was read the article
array:24 [ "pii" => "S1807593222015411" "issn" => "18075932" "doi" => "10.1590/S1807-59322011000200029" "estado" => "S300" "fechaPublicacion" => "2011-01-01" "aid" => "1541" "copyright" => "CLINICS" "copyrightAnyo" => "2011" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "crp" "cita" => "Clinics. 2011;66:355-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S1807593222015423" "issn" => "18075932" "doi" => "10.1590/S1807-59322011000200030" "estado" => "S300" "fechaPublicacion" => "2011-01-01" "aid" => "1542" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "crp" "cita" => "Clinics. 2011;66:359-61" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CASE REPORT</span>" "titulo" => "Metanephric Adenoma: clinical, imaging, and Histological findings" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "359" "paginaFinal" => "361" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 448 "Ancho" => 598 "Tamanyo" => 47060 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">MRI - solid mass 5.2 cm in higher dimension located in right kidney with same hemorrhagic foci and no sign of perirenal invasion</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Fábio César Miranda Torricelli, Giovanni Scala Marchini, Rodrigo Sousa Madeira Campos, Antônio Otero Gil" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Fábio César Miranda" "apellidos" => "Torricelli" ] 1 => array:2 [ "nombre" => "Giovanni Scala" "apellidos" => "Marchini" ] 2 => array:2 [ "nombre" => "Rodrigo Sousa Madeira" "apellidos" => "Campos" ] 3 => array:2 [ "nombre" => "Antônio Otero" "apellidos" => "Gil" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222015423?idApp=UINPBA00004N" "url" => "/18075932/0000006600000002/v1_202212010821/S1807593222015423/v1_202212010821/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S180759322201540X" "issn" => "18075932" "doi" => "10.1590/S1807-59322011000200028" "estado" => "S300" "fechaPublicacion" => "2011-01-01" "aid" => "1540" "copyright" => "CLINICS" "documento" => "article" "crossmark" => 0 "licencia" => "https://creativecommons.org/licenses/by-nc/3.0/" "subdocumento" => "fla" "cita" => "Clinics. 2011;66:351-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">TECHNICAL NOTE</span>" "titulo" => "A new device to measure isometric strength in upper limbs: comparison between dominant and non-dominant limbs*" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "351" "paginaFinal" => "354" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 333 "Ancho" => 498 "Tamanyo" => 12935 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Device calibration data in vertical direction.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Paulo José Oliveira Cortez, José Elias Tomazini, Vitor E Valenti, José Rubens Correa, Erica E Valenti, Luiz Carlos de Abreu" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Paulo José Oliveira" "apellidos" => "Cortez" ] 1 => array:2 [ "nombre" => "José Elias" "apellidos" => "Tomazini" ] 2 => array:2 [ "nombre" => "Vitor E" "apellidos" => "Valenti" ] 3 => array:2 [ "nombre" => "José Rubens" "apellidos" => "Correa" ] 4 => array:2 [ "nombre" => "Erica E" "apellidos" => "Valenti" ] 5 => array:2 [ "nombre" => "Luiz Carlos" "apellidos" => "de Abreu" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S180759322201540X?idApp=UINPBA00004N" "url" => "/18075932/0000006600000002/v1_202212010821/S180759322201540X/v1_202212010821/en/main.assets" ] "en" => array:12 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CASE REPORT</span>" "titulo" => "Changing pattern of gonadotropins in a patient with an adrenal-androgen secreting tumor" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "355" "paginaFinal" => "357" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "José Antonio Miguel Marcondes, Cristiano RG Barcellos, Michelle P Rocha, Hélio Bisi" "autores" => array:4 [ 0 => array:4 [ "nombre" => "José Antonio Miguel" "apellidos" => "Marcondes" "email" => array:1 [ 0 => "marcondesmd@uol.com.br" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1-cln_66p355" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Cristiano RG" "apellidos" => "Barcellos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1-cln_66p355" ] ] ] 2 => array:3 [ "nombre" => "Michelle P" "apellidos" => "Rocha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "aff1-cln_66p355" ] ] ] 3 => array:3 [ "nombre" => "Hélio" "apellidos" => "Bisi" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">II</span>" "identificador" => "aff2-cln_66p355" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Endocrinology - Hospital das Clínicas de São Paulo, São Paulo, São Paulo, Brazil." "etiqueta" => "I" "identificador" => "aff1-cln_66p355" ] 1 => array:3 [ "entidad" => "Patologia - Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, Brazil." "etiqueta" => "II" "identificador" => "aff2-cln_66p355" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Tel.: 55 11 3159-0582" ] ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">There are a few studies about the secretion of gonadotropins in women. Acute testosterone infusion to normal women with and without testolactone inhibits LH sssecretion in a dose-dependent manner, without no effect on FSH secretion,<a class="elsevierStyleCrossRef" href="#bib1">1</a> while short-term administration of testosterone to normal women and eugonadal female-to-male transsexuals did not alter either gonadotropin levels, or affect the pulsatile secretion of LH.<a class="elsevierStyleCrossRef" href="#bib2">2</a></p><p id="para20" class="elsevierStylePara elsevierViewall">Regarding the effect of chronic hyperandrogenemia, in polycystic ovary syndrome a specific pattern of gonadotropins secretion has been described, with an increased concentration of basal LH and diminished FSH and with an increase in the frequency of LH pulses,<a class="elsevierStyleCrossRef" href="#bib3">3</a> while in adrenal or ovarian androgen-secreting tumors, gonadotropin levels vary from high,<a class="elsevierStyleCrossRefs" href="#bib4">4-6</a> normal for age<a class="elsevierStyleCrossRefs" href="#bib7">7-9</a> or suppressed.<a class="elsevierStyleCrossRefs" href="#bib7">7,10-11</a> The reason for the different gonadotropins pattern in androgen-secreting tumors is not clear. It is possible that the level of testosterone and the time exposure could influence the secretion of gonadotropins, as postulated by Spinder et al in transsexual<a class="elsevierStyleCrossRef" href="#bib2">2</a> and Bachelot <span class="elsevierStyleItalic">et al</span> in virilizing ovarian tumors.<a class="elsevierStyleCrossRef" href="#bib10">10</a></p><p id="para30" class="elsevierStylePara elsevierViewall">We report one patient with an adrenal androgen-secreting tumor (adrenal adenoma), where we document for the first time the transition of gonadotropin levels from normal to a suppressed state.</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">CASE REPORT</span><p id="para40" class="elsevierStylePara elsevierViewall">A 49-year-old female with a 4-year history of amenorrhea, excessive hair growth, hair loss, and deepening of the voice was admitted to the hospital. She had had normal menstrual cycling since menarche and denied hot flushes. At presentation she denied using any medication in the previous 6 months.</p><p id="para50" class="elsevierStylePara elsevierViewall">Physical examination revealed a normal weight (body mass index of 22.6 kg/m<span class="elsevierStyleSup">2</span>), parietal temporal baldness, and marked hirsutism. Her muscle mass was slightly enlarged. Blood pressure was 120 × 70 mmHg and heart rate was 76 beats/min. Breasts were hypoatrophic, without masses or galactorrhea. The abdomen was normal, and a pelvic examination revealed clitoromegaly. No anexial mass was palpable.</p><p id="para60" class="elsevierStylePara elsevierViewall">The initial laboratory investigation revealed a normal blood count. Liver and renal functions were within normal range. Basal hormone evaluation revealed an increased level of total testosterone with a level of DHEAS, estradiol and gonadotropins concentration normal for age (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>). Dexamethasone suppression test (0.5 mg, q.i.d. for 5 days) failed to suppress testosterone levels, whereas cortisol and DHEAS were suppressed normally. Cushing syndrome was ruled out by an overnight dexamethasone suppression test (1.0 mg - cortisol < 1.0 μg/dL).</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><p id="para70" class="elsevierStylePara elsevierViewall">Pelvic ultrasonography showed a right ovary of 6.8 cc and a left ovary of 5.8 cc, without nodules or cysts. Computed tomography of the abdomen disclosed a normal right adrenal gland. A solid nodule of 1.58 cm was seen on the left adrenal gland.</p><p id="para80" class="elsevierStylePara elsevierViewall">The patient refused further evaluation at that time, but appeared for a new evaluation 2 years later. Her physical examination was largely unchanged, except for progression of temporal balding. Basal hormone levels of total testosterone and estradiol did not change significantly (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>), while basal gonadotropin levels were suppressed in two separated samples. After acute GnRH administration, gonadotropin levels remained suppressed.</p><p id="para90" class="elsevierStylePara elsevierViewall">Pelvic ultrasonography showed a right ovary of 2.7 cc and a left ovary of 1.8 cc, without nodules or cysts. On Computed Tomography of the abdomen, the solid nodule on the left adrenal gland was unchanged.</p><p id="para100" class="elsevierStylePara elsevierViewall">The patient underwent a left adrenalectomy by laparoscopy. The tumor measured 4.5 × 4.0 × 2.5 cm and weighed 45 g. Macroscopically, the tumor was encapsulated with a thin, smooth, fibrous capsule. The tumor had a firm consistency with a variable brown to yellow colour on cross-section. There were no haemorrhages, necrosis or cystic degenerations. On microscopical examination, the tumor consisted of large polygonal cell with abundant eosinophilic cytoplasm, which showed focal peripherical basophilic granules and sometimes fine clear, vacuolation. Occasionally, there was some lipofuchsin pigment.</p><p id="para110" class="elsevierStylePara elsevierViewall">The patient was submitted to blood co<span class="elsevierStyleBold">l</span>lection 6 and 45 days and re-examined 60 days after the surgical procedure. Total testosterone and estradiol decreased while gonadotropins increase to postmenopausal range. She reported hot flushes and reduced libido, however male pattern baldness and hirsutism were unchanged.</p></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">DISCUSSION</span><p id="para120" class="elsevierStylePara elsevierViewall">The patient in this case study is a 49-year-old woman with a history of virilization for four years and an adrenal adenoma. Upon first examination, her basal gonadotropin levels were normal. The patient refused further examination or treatment, and was not seen in our out-patient clinic for two years. Upon her return, basal and GnRH-stimulated gonadotropin levels were suppressed, without significant change in total testosterone and estradiol levels. After surgery, gonadotropins increased to postmenopausal range. As gonadotropin levels in adrenal and ovarian androgen-secreting tumors have been described as variable,<a class="elsevierStyleCrossRefs" href="#bib4">4-11</a> this case led us to question whether the time of exposure of the gonadotrophic axis could be one factor that regulates gonadotropin levels in virilizing syndrome.</p><p id="para130" class="elsevierStylePara elsevierViewall">In patients with polycystic ovary syndrome, a state of chronic mild hyperandrogenemia, dynamic abnormalities of gonadotropins secretion are some of the most prominent findings.<a class="elsevierStyleCrossRef" href="#bib3">3</a> High basal LH levels and increased LH pulse amplitude have been described and may be related to elevated oestrogen levels<a class="elsevierStyleCrossRef" href="#bib3">3</a>. This same pattern of abnormality was also described in a patient with a luteinized thecoma of the ovary.<a class="elsevierStyleCrossRef" href="#bib12">12</a></p><p id="para140" class="elsevierStylePara elsevierViewall">In the other hand, there is not a specific pattern of gonadotropin levels in patients with virilizing tumors, except for inhibin-secreting ovarian tumors, where FSH is suppressed and LH can be normal or low.<a class="elsevierStyleCrossRef" href="#bib13">13</a> As a rule, gonadotropin levels in androgen-secreting ovarian tumors have been described as normal or suppressed.<a class="elsevierStyleCrossRefs" href="#bib7">7-11</a> Additionally, mean basal LH levels and LH pulse number and amplitude were lower in patients with ovarian tumors than compared to those with PCOS or normal women,<a class="elsevierStyleCrossRef" href="#bib10">10</a> suggesting different mechanisms of hypothalamic or pituitary feedback. In the same way, gonadotropin levels in patients with adrenal androgen-secreting tumors have also been reported as normal or suppressed, and significantly lower than in patients with non-tumors forms of hyperandrogenism.<a class="elsevierStyleCrossRef" href="#bib5">5</a></p><p id="para150" class="elsevierStylePara elsevierViewall">As long-term administration of androgens to women leads to virilizing effects, some of them irreversible, the effects of testosterone on gonadotropins secretion in normal women have been studied in female-to-male transsexual subjects.<a class="elsevierStyleCrossRef" href="#bib2">2</a> Administration of testosterone undecanoate for six-weeks to eugonadal transsexuals, or for three-months to agonadal transsexuals, did not affect the pulsatile secretion of LH or the basal levels of LH and FSH, despite the fact that this regimen resulted in a biologically effective androgen milieu. On the other hand, testosterone-esters administered to agonadal female-to-male transsexuals for at least six months, resulting in higher testosterone levels, were associated with a significant decrease in mean basal LH and FSH levels.<a class="elsevierStyleCrossRef" href="#bib2">2</a> It is interesting to note that while acute testosterone infusion inhibited LH secretion in a dose-dependent manner, without any effect on FSH secretion<a class="elsevierStyleCrossRef" href="#bib1">1</a>, long term administration was associated with a decrease in both LH and FSH levels<a class="elsevierStyleCrossRef" href="#bib2">2</a>. According to the authors, this could be a consequence of the duration of testosterone exposure.</p><p id="para160" class="elsevierStylePara elsevierViewall">To our knowledge, this is the first documented case of changing patterns of gonadotropins secretion observed in a patient with Virilizing Syndrome. This cannot be attributed to spontaneous fluctuation of gonadotropins secretion because responses to acute GnRH stimuli were blunted. In the same way, there was no change in the androgen milieu, as total testosterone and estradiol levels were unchanged. It could be that the gonadotropins pattern in virilizing states changes with time, as in female-to-male transsexuals.<a class="elsevierStyleCrossRef" href="#bib2">2</a> In fact, an inhibitory effect of testosterone and dihydrotestosterone on the LH response of GnRH in rat pituitary cells has been reported<a class="elsevierStyleCrossRef" href="#bib14">14</a>. According to this, when the tumor was removed and the testosterone level felt, there was a gradual release of the gonadotrophic axis, with increase of the gonadotropins levels to the status of menopause.</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSION</span><p id="para170" class="elsevierStylePara elsevierViewall">We report a patient who showed a changing pattern of gonadotropin levels that appeared to be time-dependent. As there were no changes in testosterone and estradiol levels, we postulate that exposure of the hypothalamus-pituitary to an androgen milieu over time can regulate gonadotropin levels in patients with androgen-secreting tumors.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:5 [ 0 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 1 => array:2 [ "identificador" => "cesec20" "titulo" => "CASE REPORT" ] 2 => array:2 [ "identificador" => "cesec30" "titulo" => "DISCUSSION" ] 3 => array:2 [ "identificador" => "cesec40" "titulo" => "CONCLUSION" ] 4 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">LH: luteinizing hormone, FSH: follicle stimulating hormone.</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " rowspan="2" align="left" valign="top" scope="col"></th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">Basal hormone levels</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " rowspan="2" align="center" valign="bottom" scope="col">After acute GnRHa<a class="elsevierStyleCrossRef" href="#tfn2-cln_66p355">1</a></th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " rowspan="2" align="center" valign="bottom" scope="col">6 days after surgery</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " rowspan="2" align="center" valign="bottom" scope="col">45 days after surgery</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">1<span class="elsevierStyleSup">st</span> interview \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col">2<span class="elsevierStyleSup">nd</span> interview<a class="elsevierStyleCrossRef" href="#tfn3-cln_66p355">2</a> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">LH (IU/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.6 - <0.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><0.6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">2.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">36.4 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">FSH (IU/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">5.4 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><1.0 - <1.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><1.0 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">15.1 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">48.2 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Estradiol (pg/mL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">62 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">47 - 51 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">42 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><13 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Testosterone (ng/dL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">945 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">637 - 732 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t">782 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><14 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t"><14 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">Progesterone (ng/mL) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"><0.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"><0.3 - <0.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black">- \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"><0.3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="char" valign="\n \t\t\t\t\ttop\n \t\t\t\t" style="border-bottom: 2px solid black"><0.3 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "tfn2-cln_66p355" "etiqueta" => "1" "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">After the administration of 200 μg by IV route.</p>" ] 1 => array:3 [ "identificador" => "tfn3-cln_66p355" "etiqueta" => "2" "nota" => "<p class="elsevierStyleNotepara" id="cenpara20">Two years later</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">Hormone levels under basal and dynamic condition and after surgery.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:14 [ 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"etal" => true "autores" => array:6 [ 0 => """ SL Minanni \n \t\t\t\t\t\t\t\t """ 1 => """ JA Marcondes \n \t\t\t\t\t\t\t\t """ 2 => """ BL Wajchenberg \n \t\t\t\t\t\t\t\t """ 3 => """ AM Cavaleiro \n \t\t\t\t\t\t\t\t """ 4 => """ MA Fortes \n \t\t\t\t\t\t\t\t """ 5 => """ MA Rego \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Fertil Steril" "fecha" => "1999" "volumen" => "71" "paginaInicial" => "83" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1016/S0015-0282(98)00514-7" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The value of the low-dose dexamethasone suppression test in the differential diagnosis of hyperandrogenism in women" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ GA Kaltsas \n \t\t\t\t\t\t\t\t """ 1 => """ AM Isidori \n 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\t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Clin Endocrinol" "fecha" => "1982" "volumen" => "17" "paginaInicial" => "67" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1111/j.1365-2265.1982.tb01628.x" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endocrine studies on ovarian androblastomas (Sertoli-Leydig tumors)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ M Munemura \n \t\t\t\t\t\t\t\t """ 1 => """ S Inoue \n \t\t\t\t\t\t\t\t """ 2 => """ R Himeno \n \t\t\t\t\t\t\t\t """ 3 => """ N Koyama \n \t\t\t\t\t\t\t\t """ 4 => """ J Mizumoto \n \t\t\t\t\t\t\t\t """ 5 => """ M Maeyama \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Endocrinol Investigation" "fecha" => "1984" "volumen" => 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array:2 [ "titulo" => "Activating mutation of the stimulatory G protein (gsp) as a putative cause of ovarian and testicular human stromal Leydig cell tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ MC Fragoso \n \t\t\t\t\t\t\t\t """ 1 => """ AC Latronico \n \t\t\t\t\t\t\t\t """ 2 => """ FM Carvalho \n \t\t\t\t\t\t\t\t """ 3 => """ MC Zerbini \n \t\t\t\t\t\t\t\t """ 4 => """ JA Marcondes \n \t\t\t\t\t\t\t\t """ 5 => """ LM Araujo \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Clin Endocrinol Metab" "fecha" => "1998" "volumen" => "83" "paginaInicial" => "8" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1210/jc.83.6.2074" ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A virilizing Leydig cell tumor of the ovary associated with stromal hyperplasia under gonadotropin control" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ JA Marcondes \n \t\t\t\t\t\t\t\t """ 1 => """ M Nery \n \t\t\t\t\t\t\t\t """ 2 => """ BB Mendonça \n \t\t\t\t\t\t\t\t """ 3 => """ SA Hayashida \n \t\t\t\t\t\t\t\t """ 4 => """ HW Halbe \n \t\t\t\t\t\t\t\t """ 5 => """ FM Carvalho \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Endocrinol Investigation" "fecha" => "1997" "volumen" => "20" "paginaInicial" => "9" ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Luteinizing hormone pulsatility in patients with major ovarian hyperandrogenism" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ A Bachelot \n \t\t\t\t\t\t\t\t """ 1 => """ K Laborde \n \t\t\t\t\t\t\t\t """ 2 => """ JL Bresson \n \t\t\t\t\t\t\t\t """ 3 => """ G Plu-Bureau \n \t\t\t\t\t\t\t\t """ 4 => """ A Raynaud \n \t\t\t\t\t\t\t\t """ 5 => """ X Bertagna \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "J Endocrinol Investigation" "fecha" => "2007" "volumen" => "30" "paginaInicial" => "46" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical features and hormonal characteristics in a case of ovarian arrhenoblastoma" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ P Tita \n \t\t\t\t\t\t\t\t """ 1 => """ A Spina \n \t\t\t\t\t\t\t\t """ 2 => """ G Briguglia \n \t\t\t\t\t\t\t\t """ 3 => """ A Magro \n \t\t\t\t\t\t\t\t """ 4 => """ D Gallo \n \t\t\t\t\t\t\t\t """ 5 => """ C Finocchiaro \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => 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"bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inhibin as a marker for granulosa-cell tumors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ RE Lappöhn \n \t\t\t\t\t\t\t\t """ 1 => """ HG Burger \n \t\t\t\t\t\t\t\t """ 2 => """ J Bouma \n \t\t\t\t\t\t\t\t """ 3 => """ M Bangah \n \t\t\t\t\t\t\t\t """ 4 => """ M Krans \n \t\t\t\t\t\t\t\t """ 5 => """ HW de Bruijn \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "N Engl J Med" "fecha" => "1989" "volumen" => "321" "paginaInicial" => "3" ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Androgen modulation of luteinizing hormone secretion by female rat gonadotropes" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ JL Turgeon \n \t\t\t\t\t\t\t\t """ 1 => """ DW Waring \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Endocrinology" "fecha" => "1999" "volumen" => "140" "paginaInicial" => "74" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "https://doi.org/10.1210/en.140.4.1767" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000006600000002/v1_202212010821/S1807593222015411/v1_202212010821/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006600000002/v1_202212010821/S1807593222015411/v1_202212010821/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222015411?idApp=UINPBA00004N" ]
Year/Month | Html | Total | |
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2023 July | 13 | 15 | 28 |
2023 June | 21 | 13 | 34 |
2023 May | 29 | 2 | 31 |
2023 April | 35 | 4 | 39 |
2023 March | 19 | 4 | 23 |
2023 February | 29 | 7 | 36 |
2023 January | 8 | 2 | 10 |
2022 December | 26 | 1 | 27 |