surg Am" "fecha" => "2001" "volumen" => "83-A" "numero" => "11" "paginaInicial" => "1682" "paginaFinal" => "1687" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Coexistence of fibrotic and chondrogenic process in the capsule of idiopathic frozen shoulders" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ Y Hagiwara \n \t\t\t\t\t\t\t\t """ 1 => """ A Ando \n \t\t\t\t\t\t\t\t """ 2 => """ Y Onoda \n \t\t\t\t\t\t\t\t """ 3 => """ T Takemura \n \t\t\t\t\t\t\t\t """ 4 => """ T Minowa \n \t\t\t\t\t\t\t\t """ 5 => """ N Hanagata \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.joca.2011.12.008" "Revista" => array:7 [ "tituloSerie" => "Osteoarthritis Cartilage" "fecha" => "2012" "volumen" => "20" "numero" => "3" "paginaInicial" => "241" "paginaFinal" => "249" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22233812" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.joca.2011.12.008" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/j.joca.2011.12.008" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tenascin-C and human tendon degeneration" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ GP Riley \n \t\t\t\t\t\t\t\t """ 1 => """ RL Harrall \n \t\t\t\t\t\t\t\t """ 2 => """ TE Cawston \n \t\t\t\t\t\t\t\t """ 3 => """ BL Hazleman \n \t\t\t\t\t\t\t\t """ 4 => """ EJ Mackie \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Am J Pathol" "fecha" => "1996" "volumen" => "149" "numero" => "3" "paginaInicial" => "933" "paginaFinal" => "943" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8780397" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Involvement of the subacromial bursa in impingement syndrome of the shoulder as judged by expression of tenascin-C and histopathology" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ P Hyvonen \n \t\t\t\t\t\t\t\t """ 1 => """ J Melkko \n \t\t\t\t\t\t\t\t """ 2 => """ VP Lehto \n \t\t\t\t\t\t\t\t """ 3 => """ P Jalovaara \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1302/0301-620x.85b2.13124" "Revista" => array:7 [ "tituloSerie" => "J Bone Joint Surg Br" "fecha" => "2003" "volumen" => "85" "numero" => "2" "paginaInicial" => "299" "paginaFinal" => "305" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12678373" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1302/0301-620x.85b2.13124" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1302/0301-620X.85B2.13124" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regulation of fibroblast migration by tenascin-C" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ A Trebaul \n \t\t\t\t\t\t\t\t """ 1 => """ EK Chan \n \t\t\t\t\t\t\t\t """ 2 => """ KS Midwood \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1042/BST0350695" "Revista" => array:7 [ "tituloSerie" => "Biochem Soc Trans" "fecha" => "2007" "volumen" => "35" "numero" => "Pt 4" "paginaInicial" => "695" "paginaFinal" => "697" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17635125" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1042/BST0350695" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1042/BST0350695" ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reparative capacity of airway epithelium impacts deposition and remodeling of extracellular matrix" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ JC Snyder \n \t\t\t\t\t\t\t\t """ 1 => """ AC Zemke \n \t\t\t\t\t\t\t\t """ 2 => """ BR Stripp \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1165/rcmb.2008-0334OC" "Revista" => array:7 [ "tituloSerie" => "Am J Respir Cell Mol Biol" "fecha" => "2009" "volumen" => "40" "numero" => "6" "paginaInicial" => "633" "paginaFinal" => "642" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18978301" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1165/rcmb.2008-0334OC" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1165/rcmb.2008-0334OC" ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of tenascin-C in tissue injury and tumorigenesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ KS Midwood \n \t\t\t\t\t\t\t\t """ 1 => """ G Orend \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s12079-009-0075-1" "Revista" => array:7 [ "tituloSerie" => "J Cell Commun Signal" "fecha" => "2009" "volumen" => "3" "numero" => "3-4" "paginaInicial" => "287" "paginaFinal" => "310" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19838819" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s12079-009-0075-1" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/s12079-009-0075-1" ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ KE Kadler \n \t\t\t\t\t\t\t\t """ 1 => """ A Hill \n \t\t\t\t\t\t\t\t """ 2 => """ EG Canty-Laird \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.ceb.2008.06.008" "Revista" => array:7 [ "tituloSerie" => "Curr Opin Cell Biol" "fecha" => "2008" "volumen" => "20" "numero" => "5" "paginaInicial" => "495" "paginaFinal" => "501" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18640274" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.ceb.2008.06.008" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/j.ceb.2008.06.008" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EDA Fibronectin in Keloids Create a Vicious Cycle of Fibrotic Tumor Formation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ RM Kelsh \n \t\t\t\t\t\t\t\t """ 1 => """ PJ McKeown-Longo \n \t\t\t\t\t\t\t\t """ 2 => """ RA Clark \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1038/jid.2015.155" "Revista" => array:7 [ "tituloSerie" => "J Invest Dermatol" "fecha" => "2015" "volumen" => "135" "numero" => "7" "paginaInicial" => "1714" "paginaFinal" => "1718" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26066891" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1038/jid.2015.155" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1038/jid.2015.155" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ RA Ignotz \n \t\t\t\t\t\t\t\t """ 1 => """ J Massague \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "The Journal of biological chemistry" "fecha" => "1986" "volumen" => "261" "numero" => "9" "paginaInicial" => "4337" "paginaFinal" => "4345" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3456347" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Wound healing-associated proteins Hsp47 and fibronectin are elevated in Dupuytren's contracture" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ JC Howard \n \t\t\t\t\t\t\t\t """ 1 => """ VM Varallo \n \t\t\t\t\t\t\t\t """ 2 => """ DC Ross \n \t\t\t\t\t\t\t\t """ 3 => """ KJ Faber \n \t\t\t\t\t\t\t\t """ 4 => """ JH Roth \n \t\t\t\t\t\t\t\t """ 5 => """ S Seney \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.jss.2004.01.013" "Revista" => array:7 [ "tituloSerie" => "J Surg Res" "fecha" => "2004" "volumen" => "117" "numero" => "2" "paginaInicial" => "232" "paginaFinal" => "238" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15047128" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.jss.2004.01.013" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/j.jss.2004.01.013" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fibrosis, gene expression and orbital inflammatory disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ JT Rosenbaum \n \t\t\t\t\t\t\t\t """ 1 => """ D Choi \n \t\t\t\t\t\t\t\t """ 2 => """ DJ Wilson \n \t\t\t\t\t\t\t\t """ 3 => """ HE Grossniklaus \n \t\t\t\t\t\t\t\t """ 4 => """ CA Harrington \n \t\t\t\t\t\t\t\t """ 5 => """ RA Dailey \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1136/bjophthalmol-2015-306614" "Revista" => array:7 [ "tituloSerie" => "Br J Ophthalmol" "fecha" => "2015" "volumen" => "99" "numero" => "10" "paginaInicial" => "1424" "paginaFinal" => "1429" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26038391" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1136/bjophthalmol-2015-306614" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1136/bjophthalmol-2015-306614" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Fibronectin peptides as potential regulators of hepatic fibrosis through apoptosis of hepatic stellate cells" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ T Modol \n \t\t\t\t\t\t\t\t """ 1 => """ N Brice \n \t\t\t\t\t\t\t\t """ 2 => """ M Ruiz de Galarreta \n \t\t\t\t\t\t\t\t """ 3 => """ A Garcia Garzon \n \t\t\t\t\t\t\t\t """ 4 => """ MJ Iraburu \n \t\t\t\t\t\t\t\t """ 5 => """ JJ Martinez-Irujo \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1002/jcp.24714" "Revista" => array:7 [ "tituloSerie" => "Journal of cellular physiology" "fecha" => "2015" "volumen" => "230" "numero" => "3" "paginaInicial" => "546" "paginaFinal" => "553" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24976518" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1002/jcp.24714" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1002/jcp.24714" ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "In vivo co-distribution of fibronectin and actin fibers in granulation tissue: immunofluorescence and electron microscope studies of the fibronexus at the myofibroblast surface" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ DW Singer, II, Kawka \n \t\t\t\t\t\t\t\t """ 1 => """ DM Kazazis \n \t\t\t\t\t\t\t\t """ 2 => """ RA Clark \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1083/jcb.98.6.2091" "Revista" => array:7 [ "tituloSerie" => "J Cell Biol" "fecha" => "1984" "volumen" => "98" "numero" => "6" "paginaInicial" => "2091" "paginaFinal" => "2106" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6373789" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1083/jcb.98.6.2091" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1083/jcb.98.6.2091" ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Myofibroblasts exhibit enhanced fibronectin assembly that is intrinsic to their contractile phenotype" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ EE Torr \n \t\t\t\t\t\t\t\t """ 1 => """ CR Ngam \n \t\t\t\t\t\t\t\t """ 2 => """ K Bernau \n \t\t\t\t\t\t\t\t """ 3 => """ B Tomasini-Johansson \n \t\t\t\t\t\t\t\t """ 4 => """ B Acton \n \t\t\t\t\t\t\t\t """ 5 => """ N Sandbo \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1074/jbc.M114.606186" "Revista" => array:7 [ "tituloSerie" => "J Biol Chem" "fecha" => "2015 Mar 13" "volumen" => "290" "numero" => "11" "paginaInicial" => "6951" "paginaFinal" => "6961" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25627685" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1074/jbc.M114.606186" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1074/jbc.M114.606186" ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathogenesis of liver fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ V Hernandez-Gea \n \t\t\t\t\t\t\t\t """ 1 => """ SL Friedman \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1146/annurev-pathol-011110-130246" "Revista" => array:6 [ "tituloSerie" => "Annu Rev Pathol" "fecha" => "2011" "volumen" => "6" "paginaInicial" => "425" "paginaFinal" => "456" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21073339" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1146/annurev-pathol-011110-130246" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1146/annurev-pathol-011110-130246" ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhibition of fibronectin deposition improves experimental liver fibrosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ E Altrock \n \t\t\t\t\t\t\t\t """ 1 => """ C Sens \n \t\t\t\t\t\t\t\t """ 2 => """ C Wuerfel \n \t\t\t\t\t\t\t\t """ 3 => """ M Vasel \n \t\t\t\t\t\t\t\t """ 4 => """ N Kawelke \n \t\t\t\t\t\t\t\t """ 5 => """ S Dooley \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.jhep.2014.06.010" "Revista" => array:7 [ "tituloSerie" => "J Hepatol" "fecha" => "2015" "volumen" => "62" "numero" => "3" "paginaInicial" => "625" "paginaFinal" => "633" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24946284" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.jhep.2014.06.010" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/j.jhep.2014.06.010" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Frozen shoulder: A systematic review of therapeutic options" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ HS Uppal \n \t\t\t\t\t\t\t\t """ 1 => """ JP Evans \n \t\t\t\t\t\t\t\t """ 2 => """ C Smith \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.5312/wjo.v6.i2.263" "Revista" => array:7 [ "tituloSerie" => "World J Orthop" "fecha" => "2015" "volumen" => "6" "numero" => "2" "paginaInicial" => "263" "paginaFinal" => "268" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25793166" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.5312/wjo.v6.i2.263" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.5312/wjo.v6.i2.263" ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Adhesive capsulitis: human fibroblast response to shoulder joint aspirate from patients with stage II disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ H Mullett \n \t\t\t\t\t\t\t\t """ 1 => """ D Byrne \n \t\t\t\t\t\t\t\t """ 2 => """ J Colville \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.jse.2006.08.001" "Revista" => array:7 [ "tituloSerie" => "J Shoulder Elbow Surg" "fecha" => "2007" "volumen" => "16" "numero" => "3" "paginaInicial" => "290" "paginaFinal" => "294" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17240170" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.jse.2006.08.001" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/j.jse.2006.08.001" ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib53" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Enhanced expression of neuronal proteins in idiopathic frozen shoulder" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ Y Xu \n \t\t\t\t\t\t\t\t """ 1 => """ F Bonar \n \t\t\t\t\t\t\t\t """ 2 => """ GA Murrell \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.jse.2011.08.046" "Revista" => array:7 [ "tituloSerie" => "J Shoulder Elbow Surg" "fecha" => "2012" "volumen" => "21" "numero" => "10" "paginaInicial" => "1391" "paginaFinal" => "1397" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22005128" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.jse.2011.08.046" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/j.jse.2011.08.046" ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib54" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of vascular endothelial growth factor and angiogenesis in the diabetic frozen shoulder" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ JD Ryu \n \t\t\t\t\t\t\t\t """ 1 => """ PA Kirpalani \n \t\t\t\t\t\t\t\t """ 2 => """ JM Kim \n \t\t\t\t\t\t\t\t """ 3 => """ KH Nam \n \t\t\t\t\t\t\t\t """ 4 => """ CW Han \n \t\t\t\t\t\t\t\t """ 5 => """ SH Han \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons [et al" "fecha" => "2006" "volumen" => "15" "numero" => "6" "paginaInicial" => "679" "paginaFinal" => "685" ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib55" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytogenetic analysis of the pathology of frozen shoulder" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ B Kabbabe \n \t\t\t\t\t\t\t\t """ 1 => """ S Ramkumar \n \t\t\t\t\t\t\t\t """ 2 => """ M Richardson \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.4103/0973-6042.76966" "Revista" => array:7 [ "tituloSerie" => "Int J Shoulder Surg" "fecha" => "2010" "volumen" => "4" "numero" => "3" "paginaInicial" => "75" "paginaFinal" => "78" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21472067" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.4103/0973-6042.76966" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.4103/0973-6042.76966" ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib56" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inducement of mitogen-activated protein kinases in frozen shoulders" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ K Kanbe \n \t\t\t\t\t\t\t\t """ 1 => """ K Inoue \n \t\t\t\t\t\t\t\t """ 2 => """ Y Inoue \n \t\t\t\t\t\t\t\t """ 3 => """ Q Chen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s00776-008-1295-6" "Revista" => array:7 [ "tituloSerie" => "J Orthop Sci" "fecha" => "2009" "volumen" => "14" "numero" => "1" "paginaInicial" => "56" "paginaFinal" => "61" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19214689" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s00776-008-1295-6" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/s00776-008-1295-6" ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib57" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hyaluronan modulates cell proliferation and mRNA expression of adhesion-related procollagens and cytokines in glenohumeral synovial/capsular fibroblasts in adhesive capsulitis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ M Nago \n \t\t\t\t\t\t\t\t """ 1 => """ Y Mitsui \n \t\t\t\t\t\t\t\t """ 2 => """ M Gotoh \n \t\t\t\t\t\t\t\t """ 3 => """ K Nakama \n \t\t\t\t\t\t\t\t """ 4 => """ I Shirachi \n \t\t\t\t\t\t\t\t """ 5 => """ F Higuchi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1002/jor.21075" "Revista" => array:7 [ "tituloSerie" => "J Orthop Res" "fecha" => "2010" "volumen" => "28" "numero" => "6" "paginaInicial" => "726" "paginaFinal" => "731" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20058278" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1002/jor.21075" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1002/jor.21075" ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib58" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expression of growth factors, cytokines and matrix metalloproteinases in frozen shoulder" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ TD Bunker \n \t\t\t\t\t\t\t\t """ 1 => """ J Reilly \n \t\t\t\t\t\t\t\t """ 2 => """ KS Baird \n \t\t\t\t\t\t\t\t """ 3 => """ DL Hamblen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1302/0301-620x.82b5.9888" "Revista" => array:7 [ "tituloSerie" => "J Bone Joint Surg Br" "fecha" => "2000" "volumen" => "82" "numero" => "5" "paginaInicial" => "768" "paginaFinal" => "773" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10963182" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1302/0301-620x.82b5.9888" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1302/0301-620X.82B5.9888" ] ] ] ] ] ] 58 => array:3 [ "identificador" => "bib59" "etiqueta" => "59" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflammatory cytokines are overexpressed in the subacromial bursa of frozen shoulder" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ YM Lho \n \t\t\t\t\t\t\t\t """ 1 => """ E Ha \n \t\t\t\t\t\t\t\t """ 2 => """ CH Cho \n \t\t\t\t\t\t\t\t """ 3 => """ KS Song \n \t\t\t\t\t\t\t\t """ 4 => """ BW Min \n \t\t\t\t\t\t\t\t """ 5 => """ KC Bae \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.jse.2012.06.014" "Revista" => array:7 [ "tituloSerie" => "J Shoulder Elbow Surg" "fecha" => "2013" "volumen" => "22" "numero" => "5" "paginaInicial" => "666" "paginaFinal" => "672" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22999851" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.jse.2012.06.014" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/j.jse.2012.06.014" ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack638307" "titulo" => "ACKNOWLEDGMENTS" "texto" => "This study was supported by grants and fellowships from the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ; MC and MACS) and the Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP; MC and MFL). We are grateful to Sintia Iole Belangero, Ph. D, for the scientific project support." "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000007100000006/v1_202211291053/S1807593222010912/v1_202211291053/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000007100000006/v1_202211291053/S1807593222010912/v1_202211291053/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222010912?idApp=UINPBA00004N"]

Statistics

CLINICAL SCIENCE

Carina CohenI,#, Mariana Ferreira LealI,II,

,#, Paulo Santoro BelangeroI, Eduardo Antônio FigueiredoI, Marília Cardoso SmithII, Carlos Vicente AndreoliI, Alberto de Castro PochiniI, Moises CohenI, Benno EjnismanI, Flávio FaloppaI

I Universidade Federal de São Paulo, Departamento de Ortopedia e Traumatologia

II Departamento de Morfologia e Genética, Disciplina de Genética, São Paulo/SP, Brazil

Read

873

Times
was read the article

218

Total PDF

655

Total HTML

Share statistics

 array:24 [
  "pii" => "S1807593222010912"
  "issn" => "18075932"
  "doi" => "10.6061/clinics/2016(06)07"
  "estado" => "S300"
  "fechaPublicacion" => "2016-01-01"
  "aid" => "1091"
  "copyright" => "CLINICS"
  "copyrightAnyo" => "2016"
  "documento" => "article"
  "crossmark" => 0
  "licencia" => "https://creativecommons.org/licenses/by/4.0/"
  "subdocumento" => "fla"
  "cita" => "Clinics. 2016;71:325-31"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:1 [
    "total" => 0
  ]
  "itemSiguiente" => array:19 [
    "pii" => "S1807593222010924"
    "issn" => "18075932"
    "doi" => "10.6061/clinics/2016(06)08"
    "estado" => "S300"
    "fechaPublicacion" => "2016-01-01"
    "aid" => "1092"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2016;71:332-7"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:11 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>"
      "titulo" => "Reduced placental volume and flow in severe growth restricted fetuses"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "332"
          "paginaFinal" => "337"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Renata Montes Dourado Abul&#233;, Lisandra Stein Bernardes, Giovana Farina Doro, Seizo Miyadahira, Rossana Pulcinelli Vieira Francisco"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Renata Montes Dourado"
              "apellidos" => "Abul&#233;"
            ]
            1 => array:2 [
              "nombre" => "Lisandra Stein"
              "apellidos" => "Bernardes"
            ]
            2 => array:2 [
              "nombre" => "Giovana Farina"
              "apellidos" => "Doro"
            ]
            3 => array:2 [
              "nombre" => "Seizo"
              "apellidos" => "Miyadahira"
            ]
            4 => array:2 [
              "nombre" => "Rossana Pulcinelli Vieira"
              "apellidos" => "Francisco"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222010924?idApp=UINPBA00004N"
    "url" => "/18075932/0000007100000006/v1_202211291053/S1807593222010924/v1_202211291053/en/main.assets"
  ]
  "itemAnterior" => array:19 [
    "pii" => "S1807593222010900"
    "issn" => "18075932"
    "doi" => "10.6061/clinics/2016(06)06"
    "estado" => "S300"
    "fechaPublicacion" => "2016-01-01"
    "aid" => "1090"
    "copyright" => "CLINICS"
    "documento" => "article"
    "crossmark" => 0
    "licencia" => "https://creativecommons.org/licenses/by/4.0/"
    "subdocumento" => "fla"
    "cita" => "Clinics. 2016;71:320-4"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:1 [
      "total" => 0
    ]
    "en" => array:12 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>"
      "titulo" => "Application of bioabsorbable screw fixation for anterior cervical decompression and bone grafting"
      "tienePdf" => "en"
      "tieneTextoCompleto" => "en"
      "tieneResumen" => "en"
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "320"
          "paginaFinal" => "324"
        ]
      ]
      "contieneResumen" => array:1 [
        "en" => true
      ]
      "contieneTextoCompleto" => array:1 [
        "en" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "resumenGrafico" => array:2 [
        "original" => 0
        "multimedia" => array:7 [
          "identificador" => "fig2-cln_71p320"
          "etiqueta" => "Figure 2"
          "tipo" => "MULTIMEDIAFIGURA"
          "mostrarFloat" => true
          "mostrarDisplay" => false
          "figura" => array:1 [
            0 => array:4 [
              "imagen" => "cln-71-06-320-g002.jpeg"
              "Alto" => 738
              "Ancho" => 800
              "Tamanyo" => 103101
            ]
          ]
          "descripcion" => array:1 [
            "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Imaging examinations of a patient who underwent C5-7 fusion&#46; A&#58; Radiograph&#44; lateral view&#59; pre-operation&#46; B&#58; Radiograph&#44; lateral view&#59; post-operation&#46; C&#58; Computed tomography scan&#44; axial view&#59; note the poly L&#47;lactide screws &#40;arrow&#41;&#46; D&#58; Three-dimensional reconstruction of the graft&#46; E&#58; Magnetic resonance imaging scan&#44; axial view&#59; pre-operation&#46; F&#58; Magnetic resonance imaging scan&#44; axial view&#59; post-operation&#46;</p>"
          ]
        ]
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Bo Zhao, Xiaowen Qiu, Dong Wang, Haopeng Li, Xijing He"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "Bo"
              "apellidos" => "Zhao"
            ]
            1 => array:2 [
              "nombre" => "Xiaowen"
              "apellidos" => "Qiu"
            ]
            2 => array:2 [
              "nombre" => "Dong"
              "apellidos" => "Wang"
            ]
            3 => array:2 [
              "nombre" => "Haopeng"
              "apellidos" => "Li"
            ]
            4 => array:2 [
              "nombre" => "Xijing"
              "apellidos" => "He"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222010900?idApp=UINPBA00004N"
    "url" => "/18075932/0000007100000006/v1_202211291053/S1807593222010900/v1_202211291053/en/main.assets"
  ]
  "en" => array:20 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>"
    "titulo" => "The roles of Tenascin C and Fibronectin 1 in adhesive capsulitis&#58; a pilot gene expression study"
    "tieneTextoCompleto" => true
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "325"
        "paginaFinal" => "331"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "Carina Cohen, Mariana Ferreira Leal, Paulo Santoro Belangero, Eduardo Ant&#244;nio Figueiredo, Mar&#237;lia Cardoso Smith, Carlos Vicente Andreoli, Alberto de Castro Pochini, Moises Cohen, Benno Ejnisman, Fl&#225;vio Faloppa"
        "autores" => array:10 [
          0 => array:3 [
            "nombre" => "Carina"
            "apellidos" => "Cohen"
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "af1-cln_71p325"
              ]
              1 => array:2 [
                "etiqueta" => "&#35;"
                "identificador" => "c2-cln_71p325"
              ]
            ]
          ]
          1 => array:4 [
            "nombre" => "Mariana Ferreira"
            "apellidos" => "Leal"
            "email" => array:1 [
              0 => "mariana.morf@epm.br"
            ]
            "referencia" => array:4 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "af1-cln_71p325"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">II</span>"
                "identificador" => "af2-cln_71p325"
              ]
              2 => array:2 [
                "etiqueta" => "&#42;"
                "identificador" => "c1-cln_71p325"
              ]
              3 => array:2 [
                "etiqueta" => "&#35;"
                "identificador" => "c2-cln_71p325"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Paulo Santoro"
            "apellidos" => "Belangero"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "af1-cln_71p325"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Eduardo Ant&#244;nio"
            "apellidos" => "Figueiredo"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "af1-cln_71p325"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "Mar&#237;lia Cardoso"
            "apellidos" => "Smith"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">II</span>"
                "identificador" => "af2-cln_71p325"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Carlos Vicente"
            "apellidos" => "Andreoli"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "af1-cln_71p325"
              ]
            ]
          ]
          6 => array:3 [
            "nombre" => "Alberto"
            "apellidos" => "de Castro Pochini"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "af1-cln_71p325"
              ]
            ]
          ]
          7 => array:3 [
            "nombre" => "Moises"
            "apellidos" => "Cohen"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "af1-cln_71p325"
              ]
            ]
          ]
          8 => array:3 [
            "nombre" => "Benno"
            "apellidos" => "Ejnisman"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "af1-cln_71p325"
              ]
            ]
          ]
          9 => array:3 [
            "nombre" => "Fl&#225;vio"
            "apellidos" => "Faloppa"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">I</span>"
                "identificador" => "af1-cln_71p325"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:2 [
          0 => array:3 [
            "entidad" => "Universidade Federal de S&#227;o Paulo&#44; Departamento de Ortopedia e Traumatologia"
            "etiqueta" => "I"
            "identificador" => "af1-cln_71p325"
          ]
          1 => array:3 [
            "entidad" => "Departamento de Morfologia e Gen&#233;tica&#44; Disciplina de Gen&#233;tica&#44; S&#227;o Paulo&#47;SP&#44; Brazil"
            "etiqueta" => "II"
            "identificador" => "af2-cln_71p325"
          ]
        ]
      ]
    ]
    "resumenGrafico" => array:2 [
      "original" => 0
      "multimedia" => array:7 [
        "identificador" => "fig2-cln_71p325"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "cln-71-06-325-g002.jpeg"
            "Alto" => 617
            "Ancho" => 800
            "Tamanyo" => 52674
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Correlation between gene expression and duration of adhesive capsulitis &#40;months&#41;&#46; A&#41; <span class="elsevierStyleItalic">TGF&#946;1</span>&#59; B&#41; <span class="elsevierStyleItalic">TGF&#946;R1</span>&#59; C&#41; <span class="elsevierStyleItalic">LOX</span>&#59; D&#41; <span class="elsevierStyleItalic">PLOD1</span>&#59; E&#41; <span class="elsevierStyleItalic">PLOD2</span>&#59; F&#41; <span class="elsevierStyleItalic">COMP</span>&#59; G&#41; <span class="elsevierStyleItalic">FN1</span>&#59; H&#41; <span class="elsevierStyleItalic">TNC</span>&#59; and I&#41; <span class="elsevierStyleItalic">TNXB&#46;</span> &#961;&#58; Spearman correlation coefficient &#40;&#8220;rho&#8221;&#41;&#46; <span class="elsevierStyleItalic">&#42;</span>Significant correlation &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;05&#41;&#46; A lower delta cycle threshold value &#40;&#916;Crt&#41; indicates higher gene expression&#46;</p>"
        ]
      ]
    ]
    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle50">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Adhesive capsulitis&#44; or frozen shoulder&#44; is a debilitating condition in which patients present limited active and passive glenohumeral motion&#46; Adhesive capsulitis occurs in 3&#37;-5&#37; of the general population <a class="elsevierStyleCrossRef" href="#bib1">1</a> and the main cause of the painful restriction of movement is inflammatory contracture of the joint capsule&#46; The initial inflammation seems to lead to capsular fibrosis&#44; stiffness and pain <a class="elsevierStyleCrossRef" href="#bib2">2</a>&#46; Therefore&#44; it has been hypothesized that similarities exist between adhesive capsulitis and the fibrous contractures that occur in Dupuytren disease <a class="elsevierStyleCrossRef" href="#bib3">3</a>&#44;<a class="elsevierStyleCrossRef" href="#bib4">4</a>&#46; However&#44; the molecular mechanism responsible for the underlying glenohumeral capsule inflammation and fibrosis is poorly understood&#46;</p><p id="para20" class="elsevierStylePara elsevierViewall">Rodeo et al&#46; suggested that cytokines&#44; such as transforming growth factor beta &#40;TGF&#946;&#41;&#44; may be involved in the inflammatory and fibrotic processes that occur in adhesive capsulitis&#46; These cytokines may cause abnormal regulation of collagen expression and augment fibroblast proliferation <a class="elsevierStyleCrossRef" href="#bib5">5</a>&#46; Therefore&#44; TGF&#946; acts as a persistent stimulus that leads to capsular fibrosis&#46;</p><p id="para30" class="elsevierStylePara elsevierViewall">TGF&#946; induces fibroblasts to synthesize&#44; remodel and contract extracellular matrix &#40;ECM&#41;&#44; making this cytokine a key mediator of the fibrotic response <a class="elsevierStyleCrossRef" href="#bib6">6</a>&#46; TGF&#946; is activated by proteolytic cleavage <a class="elsevierStyleCrossRef" href="#bib7">7</a> mediated by the signaling receptors TGF&#946; receptor I &#40;TGF&#946;R1&#41; and TGF&#946; receptor 2 &#40;TGF&#946;R2&#41; <a class="elsevierStyleCrossRef" href="#bib8">8</a>&#46; TGFBR1 is the principal propagator of TGF&#946; signaling <a class="elsevierStyleCrossRef" href="#bib9">9</a>&#46;</p><p id="para40" class="elsevierStylePara elsevierViewall">TGF&#946;1&#44; a key member of the TGF&#946; superfamily&#44; regulates the collagen-modifying enzymes lysyl oxidase &#40;LOX&#41; <a class="elsevierStyleCrossRef" href="#bib10">10</a> and lysyl hydroxylases 1 and 2 &#40;encoded by the <span class="elsevierStyleItalic">PLOD1</span> and <span class="elsevierStyleItalic">PLOD2</span> genes&#44; respectively&#41; <a class="elsevierStyleCrossRefs" href="#bib11">11-13</a>&#46; LOX plays a role in connective tissue matrix biogenesis through the oxidation of lysine residues in collagen and elastin&#44; contributing to the formation of covalent cross-links and thereby stabilizing fibrous ECM proteins <a class="elsevierStyleCrossRef" href="#bib14">14</a>&#44;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#46; In several fibrotic injuries&#44; TGF&#946;1 controls the expression and enzymatic activity of LOX <a class="elsevierStyleCrossRef" href="#bib10">10</a>&#46;</p><p id="para50" class="elsevierStylePara elsevierViewall">Lysyl hydroxylases such as PLOD1 and PLOD2 promote cross-linking in ECM molecules&#44; which contribute to ECM structural stability and maturation <a class="elsevierStyleCrossRef" href="#bib16">16</a>&#44;<a class="elsevierStyleCrossRef" href="#bib17">17</a>&#46; Increased <span class="elsevierStyleItalic">PLOD2</span> expression has been reported in fibroblasts isolated from hypertrophic scars&#44; keloids and <span class="elsevierStyleItalic">palmar fascia</span> from patients with Dupuytren disease <a class="elsevierStyleCrossRef" href="#bib18">18</a>&#46; To the best of our knowledge&#44; no previous studies have evaluated the roles of lysyl oxidase and hydroxylase in adhesive capsulitis&#46;</p><p id="para60" class="elsevierStylePara elsevierViewall">TGF&#946; regulates and is regulated by several ECM proteins&#46; Cartilage oligomeric matrix protein &#40;COMP&#41;&#44; a glycoprotein found in the ECM of joints&#44; plays a catalytic role in fibrillogenesis <a class="elsevierStyleCrossRef" href="#bib19">19</a>&#46; Recent studies have shown that COMP also directly binds members of the TGF&#946; superfamily of proteins&#44; including TGF&#946;1 <a class="elsevierStyleCrossRef" href="#bib20">20</a>&#46; Haudenschild et al&#46; showed that TGF&#946;1 displays enhanced bioactivity when bound to COMP <a class="elsevierStyleCrossRef" href="#bib20">20</a>&#46; In addition&#44; TGF&#946;1 appears to have the capacity to induce COMP expression <a class="elsevierStyleCrossRef" href="#bib21">21</a>&#46;</p><p id="para70" class="elsevierStylePara elsevierViewall">Fibronectin &#40;FN&#41;&#44; a glycoprotein encoded by the <span class="elsevierStyleItalic">FN1</span> gene&#44; is involved in several biological processes&#44; including cell adhesion&#44; tissue development and wound healing <a class="elsevierStyleCrossRef" href="#bib22">22</a>&#46; FN also has a role in TGF&#946; regulation <a class="elsevierStyleCrossRef" href="#bib23">23</a>&#46; Moreover&#44; FN expression increases under stimuli induced by TGF&#946; <a class="elsevierStyleCrossRef" href="#bib24">24</a>&#46;</p><p id="para80" class="elsevierStylePara elsevierViewall">Moreover&#44; the tenascins &#40;TN&#41;&#44; including TNR&#44; TNC and TNX&#44; are a highly conserved family of ECM glycoproteins&#46; TNR is expressed only in the brain&#44; whereas TNC and TNX are expressed in several organs and tissues&#44; including in the joints <a class="elsevierStyleCrossRef" href="#bib25">25</a>&#46; TNC has an important role in modulating the actions of TGF&#946; <a class="elsevierStyleCrossRef" href="#bib26">26</a> and is also regulated by TGF&#946; <a class="elsevierStyleCrossRef" href="#bib27">27</a>&#46; TNXB seems to regulate collagen synthesis or deposition <a class="elsevierStyleCrossRef" href="#bib28">28</a>&#46; A recent study showed that TNX also regulates TGF&#946; bioavailability and modulates cell plasticity <a class="elsevierStyleCrossRef" href="#bib29">29</a>&#46;</p><p id="para90" class="elsevierStylePara elsevierViewall">In the present study&#44; we quantified the mRNA expression of the <span class="elsevierStyleItalic">TGF&#946;1&#44; TGF&#946;R1&#44; LOX</span>&#44; <span class="elsevierStyleItalic">PLOD1&#44; PLOD2&#44; COMP&#44; FN1&#44; TNC</span> and <span class="elsevierStyleItalic">TNXB</span> genes in glenohumeral synovium&#47;capsule samples collected from patients with adhesive capsulitis and from controls&#46; We also evaluated how these mRNA levels are associated with clinical features&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">MATERIALS AND METHODS</span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">Patients</span><p id="para100" class="elsevierStylePara elsevierViewall">The current study used a case-control study design &#40;level 3 evidence&#41;&#46; All patients and controls were treated at the Hospital S&#227;o Paulo of the Universidade Federal de S&#227;o Paulo&#46; Each patient agreed to participate by signing a written consent form before data and sample collection&#46; This study was approved by the ethics committee of the Universidade Federal de S&#227;o Paulo &#40;approval number&#58; CEP 1918&#47;11&#41;&#46;</p><p id="para110" class="elsevierStylePara elsevierViewall">The case group was composed of 9 patients with idiopathic adhesive capsulitis of the shoulder in freezing or frozen stages who were diagnosed by clinical evaluation&#46; During the clinical evaluations&#44; the patients presented with pain&#44; loss of motion and severe limitations during daily activities&#59; no history of trauma or previous shoulder pathologies&#59; and functional restriction of both active and passive shoulder motion&#46; Magnetic resonance imaging &#40;MRI&#41; was used to exclude secondary stiff shoulder&#46; The patients underwent arthroscopic shoulder capsular release after a concerted effort was made to treat them with conservative management for at least 5 complete months&#46; In all cases&#44; the physiotherapy had failed&#46; Additionally&#44;patients meeting the following exclusion criteria were omitted&#58; generalized arthritis&#59; previous compromise of the shoulder&#44; such as major trauma&#44; fracture&#44; rotator cuff tear&#44; calcifying tendinitis&#44; or shoulder instability&#59; and superior labral anterior and posterior &#40;SLAP&#41; lesions&#46; Additionally&#44; patients who did not agree with the informed consent terms were excluded&#46; All enrolled patients underwent an arthroscopic procedure&#46;</p><p id="para120" class="elsevierStylePara elsevierViewall">The control group consisted of 8 physically active subjects who underwent arthroscopically assisted treatment for acute acromioclavicular dislocation&#46; None of the controls presented with a history of adhesive capsulitis&#46; Moreover&#44; radiological indication of glenohumeral capsule alteration was detected&#46; A standard complete joint evaluation by arthroscopy confirmed that the controls did not present any other concomitant pathology in the shoulder&#46;</p><p id="para130" class="elsevierStylePara elsevierViewall">All patients answered a preoperative questionnaire concerning gender&#44; age at surgery&#44; age of pain onset&#44; duration of symptoms&#44; bilaterality&#44; suprascapular nerve block&#44; physical activity&#44; type of work and smoking habits &#40;<a class="elsevierStyleCrossRef" href="#t1-cln_71p325">Table 1</a>&#41;&#46;</p><elsevierMultimedia ident="t1-cln_71p325"></elsevierMultimedia></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">Tissue samples</span><p id="para140" class="elsevierStylePara elsevierViewall">Tissue samples of approximately 2 mm<span class="elsevierStyleSup">3</span> were obtained from the anterior-inferior portion of the glenohumeral capsule during the arthroscopic procedure&#46; To reduce sampling variation&#44; only two of the authors &#40;CC and BE&#41; were responsible for collecting the tissue samples&#46; The samples were collected as previously described <a class="elsevierStyleCrossRefs" href="#bib30">30-32</a>&#46; As the synovium is adhered to the capsule&#44; it cannot be separated from the capsule using arthroscopic instruments&#46;</p><p id="para150" class="elsevierStylePara elsevierViewall">To provide immediate stabilization of RNA&#44; all synovium&#47;capsule specimens were instantly preserved in Allprotect Tissue Reagent&#174; &#40;Qiagen&#44; Germany&#41; and then stored at -20 &#176;C&#46;</p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">RNA extraction</span><p id="para160" class="elsevierStylePara elsevierViewall">An AllPrep DNA&#47;RNA&#47;miRNA Universal Kit &#40;Qiagen&#44; Germany&#41; was used to purify total RNA from the synovium&#47;capsule specimens&#46; Tissue Lyser LT equipment &#40;Qiagen&#44; USA&#41; was used to mechanically lyse the tissue samples&#46; A NanoDrop ND-1000 spectrophotometer &#40;Thermo Scientific&#44; USA&#41; was used to determine RNA concentration and quality&#46; RNA integrity was verified by 1&#37; agarose gel electrophoresis&#46; The RNA samples were stored at -80 &#176;C&#46;</p></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">mRNA expression analysis</span><p id="para170" class="elsevierStylePara elsevierViewall">Reverse transcription-quantitative polymerase chain reaction &#40;RT-qPCR&#41; was used to evaluate mRNA expression&#46; First&#44; a High-Capacity cDNA Archive kit &#40;Life Technologies&#44; USA&#41; was used for cDNA synthesis&#46; Then&#44; RT-qPCR was performed as previously described using a ViiA 7 Real-Time PCR System &#40;Life Technologies&#44; USA&#41; <a class="elsevierStyleCrossRef" href="#bib30">30</a>&#46; To exclude technical variations&#44; target and reference genes &#40;<a class="elsevierStyleCrossRef" href="#t2-cln_71p325">Table 2</a>&#41; were analyzed on the same TaqMan Low-Density Array &#40;TLDA&#41; cards &#40;Life Technologies&#44; USA&#41;&#46; All qPCR assays were performed in triplicate&#46; The <span class="elsevierStyleItalic">B2M</span> and <span class="elsevierStyleItalic">HPRT1</span> genes were used as reference genes to normalize sample input amount&#46; These genes were chosen based on a previous study of suitable internal controls for the evaluation of mRNA expression in shoulder capsule samples <a class="elsevierStyleCrossRef" href="#bib33">33</a>&#46;</p><elsevierMultimedia ident="t2-cln_71p325"></elsevierMultimedia><p id="para180" class="elsevierStylePara elsevierViewall">The relative cycle threshold method &#40;Crt method&#41; was used to quantify mRNA expression&#46; In this method&#44; the lower the cycle threshold value &#40;Crt&#41; value&#44; the greater the number of initial target copies in the sample&#46; Thus&#44; low Crt values indicate high gene expression&#46; The expression of the target genes was determined using the following equation&#58; &#916;Crt&#61;target gene Crt &#8211; the mean of the reference genes Crt&#46;</p></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">Statistical analysis</span><p id="para190" class="elsevierStylePara elsevierViewall">All &#916;Crt values are shown as the median with the interquartile range &#40;IQR&#41;&#46;</p><p id="para200" class="elsevierStylePara elsevierViewall">The gender and age distributions between the patients with adhesive capsulitis and the controls were compared using the Chi-square test and the Mann-Whitney test&#44; respectively&#46; The Mann-Whitney test was also applied to compare mRNA levels between the cases and the controls&#44; as well as to investigate the possible associations between mRNA expression and preoperative clinical variables&#44; such as gender&#44; practice of sports involving the upper limbs&#44; type of job &#40;manual <span class="elsevierStyleItalic">versus</span> non-manual job&#41; and smoking habits&#46; Spearman&#39;s correlation was used to assess possible correlations between mRNA levels and duration of symptoms or age at surgery&#58; a value below 0&#46;40 was considered a weak correlation&#44; a value between 0&#46;40 and 0&#46;59 was considered a moderate correlation&#44; a value between 0&#46;6 and 0&#46;79 was considered a strong correlation and a value &#8805;0&#46;80 was considered a very strong correlation&#46; For all analyses&#44; a <span class="elsevierStyleItalic">p</span>-value&#60;0&#46;05 was considered statistically significant&#46; Statistical analyses were performed using PASW &#40;SPSS&#41; software&#44; version 18 &#40;SPSS Inc&#46;&#44; Chicago&#44; USA&#41;&#46;</p></span></span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">RESULTS</span><span id="cesec90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">Differences between cases and controls</span><p id="para210" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#t1-cln_71p325">Table 1</a> presents the clinical variables of the study participants&#46; In the control group&#44; 1 &#40;12&#46;5&#37;&#41; individual was female and 7 &#40;87&#46;5&#37;&#41; were males&#46; The median age at the time of surgery was 31&#46;44 years &#40;IQR&#61;13&#46;5&#41;&#46; The gender distribution did not differ between the study groups &#40;<span class="elsevierStyleItalic">p</span>&#61;0&#46;05&#41;&#46; However&#44; the controls were significantly younger than the patients with adhesive capsulitis &#40;<span class="elsevierStyleItalic">p</span>&#61;0&#46;012&#44; Mann-Whitney test&#41;&#46;</p><p id="para220" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#t3-cln_71p325">Table 3</a> shows the median and IQR values for the expression levels of the studied genes in the samples from the patients and the controls&#46; The patients with adhesive capsulitis had higher levels of <span class="elsevierStyleItalic">TNC</span> &#40;<span class="elsevierStyleItalic">p</span>&#61;0&#46;005&#59; <a class="elsevierStyleCrossRef" href="#fig1-cln_71p325">Figure 1A</a>&#41; and <span class="elsevierStyleItalic">FN1</span> &#40;<span class="elsevierStyleItalic">p</span>&#61;0&#46;043&#59; <a class="elsevierStyleCrossRef" href="#fig1-cln_71p325">Figure 1B</a>&#41; expression compared to the controls&#46; No other significant differences were observed between the patients and the controls &#40;<span class="elsevierStyleItalic">p</span>&#62;0&#46;05&#41;&#46;</p><elsevierMultimedia ident="t3-cln_71p325"></elsevierMultimedia><elsevierMultimedia ident="fig1-cln_71p325"></elsevierMultimedia></span><span id="cesec100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">Associations between the clinical characteristics of adhesive capsulitis and mRNA expression</span><p id="para230" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#fig2-cln_71p325">Figure 2</a> shows the correlations between the duration of adhesive capsulitis symptoms and the expression levels of the studied genes&#46; In the tissue samples&#44; the expression of <span class="elsevierStyleItalic">TGF&#946;R1</span> mRNA was significantly and directly correlated with the duration of symptoms &#40;&#961;&#61;-0&#46;731&#44; <span class="elsevierStyleItalic">p</span>&#61;0&#46;025&#59; <a class="elsevierStyleCrossRef" href="#fig2-cln_71p325">Figure 2B</a>&#41;&#46;</p><elsevierMultimedia ident="fig2-cln_71p325"></elsevierMultimedia><p id="para240" class="elsevierStylePara elsevierViewall">No correlation was found between the age of the patients at the time of surgery and the age at symptom onset &#40;<span class="elsevierStyleItalic">p</span>&#62;0&#46;05&#41;&#46; Additionally&#44; no association was found between the mRNA levels of the studied genes and any of the clinical features assessed in the patients with adhesive capsulitis &#40;<span class="elsevierStyleItalic">p</span>&#62;0&#46;05&#41;&#46;</p></span></span><span id="cesec110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle150">DISCUSSION</span><p id="para250" class="elsevierStylePara elsevierViewall">Although adhesive capsulitis is considered a self-limited disease&#44; some patients show little to no improvement&#44; maintain a limited range of motion and continue to experience shoulder pain&#46; Non-operative treatment is the initial approach used for adhesive capsulitis&#46; However&#44; operative treatment &#40;such as arthroscopic capsular release&#41; may be considered when patients remain in pain and do not regain satisfactory range of motion after prolonged nonoperative treatment <a class="elsevierStyleCrossRef" href="#bib34">34</a>&#44;<a class="elsevierStyleCrossRef" href="#bib35">35</a>&#46;</p><p id="para260" class="elsevierStylePara elsevierViewall">In this study&#44; we found higher levels of <span class="elsevierStyleItalic">TNC</span> and <span class="elsevierStyleItalic">FN1</span> expression in glenohumeral synovium&#47;capsule samples collected from patients with adhesive capsulitis compared to those collected from controls&#46; TNC immunoreactivity was previously reported in other shoulder diseases&#44; including in rotator cuff tendon tears and in the subacromial bursa of patients with impingement syndrome <a class="elsevierStyleCrossRef" href="#bib36">36</a>&#44;<a class="elsevierStyleCrossRef" href="#bib37">37</a>&#46; In addition&#44; we have previously found that both <span class="elsevierStyleItalic">TNC</span> and <span class="elsevierStyleItalic">FN1</span> mRNA levels were upregulated in the glenohumeral capsules of patients with traumatic anterior shoulder instability &#40;unpublished data&#41;&#46; TNC is a large hexameric ECM glycoprotein that has roles in cell adhesion&#44; fibroblast migration and other processes related to tissue remodeling and wound healing <a class="elsevierStyleCrossRef" href="#bib38">38</a>&#44;<a class="elsevierStyleCrossRef" href="#bib39">39</a>&#46; TNC is specifically expressed following tissue damage&#44; being upregulated within 24 h of injury <a class="elsevierStyleCrossRef" href="#bib38">38</a>&#46; It is activated after local injury and down-regulated after tissue repair or scarring is completed <a class="elsevierStyleCrossRef" href="#bib40">40</a>&#46; Persistent expression of TNC is associated with several fibrotic diseases and with chronic non-healing wounds <a class="elsevierStyleCrossRef" href="#bib38">38</a>&#46;</p><p id="para270" class="elsevierStylePara elsevierViewall">Therefore&#44; we hypothesize that increased TNC expression may be a marker of capsule injury and the genes involved may participate in inflammatory and fibrotic processes in the glenohumeral capsule&#46;</p><p id="para280" class="elsevierStylePara elsevierViewall">FN is essential for collagen fibril assembly <a class="elsevierStyleCrossRef" href="#bib41">41</a>&#46; During the early phase of wound healing&#44; FN is deposited at sites of injury and can induce inflammation&#59; increase ECM deposition&#44; including of FN and collagen&#59; and activate fibroblasts&#46; These pathways can create a vicious cycle that eventually induces keloid formation or fibrosis <a class="elsevierStyleCrossRef" href="#bib42">42</a>&#46; Additionally&#44; FN has been previously associated with Dupuytren&#39;s contracture <a class="elsevierStyleCrossRef" href="#bib24">24</a>&#46; In this disease&#44; FN can be found in its oncofetal form <a class="elsevierStyleCrossRef" href="#bib43">43</a>&#44;<a class="elsevierStyleCrossRef" href="#bib44">44</a>&#46; Additionally&#44; upregulation of FN1 has been associated with fibrosis in inflammatory orbital diseases <a class="elsevierStyleCrossRef" href="#bib45">45</a>&#44; hepatic fibrosis <a class="elsevierStyleCrossRef" href="#bib46">46</a>&#44; idiopathic pulmonary fibrosis <a class="elsevierStyleCrossRef" href="#bib47">47</a>&#44;<a class="elsevierStyleCrossRef" href="#bib48">48</a> and liver fibrosis <a class="elsevierStyleCrossRef" href="#bib49">49</a>&#46; These relationships indicate that this molecule may also be involved in the pathogenesis of other fibrosing diseases&#46; Interestingly&#44; Altrock et al&#46; showed that blocking FN deposition using an FN assembly inhibitor &#40;pUR4&#41; resulted in decreased collagen accumulation and improved liver function during liver fibrogenesis <a class="elsevierStyleCrossRef" href="#bib50">50</a>&#46; Although only a slight increase in FN1 expression was detected in the glenohumeral capsules of the patients with adhesive capsulitis in the current study&#44; our results suggest that FN1 may play a role in the fibrotic process&#46; Further investigation is still necessary to understand the dynamic transcriptional regulation of FN1 that occurs within the shoulder capsule&#46;</p><p id="para290" class="elsevierStylePara elsevierViewall">We also observed that the expression of <span class="elsevierStyleItalic">TGF&#946;R1</span> mRNA in the capsule was directly correlated with symptom duration in the patients with adhesive capsulitis&#46; To the best of our knowledge&#44; only one previous study has evaluated the role of the TGF&#946; receptor in adhesive capsulitis <a class="elsevierStyleCrossRef" href="#bib5">5</a>&#46; Rodeo et al&#46; analyzed both <span class="elsevierStyleItalic">TGF&#946;</span> and its receptor in capsule and synovium samples collected from patients with adhesive capsulitis and in those collected from controls <a class="elsevierStyleCrossRef" href="#bib5">5</a>&#46; They performed a semi-quantitative analysis by comparing the frequency of positive staining between the groups&#46; The authors described that the synovial and capsular cells of patients with adhesive capsulitis and synovitis showed clear TGF&#946; and TGF&#946;R staining&#44; whereas no or minimal staining was observed in the normal tissue specimens&#46; The blood vessels of the affected tissues also presented staining for both proteins&#46; Moreover&#44; there was a higher frequency of positive TGF&#946; and TGF&#946;R staining in the synovial cells of the patients with adhesive capsulitis&#46; In addition&#44; there was a greater frequency of positive TGF&#946; staining in the ECMs of patients with adhesive capsulitis compared to the controls&#44; particularly in the capsule tissue&#46;</p><p id="para300" class="elsevierStylePara elsevierViewall">In the present study&#44; we found no differences in the expression of <span class="elsevierStyleItalic">TGF&#946;1</span> and <span class="elsevierStyleItalic">TGF&#946;R1</span> mRNA between the cases and the controls&#46; Because the synovium is adhered to the capsule and cannot be separated from the capsule using arthroscopic instruments&#44; our investigation did not discriminate between gene expression in synovial and capsular tissues&#46; However&#44; molecular alterations in both tissues are important in adhesive capsulitis <a class="elsevierStyleCrossRef" href="#bib51">51</a>&#46; In addition&#44; our study is the first to use a quantitative approach to evaluate the role of <span class="elsevierStyleItalic">TGF&#946;R1</span> in adhesive capsulitis&#46; Our results suggest that <span class="elsevierStyleItalic">TGF&#946;R1</span> may have a role in adhesive capsulitis&#44; especially in the long-term disease&#46;</p><p id="para310" class="elsevierStylePara elsevierViewall">To the best of our knowledge&#44; this study is the first to quantify <span class="elsevierStyleItalic">TGF&#946;1</span>&#44; <span class="elsevierStyleItalic">TGF&#946;R1&#44; LOX&#44; PLOD1</span>&#44; <span class="elsevierStyleItalic">PLOD2&#44; COMP&#44; FN1&#44; TNC</span> and <span class="elsevierStyleItalic">TNXB</span> mRNA expression in the shoulder capsules of patients with adhesive capsulitis&#46; However&#44; this study has some limitations&#46; First&#44; few patients with adhesive capsulitis are surgically treated&#59; as such&#44; there is a limited number of tissue samples available for studies of gene expression <a class="elsevierStyleCrossRef" href="#bib5">5</a>&#44;<a class="elsevierStyleCrossRef" href="#bib35">35</a>&#44;<a class="elsevierStyleCrossRefs" href="#bib52">52-59</a>&#46; Therefore&#44; some of our statistical analyses had reduced power to detect significant differences between the studied groups and false-negative results may have occurred&#46; Second&#44; we included patients who failed in conservative treatment in different phases of frozen shoulder&#44; some in freezing and others in frozen stages&#46; This heterogeneity may have also contributed to false negatives&#46; Third&#44; molecular alterations may occur in other capsule regions and may have a different etiological role in capsular injury <a class="elsevierStyleCrossRefs" href="#bib30">30-32</a>&#46; We evaluated the AI region because this portion of the capsule presented macroscopic injuries &#40;i&#46;e&#46;&#44; a high level of inflammation&#41; during arthroscopic examination of the studied patients&#46; Although we did not detect a correlation between age and gene expression in the tissue samples collected from the patients with adhesive capsulitis&#44; it is important to highlight that the age distribution between the patients and the controls was different&#46; Thus&#44; we cannot exclude that age might have influenced our findings&#46; Finally&#44; additional analysis of the protein products of the studied genes may be interesting because protein function is also affected by post-transcriptional and post-translational regulation&#46;</p><p id="para320" class="elsevierStylePara elsevierViewall">Elevated expression of <span class="elsevierStyleItalic">TNC</span> and <span class="elsevierStyleItalic">FN1</span> mRNA may be a marker of capsule injury and may be involved in capsule inflammation and fibrosis&#46; Upregulation of <span class="elsevierStyleItalic">TGF&#946;R1</span> seems to be related to symptom duration in adhesive capsulitis&#59; therefore&#44; TGF&#946; signaling may play a role in this condition&#46;</p></span><span id="cesec120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle160">AUTHOR CONTRIBUTIONS</span><p id="para330" class="elsevierStylePara elsevierViewall">Cohen C&#44; Leal MF&#44; Smith MC&#44; Ejnisman B and Faloppa F conceived and designed the experiments&#46; Cohen C&#44; Belangero PS&#44; Figueiredo EA&#44; Andreoli CV&#44; Pochini AC and Ejnisman B were involved in data collection&#46; Cohen C&#44; Belangero PS&#44; Figueiredo EA&#44; Figueiredo EA&#44; Pochini AC and Ejnisman B were responsible for sample collection&#46; Leal MF was involved in the genetic analysis&#46; Cohen C&#44; Leal MF&#44; Belangero PS and Figueiredo EA performed the literature search&#46; Leal MF and Smith MC were involved in data and statistical analyses&#46; Cohen C and Leal MF wrote the first draft of the manuscript&#46; All authors listed have contributed to all subsequent drafts and all have approved the final manuscript&#46;</p></span></span>"
    "textoCompletoSecciones" => array:1 [
      "secciones" => array:8 [
        0 => array:2 [
          "identificador" => "xpalclavsec1580457"
          "titulo" => "KEYWORDS"
        ]
        1 => array:2 [
          "identificador" => "cesec10"
          "titulo" => "INTRODUCTION"
        ]
        2 => array:3 [
          "identificador" => "cesec20"
          "titulo" => "MATERIALS AND METHODS"
          "secciones" => array:5 [
            0 => array:2 [
              "identificador" => "cesec30"
              "titulo" => "Patients"
            ]
            1 => array:2 [
              "identificador" => "cesec40"
              "titulo" => "Tissue samples"
            ]
            2 => array:2 [
              "identificador" => "cesec50"
              "titulo" => "RNA extraction"
            ]
            3 => array:2 [
              "identificador" => "cesec60"
              "titulo" => "mRNA expression analysis"
            ]
            4 => array:2 [
              "identificador" => "cesec70"
              "titulo" => "Statistical analysis"
            ]
          ]
        ]
        3 => array:3 [
          "identificador" => "cesec80"
          "titulo" => "RESULTS"
          "secciones" => array:2 [
            0 => array:2 [
              "identificador" => "cesec90"
              "titulo" => "Differences between cases and controls"
            ]
            1 => array:2 [
              "identificador" => "cesec100"
              "titulo" => "Associations between the clinical characteristics of adhesive capsulitis and mRNA expression"
            ]
          ]
        ]
        4 => array:2 [
          "identificador" => "cesec110"
          "titulo" => "DISCUSSION"
        ]
        5 => array:2 [
          "identificador" => "cesec120"
          "titulo" => "AUTHOR CONTRIBUTIONS"
        ]
        6 => array:2 [
          "identificador" => "xack638307"
          "titulo" => "ACKNOWLEDGMENTS"
        ]
        7 => array:1 [
          "titulo" => "REFERENCES"
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-12-15"
    "fechaAceptado" => "2016-03-21"
    "PalabrasClave" => array:1 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "KEYWORDS"
          "identificador" => "xpalclavsec1580457"
          "palabras" => array:5 [
            0 => "Adhesive Capsulitis"
            1 => "Glenohumeral Capsule"
            2 => "Gene Expression"
            3 => "Extracellular Matrix"
            4 => "<span class="elsevierStyleItalic">TGF&#946;1</span> Signaling"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:1 [
      "en" => array:2 [
        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVES&#58;</span><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">We evaluated mRNA expression levels of genes that encode TGF-&#946;1&#59; the TGF-&#946;1 receptor&#59; the collagen-modifying enzymes LOX&#44; PLOD1&#44; and PLOD2&#59; and the extracellular matrix proteins COMP&#44; FN1&#44; TNC and TNXB in synovial&#47;capsule specimens from patients with idiopathic adhesive capsulitis&#46; Possible associations between the measured mRNA levels and clinical parameters were also investigated&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHODS&#58;</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">We obtained glenohumeral joint synovium&#47;capsule specimens from 9 patients with idiopathic adhesive capsulitis who had not shown improvement in symptoms after 5 months of physiotherapy&#46; Adhesive capsulitis was confirmed in all patients by magnetic resonance imaging&#46; We also obtained specimens from 8 control patients who had underwent surgery for acute acromioclavicular joint dislocation and who had radiological indication of glenohumeral capsule alteration based on arthroscopic evaluation&#46; mRNA expression in the synovium&#47;capsule specimens was analyzed by quantitative reverse transcription PCR&#46; The <span class="elsevierStyleItalic">B2M</span> and <span class="elsevierStyleItalic">HPRT1</span> genes were used as references to normalize target gene expression in the shoulder tissue samples&#46;</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS&#58;</span><p id="spara90" class="elsevierStyleSimplePara elsevierViewall">The synovium&#47;capsule samples from the patients with adhesive capsulitis had significantly higher <span class="elsevierStyleItalic">TNC</span> and <span class="elsevierStyleItalic">FN1</span> expression than those from the controls&#46; Additionally&#44; symptom duration directly correlated with expression of <span class="elsevierStyleItalic">TGF&#946;1 receptor I</span>&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSION&#58;</span><p id="spara100" class="elsevierStyleSimplePara elsevierViewall">Elevated levels of <span class="elsevierStyleItalic">TNC</span> and <span class="elsevierStyleItalic">FN1</span> expression may be a marker of capsule injury&#46; Upregulation of <span class="elsevierStyleItalic">TGF&#946;1 receptor I</span> seems to be dependent on symptom duration&#59; therefore&#44; <span class="elsevierStyleItalic">TGF&#946;</span> signaling may be involved in adhesive capsulitis&#46; As such&#44; <span class="elsevierStyleItalic">TNC&#44; FN1</span> and <span class="elsevierStyleItalic">TGF&#946;1 receptor I</span> may also play roles in adhesive capsulitis by contributing to capsule inflammation and fibrosis&#46;</p></span>"
        "secciones" => array:4 [
          0 => array:2 [
            "identificador" => "ceabs10"
            "titulo" => "OBJECTIVES&#58;"
          ]
          1 => array:2 [
            "identificador" => "ceabs20"
            "titulo" => "METHODS&#58;"
          ]
          2 => array:2 [
            "identificador" => "ceabs30"
            "titulo" => "RESULTS&#58;"
          ]
          3 => array:2 [
            "identificador" => "ceabs40"
            "titulo" => "CONCLUSION&#58;"
          ]
        ]
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara" id="cenpara40">No potential conflict of interest was reported&#46;</p>"
      ]
    ]
    "multimedia" => array:5 [
      0 => array:7 [
        "identificador" => "fig1-cln_71p325"
        "etiqueta" => "Figure 1"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "cln-71-06-325-g001.jpeg"
            "Alto" => 264
            "Ancho" => 800
            "Tamanyo" => 28265
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">TNC</span> &#40;A&#41; and <span class="elsevierStyleItalic">FN1</span> &#40;B&#41; expression levels in capsule samples collected from patients with adhesive capsulitis and controls&#46; A lower delta cycle threshold value &#40;&#916;Crt&#41; indicates higher gene expression&#46; Box plots show the median and interquartile range&#46; &#42;A significant difference between groups by Mann-Whitney test &#40;<span class="elsevierStyleItalic">p</span> &#60;0&#46;05&#41;&#46;</p>"
        ]
      ]
      1 => array:7 [
        "identificador" => "fig2-cln_71p325"
        "etiqueta" => "Figure 2"
        "tipo" => "MULTIMEDIAFIGURA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "figura" => array:1 [
          0 => array:4 [
            "imagen" => "cln-71-06-325-g002.jpeg"
            "Alto" => 617
            "Ancho" => 800
            "Tamanyo" => 52674
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Correlation between gene expression and duration of adhesive capsulitis &#40;months&#41;&#46; A&#41; <span class="elsevierStyleItalic">TGF&#946;1</span>&#59; B&#41; <span class="elsevierStyleItalic">TGF&#946;R1</span>&#59; C&#41; <span class="elsevierStyleItalic">LOX</span>&#59; D&#41; <span class="elsevierStyleItalic">PLOD1</span>&#59; E&#41; <span class="elsevierStyleItalic">PLOD2</span>&#59; F&#41; <span class="elsevierStyleItalic">COMP</span>&#59; G&#41; <span class="elsevierStyleItalic">FN1</span>&#59; H&#41; <span class="elsevierStyleItalic">TNC</span>&#59; and I&#41; <span class="elsevierStyleItalic">TNXB&#46;</span> &#961;&#58; Spearman correlation coefficient &#40;&#8220;rho&#8221;&#41;&#46; <span class="elsevierStyleItalic">&#42;</span>Significant correlation &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;05&#41;&#46; A lower delta cycle threshold value &#40;&#916;Crt&#41; indicates higher gene expression&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "t1-cln_71p325"
        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">N&#58; number of patients&#59; IQR&#58; interquartile range&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Distribution&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age at surgery&#44; years &#91;median &#40;IQR&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">51&#46;7 &#40;16&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Age at symptom onset&#44; years &#91;median &#40;IQR&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">50&#46;4 &#40;14&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Gender &#91;N&#40;&#37;&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Male&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Female&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Duration of condition&#44; months &#91;median &#40;IQR&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">10&#46;67 &#40;10&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Bilaterality &#91;N&#40;&#37;&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Practice of sports involving the upper limbs &#91;N &#40;&#37;&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>No&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Yes&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Type of job &#91;N&#40;&#37;&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Non-manual&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">6 &#40;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Manual&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3 &#40;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Smoking habits &#91;N&#40;&#37;&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Non-smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">8 &#40;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span><span class="elsevierStyleHsp" style=""></span>Smoker&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1 &#40;11&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Distribution of clinical variables for patients with adhesive capsulitis&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "t2-cln_71p325"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Gene symbol&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Name&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Assay<a class="elsevierStyleCrossRef" href="#tfn2-cln_71p325">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">TGF&#946;1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Transforming growth factor&#44; beta 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hs00998133&#95;m1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">TGF&#946;R1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Transforming growth factor&#44; beta receptor 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hs00610320&#95;m1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">LOX</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lysyl oxidase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hs00942480&#95;m1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">PLOD1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lysyl hydroxylases 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hs00609368&#95;m1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">PLOD2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Lysyl hydroxylases 2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hs01118190&#95;m1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">COMP</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Cartilage oligomeric matrix protein&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hs00164359&#95;m1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">FN1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Fibronectin 1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hs00365052&#95;m1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">TNC</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tenascin C&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hs01115665&#95;m1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">TNXB</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Tenascin XB&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hs00372889&#95;g1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">B2M</span><a class="elsevierStyleCrossRef" href="#tfn3-cln_71p325">&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Beta-2-microglobulin&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hs00984230&#95;m1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">HPRT1</span><a class="elsevierStyleCrossRef" href="#tfn3-cln_71p325">&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hypoxanthine phosphoribosyl-transferase&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">Hs02800695&#95;m1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tfn2-cln_71p325"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">TaqMan probes were purchased as assay-on-demand products for gene expression &#40;Life Technologies&#44; USA&#41;&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "tfn3-cln_71p325"
              "etiqueta" => "&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara20">Reference genes for target gene expression normalization&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">Summary of reference gene and target gene assays&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "t3-cln_71p325"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Gene&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Cases &#91;&#916;Crt&#59; Median &#40;IQR&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col">Controls &#91;&#916;Crt&#59; Median &#40;IQR&#41;&#93;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t" scope="col"><span class="elsevierStyleItalic">p</span>-value&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">TGF&#946;1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;99 &#40;0&#46;62&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;57 &#40;0&#46;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;149&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">TGF&#946;R1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;77 &#40;1&#46;04&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;47 &#40;0&#46;73&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;923&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">LOX</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;16 &#40;2&#46;27&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;37 &#40;1&#46;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;700&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">PLOD1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;95 &#40;0&#46;62&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;07 &#40;0&#46;48&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;336&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">PLOD2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">2&#46;39 &#40;0&#46;82&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">3&#46;11 &#40;1&#46;08&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;068&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">COMP</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;39 &#40;3&#46;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-0&#46;01 &#40;2&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;336&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">FN1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-5&#46;65 &#40;1&#46;53&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-4&#46;85 &#40;0&#46;79&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;043<a class="elsevierStyleCrossRef" href="#tfn4-cln_71p325">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">TNC</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-1&#46;48 &#40;1&#46;72&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;36 &#40;1&#46;31&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;005<a class="elsevierStyleCrossRef" href="#tfn4-cln_71p325">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleItalic">TNXB</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-2&#46;55 &#40;1&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">-2&#46;79 &#40;1&#46;03&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;290&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:1 [
            0 => array:3 [
              "identificador" => "tfn4-cln_71p325"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara30">Significant difference between groups by Mann-Whitney test &#40;<span class="elsevierStyleItalic">p&#60;</span>0&#46;05&#41;&#46; IQR&#58; interquartile range&#46; A lower delta cycle threshold value &#40;&#916;Crt&#41; indicates higher gene expression&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara60" class="elsevierStyleSimplePara elsevierViewall">Gene expression patterns in the glenohumeral capsules of patients with adhesive capsulitis and in controls&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:59 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Diagnosis and management of adhesive capsulitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              RC Manske \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              D Prohaska \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1007/s12178-008-9031-6"
                      "Revista" => array:7 [
                        "tituloSerie" => "Curr Rev Musculoskelet Med"
                        "fecha" => "2008"
                        "volumen" => "1"
                        "numero" => "3-4"
                        "paginaInicial" => "180"
                        "paginaFinal" => "189"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19468904"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1007/s12178-008-9031-6"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1007&#47;s12178-008-9031-6"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary frozen shoulder&#58; brief review of pathology and imaging abnormalities"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              K Tamai \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              M Akutsu \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              Y Yano \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1007/s00776-013-0495-x"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Orthop Sci"
                        "fecha" => "2014"
                        "volumen" => "19"
                        "numero" => "1"
                        "paginaInicial" => "1"
                        "paginaFinal" => "5"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24306579"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1007/s00776-013-0495-x"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1007&#47;s00776-013-0495-x"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathology of frozen shoulder"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              GC Hand \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              NA Athanasou \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              T Matthews \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              AJ Carr \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1302/0301-620X.89B7.19097"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Bone Joint Surg Br"
                        "fecha" => "2007"
                        "volumen" => "89"
                        "numero" => "7"
                        "paginaInicial" => "928"
                        "paginaFinal" => "932"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17673588"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1302/0301-620X.89B7.19097"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1302&#47;0301-620X&#46;89B7&#46;19097"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The pathology of frozen shoulder&#46; A Dupuytren-like disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              TD Bunker \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              PP Anthony \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "J Bone Joint Surg Br"
                        "fecha" => "1995"
                        "volumen" => "77"
                        "numero" => "5"
                        "paginaInicial" => "677"
                        "paginaFinal" => "683"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7559688"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Immunolocalization of cytokines and their receptors in adhesive capsulitis of the shoulder"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              SA Rodeo \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              JA Hannafin \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              J Tom \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              RF Warren \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              TL Wickiewicz \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1002/jor.1100150316"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Orthop Res"
                        "fecha" => "1997"
                        "volumen" => "15"
                        "numero" => "3"
                        "paginaInicial" => "427"
                        "paginaFinal" => "436"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9246090"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1002/jor.1100150316"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1002&#47;jor&#46;1100150316"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cytokines and human fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              EC LeRoy \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              MI Trojanowska \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              EA Smith \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Eur Cytokine Netw"
                        "fecha" => "1990"
                        "volumen" => "1"
                        "numero" => "4"
                        "paginaInicial" => "215"
                        "paginaFinal" => "219"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1966552"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transforming growth factor-beta &#40;TGF-beta&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              DA Clark \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              R Coker \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/s1357-2725(97)00128-3"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Biochem Cell Biol"
                        "fecha" => "1998"
                        "volumen" => "30"
                        "numero" => "3"
                        "paginaInicial" => "293"
                        "paginaFinal" => "298"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9611771"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/s1357-2725(97)00128-3"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;S1357-2725&#40;97&#41;00128-3"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Mechanism of activation of the TGF-beta receptor"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              JL Wrana \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              L Attisano \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              R Wieser \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              F Ventura \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              J Massague \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1038/370341a0"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nature"
                        "fecha" => "1994"
                        "volumen" => "370"
                        "numero" => "6488"
                        "paginaInicial" => "341"
                        "paginaFinal" => "347"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8047140"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1038/370341a0"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1038&#47;370341a0"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TGFBR1 signaling and breast cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              L Moore-Smith \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              B Pasche \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1007/s10911-011-9216-2"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Mammary Gland Biol Neoplasia"
                        "fecha" => "2011"
                        "volumen" => "16"
                        "numero" => "2"
                        "paginaInicial" => "89"
                        "paginaFinal" => "95"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21461994"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1007/s10911-011-9216-2"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1007&#47;s10911-011-9216-2"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differences in cellular properties and responses to growth factors between human ACL and MCL cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              M Yoshida \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              K Fujii \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1007/s007760050106"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Orthop Sci"
                        "fecha" => "1999"
                        "volumen" => "4"
                        "numero" => "4"
                        "paginaInicial" => "293"
                        "paginaFinal" => "298"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10436277"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1007/s007760050106"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1007&#47;s007760050106"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Differential effects of bone morphogenetic protein-2 and transforming growth factor-beta1 on gene expression of collagen-modifying enzymes in human adipose tissue-derived mesenchymal stem cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              M Knippenberg \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              MN Helder \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              BZ Doulabi \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              RA Bank \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              PI Wuisman \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              J Klein-Nulend \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1089/ten.tea.2007.0184"
                      "Revista" => array:7 [
                        "tituloSerie" => "Tissue Eng Part A"
                        "fecha" => "2009"
                        "volumen" => "15"
                        "numero" => "8"
                        "paginaInicial" => "2213"
                        "paginaFinal" => "2225"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19231972"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1089/ten.tea.2007.0184"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1089&#47;ten&#46;tea&#46;2007&#46;0184"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "TGF-ss induces Lysyl hydroxylase 2b in human synovial osteoarthritic fibroblasts through ALK5 signaling"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              DF Remst \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              EN Blaney Davidson \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              EL Vitters \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              RA Bank \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              WB van den Berg \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              PM van der Kraan \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1007/s00441-013-1740-5"
                      "Revista" => array:7 [
                        "tituloSerie" => "Cell Tissue Res"
                        "fecha" => "2014"
                        "volumen" => "355"
                        "numero" => "1"
                        "paginaInicial" => "163"
                        "paginaFinal" => "171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24192939"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1007/s00441-013-1740-5"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1007&#47;s00441-013-1740-5"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Deregulation of the lysyl hydroxylase matrix cross-linking system in experimental and clinical bronchopulmonary dysplasia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              TJ Witsch \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              P Turowski \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              E Sakkas \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              G Niess \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              S Becker \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              S Herold \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1152/ajplung.00109.2013"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Physiol Lung Cell Mol Physiol"
                        "fecha" => "2014"
                        "volumen" => "306"
                        "numero" => "3"
                        "paginaInicial" => "L246"
                        "paginaFinal" => "L259"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24285264"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1152/ajplung.00109.2013"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1152&#47;ajplung&#46;00109&#46;2013"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lysyl oxidase&#58; properties&#44; regulation and multiple functions in biology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              LI Smith-Mungo \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              HM Kagan \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/s0945-053x(98)90012-9"
                      "Revista" => array:7 [
                        "tituloSerie" => "Matrix Biol"
                        "fecha" => "1998"
                        "volumen" => "16"
                        "numero" => "7"
                        "paginaInicial" => "387"
                        "paginaFinal" => "398"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9524359"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/s0945-053x(98)90012-9"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;S0945-053X&#40;98&#41;90012-9"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Lysyl oxidase&#58; properties&#44; specificity&#44; and biological roles inside and outside of the cell"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              HM Kagan \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              W Li \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1002/jcb.10413"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cell Biochem"
                        "fecha" => "2003"
                        "volumen" => "88"
                        "numero" => "4"
                        "paginaInicial" => "660"
                        "paginaFinal" => "672"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12577300"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1002/jcb.10413"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1002&#47;jcb&#46;10413"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expanding the lysyl hydroxylase toolbox&#58; new insights into the localization and activities of lysyl hydroxylase 3 &#40;LH3&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              R Myllyla \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              C Wang \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              J Heikkinen \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              A Juffer \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              O Lampela \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              M Risteli \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1002/jcp.21036"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cell Physiol"
                        "fecha" => "2007"
                        "volumen" => "212"
                        "numero" => "2"
                        "paginaInicial" => "323"
                        "paginaFinal" => "329"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17516569"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1002/jcp.21036"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1002&#47;jcp&#46;21036"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Quantitation of hydroxypyridinium crosslinks in collagen by high-performance liquid chromatography"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              DR Eyre \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              TJ Koob \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              KP Van Ness \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/0003-2697(84)90101-5"
                      "Revista" => array:7 [
                        "tituloSerie" => "Anal Biochem"
                        "fecha" => "1984"
                        "volumen" => "137"
                        "numero" => "2"
                        "paginaInicial" => "380"
                        "paginaFinal" => "388"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6731820"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/0003-2697(84)90101-5"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;0003-2697&#38;&#40;84&#41;90101-5"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              AJ van der Slot \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AM Zuurmond \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              AJ van den Bogaerdt \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              MM Ulrich \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              E Middelkoop \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              W Boers \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.matbio.2004.06.001"
                      "Revista" => array:7 [
                        "tituloSerie" => "Matrix Biol"
                        "fecha" => "2004"
                        "volumen" => "23"
                        "numero" => "4"
                        "paginaInicial" => "251"
                        "paginaFinal" => "257"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15296939"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.matbio.2004.06.001"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;matbio&#46;2004&#46;06&#46;001"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              K Rosenberg \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              H Olsson \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M Morgelin \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              D Heinegard \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.273.32.20397"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "1998"
                        "volumen" => "273"
                        "numero" => "32"
                        "paginaInicial" => "20397"
                        "paginaFinal" => "20403"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9685393"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1074/jbc.273.32.20397"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1074&#47;jbc&#46;273&#46;32&#46;20397"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enhanced activity of transforming growth factor beta1 &#40;TGF-beta1&#41; bound to cartilage oligomeric matrix protein"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              DR Haudenschild \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              E Hong \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JH Yik \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              B Chromy \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              M Morgelin \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              KD Snow \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.M111.234716"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "2011"
                        "volumen" => "286"
                        "numero" => "50"
                        "paginaInicial" => "43250"
                        "paginaFinal" => "43258"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21940632"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1074/jbc.M111.234716"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1074&#47;jbc&#46;M111&#46;234716"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cartilage oligomeric matrix protein is overexpressed by scleroderma dermal fibroblasts"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              G Farina \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              R Lemaire \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JH Korn \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              RL Widom \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.matbio.2006.01.007"
                      "Revista" => array:7 [
                        "tituloSerie" => "Matrix Biol"
                        "fecha" => "2006"
                        "volumen" => "25"
                        "numero" => "4"
                        "paginaInicial" => "213"
                        "paginaFinal" => "222"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16520029"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.matbio.2006.01.007"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;matbio&#46;2006&#46;01&#46;007"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Extracellular matrix&#58; from atomic resolution to ultrastructure"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              I Vakonakis \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              ID Campbell \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ceb.2007.09.005"
                      "Revista" => array:7 [
                        "tituloSerie" => "Curr Opin Cell Biol"
                        "fecha" => "2007"
                        "volumen" => "19"
                        "numero" => "5"
                        "paginaInicial" => "578"
                        "paginaFinal" => "583"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17942296"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.ceb.2007.09.005"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;ceb&#46;2007&#46;09&#46;005"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibronectin regulates latent transforming growth factor-beta &#40;TGF beta&#41; by controlling matrix assembly of latent TGF beta-binding protein-1"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              SL Dallas \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              P Sivakumar \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              CJ Jones \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              Q Chen \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              DM Peters \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              DF Mosher \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.M410762200"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "2005"
                        "volumen" => "280"
                        "numero" => "19"
                        "paginaInicial" => "18871"
                        "paginaFinal" => "18880"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15677465"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1074/jbc.M410762200"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1074&#47;jbc&#46;M410762200"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Dupuytren&#39;s contracture&#58; an update of biomolecular aspects and therapeutic perspectives"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              A Cordova \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              M Tripoli \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              B Corradino \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              P Napoli \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              F Moschella \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jhsb.2005.07.002"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Hand Surg Br"
                        "fecha" => "2005"
                        "volumen" => "30"
                        "numero" => "6"
                        "paginaInicial" => "557"
                        "paginaFinal" => "562"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16168532"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.jhsb.2005.07.002"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;jhsb&#46;2005&#46;07&#46;002"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Joint hypermobility syndromes&#58; the pathophysiologic role of tenascin-X gene defects"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              MC Zweers \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AJ Hakim \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              R Grahame \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              J Schalkwijk \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1002/art.20488"
                      "Revista" => array:7 [
                        "tituloSerie" => "Arthritis Rheum"
                        "fecha" => "2004"
                        "volumen" => "50"
                        "numero" => "9"
                        "paginaInicial" => "2742"
                        "paginaFinal" => "2749"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15457441"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1002/art.20488"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1002&#47;art&#46;20488"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tenascin-C deficiency attenuates TGF-ss-mediated fibrosis following murine lung injury"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              WA Carey \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              GD Taylor \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              WB Dean \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              JD Bristow \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1152/ajplung.00385.2009"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Physiol Lung Cell Mol Physiol"
                        "fecha" => "2010"
                        "volumen" => "299"
                        "numero" => "6"
                        "paginaInicial" => "L785"
                        "paginaFinal" => "L793"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20833777"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1152/ajplung.00385.2009"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1152&#47;ajplung&#46;00385&#46;2009"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            26 => array:3 [
              "identificador" => "bib27"
              "etiqueta" => "27"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tenascins and the importance of adhesion modulation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              R Chiquet-Ehrismann \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RP Tucker \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Cold Spring Harb Perspect Biol"
                        "fecha" => "2011"
                        "volumen" => "3"
                        "numero" => "5"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1101&#47;cshperspect&#46;a004960"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib28"
              "etiqueta" => "28"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tenascin-X deficiency mimics Ehlers-Danlos syndrome in mice through alteration of collagen deposition"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              JR Mao \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              G Taylor \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              WB Dean \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              DR Wagner \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              V Afzal \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              JC Lotz \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1038/ng850"
                      "Revista" => array:7 [
                        "tituloSerie" => "Nat Genet"
                        "fecha" => "2002"
                        "volumen" => "30"
                        "numero" => "4"
                        "paginaInicial" => "421"
                        "paginaFinal" => "425"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11925569"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1038/ng850"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1038&#47;ng850"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib29"
              "etiqueta" => "29"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tenascin-X&#58; beyond the architectural function"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              U Valcourt \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              LB Alcaraz \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JY Exposito \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              C Lethias \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              L Bartholin \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.4161/19336918.2014.994893"
                      "Revista" => array:7 [
                        "tituloSerie" => "Cell Adh Migr"
                        "fecha" => "2015"
                        "volumen" => "9"
                        "numero" => "1-2"
                        "paginaInicial" => "154"
                        "paginaFinal" => "165"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25793578"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.4161/19336918.2014.994893"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;4161&#47;19336918&#46;2014&#46;994893"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib30"
              "etiqueta" => "30"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression analysis of genes involved in collagen cross-linking and its regulation in traumatic anterior shoulder instability"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              PS Belangero \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              MF Leal \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Cohen \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              EA Figueiredo \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              MC Smith \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              CV Andreoli \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "J Orthop Res"
                        "fecha" => "2015"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1002&#47;jor&#46;22984"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib31"
              "etiqueta" => "31"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Profile of collagen gene expression in the glenohumeral capsule of patients with traumatic anterior instability of the shoulder"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              PS Belangero \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              MF Leal \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              A de Castro Pochini \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              CV Andreoli \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              B Ejnisman \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              M Cohen \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.rboe.2014.10.008"
                      "Revista" => array:7 [
                        "tituloSerie" => "Rev Bras Ortop"
                        "fecha" => "2014"
                        "volumen" => "49"
                        "numero" => "6"
                        "paginaInicial" => "642"
                        "paginaFinal" => "646"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26229875"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.rboe.2014.10.008"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;rbo&#46;2013&#46;10&#46;012"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib32"
              "etiqueta" => "32"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Gene expression analysis in patients with traumatic anterior shoulder instability suggests deregulation of collagen genes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              PS Belangero \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              MF Leal \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              EA Figueiredo \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              C Cohen \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              C Pochini Ade \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              MC Smith \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1002/jor.22680"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Orthop Res"
                        "fecha" => "2014"
                        "volumen" => "32"
                        "numero" => "10"
                        "paginaInicial" => "1311"
                        "paginaFinal" => "1316"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25042113"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1002/jor.22680"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1002&#47;jor&#46;22680"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            32 => array:3 [
              "identificador" => "bib33"
              "etiqueta" => "33"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Identification of suitable reference genes for gene expression studies of shoulder instability"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              MF Leal \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              PS Belangero \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Cohen \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              EA Figueiredo \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              LC Loyola \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              AC Pochini \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "PloS One"
                        "fecha" => "2014"
                        "volumen" => "9"
                        "numero" => "8"
                      ]
                    ]
                    1 => array:1 [
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1371&#47;journal&#46;pone&#46;0105002"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib34"
              "etiqueta" => "34"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Arthroscopic capsular release for the treatment of refractory postoperative or post-fracture shoulder stiffness"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              GB Holloway \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              T Schenk \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              GR Williams \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              ML Ramsey \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JP Iannotti \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Bone Joint Surg Am"
                        "fecha" => "2001"
                        "volumen" => "83-A"
                        "numero" => "11"
                        "paginaInicial" => "1682"
                        "paginaFinal" => "1687"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            34 => array:3 [
              "identificador" => "bib35"
              "etiqueta" => "35"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Coexistence of fibrotic and chondrogenic process in the capsule of idiopathic frozen shoulders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              Y Hagiwara \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Ando \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              Y Onoda \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              T Takemura \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              T Minowa \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              N Hanagata \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.joca.2011.12.008"
                      "Revista" => array:7 [
                        "tituloSerie" => "Osteoarthritis Cartilage"
                        "fecha" => "2012"
                        "volumen" => "20"
                        "numero" => "3"
                        "paginaInicial" => "241"
                        "paginaFinal" => "249"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22233812"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.joca.2011.12.008"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;joca&#46;2011&#46;12&#46;008"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib36"
              "etiqueta" => "36"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tenascin-C and human tendon degeneration"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => """
                              GP Riley \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              RL Harrall \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              TE Cawston \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              BL Hazleman \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              EJ Mackie \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Pathol"
                        "fecha" => "1996"
                        "volumen" => "149"
                        "numero" => "3"
                        "paginaInicial" => "933"
                        "paginaFinal" => "943"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8780397"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib37"
              "etiqueta" => "37"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Involvement of the subacromial bursa in impingement syndrome of the shoulder as judged by expression of tenascin-C and histopathology"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              P Hyvonen \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              J Melkko \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              VP Lehto \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              P Jalovaara \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1302/0301-620x.85b2.13124"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Bone Joint Surg Br"
                        "fecha" => "2003"
                        "volumen" => "85"
                        "numero" => "2"
                        "paginaInicial" => "299"
                        "paginaFinal" => "305"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12678373"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1302/0301-620x.85b2.13124"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1302&#47;0301-620X&#46;85B2&#46;13124"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib38"
              "etiqueta" => "38"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Regulation of fibroblast migration by tenascin-C"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              A Trebaul \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              EK Chan \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              KS Midwood \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1042/BST0350695"
                      "Revista" => array:7 [
                        "tituloSerie" => "Biochem Soc Trans"
                        "fecha" => "2007"
                        "volumen" => "35"
                        "numero" => "Pt 4"
                        "paginaInicial" => "695"
                        "paginaFinal" => "697"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17635125"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1042/BST0350695"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1042&#47;BST0350695"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            38 => array:3 [
              "identificador" => "bib39"
              "etiqueta" => "39"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Reparative capacity of airway epithelium impacts deposition and remodeling of extracellular matrix"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              JC Snyder \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              AC Zemke \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              BR Stripp \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1165/rcmb.2008-0334OC"
                      "Revista" => array:7 [
                        "tituloSerie" => "Am J Respir Cell Mol Biol"
                        "fecha" => "2009"
                        "volumen" => "40"
                        "numero" => "6"
                        "paginaInicial" => "633"
                        "paginaFinal" => "642"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18978301"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1165/rcmb.2008-0334OC"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1165&#47;rcmb&#46;2008-0334OC"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            39 => array:3 [
              "identificador" => "bib40"
              "etiqueta" => "40"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The role of tenascin-C in tissue injury and tumorigenesis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              KS Midwood \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              G Orend \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1007/s12079-009-0075-1"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cell Commun Signal"
                        "fecha" => "2009"
                        "volumen" => "3"
                        "numero" => "3-4"
                        "paginaInicial" => "287"
                        "paginaFinal" => "310"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19838819"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1007/s12079-009-0075-1"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1007&#47;s12079-009-0075-1"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            40 => array:3 [
              "identificador" => "bib41"
              "etiqueta" => "41"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Collagen fibrillogenesis&#58; fibronectin&#44; integrins&#44; and minor collagens as organizers and nucleators"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              KE Kadler \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              A Hill \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              EG Canty-Laird \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ceb.2008.06.008"
                      "Revista" => array:7 [
                        "tituloSerie" => "Curr Opin Cell Biol"
                        "fecha" => "2008"
                        "volumen" => "20"
                        "numero" => "5"
                        "paginaInicial" => "495"
                        "paginaFinal" => "501"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18640274"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.ceb.2008.06.008"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;ceb&#46;2008&#46;06&#46;008"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib42"
              "etiqueta" => "42"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "EDA Fibronectin in Keloids Create a Vicious Cycle of Fibrotic Tumor Formation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              RM Kelsh \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              PJ McKeown-Longo \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              RA Clark \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1038/jid.2015.155"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Invest Dermatol"
                        "fecha" => "2015"
                        "volumen" => "135"
                        "numero" => "7"
                        "paginaInicial" => "1714"
                        "paginaFinal" => "1718"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26066891"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1038/jid.2015.155"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1038&#47;jid&#46;2015&#46;155"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            42 => array:3 [
              "identificador" => "bib43"
              "etiqueta" => "43"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              RA Ignotz \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              J Massague \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "The Journal of biological chemistry"
                        "fecha" => "1986"
                        "volumen" => "261"
                        "numero" => "9"
                        "paginaInicial" => "4337"
                        "paginaFinal" => "4345"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3456347"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            43 => array:3 [
              "identificador" => "bib44"
              "etiqueta" => "44"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Wound healing-associated proteins Hsp47 and fibronectin are elevated in Dupuytren&#39;s contracture"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              JC Howard \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              VM Varallo \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              DC Ross \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              KJ Faber \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              JH Roth \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              S Seney \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jss.2004.01.013"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Surg Res"
                        "fecha" => "2004"
                        "volumen" => "117"
                        "numero" => "2"
                        "paginaInicial" => "232"
                        "paginaFinal" => "238"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15047128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.jss.2004.01.013"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;jss&#46;2004&#46;01&#46;013"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib45"
              "etiqueta" => "45"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibrosis&#44; gene expression and orbital inflammatory disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              JT Rosenbaum \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              D Choi \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              DJ Wilson \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              HE Grossniklaus \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              CA Harrington \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              RA Dailey \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1136/bjophthalmol-2015-306614"
                      "Revista" => array:7 [
                        "tituloSerie" => "Br J Ophthalmol"
                        "fecha" => "2015"
                        "volumen" => "99"
                        "numero" => "10"
                        "paginaInicial" => "1424"
                        "paginaFinal" => "1429"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26038391"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1136/bjophthalmol-2015-306614"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1136&#47;bjophthalmol-2015-306614"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib46"
              "etiqueta" => "46"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fibronectin peptides as potential regulators of hepatic fibrosis through apoptosis of hepatic stellate cells"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              T Modol \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              N Brice \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M Ruiz de Galarreta \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              A Garcia Garzon \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              MJ Iraburu \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              JJ Martinez-Irujo \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1002/jcp.24714"
                      "Revista" => array:7 [
                        "tituloSerie" => "Journal of cellular physiology"
                        "fecha" => "2015"
                        "volumen" => "230"
                        "numero" => "3"
                        "paginaInicial" => "546"
                        "paginaFinal" => "553"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24976518"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1002/jcp.24714"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1002&#47;jcp&#46;24714"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib47"
              "etiqueta" => "47"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "In vivo co-distribution of fibronectin and actin fibers in granulation tissue&#58; immunofluorescence and electron microscope studies of the fibronexus at the myofibroblast surface"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              DW Singer&#44; II&#44; Kawka \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              DM Kazazis \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              RA Clark \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1083/jcb.98.6.2091"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Cell Biol"
                        "fecha" => "1984"
                        "volumen" => "98"
                        "numero" => "6"
                        "paginaInicial" => "2091"
                        "paginaFinal" => "2106"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6373789"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1083/jcb.98.6.2091"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1083&#47;jcb&#46;98&#46;6&#46;2091"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib48"
              "etiqueta" => "48"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Myofibroblasts exhibit enhanced fibronectin assembly that is intrinsic to their contractile phenotype"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              EE Torr \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              CR Ngam \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              K Bernau \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              B Tomasini-Johansson \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              B Acton \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              N Sandbo \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1074/jbc.M114.606186"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Biol Chem"
                        "fecha" => "2015 Mar 13"
                        "volumen" => "290"
                        "numero" => "11"
                        "paginaInicial" => "6951"
                        "paginaFinal" => "6961"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25627685"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1074/jbc.M114.606186"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1074&#47;jbc&#46;M114&#46;606186"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
              "identificador" => "bib49"
              "etiqueta" => "49"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pathogenesis of liver fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => """
                              V Hernandez-Gea \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              SL Friedman \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1146/annurev-pathol-011110-130246"
                      "Revista" => array:6 [
                        "tituloSerie" => "Annu Rev Pathol"
                        "fecha" => "2011"
                        "volumen" => "6"
                        "paginaInicial" => "425"
                        "paginaFinal" => "456"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21073339"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1146/annurev-pathol-011110-130246"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1146&#47;annurev-pathol-011110-130246"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
              "identificador" => "bib50"
              "etiqueta" => "50"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inhibition of fibronectin deposition improves experimental liver fibrosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              E Altrock \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              C Sens \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Wuerfel \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              M Vasel \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              N Kawelke \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              S Dooley \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jhep.2014.06.010"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Hepatol"
                        "fecha" => "2015"
                        "volumen" => "62"
                        "numero" => "3"
                        "paginaInicial" => "625"
                        "paginaFinal" => "633"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24946284"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.jhep.2014.06.010"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;jhep&#46;2014&#46;06&#46;010"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib51"
              "etiqueta" => "51"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Frozen shoulder&#58; A systematic review of therapeutic options"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              HS Uppal \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              JP Evans \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              C Smith \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.5312/wjo.v6.i2.263"
                      "Revista" => array:7 [
                        "tituloSerie" => "World J Orthop"
                        "fecha" => "2015"
                        "volumen" => "6"
                        "numero" => "2"
                        "paginaInicial" => "263"
                        "paginaFinal" => "268"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25793166"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.5312/wjo.v6.i2.263"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;5312&#47;wjo&#46;v6&#46;i2&#46;263"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
              "identificador" => "bib52"
              "etiqueta" => "52"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adhesive capsulitis&#58; human fibroblast response to shoulder joint aspirate from patients with stage II disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              H Mullett \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              D Byrne \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              J Colville \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jse.2006.08.001"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Shoulder Elbow Surg"
                        "fecha" => "2007"
                        "volumen" => "16"
                        "numero" => "3"
                        "paginaInicial" => "290"
                        "paginaFinal" => "294"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17240170"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.jse.2006.08.001"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;jse&#46;2006&#46;08&#46;001"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
              "identificador" => "bib53"
              "etiqueta" => "53"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Enhanced expression of neuronal proteins in idiopathic frozen shoulder"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              Y Xu \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              F Bonar \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              GA Murrell \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jse.2011.08.046"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Shoulder Elbow Surg"
                        "fecha" => "2012"
                        "volumen" => "21"
                        "numero" => "10"
                        "paginaInicial" => "1391"
                        "paginaFinal" => "1397"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22005128"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.jse.2011.08.046"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;jse&#46;2011&#46;08&#46;046"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            53 => array:3 [
              "identificador" => "bib54"
              "etiqueta" => "54"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of vascular endothelial growth factor and angiogenesis in the diabetic frozen shoulder"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => """
                              JD Ryu \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              PA Kirpalani \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              JM Kim \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              KH Nam \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              CW Han \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              SH Han \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Journal of shoulder and elbow surgery &#47; American Shoulder and Elbow Surgeons &#91;et al"
                        "fecha" => "2006"
                        "volumen" => "15"
                        "numero" => "6"
                        "paginaInicial" => "679"
                        "paginaFinal" => "685"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            54 => array:3 [
              "identificador" => "bib55"
              "etiqueta" => "55"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Cytogenetic analysis of the pathology of frozen shoulder"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => """
                              B Kabbabe \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              S Ramkumar \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M Richardson \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.4103/0973-6042.76966"
                      "Revista" => array:7 [
                        "tituloSerie" => "Int J Shoulder Surg"
                        "fecha" => "2010"
                        "volumen" => "4"
                        "numero" => "3"
                        "paginaInicial" => "75"
                        "paginaFinal" => "78"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21472067"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.4103/0973-6042.76966"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;4103&#47;0973-6042&#46;76966"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            55 => array:3 [
              "identificador" => "bib56"
              "etiqueta" => "56"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inducement of mitogen-activated protein kinases in frozen shoulders"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              K Kanbe \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              K Inoue \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              Y Inoue \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              Q Chen \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1007/s00776-008-1295-6"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Orthop Sci"
                        "fecha" => "2009"
                        "volumen" => "14"
                        "numero" => "1"
                        "paginaInicial" => "56"
                        "paginaFinal" => "61"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19214689"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1007/s00776-008-1295-6"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1007&#47;s00776-008-1295-6"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            56 => array:3 [
              "identificador" => "bib57"
              "etiqueta" => "57"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Hyaluronan modulates cell proliferation and mRNA expression of adhesion-related procollagens and cytokines in glenohumeral synovial&#47;capsular fibroblasts in adhesive capsulitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              M Nago \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              Y Mitsui \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              M Gotoh \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              K Nakama \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              I Shirachi \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              F Higuchi \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1002/jor.21075"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Orthop Res"
                        "fecha" => "2010"
                        "volumen" => "28"
                        "numero" => "6"
                        "paginaInicial" => "726"
                        "paginaFinal" => "731"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20058278"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1002/jor.21075"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1002&#47;jor&#46;21075"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            57 => array:3 [
              "identificador" => "bib58"
              "etiqueta" => "58"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Expression of growth factors&#44; cytokines and matrix metalloproteinases in frozen shoulder"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => """
                              TD Bunker \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              J Reilly \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              KS Baird \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              DL Hamblen \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1302/0301-620x.82b5.9888"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Bone Joint Surg Br"
                        "fecha" => "2000"
                        "volumen" => "82"
                        "numero" => "5"
                        "paginaInicial" => "768"
                        "paginaFinal" => "773"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10963182"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1302/0301-620x.82b5.9888"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1302&#47;0301-620X&#46;82B5&#46;9888"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            58 => array:3 [
              "identificador" => "bib59"
              "etiqueta" => "59"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Inflammatory cytokines are overexpressed in the subacromial bursa of frozen shoulder"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              YM Lho \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              E Ha \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              CH Cho \n
                              \t\t\t\t\t\t\t\t
                              """
                            3 => """
                              KS Song \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              BW Min \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              KC Bae \n
                              \t\t\t\t\t\t\t\t
                              """
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:2 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jse.2012.06.014"
                      "Revista" => array:7 [
                        "tituloSerie" => "J Shoulder Elbow Surg"
                        "fecha" => "2013"
                        "volumen" => "22"
                        "numero" => "5"
                        "paginaInicial" => "666"
                        "paginaFinal" => "672"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22999851"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                    1 => array:2 [
                      "doi" => "10.1016/j.jse.2012.06.014"
                      "WWW" => array:1 [
                        "link" => "http&#58;&#47;&#47;dx&#46;doi&#46;org&#47;10&#46;1016&#47;j&#46;jse&#46;2012&#46;06&#46;014"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
    "agradecimientos" => array:1 [
      0 => array:4 [
        "identificador" => "xack638307"
        "titulo" => "ACKNOWLEDGMENTS"
        "texto" => "<p id="para340" class="elsevierStylePara elsevierViewall">This study was supported by grants and fellowships from the Conselho Nacional de Desenvolvimento Cient&#237;fico e Tecnol&#243;gico &#40;CNPQ&#59; MC and MACS&#41; and the Funda&#231;&#227;o de Amparo &#224; Pesquisa do Estado de S&#227;o Paulo &#40;FAPESP&#59; MC and MFL&#41;&#46; We are grateful to Sintia Iole Belangero&#44; Ph&#46; D&#44; for the scientific project support&#46;</p>"
        "vista" => "all"
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/18075932/0000007100000006/v1_202211291053/S1807593222010912/v1_202211291053/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/18075932/0000007100000006/v1_202211291053/S1807593222010912/v1_202211291053/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222010912?idApp=UINPBA00004N"
]

Article information

ISSN: 18075932
Original language: English

DOI:10.6061/clinics/2016(06)07

The statistics are updated each day

Year/Month	Html	Pdf	Total

2024 November	9	2	11
2024 October	50	18	68
2024 September	40	12	52
2024 August	46	13	59
2024 July	41	13	54
2024 June	50	9	59
2024 May	58	12	70
2024 April	51	6	57
2024 March	25	18	43
2024 February	23	13	36
2024 January	16	15	31
2023 December	15	18	33
2023 November	24	16	40
2023 October	33	21	54
2023 September	36	8	44
2023 August	20	7	27
2023 July	12	7	19
2023 June	13	1	14
2023 May	31	0	31
2023 April	27	1	28
2023 March	10	3	13
2023 February	3	0	3
2023 January	3	1	4
2022 December	18	4	22
2022 November	1	0	1

Show all

Indexed in:

Follow us:

Statistics

Indexed in:

Follow us:

Statistics

Subscribe to our newsletter