Mechanical ventilation in patients in the intensive care unit of a general university hospital in southern Brazil: an epidemiological study

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"aff4" ] ] ] 6 => array:3 [ "nombre" => "Mary Clarisse" "apellidos" => "Bozzetti" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "II" "identificador" => "aff2" ] 1 => array:2 [ "etiqueta" => "III" "identificador" => "aff3" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Universidade Federal do Rio Grande do Sul, Departamento de Medicina Interna" "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Departamento de Medicina Social, Porto Alegre/RS, Brazil" "etiqueta" => "II" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Hospital de Clínicas de Porto Alegre, Divisão de Cuidados Intensivos, Porto Alegre/RS, Brazil" "etiqueta" => "III" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Universidade Federal do Rio Grande do Sul, Instituto de Matemática, Departamento de Estatística, Porto Alegre/RS, Brazil" "etiqueta" => "IV" "identificador" => "aff4" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "corresponding author" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1-" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 700 "Ancho" => 700 "Tamanyo" => 46252 ] ] "descripcion" => array:1 [ "en" => "Figure 1. Kaplan-Meier curves of the probability of survival over time for mechanical ventilation." ] ] ] "textoCompleto" => "INTRODUCTIONAcute respiratory failure (ARF) is a common cause of admission to the intensive care unit (ICU) that occurs for several reasons, including pulmonary disease, neuromuscular disease, shock and the need for airway protection or temporary respiratory support after major surgery. For patients with ARF, mechanical ventilation (MV) is the cornerstone of management <a class="elsevierStyleCrossRef" href="#bib1">1</a>,<a class="elsevierStyleCrossRef" href="#bib2">2</a>. Patients admitted to ICUs who need MV are expected to have higher mortality rates compared with those who do not require respiratory support <a class="elsevierStyleCrossRef" href="#bib3">3</a>.Despite advances in the management of ARF with MV, mortality has not decreased significantly and costs remain high <a class="elsevierStyleCrossRef" href="#bib4">4</a><a class="elsevierStyleCrossRef" href="#bib5">5</a><a class="elsevierStyleCrossRef" href="#bib6">6</a><a class="elsevierStyleCrossRef" href="#bib7">7</a><a class="elsevierStyleCrossRef" href="#bib8">8</a><a class="elsevierStyleCrossRef" href="#bib9">9</a>. Knowledge of the epidemiology of patients requiring MV, including mortality rates and mortality risk factors, may help to improve therapeutic strategies, as might counseling of patients or their relatives <a class="elsevierStyleCrossRef" href="#bib10">10</a>. Esteban et al. found that mortality depends on (i) factors present at the start of MV, (ii) factors developed during the course of MV, and (iii) factors related to patients' management <a class="elsevierStyleCrossRef" href="#bib10">10</a>. Other studies have addressed the specific risk factors in such patients, including multiple organ dysfunction, age, the Simplified Acute Physiology Score II (SAPS II), nonpulmonary sources of respiratory failure, and immunosuppression <a class="elsevierStyleCrossRef" href="#bib3">3</a>,<a class="elsevierStyleCrossRef" href="#bib5">5</a>,.Knowledge of the epidemiological profile of patients with ARF requiring MV in Latin America is scarce, particularly in Brazil. In particular, Tomicic et al. <a class="elsevierStyleCrossRef" href="#bib14">14</a> explored the characteristics and mortality risk factors of 156 patients who required MV in 19 ICUs in Chile, and Azevedo et al. <a class="elsevierStyleCrossRef" href="#bib15">15</a> evaluated 773 adult patients admitted to 45 ICUs in Brazil over a two-month period who required MV for more than 24 hours. Further studies are needed to improve the understanding of patients who require MV in developing countries in which there is limited resource allocation. Therefore, our study aimed to determine the characteristics, the frequency and the mortality rates of patients who needed MV in southern Brazil.MATERIALS AND METHODSStudy designThis prospective cohort study was conducted between March 1st, 2004 and April 30th, 2007, in the ICU of the Hospital de Clínicas de Porto Alegre, a teaching hospital in the city of Porto Alegre, in southern Brazil. In Porto Alegre and its metropolitan area, the estimated population size is 1,436,123 and 4,063,886 inhabitants, respectively.The ICU has 24 beds and is assisted by one doctor and nurse assistant for every five patients and by one nurse technician for every two patients during the day. In addition, one physiotherapist and one medical resident aid every ten and two patients, respectively. During the night and on weekends, one doctor and nurse assistant help every ten patients, one nurse technician helps every two patients, and one medical resident helps every ten patients. At the time of the study, the ICU occupancy rate was 90%.Data collectionPatients admitted to the ICU who were ≥18 years old were included in the study after completing 24 consecutive hours on either non-invasive MV (NIMV) or invasive MV (IMV). Patients were excluded if they did not complete 24 hours on MV or did not require it. Each patient was followed during the course of MV for a period of 28 days or until death. All information was collected by trained personnel through a standardized questionnaire.Study variablesThe following information was obtained:Outcome variables(i) the overall mortality rate, defined as the mortality rate of all patients admitted to the ICU during the period of the study; (ii) the specific mortality rate, defined as the total number of deaths among MV patients during the study period; and (iii) the length of stay (LOS) in the ICU and hospital.Independent variablesAge; gender; the Acute Physiology and Chronic Health Evaluation II (APACHE II) score obtained within the first 24 hours of admission; patient status (clinical or surgical); the modality of respiratory support (NIMV or IMV); the main reason(s) for MV; tracheostomy; and previous health status, including hepatic, renal, cardiovascular, neurological, gastrointestinal and hematologic failure <a class="elsevierStyleCrossRef" href="#bib16">16</a>. Data were collected regarding events that developed during the MV period, including acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) <a class="elsevierStyleCrossRef" href="#bib17">17</a>; barotrauma; sepsis; ventilator-acquired pneumonia (VAP) <a class="elsevierStyleCrossRef" href="#bib18">18</a>; organ failure <a class="elsevierStyleCrossRef" href="#bib16">16</a>; weaning failure; and use of drugs such as sedatives, analgesics, and vasoactive or neuromuscular blockers. Weaning failure was defined as a need for reintubation and IMV within the first 48 hours after extubation. Data on arterial blood gases, chest X-rays, ventilatory parameters and modes of MV were also recorded.Statistical analysisData analysis was performed considering factors present at the start and/or occurring over the course of MV. Categorical variables were coded as dummy variables to compare all categories with the one having the lower mortality. A univariate analysis was performed to identify the variables associated with mortality using either the chi-squared (χ2) test (categorical variables) or Student's t test (continuous variables). Continuous variables were also compared using ANOVA and the post hoc Tukey test. A χ2 test for linear trends was used to relate mortality rates to the number of organ failures. A Kaplan-Meier analysis was used to determine the probability of survival during MV. A Cox proportional hazards model was conducted using the PHREG procedure from SAS to identify factors independently associated with mortality. In this analysis, the outcome was defined as the time, in days, between the beginning of MV and death. The criteria for variables entering the multivariable model was p<0.25 in the univariable models and/or clinical relevance. Variables were excluded from the model one at a time, keeping those significant at 5% in the final model. The statistical analysis was performed using SPSS® version 18.0 and SAS® version 9.2. The analysis was reviewed by a consultant with formal statistical training and experience. His analysis was performed after all data collection and after the analysis had been independently carried out by another investigator.EthicsThe study was approved by the hospital's research ethics committee (number: 03-502) with an informed consent waiver. The research team also signed an institutional document ensuring full confidentiality of the patients' records.RESULTSA total of 2,430 patients were admitted to the ICU during the study period, and 1,115 (46%) were included in the study.<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a> describes the characteristics of the studied population. The most common reasons for initiation of MV were sepsis (41.8%), shock (37.8%), pneumonia (37%) and ALI/ARDS (15%). The frequency of IMV was 97.7%, which included patients who started on this mode of ventilation at the beginning of the study (92.6%) and those who failed NIMV (5.1%). The rate of weaning failure for IMV was 29.4%.<elsevierMultimedia ident="tbl1"></elsevierMultimedia>Regarding NIMV, 7.4% (n=83) patients initiated this mode of ventilatory support, but only 2.3% (n=26) remained on NIMV during the entire course of MV. Therefore, the failure rate of NIMV was 68.7%. The major reasons for the use of NIMV were pneumonia (49%; n=41), sepsis (31%; n=26), ALI/ARDS (17%; n=14), and chronic obstructive pulmonary disease (COPD) (15%; n=13). The rate of NIMV failure was 79% in ALI/ARDS, 61.5% in pneumonia, 73% in sepsis, and 38.5% in COPD. Additionally, 10.4% of the patients needed tracheostomy and 70.1% (782/1115) needed vasopressors.The ventilator modes and the monitored respiratory variables on days 1, 2 and 3 (mean values) of IMV in all patients as well as in the COPD and ARDS groups in particular are presented in <a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>. Assisted/controlled pressure ventilation was the most commonly used mode of IMV in all groups. <a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a> describes the outcomes among the COPD, ARDS and other patient (non-COPD and non-ARDS) groups. Patients with ARDS presented a longer duration of IMV compared with those with COPD and other patients (12.1±8.7 vs. 8.9±5.5 and 9.3±7.3, p=0.01). The LOS values in the ICU and hospital were similar among groups.<elsevierMultimedia ident="tbl2"></elsevierMultimedia><elsevierMultimedia ident="tbl3"></elsevierMultimedia>The overall and the specific mortality rates of MV patients were 23% (564/2430) and 51% (564/1115), respectively. Regarding COPD patients in particular, the mortality rate was 26.7% (16/60). In ARDS patients, the mortality rate was 66% (204/307). The mortality rate in patients who developed ARDS during MV (71%; 126/180) was higher, but not significantly different (p=0.15), compared with the rate in those with ARDS as the cause of MV (63%; 78/127). <a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a> presents the survival curves for the ARDS and COPD groups and also for the other studied patients (p<0.001).<elsevierMultimedia ident="fig1"></elsevierMultimedia>The main events that occurred during MV were sepsis (n=210; 18.8%), VAP (n=181; 16%), ARDS (n=180; 16%), and barotrauma (n=32; 2.8%). The mortality rates are shown in <a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a>; these rates increased as the number of failing organs increased. There was a high percentage of patients with failure of three or more organs in the cohort (45%), especially among patients with ARDS (52%) and in COPD patients (15%). In addition, patients developed the following types of organ failure during the course of MV: renal (n=290; 26%), cardiovascular (n=227; 20.4%), coagulopathic (n=201; 18%), neurological (n=115; 10%) and hepatic (n=86; 7.7%).<elsevierMultimedia ident="tbl4"></elsevierMultimedia>The factors independently associated with hospital mortality are illustrated in <a class="elsevierStyleCrossRef" href="#tbl5">Table 5</a>. The conditions present at the beginning of MV were age; the APACHE II score; renal and neurological failure; and, as causes of MV, ALI/ARDS and sepsis. The conditions occurring over the course of MV were ALI/ARDS; sepsis; and renal, cardiovascular, and hepatic failure. The following variables were negatively associated with mortality: COPD exacerbation and pneumonia as causes of MV, in addition to VAP.<elsevierMultimedia ident="tbl5"></elsevierMultimedia>DISCUSSIONThe main findings of our study were as follows: (i) the hospital mortality rate of patients who required MV was 51% and (ii) the factors associated with increased mortality included conditions present at the start of MV as well as conditions that occurred during mechanical support.The frequency of MV in our study was in agreement with frequencies described in other publications <a class="elsevierStyleCrossRef" href="#bib3">3</a>,<a class="elsevierStyleCrossRef" href="#bib11">11</a>. Carson et al. showed that the incidence of MV increased by 11% over 7 years, with a higher burden of comorbidities and fewer discharges to home <a class="elsevierStyleCrossRef" href="#bib8">8</a>. Additionally, assisted/controlled pressure ventilation was the most commonly used mode of IMV in all groups in the current study and this observation was similar to the results of another study <a class="elsevierStyleCrossRef" href="#bib10">10</a>.The rate of mortality in the present study was higher than rates in several multicenter prospective cohort studies, which ranged from 30.7-42% <a class="elsevierStyleCrossRef" href="#bib5">5</a>,<a class="elsevierStyleCrossRef" href="#bib8">8</a>,<a class="elsevierStyleCrossRef" href="#bib10">10</a>,<a class="elsevierStyleCrossRef" href="#bib11">11</a>,<a class="elsevierStyleCrossRef" href="#bib14">14</a>,<a class="elsevierStyleCrossRef" href="#bib15">15</a>,<a class="elsevierStyleCrossRef" href="#bib19">19</a>. In one Brazilian multicenter study by Azevedo et al., the hospital mortality rate was 42% <a class="elsevierStyleCrossRef" href="#bib15">15</a>. When comparing the mortality rates in our study with those in the literature, several aspects must be taken into account. These aspects include different methodologies (e.g., inclusion criteria, characteristics of the population) and different severities of illness. Our study specifically showed that APACHE II score, organ failures, ALI/ARDS, sepsis and age were independently associated with hospital mortality. Mortality risk factors have also been the focus of several investigations <a class="elsevierStyleCrossRef" href="#bib3">3</a>,<a class="elsevierStyleCrossRef" href="#bib5">5</a>,<a class="elsevierStyleCrossRef" href="#bib8">8</a>,<a class="elsevierStyleCrossRef" href="#bib10">10</a>,<a class="elsevierStyleCrossRef" href="#bib11">11</a>,. The high severity of illness in our cohort may have contributed to the elevated mortality rates. In this study, the mean APACHE II score was higher when compared with scores in other studies <a class="elsevierStyleCrossRef" href="#bib5">5</a>,<a class="elsevierStyleCrossRef" href="#bib14">14</a>. Studies have also evaluated the severity of illness using the SAPS II score, which is difficult to compare across studies <a class="elsevierStyleCrossRef" href="#bib10">10</a>,<a class="elsevierStyleCrossRef" href="#bib11">11</a>,<a class="elsevierStyleCrossRef" href="#bib15">15</a>. Further evidence that our population had more severe illness was the higher percentage of patients with failure of three or more organs (45%) compared with the percentage in another study, in which 13% of the patients had this condition <a class="elsevierStyleCrossRef" href="#bib13">13</a>. Other reasons for higher mortality in our study were the reasons for initiation of MV, which included sepsis (41.8%), shock (37.8%), pneumonia (37%) and ALI/ARDS (15%). Azevedo et al. showed that the main causes included pneumonia (27%), neurological failure (19%) and non-pulmonary sepsis (12%) <a class="elsevierStyleCrossRef" href="#bib15">15</a>. In addition, Esteban et al. reported different percentages for the main causes of MV, such as postoperative patients <a class="elsevierStyleCrossRef" href="#bib10">10</a>. Taken together, these disparities probably resulted in a less severely ill population with lower mortality rates <a class="elsevierStyleCrossRef" href="#bib10">10</a>,<a class="elsevierStyleCrossRef" href="#bib15">15</a>.The mortality of ARDS patients observed in our study was high. One reason for this high mortality rate in ARDS patients was the severity of illness, with a mean APACHE II score of 23.6. Furthermore, 42.5% of ARDS patients had failure of three or more organs. Additionally, in ARDS patients, the tidal volumes were higher than those suggested in the context of a lung-protective strategy, which reduces mortality in these patients <a class="elsevierStyleCrossRef" href="#bib20">20</a>. During the period of our study, a lung-protective strategy was not completely incorporated into our practice, which also could have affected the mortality rate. Another reason for discrepancy could be that in our study, we used a previously established criterion for the classification of ALI/ARDS <a class="elsevierStyleCrossRef" href="#bib17">17</a>, whereas mortality rates in other studies may have been influenced by the recent new Berlin definition of this syndrome <a class="elsevierStyleCrossRef" href="#bib21">21</a>. In Brazil in particular, using the Berlin definition, Azevedo et al. reported a hospital mortality rate of 52% <a class="elsevierStyleCrossRef" href="#bib15">15</a>. A systematic review found that ARDS mortality has remained static, at 44%, for observational studies since the 1994 consensus definition of this syndrome <a class="elsevierStyleCrossRef" href="#bib22">22</a>,<a class="elsevierStyleCrossRef" href="#bib23">23</a>. For example, in the ALIEN study, the hospital mortality rate was 47.8% <a class="elsevierStyleCrossRef" href="#bib24">24</a>. In the setting of low-to-middle countries, best-practices strategies should be employed to reduce the mortality rates in ARDS patients.Our finding that age was independently associated with mortality in MV patients has also been described in previous studies <a class="elsevierStyleCrossRef" href="#bib8">8</a>. In our study, COPD and pneumonia as causes of MV, in addition to VAP, were found to be negatively associated with mortality in these patients. COPD was also found to be protective by Esteban et al. <a class="elsevierStyleCrossRef" href="#bib10">10</a>. One possible explanation for the negative association of COPD and hospital mortality in the present study may be that such patients were less severely ill than those without COPD were; these patients presented fewer morbidities during the MV period (nonrespiratory system dysfunction). It should be noted that few patients had COPD exacerbation as a cause of MV and admission to the ICU in this study. Pneumonia as a cause of MV was also found to be negatively related to mortality, which may have been due to a lower percentage of failure of three or more organs in this group of patients. In two studies that examined risk factors for needing ventilatory support, pneumonia was not associated with mortality after the multivariate analysis <a class="elsevierStyleCrossRef" href="#bib6">6</a>,<a class="elsevierStyleCrossRef" href="#bib10">10</a>. Studies of fatality rates comparing patients with and without VAP have generated contradictory results as to whether this condition increases mortality <a class="elsevierStyleCrossRef" href="#bib10">10</a>,. It should be noted that the present study was not designed to examine only VAP patients, but rather included a myriad of patients requiring MV. In addition, according to our analysis, VAP patients had a lower percentage of organ failure and of sepsis as a cause of MV compared with patients without VAP.Our study showed a lower frequency of NIMV compared with IMV. Only 2.3% of patients remained on NIMV during the entire course of MV, which could be explained by our overwhelming patient demand for the ICU; in fact, many patients who needed NIMV remained in the emergency department or in the hospital ward. Our percentage of NIMV use was lower compared with percentages in other studies <a class="elsevierStyleCrossRef" href="#bib15">15</a>,<a class="elsevierStyleCrossRef" href="#bib19">19</a>,<a class="elsevierStyleCrossRef" href="#bib28">28</a>,<a class="elsevierStyleCrossRef" href="#bib29">29</a>. For example, a recent Brazilian study had higher percentage of NIMV patients, which could have led to different outcomes <a class="elsevierStyleCrossRef" href="#bib15">15</a>. Additionally, the percentage of NIMV failure was higher in our study than in recent investigations <a class="elsevierStyleCrossRef" href="#bib15">15</a>,<a class="elsevierStyleCrossRef" href="#bib19">19</a>,<a class="elsevierStyleCrossRef" href="#bib29">29</a>, which may have been related to the difference in the severity of illness of the patients between the studies. More specifically, there was an important difference in the main reasons for the use of NIMV. Our study also found a higher percentage of patients with pneumonia, sepsis and ALI/ARDS and a small number of patients with a greater demonstrated benefit regarding COPD exacerbation and acute pulmonary edema <a class="elsevierStyleCrossRef" href="#bib29">29</a><a class="elsevierStyleCrossRef" href="#bib30">30</a><a class="elsevierStyleCrossRef" href="#bib31">31</a>.The percentage of weaning failure in the present study was higher (29.4%) compared with percentages in the literature (5-20%) <a class="elsevierStyleCrossRef" href="#bib15">15</a>,<a class="elsevierStyleCrossRef" href="#bib32">32</a>. Possible reasons may be related to (i) the fact that certain patients at high risk of weaning failure could not have used NIMV immediately after extubation and (ii) the lack of a weaning protocol. Although recognizing that a protocol would not necessarily be crucial, we think that it could have helped, considering that our ICU is a multidisciplinary unit with a heterogeneous patient population. Within the last few years, we have been using a weaning protocol including NIMV in high-risk patients, sharper surveillance regarding sedation, and physiotherapist participation in patients' weaning process. Indeed, recent data have shown that our percentage of weaning failure has dropped to 21% <a class="elsevierStyleCrossRef" href="#bib32">32</a>.The limitations of our study include that (i) the data were obtained from one ICU, so the results may not be generalizable to other patients who require MV; (ii) the ICU was at a tertiary university hospital that admits patients with more severe illness/conditions, so the interpretation of the results may be different from that in other studies whose patients did not have similar disease severity; and (iii) comorbidities, such as neoplasia, AIDS, cirrhosis, and chronic renal failure, were not studied, so the influence of such conditions on the mortality rates of the studied population could not be estimated. Taking into account these limitations, to the best of our knowledge, this large study best describes the factors associated with mortality in ICU patients who required MV.The hospital mortality rate of MV patients in our study was higher than rates reported in the literature, which may have been related to the severity of illness of the studied population. Furthermore, the factors associated with increased mortality included conditions present at the beginning of MV as well as conditions that occurred during mechanical support. The epidemiological aspects of MV patients explored in our investigation could enhance knowledge of such patients in South America. To the best of our knowledge, this large cohort study of MV patients on this continent may contribute to a more global understanding regarding the use of MV. In developing countries such as Brazil in particular, the limited availability of ICU beds results in the admission of patients with more severe illness, which may account for the higher mortality rates. These observations should be considered when comparing the mortality of such patients among countries under diverse socioeconomic conditions.AUTHOR CONTRIBUTIONSFialkow L designed the study, participated in the acquisition of the data, performed the statistical analyses of the data and wrote the manuscript. Farenzena M designed the study and participated in the acquisition of the data. Wawrzeniak IC conceived the study, analyzed and interpreted the data and wrote the manuscript. Brauner JS supervised the project, participated in the acquisition of the data, conceived the study, and analyzed and interpreted the data. Vieira SR supervised the project, conceived the study, participated in the acquisition of the data, and analyzed and interpreted the data. Vigo A performed the statistical analyses of the data. Bozzetti MC performed the statistical analyses of the data and wrote the manuscript. All authors contributed extensively to the work presented in this manuscript and took responsibility for reading and checking the text before submission." "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xpalclavsec1580485" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "MATERIALS AND METHODS" "secciones" => array:5 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Study design" ] 1 => array:2 [ "identificador" => "cesec40" "titulo" => "Data collection" ] 2 => array:3 [ "identificador" => "cesec50" "titulo" => "Study variables" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "cesec60" "titulo" => "Outcome variables" ] 1 => array:2 [ "identificador" => "cesec70" "titulo" => "Independent variables" ] ] ] 3 => array:2 [ "identificador" => "cesec80" "titulo" => "Statistical analysis" ] 4 => array:2 [ "identificador" => "cesec90" "titulo" => "Ethics" ] ] ] 3 => array:2 [ "identificador" => "cesec100" "titulo" => "RESULTS" ] 4 => array:2 [ "identificador" => "cesec110" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec120" "titulo" => "AUTHOR CONTRIBUTIONS" ] 6 => array:2 [ "identificador" => "xack638321" "titulo" => "ACKNOWLEDGMENTS" ] 7 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-09-26" "fechaAceptado" => "2016-01-21" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1580485" "palabras" => array:5 [ 0 => "Acute Respiratory Failure" 1 => "Mechanical Ventilation" 2 => "Mortality" 3 => "Risk Factors" 4 => "Epidemiology" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "OBJECTIVES:To determine the characteristics, the frequency and the mortality rates of patients needing mechanical ventilation and to identify the risk factors associated with mortality in the intensive care unit (ICU) of a general university hospital in southern Brazil. METHOD:Prospective cohort study in patients admitted to the ICU who needed mechanical ventilation for at least 24 hours between March 2004 and April 2007. RESULTS:A total of 1,115 patients admitted to the ICU needed mechanical ventilation. The mortality rate was 51%. The mean age (± standard deviation) was 57±18 years, and the mean Acute Physiology and Chronic Health Evaluation II (APACHE II) score was 22.6±8.3. The variables independently associated with mortality were (i) conditions present at the beginning of mechanical ventilation, age (hazard ratio: 1.01; p<0.001); the APACHE II score (hazard ratio: 1.01; p<0.005); acute lung injury/acute respiratory distress syndrome (hazard ratio: 1.38; p=0.009), sepsis (hazard ratio: 1.33; p=0.003), chronic obstructive pulmonary disease (hazard ratio: 0.58; p=0.042), and pneumonia (hazard ratio: 0.78; p=0.013) as causes of mechanical ventilation; and renal (hazard ratio: 1.29; p=0.011) and neurological (hazard ratio: 1.25; p=0.024) failure, and (ii) conditions occurring during the course of mechanical ventilation, acute lung injuri/acute respiratory distress syndrome (hazard ratio: 1.31; p<0.010); sepsis (hazard ratio: 1.53; p<0.001); and renal (hazard ratio: 1.75; p<0.001), cardiovascular (hazard ratio: 1.32; p≤0.009), and hepatic (hazard ratio: 1.67; p≤0.001) failure. CONCLUSIONS:This large cohort study provides a comprehensive profile of mechanical ventilation patients in South America. The mortality rate of patients who required mechanical ventilation was higher, which may have been related to the severity of illness of the patients admitted to our ICU. Risk factors for hospital mortality included conditions present at the start of mechanical ventilation conditions that occurred during mechanical support." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVES:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "METHOD:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "RESULTS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "CONCLUSIONS:" ] ] ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "No potential conflict of interest was reported." ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1-" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 700 "Ancho" => 700 "Tamanyo" => 46252 ] ] "descripcion" => array:1 [ "en" => "Figure 1. Kaplan-Meier curves of the probability of survival over time for mechanical ventilation." ] ] 1 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "APACHE II = Acute Physiology and Chronic Health Evaluation II; ALI = acute lung injury; ARDS = acute respiratory distress syndrome; COPD = chronic obstructive pulmonary disease; SD = standard deviation; 1 more than one reason for initiation of mechanical ventilation was allowed." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">Characteristic \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Number of Patients Mechanically Ventilated \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Age, median±SD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">57.2±18 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Gender, males \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">582 (52%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">APACHE II score, mean±SD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">22.6±8.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Medical/Surgical \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">771 (69%)/344 (31%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Source of admission \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Hospital ward \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">625 (56%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Emergency department \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">278 (25%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Other hospitals \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">212 (19%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Reason for the initiation of mechanical ventilation1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Sepsis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">466 (41.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Shock \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">421 (37.8%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Pneumonia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">415 (37%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ALI \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">167 (15%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ALI without ARDS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">40 (3.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ARDS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">127 (11.4%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Neurological condition \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Stroke \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">79 (7.1%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Neuromuscular disease \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">15 (1.3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Other neurological condition \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">32 (3%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">COPD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">60 (5.4%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Cardiac arrest \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">67 (6.0%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Asthma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">16 (1.6%) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Other \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">14 (1.2%) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Characteristics of the Studied Patients on Admission to the Intensive Care Unit." ] ] 2 => array:7 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "COPD = chronic obstructive pulmonary disease; ARDS = acute respiratory distress syndrome; ACP = assisted/controlled pressure ventilation; ACV = assisted/controlled volume ventilation; PSV = pressure support ventilation; CPAP = continuous positive airway pressure; SIMV = synchronized intermittent mandatory ventilation; PBW = predicted body weight; PEEP = positive end-expiratory pressure; SD = standard deviation; 1 the percentages of missing data for all patients and for the COPD and ARDS groups in particular were 12%, 11%, and 14%, respectively; 2 refers to non-COPD and non-ARDS patients." "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Overall (n=976)1 \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">COPD (n=56)a \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">ARDS (n=263)a \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Ventilator mode, no. (%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ACP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">715 (73) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">37 (66) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">200 (76) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">PSV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">195 (20) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">14 (25) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">46 (17.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">CPAP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">29 (3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">3 (5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">9 (3.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ACV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">22 (2.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">2 (4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">7 (2.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">SIMV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">15 (1.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">0 (0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">7 (2.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Monitored variable, mean±SD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Peak pressure, cm H2O \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">25.5±8.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">24±4.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">28.5±8.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Plateau pressure, cm H2O \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">21.5±5.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">20.2±4.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">23.6±6.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Tidal volume, ml/kg (PBW) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">10.5±3.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">10±3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">9±3.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Respiratory rate, breaths/min \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">20.1±4.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">19.3±3.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">21.2±4.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">PaO2/FiO2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">298.8±155 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">292.4±118 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">169±111.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">PEEP, cm H2O \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">6.6±2.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">5.8±1.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">9±4 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "Ventilator Modes and Monitored Variables on Days 1, 2 and 3 (Mean Values) of Invasive Mechanical Ventilation." ] ] 3 => array:7 [ "identificador" => "tbl3" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "MV = mechanical ventilation; LOS = length of stay; COPD = chronic obstructive pulmonary disease; ARDS = acute respiratory distress syndrome;" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Other Patients<a class="elsevierStyleCrossRef" href="#tfn5">2</a> (n=748) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">COPD (n=60) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">ARDS (n=307) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">p-value<a class="elsevierStyleCrossRef" href="#tfn6">*</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Duration of MV<a class="elsevierStyleCrossRef" href="#tfn4">1</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">9.3±7.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">8.9±5.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">12.1±8.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"><0.01<a class="elsevierStyleCrossRef" href="#tfn7">**</a> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">LOS in ICU<a class="elsevierStyleCrossRef" href="#tfn4">1</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">14.6±11.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">14.3±10 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">15.6±11.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.19 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">LOS in hospital<a class="elsevierStyleCrossRef" href="#tfn4">1</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">24.7±22.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">24.3±18.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">22.3±21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.12 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:4 [ 0 => array:3 [ "identificador" => "tfn4" "etiqueta" => "1" "nota" => "days;" ] 1 => array:3 [ "identificador" => "tfn5" "etiqueta" => "2" "nota" => "refers to non-COPD and non-ARDS patients;" ] 2 => array:3 [ "identificador" => "tfn6" "etiqueta" => "*" "nota" => "p-value for ANOVA;" ] 3 => array:3 [ "identificador" => "tfn7" "etiqueta" => "**" "nota" => "p<0.001 for ANOVA (and p<0.05 for the Tukey test for the following comparisons: COPD vs. ARDS patients and other patients vs. ARDS patients)." ] ] ] "descripcion" => array:1 [ "en" => "Duration of Mechanical Ventilation and Length of Stay in the Intensive Care Unit and in the Hospital in the Studied Patients." ] ] 4 => array:7 [ "identificador" => "tbl4" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "APACHE II = Acute Physiology and Chronic Health Evaluation II; ARF = acute respiratory failure; HR = hazard ratio; CI = confidence interval;" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Group \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">n \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Age<a class="elsevierStyleCrossRef" href="#tfn9">*</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">APACHE II Score<a class="elsevierStyleCrossRef" href="#tfn9">*</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Hospital Mortality (%)<a class="elsevierStyleCrossRef" href="#tfn10">**</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">HR (95% CI)<a class="elsevierStyleCrossRef" href="#tfn10">**</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ARF+0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">138 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">57.5±17.8 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">19.0±7.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">21.0% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ARF+1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">248 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">57.1±19.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">19.9±7.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">37.1% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.91 (1.26-2.89) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ARF+2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">285 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">58.7±17.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">22.7±7.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">54.4% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">3.35 (2.26-4.99) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ARF+3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">249 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">58.5±17.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">24.9±8.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">64.7% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">4.19 (2.82-6.23) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ARF+4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">139 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">54.0±17.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">26.6±9.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">69.8% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">4.62 (3.05-6.99) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ARF+5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">52.4±19.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">25.3±7.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">73.2% \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">5.24 (3.25-8.43) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tfn9" "etiqueta" => "*" "nota" => "mean±standard deviation;" ] 1 => array:3 [ "identificador" => "tfn10" "etiqueta" => "**" "nota" => "p-value for linear trend: hospital mortality (p<0.001) and HR (p<0.001)." ] ] ] "descripcion" => array:1 [ "en" => "Severity of Illness and Hospital Mortality According to the Number of Organs with Failure." ] ] 5 => array:7 [ "identificador" => "tbl5" "etiqueta" => "Table 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "ALI/ARDS = acute lung injury/acute respiratory distress syndrome; APACHE II = Acute Physiology and Chronic Health Evaluation II; COPD = chronic obstructive pulmonary disease; MV = mechanical ventilation; VAP= ventilator-associated pneumonia;" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col">Variable \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Univariable \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Multivariable \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">HR (95% CI)<a class="elsevierStyleCrossRef" href="#tfn12">*</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">p-value<a class="elsevierStyleCrossRef" href="#tfn13">**</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">HR (95% CI)<a class="elsevierStyleCrossRef" href="#tfn12">*</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">p-value<a class="elsevierStyleCrossRef" href="#tfn13">**</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Age (years) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.07 (1.002-1.012) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.004 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.01 (1.004-1.014) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">APACHE II score \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.01 (1.007-1.02) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.01 (1.002-1.014) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.005 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Chronic use of corticosteroids \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.72 (0.53-0.97) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Failure previous to MV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Cardiovascular \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.42 (1.20-1.67) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Coagulopathic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.46 (1.21-1.77) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Hepatic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.26 (1.02-1.57) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Renal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.34 (1.14-1.59) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.0005 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.29 (1.06-1.56) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.011 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Neurological \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.13 (0.94-1.35) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.25 (1.031.52) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.024 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Cause of MV initiation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">COPD \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.42 (0.25-0.69) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.0006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.58 (0.35-0.98) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.042 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ALI/ARDS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.33 (1.08-1.65) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.008 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.38 (1.08-1.77) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.009 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Sepsis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.47 (1.25-1.73) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.33 (1.10-1.61) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.003 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Pneumonia \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.88 (0.74-1.05) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.78 (0.65-0.95) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.013 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Asthma \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.43 (0.16-1.15) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Condition occurring during MV \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Sepsis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.48 (1.22-1.79) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.53 (1.23-1.90) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">VAP \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.70 (0.53-0.91) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.009 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.62 (0.46-0.83) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">ALI/ARDS \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.42 (1.19-1.71) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.0001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.31 (1.07-1.61) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.010 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Failure \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Cardiovascular \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.54 (1.28-1.85) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.32 (1.07-1.62) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">≤0.009 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Coagulopathic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.41 (1.16-1.72) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.0006 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Hepatic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.91 (1.48-2.48) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.67 (1.26-2.21) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">≤0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Renal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.86 (1.57-2.22) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.0001 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.75 (1.42-2.15) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tfn12" "etiqueta" => "*" "nota" => "hazard ratio (HR) and 95% confidence interval (CI) for the HR;" ] 1 => array:3 [ "identificador" => "tfn13" "etiqueta" => "**" "nota" => "p-value for the analysis. In the final multivariate model, variables with p>0.05 were not included." ] ] ] "descripcion" => array:1 [ "en" => "Statistical Analysis of the Factors Associated with Mortality in Mechanical Ventilation Patients." ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:33 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "History of Mechanical Ventilation. From Vesalius to Ventilator-induced Lung Injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ AS Slutsky \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1164/rccm.201503-0421PP" "Revista" => array:7 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2015" "volumen" => "191" "numero" => "10" "paginaInicial" => "1106" "paginaFinal" => "1115" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25844759" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1164/rccm.201503-0421PP" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1164/rccm.201503-0421PP" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pressure-Controlled vs Volume-Controlled Ventilation in Acute Respiratory Failure: A Physiology-Based Narrative and Systematic Review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ N Rittayamai \n \t\t\t\t\t\t\t\t """ 1 => """ CM Katsios \n \t\t\t\t\t\t\t\t """ 2 => """ F Beloncle \n \t\t\t\t\t\t\t\t """ 3 => """ JO Friedrich \n \t\t\t\t\t\t\t\t """ 4 => """ J Mancebo \n \t\t\t\t\t\t\t\t """ 5 => """ L Brochard \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1378/chest.14-3169" "Revista" => array:7 [ "tituloSerie" => "Chest" "fecha" => "2015" "volumen" => "148" "numero" => "2" "paginaInicial" => "340" "paginaFinal" => "355" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25927671" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1378/chest.14-3169" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1378/chest.14-3169" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The epidemiology of acute respiratory failure in critically ill patients(*)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ JL Vincent \n \t\t\t\t\t\t\t\t """ 1 => """ S Akca \n \t\t\t\t\t\t\t\t """ 2 => """ A De Mendonca \n \t\t\t\t\t\t\t\t """ 3 => """ P Haji-Michael \n \t\t\t\t\t\t\t\t """ 4 => """ C Sprung \n \t\t\t\t\t\t\t\t """ 5 => """ R Moreno \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1378/chest.121.5.1602" "Revista" => array:7 [ "tituloSerie" => "Chest" "fecha" => "2002" "volumen" => "121" "numero" => "5" "paginaInicial" => "1602" "paginaFinal" => "1609" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12006450" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1378/chest.121.5.1602" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1378/chest.121.5.1602" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Hospital survival rates of patients with acute respiratory failure in modern respiratory intensive care units. 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array:2 [ "doi" => "10.1590/s1806-37132012000300012" "Revista" => array:7 [ "tituloSerie" => "Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia" "fecha" => "2012" "volumen" => "38" "numero" => "3" "paginaInicial" => "364" "paginaFinal" => "371" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22782607" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1590/s1806-37132012000300012" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1590/S1806-37132012000300012" ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack638321" "titulo" => "ACKNOWLEDGMENTS" "texto" => "We are thankful to Dr. Gregory P. Downey for his critical review of this manuscript.Financial support was provided by FIPE-HCPA (Research and Events Support Fund at Hospital de Clínicas de Porto Alegre)." "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000007100000003/v1_202211291104/S1807593222012789/v1_202211291104/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000007100000003/v1_202211291104/S1807593222012789/v1_202211291104/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222012789?idApp=UINPBA00004N"]

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Léa FialkowI,

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lfialkow@terra.com.br

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, Maurício FarenzenaI,III, Iuri Christmann WawrzeniakIII, Janete Salles BraunerIII, Sílvia Regina Rios VieiraI, Alvaro VigoIV, Mary Clarisse BozzettiII,III

I Universidade Federal do Rio Grande do Sul, Departamento de Medicina Interna

II Departamento de Medicina Social, Porto Alegre/RS, Brazil

III Hospital de Clínicas de Porto Alegre, Divisão de Cuidados Intensivos, Porto Alegre/RS, Brazil

IV Universidade Federal do Rio Grande do Sul, Instituto de Matemática, Departamento de Estatística, Porto Alegre/RS, Brazil

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          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Figure 1&#46;</span> Kaplan-Meier curves of the probability of survival over time for mechanical ventilation&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Acute respiratory failure &#40;ARF&#41; is a common cause of admission to the intensive care unit &#40;ICU&#41; that occurs for several reasons&#44; including pulmonary disease&#44; neuromuscular disease&#44; shock and the need for airway protection or temporary respiratory support after major surgery&#46; For patients with ARF&#44; mechanical ventilation &#40;MV&#41; is the cornerstone of management <a class="elsevierStyleCrossRef" href="#bib1">1</a>&#44;<a class="elsevierStyleCrossRef" href="#bib2">2</a>&#46; Patients admitted to ICUs who need MV are expected to have higher mortality rates compared with those who do not require respiratory support <a class="elsevierStyleCrossRef" href="#bib3">3</a>&#46;</p><p id="para20" class="elsevierStylePara elsevierViewall">Despite advances in the management of ARF with MV&#44; mortality has not decreased significantly and costs remain high <a class="elsevierStyleCrossRef" href="#bib4">4</a><a class="elsevierStyleCrossRef" href="#bib5">5</a><a class="elsevierStyleCrossRef" href="#bib6">6</a><a class="elsevierStyleCrossRef" href="#bib7">7</a><a class="elsevierStyleCrossRef" href="#bib8">8</a><a class="elsevierStyleCrossRef" href="#bib9">9</a>&#46; Knowledge of the epidemiology of patients requiring MV&#44; including mortality rates and mortality risk factors&#44; may help to improve therapeutic strategies&#44; as might counseling of patients or their relatives <a class="elsevierStyleCrossRef" href="#bib10">10</a>&#46; Esteban et al&#46; found that mortality depends on &#40;i&#41; factors present at the start of MV&#44; &#40;ii&#41; factors developed during the course of MV&#44; and &#40;iii&#41; factors related to patients&#39; management <a class="elsevierStyleCrossRef" href="#bib10">10</a>&#46; Other studies have addressed the specific risk factors in such patients&#44; including multiple organ dysfunction&#44; age&#44; the Simplified Acute Physiology Score II &#40;SAPS II&#41;&#44; nonpulmonary sources of respiratory failure&#44; and immunosuppression <a class="elsevierStyleCrossRef" href="#bib3">3</a>&#44;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#44;&#46;</p><p id="para30" class="elsevierStylePara elsevierViewall">Knowledge of the epidemiological profile of patients with ARF requiring MV in Latin America is scarce&#44; particularly in Brazil&#46; In particular&#44; Tomicic et al&#46; <a class="elsevierStyleCrossRef" href="#bib14">14</a> explored the characteristics and mortality risk factors of 156 patients who required MV in 19 ICUs in Chile&#44; and Azevedo et al&#46; <a class="elsevierStyleCrossRef" href="#bib15">15</a> evaluated 773 adult patients admitted to 45 ICUs in Brazil over a two-month period who required MV for more than 24 hours&#46; Further studies are needed to improve the understanding of patients who require MV in developing countries in which there is limited resource allocation&#46; Therefore&#44; our study aimed to determine the characteristics&#44; the frequency and the mortality rates of patients who needed MV in southern Brazil&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">MATERIALS AND METHODS</span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">Study design</span><p id="para40" class="elsevierStylePara elsevierViewall">This prospective cohort study was conducted between March 1<span class="elsevierStyleSup">st</span>&#44; 2004 and April 30<span class="elsevierStyleSup">th</span>&#44; 2007&#44; in the ICU of the Hospital de Cl&#237;nicas de Porto Alegre&#44; a teaching hospital in the city of Porto Alegre&#44; in southern Brazil&#46; In Porto Alegre and its metropolitan area&#44; the estimated population size is 1&#44;436&#44;123 and 4&#44;063&#44;886 inhabitants&#44; respectively&#46;</p><p id="para50" class="elsevierStylePara elsevierViewall">The ICU has 24 beds and is assisted by one doctor and nurse assistant for every five patients and by one nurse technician for every two patients during the day&#46; In addition&#44; one physiotherapist and one medical resident aid every ten and two patients&#44; respectively&#46; During the night and on weekends&#44; one doctor and nurse assistant help every ten patients&#44; one nurse technician helps every two patients&#44; and one medical resident helps every ten patients&#46; At the time of the study&#44; the ICU occupancy rate was 90&#37;&#46;</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">Data collection</span><p id="para60" class="elsevierStylePara elsevierViewall">Patients admitted to the ICU who were &#8805;18 years old were included in the study after completing 24 consecutive hours on either non-invasive MV &#40;NIMV&#41; or invasive MV &#40;IMV&#41;&#46; Patients were excluded if they did not complete 24 hours on MV or did not require it&#46; Each patient was followed during the course of MV for a period of 28 days or until death&#46; All information was collected by trained personnel through a standardized questionnaire&#46;</p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">Study variables</span><p id="para70" class="elsevierStylePara elsevierViewall">The following information was obtained&#58;</p><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">Outcome variables</span><p id="para80" class="elsevierStylePara elsevierViewall">&#40;i&#41; the overall mortality rate&#44; defined as the mortality rate of all patients admitted to the ICU during the period of the study&#59; &#40;ii&#41; the specific mortality rate&#44; defined as the total number of deaths among MV patients during the study period&#59; and &#40;iii&#41; the length of stay &#40;LOS&#41; in the ICU and hospital&#46;</p></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">Independent variables</span><p id="para90" class="elsevierStylePara elsevierViewall">Age&#59; gender&#59; the Acute Physiology and Chronic Health Evaluation II &#40;APACHE II&#41; score obtained within the first 24 hours of admission&#59; patient status &#40;clinical or surgical&#41;&#59; the modality of respiratory support &#40;NIMV or IMV&#41;&#59; the main reason&#40;s&#41; for MV&#59; tracheostomy&#59; and previous health status&#44; including hepatic&#44; renal&#44; cardiovascular&#44; neurological&#44; gastrointestinal and hematologic failure <a class="elsevierStyleCrossRef" href="#bib16">16</a>&#46; Data were collected regarding events that developed during the MV period&#44; including acute lung injury &#40;ALI&#41;&#47;acute respiratory distress syndrome &#40;ARDS&#41; <a class="elsevierStyleCrossRef" href="#bib17">17</a>&#59; barotrauma&#59; sepsis&#59; ventilator-acquired pneumonia &#40;VAP&#41; <a class="elsevierStyleCrossRef" href="#bib18">18</a>&#59; organ failure <a class="elsevierStyleCrossRef" href="#bib16">16</a>&#59; weaning failure&#59; and use of drugs such as sedatives&#44; analgesics&#44; and vasoactive or neuromuscular blockers&#46; Weaning failure was defined as a need for reintubation and IMV within the first 48 hours after extubation&#46; Data on arterial blood gases&#44; chest X-rays&#44; ventilatory parameters and modes of MV were also recorded&#46;</p></span></span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">Statistical analysis</span><p id="para100" class="elsevierStylePara elsevierViewall">Data analysis was performed considering factors present at the start and&#47;or occurring over the course of MV&#46; Categorical variables were coded as dummy variables to compare all categories with the one having the lower mortality&#46; A univariate analysis was performed to identify the variables associated with mortality using either the chi-squared &#40;&#967;<span class="elsevierStyleSup">2</span>&#41; test &#40;categorical variables&#41; or Student&#39;s <span class="elsevierStyleItalic">t</span> test &#40;continuous variables&#41;&#46; Continuous variables were also compared using ANOVA and the <span class="elsevierStyleItalic">post hoc</span> Tukey test&#46; A &#967;<span class="elsevierStyleSup">2</span> test for linear trends was used to relate mortality rates to the number of organ failures&#46; A Kaplan-Meier analysis was used to determine the probability of survival during MV&#46; A Cox proportional hazards model was conducted using the PHREG procedure from SAS to identify factors independently associated with mortality&#46; In this analysis&#44; the outcome was defined as the time&#44; in days&#44; between the beginning of MV and death&#46; The criteria for variables entering the multivariable model was <span class="elsevierStyleItalic">p</span>&#60;0&#46;25 in the univariable models and&#47;or clinical relevance&#46; Variables were excluded from the model one at a time&#44; keeping those significant at 5&#37; in the final model&#46; The statistical analysis was performed using SPSS&#174; version 18&#46;0 and SAS&#174; version 9&#46;2&#46; The analysis was reviewed by a consultant with formal statistical training and experience&#46; His analysis was performed after all data collection and after the analysis had been independently carried out by another investigator&#46;</p></span><span id="cesec90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">Ethics</span><p id="para110" class="elsevierStylePara elsevierViewall">The study was approved by the hospital&#39;s research ethics committee &#40;number&#58; 03-502&#41; with an informed consent waiver&#46; The research team also signed an institutional document ensuring full confidentiality of the patients&#39; records&#46;</p></span></span><span id="cesec100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle150">RESULTS</span><p id="para120" class="elsevierStylePara elsevierViewall">A total of 2&#44;430 patients were admitted to the ICU during the study period&#44; and 1&#44;115 &#40;46&#37;&#41; were included in the study&#46;</p><p id="para130" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a> describes the characteristics of the studied population&#46; The most common reasons for initiation of MV were sepsis &#40;41&#46;8&#37;&#41;&#44; shock &#40;37&#46;8&#37;&#41;&#44; pneumonia &#40;37&#37;&#41; and ALI&#47;ARDS &#40;15&#37;&#41;&#46; The frequency of IMV was 97&#46;7&#37;&#44; which included patients who started on this mode of ventilation at the beginning of the study &#40;92&#46;6&#37;&#41; and those who failed NIMV &#40;5&#46;1&#37;&#41;&#46; The rate of weaning failure for IMV was 29&#46;4&#37;&#46;</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><p id="para140" class="elsevierStylePara elsevierViewall">Regarding NIMV&#44; 7&#46;4&#37; &#40;n&#61;83&#41; patients initiated this mode of ventilatory support&#44; but only 2&#46;3&#37; &#40;n&#61;26&#41; remained on NIMV during the entire course of MV&#46; Therefore&#44; the failure rate of NIMV was 68&#46;7&#37;&#46; The major reasons for the use of NIMV were pneumonia &#40;49&#37;&#59; n&#61;41&#41;&#44; sepsis &#40;31&#37;&#59; n&#61;26&#41;&#44; ALI&#47;ARDS &#40;17&#37;&#59; n&#61;14&#41;&#44; and chronic obstructive pulmonary disease &#40;COPD&#41; &#40;15&#37;&#59; n&#61;13&#41;&#46; The rate of NIMV failure was 79&#37; in ALI&#47;ARDS&#44; 61&#46;5&#37; in pneumonia&#44; 73&#37; in sepsis&#44; and 38&#46;5&#37; in COPD&#46; Additionally&#44; 10&#46;4&#37; of the patients needed tracheostomy and 70&#46;1&#37; &#40;782&#47;1115&#41; needed vasopressors&#46;</p><p id="para150" class="elsevierStylePara elsevierViewall">The ventilator modes and the monitored respiratory variables on days 1&#44; 2 and 3 &#40;mean values&#41; of IMV in all patients as well as in the COPD and ARDS groups in particular are presented in <a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>&#46; Assisted&#47;controlled pressure ventilation was the most commonly used mode of IMV in all groups&#46; <a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a> describes the outcomes among the COPD&#44; ARDS and other patient &#40;non-COPD and non-ARDS&#41; groups&#46; Patients with ARDS presented a longer duration of IMV compared with those with COPD and other patients &#40;12&#46;1&#177;8&#46;7 <span class="elsevierStyleItalic">vs</span>&#46; 8&#46;9&#177;5&#46;5 and 9&#46;3&#177;7&#46;3&#44; <span class="elsevierStyleItalic">p</span>&#61;0&#46;01&#41;&#46; The LOS values in the ICU and hospital were similar among groups&#46;</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia><elsevierMultimedia ident="tbl3"></elsevierMultimedia><p id="para160" class="elsevierStylePara elsevierViewall">The overall and the specific mortality rates of MV patients were 23&#37; &#40;564&#47;2430&#41; and 51&#37; &#40;564&#47;1115&#41;&#44; respectively&#46; Regarding COPD patients in particular&#44; the mortality rate was 26&#46;7&#37; &#40;16&#47;60&#41;&#46; In ARDS patients&#44; the mortality rate was 66&#37; &#40;204&#47;307&#41;&#46; The mortality rate in patients who developed ARDS during MV &#40;71&#37;&#59; 126&#47;180&#41; was higher&#44; but not significantly different &#40;<span class="elsevierStyleItalic">p</span>&#61;0&#46;15&#41;&#44; compared with the rate in those with ARDS as the cause of MV &#40;63&#37;&#59; 78&#47;127&#41;&#46; <a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a> presents the survival curves for the ARDS and COPD groups and also for the other studied patients &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&#46;</p><elsevierMultimedia ident="fig1"></elsevierMultimedia><p id="para170" class="elsevierStylePara elsevierViewall">The main events that occurred during MV were sepsis &#40;n&#61;210&#59; 18&#46;8&#37;&#41;&#44; VAP &#40;n&#61;181&#59; 16&#37;&#41;&#44; ARDS &#40;n&#61;180&#59; 16&#37;&#41;&#44; and barotrauma &#40;n&#61;32&#59; 2&#46;8&#37;&#41;&#46; The mortality rates are shown in <a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a>&#59; these rates increased as the number of failing organs increased&#46; There was a high percentage of patients with failure of three or more organs in the cohort &#40;45&#37;&#41;&#44; especially among patients with ARDS &#40;52&#37;&#41; and in COPD patients &#40;15&#37;&#41;&#46; In addition&#44; patients developed the following types of organ failure during the course of MV&#58; renal &#40;n&#61;290&#59; 26&#37;&#41;&#44; cardiovascular &#40;n&#61;227&#59; 20&#46;4&#37;&#41;&#44; coagulopathic &#40;n&#61;201&#59; 18&#37;&#41;&#44; neurological &#40;n&#61;115&#59; 10&#37;&#41; and hepatic &#40;n&#61;86&#59; 7&#46;7&#37;&#41;&#46;</p><elsevierMultimedia ident="tbl4"></elsevierMultimedia><p id="para180" class="elsevierStylePara elsevierViewall">The factors independently associated with hospital mortality are illustrated in <a class="elsevierStyleCrossRef" href="#tbl5">Table 5</a>&#46; The conditions present at the beginning of MV were age&#59; the APACHE II score&#59; renal and neurological failure&#59; and&#44; as causes of MV&#44; ALI&#47;ARDS and sepsis&#46; The conditions occurring over the course of MV were ALI&#47;ARDS&#59; sepsis&#59; and renal&#44; cardiovascular&#44; and hepatic failure&#46; The following variables were negatively associated with mortality&#58; COPD exacerbation and pneumonia as causes of MV&#44; in addition to VAP&#46;</p><elsevierMultimedia ident="tbl5"></elsevierMultimedia></span><span id="cesec110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle160">DISCUSSION</span><p id="para190" class="elsevierStylePara elsevierViewall">The main findings of our study were as follows&#58; &#40;i&#41; the hospital mortality rate of patients who required MV was 51&#37; and &#40;ii&#41; the factors associated with increased mortality included conditions present at the start of MV as well as conditions that occurred during mechanical support&#46;</p><p id="para200" class="elsevierStylePara elsevierViewall">The frequency of MV in our study was in agreement with frequencies described in other publications <a class="elsevierStyleCrossRef" href="#bib3">3</a>&#44;<a class="elsevierStyleCrossRef" href="#bib11">11</a>&#46; Carson et al&#46; showed that the incidence of MV increased by 11&#37; over 7 years&#44; with a higher burden of comorbidities and fewer discharges to home <a class="elsevierStyleCrossRef" href="#bib8">8</a>&#46; Additionally&#44; assisted&#47;controlled pressure ventilation was the most commonly used mode of IMV in all groups in the current study and this observation was similar to the results of another study <a class="elsevierStyleCrossRef" href="#bib10">10</a>&#46;</p><p id="para210" class="elsevierStylePara elsevierViewall">The rate of mortality in the present study was higher than rates in several multicenter prospective cohort studies&#44; which ranged from 30&#46;7-42&#37; <a class="elsevierStyleCrossRef" href="#bib5">5</a>&#44;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#44;<a class="elsevierStyleCrossRef" href="#bib10">10</a>&#44;<a class="elsevierStyleCrossRef" href="#bib11">11</a>&#44;<a class="elsevierStyleCrossRef" href="#bib14">14</a>&#44;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#44;<a class="elsevierStyleCrossRef" href="#bib19">19</a>&#46; In one Brazilian multicenter study by Azevedo et al&#46;&#44; the hospital mortality rate was 42&#37; <a class="elsevierStyleCrossRef" href="#bib15">15</a>&#46; When comparing the mortality rates in our study with those in the literature&#44; several aspects must be taken into account&#46; These aspects include different methodologies &#40;e&#46;g&#46;&#44; inclusion criteria&#44; characteristics of the population&#41; and different severities of illness&#46; Our study specifically showed that APACHE II score&#44; organ failures&#44; ALI&#47;ARDS&#44; sepsis and age were independently associated with hospital mortality&#46; Mortality risk factors have also been the focus of several investigations <a class="elsevierStyleCrossRef" href="#bib3">3</a>&#44;<a class="elsevierStyleCrossRef" href="#bib5">5</a>&#44;<a class="elsevierStyleCrossRef" href="#bib8">8</a>&#44;<a class="elsevierStyleCrossRef" href="#bib10">10</a>&#44;<a class="elsevierStyleCrossRef" href="#bib11">11</a>&#44;&#46; The high severity of illness in our cohort may have contributed to the elevated mortality rates&#46; In this study&#44; the mean APACHE II score was higher when compared with scores in other studies <a class="elsevierStyleCrossRef" href="#bib5">5</a>&#44;<a class="elsevierStyleCrossRef" href="#bib14">14</a>&#46; Studies have also evaluated the severity of illness using the SAPS II score&#44; which is difficult to compare across studies <a class="elsevierStyleCrossRef" href="#bib10">10</a>&#44;<a class="elsevierStyleCrossRef" href="#bib11">11</a>&#44;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#46; Further evidence that our population had more severe illness was the higher percentage of patients with failure of three or more organs &#40;45&#37;&#41; compared with the percentage in another study&#44; in which 13&#37; of the patients had this condition <a class="elsevierStyleCrossRef" href="#bib13">13</a>&#46; Other reasons for higher mortality in our study were the reasons for initiation of MV&#44; which included sepsis &#40;41&#46;8&#37;&#41;&#44; shock &#40;37&#46;8&#37;&#41;&#44; pneumonia &#40;37&#37;&#41; and ALI&#47;ARDS &#40;15&#37;&#41;&#46; Azevedo et al&#46; showed that the main causes included pneumonia &#40;27&#37;&#41;&#44; neurological failure &#40;19&#37;&#41; and non-pulmonary sepsis &#40;12&#37;&#41; <a class="elsevierStyleCrossRef" href="#bib15">15</a>&#46; In addition&#44; Esteban et al&#46; reported different percentages for the main causes of MV&#44; such as postoperative patients <a class="elsevierStyleCrossRef" href="#bib10">10</a>&#46; Taken together&#44; these disparities probably resulted in a less severely ill population with lower mortality rates <a class="elsevierStyleCrossRef" href="#bib10">10</a>&#44;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#46;</p><p id="para220" class="elsevierStylePara elsevierViewall">The mortality of ARDS patients observed in our study was high&#46; One reason for this high mortality rate in ARDS patients was the severity of illness&#44; with a mean APACHE II score of 23&#46;6&#46; Furthermore&#44; 42&#46;5&#37; of ARDS patients had failure of three or more organs&#46; Additionally&#44; in ARDS patients&#44; the tidal volumes were higher than those suggested in the context of a lung-protective strategy&#44; which reduces mortality in these patients <a class="elsevierStyleCrossRef" href="#bib20">20</a>&#46; During the period of our study&#44; a lung-protective strategy was not completely incorporated into our practice&#44; which also could have affected the mortality rate&#46; Another reason for discrepancy could be that in our study&#44; we used a previously established criterion for the classification of ALI&#47;ARDS <a class="elsevierStyleCrossRef" href="#bib17">17</a>&#44; whereas mortality rates in other studies may have been influenced by the recent new Berlin definition of this syndrome <a class="elsevierStyleCrossRef" href="#bib21">21</a>&#46; In Brazil in particular&#44; using the Berlin definition&#44; Azevedo et al&#46; reported a hospital mortality rate of 52&#37; <a class="elsevierStyleCrossRef" href="#bib15">15</a>&#46; A systematic review found that ARDS mortality has remained static&#44; at 44&#37;&#44; for observational studies since the 1994 consensus definition of this syndrome <a class="elsevierStyleCrossRef" href="#bib22">22</a>&#44;<a class="elsevierStyleCrossRef" href="#bib23">23</a>&#46; For example&#44; in the ALIEN study&#44; the hospital mortality rate was 47&#46;8&#37; <a class="elsevierStyleCrossRef" href="#bib24">24</a>&#46; In the setting of low-to-middle countries&#44; best-practices strategies should be employed to reduce the mortality rates in ARDS patients&#46;</p><p id="para230" class="elsevierStylePara elsevierViewall">Our finding that age was independently associated with mortality in MV patients has also been described in previous studies <a class="elsevierStyleCrossRef" href="#bib8">8</a>&#46; In our study&#44; COPD and pneumonia as causes of MV&#44; in addition to VAP&#44; were found to be negatively associated with mortality in these patients&#46; COPD was also found to be protective by Esteban et al&#46; <a class="elsevierStyleCrossRef" href="#bib10">10</a>&#46; One possible explanation for the negative association of COPD and hospital mortality in the present study may be that such patients were less severely ill than those without COPD were&#59; these patients presented fewer morbidities during the MV period &#40;nonrespiratory system dysfunction&#41;&#46; It should be noted that few patients had COPD exacerbation as a cause of MV and admission to the ICU in this study&#46; Pneumonia as a cause of MV was also found to be negatively related to mortality&#44; which may have been due to a lower percentage of failure of three or more organs in this group of patients&#46; In two studies that examined risk factors for needing ventilatory support&#44; pneumonia was not associated with mortality after the multivariate analysis <a class="elsevierStyleCrossRef" href="#bib6">6</a>&#44;<a class="elsevierStyleCrossRef" href="#bib10">10</a>&#46; Studies of fatality rates comparing patients with and without VAP have generated contradictory results as to whether this condition increases mortality <a class="elsevierStyleCrossRef" href="#bib10">10</a>&#44;&#46; It should be noted that the present study was not designed to examine only VAP patients&#44; but rather included a myriad of patients requiring MV&#46; In addition&#44; according to our analysis&#44; VAP patients had a lower percentage of organ failure and of sepsis as a cause of MV compared with patients without VAP&#46;</p><p id="para240" class="elsevierStylePara elsevierViewall">Our study showed a lower frequency of NIMV compared with IMV&#46; Only 2&#46;3&#37; of patients remained on NIMV during the entire course of MV&#44; which could be explained by our overwhelming patient demand for the ICU&#59; in fact&#44; many patients who needed NIMV remained in the emergency department or in the hospital ward&#46; Our percentage of NIMV use was lower compared with percentages in other studies <a class="elsevierStyleCrossRef" href="#bib15">15</a>&#44;<a class="elsevierStyleCrossRef" href="#bib19">19</a>&#44;<a class="elsevierStyleCrossRef" href="#bib28">28</a>&#44;<a class="elsevierStyleCrossRef" href="#bib29">29</a>&#46; For example&#44; a recent Brazilian study had higher percentage of NIMV patients&#44; which could have led to different outcomes <a class="elsevierStyleCrossRef" href="#bib15">15</a>&#46; Additionally&#44; the percentage of NIMV failure was higher in our study than in recent investigations <a class="elsevierStyleCrossRef" href="#bib15">15</a>&#44;<a class="elsevierStyleCrossRef" href="#bib19">19</a>&#44;<a class="elsevierStyleCrossRef" href="#bib29">29</a>&#44; which may have been related to the difference in the severity of illness of the patients between the studies&#46; More specifically&#44; there was an important difference in the main reasons for the use of NIMV&#46; Our study also found a higher percentage of patients with pneumonia&#44; sepsis and ALI&#47;ARDS and a small number of patients with a greater demonstrated benefit regarding COPD exacerbation and acute pulmonary edema <a class="elsevierStyleCrossRef" href="#bib29">29</a><a class="elsevierStyleCrossRef" href="#bib30">30</a><a class="elsevierStyleCrossRef" href="#bib31">31</a>&#46;</p><p id="para250" class="elsevierStylePara elsevierViewall">The percentage of weaning failure in the present study was higher &#40;29&#46;4&#37;&#41; compared with percentages in the literature &#40;5-20&#37;&#41; <a class="elsevierStyleCrossRef" href="#bib15">15</a>&#44;<a class="elsevierStyleCrossRef" href="#bib32">32</a>&#46; Possible reasons may be related to &#40;i&#41; the fact that certain patients at high risk of weaning failure could not have used NIMV immediately after extubation and &#40;ii&#41; the lack of a weaning protocol&#46; Although recognizing that a protocol would not necessarily be crucial&#44; we think that it could have helped&#44; considering that our ICU is a multidisciplinary unit with a heterogeneous patient population&#46; Within the last few years&#44; we have been using a weaning protocol including NIMV in high-risk patients&#44; sharper surveillance regarding sedation&#44; and physiotherapist participation in patients&#39; weaning process&#46; Indeed&#44; recent data have shown that our percentage of weaning failure has dropped to 21&#37; <a class="elsevierStyleCrossRef" href="#bib32">32</a>&#46;</p><p id="para260" class="elsevierStylePara elsevierViewall">The limitations of our study include that &#40;i&#41; the data were obtained from one ICU&#44; so the results may not be generalizable to other patients who require MV&#59; &#40;ii&#41; the ICU was at a tertiary university hospital that admits patients with more severe illness&#47;conditions&#44; so the interpretation of the results may be different from that in other studies whose patients did not have similar disease severity&#59; and &#40;iii&#41; comorbidities&#44; such as neoplasia&#44; AIDS&#44; cirrhosis&#44; and chronic renal failure&#44; were not studied&#44; so the influence of such conditions on the mortality rates of the studied population could not be estimated&#46; Taking into account these limitations&#44; to the best of our knowledge&#44; this large study best describes the factors associated with mortality in ICU patients who required MV&#46;</p><p id="para270" class="elsevierStylePara elsevierViewall">The hospital mortality rate of MV patients in our study was higher than rates reported in the literature&#44; which may have been related to the severity of illness of the studied population&#46; Furthermore&#44; the factors associated with increased mortality included conditions present at the beginning of MV as well as conditions that occurred during mechanical support&#46; The epidemiological aspects of MV patients explored in our investigation could enhance knowledge of such patients in South America&#46; To the best of our knowledge&#44; this large cohort study of MV patients on this continent may contribute to a more global understanding regarding the use of MV&#46; In developing countries such as Brazil in particular&#44; the limited availability of ICU beds results in the admission of patients with more severe illness&#44; which may account for the higher mortality rates&#46; These observations should be considered when comparing the mortality of such patients among countries under diverse socioeconomic conditions&#46;</p></span><span id="cesec120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle170">AUTHOR CONTRIBUTIONS</span><p id="para280" class="elsevierStylePara elsevierViewall">Fialkow L designed the study&#44; participated in the acquisition of the data&#44; performed the statistical analyses of the data and wrote the manuscript&#46; Farenzena M designed the study and participated in the acquisition of the data&#46; Wawrzeniak IC conceived the study&#44; analyzed and interpreted the data and wrote the manuscript&#46; Brauner JS supervised the project&#44; participated in the acquisition of the data&#44; conceived the study&#44; and analyzed and interpreted the data&#46; Vieira SR supervised the project&#44; conceived the study&#44; participated in the acquisition of the data&#44; and analyzed and interpreted the data&#46; Vigo A performed the statistical analyses of the data&#46; Bozzetti MC performed the statistical analyses of the data and wrote the manuscript&#46; All authors contributed extensively to the work presented in this manuscript and took responsibility for reading and checking the text before submission&#46;</p></span></span>"
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                  "titulo" => "Independent variables"
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          "titulo" => "RESULTS"
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        4 => array:2 [
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          "titulo" => "DISCUSSION"
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          "titulo" => "AUTHOR CONTRIBUTIONS"
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          "identificador" => "xack638321"
          "titulo" => "ACKNOWLEDGMENTS"
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          "titulo" => "REFERENCES"
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    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2015-09-26"
    "fechaAceptado" => "2016-01-21"
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          "clase" => "keyword"
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          "palabras" => array:5 [
            0 => "Acute Respiratory Failure"
            1 => "Mechanical Ventilation"
            2 => "Mortality"
            3 => "Risk Factors"
            4 => "Epidemiology"
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        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVES&#58;</span><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">To determine the characteristics&#44; the frequency and the mortality rates of patients needing mechanical ventilation and to identify the risk factors associated with mortality in the intensive care unit &#40;ICU&#41; of a general university hospital in southern Brazil&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHOD&#58;</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">Prospective cohort study in patients admitted to the ICU who needed mechanical ventilation for at least 24 hours between March 2004 and April 2007&#46;</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS&#58;</span><p id="spara90" class="elsevierStyleSimplePara elsevierViewall">A total of 1&#44;115 patients admitted to the ICU needed mechanical ventilation&#46; The mortality rate was 51&#37;&#46; The mean age &#40;&#177; standard deviation&#41; was 57&#177;18 years&#44; and the mean Acute Physiology and Chronic Health Evaluation II &#40;APACHE II&#41; score was 22&#46;6&#177;8&#46;3&#46; The variables independently associated with mortality were &#40;i&#41; conditions present at the beginning of mechanical ventilation&#44; age &#40;hazard ratio&#58; 1&#46;01&#59; <span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&#59; the APACHE II score &#40;hazard ratio&#58; 1&#46;01&#59; <span class="elsevierStyleItalic">p</span>&#60;0&#46;005&#41;&#59; acute lung injury&#47;acute respiratory distress syndrome &#40;hazard ratio&#58; 1&#46;38&#59; <span class="elsevierStyleItalic">p</span>&#61;0&#46;009&#41;&#44; sepsis &#40;hazard ratio&#58; 1&#46;33&#59; <span class="elsevierStyleItalic">p</span>&#61;0&#46;003&#41;&#44; chronic obstructive pulmonary disease &#40;hazard ratio&#58; 0&#46;58&#59; <span class="elsevierStyleItalic">p</span>&#61;0&#46;042&#41;&#44; and pneumonia &#40;hazard ratio&#58; 0&#46;78&#59; <span class="elsevierStyleItalic">p</span>&#61;0&#46;013&#41; as causes of mechanical ventilation&#59; and renal &#40;hazard ratio&#58; 1&#46;29&#59; <span class="elsevierStyleItalic">p</span>&#61;0&#46;011&#41; and neurological &#40;hazard ratio&#58; 1&#46;25&#59; p&#61;0&#46;024&#41; failure&#44; and &#40;ii&#41; conditions occurring during the course of mechanical ventilation&#44; acute lung injuri&#47;acute respiratory distress syndrome &#40;hazard ratio&#58; 1&#46;31&#59; <span class="elsevierStyleItalic">p</span>&#60;0&#46;010&#41;&#59; sepsis &#40;hazard ratio&#58; 1&#46;53&#59; <span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&#59; and renal &#40;hazard ratio&#58; 1&#46;75&#59; <span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&#44; cardiovascular &#40;hazard ratio&#58; 1&#46;32&#59; <span class="elsevierStyleItalic">p</span>&#8804;0&#46;009&#41;&#44; and hepatic &#40;hazard ratio&#58; 1&#46;67&#59; <span class="elsevierStyleItalic">p</span>&#8804;0&#46;001&#41; failure&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSIONS&#58;</span><p id="spara100" class="elsevierStyleSimplePara elsevierViewall">This large cohort study provides a comprehensive profile of mechanical ventilation patients in South America&#46; The mortality rate of patients who required mechanical ventilation was higher&#44; which may have been related to the severity of illness of the patients admitted to our ICU&#46; Risk factors for hospital mortality included conditions present at the start of mechanical ventilation conditions that occurred during mechanical support&#46;</p></span>"
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            "titulo" => "OBJECTIVES&#58;"
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            "titulo" => "METHOD&#58;"
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            "titulo" => "RESULTS&#58;"
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            "titulo" => "CONCLUSIONS&#58;"
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        "nota" => "<p class="elsevierStyleNotepara" id="cenpara90">No potential conflict of interest was reported&#46;</p>"
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          "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Figure 1&#46;</span> Kaplan-Meier curves of the probability of survival over time for mechanical ventilation&#46;</p>"
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          "leyenda" => "<p id="tfn1" class="elsevierStyleSimplePara elsevierViewall">APACHE II &#61; Acute Physiology and Chronic Health Evaluation II&#59; ALI &#61; acute lung injury&#59; ARDS &#61; acute respiratory distress syndrome&#59; COPD &#61; chronic obstructive pulmonary disease&#59; SD &#61; standard deviation&#59; <span class="elsevierStyleSup">1</span> more than one reason for initiation of mechanical ventilation was allowed&#46;</p>"
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                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="middle" scope="col">Characteristic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">Number of Patients Mechanically Ventilated&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Age&#44; median&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">57&#46;2&#177;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Gender&#44; males&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">582 &#40;52&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">APACHE II score&#44; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">22&#46;6&#177;8&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">771 &#40;69&#37;&#41;&#47;344 &#40;31&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Source of admission&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hospital ward&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">625 &#40;56&#37;&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Emergency department&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">278 &#40;25&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Other hospitals&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">212 &#40;19&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Reason for the initiation of mechanical ventilation<span class="elsevierStyleSup">1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sepsis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">466 &#40;41&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Shock&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">421 &#40;37&#46;8&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pneumonia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">415 &#40;37&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ALI&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">167 &#40;15&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ALI without ARDS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">40 &#40;3&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ARDS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">127 &#40;11&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Neurological condition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Stroke&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">79 &#40;7&#46;1&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Neuromuscular disease&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">15 &#40;1&#46;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Other neurological condition&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">32 &#40;3&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>COPD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">60 &#40;5&#46;4&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Cardiac arrest&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">67 &#40;6&#46;0&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Asthma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">16 &#40;1&#46;6&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Other&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">14 &#40;1&#46;2&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Characteristics of the Studied Patients on Admission to the Intensive Care Unit&#46;</p>"
        ]
      ]
      2 => array:7 [
        "identificador" => "tbl2"
        "etiqueta" => "Table 2"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:2 [
          "leyenda" => "<p id="tfn2" class="elsevierStyleSimplePara elsevierViewall">COPD &#61; chronic obstructive pulmonary disease&#59; ARDS &#61; acute respiratory distress syndrome&#59; ACP &#61; assisted&#47;controlled pressure ventilation&#59; ACV &#61; assisted&#47;controlled volume ventilation&#59; PSV &#61; pressure support ventilation&#59; CPAP &#61; continuous positive airway pressure&#59; SIMV &#61; synchronized intermittent mandatory ventilation&#59; PBW &#61; predicted body weight&#59; PEEP &#61; positive end-expiratory pressure&#59; SD &#61; standard deviation&#59; <span class="elsevierStyleSup">1</span> the percentages of missing data for all patients and for the COPD and ARDS groups in particular were 12&#37;&#44; 11&#37;&#44; and 14&#37;&#44; respectively&#59; <span class="elsevierStyleSup">2</span> refers to non-COPD and non-ARDS patients&#46;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="middle" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">Overall &#40;n&#61;976&#41;<span class="elsevierStyleSup">1</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">COPD &#40;n&#61;56&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">ARDS &#40;n&#61;263&#41;<span class="elsevierStyleSup">a</span>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Ventilator mode&#44; no&#46; &#40;&#37;&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ACP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">715 &#40;73&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">37 &#40;66&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">200 &#40;76&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PSV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">195 &#40;20&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">14 &#40;25&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">46 &#40;17&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CPAP&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">29 &#40;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">3 &#40;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">9 &#40;3&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ACV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">22 &#40;2&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">2 &#40;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">7 &#40;2&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>SIMV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">15 &#40;1&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">0 &#40;0&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">7 &#40;2&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Monitored variable&#44; mean&#177;SD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Peak pressure&#44; cm H<span class="elsevierStyleInf">2</span>O&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">25&#46;5&#177;8&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">24&#177;4&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">28&#46;5&#177;8&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Plateau pressure&#44; cm H<span class="elsevierStyleInf">2</span>O&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">21&#46;5&#177;5&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">20&#46;2&#177;4&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">23&#46;6&#177;6&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Tidal volume&#44; ml&#47;kg &#40;PBW&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">10&#46;5&#177;3&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">10&#177;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">9&#177;3&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Respiratory rate&#44; breaths&#47;min&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">20&#46;1&#177;4&#46;1&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">19&#46;3&#177;3&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">21&#46;2&#177;4&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PaO<span class="elsevierStyleInf">2</span>&#47;FiO<span class="elsevierStyleInf">2</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">298&#46;8&#177;155&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">292&#46;4&#177;118&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">169&#177;111&#46;3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>PEEP&#44; cm H<span class="elsevierStyleInf">2</span>O&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">6&#46;6&#177;2&#46;5&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">5&#46;8&#177;1&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="top">9&#177;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Ventilator Modes and Monitored Variables on Days 1&#44; 2 and 3 &#40;Mean Values&#41; of Invasive Mechanical Ventilation&#46;</p>"
        ]
      ]
      3 => array:7 [
        "identificador" => "tbl3"
        "etiqueta" => "Table 3"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="tfn3" class="elsevierStyleSimplePara elsevierViewall">MV &#61; mechanical ventilation&#59; LOS &#61; length of stay&#59; COPD &#61; chronic obstructive pulmonary disease&#59; ARDS &#61; acute respiratory distress syndrome&#59;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="middle" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">Other Patients<a class="elsevierStyleCrossRef" href="#tfn5">2</a> &#40;n&#61;748&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">COPD &#40;n&#61;60&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col">ARDS &#40;n&#61;307&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="middle" scope="col"><span class="elsevierStyleItalic">p</span>-value<a class="elsevierStyleCrossRef" href="#tfn6">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Duration of MV<a class="elsevierStyleCrossRef" href="#tfn4">1</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">9&#46;3&#177;7&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">8&#46;9&#177;5&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">12&#46;1&#177;8&#46;7&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&#60;0&#46;01<a class="elsevierStyleCrossRef" href="#tfn7">&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">LOS in ICU<a class="elsevierStyleCrossRef" href="#tfn4">1</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">14&#46;6&#177;11&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">14&#46;3&#177;10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">LOS in hospital<a class="elsevierStyleCrossRef" href="#tfn4">1</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="char" valign="top">22&#46;3&#177;21&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:4 [
            0 => array:3 [
              "identificador" => "tfn4"
              "etiqueta" => "1"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">days&#59;</p>"
            ]
            1 => array:3 [
              "identificador" => "tfn5"
              "etiqueta" => "2"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara20">refers to non-COPD and non-ARDS patients&#59;</p>"
            ]
            2 => array:3 [
              "identificador" => "tfn6"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara30"><span class="elsevierStyleItalic">p</span>-value for ANOVA&#59;</p>"
            ]
            3 => array:3 [
              "identificador" => "tfn7"
              "etiqueta" => "&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara40"><span class="elsevierStyleItalic">p</span>&#60;0&#46;001 for ANOVA &#40;and <span class="elsevierStyleItalic">p</span>&#60;0&#46;05 for the Tukey test for the following comparisons&#58; COPD <span class="elsevierStyleItalic">vs</span>&#46; ARDS patients and other patients <span class="elsevierStyleItalic">vs</span>&#46; ARDS patients&#41;&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Duration of Mechanical Ventilation and Length of Stay in the Intensive Care Unit and in the Hospital in the Studied Patients&#46;</p>"
        ]
      ]
      4 => array:7 [
        "identificador" => "tbl4"
        "etiqueta" => "Table 4"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="tfn8" class="elsevierStyleSimplePara elsevierViewall">APACHE II &#61; Acute Physiology and Chronic Health Evaluation II&#59; ARF &#61; acute respiratory failure&#59; HR &#61; hazard ratio&#59; CI &#61; confidence interval&#59;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
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                  \t\t\t\t  " align="center" valign="middle" scope="col">Group&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="middle" scope="col">n&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="middle" scope="col">Age<a class="elsevierStyleCrossRef" href="#tfn9">&#42;</a>&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="center" valign="middle" scope="col">APACHE II Score<a class="elsevierStyleCrossRef" href="#tfn9">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
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                  \t\t\t\t  " align="center" valign="middle" scope="col">Hospital Mortality &#40;&#37;&#41;<a class="elsevierStyleCrossRef" href="#tfn10">&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
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                  \t\t\t\t  " align="center" valign="middle" scope="col">HR &#40;95&#37; CI&#41;<a class="elsevierStyleCrossRef" href="#tfn10">&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="top">ARF&#43;0&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top">138&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top">57&#46;5&#177;17&#46;8&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">19&#46;0&#177;7&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="center" valign="top">21&#46;0&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="center" valign="top">1&#46;0&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top">248&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top">57&#46;1&#177;19&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top">19&#46;9&#177;7&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="center" valign="top">37&#46;1&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;91 &#40;1&#46;26-2&#46;89&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">ARF&#43;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top">285&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top">58&#46;7&#177;17&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top">22&#46;7&#177;7&#46;6&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">3&#46;35 &#40;2&#46;26-4&#46;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">ARF&#43;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top">249&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top">58&#46;5&#177;17&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">24&#46;9&#177;8&#46;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="center" valign="top">64&#46;7&#37;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">ARF&#43;4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">139&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="top">54&#46;0&#177;17&#46;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">26&#46;6&#177;9&#46;2&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">69&#46;8&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">4&#46;62 &#40;3&#46;05-6&#46;99&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">ARF&#43;5&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">52&#46;4&#177;19&#46;9&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">25&#46;3&#177;7&#46;3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">73&#46;2&#37;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">5&#46;24 &#40;3&#46;25-8&#46;43&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "tfn9"
              "etiqueta" => "&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara50">mean&#177;standard deviation&#59;</p>"
            ]
            1 => array:3 [
              "identificador" => "tfn10"
              "etiqueta" => "&#42;&#42;"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara60"><span class="elsevierStyleItalic">p</span>-value for linear trend&#58; hospital mortality &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41; and HR &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall">Severity of Illness and Hospital Mortality According to the Number of Organs with Failure&#46;</p>"
        ]
      ]
      5 => array:7 [
        "identificador" => "tbl5"
        "etiqueta" => "Table 5"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
        "mostrarDisplay" => false
        "tabla" => array:3 [
          "leyenda" => "<p id="tfn11" class="elsevierStyleSimplePara elsevierViewall">ALI&#47;ARDS &#61; acute lung injury&#47;acute respiratory distress syndrome&#59; APACHE II &#61; Acute Physiology and Chronic Health Evaluation II&#59; COPD &#61; chronic obstructive pulmonary disease&#59; MV &#61; mechanical ventilation&#59; VAP&#61; ventilator-associated pneumonia&#59;</p>"
          "tablatextoimagen" => array:1 [
            0 => array:1 [
              "tabla" => array:1 [
                0 => """
                  <table border="0" frame="\n
                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">Variable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Univariable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Multivariable&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="left" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">HR &#40;95&#37; CI&#41;<a class="elsevierStyleCrossRef" href="#tfn12">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p</span>-value<a class="elsevierStyleCrossRef" href="#tfn13">&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">HR &#40;95&#37; CI&#41;<a class="elsevierStyleCrossRef" href="#tfn12">&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p</span>-value<a class="elsevierStyleCrossRef" href="#tfn13">&#42;&#42;</a>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;07 &#40;1&#46;002-1&#46;012&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;01 &#40;1&#46;004-1&#46;014&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">&#60;0&#46;001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">APACHE II score&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;01 &#40;1&#46;007-1&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;01 &#40;1&#46;002-1&#46;014&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">&#60;0&#46;005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Chronic use of corticosteroids&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;72 &#40;0&#46;53-0&#46;97&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Failure previous to MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Cardiovascular&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;42 &#40;1&#46;20-1&#46;67&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Coagulopathic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;46 &#40;1&#46;21-1&#46;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Hepatic&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;26 &#40;1&#46;02-1&#46;57&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Renal&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;34 &#40;1&#46;14-1&#46;59&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;29 &#40;1&#46;06-1&#46;56&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;011&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Neurological&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;13 &#40;0&#46;94-1&#46;35&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;25 &#40;1&#46;031&#46;52&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;024&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Cause of MV initiation&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>COPD&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;42 &#40;0&#46;25-0&#46;69&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;0006&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;58 &#40;0&#46;35-0&#46;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;042&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>ALI&#47;ARDS&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;33 &#40;1&#46;08-1&#46;65&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;008&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;38 &#40;1&#46;08-1&#46;77&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Sepsis&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;47 &#40;1&#46;25-1&#46;73&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">&#60;0&#46;0001&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">1&#46;33 &#40;1&#46;10-1&#46;61&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Pneumonia&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;88 &#40;0&#46;74-1&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;78 &#40;0&#46;65-0&#46;95&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;013&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>Asthma&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;43 &#40;0&#46;16-1&#46;15&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="top">0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">Condition occurring during MV&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="top">&nbsp;\t\t\t\t\t\t\n
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Article information

ISSN: 18075932
Original language: English

DOI:10.6061/clinics/2016(03)05

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Year/Month	Html	Pdf	Total

2024 November	10	2	12
2024 October	27	24	51
2024 September	28	15	43
2024 August	43	34	77
2024 July	49	31	80
2024 June	29	13	42
2024 May	34	16	50
2024 April	48	18	66
2024 March	43	26	69
2024 February	51	20	71
2024 January	84	32	116
2023 December	61	32	93
2023 November	34	18	52
2023 October	51	24	75
2023 September	38	18	56
2023 August	30	5	35
2023 July	21	11	32
2023 June	12	4	16
2023 May	15	5	20
2023 April	14	5	19
2023 March	16	4	20
2023 February	7	1	8
2023 January	13	0	13
2022 December	18	2	20
2022 November	5	0	5

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