CLINICAL SCIENCE
Liver lobe-based magnetic resonance diffusion-weighted imaging using multiple b values in patients with hepatitis B-related liver cirrhosis: association with the liver disease severity according to the Child-Pugh class
Hong-Jie TangI,II, Li ZhouI,III, Xiao-Ming ZhangI, Jun LiuIV, Tian-Wu ChenI,
, Nan-Lin ZengI, Dan WangI, Jie LiI, Yu-Cheng HuangI, Yu-Lian TangI, Jiani HuV
Corresponding author
I Affiliated Hospital of North Sichuan Medical College, Department of Radiology, Sichuan Key Laboratory of Medical Imaging, Nanchong, Sichuan, China
II Nanchong Traditional Chinese Medicine Hospital, Department of Radiology, Nanchong, Sichuan, China.
III Affiliated Gaoxin Hospital of Xi′an Medical College, Department of Imaging Centre, Xi′an, Shanxi, China.
IV Second Xiangya Hospital of Central South University, Department of Radiology, Changsha, Hunan, China.
V Wayne State University, Department of Radiology, Detroit, Michigan, USA.
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The ROM were measured under 2 N·m torque loading pressure. <span class="elsevierStyleBold">A)</span> the fusion group showed a significantly restricted ROM of C3∼C7 regarding flexion, extension and axial rotation ROM of C3∼C7 compared to the intact group and non-fusion group. No significant difference of ROM in any direction was detected when compared the intact group and non-fusion group. <span class="elsevierStyleBold">B)</span> the fusion group and non-fusion group showed a significantly increased ROM of C3∼4 regarding extension and lateral bending ROM of C3∼4 compared to the intact group. Significant difference of ROM of C3∼4 in axial rotation was detected when compared the intact group and non-fusion group. <span class="elsevierStyleBold">C)</span> the fusion group showed a significantly restricted ROM of C4∼6 in all directions compared to the intact group and non-fusion group. Comparing with the intact group, the extension and lateral bending ROM of C4∼6 in non-fusion group increased significantly. <span class="elsevierStyleBold">D)</span> the fusion group showed a significantly restricted ROM of C6∼7 in extension compared to the intact group and non-fusion group. The axial rotation ROM of C6∼7 in non-fusion group decreased significantly comparing with the fusion group. 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"Hong-Jie" "apellidos" => "Tang" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">II</span>" "identificador" => "aff2" ] ] ] 1 => array:3 [ "nombre" => "Li" "apellidos" => "Zhou" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">III</span>" "identificador" => "aff3" ] ] ] 2 => array:3 [ "nombre" => "Xiao-Ming" "apellidos" => "Zhang" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] ] ] 3 => array:3 [ "nombre" => "Jun" "apellidos" => "Liu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">IV</span>" "identificador" => "aff4" ] ] ] 4 => array:4 [ "nombre" => "Tian-Wu" "apellidos" => "Chen" "email" => array:1 [ 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"apellidos" => "Tang" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1" ] ] ] 10 => array:3 [ "nombre" => "Jiani" "apellidos" => "Hu" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">V</span>" "identificador" => "aff5" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Affiliated Hospital of North Sichuan Medical College, Department of Radiology, Sichuan Key Laboratory of Medical Imaging, Nanchong, Sichuan, China" "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "Nanchong Traditional Chinese Medicine Hospital, Department of Radiology, Nanchong, Sichuan, China." "etiqueta" => "II" "identificador" => "aff2" ] 2 => array:3 [ "entidad" => "Affiliated Gaoxin Hospital of Xi′an Medical College, Department of Imaging Centre, Xi′an, Shanxi, China." "etiqueta" => "III" "identificador" => "aff3" ] 3 => array:3 [ "entidad" => "Second Xiangya Hospital of Central South University, Department of Radiology, Changsha, Hunan, China." "etiqueta" => "IV" "identificador" => "aff4" ] 4 => array:3 [ "entidad" => "Wayne State University, Department of Radiology, Detroit, Michigan, USA." "etiqueta" => "V" "identificador" => "aff5" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Corresponding Author:" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 595 "Ancho" => 742 "Tamanyo" => 66148 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">In a 47-year-old male with Child–Pugh Class C liver cirrhosis, three regions of interest were drawn in each of the left lateral liver lobe, the left medial liver lobe, the right liver lobe, and the caudate lobe for measurement using a b value of 0 sec/mm<span class="elsevierStyleSup">2</span> (A). These regions of interest were identically positioned on the corresponding liver lobes for the measurement of b<span class="elsevierStyleInf">(0,500)</span> (B), b<span class="elsevierStyleInf">(0,800)</span> (C) and b<span class="elsevierStyleInf">(0,1000)</span> (D) by the software to obtain the corresponding apparent diffusion coefficients.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Liver cirrhosis is defined as the histological development of regenerative nodules surrounded by fibrous bands in response to chronic hepatitis <a class="elsevierStyleCrossRef" href="#bib1">1</a>. Liver biopsy is the gold standard method to diagnose cirrhosis; however, it is not feasible in all patients with cirrhosis due to the invasiveness of this procedure and its sampling variability and may not be a desirable option for decompensated cirrhosis <a class="elsevierStyleCrossRef" href="#bib1">1</a>,<a class="elsevierStyleCrossRef" href="#bib2">2</a>. The assessment of liver cirrhosis severity plays a crucial role in selecting therapeutic approaches and monitoring patient responses to clinical interventions <a class="elsevierStyleCrossRef" href="#bib2">2</a>. Laboratory tests (e.g., Child-Pugh classification) and clinical parameters (the presence of complications such as ascites) are used to assess liver disease severity.</p><p id="para20" class="elsevierStylePara elsevierViewall">To assess cirrhosis, magnetic resonance (MR) diffusion-weighted imaging (DWI) not only provides anatomical and structural information but also reflects functional attributes of tissues by quantifying the process of water diffusion based on the apparent diffusion coefficient (ADC) <a class="elsevierStyleCrossRef" href="#bib3">3</a>. Previous studies have reported that the ADC of cirrhotic liver was lower than that of normal liver <a class="elsevierStyleCrossRef" href="#bib4">4</a>–<a class="elsevierStyleCrossRef" href="#bib7">7</a>. In most of these published studies, the liver ADC was measured in the right liver lobe rather than in each liver lobe to evaluate liver cirrhosis; this approach was primarily used to correlate the liver ADC with the biopsy specimen, which is typically acquired from the right liver lobe. Hsu et al. <a class="elsevierStyleCrossRef" href="#bib4">4</a> reported that patients with Child-Pugh Class A cirrhosis exhibited a reduced liver ADC based on measurement of the right liver lobe compared to individuals with normal liver function. Luciani et al. <a class="elsevierStyleCrossRef" href="#bib5">5</a> used a respiratory-triggered acquisition with 10 b values to perform a DWI study of the right and left liver lobes and found that the ADC of either lobe significantly decreased in patients with cirrhosis compared to healthy volunteers and that there was no significant difference in the ADC between the right and left liver lobes.</p><p id="para30" class="elsevierStylePara elsevierViewall">It is well known that hypertrophy of the caudate and left lateral liver lobes and atrophy of the right liver lobe and the left medial liver lobe occur when a healthy liver progresses to the stage of compensated cirrhosis <a class="elsevierStyleCrossRef" href="#bib6">6</a>–<a class="elsevierStyleCrossRef" href="#bib8">8</a>. We explored whether the ADCs of individual liver lobes are different between cirrhotic patients and healthy individuals and whether the ADCs for individual liver lobes distinctly correlate with the presence and Child-Pugh class of cirrhosis. Therefore, the aim of this study was to determine the associations of individual liver lobe ADCs obtained using multiple b values with the presence and Child-Pugh class of cirrhosis and to evaluate the difference in ADCs between any two liver lobes in cirrhotic patients with hepatitis B.</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">MATERIALS AND METHODS</span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">Participant selection</span><p id="para40" class="elsevierStylePara elsevierViewall">This prospective study was approved by the institutional ethics review board of our hospital, and written informed consent was obtained from each participant prior to their participation in this study.</p><p id="para50" class="elsevierStylePara elsevierViewall">The patients were enrolled in our study according to the following inclusion criteria: (1) the initial diagnosis of cirrhosis in patients with hepatitis B was based on physical findings, laboratory investigations, imaging findings and histopathological findings whenever available according to the American Association for the Study of Liver Diseases (AASLD) practice guidelines on chronic hepatitis B (2007) <a class="elsevierStyleCrossRef" href="#bib9">9</a>; (2) the patients underwent abdominal MR scans and Child-Pugh score calculation based on 5 parameters, including albumin, ascites, bilirubin, prothrombin activity and encephalopathy; and (3) imaging data showed that the patients lacked portal vein emboli and hepatic carcinoma. From March 2013 to February 2014, there were 81 consecutive patients with cirrhosis resulting from hepatitis B. In this cohort, 53 cases were confirmed by liver biopsy, and the remaining 28 cases were diagnosed based on physical findings, laboratory investigations and MR findings according to the AASLD practice guidelines because they had contraindications for liver puncture biopsy. In this cohort, 31 patients had portal hypertension, whereas 23 patients did not, as demonstrated by endoscopy (n=54); the remaining 27 patients did not undergo this examination because of their contraindications.</p><p id="para60" class="elsevierStylePara elsevierViewall">The exclusion criteria were as follows: (1) patients with active gastrointestinal bleeding (n=2); (2) patients with a history of treatment for portal hypertension, including splenectomy, partial spleen embolization, transjugular intrahepatic portosystemic shunt, β-blocker therapy, blood transfusion therapy or endoscopic therapy, before the MR scans and biochemical tests (n=2); (3) patients with other etiologies such as portal vein thrombosis, parasitic diseases and hematological malignancies needed to be excluded (n=1); and (4) patients with malignant liver lesions or alcohol addiction (n=1) or patients with sepsis, large-volume ascites, impaired renal function, or hemolysis (n=1). Of the 81 consecutive cirrhotic patients, 7 patients were excluded from this study. Consequently, 74 cirrhotic patients were included in this study.</p><p id="para70" class="elsevierStylePara elsevierViewall">In the cohort of enrolled cirrhotic patients, the mean age was 56 years (range, 23–81 years); 47 patients (63.5%) were men, and 27 patients (36.5%) were women. A biochemical test was performed to determine the Child-Pugh scores, and no more than a 2-day delay was allowed between the biochemical tests and the MR scans. As a result, 23, 27 and 24 patients were classified as having Child-Pugh Class A, B or C cirrhosis, respectively. In addition, the enrolled patients underwent medical or surgical treatment for portal hypertension and other conditions after definitive diagnoses were made based on the MR scans and biochemical tests.</p><p id="para80" class="elsevierStylePara elsevierViewall">During the same research period, a control group of 25 random consecutive healthy volunteers (14 men, 11 women; mean age, 52 years; range, 21–76 years) who underwent upper abdominal MR scans for physical examination at our institution served as the reference group. The inclusion criteria for the controls were no history of liver disease, hepatocellular carcinoma, or fatty liver and normal serum liver enzyme levels. Hepatitis B and C surface antigen tests revealed negative findings in all volunteers.</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">MR imaging protocol</span><p id="para90" class="elsevierStylePara elsevierViewall">The cirrhotic and healthy participants in our study underwent MR imaging using a 3.0 T whole-body imaging system (Signa; GE Medical Systems, Milwaukee, WI) equipped with a 32-channel phased-array body coil. After employing routine MR sequences, including axial two-dimensional spoiled gradient recalled echo T1-weighted imaging (T1WI) and axial fast recovery fast spin-echo T2-weighted imaging (T2WI) with fat suppression, DWI was performed using b values of 0, 500, 800 and 1000 s/mm<span class="elsevierStyleSup">2</span> prior to contrast agent injection for conventional contrast-enhanced MR scans. DWI was performed using a single-shot echo-planar imaging fat-suppressed sequence in the axial plane with respiratory-triggered acquisitions. The diffusion-weighted images for the four b values were obtained during one acquisition. The DWI sequence parameters were as follows: repetition time of 4800 msec, echo time of 49 msec, slice thickness of 7 mm, inter-slice gap of 2 mm, field of view of 34 × 34 cm, matrix of 256 × 192, number of excitations of 2, and acquisition time of 38 sec, resulting in the acquisition of 18 contiguous transverse sections. In addition, T1WI, T2WI and contrast-enhanced MR scans, each performed during one breath hold, were used to detect portal vein emboli, hepatocellular carcinoma, and fatty liver to determine whether the participant should be enrolled in our study.</p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">DWI data analysis</span><p id="para100" class="elsevierStylePara elsevierViewall">The original DWI data were directly interfaced and forwarded to the workstation (GE Advantage Workstation Version 4.4–09; Sun Microsystems, Palo Alto, CA, USA). The DWI data were analyzed according to the consensus of two radiologists (the first and second authors, with 5 and 4 years of experience in whole-body MR imaging, respectively) who were blinded to the clinical data. The ADCs for b<span class="elsevierStyleInf">(0,500)</span>, b<span class="elsevierStyleInf">(0,800)</span> or b<span class="elsevierStyleInf">(0,1000)</span> were derived from the signal intensity averaged across images obtained using b values of 0 and 500 sec/mm<span class="elsevierStyleSup">2</span>, 0 and 800 sec/mm<span class="elsevierStyleSup">2</span>, or 0 and 1000 sec/mm<span class="elsevierStyleSup">2</span>, respectively, using a software plug-in for a monoexponential model. Both radiologists performed the ADC calculations on defined circular regions of interest (ROIs), excluding vessels and motion artifacts, of approximately 50 mm<span class="elsevierStyleSup">2</span> in the left medial liver lobe or the caudate lobe or of 200 mm<span class="elsevierStyleSup">2</span> in the left lateral or right liver lobe. The liver was divided into four lobes, including the left lateral liver lobe (LLL), the left medial liver lobe (LML), the right liver lobe (RL), and the caudate lobe (CL). As shown in <a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>, we applied three ROIs per liver lobe to obtain the b value for 0 sec/mm<span class="elsevierStyleSup">2</span>, totaling 12 ROIs per participant; the ROIs were identically positioned on the corresponding ADC maps for b<span class="elsevierStyleInf">(0,500)</span>, b<span class="elsevierStyleInf">(0,800)</span> and b<span class="elsevierStyleInf">(0,1000)</span>, which were automatically generated by the software. The final liver lobe-based ADCs used for the analysis were the averaged ADCs of the three ROIs for b<span class="elsevierStyleInf">(0,500)</span>, b<span class="elsevierStyleInf">(0,800)</span> or b<span class="elsevierStyleInf">(0,1000)</span> for each liver lobe.</p><elsevierMultimedia ident="fig1"></elsevierMultimedia><p id="para110" class="elsevierStylePara elsevierViewall">To determine the reproducibility of the ADC measurements in cirrhotic and healthy participants, individual liver lobe ADCs for b<span class="elsevierStyleInf">(0,500)</span>, b<span class="elsevierStyleInf">(0,800)</span> and b<span class="elsevierStyleInf">(0,1000)</span> were measured repeatedly by two additional observers (the fifth and seventh authors, with 16 years and 3 years of experience in whole-body MR imaging, respectively) according to consensus.</p></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">Statistical analysis</span><p id="para120" class="elsevierStylePara elsevierViewall">SPSS version 17.0 (SPSS Inc., Chicago, IL, USA) was used for statistical analysis. Descriptive statistics of ADCs included the means and standard deviations (SDs). A <span class="elsevierStyleItalic">P-</span>value of less than 0.05 was considered to represent a significant difference.</p><p id="para130" class="elsevierStylePara elsevierViewall">To determine the reproducibility of individual liver lobe ADC measurements, the precision of the repeated measurements was determined as the coefficient of variation (CV) using the following formula: CV (%)=(s/X) × 100, where s is the SD and X is the mean ADC <a class="elsevierStyleCrossRef" href="#bib10">10</a>. The resultant precision was expressed as an averaged CV. When the CV was less than 10%, inter-observer variability of the ADC was regarded as small, and the ADC of the first measurement was used as the final value. When CV was greater than 10%, the mean value of the two measurements was used as the final ADC for the subsequent analysis <a class="elsevierStyleCrossRef" href="#bib11">11</a>.</p><p id="para140" class="elsevierStylePara elsevierViewall">Spearman's rank correlation analysis was used to test the correlation of liver lobe-based ADCs with the Child-Pugh class of cirrhosis. The liver lobe-based ADCs were compared between participants stratified by Child-Pugh class and between any two liver lobes in cirrhotic patients using Mann-Whitney U tests together with Bonferroni corrections for multiple comparisons. If there were significant positive findings on the above-mentioned tests for any liver lobe-based ADC in patients stratified by Child-Pugh class, the cutoff value of the potentially distinguishing ADC was then determined via receiver operating characteristic (ROC) analysis of the area under the ROC curve (AUC) for the determination of the Child-Pugh class of cirrhosis.</p></span></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">RESULTS</span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">Reproducibility of ADC measurements</span><p id="para150" class="elsevierStylePara elsevierViewall">For the two measurement sessions of liver lobe-based ADCs in the 74 cirrhotic patients and 25 healthy volunteers, the mean CV for the liver lobe-based ADCs and the number of subjects with a CV of less than or greater than 10% are listed in <a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>. In participants with an inter-observer variability of less than 10% for the liver lobe-based ADCs, the variability was regarded as small, and the values of the first measurement were used as the final ADCs. In participants with an inter-observer variability of ≥ 10% for the ADC, specifically in the LLL and the LML, an average of the two measurements was used as the final ADC.</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia></span><span id="cesec90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">Correlation of the liver lobe-based ADCs with the Child-Pugh class of cirrhosis</span><p id="para160" class="elsevierStylePara elsevierViewall">Liver lobe-based ADCs corresponding to healthy volunteers and patients with cirrhosis of Child-Pugh Class A, B or C are presented in <a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>. As shown in <a class="elsevierStyleCrossRef" href="#tbl3">Table 3</a>, inverse correlations of ADC for b<span class="elsevierStyleInf">(0,500)</span> or b<span class="elsevierStyleInf">(0,800)</span> with the Child-Pugh class of cirrhosis were found in the LLL, the LML, the RL and the CL (all <span class="elsevierStyleItalic">p<</span>0.05); an inverse correlation was observed between the Child-Pugh class and the ADC for b<span class="elsevierStyleInf">(0,1000)</span> in the LLL, the RL and the CL (all <span class="elsevierStyleItalic">p<</span>0.05) but not in the LML (<span class="elsevierStyleItalic">p></span>0.05).</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia><elsevierMultimedia ident="tbl3"></elsevierMultimedia></span><span id="cesec100" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle150">Comparison of the ADCs between participants stratified by Child-Pugh class and between any two liver lobes in cirrhotic patients</span><p id="para170" class="elsevierStylePara elsevierViewall">In the comparisons of ADCs between participants with normal liver function and those with each Child-Pugh class of cirrhosis (<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>), Mann-Whitney U tests together with Bonferroni corrections showed that the ADCs for b<span class="elsevierStyleInf">(0,500)</span> in the LLL and the CL and for b<span class="elsevierStyleInf">(0,800)</span> in the CL and the RL were significantly different between the normal liver and the Child-Pugh Class A cirrhotic liver. The ADCs for b<span class="elsevierStyleInf">(0,500)</span> in the LLL and the CL, for b<span class="elsevierStyleInf">(0,800)</span> in the LML, the RL and the CL, and for b<span class="elsevierStyleInf">(0,1000)</span> in the CL were significantly different between the normal liver and the Child-Pugh Class B cirrhotic liver. The ADCs for b<span class="elsevierStyleInf">(0,500)</span> and b<span class="elsevierStyleInf">(0,800)</span> in the LLL, the LML, the RL and the CL and for b<span class="elsevierStyleInf">(0,1000)</span> in the RL and the CL were different between the normal liver and the Child-Pugh Class C cirrhotic liver.</p><p id="para180" class="elsevierStylePara elsevierViewall">In the comparisons of ADCs between each Child-Pugh class of cirrhosis (<a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a>), the ADCs for b<span class="elsevierStyleInf">(0,500)</span> in the LLL, the RL and the CL, for b<span class="elsevierStyleInf">(0,800)</span> in the LML, the RL and the CL, and for b<span class="elsevierStyleInf">(0,1000)</span> in the CL were different between the normal liver and the Child-Pugh Class A–C cirrhotic liver. The ADCs for b<span class="elsevierStyleInf">(0,800)</span> in the RL and for b<span class="elsevierStyleInf">(0,1000)</span> in the CL were different between Class A and Classes B–C, and the ADCs for b<span class="elsevierStyleInf">(0,500)</span> in the LML and for b<span class="elsevierStyleInf">(0,800)</span> in the RL were different between Classes A–B and Class C.</p><elsevierMultimedia ident="tbl4"></elsevierMultimedia><p id="para190" class="elsevierStylePara elsevierViewall">In the comparisons of ADCs between any two liver lobes in cirrhotic patients (<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>), the ADCs were different between the RL and all other liver lobes for b<span class="elsevierStyleInf">(0,500)</span> and b<span class="elsevierStyleInf">(0,1000)</span> and between the RL and both the CL and the LLL for b<span class="elsevierStyleInf">(0,800)</span> (all <span class="elsevierStyleItalic">p<</span>0.008).</p></span><span id="cesec110" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle160">ROC analysis of ADCs for determining the Child-Pugh class of cirrhosis</span><p id="para200" class="elsevierStylePara elsevierViewall">Significant differences in the ADCs were found between the normal liver and the Child-Pugh Class A–C cirrhotic liver, between Class A and Classes B–C, and between Classes A–B and Class C, as shown in <a class="elsevierStyleCrossRef" href="#tbl4">Table 4</a>. Therefore, ROC analysis of the ADCs was performed to determine the cutoff values of the ADCs and the AUC, sensitivity and specificity of these cutoff values for the presence and Child-Pugh class of cirrhosis, as shown in <a class="elsevierStyleCrossRef" href="#tbl5">Table 5</a>. Among the liver lobe-based ADCs, the ADC for b<span class="elsevierStyleInf">(0,500)</span> in the LLL displayed the largest AUC for identifying the presence of cirrhosis. The ADC for b<span class="elsevierStyleInf">(0,800)</span> in the RL displayed the largest AUC for distinguishing Child-Pugh Class A from Classes B–C cirrhosis and for discriminating Child-Pugh Classes A–B from Class C.</p><elsevierMultimedia ident="tbl5"></elsevierMultimedia></span></span><span id="cesec120" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle170">DISCUSSION</span><p id="para210" class="elsevierStylePara elsevierViewall">The management of patients with cirrhosis should now focus on prevention and early intervention to stabilize disease progression and to avoid or delay clinical decompensation to improve patient prognosis <a class="elsevierStyleCrossRef" href="#bib12">12</a>. To assess liver cirrhosis progression, the Child-Pugh classification system is occasionally regarded as a clinical measurement of liver function in the setting of liver cirrhosis <a class="elsevierStyleCrossRef" href="#bib13">13</a>. This system has several drawbacks that could be influenced by a variety of internal and external factors in patients with cirrhosis. For example, patients with a bilirubin concentration of 55 μm have a better prognosis than those with a bilirubin concentration of 250 μm, but both groups of patients have the same severity score according to the bilirubin concentration <a class="elsevierStyleCrossRef" href="#bib14">14</a>. This study aimed to determine the associations of liver lobe-based ADCs obtained using multiple b values with the presence and Child-Pugh class of cirrhosis.</p><p id="para220" class="elsevierStylePara elsevierViewall">Regarding the DWI protocol used in our study, b values of 0, 500, 800 and 1000 sec/mm<span class="elsevierStyleSup">2</span> were selected for liver lobe-based ADC calculations because a published study suggested that the sensitivity of the imaging sequence to water diffusion can change according to the b value <a class="elsevierStyleCrossRef" href="#bib15">15</a>. Specifically, diffusion information obtained from high b values (>500 sec/mm<span class="elsevierStyleSup">2</span>) could help to detect liver lesions, excluding perfusion effects, whereas that from very high b values (>1000 sec/mm<span class="elsevierStyleSup">2</span>) may reflect changes in tissue structure with greater sensitivity, although the signal to noise ratio of the image decreases with an increasing b value. As shown in this study, the liver lobe-based ADC measurements were reproducible, except for the ADC measurements in the left lobe in a few participants. The possible explanation for this result could be that the left lobe, especially the LLL, is more strongly affected by cardiac motion <a class="elsevierStyleCrossRef" href="#bib16">16</a>. To minimize the limitation of the reproducibility of ADC measurements in the left lobe in those few participants, we used the averaged ADC across the initial and repeated measurements as the final ADC for the statistical analysis.</p><p id="para230" class="elsevierStylePara elsevierViewall">As shown in our study, the liver lobe-based ADCs for b<span class="elsevierStyleInf">(0,500)</span>, b<span class="elsevierStyleInf">(0,800)</span> and b<span class="elsevierStyleInf">(0,1000)</span> inversely correlated with the Child-Pugh class of cirrhosis, except for the ADC for b<span class="elsevierStyleInf">(0,1000)</span> in the LML. The pathological mechanism may be that liver cirrhosis is associated with markedly increased extracellular constituents and collagen deposition in the space of Disse as the healthy liver progresses to cirrhosis, resulting in decreased total water content and impaired Brownian motion of water within the fibrotic liver. The tortuosity of the extracellular space and the decreased number of active fibroblasts restrict the apparent diffusion of water protons <a class="elsevierStyleCrossRef" href="#bib17">17</a>–<a class="elsevierStyleCrossRef" href="#bib19">19</a>. With an increasing Child-Pugh class of cirrhosis, the water diffusion in each liver lobe decreases further.</p><p id="para240" class="elsevierStylePara elsevierViewall">Regarding the comparison of ADCs between individual liver lobes, in cirrhotic patients, the ADCs for b<span class="elsevierStyleInf">(0,500)</span> and b<span class="elsevierStyleInf">(0,1000)</span> in the RL appeared to be lower than those in the LLL<span class="elsevierStyleInf">,</span> the LML and the CL, and the ADC for b<span class="elsevierStyleInf">(0,800)</span> in the RL appeared to be lower than that in the CL and the LLL. Our findings were inconsistent with previously published reports <a class="elsevierStyleCrossRef" href="#bib5">5</a>, which suggested that there was no significant difference in the ADCs between the right and left liver lobes. The possible explanation for these differences may be that the published study was conducted using a 1.5 T MR scanner but that our study was performed using a 3 T imaging system. Specifically, the measured ADC might be 15.9% higher at 3 T than at 1.5 T in the liver <a class="elsevierStyleCrossRef" href="#bib20">20</a>. The mechanism underlying our finding may be that hypertrophy of the caudate and left lateral lobes and atrophy of the right and left medial liver lobes occur as the healthy liver progresses to the stage of compensated cirrhosis, which restricts the apparent diffusion of water protons more remarkably in the RL than in any other liver lobe <a class="elsevierStyleCrossRef" href="#bib6">6</a>–<a class="elsevierStyleCrossRef" href="#bib8">8</a>.</p><p id="para250" class="elsevierStylePara elsevierViewall">Clinically, our findings suggested that the ADC for b<span class="elsevierStyleInf">(0,500)</span> in the LLL is the best indicator of the presence of cirrhosis among the ADCs of the LLL, the RL and the CL for b<span class="elsevierStyleInf">(0,500)</span>, the LML, the RL and the CL for b<span class="elsevierStyleInf">(0,800)</span>, and the CL for b<span class="elsevierStyleInf">(0,1000)</span>. The possible explanation for this result may be that the left liver lobe, especially the LLL, is the most frequently hypertrophic region as the healthy liver progresses to cirrhosis. This hypertrophy may be accompanied by liver cell regeneration to compensate for the reduced liver function, resulting in decreased total water content and restricted Brownian motion of water within this lobe <a class="elsevierStyleCrossRef" href="#bib21">21</a>,<a class="elsevierStyleCrossRef" href="#bib22">22</a>. Compared with the measurement of liver stiffness via MR elastography in a published report (23), the ADC for b<span class="elsevierStyleInf">(0,500)</span> in the LLL more accurately identifies the presence of cirrhosis because the AUC of stiffness measurements is lower than that of ADC measurements (0.919 vs. 0.989). Compared with published perfusion studies <a class="elsevierStyleCrossRef" href="#bib24">24</a>,<a class="elsevierStyleCrossRef" href="#bib25">25</a>, the ADC for b<span class="elsevierStyleInf">(0,500)</span> in the LLL more effectively determines the presence of cirrhosis than MR perfusion parameters.</p><p id="para260" class="elsevierStylePara elsevierViewall">For the first time, we found that the ADC for b<span class="elsevierStyleInf">(0,800)</span> in the RL better identified the Child-Pugh class of cirrhosis than the ADC for any other b value in any other liver lobe. The pathological mechanism may be that the right portal vein branch directly enters the parenchyma of the right liver lobe in cases of cirrhosis and that cirrhotic hepatic nodules cause compression and irregular stenosis of the intrahepatic branches of this portal vein, reducing flow through the right portal branch and resulting in the marked spreading of fibrous bands and the evident restriction of Brownian motion of water within the RL <a class="elsevierStyleCrossRef" href="#bib6">6</a>,<a class="elsevierStyleCrossRef" href="#bib26">26</a>.</p><p id="para270" class="elsevierStylePara elsevierViewall">Our study contains two inevitable limitations. First, our sample size was small; however, our study provides some useful information, specifically that liver lobe-based ADCs using multiple b values are associated with the presence and Child-Pugh class of cirrhosis. A larger number of samples will be included in our future study to confirm these findings. Second, the severity criterion used in this study was not the MELD score but rather the Child-Pugh class. The importance of these findings in clinical practice will be further explored using the MELD score.</p><p id="para280" class="elsevierStylePara elsevierViewall">In conclusion, our study revealed systematic differences in ADCs between liver lobes. The ADC for b<span class="elsevierStyleInf">(0,500)</span> in the LLL is recommended for determining the presence of liver cirrhosis, and the ADC for b<span class="elsevierStyleInf">(0,800)</span> in the RL is recommended for identifying the Child-Pugh class of cirrhosis. These findings may be helpful for understanding the association of liver lobe-based ADCs using multiple b values with the presence and Child-Pugh class of cirrhosis.</p></span><span id="cesec130" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle180">AUTHOR CONTRIBUTIONS</span><p id="para290" class="elsevierStylePara elsevierViewall">Tang HJ, Zhou L, Zhang XM, Liu J, Chen TW, Zeng NL, and Hu J contributed to the conception and design of the study; to the generation, collection, assembly, analysis and interpretation of the data; to the drafting and revision of the manuscript and approved the final version of the manuscript. Wang D, Li J, Huang YC, and Tang YL contributed to the generation, collection, assembly, analysis and interpretation of the data and approved the final version of the manuscript.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xpalclavsec1582287" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "MATERIALS AND METHODS" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Participant selection" ] 1 => array:2 [ "identificador" => "cesec40" "titulo" => "MR imaging protocol" ] 2 => array:2 [ "identificador" => "cesec50" "titulo" => "DWI data analysis" ] 3 => array:2 [ "identificador" => "cesec60" "titulo" => "Statistical analysis" ] ] ] 3 => array:3 [ "identificador" => "cesec70" "titulo" => "RESULTS" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "cesec80" "titulo" => "Reproducibility of ADC measurements" ] 1 => array:2 [ "identificador" => "cesec90" "titulo" => "Correlation of the liver lobe-based ADCs with the Child-Pugh class of cirrhosis" ] 2 => array:2 [ "identificador" => "cesec100" "titulo" => "Comparison of the ADCs between participants stratified by Child-Pugh class and between any two liver lobes in cirrhotic patients" ] 3 => array:2 [ "identificador" => "cesec110" "titulo" => "ROC analysis of ADCs for determining the Child-Pugh class of cirrhosis" ] ] ] 4 => array:2 [ "identificador" => "cesec120" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec130" "titulo" => "AUTHOR CONTRIBUTIONS" ] 6 => array:2 [ "identificador" => "xack639258" "titulo" => "ACKNOWLEDGMENTS" ] 7 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2015-02-04" "fechaAceptado" => "2015-04-30" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1582287" "palabras" => array:4 [ 0 => "Diffusion Magnetic Resonance Imaging" 1 => "Liver Cirrhosis" 2 => "Hepatitis B" 3 => "Chronic" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVE:</span><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">To determine the associations of liver lobe-based magnetic resonance diffusion-weighted imaging findings using multiple b values with the presence and Child-Pugh class of cirrhosis in patients with hepatitis B.</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHODS:</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">Seventy-four cirrhotic patients with hepatitis B and 25 healthy volunteers underwent diffusion-weighted imaging using b values of 0, 500, 800 and 1000 sec/mm<span class="elsevierStyleSup">2</span>. The apparent diffusion coefficients of individual liver lobes for b<span class="elsevierStyleInf">(0,500)</span>, b<span class="elsevierStyleInf">(0,800)</span> and b<span class="elsevierStyleInf">(0,1000)</span> were derived from the signal intensity averaged across images obtained using b values of 0 and 500 sec/mm<span class="elsevierStyleSup">2</span>, 0 and 800 sec/mm<span class="elsevierStyleSup">2</span>, or 0 and 1000 sec/mm<span class="elsevierStyleSup">2</span>, respectively, and were statistically analyzed to evaluate cirrhosis.</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS:</span><p id="spara90" class="elsevierStyleSimplePara elsevierViewall">The apparent diffusion coefficients for b<span class="elsevierStyleInf">(0,500)</span>, b<span class="elsevierStyleInf">(0,800)</span> and b<span class="elsevierStyleInf">(0,1000)</span> inversely correlated with the Child-Pugh class in the left lateral liver lobe, the left medial liver lobe, the right liver lobe and the caudate lobe (<span class="elsevierStyleItalic">r=</span>–0.35 to –0.60, all <span class="elsevierStyleItalic">p<</span>0.05), except for the apparent diffusion coefficient for b<span class="elsevierStyleInf">(0,1000)</span> in the left medial liver lobe (<span class="elsevierStyleItalic">r=</span>–0.17, <span class="elsevierStyleItalic">p></span>0.05). Among these parameters, the apparent diffusion coefficient for b<span class="elsevierStyleInf">(0,500)</span> in the left lateral liver lobe best differentiated normal from cirrhotic liver, with an area under the receiver operating characteristic curve of 0.989. The apparent diffusion coefficient for b<span class="elsevierStyleInf">(0,800)</span> in the right liver lobe best distinguished Child-Pugh class A from B–C and A–B from C, with areas under the receiver operating characteristic curve of 0.732 and 0.747, respectively.</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSION:</span><p id="spara100" class="elsevierStyleSimplePara elsevierViewall">Liver lobe-based apparent diffusion coefficients for b<span class="elsevierStyleInf">(0,500)</span> and b<span class="elsevierStyleInf">(0,800)</span> appear to be associated with the presence and Child-Pugh class of liver cirrhosis.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVE:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "METHODS:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "RESULTS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "CONCLUSION:" ] ] ] ] "multimedia" => array:6 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 595 "Ancho" => 742 "Tamanyo" => 66148 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">In a 47-year-old male with Child–Pugh Class C liver cirrhosis, three regions of interest were drawn in each of the left lateral liver lobe, the left medial liver lobe, the right liver lobe, and the caudate lobe for measurement using a b value of 0 sec/mm<span class="elsevierStyleSup">2</span> (A). These regions of interest were identically positioned on the corresponding liver lobes for the measurement of b<span class="elsevierStyleInf">(0,500)</span> (B), b<span class="elsevierStyleInf">(0,800)</span> (C) and b<span class="elsevierStyleInf">(0,1000)</span> (D) by the software to obtain the corresponding apparent diffusion coefficients.</p>" ] ] 1 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="tfn1" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Notes:</span> LLL, left lateral liver lobe; LML, left medial liver lobe; RL, right liver lobe; CL, caudate lobe; ADC, apparent diffusion coefficient; CV, coefficient of variation.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">CV, mean (range) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">No. of subjects with CV<10% \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">No. of subjects with CV≥10% \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleBold">ADC for b<span class="elsevierStyleInf">(0,500)</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LLL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">9.7% (5.6%–11.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LML \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">7.9% (2.1%–9.8%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>RL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">4.3% (3.5%–6.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>CL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">6.4% (3.5%–8.2%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleBold">ADC for b<span class="elsevierStyleInf">(0,800)</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LLL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">10.6% (5.9%–12.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">96 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LML \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">8.6% (1.9%–10.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">98 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>RL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">4.6% (3.8%–7.1%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>CL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">5.6% (3.9%–7.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleBold">ADC for b<span class="elsevierStyleInf">(0,1000)</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LLL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">9.8% (6.2%–11.5%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">97 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LML \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">7.3% (1.6%–9.4%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>RL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">4.8% (3.9%–8.3%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>CL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">5.8% (3.1%–8.9%) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">99 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Reproducibility of the apparent diffusion coefficient (×10<span class="elsevierStyleSup">-3</span> mm2/s) measurements in the enrolled participants.</p>" ] ] 2 => array:7 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="tfn2" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Notes:</span> LLL, left lateral liver lobe; LML, left medial liver lobe; RL, right liver lobe; CL, caudate lobe. * indicates a significant difference in the ADC between cirrhotic patients and healthy volunteers after Bonferroni correction (<span class="elsevierStyleItalic">p</span><0.005). a, b, and c indicate a significant difference in the ADC in the cirrhotic patients between the given liver lobe and the LLL, the LML and the CL, respectively, for the given b value after Bonferroni correction (<span class="elsevierStyleItalic">p</span><0.008)</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">b values (in s/mm<span class="elsevierStyleSup">2</span>) in the indicated liver lobe \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="bottom" scope="col">Healthy volunteers(n=25) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Cirrhotic patients(n=74) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="3" align="center" valign="middle" scope="col">Child-Pugh class of cirrhosis</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">A (n=23) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">B (n=27) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">C (n=24) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleBold">b<span class="elsevierStyleInf">(0,500)</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LLL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">2.78±0.51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.51±0.31* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.48±0.34* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.52±0.3* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.53±0.31* \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LML \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">2.1±0.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.7±0.48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.83±0.38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.82±0.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.45±0.38* \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>RL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.57±0.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.31±0.2*abc \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.37±0.22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.33±0.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.24±0.18* \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>CL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">2.2±0.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.52±0.36* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.62±0.44* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.57±0.35* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.37±0.25* \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleBold">b<span class="elsevierStyleInf">(0,800)</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LLL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.87±0.51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.44±0.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.62±0.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.42±0.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.32±0.26* \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LML \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.4±0.13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.18±0.13*ac \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.23±0.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.19±0.15* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.13±0.12* \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>RL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.61±0.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.34±0.28* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.49±0.35* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.31±0.25* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.15±0.14* \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>CL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.98±0.53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.3±0.28* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.41±0.28* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.4±0.3* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.2±0.22* \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleBold">b<span class="elsevierStyleInf">(0,1000)</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LLL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.75±0.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.42±0.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.58±0.44 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.37±0.22 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.35±0.56 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LML \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.41±0.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.34±0.27 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.37±0.25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.39±0.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.24±0.31 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>RL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.4±0.34 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.19±0.19abc \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.19±0.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.25±0.25 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.11±0.15* \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>CL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.89±0.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.44±0.34* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">1.65±0.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">1.42±0.34* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">1.31±0.28* \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Liver lobe-based ADCs (×10−3 mm2/s) in healthy volunteers and patients with cirrhosis of different Child-Pugh classes (mean±standard deviation).</p>" ] ] 3 => array:7 [ "identificador" => "tbl3" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="tfn3" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Notes:</span> ADC, apparent diffusion coefficient; LLL, left lateral liver lobe; LML, left medial liver lobe; RL, right liver lobe; CL, caudate lobe.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">Correlation index (<span class="elsevierStyleItalic">r</span>) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col"><span class="elsevierStyleItalic">p</span>-value \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleBold">ADC in the LLL</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>b<span class="elsevierStyleInf">(0,500)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">−0.47 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>b<span class="elsevierStyleInf">(0,800)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">−0.43 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>b<span class="elsevierStyleInf">(0,1000)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">−0.49 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleBold">ADC in the LML</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>b<span class="elsevierStyleInf">(0,500)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">−0.38 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>b<span class="elsevierStyleInf">(0,800)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">−0.53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>b<span class="elsevierStyleInf">(0,1000)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">−0.17 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.177 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleBold">ADC in the RL</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>b<span class="elsevierStyleInf">(0,500)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">−0.45 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>b<span class="elsevierStyleInf">(0,800)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">−0.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>b<span class="elsevierStyleInf">(0,1000)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">−0.35 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.004 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleBold">ADC in the CL</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>b<span class="elsevierStyleInf">(0,500)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">−0.59 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>b<span class="elsevierStyleInf">(0,800)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">−0.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>b<span class="elsevierStyleInf">(0,1000)</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">−0.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">Relationship between the apparent diffusion coefficient (×10−3 mm2/s) and the Child-Pugh class of cirrhosis.</p>" ] ] 4 => array:7 [ "identificador" => "tbl4" "etiqueta" => "Table 4" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="tfn4" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Notes</span>: LLL, left lateral liver lobe; LML, left medial liver lobe; RL, right liver lobe; CL, caudate lobe.* denotes significant differences in the apparent diffusion coefficients between the indicated groups after Bonferroni correction (<span class="elsevierStyleItalic">p<</span>0.013).</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">b values (s/mm<span class="elsevierStyleSup">2</span>) in the indicated liver lobe \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">Normal liver vs. Classes A–C \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">Class A vs. Classes B–C \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">Classes A–B vs. Class C \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleBold">b<span class="elsevierStyleInf">(0,500)</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LLL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.706 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.68 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LML \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.043 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.134 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.006* \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>RL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.001* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.134 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.083 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>CL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.258 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.043 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleBold">b<span class="elsevierStyleInf">(0,800)</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LLL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.093 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.095 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LML \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.113 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.065 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>RL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.009* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.003* \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>CL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"><0.001* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.158 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.015 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleBold">b<span class="elsevierStyleInf">(0,1000)</span></span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LLL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.05 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.036 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LML \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.644 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.511 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.056 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>RL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.014 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.428 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.057 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>CL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.001* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.013* \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.041 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara50" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleItalic">P</span>-values for the statistical comparisons of liver lobe-based apparent diffusion coefficients (×10−3 mm2/s) between groups of Child-Pugh classes of cirrhosis.</p>" ] ] 5 => array:7 [ "identificador" => "tbl5" "etiqueta" => "Table 5" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "leyenda" => "<p id="tfn5" class="elsevierStyleSimplePara elsevierViewall"><span class="elsevierStyleBold">Notes:</span> LLL, left lateral liver lobe; LML, left medial liver lobe; RL, right liver lobe; CL, caudate lobe; ADC, apparent diffusion coefficient; AUC, area under the receiver operating characteristic curve.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Cutoff value(×10−3 mm<span class="elsevierStyleSup">2</span>/s) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">Comparison \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="middle" scope="col">AUC \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">Sensitivity (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="middle" scope="col">Specificity (%) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="6" align="left" valign="middle"><span class="elsevierStyleBold">ADC forb<span class="elsevierStyleInf">(0,500)</span></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LLL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">2.04 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">Normal liver vs. cirrhosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.989 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">96.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>RL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.81 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">Normal liver vs. cirrhosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.795 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">64.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">66.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>CL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">Normal liver vs. cirrhosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.927 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">92.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">80 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LML \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">Classes A–B vs. Class C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.731 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">83.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">61.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="6" align="left" valign="middle"><span class="elsevierStyleBold">ADC for b<span class="elsevierStyleInf">(0,800)</span></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>LML \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.24 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">Normal liver vs. cirrhosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.872 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">92.9 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">68.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>RL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.40 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">Normal liver vs. cirrhosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.819 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">85.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">68.5 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>CL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.48 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">Normal liver vs. cirrhosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.874 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">100 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">66.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>RL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.32 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">Class A vs. Classes B–C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.732 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">66.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">66.7 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>RL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.21 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">Classes A–B vs. Class C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.747 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">72.2 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">61.1 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " colspan="6" align="left" valign="middle"><span class="elsevierStyleBold">ADC for b<span class="elsevierStyleInf">(0,1000)</span></span></td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>CL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">Normal liver vs. cirrhosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">0.783 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">71.5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">70 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle"><span class="elsevierStyleHsp" style=""></span>CL \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">1.53 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">Class A vs. Classes B–C \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="middle">0.721 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">66.7 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="middle">74.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara60" class="elsevierStyleSimplePara elsevierViewall">Receiver operating characteristic analysis of liver lobe-based apparent diffusion coefficients for determining the Child-Pugh class of cirrhosis.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:26 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Liver cirrhosis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ D Schuppan \n \t\t\t\t\t\t\t\t """ 1 => """ NH Afdhal \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(08)60383-9" "Revista" => array:7 [ "tituloSerie" => "Lancet" "fecha" => "2008" "volumen" => "371" "numero" => "9615" "paginaInicial" => "838" "paginaFinal" => "851" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18328931" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1016/S0140-6736(08)60383-9" "WWW" => array:1 [ "link" => "http://dx.doi.org/10.1016/S0140-6736(08)60383-9" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Progressive viral-induced cirrhosis: serial MR imaging findings and clinical correlation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ K Ito \n \t\t\t\t\t\t\t\t """ 1 => """ DG Mitchell \n \t\t\t\t\t\t\t\t """ 2 => """ HW Hann \n \t\t\t\t\t\t\t\t """ 3 => """ EK Outwater \n \t\t\t\t\t\t\t\t """ 4 => """ Y Kim \n \t\t\t\t\t\t\t\t """ 5 => """ T Fujita \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1148/radiology.207.3.9609897" "Revista" => array:7 [ "tituloSerie" => "Radiology" "fecha" => "1998" "volumen" => "207" "numero" => "3" "paginaInicial" => "729" "paginaFinal" => "735" "link" => array:1 [ 0 => array:2 [ "url" => 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array:4 [ "identificador" => "xack639258" "titulo" => "ACKNOWLEDGMENTS" "texto" => "<p id="para300" class="elsevierStylePara elsevierViewall">This work was supported by the National Natural Science Foundation of China (grant no. 81050033), the Key Projects in the Sichuan Province Science & Technology Pillar Program (grant no. 2011SZ0237), and the Science Foundation for Distinguished Young Scholars of Sichuan Province in China (grant no. 2010JQ0039).</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000007000000007/v1_202212011400/S1807593222013576/v1_202212011400/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000007000000007/v1_202212011400/S1807593222013576/v1_202212011400/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222013576?idApp=UINPBA00004N" ]
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