CLINICAL SCIENCE
Association of CYP1A1 A4889G and T6235C polymorphisms with the risk of sporadic breast cancer in Brazilian women
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=> array:4 [ "autoresLista" => "Camila Borges Martins de Oliveira, Cássio Cardoso-Filho, Leonardo Silveira Bossi, Gustavo Jacob Lourenço, Maria Salete Costa-Gurgel, Carmen Silvia Passos Lima" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Camila Borges Martins" "apellidos" => "de Oliveira" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Cássio" "apellidos" => "Cardoso-Filho" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">II</span>" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "Leonardo Silveira" "apellidos" => "Bossi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">II</span>" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Gustavo Jacob" "apellidos" => "Lourenço" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] ] ] 4 => array:3 [ "nombre" => "Maria Salete" "apellidos" => "Costa-Gurgel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">II</span>" "identificador" => "aff2" ] ] ] 5 => array:4 [ "nombre" => "Carmen Silvia Passos" "apellidos" => "Lima" "email" => array:1 [ 0 => "carmenl@fcm.unicamp.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Universidade de Campinas, Faculdade de Ciências Médicas, Departamento de Clínica Médica, Campinas, SP, Brazil" "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Universidade de Campinas, Centro de Assistência Integral à Saúde da Mulher, Campinas, SP, Brazil" "etiqueta" => "II" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Corresponding author:" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">High-penetrance mutations account for a small proportion of breast cancer (BC) cases <a class="elsevierStyleCrossRef" href="#bib1">1</a> and several epidemiological studies have indicated the involvement of low-penetrance genetic polymorphisms in the pathophysiology of BC <a class="elsevierStyleCrossRef" href="#bib2">2</a>. In addition to these genetic factors, compelling evidence supports the role of systemic hypertension, tobacco, obesity and exposure to polycyclic aromatic hydrocarbons (PAHs) in BC formation through the promotion of DNA damage and cell proliferation <a class="elsevierStyleCrossRefs" href="#bib3">3–6</a>. Prolonged estrogen exposure is also widely accepted as a risk factor for BC due to its mitotic activity and increased mutation rates <a class="elsevierStyleCrossRef" href="#bib7">7</a> and catechol estrogens can be carcinogen metabolites <a class="elsevierStyleCrossRef" href="#bib8">8</a>,<a class="elsevierStyleCrossRef" href="#bib9">9</a>. Hence, some reproductive events, such as age at menarche, first-full term pregnancy (FFTP) and menopause, may play important roles in BC risk <a class="elsevierStyleCrossRef" href="#bib10">10</a>,<a class="elsevierStyleCrossRef" href="#bib11">11</a>. Carriers of low-penetrance gene mutations, combined with the above-mentioned factors, might have a higher tumor risk <a class="elsevierStyleCrossRef" href="#bib12">12</a>,<a class="elsevierStyleCrossRef" href="#bib13">13</a>.</p><p id="para20" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">CYP1A1</span> gene <a class="elsevierStyleCrossRef" href="#bib14">14</a> encodes the P450-1A1 (CYP1A1) enzyme, which has aryl hydrocarbon hydroxylase activity. This enzyme converts PAHs to aryl epoxides carcinogens. The enzyme also participates in estrogen metabolism by catalyzing the 2-hydroxylation of estradiol, which results in free radical and DNA adduct production <a class="elsevierStyleCrossRef" href="#bib15">15</a>. Two polymorphisms in this gene have been studied in relation to BC: an A4889G substitution in exon 7 (rs1048943) and a T6235C substitution in the 3′ untranslated region (rs4646903) <a class="elsevierStyleCrossRef" href="#bib16">16</a>. G and C allele variants yield enzymes with increased activities in PAHs activation <a class="elsevierStyleCrossRef" href="#bib17">17</a> and estrogen metabolism <a class="elsevierStyleCrossRef" href="#bib18">18</a>. However, the role of these variants in BC risk in individuals from the United States of America, Europe and Asia is still controversial. Some studies have reported that G and C allele variants increase BC risk <a class="elsevierStyleCrossRef" href="#bib5">5</a>, while other studies have not observed main effects for <span class="elsevierStyleItalic">CYP1A1</span> variants <a class="elsevierStyleCrossRef" href="#bib3">3</a>,<a class="elsevierStyleCrossRef" href="#bib5">5</a>,<a class="elsevierStyleCrossRefs" href="#bib19">19–22</a>,<a class="elsevierStyleCrossRef" href="#bib25">25</a>,. Regarding the clinical features and biological characteristics of tumors, the impact of these genetic polymorphisms varies <a class="elsevierStyleCrossRef" href="#bib3">3</a>,<a class="elsevierStyleCrossRef" href="#bib5">5</a>,<a class="elsevierStyleCrossRef" href="#bib10">10</a>,<a class="elsevierStyleCrossRef" href="#bib12">12</a>,<a class="elsevierStyleCrossRef" href="#bib15">15</a>,<a class="elsevierStyleCrossRefs" href="#bib19">19–23</a>,<a class="elsevierStyleCrossRef" href="#bib20">27</a>,. These contradictory findings might be explained by the ethnic variations among populations and small study sample sizes <a class="elsevierStyleCrossRef" href="#bib41">41</a>.</p><p id="para30" class="elsevierStylePara elsevierViewall">The Brazilian population is highly heterogeneous and consists of indigenous Amerindians and immigrants from Europe, Asia and Africa <a class="elsevierStyleCrossRef" href="#bib42">42</a>. Cancer is the second most common cause of death in the southeastern region of Brazil and BC represents the most common cause of tumor death among women <a class="elsevierStyleCrossRef" href="#bib43">43</a>. To the best of our knowledge, the role of <span class="elsevierStyleItalic">CYP1A1</span> A4889G and T6235C polymorphisms in the risk, clinical features and biological characteristics of BC tumors is unknown for people living in the Southern hemisphere. Because large numbers of participants are needed worldwide to examine the associations between a genetic polymorphism and cancer risk, we analyzed the frequencies of the <span class="elsevierStyleItalic">CYP1A1</span> A4889G and T6235C genotypes in large samples of BC patients and controls from the southeastern region of Brazil. We also investigated whether these genotypes influence the risk of BC tumors in Brazil.</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">MATERIALS AND METHODS</span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">Study population</span><p id="para40" class="elsevierStylePara elsevierViewall">We analyzed 742 consecutive female patients with sporadic breast cancer (SBC) at diagnosis (median age, 53 years; range, 22–91 years; 638 Caucasians and 104 non-Caucasians). The patients were treated at the <span class="elsevierStyleUnderline">Center of Integral Attention to Women's Health of the University of Campinas</span>, Campinas/SP, Brazil, from March 2004 to March 2007. The clinical features were determined from a questionnaire, including age at diagnosis, ethnic origin, age at menarche, age at FFTP and age at menopause, lactation status, smoking habits, oral contraceptives use and presence or absence of systemic hypertension. The patients were considered to be smokers if they kept smoking until the moment of diagnosis and the patients were classified as non-smokers if they had never smoked. The body mass index (BMI) was calculated according to the World Health Organization classification and the patients were classified into four groups: underweight, normal, pre-obese and obese <a class="elsevierStyleCrossRef" href="#bib44">44</a>. BC was diagnosed through the histological evaluation of tumor biopsies. The nuclear and histological grades <a class="elsevierStyleCrossRef" href="#bib45">45</a> and tumor stages <a class="elsevierStyleCrossRef" href="#bib46">46</a> were established according to conventional criteria. The expression levels of estrogen and progesterone receptors were analyzed through immunohistochemistry using the streptavidin-biotin complex method <a class="elsevierStyleCrossRef" href="#bib47">47</a> with estrogen receptor-clone 6F11 and progesterone receptor-clone 6F16 antibodies (Novocastra Laboratories, Tyne and Wear, <span class="elsevierStyleUnderline">Newcastle, UK</span>).</p><p id="para50" class="elsevierStylePara elsevierViewall">The control group was composed of 742 healthy female blood donors (median age, 40 years; range, 18–65 years; 638 Caucasians and 104 non-Caucasians) from the Centro de Hematologia e Hemoterapia of the Universidade de Campinas (during the same study period). These patients were selected to represent the general population seeking medical assistance in our region. The control group patients were matched with the BC patients according to age and ethnicity. Patients and controls with evidence of a personal or family history of BC and patients who chose not to participate in the study were excluded from the analyses. All procedures were performed according to the Declaration of Helsinki and all subjects provided written informed consent. The study was approved by the local ethics committee (process number 581/2002).</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">Polymorphism analysis</span><p id="para60" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">CYP1A1</span> A4889G (rs1048943) and T6235C (rs4646903) genotypes were identified in genomic DNA from the peripheral blood samples of subjects using the polymerase chain reaction followed by restriction fragment length polymorphism, as previously reported <a class="elsevierStyleCrossRef" href="#bib48">48</a>.</p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">Statistical analyses</span><p id="para70" class="elsevierStylePara elsevierViewall">The Hardy-Weinberg (HW) equilibrium was tested using chi-squared (χ2) statistics for the goodness-of-fit (one degree of freedom). The pairwise linkage disequilibrium (LD) analysis was performed using Haploview 4.2 software (<a href="http://www.broad.mit.edu/mpg/haploview">www.broad.mit.edu/mpg/haploview</a>) to ensure that the markers were appropriate for inclusion in the haplotype estimates. The LD was measured using the disequilibrium coefficient (D′´) and strong LD significance was considered as D′´≥ 80%. Between-group differences were analyzed with χ<span class="elsevierStyleSup">2</span> or Fisher exact tests. A multivariate analysis using the logistic regression model was used to obtain the age and ethnic origin adjusted crude odds ratios (ORs) with 95% confidence intervals (CI) and to assess the associations between the genotypes and BC. A power of analysis (PA) was used to calculate the minimum effect size likely to be detected in a study using a given sample size, according to Pocock <a class="elsevierStyleCrossRef" href="#bib49">49</a> and Hulley et al. <a class="elsevierStyleCrossRef" href="#bib50">50</a> in analyses involving patients and controls and according to the DSS Research statistical power calculators <a class="elsevierStyleCrossRef" href="#bib51">51</a> when considering the patients stratified by clinical and tumor characteristics. The data analyses were performed with SPSS 15.0 software (SPSS Incorporation, Chicago, IL, USA). For all statistical tests, the level of significance was 2-sided at <span class="elsevierStyleItalic">p</span><0.05.</p></span></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">RESULTS</span><p id="para80" class="elsevierStylePara elsevierViewall">The patient and control samples were in HW equilibrium at the <span class="elsevierStyleItalic">CYP1A1</span> A4889G (χ<span class="elsevierStyleSup">2</span>=0.15, <span class="elsevierStyleItalic">p</span>=0.70; χ<span class="elsevierStyleSup">2</span>=1.15, <span class="elsevierStyleItalic">p</span>=0.28) and T6235C (χ<span class="elsevierStyleSup">2</span>=2.65, <span class="elsevierStyleItalic">p</span>=0.10; χ<span class="elsevierStyleSup">2</span>=1.93, <span class="elsevierStyleItalic">p</span>=0.16) loci, respectively. The LD analyses revealed a moderate LD between the A4889G and T6235C polymorphisms of <span class="elsevierStyleItalic">CYP1A1</span> (D′=73%), and the referred polymorphisms were considered for further analysis of the haplotypes.</p><p id="para90" class="elsevierStylePara elsevierViewall">More patients had the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG (PA=87.0%) and <span class="elsevierStyleItalic">CYP1A1</span> 4889AG+GG (PA=93.0%) genotypes compared with the controls. <span class="elsevierStyleUnderline">Compared with the other study participants, carriers of the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG genotype had a 1.45-fold increased risk of SBC and carriers of the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG+GG genotypes had a 1.50-fold increased risk.</span>Similar frequencies of the <span class="elsevierStyleItalic">CYP1A1</span> T6235C genotypes and <span class="elsevierStyleItalic">CYP1A1</span> haplotypes were observed in the patients and controls enrolled in the study (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>).</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><p id="para100" class="elsevierStylePara elsevierViewall">The <span class="elsevierStyleItalic">CYP1A1</span> 4889AG and 4889AG+GG genotypes were more common in the Caucasian SBC patients than in the non-Caucasian patients (PA=73.0% and PA=57.3%, respectively) and controls (27.9% <span class="elsevierStyleItalic">versus</span> 21.1%, <span class="elsevierStyleItalic">p</span>=0.002, PA=98% and 30.4% <span class="elsevierStyleItalic">versus</span> 23.2%, <span class="elsevierStyleItalic">p</span>=0.002, PA=98%, respectively). Caucasians with the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG and 4889AG+GG genotypes had a 1.61-fold and 1.61-fold increased risk of tumors, respectively, than Caucasians with the remaining genotypes, respectively. An excess of the <span class="elsevierStyleItalic">CYP1A1</span> 6235CC genotype was observed in SBC patients with a lower median age of menarche (younger than 13 years of age) compared to patients who experienced menarche at a higher median age (13 years of age and older, PA=55.3%). The <span class="elsevierStyleItalic">CYP1A1</span> 4889AG+GG genotype was more common among patients with a lower median age at FFTP (younger than 22 years of age) than among patients who experienced FFTP at a higher median age (22 years of age and older) PA=58.6%). The frequency of the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG+GG genotype was higher among patients with an earlier FFTP than among the controls (33.8% <span class="elsevierStyleItalic">versus</span> 23.2%, <span class="elsevierStyleItalic">p=</span>0.001, PA>99.0%). Women with the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG+GG genotype and FFTP occurring earlier in life had a 1.87-fold increased risk of SBC compared to subjects with the AA genotype. The frequency of the <span class="elsevierStyleItalic">CYP1A1</span> 6235CC genotype in pre-obese and obese patients was higher than in normal and underweight patients (PA=32.1%). Moreover, the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG (PA=77.1%), <span class="elsevierStyleItalic">CYP1A1</span> 4889AG+GG (PA=69.3%) and <span class="elsevierStyleItalic">CYP1A1</span> 6235TC+CC (PA=63.0%) genotypes were more common among patients with I and II histological grade tumors than among patients with grade III tumors. The frequencies of the respective genotypes in patients from the first group were also higher than those observed in the controls (37.6% <span class="elsevierStyleItalic">versus</span> 21.2%, <span class="elsevierStyleItalic">p</span><0.001, PA>99.0%; 39.8% <span class="elsevierStyleItalic">versus</span> 23.2%, <span class="elsevierStyleItalic">p<</span>0.001, PA>99.0%; 48.4% <span class="elsevierStyleItalic">versus</span> 38.6%, <span class="elsevierStyleItalic">p=</span>0.04, PA=95.0%). Individuals with the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG, <span class="elsevierStyleItalic">CYP1A1</span>AG+GG, and <span class="elsevierStyleItalic">CYP1A1</span> 6235TC+CC genotypes had 2.48-, 2.44- and 1.67-fold increased risks, respectively, for SBC compared to study participants with the remaining genotypes (<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>). Similar frequencies of the <span class="elsevierStyleItalic">CYP1A1</span> A4889G and T6235C genotypes were observed among patients stratified by age at diagnosis, age at menarche (younger than 12 years <span class="elsevierStyleItalic">versus</span> 12 years and older), age at menopause and FFTP (younger than 30 years <span class="elsevierStyleItalic">versus</span> 30 years and older), oral contraceptive use, lactation, cigarette smoking habit, systemic hypertension, tumor histology, stage and estrogen and progesterone receptor patterns. The frequencies of the <span class="elsevierStyleItalic">CYP1A1</span> haplotypes did not differ among patients stratified by clinical and tumor features (data not shown).</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">DISCUSSION</span><p id="para110" class="elsevierStylePara elsevierViewall">In this case-control study, we examined the influence of the <span class="elsevierStyleItalic">CYP1A1</span> A4889G and T6235C polymorphisms on the risk of SBC. We also investigated whether these polymorphisms are associated with the clinical features of SBC patients and with the biological tumor characteristics.</p><p id="para120" class="elsevierStylePara elsevierViewall">We initially found that the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG and 4889AG+GG genotypes were associated with a higher risk of BC in our cohort. Our results were consistent with the findings of Chacko et al. <a class="elsevierStyleCrossRef" href="#bib23">23</a>, Singh et al. <a class="elsevierStyleCrossRef" href="#bib36">36</a> and Surekha et al. <a class="elsevierStyleCrossRef" href="#bib27">27</a> (studies conducted in India). Ambrosone et al. <a class="elsevierStyleCrossRef" href="#bib19">19</a> and Ishibe et al. <a class="elsevierStyleCrossRef" href="#bib5">5</a> also reported an increased risk of BC among G variant allele carriers (with smoking habits) from the United States of America. In fact, cytochrome P450 enzymes encoded by the <span class="elsevierStyleItalic">CYP1A1</span> gene play an important role in the phase I bioactivation of xenobiotics and in the metabolism of estrogen (converting the metabolites into carcinogens) <a class="elsevierStyleCrossRef" href="#bib15">15</a>. G variant allele carriers of the <span class="elsevierStyleItalic">CYP1A1</span> A4889G polymorphism have a higher catalytic enzyme activity <a class="elsevierStyleCrossRef" href="#bib17">17</a>,<a class="elsevierStyleCrossRef" href="#bib18">18</a>, which results in a higher level of carcinogens in breast tissue and, consequently, a higher level of DNA adducts, which may serve as the initial step in BC development. In contrast with our study, the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG genotype was associated with a lower risk of BC among Japanese <a class="elsevierStyleCrossRef" href="#bib40">40</a> patients. Furthermore, no association between the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG polymorphism and BC risk was observed among North Americans <a class="elsevierStyleCrossRefs" href="#bib19">19–22</a>,<a class="elsevierStyleCrossRef" href="#bib30">30</a>,<a class="elsevierStyleCrossRef" href="#bib33">33</a>, Chinese <a class="elsevierStyleCrossRef" href="#bib21">21</a>,<a class="elsevierStyleCrossRef" href="#bib34">34</a>, Europeans <a class="elsevierStyleCrossRef" href="#bib31">31</a>, or Indians <a class="elsevierStyleCrossRef" href="#bib25">25</a>,<a class="elsevierStyleCrossRef" href="#bib28">28</a>. These discrepant results seem to be due to ethnic variations among the studied populations because the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG+GG genotype was both underrepresented <a class="elsevierStyleCrossRef" href="#bib21">21</a>,<a class="elsevierStyleCrossRef" href="#bib25">25</a>,<a class="elsevierStyleCrossRef" href="#bib28">28</a>,<a class="elsevierStyleCrossRef" href="#bib34">34</a>,<a class="elsevierStyleCrossRef" href="#bib40">40</a> and overrepresented <a class="elsevierStyleCrossRef" href="#bib19">19</a>,<a class="elsevierStyleCrossRef" href="#bib20">20</a>,<a class="elsevierStyleCrossRef" href="#bib22">22</a>,<a class="elsevierStyleCrossRef" href="#bib30">30</a>,<a class="elsevierStyleCrossRef" href="#bib31">31</a>,<a class="elsevierStyleCrossRef" href="#bib33">33</a>,<a class="elsevierStyleCrossRef" href="#bib35">35</a> in our controls compared with controls from the other studies.</p><p id="para130" class="elsevierStylePara elsevierViewall">In our study, the <span class="elsevierStyleItalic">CYP1A1</span> T6235C polymorphism was not associated with SBC risk. Although a large number of subjects were evaluated, the statistical analyses were characterized by a low statistical power. In addition, the <span class="elsevierStyleItalic">CYP1A1</span> T6235C polymorphism did not alter the risk of BC among African-Americans <a class="elsevierStyleCrossRef" href="#bib30">30</a>,<a class="elsevierStyleCrossRef" href="#bib33">33</a>, North-Americans <a class="elsevierStyleCrossRef" href="#bib5">5</a>,<a class="elsevierStyleCrossRef" href="#bib21">21</a>,<a class="elsevierStyleCrossRef" href="#bib30">30</a>,<a class="elsevierStyleCrossRef" href="#bib33">33</a>, Chinese <a class="elsevierStyleCrossRef" href="#bib34">34</a>, Indians <a class="elsevierStyleCrossRef" href="#bib25">25</a>,<a class="elsevierStyleCrossRef" href="#bib36">36</a>, or Brazilians <a class="elsevierStyleCrossRef" href="#bib37">37</a>. In contrast, Miyoshi et al. <a class="elsevierStyleCrossRef" href="#bib40">40</a> and da Fonte de Amorim et al. <a class="elsevierStyleCrossRef" href="#bib32">32</a> reported a lower risk of BC among Japanese and Brazilian carriers of the C variant allele. Moreover, an association between the <span class="elsevierStyleItalic">CYP1A1</span> T6235 C allele and a high BC risk was previously described by Taioli et al. <a class="elsevierStyleCrossRef" href="#bib20">20</a>,<a class="elsevierStyleCrossRef" href="#bib22">22</a>, Li et al. <a class="elsevierStyleCrossRef" href="#bib33">33</a>, Chacko et al. <a class="elsevierStyleCrossRef" href="#bib23">23</a>, Shen et al. <a class="elsevierStyleCrossRef" href="#bib24">24</a>, Gulyaeva et al. <a class="elsevierStyleCrossRef" href="#bib26">26</a>, Naushad et al. <a class="elsevierStyleCrossRef" href="#bib28">28</a> and Khvostova et al. <a class="elsevierStyleCrossRef" href="#bib29">29</a>. Discrepancies between the results of our study and the da Fonte de Amorim study <a class="elsevierStyleCrossRef" href="#bib32">32</a> (both studies were conducted among Brazilians) and discrepancies between the results of our study and those of Taioli <a class="elsevierStyleCrossRef" href="#bib20">20</a>,<a class="elsevierStyleCrossRef" href="#bib22">22</a> and Naushad <a class="elsevierStyleCrossRef" href="#bib28">28</a> (African-American and Indian women, respectively) may be attributed to different sample sizes. We analyzed 742 SBC patients. The studies by da Fonte de Amorim, Taioli and Naushad analyzed significantly smaller numbers of patients (n=128, n=57 and n=342, respectively). Conversely, the discrepancies between our study and the remaining discordant studies may be explained by ethnic variation within the populations because the frequency of the <span class="elsevierStyleItalic">CYP1A1</span> 6235TC+CC genotype was lower <a class="elsevierStyleCrossRef" href="#bib40">40</a> or higher <a class="elsevierStyleCrossRef" href="#bib23">23</a>,<a class="elsevierStyleCrossRef" href="#bib24">24</a>,<a class="elsevierStyleCrossRef" href="#bib26">26</a>,<a class="elsevierStyleCrossRef" href="#bib29">29</a>,<a class="elsevierStyleCrossRef" href="#bib33">33</a> among our controls compared to their controls.</p><p id="para140" class="elsevierStylePara elsevierViewall">Additionally, in our study, the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG and 4889AG+GG genotypes were overrepresented in Caucasian Brazilian women with BC compared with non-Caucasian women. The frequencies of the referred genotypes were also higher among our Caucasian SBC patients than in our control group. Therefore, Caucasian women carrying the G allele had a higher risk of SBC development. Our finding is consistent with the Sergentanis & Economopoulos meta-analysis <a class="elsevierStyleCrossRef" href="#bib52">52</a>, which included Caucasian, Chinese and African populations from 29 eligible studies. We also observed similar frequencies of the distinct <span class="elsevierStyleItalic">CYP1A1</span> T6235C polymorphisms among our Caucasian and non-Caucasian women. To the best of our knowledge, the association between the <span class="elsevierStyleItalic">CYP1A1</span> T6235 C allele and a high risk BC was only observed in a small study of North-Americans, which was conducted by Taioli et al. <a class="elsevierStyleCrossRef" href="#bib20">20</a>,<a class="elsevierStyleCrossRef" href="#bib22">22</a>.</p><p id="para150" class="elsevierStylePara elsevierViewall">We identified a relationship between the <span class="elsevierStyleItalic">CYP1A1</span> 6235CC genotype and SBC in women who experienced an earlier age at menarche compared to women who experienced a later age at menarche, as previously described by Huang et al. <a class="elsevierStyleCrossRef" href="#bib21">21</a>,<a class="elsevierStyleCrossRef" href="#bib39">39</a>. In fact, women with early menarche are exposed to estrogen for a longer period of time, which might amplify the effect of the <span class="elsevierStyleItalic">CYP1A1</span> 6235CC variant product on breast tissue. We also surprisingly found that the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG+GG genotype was overrepresented in SBC patients who experienced their FFTP earlier in life compared to women who experienced a later FFTP. An early age at FFTP is well-known to be highly protective against the onset of BC <a class="elsevierStyleCrossRef" href="#bib11">11</a>,<a class="elsevierStyleCrossRef" href="#bib53">53</a>,<a class="elsevierStyleCrossRef" href="#bib54">54</a> and the <span class="elsevierStyleItalic">CYP1A1</span> A4889G genotype is associated with an increased BC risk in women with an older age at FFTP <a class="elsevierStyleCrossRef" href="#bib55">55</a>,<a class="elsevierStyleCrossRef" href="#bib56">56</a> because of the prolonged estrogen exposure of the breast epithelium <a class="elsevierStyleCrossRef" href="#bib6">6</a>,<a class="elsevierStyleCrossRef" href="#bib10">10</a>. However, Brazilian women are characterized by a low average FFTP age and also by multiparity <a class="elsevierStyleCrossRef" href="#bib57">57</a>, which seem to be protective factors <a class="elsevierStyleCrossRef" href="#bib11">11</a>. However, Kobayashi et al. <a class="elsevierStyleCrossRef" href="#bib58">58</a> reported that each pregnancy, including the first one, increases the risk of early onset BC due to the reaction cascade triggered by chorionic gonadotropin hormone (hCG) during the first trimester of pregnancy. This cascade results in the morphological and functional development of breast tissue. The high progesterone conditions induced by hCG seem to be essential to pregnancy-associated breast development, presumably as a result of mammary epithelial stem cell expansion. This fact, associated with the high estrogen metabolism among multiparous women with the G variant allele, may explain our results. However, we did not determine how many pregnancies each woman had experienced until BC was diagnosed.</p><p id="para160" class="elsevierStylePara elsevierViewall">In our study and Huang et al. <a class="elsevierStyleCrossRef" href="#bib21">21</a>,<a class="elsevierStyleCrossRef" href="#bib39">39</a>, BC risk was higher among women with a high BMI. In Huang et al., the CC variant genotype of the <span class="elsevierStyleItalic">CYP1A1</span> T6235C polymorphism was overrepresented in pre-obese and obese women, suggesting that the CC variant might affect BC susceptibility. One plausible mechanism for this association is that obese women have a higher circulating estrogen level caused by the conversion of androgen to estrogen in adipose tissue. Apart from this possibility, obese women have a higher formation rate of genotoxic compounds that may lead to DNA adduct formation in mammary cells <a class="elsevierStyleCrossRef" href="#bib10">10</a>,<a class="elsevierStyleCrossRef" href="#bib11">11</a>.</p><p id="para170" class="elsevierStylePara elsevierViewall">Finally, we observed that the G and C variant alleles of both polymorphisms were positively associated with lower histological grade tumors, thereby indicating their roles in the progression of mammary carcinogenesis (even compared to controls). Thus, carriers of the respective variant alleles of both polymorphisms have an increased risk of developing histological grade I and II BC. Conflicting results regarding the roles of <span class="elsevierStyleItalic">CYP1A1</span> A4889G and T6235C in the histological grade of BC have been previously observed in small studies conducted by Miyoshi et al. <a class="elsevierStyleCrossRef" href="#bib40">40</a> (n=195) and Singh et al. <a class="elsevierStyleCrossRef" href="#bib36">36</a> (n=150).</p><p id="para180" class="elsevierStylePara elsevierViewall">Our data are useful for predicting BC risk. Our results showed that <span class="elsevierStyleItalic">CYP1A1</span> A4889G and T6235C polymorphisms alter the risk and clinical or tumor characteristics of BC among a heterogeneous population from Southeastern Brazil. Although this study is not the first study to investigate SBC in Brazil <a class="elsevierStyleCrossRef" href="#bib32">32</a>,<a class="elsevierStyleCrossRef" href="#bib37">37</a>, the large sample size provides more reliable conclusions regarding SBC among Brazilians.</p></span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">AUTHOR CONTRIBUTIONS</span><p id="para190" class="elsevierStylePara elsevierViewall">Lima CS was responsible for the study concepts, study design, quality control of the data and algorithms, data analysis, data interpretation, statistical analyses and manuscript review. Gurgel MS was responsible for the study design and quality control of the data and algorithms. Cardoso-Filho C and Bossi LS were responsible for data acquisition. Oliveira CM was responsible for data acquisition, data analysis, data interpretation, statistical analyses, manuscript preparation and manuscript editing. Lourenço GJ was responsible for statistical analyses.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xpalclavsec1582434" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "MATERIALS AND METHODS" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Study population" ] 1 => array:2 [ "identificador" => "cesec40" "titulo" => "Polymorphism analysis" ] 2 => array:2 [ "identificador" => "cesec50" "titulo" => "Statistical analyses" ] ] ] 3 => array:2 [ "identificador" => "cesec60" "titulo" => "RESULTS" ] 4 => array:2 [ "identificador" => "cesec70" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec80" "titulo" => "AUTHOR CONTRIBUTIONS" ] 6 => array:2 [ "identificador" => "xack639333" "titulo" => "ACKNOWLEDGMENTS" ] 7 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-01-25" "fechaAceptado" => "2015-07-21" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1582434" "palabras" => array:4 [ 0 => "Sporadic Breast Cancer" 1 => "<span class="elsevierStyleItalic">CYP1A1</span>" 2 => "Genetic Polymorphism" 3 => "Risk" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVES:</span><p id="spara30" class="elsevierStyleSimplePara elsevierViewall">We examined the influence of <span class="elsevierStyleItalic">CYP1A1</span> A4889G and T6235C polymorphisms on the risk of sporadic breast cancer.</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHOD:</span><p id="spara40" class="elsevierStyleSimplePara elsevierViewall">DNA from 742 sporadic breast cancer patients and 742 controls was analyzed using the polymerase chain reaction, followed by the restriction fragment length polymorphism technique.</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS:</span><p id="spara50" class="elsevierStyleSimplePara elsevierViewall">More patients had the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG+GG genotype compared to controls (29.0% <span class="elsevierStyleItalic">versus</span> 23.2%, <span class="elsevierStyleItalic">p</span>=0.004). The G allele carriers had a 1.50-fold increased risk (95% CI: 1.14–1.97) of sporadic breast cancer compared to the other study participants. The frequency of the 4889AG+GG genotype among the Caucasian patients was higher than in the non-Caucasian patients (30.4% <span class="elsevierStyleItalic">versus</span> 20.2%, <span class="elsevierStyleItalic">p</span>=0.03) and controls (30.4% <span class="elsevierStyleItalic">versus</span> 23.2%, <span class="elsevierStyleItalic">p</span>=0.002). Caucasians and G allele carriers had a 1.61-fold increased risk (95% CI: 1.20–2.15) of sporadic breast cancer compared to other subjects. The <span class="elsevierStyleItalic">CYP1A1</span> 4889AG+GG genotype was more common among patients with a younger median age at first full-term pregnancy than among controls (33.8% <span class="elsevierStyleItalic">versus</span> 23.2%, <span class="elsevierStyleItalic">p</span>=0.001) and subjects whose first full-term pregnancies occurred at an older age (33.8% <span class="elsevierStyleItalic">versus</span> 26.1%, <span class="elsevierStyleItalic">p</span>=0.03). Women with the <span class="elsevierStyleItalic">CYP1A1</span> 4889AG+GG genotype and earlier first full-term pregnancies had a 1.87-fold (95% CI: 1.32–2.67) increased risk of sporadic breast cancer compared to the other study participants. Excess <span class="elsevierStyleItalic">CYP1A1</span> 4889AG+GG (39.8% <span class="elsevierStyleItalic">versus</span> 27.1%, <span class="elsevierStyleItalic">p</span>=0.01) and 6235TC+CC (48.4% <span class="elsevierStyleItalic">versus</span> 35.9%, <span class="elsevierStyleItalic">p</span>=0.02) genotypes were also observed in patients with grade I and II tumors compared to patients with grade III tumors and controls (39.8% <span class="elsevierStyleItalic">versus</span> 23.2%, <span class="elsevierStyleItalic">p=</span>0.04; 48.4% <span class="elsevierStyleItalic">versus</span> 38.6%, <span class="elsevierStyleItalic">p=</span>0.04). The G and C allele carriers had a 2.44-fold (95% CI: 1.48–4.02) and 1.67-fold (95% CI: 1.03–2.69) increased risk, respectively, of developing grade I and II tumors compared to other subjects.</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSIONS:</span><p id="spara60" class="elsevierStyleSimplePara elsevierViewall">The <span class="elsevierStyleItalic">CYP1A1</span> A4889G and T6235C polymorphisms may alter the risk of sporadic breast cancer in Brazilian women.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVES:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "METHOD:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "RESULTS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "CONCLUSIONS:" ] ] ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara" id="cenpara30">No potential conflict of interest was reported.</p>" ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">Genotypes \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Patients Number (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Controls Number (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"><span class="elsevierStyleItalic">p-</span>value \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">OR<a class="elsevierStyleCrossRef" href="#tfn1">*</a> (95% CI<span class="elsevierStyleSup">a</span>) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">A4889G</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>AA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">527 (71.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">570 (76.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">reference \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>AG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">195 (26.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">157 (21.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">0.01</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">1.45 (1.10-1.93)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>GG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">20 (2.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">15 (2.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">2.05 (0.89-4.71) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>AA \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">527 (71.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">570 (76.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">reference \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>AG+GG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">215 (29.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">172 (23.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">0.004</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">1.50 (1.14-1.97)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>AA+AG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">722 (97.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">727 (98.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">reference \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>GG \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">20 (2.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">15 (2.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">1.84 (0.81-4.20) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">T6235C</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>TT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">464 (62.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">456 (61.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">reference \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>TC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">236 (31.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">243 (32.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">1.00 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">1.00 (0.77-1.30) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">42 (5.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">43 (5.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.74 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">1.09 (0.65-1.83) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>TT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">464 (62.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">456 (61.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">reference \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>TC+CC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">278 (37.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">286 (38.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.90 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">1.01 (0.79-1.30) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>TT+TC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">700 (94.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">699 (94.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">reference \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>CC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">42(5.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">43 (5.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">1.10 (0.66-1.83) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">A4889G/T6235C</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="4" align="left" valign="top"></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>AA+TT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">413 (74.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">438 (76.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">reference \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>AG+TC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">128 (23.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">123 (21.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">1.25 (0.90-1.74) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>GG+CC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">13 (2.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">13 (2.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">1.59 (0.61-4.15) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>AA+TT \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">413 (71.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">438 (74.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">reference \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>AG+GG+TC+CC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">164 (28.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">154 (26.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">1.26 (0.93-1.70) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>AA+AG+TT+TC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">693 (98.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">697 (98.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">reference \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleHsp" style=""></span>GG+CC \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">13 (1.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">13 (1.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">0.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">1.45 (0.56-3.74) \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tfn1" "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">: Adjusted odds ratio for age and ethnic origin; <span class="elsevierStyleBold"><span class="elsevierStyleSup">a</span></span>: confidence interval. The significant results are shown in a bold font.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">CYP1A1</span> genotypes among sporadic breast cancer patients and controls.</p>" ] ] 1 => array:7 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:2 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="7" align="center" valign="bottom" scope="col"><span class="elsevierStyleItalic">CYP1A1</span> A4889G polymorphism</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="bottom" scope="col">Features \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">No<span class="elsevierStyleSup">a</span> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">AA \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">AG \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">GG \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">AA+AG \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">GG \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">AA \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">AG+GG \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">Ethnical origin</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">742 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Caucasian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">638 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">444 (69.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">178 (27.9)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">16 (2.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">622 (97.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">16 (2.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">444 (69.6)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">194 (30.4)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Non-Caucasian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">104 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">83 (79.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">17 (16.3)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">4 (3.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">100 (96.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">4 (3.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">83 (79.8)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">21 (20.2)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleItalic">p-</span>value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"><span class="elsevierStyleBold">0.01</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.64 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"><span class="elsevierStyleBold">0.03</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">MAM<span class="elsevierStyleSup">b</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">693<span class="elsevierStyleBold"><span class="elsevierStyleSup">c</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">younger than 13 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">298 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">202 (67.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">89 (29.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">7 (2.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">291 (97.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">7 (2.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">202 (67.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">96 (32.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">13 years and older \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">395 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">289 (73.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">93 (23.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">13 (3.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">382 (96.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">13 (3.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">289 (73.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">106 (26.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleItalic">p-</span>value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">MAFFTP<span class="elsevierStyleSup">d</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">692<span class="elsevierStyleBold"><span class="elsevierStyleSup">c</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">younger than 22 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">275 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">182 (66.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">82 (29.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">11 (4.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">264 (96.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">11 (4.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">182 (66.2)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">93 (33.8)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">22 years and older \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">417 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">306 (73.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">103 (24.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">8 (1.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">409 (98.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">8 (1.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">306 (73.4)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">111 (26.1)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleItalic">p-</span>value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.11 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"><span class="elsevierStyleBold">0.03</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">Body mass index</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">708<span class="elsevierStyleSup">c</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Under+normal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">253 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">185 (73.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">63 (24.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">5 (2.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">248 (98.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">5 (2.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">185 (73.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">68 (26.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Pre-obese+obese \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">455 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">316 (69.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">125 (27.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">14 (3.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">441 (97.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">14 (3.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">306 (69.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">139 (30.5) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleItalic">p-</span>value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.29 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">Histological grade</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">642<span class="elsevierStyleBold"><span class="elsevierStyleSup">c</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">I+II \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">93 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">56 (60.2)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">35 (37.6)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">2 (2.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">91 (97.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">2 (2.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">56 (60.2)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">37 (39.8)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">549 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">400 (72.9)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">132 (24.0)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">17 (3.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">532 (96.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">17 (3.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">400 (72.9)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">149 (27.1)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleItalic">p-</span>value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"><span class="elsevierStyleBold">0.008</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.83 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"><span class="elsevierStyleBold">0.01</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] 1 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="7" align="center" valign="top" scope="col"><span class="elsevierStyleItalic">CYP1A1</span> T6235C polymorphism</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="bottom" scope="col">Features \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">No<a class="elsevierStyleCrossRef" href="#tfn2"><span class="elsevierStyleSup">a</span></a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">TT \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">TC \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">CC \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">TT+TC \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">CC \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">TT \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">TC+CC \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">Ethnical origin</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">742 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Caucasian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">638 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">403 (63.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">202 (31.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">33 (5.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">605 (94.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">33 (5.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">403 (63.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">235 (36.8) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Non-Caucasian \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">104 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">61 (58.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">34 (32.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">9 (8.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">95 (91.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">9 (8.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">61 (58.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">43 (41.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleItalic">p-</span>value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.70 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">MAM<span class="elsevierStyleSup">b</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">693<span class="elsevierStyleBold"><span class="elsevierStyleSup">c</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">younger than 13 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">298 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">181 (60.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">94 (31.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">23 (7.7)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">275 (92.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">23 (7.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">181 (60.7) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">117 (39.3) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">13 years and older \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">395 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">255 (64.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">124 (31.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">16 (4.0)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">379 (96.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">16 (4.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">255 (64.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">140 (35.4) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleItalic">p-</span>value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.78 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"><span class="elsevierStyleBold">0.04</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.37 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">MAFFTP<span class="elsevierStyleSup">d</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">692<span class="elsevierStyleBold"><span class="elsevierStyleSup">c</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">younger than 22 years \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">275 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">165 (60.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">94 (34.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">16 (5.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">259 (94.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">16 (5.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">165 (60.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">110 (40.0) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">22 years and older \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">417 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">263 (63.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">129 (30.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">25 (6.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">392 (94.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">25 (6.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">263 (63.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">154 (36.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleItalic">p-</span>value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.39 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.93 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.87 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">Body mass index</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">708<span class="elsevierStyleSup">c</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Under+normal \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">253 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">159 (62.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">84 (33.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">10 (4.0) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">243 (96.0)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">10 (4.0)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">159 (62.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">94 (37.2) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Pre-obese+obese \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">455 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">287 (63.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">137 (30.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">31 (6.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">424 (93.2)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">31 (6.8)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">287 (63.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">168 (36.9) \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleItalic">p-</span>value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.72 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"><span class="elsevierStyleBold">0.04</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleBold">Histological grade</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">642<span class="elsevierStyleBold"><span class="elsevierStyleSup">c</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">I+II \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">93 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">48 (51.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">37 (39.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">8 (8.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">85 (91.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">8 (8.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">48 (51.6)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">45 (48.4)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">III \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">549 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">352 (64.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">169 (30.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">28 (5.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">521 (94.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top">28 (5.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">352 (64.1)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"><span class="elsevierStyleBold">197 (35.9)</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top"><span class="elsevierStyleItalic">p-</span>value \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.07 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.18 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"><span class="elsevierStyleBold">0.02</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tfn2" "etiqueta" => "a" "nota" => "<p class="elsevierStyleNotepara" id="cenpara20">: number; <span class="elsevierStyleBold"><span class="elsevierStyleSup">b</span></span>: Median age at menarche; <span class="elsevierStyleBold"><span class="elsevierStyleSup">c</span></span>: The total number differs from the total (742) number quoted in the study because it was not possible to obtain information for some individuals; <span class="elsevierStyleBold"><span class="elsevierStyleSup">d</span></span>: Median age at first full-term pregnancy. The significant results are presented in a bold font.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">. <span class="elsevierStyleItalic">CYP1A1</span> genotypes among sporadic breast cancer patients stratified by the clinical features and biological aspects of the tumor</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:58 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Population prevalence of familial cancer and common hereditary cancer syndromes; The 2005 California Health Interview Survey" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ MT Scheuner \n \t\t\t\t\t\t\t\t """ 1 => """ TS McNeel \n \t\t\t\t\t\t\t\t """ 2 => """ AN Freedman \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1097/GIM.0b013e3181f30e9e" "Revista" => array:7 [ "tituloSerie" => "Genet Med" "fecha" => "2010" "volumen" => "12" "numero" => "11" "paginaInicial" => "726" "paginaFinal" => "735" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20921897" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1097/GIM.0b013e3181f30e9e" "WWW" => array:1 [ "link" => "10.1097/GIM.0b013e3181f30e9e" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ongoing research to identify environmental risk factors in breast carcinoma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ MC Johnson-Thompson \n \t\t\t\t\t\t\t\t """ 1 => """ J Guthrie \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/(sici)1097-0142(20000301)88:5+<1224::aid-cncr8>3.3.co;2-8" "Revista" => array:7 [ "tituloSerie" => "Cancer" "fecha" => "2000" "volumen" => "88" "numero" => "5 Suppl" "paginaInicial" => "1224" "paginaFinal" => "1229" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10705359" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetics of CYP1A1: coamplification of specific alleles by polymerase chain reaction and association with breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ T Rebbeck \n \t\t\t\t\t\t\t\t """ 1 => """ E Rosvold \n \t\t\t\t\t\t\t\t """ 2 => """ D Duggan \n \t\t\t\t\t\t\t\t """ 3 => """ J Zhang \n \t\t\t\t\t\t\t\t """ 4 => """ K Buetow \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Epidemiol Biomarkers Prev" "fecha" => "1994" "volumen" => "3" "numero" => "6" "paginaInicial" => "511" "paginaFinal" => "514" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8000303" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Carcinogen-DNA adducts in human breast tissue" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ FP Perera \n \t\t\t\t\t\t\t\t """ 1 => """ A Estabrook \n \t\t\t\t\t\t\t\t """ 2 => """ A Hewer \n \t\t\t\t\t\t\t\t """ 3 => """ K Channing \n \t\t\t\t\t\t\t\t """ 4 => """ A Rundle \n \t\t\t\t\t\t\t\t """ 5 => """ LA Mooney \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Epidemiol Biomarkers Prev" "fecha" => "1995" "volumen" => "4" "numero" => "3" "paginaInicial" => "233" "paginaFinal" => "238" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7606197" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer risk in the Nurses' Health Study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ N Ishibe \n \t\t\t\t\t\t\t\t """ 1 => """ SE Hankinson \n \t\t\t\t\t\t\t\t """ 2 => """ GA Colditz \n \t\t\t\t\t\t\t\t """ 3 => """ D Spiegelman \n \t\t\t\t\t\t\t\t """ 4 => """ WC Willett \n \t\t\t\t\t\t\t\t """ 5 => """ FE Speizer \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Res" "fecha" => "1998" "volumen" => "58" "numero" => "4" "paginaInicial" => "667" "paginaFinal" => "671" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9485019" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Understanding breast cancer risk – where do we stand in 2005" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ RG Dumitrescu \n \t\t\t\t\t\t\t\t """ 1 => """ I Cotarla \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1111/j.1582-4934.2005.tb00350.x" "Revista" => array:7 [ "tituloSerie" => "J Cell Mol Med" "fecha" => "2005" "volumen" => "9" "numero" => "1" "paginaInicial" => "208" "paginaFinal" => "221" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15784178" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1111/j.1582-4934.2005.tb00350.x" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1111/j.1582-4934.2005.tb00350.x" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A prospective study of estradiol and breast cancer in Japanese women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ M Kabuto \n \t\t\t\t\t\t\t\t """ 1 => """ S Akiba \n \t\t\t\t\t\t\t\t """ 2 => """ RG Stevens \n \t\t\t\t\t\t\t\t """ 3 => """ K Neriishi \n \t\t\t\t\t\t\t\t """ 4 => """ CE Land \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Epidemiol Biomarkers Prev" "fecha" => "2000" "volumen" => "9" "numero" => "6" "paginaInicial" => "575" "paginaFinal" => "579" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10868691" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atypical hyperplastic lesions of the female breas: a longterm follow-up study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ DL Page \n \t\t\t\t\t\t\t\t """ 1 => """ WD Dupont \n \t\t\t\t\t\t\t\t """ 2 => """ LW Rogers \n \t\t\t\t\t\t\t\t """ 3 => """ MS Rados \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1002/1097-0142(19850601)55:11<2698::aid-cncr2820551127>3.0.co;2-a" "Revista" => array:7 [ "tituloSerie" => "Cancer" "fecha" => "1985" "volumen" => "55" "numero" => "11" "paginaInicial" => "2698" "paginaFinal" => "2708" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2986821" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1002/1097-0142(19850601)55:11<2698::aid-cncr2820551127>3.0.co;2-a" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1002/1097-0142(19850601)55:11<2698::AID-CNCR2820551127>3.0.CO;2-A" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endogenous estrogens as carcinogens through metabolic activation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ JD Yager \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Natl Cancer Inst Monogr" "fecha" => "2000" "numero" => "27" "paginaInicial" => "67" "paginaFinal" => "73" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Molecular epidemiology of sporadic breast cancer. The role of polymorphic genes involved in oestrogen biosynthesis and metabolism" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ K Mitrunen \n \t\t\t\t\t\t\t\t """ 1 => """ A Hirvonen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/s1383-5742(03)00016-4" "Revista" => array:7 [ "tituloSerie" => "Mutat Res" "fecha" => "2003" "volumen" => "544" "numero" => "1" "paginaInicial" => "9" "paginaFinal" => "41" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12888106" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/s1383-5742(03)00016-4" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/S1383-5742(03)00016-4" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Associations of breast cancer risk factors with tumor subtypes: a pooled analysis from the Breast Cancer Association Consortium studies" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ XR Yang \n \t\t\t\t\t\t\t\t """ 1 => """ J Chang-Claude \n \t\t\t\t\t\t\t\t """ 2 => """ EL Goode \n \t\t\t\t\t\t\t\t """ 3 => """ FJ Couch \n \t\t\t\t\t\t\t\t """ 4 => """ H Nevanlinna \n \t\t\t\t\t\t\t\t """ 5 => """ RL Milne \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1093/jnci/djq526" "Revista" => array:7 [ "tituloSerie" => "J Natl Cancer Inst" "fecha" => "2011" "volumen" => "103" "numero" => "3" "paginaInicial" => "250" "paginaFinal" => "263" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21191117" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1093/jnci/djq526" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1093/jnci/djq526" ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ MM de Jong \n \t\t\t\t\t\t\t\t """ 1 => """ IM Nolte \n \t\t\t\t\t\t\t\t """ 2 => """ GJ te Meerman \n \t\t\t\t\t\t\t\t """ 3 => """ WT van der Graaf \n \t\t\t\t\t\t\t\t """ 4 => """ JC Oosterwijk \n \t\t\t\t\t\t\t\t """ 5 => """ JH Kleibeuker \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1136/jmg.39.4.225" "Revista" => array:7 [ "tituloSerie" => "J Med Genet" "fecha" => "2002" "volumen" => "39" "numero" => "4" "paginaInicial" => "225" "paginaFinal" => "242" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11950848" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1136/jmg.39.4.225" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1136/jmg.39.4.225" ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ LF Masson \n \t\t\t\t\t\t\t\t """ 1 => """ L Sharp \n \t\t\t\t\t\t\t\t """ 2 => """ SC Cotton \n \t\t\t\t\t\t\t\t """ 3 => """ J Little \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/aje/kwi121" "Revista" => array:7 [ "tituloSerie" => "Am J Epidemiol" "fecha" => "2005" "volumen" => "161" "numero" => "10" "paginaInicial" => "901" "paginaFinal" => "915" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15870154" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assignment of the human 2,4,7,8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P1-450 gene to chromosome 15" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ CE Hildebrand \n \t\t\t\t\t\t\t\t """ 1 => """ FJ Gonzalez \n \t\t\t\t\t\t\t\t """ 2 => """ OW McBride \n \t\t\t\t\t\t\t\t """ 3 => """ DM Nebert \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1093/nar/13.6.2009" "Revista" => array:7 [ "tituloSerie" => "Nucleic Acids Res" "fecha" => "1985" "volumen" => "13" "numero" => "6" "paginaInicial" => "2009" "paginaFinal" => "2016" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4000952" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1093/nar/13.6.2009" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1093/nar/13.6.2009" ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Associations between breast cancer susceptibility gene polymorphisms and clinicopathological features" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ W Han \n \t\t\t\t\t\t\t\t """ 1 => """ D Kang \n \t\t\t\t\t\t\t\t """ 2 => """ IA Park \n \t\t\t\t\t\t\t\t """ 3 => """ SW Kim \n \t\t\t\t\t\t\t\t """ 4 => """ JY Bae \n \t\t\t\t\t\t\t\t """ 5 => """ KW Chung \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1158/1078-0432.ccr-0834-3" "Revista" => array:7 [ "tituloSerie" => "Clin Cancer Res" "fecha" => "2004" "volumen" => "10" "numero" => "1 Pt 1" "paginaInicial" => "124" "paginaFinal" => "130" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14734460" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Real-time genotyping of cytochrome P4501A1 A4889G and T6235C polymorphisms" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ V Harth \n \t\t\t\t\t\t\t\t """ 1 => """ T Brüning \n \t\t\t\t\t\t\t\t """ 2 => """ J Abel \n \t\t\t\t\t\t\t\t """ 3 => """ B Koch \n \t\t\t\t\t\t\t\t """ 4 => """ I Berg \n \t\t\t\t\t\t\t\t """ 5 => """ A Sachinidis \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1006/mcpr.2001.0349" "Revista" => array:7 [ "tituloSerie" => "Mol Cell Probes" "fecha" => "2001" "volumen" => "15" "numero" => "2" "paginaInicial" => "93" "paginaFinal" => "97" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11292327" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1006/mcpr.2001.0349" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1006/mcpr.2001.0349" ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Activation of procarcinogens by human cytochrome P450 enzymes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ FP Guengerich \n \t\t\t\t\t\t\t\t """ 1 => """ T Shimada \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/s0027-5107(98)00037-2" "Revista" => array:7 [ "tituloSerie" => "Mutat Res" "fecha" => "1998" "volumen" => "400" "numero" => "1-2" "paginaInicial" => "201" "paginaFinal" => "213" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9685642" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/s0027-5107(98)00037-2" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/S0027-5107(98)00037-2" ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association between CYP1A1 genotype, mRNA expression and enzymatic activity in humans" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ MT Landi \n \t\t\t\t\t\t\t\t """ 1 => """ PA Bertazzi \n \t\t\t\t\t\t\t\t """ 2 => """ PG Shields \n \t\t\t\t\t\t\t\t """ 3 => """ G Clark \n \t\t\t\t\t\t\t\t """ 4 => """ GW Lucier \n \t\t\t\t\t\t\t\t """ 5 => """ SJ Garte \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1097/00008571-199410000-00002" "Revista" => array:7 [ "tituloSerie" => "Pharmacogenetics" "fecha" => "1994" "volumen" => "4" "numero" => "5" "paginaInicial" => "242" "paginaFinal" => "246" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7894496" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1097/00008571-199410000-00002" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1097/00008571-199410000-00002" ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytochrome p450 1A1 and glutathione S-tansferase (M1) genetic polymorphisms and postmenopausal breast cancer risk" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ C Ambrosone \n \t\t\t\t\t\t\t\t """ 1 => """ J Freudenheim \n \t\t\t\t\t\t\t\t """ 2 => """ S Graham \n \t\t\t\t\t\t\t\t """ 3 => """ J Marshall \n \t\t\t\t\t\t\t\t """ 4 => """ J Vena \n \t\t\t\t\t\t\t\t """ 5 => """ J Brasure \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Res" "fecha" => "1995" "volumen" => "55" "numero" => "16" "paginaInicial" => "3483" "paginaFinal" => "3485" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7627950" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A CYP1A1 restriction fragment length polymorphism is associated with breast cancer in African-American women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ E Taioli \n \t\t\t\t\t\t\t\t """ 1 => """ J Trachman \n \t\t\t\t\t\t\t\t """ 2 => """ X Chen \n \t\t\t\t\t\t\t\t """ 3 => """ P Toniolo \n \t\t\t\t\t\t\t\t """ 4 => """ S Garte \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Res" "fecha" => "1995" "volumen" => "55" "numero" => "17" "paginaInicial" => "3757" "paginaFinal" => "3758" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7641189" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cytochrome P4501A1 polymorphism as a susceptibility factor for breast cancer in postmenopausal Chinese women in Taiwan" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ CS Huang \n \t\t\t\t\t\t\t\t """ 1 => """ CY Shen \n \t\t\t\t\t\t\t\t """ 2 => """ KJ Chang \n \t\t\t\t\t\t\t\t """ 3 => """ SM Hsu \n \t\t\t\t\t\t\t\t """ 4 => """ HD Chern \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1038/sj.bjc.6690608" "Revista" => array:7 [ "tituloSerie" => "Br J Cancer" "fecha" => "1999" "volumen" => "80" "numero" => "11" "paginaInicial" => "1838" "paginaFinal" => "1843" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10468307" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1038/sj.bjc.6690608" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1038/sj.bjc.6690608" ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of estradiol metabolism and CYP1A1 polymorphisms in breast cancer risk" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ E Taioli \n \t\t\t\t\t\t\t\t """ 1 => """ HL Bradlow \n \t\t\t\t\t\t\t\t """ 2 => """ SV Garbers \n \t\t\t\t\t\t\t\t """ 3 => """ DW Sepkovic \n \t\t\t\t\t\t\t\t """ 4 => """ MP Osborne \n \t\t\t\t\t\t\t\t """ 5 => """ J Trachman \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1046/j.1525-1500.1999.09912.x" "Revista" => array:7 [ "tituloSerie" => "Cancer Detect Prev" "fecha" => "1999" "volumen" => "23" "numero" => "3" "paginaInicial" => "232" "paginaFinal" => "237" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10337002" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1046/j.1525-1500.1999.09912.x" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1046/j.1525-1500.1999.09912.x" ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of xenobiotic metabolizing gene polymorphisms in breast cancer susceptibility and treatment outcome" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ P Chacko \n \t\t\t\t\t\t\t\t """ 1 => """ T Joseph \n \t\t\t\t\t\t\t\t """ 2 => """ BS Mathew \n \t\t\t\t\t\t\t\t """ 3 => """ B Rajan \n \t\t\t\t\t\t\t\t """ 4 => """ MR Pillai \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/j.mrgentox.2004.11.018" "Revista" => array:7 [ "tituloSerie" => "Mutat Res" "fecha" => "2005" "volumen" => "581" "numero" => "1-2" "paginaInicial" => "153" "paginaFinal" => "163" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15725614" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/j.mrgentox.2004.11.018" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/j.mrgentox.2004.11.018" ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Joint effects of the CYP1A1 MspI, ERalpha PvuII, and ERalpha XbaI polymorphisms on the risk of breast cancer: results from a population-based case-control study in Shanghai, China" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ CY Shen \n \t\t\t\t\t\t\t\t """ 1 => """ DK Li \n \t\t\t\t\t\t\t\t """ 2 => """ J Wy \n \t\t\t\t\t\t\t\t """ 3 => """ Z Zhang \n \t\t\t\t\t\t\t\t """ 4 => """ E Gao \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1158/1055-9965.EPI-05-0485" "Revista" => array:7 [ "tituloSerie" => "Cancer Epidemiol Biomarkers Prev" "fecha" => "2006" "volumen" => "15" "numero" => "2" "paginaInicial" => "342" "paginaFinal" => "347" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16492926" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1158/1055-9965.EPI-05-0485" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1158/1055-9965.EPI-05-0485" ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A study on the association of cytochrome-P450 A1A polymorphism and breast cancer risk in North Indian women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ V Singh \n \t\t\t\t\t\t\t\t """ 1 => """ N Rastogi \n \t\t\t\t\t\t\t\t """ 2 => """ A Sinha \n \t\t\t\t\t\t\t\t """ 3 => """ A Kumar \n \t\t\t\t\t\t\t\t """ 4 => """ N Mathur \n \t\t\t\t\t\t\t\t """ 5 => """ MP Singh \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s10549-006-9264-2" "Revista" => array:7 [ "tituloSerie" => "Breast Cancer Res Treat" "fecha" => "2007" "volumen" => "101" "numero" => "1" "paginaInicial" => "73" "paginaFinal" => "81" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16807674" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s10549-006-9264-2" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/s10549-006-9264-2" ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Comparative analysis of SNP in estrogen-metabolizing enzymes for ovarian, endometrial, and breast cancers in Novosibirsk, Russia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ LF Gulyaeva \n \t\t\t\t\t\t\t\t """ 1 => """ ON Mikhailova \n \t\t\t\t\t\t\t\t """ 2 => """ VO PustyInyak \n \t\t\t\t\t\t\t\t """ 3 => """ IV Kim \n \t\t\t\t\t\t\t\t """ 4 => """ AV Gerasimov \n \t\t\t\t\t\t\t\t """ 5 => """ SE Krasilnikov \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/978-0-387-69080-3_34" "Revista" => array:6 [ "tituloSerie" => "Adv Exp Med Biol" "fecha" => "2008" "volumen" => "617" "paginaInicial" => "359" "paginaFinal" => "366" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18497059" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/978-0-387-69080-3_34" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/978-0-387-69080-3" ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of CYP1A1*2 polymorphisms with breast cancer risk: a case control study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ D Surekha \n \t\t\t\t\t\t\t\t """ 1 => """ K Sailaja \n \t\t\t\t\t\t\t\t """ 2 => """ DN Rao \n \t\t\t\t\t\t\t\t """ 3 => """ T Padma \n \t\t\t\t\t\t\t\t """ 4 => """ D Raghunadharao \n \t\t\t\t\t\t\t\t """ 5 => """ S Vishnupriya \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Indian J Med Sci" "fecha" => "2009" "volumen" => "63" "numero" => "1" "paginaInicial" => "13" "paginaFinal" => "20" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19346634" "web" => "Medline" ] ] ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "http://dx.doi.org/10.4103/0019-5359.49077" ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cross-talk between one-carbon metabolism and xenobiotics metabolism: implications on oxidative DNA damage and susceptibility to breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ SM Naushad \n \t\t\t\t\t\t\t\t """ 1 => """ CA Reddy \n \t\t\t\t\t\t\t\t """ 2 => """ AP Rupasree \n \t\t\t\t\t\t\t\t """ 3 => """ RR Digumarti \n \t\t\t\t\t\t\t\t """ 4 => """ SR Gottumukkala \n \t\t\t\t\t\t\t\t """ 5 => """ P Kuppusamy \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s12013-011-9245-x" "Revista" => array:7 [ "tituloSerie" => "Cell Biochem Biophys" "fecha" => "2011" "volumen" => "61" "numero" => "3" "paginaInicial" => "715" "paginaFinal" => "723" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21792634" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s12013-011-9245-x" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/s12013-011-9245-x" ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic polymorphism of estrogen metabolizing enzymes in Siberian women with breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ EP Khvostova \n \t\t\t\t\t\t\t\t """ 1 => """ VO Pustylnyak \n \t\t\t\t\t\t\t\t """ 2 => """ LF Gulyaeva \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1089/gtmb.2011.0131" "Revista" => array:7 [ "tituloSerie" => "Genet Test Mol Biomarkers" "fecha" => "2012" "volumen" => "16" "numero" => "3" "paginaInicial" => "167" "paginaFinal" => "173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21977969" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1089/gtmb.2011.0131" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1089/gtmb.2011.0131" ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breast cancer and CYPIA1, GSTM1, and GSTT1 polymorphisms: evidence of a lack of association in Caucasians and African Americans" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ LR Bailey \n \t\t\t\t\t\t\t\t """ 1 => """ N Roodi \n \t\t\t\t\t\t\t\t """ 2 => """ CS Verrier \n \t\t\t\t\t\t\t\t """ 3 => """ CJ Yee \n \t\t\t\t\t\t\t\t """ 4 => """ WD Dupont \n \t\t\t\t\t\t\t\t """ 5 => """ FF Parl \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Res" "fecha" => "1998" "volumen" => "58" "numero" => "1" "paginaInicial" => "65" "paginaFinal" => "70" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9426059" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polymorphisms in <span class="elsevierStyleItalic">CYP1A1</span> and smoking: no association with breast cancer risk" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ VM Basham \n \t\t\t\t\t\t\t\t """ 1 => """ PDP Pharoah \n \t\t\t\t\t\t\t\t """ 2 => """ CS Healey \n \t\t\t\t\t\t\t\t """ 3 => """ RN Luben \n \t\t\t\t\t\t\t\t """ 4 => """ NE Day \n \t\t\t\t\t\t\t\t """ 5 => """ DF Easton \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1093/carcin/22.11.1797" "Revista" => array:7 [ "tituloSerie" => "Carcinogenesis" "fecha" => "2001" "volumen" => "22" "numero" => "11" "paginaInicial" => "1797" "paginaFinal" => "1800" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11698341" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1093/carcin/22.11.1797" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1093/carcin/22.11.1797" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "<span class="elsevierStyleItalic">CYP1A1</span>, <span class="elsevierStyleItalic">GSTM1</span>, and <span class="elsevierStyleItalic">GSTT1</span> polymorphisms and breast cancer risk in Brazilian women" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ LM Da Fonte de Amorim \n \t\t\t\t\t\t\t\t """ 1 => """ A Rossini \n \t\t\t\t\t\t\t\t """ 2 => """ GAS Mendonça \n \t\t\t\t\t\t\t\t """ 3 => """ PF Lotsch \n \t\t\t\t\t\t\t\t """ 4 => """ TA Simão \n \t\t\t\t\t\t\t\t """ 5 => """ CVM Gallo \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/s0304-3835(02)00058-7" "Revista" => array:7 [ "tituloSerie" => "Cancer Lett" "fecha" => "2002" "volumen" => "181" "numero" => "2" "paginaInicial" => "179" "paginaFinal" => "186" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12175533" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/s0304-3835(02)00058-7" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/S0304-3835(02)00058-7" ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cigarette smoking, cytochrome P4501A1 polymorphisms, and breast cancer among African-American and white women" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ Y Li \n \t\t\t\t\t\t\t\t """ 1 => """ RC Millikan \n \t\t\t\t\t\t\t\t """ 2 => """ DA Bell \n \t\t\t\t\t\t\t\t """ 3 => """ L Cui \n \t\t\t\t\t\t\t\t """ 4 => """ CKJ Tse \n \t\t\t\t\t\t\t\t """ 5 => """ B Newman \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1186/bcr814" "Revista" => array:7 [ "tituloSerie" => "Breast Cancer Res" "fecha" => "2004" "volumen" => "6" "numero" => "4" "paginaInicial" => "R460" "paginaFinal" => "R473" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15217514" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1186/bcr814" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1186/bcr814" ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polymorphisms in <span class="elsevierStyleItalic">CYP1A1</span> and breast carcinoma risk in a population-based case-control study in Chinese women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ SM Boyapati \n \t\t\t\t\t\t\t\t """ 1 => """ XO Shu \n \t\t\t\t\t\t\t\t """ 2 => """ YT Gao \n \t\t\t\t\t\t\t\t """ 3 => """ Q Cai \n \t\t\t\t\t\t\t\t """ 4 => """ F Jin \n \t\t\t\t\t\t\t\t """ 5 => """ W Zheng \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1002/cncr.21056" "Revista" => array:7 [ "tituloSerie" => "Cancer" "fecha" => "2005" "volumen" => "103" "numero" => "11" "paginaInicial" => "2228" "paginaFinal" => "2235" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15856430" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1002/cncr.21056" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1002/cncr.21056" ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Estrogen metabolizing polymorphisms and breast cancer risk among older white women" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ F Modugno \n \t\t\t\t\t\t\t\t """ 1 => """ JM Zmuda \n \t\t\t\t\t\t\t\t """ 2 => """ D Potter \n \t\t\t\t\t\t\t\t """ 3 => """ C Cai \n \t\t\t\t\t\t\t\t """ 4 => """ E Ziv \n \t\t\t\t\t\t\t\t """ 5 => """ SR Cummings \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s10549-005-5347-8" "Revista" => array:7 [ "tituloSerie" => "Breast Cancer Res Treat" "fecha" => "2005" "volumen" => "93" "numero" => "3" "paginaInicial" => "261" "paginaFinal" => "270" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16142442" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s10549-005-5347-8" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/s10549-005-5347-8" ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Association of CYP1A1 Polymorphisms with Breast Cancer in North Indian Women" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ N Singh \n \t\t\t\t\t\t\t\t """ 1 => """ AK Mitra \n \t\t\t\t\t\t\t\t """ 2 => """ VK Garg \n \t\t\t\t\t\t\t\t """ 3 => """ A Agarwal \n \t\t\t\t\t\t\t\t """ 4 => """ M Sharma \n \t\t\t\t\t\t\t\t """ 5 => """ R Chaturvedi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.3727/000000007783629972" "Revista" => array:7 [ "tituloSerie" => "Oncol Res" "fecha" => "2007" "volumen" => "16" "numero" => "12" "paginaInicial" => "587" "paginaFinal" => "597" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18351133" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.3727/000000007783629972" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.3727/000000007783629972" ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Genetic polymorphisms in oestrogen metabolic pathway and breast cancer: a positive association with combined CYP/GST genotypes" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ C Torresan \n \t\t\t\t\t\t\t\t """ 1 => """ MMC Oliveira \n \t\t\t\t\t\t\t\t """ 2 => """ GT Torrezan \n \t\t\t\t\t\t\t\t """ 3 => """ SFV Oliveira \n \t\t\t\t\t\t\t\t """ 4 => """ CS Abuázar \n \t\t\t\t\t\t\t\t """ 5 => """ R Losi-Guembarovski \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s10238-008-0159-x" "Revista" => array:7 [ "tituloSerie" => "Clin Exp Med" "fecha" => "2008" "volumen" => "8" "numero" => "2" "paginaInicial" => "65" "paginaFinal" => "71" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18618215" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s10238-008-0159-x" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/s10238-008-0159-x" ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of ethnicity in cancer susceptibility gene polymorphisms: the example of CYP1A1" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ S Garte \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1093/carcin/19.8.1329" "Revista" => array:7 [ "tituloSerie" => "Carcinogenesis" "fecha" => "1998" "volumen" => "19" "numero" => "8" "paginaInicial" => "1329" "paginaFinal" => "1332" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9744524" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1093/carcin/19.8.1329" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1093/carcin/19.8.1329" ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breast cancer risk associated with genotype polymorphism of the estrogen-metabolizing genes <span class="elsevierStyleItalic">CYP17</span>, <span class="elsevierStyleItalic">CYP1A1</span>, and <span class="elsevierStyleItalic">COMT</span>: a multigenic study on cancer susceptibility" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ CS Huang \n \t\t\t\t\t\t\t\t """ 1 => """ HD Chern \n \t\t\t\t\t\t\t\t """ 2 => """ KJ Chang \n \t\t\t\t\t\t\t\t """ 3 => """ CW Cheng \n \t\t\t\t\t\t\t\t """ 4 => """ SM Hsu \n \t\t\t\t\t\t\t\t """ 5 => """ CY Shen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Res" "fecha" => "1999" "volumen" => "59" "numero" => "19" "paginaInicial" => "4870" "paginaFinal" => "4875" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10519398" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breast cancer risk associated with <span class="elsevierStyleItalic">CYP1A1</span> genetic polymorphisms in Japanese women" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ Y Miyoshi \n \t\t\t\t\t\t\t\t """ 1 => """ Y Takahashi \n \t\t\t\t\t\t\t\t """ 2 => """ C Egawa \n \t\t\t\t\t\t\t\t """ 3 => """ S Noguchi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1046/j.1524-4741.2002.08404.x" "Revista" => array:7 [ "tituloSerie" => "Breast J" "fecha" => "2002" "volumen" => "8" "numero" => "4" "paginaInicial" => "209" "paginaFinal" => "215" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12100112" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1046/j.1524-4741.2002.08404.x" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1046/j.1524-4741.2002.08404.x" ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Do single nucleotide polymorphisms in xenobiotic metabolizing genes determine breast cancer susceptibility and treatment outcomes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ V Singh \n \t\t\t\t\t\t\t\t """ 1 => """ D Parmar \n \t\t\t\t\t\t\t\t """ 2 => """ MP Singh \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1080/07357900801953196" "Revista" => array:7 [ "tituloSerie" => "Cancer Invest" "fecha" => "2008" "volumen" => "26" "numero" => "8" "paginaInicial" => "769" "paginaFinal" => "783" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18798070" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1080/07357900801953196" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1080/07357900801953196" ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The genomic ancestry of individuals from different geographical regions of Brazil is more uniform than expected" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ SD Pena \n \t\t\t\t\t\t\t\t """ 1 => """ G Di Pietro \n \t\t\t\t\t\t\t\t """ 2 => """ M Fuchshuber-Moraes \n \t\t\t\t\t\t\t\t """ 3 => """ JP Genro \n \t\t\t\t\t\t\t\t """ 4 => """ MH Hutz \n \t\t\t\t\t\t\t\t """ 5 => """ S Kehdy Fde \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "PLoS One" "fecha" => "2011" "volumen" => "6" "numero" => "2" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1371/journal.pone.0017063" ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Incidência de Câncer no Brasil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ Instituto Nacional de Câncer (INCA), Brasil \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:2 [ "tituloSerie" => "Estimativa" "fecha" => "2014" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "Ministério da Saúde 2013; http://www.inca.gov.br/estimativa/2014" ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "BMI Classification" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ World Health Organization (WHO) \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:2 [ "link" => "http://apps.who.int/bmi/index.jsp?introPage=intro_3.html" "fecha" => "2004" ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pathological prognostic factors in breast cancer. The value of histological grade in breast cancer: experience from a large study with long-term follow-up" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ CW Elston \n \t\t\t\t\t\t\t\t """ 1 => """ IO Ellis \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1111/j.1365-2559.1991.tb00229.x" "Revista" => array:7 [ "tituloSerie" => "Histopathology" "fecha" => "1991" "volumen" => "19" "numero" => "5" "paginaInicial" => "403" "paginaFinal" => "410" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1757079" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1111/j.1365-2559.1991.tb00229.x" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1111/j.1365-2559.1991.tb00229.x" ] ] ] ] ] ] 45 => array:3 [ "identificador" => "bib46" "etiqueta" => "46" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breast" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ FL Greene \n \t\t\t\t\t\t\t\t """ 1 => """ DL Page \n \t\t\t\t\t\t\t\t """ 2 => """ ID Fleming \n \t\t\t\t\t\t\t\t """ 3 => """ A Fritz \n \t\t\t\t\t\t\t\t """ 4 => """ CM Balch \n \t\t\t\t\t\t\t\t """ 5 => """ DG Haller \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:6 [ "editores" => "C MBalch" "titulo" => "American Joint Committee on Cancer; Cancer staging manual" "paginaInicial" => "223" "paginaFinal" => "240" "edicion" => "6th edition" "serieFecha" => "2002" ] ] ] ] ] ] 46 => array:3 [ "identificador" => "bib47" "etiqueta" => "47" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ SM Hsu \n \t\t\t\t\t\t\t\t """ 1 => """ L Raine \n \t\t\t\t\t\t\t\t """ 2 => """ H Fanger \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ajcp/75.5.734" "Revista" => array:7 [ "tituloSerie" => "Am J Clin Pathol" "fecha" => "1981" "volumen" => "75" "numero" => "5" "paginaInicial" => "734" "paginaFinal" => "738" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6165237" "web" => "Medline" ] ] ] ] ] ] ] ] 47 => array:3 [ "identificador" => "bib48" "etiqueta" => "48" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A C4887A polymorphism in exon 7 of human <span class="elsevierStyleItalic">CYP1A1</span>: population frequency, mutation linkages, and impact on lung cancer susceptibility" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ I Cascorbi \n \t\t\t\t\t\t\t\t """ 1 => """ J Brockmöller \n \t\t\t\t\t\t\t\t """ 2 => """ I Roots \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Res" "fecha" => "1996" "volumen" => "56" "numero" => "21" "paginaInicial" => "4965" "paginaFinal" => "4969" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8895751" "web" => "Medline" ] ] ] ] ] ] ] ] 48 => array:3 [ "identificador" => "bib49" "etiqueta" => "49" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical Trials: A Practical Approach" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ SJ Pocock \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1983" "editorial" => "John Wiley and Sons" "editorialLocalizacion" => "New York" ] ] ] ] ] ] 49 => array:3 [ "identificador" => "bib50" "etiqueta" => "50" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Designing Clinical Research" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ SB Hulley \n \t\t\t\t\t\t\t\t """ 1 => """ SR Cummings \n \t\t\t\t\t\t\t\t """ 2 => """ WS Browner \n \t\t\t\t\t\t\t\t """ 3 => """ DG Grady \n \t\t\t\t\t\t\t\t """ 4 => """ TB Newman \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Libro" => array:3 [ "fecha" => "1988" "editorial" => "Lippincott Williams and Wilkins" "editorialLocalizacion" => "Philadelphia" ] ] ] ] ] ] 50 => array:3 [ "identificador" => "bib51" "etiqueta" => "51" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "DSS Research Statistical Power Calculators" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ Decision Support Systems \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:2 [ "link" => "http://www.dssresearch.com/KnowledgeCenter/toolkitcalculators/statisticalpowercalculators.aspx" "fecha" => "2013" ] ] ] ] ] ] 51 => array:3 [ "identificador" => "bib52" "etiqueta" => "52" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Four polymorphisms in cytochrome P450 1A1 (CYP1A1) gene and breast cancer risk: a meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ TN Sergentanis \n \t\t\t\t\t\t\t\t """ 1 => """ KP Economopoulos \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s10549-009-0694-5" "Revista" => array:7 [ "tituloSerie" => "Breast Cancer Res Treat" "fecha" => "2010" "volumen" => "122" "numero" => "2" "paginaInicial" => "459" "paginaFinal" => "469" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20035380" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s10549-009-0694-5" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/s10549-009-0694-5" ] ] ] ] ] ] 52 => array:3 [ "identificador" => "bib53" "etiqueta" => "53" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reproductive factors and breast cancer risk according to joint estrogen and progesterone receptor status: a meta-analysis of epidemiological studies" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ H Ma \n \t\t\t\t\t\t\t\t """ 1 => """ L Bernstein \n \t\t\t\t\t\t\t\t """ 2 => """ MC Pike \n \t\t\t\t\t\t\t\t """ 3 => """ G Ursin \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1186/bcr1525" "Revista" => array:6 [ "tituloSerie" => "Breast Cancer Res" "fecha" => "2006" "volumen" => "8" "numero" => "4" "paginaInicial" => "R43" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16859501" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1186/bcr1525" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1186/bcr1525" ] ] ] ] ] ] 53 => array:3 [ "identificador" => "bib54" "etiqueta" => "54" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breast cancer risk and hormone receptor status in older women by parity, age of first birth, and breastfeeding - a case-control study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ SJ Lord \n \t\t\t\t\t\t\t\t """ 1 => """ L Bernstein \n \t\t\t\t\t\t\t\t """ 2 => """ KA Johnson \n \t\t\t\t\t\t\t\t """ 3 => """ KE Malone \n \t\t\t\t\t\t\t\t """ 4 => """ JA McDonald \n \t\t\t\t\t\t\t\t """ 5 => """ PA Marchbanks \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1158/1055-9965.EPI-07-2824" "Revista" => array:7 [ "tituloSerie" => "Cancer Epidemiol Biomarkers Prev" "fecha" => "2008" "volumen" => "17" "numero" => "7" "paginaInicial" => "1723" "paginaFinal" => "1730" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18628424" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1158/1055-9965.EPI-07-2824" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1158/1055-9965.EPI-07-2824" ] ] ] ] ] ] 54 => array:3 [ "identificador" => "bib55" "etiqueta" => "55" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "ABC of breast cancer diseases. Breast cancer-epidemiology, risk factors, and genetics" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ K McPherson \n \t\t\t\t\t\t\t\t """ 1 => """ CM Steel \n \t\t\t\t\t\t\t\t """ 2 => """ JM Dizon \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1136/bmj.321.7261.624" "Revista" => array:7 [ "tituloSerie" => "BMJ" "fecha" => "2000" "volumen" => "321" "numero" => "7261" "paginaInicial" => "624" "paginaFinal" => "628" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10977847" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1136/bmj.321.7261.624" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1136/bmj.321.7261.624" ] ] ] ] ] ] 55 => array:3 [ "identificador" => "bib56" "etiqueta" => "56" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Epidemiology of endocrine-related risk factors for breast cancer" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ L Bernstein \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1023/a:1015714305420" "Revista" => array:7 [ "tituloSerie" => "J Mammary Gland Biol Neoplasia" "fecha" => "2002" "volumen" => "7" "numero" => "1" "paginaInicial" => "3" "paginaFinal" => "15" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12160084" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1023/a:1015714305420" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1023/A:1015714305420" ] ] ] ] ] ] 56 => array:3 [ "identificador" => "bib57" "etiqueta" => "57" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breast Cancer in an Area of High Parity: São Paulo, Brazil" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ AP Mirra \n \t\t\t\t\t\t\t\t """ 1 => """ P Cole \n \t\t\t\t\t\t\t\t """ 2 => """ B MacMahon \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Cancer Res" "fecha" => "1971" "volumen" => "31" "numero" => "2" "paginaInicial" => "77" "paginaFinal" => "83" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5545272" "web" => "Medline" ] ] ] ] ] ] ] ] 57 => array:3 [ "identificador" => "bib58" "etiqueta" => "58" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reproductive history and breast cancer risk" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ S Kobayashi \n \t\t\t\t\t\t\t\t """ 1 => """ H Sugiura \n \t\t\t\t\t\t\t\t """ 2 => """ Y Ando \n \t\t\t\t\t\t\t\t """ 3 => """ N Shiraki \n \t\t\t\t\t\t\t\t """ 4 => """ T Yanagi \n \t\t\t\t\t\t\t\t """ 5 => """ H Yamashita \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s12282-012-0384-8" "Revista" => array:7 [ "tituloSerie" => "Breast Cancer" "fecha" => "2012" "volumen" => "19" "numero" => "4" "paginaInicial" => "302" "paginaFinal" => "308" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22711317" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s12282-012-0384-8" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1007/s12282-012-0384-8" ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack639333" "titulo" => "ACKNOWLEDGMENTS" "texto" => "<p id="para200" class="elsevierStylePara elsevierViewall">This work was supported by the Fundação à Pesquisa do Estado de São Paulo (FAPESP).</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000007000000010/v1_202212011450/S1807593222013266/v1_202212011450/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000007000000010/v1_202212011450/S1807593222013266/v1_202212011450/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222013266?idApp=UINPBA00004N" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 0 | 2 |
| 2024 October | 21 | 21 | 42 |
| 2024 September | 14 | 11 | 25 |
| 2024 August | 16 | 22 | 38 |
| 2024 July | 11 | 22 | 33 |
| 2024 June | 16 | 15 | 31 |
| 2024 May | 11 | 15 | 26 |
| 2024 April | 14 | 10 | 24 |
| 2024 March | 27 | 17 | 44 |
| 2024 February | 18 | 8 | 26 |
| 2024 January | 11 | 14 | 25 |
| 2023 December | 15 | 18 | 33 |
| 2023 November | 29 | 16 | 45 |
| 2023 October | 20 | 11 | 31 |
| 2023 September | 25 | 13 | 38 |
| 2023 August | 8 | 4 | 12 |
| 2023 July | 3 | 9 | 12 |
| 2023 June | 3 | 6 | 9 |
| 2023 April | 2 | 0 | 2 |
| 2023 March | 2 | 1 | 3 |
| 2023 February | 1 | 0 | 1 |
| 2023 January | 0 | 2 | 2 |
| 2022 December | 6 | 3 | 9 |
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