Changes in body weight, C-reactive protein, and total adiponectin in non-obese women after 12 months of a small-volume, home-based exercise program

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The FA map and the CC segmentation model of one healthy subject are illustrated in the top-left of the figure. The top-right image shows the sagittal 3D view of WM tracts derived from the segmented CC projected onto the FA map. The four bottom images show the superior view of the fibers projected in ascending axial slices. CC1: rostrum and genu, connects with the prefrontal and orbitofrontal cortices; CC2: anterior midbody, connects with the premotor and supplementary motor areas; CC3: posterior midbody, connects with the primary motor areas; CC4: isthmus, connects with the primary sensory area; CC5: splenium, connects with the parietal and temporal lobes and the visual cortex." ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carolina de Medeiros Rimkus, Thiago de Faria Junqueira, Dagoberto Callegaro, Maria Concepción García Otaduy, Claudia da Costa Leite" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Carolina" "apellidos" => "de Medeiros Rimkus" ] 1 => array:2 [ "nombre" => "Thiago" "apellidos" => "de Faria Junqueira" ] 2 => array:2 [ "nombre" => "Dagoberto" "apellidos" => "Callegaro" ] 3 => array:2 [ "nombre" => "Maria Concepción García" "apellidos" => "Otaduy" ] 4 => array:2 [ "nombre" => "Claudia" "apellidos" => "da Costa Leite" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222016453?idApp=UINPBA00004N" "url" => "/18075932/0000006800000008/v1_202212010718/S1807593222016453/v1_202212010718/en/main.assets" ] "en" => array:20 [ "idiomaDefecto" => true "cabecera" => "CLINICAL SCIENCE" "titulo" => "Changes in body weight, C-reactive protein, and total adiponectin in non-obese women after 12 months of a small-volume, home-based exercise program" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1121" "paginaFinal" => "1127" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Mauro Felippe Felix Mediano, Fabiana Alves Neves, Alessandra Cordeiro de Souza Rodrigues Cunha, Erica Patricia Garcia de Souza, Anibal Sanchez Moura, Rosely Sichieri" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Mauro Felippe Felix" "apellidos" => "Mediano" "email" => array:1 [ 0 => "mffmediano@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 1 => array:3 [ "nombre" => "Fabiana Alves" "apellidos" => "Neves" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "II" "identificador" => "aff2" ] ] ] 2 => array:3 [ "nombre" => "Alessandra Cordeiro" "apellidos" => "de Souza Rodrigues Cunha" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "II" "identificador" => "aff2" ] ] ] 3 => array:3 [ "nombre" => "Erica Patricia Garcia" "apellidos" => "de Souza" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "II" "identificador" => "aff2" ] ] ] 4 => array:3 [ "nombre" => "Anibal Sanchez" "apellidos" => "Moura" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "II" "identificador" => "aff2" ] ] ] 5 => array:3 [ "nombre" => "Rosely" "apellidos" => "Sichieri" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "I" "identificador" => "aff1" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "State University of Rio de Janeiro (UERJ), Institute of Social Medicine, Department of Epidemiology, Rio de Janeiro/RJ, Brazil" "etiqueta" => "I" "identificador" => "aff1" ] 1 => array:3 [ "entidad" => "State University of Rio de Janeiro (UERJ), Department of Physiological Sciences, Rio de Janeiro/RJ, Brazil" "etiqueta" => "II" "identificador" => "aff2" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Tel.: 55 21 2442-7661" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 719 "Ancho" => 787 "Tamanyo" => 21325 ] ] "descripcion" => array:1 [ "en" => "Estimated changes for CRP and adiponectin during the 12 months of follow-up by intervention groups." ] ] ] "textoCompleto" => "INTRODUCTIONObesity is considered to be a state of chronic, low-grade inflammation in which a greater production of pro-inflammatory cytokines overcomes the production of cytokines with anti-inflammatory properties. This condition seems to be involved in the pathogenesis of insulin resistance and vascular injury among obese individuals, predisposing those who gain weight to a greater risk of developing type 2 diabetes and cardiovascular diseases (<a class="elsevierStyleCrossRefs" href="#bib1">1–3</a>). C-reactive protein (CRP), which is secreted by liver cells, is a well-recognized clinical marker of inflammation that has been implicated in the pathogenesis of many chronic diseases. Large cross-sectional studies have shown that elevated serum levels of CRP are associated with increased body weight (<a class="elsevierStyleCrossRef" href="#bib4">4</a>,<a class="elsevierStyleCrossRef" href="#bib5">5</a>). In contrast, adiponectin is a protein secreted in abundance by adipose tissue in healthy subjects and possesses insulin-sensitizing, anti-inflammatory, and anti-atherogenic properties (<a class="elsevierStyleCrossRef" href="#bib6">6</a>). Adiponectin levels are reduced in conditions such as obesity, type 2 diabetes, metabolic syndrome, and ischemic heart disease (<a class="elsevierStyleCrossRef" href="#bib7">7</a>,<a class="elsevierStyleCrossRef" href="#bib8">8</a>).Lifestyle interventions focusing on the prevention of weight gain, including physical activity, are an important method of curbing the increasing prevalence of obesity and its complications (<a class="elsevierStyleCrossRef" href="#bib9">9</a>,<a class="elsevierStyleCrossRef" href="#bib10">10</a>). Although many studies have demonstrated the beneficial effects of exercise on anthropometric and metabolic parameters, the effects of exercise on the state of chronic, low-grade inflammation remain controversial (<a class="elsevierStyleCrossRefs" href="#bib11">11–14</a>). The results of cross-sectional studies indicate an important association between high levels of physical activity, low levels of CRP, and increased total adiponectin (<a class="elsevierStyleCrossRef" href="#bib15">15</a>,<a class="elsevierStyleCrossRef" href="#bib16">16</a>). A large longitudinal study of 3,042 individuals (1,524 men and 1,518 women), without any evidence of cardiovascular risk, evaluated the relationship between self-reported physical activity status and serum inflammatory markers and showed that participants devoted to high physical activity (>7 kcal/min expended) had a 29% lower concentration of C-reactive protein compared with those who were sedentary, even after adjusting for several confounders, such as gender, age, smoking habits, body mass index, total cholesterol, glucose, and blood pressure (<a class="elsevierStyleCrossRef" href="#bib17">17</a>). Moreover, a cross-sectional study conducted by Tsukinoki et al. (<a class="elsevierStyleCrossRef" href="#bib18">18</a>) investigating the associations between lifestyle factors (including physical activity levels) and plasma adiponectin levels among 202 Japanese male workers showed that even after adjustments for potential confounders, exercising two or more times per week significantly decreased the risk of low adiponectin levels (OR = 0.21; 95% CI = 0.06-0.74).In contrast, the results from clinical trials that examined the effects of exercise on low-grade inflammation are far from conclusive, with some studies showing the beneficial effects of exercise related to weight loss, others showing beneficial effects independently of weight loss, and still others showing no effect for exercise. It is noteworthy that most of these results were observed in obese individuals with high inflammatory levels at baseline (<a class="elsevierStyleCrossRefs" href="#bib19">19–23</a>). The degree of obesity may complicate the evaluation of exercise per se on inflammatory markers.An important aspect related to the practice of physical activity is the low adherence to formal programs (<a class="elsevierStyleCrossRef" href="#bib24">24</a>), which limits the efficacy of this intervention and highlights the need to identify strategies to promote an increased adherence to physical exercise. In this context, home-based exercise programs could emerge as an important and feasible strategy to prevent weight gain because it is low cost and less time-consuming . Some authors have shown positive effects of this intervention on different types of outcomes (<a class="elsevierStyleCrossRef" href="#bib25">25</a>,<a class="elsevierStyleCrossRef" href="#bib26">26</a>). Additionally, the prescribed amount of exercise may be of paramount importance to exercise adherence, with more demanding exercise programs associated with poorer adherence (<a class="elsevierStyleCrossRef" href="#bib27">27</a>).Therefore, we designed a study based on a small-changes approach (<a class="elsevierStyleCrossRef" href="#bib28">28</a>) in which a small volume and low-to-moderate intensity home-based exercise program improves exercise adherence and subsequently promote greater health benefits. The main results of the present trial related to weight change and lipids have already been published (<a class="elsevierStyleCrossRef" href="#bib29">29</a>). In the present analysis, we randomly selected a subgroup of blood specimens from our previous participants to evaluate the effects of small-volume, home-based exercise combined with slight caloric restriction on C-reactive protein and total adiponectin. Our study, conducted in a more homogeneous group of non-obese women, may aid us in evaluating the effect of exercise on inflammation.MATERIALS AND METHODSThe study population consisted of a sub-sample of a randomized clinical trial aimed at evaluating the effects of home-based exercise on weight change among non-obese women over a 12-month period. The full description and results of the effects of exercise intervention on anthropometric measures have been published elsewhere (<a class="elsevierStyleCrossRef" href="#bib29">29</a>). Briefly, 203 healthy women aged 25-45 years with a body mass index (BMI) of 23-29.9 kg/m2 and who were not pregnant or breastfeeding, had at least one child, and did not practice regular physical activity at least 6 months prior the study were randomly assigned to one of two groups for exercise intervention: the control (CG) or home-based (HB) exercise groups. All participants were fully informed about the objectives of the study and signed an informed consent form to participate. The study was approved by the Institutional Review Board of the State University of Rio de Janeiro.In the present analysis, we included a total of 54 women (CG = 28 and HB = 26) from whom blood samples were collected at baseline and 6 and 12 months of follow-up. The sample size required to detect a difference of 1.2 mg/L for C-reactive protein with a standard deviation of 0.97 mg/L, assuming a power of 90% and a significance level of 5%, was 30 women. Allowing for non-compliance in both groups, the estimated sample size was 50 (25 for each group).MeasurementsWeight, waist and hip circumferences, and inflammatory markers were measured at baseline and after 6 and 12 months of follow-up. Height was measured to the nearest 0.5 cm with a wall-mounted stadiometer, and body weight was measured using the same calibrated digital scale for all participants. Circumferences were determined with the participants standing and were measured at the largest girth of the hip and at the smallest girth of the waist. All measurements were performed in the morning, and blood samples were collected after a 10-hour fast. Aliquots of plasma and serum were isolated from the blood samples and frozen at -70 °C within 2 h of being drawn.The CRP concentration was determined using an enzyme immunoassay kit for humans according to the manufacturer's instructions (Human PCR Enzyme-linked Immunosorbent Assay Kit, USCN Life Science Inc., P.R., China). The kit had an assay sensitivity of 0.059 ng/mL and an intra-assay variation coefficient of 3.75%. Total serum adiponectin was determined using a commercial radioimmunoassay kit (Human Adiponectin RIA KIT I125 coated tube, Millipore Corporation, MA, USA) with an assay sensitivity of 1 ng/mL and an intra-assay variation coefficient of 8.54%.InterventionWomen allocated to the HB group were counseled by an exercise physiologist during the first appointment who explained in detail all the exercises to be practiced at home at least 3 times per week for 40 minutes per session (the booklet is available at <a href="http://www.nebin.org">www.nebin.org</a>). In the first week, women were advised to perform only one 20-minute session, increasing gradually (10 minutes/session/week) up to 40 minutes per session. The participants were asked to maintain an exercise intensity that allowed the participant to talk with any person next to them without breathlessness (low-to-moderate intensity) if necessary (30). The exercise sessions were divided into three parts: 1) a warm-up routine consisting of gentle body movements and stretching exercises (5 minutes); 2) an aerobic cycle performed in a circuit with continuous movements involving the large arm and leg muscles, as well as exercises using a ball and ropes, stair climbing, and standing up from a chair (30 minutes; balls and ropes were provided to the participants); and 3) a cool-down period during which the same initial stretching exercises were performed (5 minutes). Compliance with the exercise program was assessed once per month during the counseling sessions by having the women mark the days on which they exercised on a specific card printed with the days of the week. At this time, possible doubts related to the exercise program were clarified. The control group received only general information about the benefits of physical activity; no formal exercise prescription was provided to this group. Both groups received dietary counseling aimed at reducing their caloric intake by 100-300 calories per day, with a normal distribution of macro-nutrients (26-28% of energy as fat).Data analysisThe baseline characteristics of the two groups were compared using Student's t-test. Baseline correlations between anthropometric measures, CRP, and total adiponectin were estimated using the Spearman's correlation coefficient. Temporal changes in the anthropometric and inflammatory markers between groups were assessed by repeated random regression analysis using the procedure PROC MIXED in SAS (version 9.1, SAS Institute Inc, Cary, NC, USA). The analysis of anthropometric measures included BMI at baseline as a covariate, whereas the baseline measures were included for CRP and total adiponectin. Because of the non-linear weight change observed, the model incorporated a quadratic term (time×time) variable. The term of interest was time×treatment interaction, which estimates the rate of change in the outcomes. Statistical significance was set at p<0.05 for all analyses.RESULTSNo differences between the control and exercise groups were found in the baseline characteristics except for age, which showed a small difference (39.4±4.7 and 36.9±5.5, respectively; p = 0.08), and CRP, which showed a statistically significant difference (0.68±0.32 vs. 0.99±0.54, respectively; p = 0.01). As expected, the Spearman's correlation coefficient between anthropometric measurements, CRP, and total adiponectin at baseline showed that CRP was significantly associated with body weight (r = 0.30; p = 0.05) and BMI (r = 0.30; p = 0.04), whereas adiponectin was significantly inversely associated with the waist-to-hip ratio (r = -0.30; p = 0.03).During follow-up, the HB group showed a greater reduction in weight (-1.71 vs. -0.50; p = 0.03) and BMI (-0.67 vs. -0.20; p = 0.03) at six months. Thereafter, no differences between the groups were observed in these parameters (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>. For the inflammatory markers, a greater but non-statistically significant reduction was found for CRP in the HB group at six months (-0.03 vs. 0.15; p = 0.09), but this difference disappeared after adjusting for weight change (p = 0.30). Additionally, no differences were found for total adiponectin during the 12 months of follow-up (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>. The main changes in CRP and adiponectin during the 12 months of follow-up are shown in <a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>). The compliance rates with the exercise protocol during the follow-up period were 79 and 80% for months 6 and 12, respectively.<elsevierMultimedia ident="tbl1"></elsevierMultimedia><elsevierMultimedia ident="fig1"></elsevierMultimedia>DISCUSSIONThe present study demonstrated that a small volume of home-based exercise did not promote changes in either CRP or total adiponectin levels and highlights the importance of weight loss for the reduction of CRP, independently of physical activity, even among non-obese women. A greater reduction in CRP was observed among exercisers at 6 months of follow-up; however, this difference was not maintained when weight was regained after 6 months, and the borderline association disappeared when the analysis of CRP change at 6 months was adjusted for weight change.The importance of weight loss in CRP changes has been observed in many studies using different types of interventions, including physical activity (<a class="elsevierStyleCrossRef" href="#bib31">31</a>,<a class="elsevierStyleCrossRef" href="#bib32">32</a>). A randomized controlled trial conducted by Campbell et al. (<a class="elsevierStyleCrossRef" href="#bib33">33</a>) evaluated the effects of a year-long moderate-intensity aerobic exercise program (60-75% maximal HR, 40 minutes per session, 3 days per week) on CRP in 115 overweight or obese postmenopausal women. There was a statistically significant reduction in CRP among exercisers compared with controls (-0.24 vs. 0.29; p = 0.01), with better results obtained in those women who were obese at baseline and lost a greater amount of weight. In addition, only those exercisers who decreased their body fat by 2% or greater experienced a statistically significant reduction in CRP versus controls, suggesting that the exercise effect was primarily dependent on fat loss. In another randomized controlled trial, Church et al. (<a class="elsevierStyleCrossRef" href="#bib34">34</a>) observed no effect of exercise training without weight loss on the reduction of CRP when studying individuals with a BMI between 18.5 and 40 kg/m2 and elevated CRP at baseline (≥2.0 mg/L). The authors found a correlation between weight loss and reduction in CRP after 4 months of follow-up (r = 0.18; p<0.05). Moreover, Fisher et al. (<a class="elsevierStyleCrossRef" href="#bib35">35</a>) examined the effects of three different intervention groups (diet only, diet plus aerobic training, and diet plus resistance training) on CRP among premenopausal overweight women until they reached a BMI <25 kg/m2 and demonstrated a significant reduction in plasma CRP in all three intervention groups at the final follow-up, with no differences in CRP among the groups. This finding suggests that independently of the type of intervention, weight loss had a more profound impact on the reduction of CRP in overweight women than exercise per se.Despite the importance of weight change in improvements in CRP, some other studies have suggested that exercise could reduce CRP even in the absence of weight loss (<a class="elsevierStyleCrossRef" href="#bib36">36</a>,<a class="elsevierStyleCrossRef" href="#bib37">37</a>). For instance, Donges et al. (<a class="elsevierStyleCrossRef" href="#bib38">38</a>) conducted a clinical trial to investigate the effects of two different exercise interventions (resistance vs. aerobic exercise) on inflammatory markers during 10 weeks of follow-up and found an important reduction in CRP among the resistance exercise group even without changes in anthropometric measures, suggesting that reductions in inflammatory markers do not necessarily need to occur in the presence of weight loss or changes in body composition. In another study, Balducci et al. (<a class="elsevierStyleCrossRef" href="#bib39">39</a>) examined the effect of different exercise modalities on circulating levels of inflammatory markers, including CRP, among 82 individuals with metabolic syndrome (BMI 27-40 kg/m2) randomized into four groups: (1) sedentary controls, (2) those receiving counseling to perform low-intensity physical activities, (3) those performing prescribed and supervised high-intensity aerobic exercise, and (4) those performing high-intensity aerobic exercise plus resistance training. Although no significant changes in body weight, BMI, fat, or fat-free mass were observed in any of the groups, the levels of CRP decreased in all three exercise groups, with a greater reduction found in those who performed aerobic plus resistance exercise after 12 months of follow-up (54% reduction from baseline). A multiple regression analysis showed that maximum oxygen consumption, exercise volume, and the type of exercise were independent predictors of changes in CRP levels, and the authors suggested that factors related to the exercise prescription, such as type, volume, and intensity of the exercise, could contribute more to improvements in CRP than weight loss.Regarding the effects of exercise on adiponectin, the exercise intervention proposed in the present study did not change the levels of this cytokine during the 12 months of follow-up, although some other studies have demonstrated the positive effects of exercise (<a class="elsevierStyleCrossRef" href="#bib40">40</a>,<a class="elsevierStyleCrossRef" href="#bib41">41</a>). Kriketos et al. (<a class="elsevierStyleCrossRef" href="#bib42">42</a>) demonstrated a substantial increase in adiponectin levels (approximately 260%) after 10 weeks of aerobic exercises performed 4-5 days per week for 40 minutes per session at moderate intensity (55-70% VO2 max) in overweight individuals. This result was corroborated by the findings of Yoshida et al. (<a class="elsevierStyleCrossRef" href="#bib43">43</a>), revealing that an increase of 51% in adiponectin values was observed after 16 weeks of moderate-intensity exercise (60-80% of age-predicted maximal heart rate) performed 2-3 times per week for 60 minutes per session in normal-weight dyslipidemic individuals.A systematic review conducted by Simpson & Singh (<a class="elsevierStyleCrossRef" href="#bib21">21</a>), which included a total of eight randomized clinical trials evaluating the effects of exercise on adiponectin, showed a significant increase in plasma adiponectin ranging from 4.7-34.0% across studies, with an average increase of 16.3%, in response to different exercise modalities ranging from moderate to high intensities. The authors suggested that a minimum exercise volume of 90 minutes per week appeared to be necessary to achieve significant increases in adiponectin levels, and a possible dose-response effect of intensity has been observed in some studies (<a class="elsevierStyleCrossRef" href="#bib44">44</a>).Polak et al. (<a class="elsevierStyleCrossRef" href="#bib45">45</a>) examined the effects of low-intensity aerobic exercise (50% VO2 max) performed 5 days per week for 12 weeks among 25 obese sedentary premenopausal women and found no changes in adiponectin levels even in the presence of significant decreases in body weight and fat mass of 5.9 and 6.5% (p<0.001), respectively. Conversely, a study conducted by Moghadasi et al. (<a class="elsevierStyleCrossRef" href="#bib46">46</a>) demonstrated that a high-intensity endurance exercise program (75-80% VO2 max) performed 4 days a week for 12 weeks increased plasma adiponectin concentrations and gene expression of this cytokine in middle-aged men, reinforcing the importance of exercise intensity in inflammatory marker changes. However, it is important to note that, in the aforementioned study, a decrease in body weight was also found. The authors stated that exercise-induced changes in body weight and fat mass may play a pivotal role in improving plasma adiponectin, as previously shown by Marcell et al. (<a class="elsevierStyleCrossRef" href="#bib47">47</a>), who observed that a greater reduction in body weight and fat mass promoted greater improvements in adiponectin levels.The lack of a significant effect of exercise on CRP and adiponectin in the present study may indicate that our exercise protocol may have been insufficient in terms of the intensity and volume of training required to promote the physiological adaptations necessary to improve these markers. We could speculate that low-intensity exercises, such as those promoted by our study, need to lead to greater weight loss to reduce CRP and increase adiponectin, whereas higher intensity exercises seem to promote changes in inflammatory markers independently of weight loss. A systematic review conducted by Hamer (<a class="elsevierStyleCrossRef" href="#bib48">48</a>) concluded that both fitness and fatness are associated with systemic inflammatory status and that contributions of both may depend on several factors, such as age, gender, disease, and degree of inflammation at baseline. For example, exercise training is more effective among those individuals with high CRP and low adiponectin values (<a class="elsevierStyleCrossRef" href="#bib49">49</a>,<a class="elsevierStyleCrossRef" href="#bib50">50</a>), a situation that did not occur in our study because none of the participants showed high CRP values (>3.0 mg/L) (<a class="elsevierStyleCrossRef" href="#bib51">51</a>) and only one woman demonstrated low adiponectin levels (<4.0 mg/L) (<a class="elsevierStyleCrossRef" href="#bib52">52</a>) at baseline.Another important result of the present study corresponds to the baseline correlations between anthropometric measures, CRP, and total adiponectin. CRP was correlated with BMI and body weight, whereas adiponectin was associated with waist-to-hip ratio, a surrogate of central adiposity. These data suggest that total body fat is more important for the determination of CRP levels, whereas abdominal fat seems to be of central importance to adiponectin levels, confirming the findings demonstrated previously by other authors (<a class="elsevierStyleCrossRefs" href="#bib53">53–55</a>).The limitations of the present study include the lack of a gold standard measure of physical activity, although a self-reported diary shows good correlation with other methods, such as accelerometers and double-labeled water (<a class="elsevierStyleCrossRef" href="#bib56">56</a>,<a class="elsevierStyleCrossRef" href="#bib57">57</a>). In addition, the inflammatory marker used in the present study (CRP) can be highly variable and can be affected by numerous factors, such as the menstrual cycle, drugs, and alcohol consumption (<a class="elsevierStyleCrossRefs" href="#bib58">58–60</a>). Due to our small sample size, it was not possible to perform a sub-group analysis separating overweight from normal-weight women, shifting our findings toward the null hypothesis. Moreover, the subjects in the present study consisted only of females who were not obese, making it difficult to extrapolate the results to males and obese individuals.In conclusion, a small-volume, home-based exercise program did not promote changes in inflammatory markers after 6 and 12 months of follow-up among non-obese women. The greatest reduction in CRP observed among those women who performed exercise after six months was primarily caused by weight loss. Comparisons of the effects of different exercise modalities, as well as different volumes and intensities of training, on inflammatory markers and the relationship with weight change could be an important topic for future research.AUTHOR CONTRIBUTIONSMediano MF, Moura AS, and Sichieri R designed the study and participated in the statistical analysis and interpretation of the results. Mediano MF also performed the data collection, interviews, and statistical analysis, as well as wrote the first draft of the manuscript. Neves FA, Souza EP, and Cunha AC performed the biochemical analysis and helped in the statistical analysis. All authors were responsible for the critical review of the article. All authors read and approved the final version of the manuscript." "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xpalclavsec1581275" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "MATERIALS AND METHODS" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Measurements" ] 1 => array:2 [ "identificador" => "cesec40" "titulo" => "Intervention" ] 2 => array:2 [ "identificador" => "cesec50" "titulo" => "Data analysis" ] ] ] 3 => array:2 [ "identificador" => "cesec60" "titulo" => "RESULTS" ] 4 => array:2 [ "identificador" => "cesec70" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec80" "titulo" => "AUTHOR CONTRIBUTIONS" ] 6 => array:2 [ "identificador" => "xack638817" "titulo" => "ACKNOWLEDGMENTS" ] 7 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2013-02-07" "fechaAceptado" => "2013-04-09" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1581275" "palabras" => array:6 [ 0 => "Inflammation" 1 => "Obesity" 2 => "Overweight" 3 => "Prevention" 4 => "Physical Activity" 5 => "Exercise" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "OBJECTIVEOur objective was to evaluate the effects of small-volume, home-based exercise combined with slight caloric restriction on the inflammatory markers C-reactive protein and adiponectin. METHODSIn total, 54 women were randomly assigned to one of two groups for exercise intervention: the control or home-based exercise groups. Weight, waist and hip circumferences, and inflammatory markers were measured at baseline and after 6 and 12 months. Women allocated to the home-based exercise group received a booklet explaining the physical exercises to be practiced at home at least 3 times per week, 40 minutes per session, at low-to-moderate intensity. All participants received dietary counseling aimed at reducing caloric intake by 100-300 calories per day, with a normal distribution of macro-nutrients (26-28% of energy as fat). Clinicaltrials.gov: NCT01206413 RESULTSThe home-based exercise group showed a significantly greater reduction in weight and body mass index at six months, but no difference between groups was observed thereafter. With regard to the inflammatory markers, a greater but non-statistically significant reduction was found for C-reactive protein in the home-based exercise group at six months; however, this difference disappeared after adjusting for weight change. No differences in adiponectin were found at the 6- or 12-month follow-up. CONCLUSIONSmall-volume, home-based exercise did not promote changes in inflammatory markers independent of weight change." "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVE" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "METHODS" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "RESULTS" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "CONCLUSION" ] ] ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "No potential conflict of interest was reported." ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 719 "Ancho" => 787 "Tamanyo" => 21325 ] ] "descripcion" => array:1 [ "en" => "Estimated changes for CRP and adiponectin during the 12 months of follow-up by intervention groups." ] ] 1 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Baseline \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">p-value<a class="elsevierStyleCrossRef" href="#TFN01t01">a</a>) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="top" scope="col">6 months</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">p-value<a class="elsevierStyleCrossRef" href="#TFN02t01">b</a>) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="top" scope="col">12 months</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">p-value<a class="elsevierStyleCrossRef" href="#TFN02t01">b</a>) \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Mean(sd) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Mean(sd) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">‡ \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">Mean(sd) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col">‡ \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Body Weight (kg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Control \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">65.6 (6.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">64.4 (7.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-0.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">63.2 (5.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-1.50 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.16 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Intervention \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">68.6 (7.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">67.1 (9.5) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-1.71 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">65.7 (6.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-1.88 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Body Mass Index (kg/m2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Control \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">25.8 (1.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.08 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">25.5 (2.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-0.20 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">25.1 (2.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-0.57 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.18 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Intervention \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">26.7 (1.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">26.1 (2.1) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-0.67 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">25.8 (2.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-0.76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Waist Circumference (cm) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Control \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">80.5 (4.8) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.19 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">79.3 (5.6) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-0.74 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">79.3 (3.9) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-1.28 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.75 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Intervention \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">82.4 (5.4) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">79.8 (5.3) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-1.23 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">81.9 (3.2) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-1.68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Waist-to-hip Ratio \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Control \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.79 (0.05) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.68 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.79 (0.05) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.003 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.60 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.77 (0.02) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.009 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.17 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Intervention \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.79 (0.05) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.77 (0.05) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-0.0005 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.80 (0.05) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-0.004 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">C-reactive Protein (mg/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Control \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.68 (0.32) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.01 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.83 (0.38) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.09 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.80 (0.33) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.15 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.37 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Intervention \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.99 (0.54) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.96 (0.42) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-0.03 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">1.01 (0.38) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.007 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Adiponectin (mg/L) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Control \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">12.40 (6.40) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.76 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16.28 (24.90) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-1.33 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.94 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16.41 (15.21) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">3.58 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">0.93 \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Intervention \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">11.61 (9.98) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10.20 (4.87) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">-1.46 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">15.57 (13.30) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">3.75 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:2 [ 0 => array:3 [ "identificador" => "TFN01t01" "etiqueta" => "a" "nota" => "Student's t-test." ] 1 => array:3 [ "identificador" => "TFN02t01" "etiqueta" => "b" "nota" => "Repeated random regression analysis; the model included time, treatment, and the time×treatment interaction adjusted for baseline values (PROC MIXED, SAS 9.1)." ] ] ] "descripcion" => array:1 [ "en" => "Crude means (standard deviation) and adjusted changes from baseline (‡) for anthropometric measurements and inflammatory markers during the follow-up by intervention group (controls = 28 and home-based exercise = 26)." ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:60 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ 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"identificador" => "xack638817" "titulo" => "ACKNOWLEDGMENTS" "texto" => "Research related to this study was funded by grant 500404/2003-8 from the Brazilian National Research Council - CNPq." 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CLINICAL SCIENCE

Mauro Felippe Felix MedianoI,

Corresponding author

mffmediano@gmail.com

Tel.: 55 21 2442-7661

, Fabiana Alves NevesII, Alessandra Cordeiro de Souza Rodrigues CunhaII, Erica Patricia Garcia de SouzaII, Anibal Sanchez MouraII, Rosely SichieriI

I State University of Rio de Janeiro (UERJ), Institute of Social Medicine, Department of Epidemiology, Rio de Janeiro/RJ, Brazil

II State University of Rio de Janeiro (UERJ), Department of Physiological Sciences, Rio de Janeiro/RJ, Brazil

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the effects of exercise on the state of chronic&#44; low-grade inflammation remain controversial &#40;<a class="elsevierStyleCrossRefs" href="#bib11">11&#8211;14</a>&#41;&#46; The results of cross-sectional studies indicate an important association between high levels of physical activity&#44; low levels of CRP&#44; and increased total adiponectin &#40;<a class="elsevierStyleCrossRef" href="#bib15">15</a>&#44;<a class="elsevierStyleCrossRef" href="#bib16">16</a>&#41;&#46; A large longitudinal study of 3&#44;042 individuals &#40;1&#44;524 men and 1&#44;518 women&#41;&#44; without any evidence of cardiovascular risk&#44; evaluated the relationship between self-reported physical activity status and serum inflammatory markers and showed that participants devoted to high physical activity &#40;&#62;7 kcal&#47;min expended&#41; had a 29&#37; lower concentration of C-reactive protein compared with those who were sedentary&#44; even after adjusting for several confounders&#44; such as gender&#44; age&#44; smoking habits&#44; body mass index&#44; total cholesterol&#44; glucose&#44; and blood pressure &#40;<a class="elsevierStyleCrossRef" href="#bib17">17</a>&#41;&#46; Moreover&#44; a cross-sectional study conducted by Tsukinoki et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib18">18</a>&#41; investigating the associations between lifestyle factors &#40;including physical activity levels&#41; and plasma adiponectin levels among 202 Japanese male workers showed that even after adjustments for potential confounders&#44; exercising two or more times per week significantly decreased the risk of low adiponectin levels &#40;OR &#61; 0&#46;21&#59; 95&#37; CI &#61; 0&#46;06-0&#46;74&#41;&#46;</p><p id="para30" class="elsevierStylePara elsevierViewall">In contrast&#44; the results from clinical trials that examined the effects of exercise on low-grade inflammation are far from conclusive&#44; with some studies showing the beneficial effects of exercise related to weight loss&#44; others showing beneficial effects independently of weight loss&#44; and still others showing no effect for exercise&#46; It is noteworthy that most of these results were observed in obese individuals with high inflammatory levels at baseline &#40;<a class="elsevierStyleCrossRefs" href="#bib19">19&#8211;23</a>&#41;&#46; The degree of obesity may complicate the evaluation of exercise <span class="elsevierStyleItalic">per se</span> on inflammatory markers&#46;</p><p id="para40" class="elsevierStylePara elsevierViewall">An important aspect related to the practice of physical activity is the low adherence to formal programs &#40;<a class="elsevierStyleCrossRef" href="#bib24">24</a>&#41;&#44; which limits the efficacy of this intervention and highlights the need to identify strategies to promote an increased adherence to physical exercise&#46; In this context&#44; home-based exercise programs could emerge as an important and feasible strategy to prevent weight gain because it is low cost and less time-consuming &#46; Some authors have shown positive effects of this intervention on different types of outcomes &#40;<a class="elsevierStyleCrossRef" href="#bib25">25</a>&#44;<a class="elsevierStyleCrossRef" href="#bib26">26</a>&#41;&#46; Additionally&#44; the prescribed amount of exercise may be of paramount importance to exercise adherence&#44; with more demanding exercise programs associated with poorer adherence &#40;<a class="elsevierStyleCrossRef" href="#bib27">27</a>&#41;&#46;</p><p id="para50" class="elsevierStylePara elsevierViewall">Therefore&#44; we designed a study based on a small-changes approach &#40;<a class="elsevierStyleCrossRef" href="#bib28">28</a>&#41; in which a small volume and low-to-moderate intensity home-based exercise program improves exercise adherence and subsequently promote greater health benefits&#46; The main results of the present trial related to weight change and lipids have already been published &#40;<a class="elsevierStyleCrossRef" href="#bib29">29</a>&#41;&#46; In the present analysis&#44; we randomly selected a subgroup of blood specimens from our previous participants to evaluate the effects of small-volume&#44; home-based exercise combined with slight caloric restriction on C-reactive protein and total adiponectin&#46; Our study&#44; conducted in a more homogeneous group of non-obese women&#44; may aid us in evaluating the effect of exercise on inflammation&#46;</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">MATERIALS AND METHODS</span><p id="para60" class="elsevierStylePara elsevierViewall">The study population consisted of a sub-sample of a randomized clinical trial aimed at evaluating the effects of home-based exercise on weight change among non-obese women over a 12-month period&#46; The full description and results of the effects of exercise intervention on anthropometric measures have been published elsewhere &#40;<a class="elsevierStyleCrossRef" href="#bib29">29</a>&#41;&#46; Briefly&#44; 203 healthy women aged 25-45 years with a body mass index &#40;BMI&#41; of 23-29&#46;9 kg&#47;m<span class="elsevierStyleSup">2</span> and who were not pregnant or breastfeeding&#44; had at least one child&#44; and did not practice regular physical activity at least 6 months prior the study were randomly assigned to one of two groups for exercise intervention&#58; the control &#40;CG&#41; or home-based &#40;HB&#41; exercise groups&#46; All participants were fully informed about the objectives of the study and signed an informed consent form to participate&#46; The study was approved by the Institutional Review Board of the State University of Rio de Janeiro&#46;</p><p id="para70" class="elsevierStylePara elsevierViewall">In the present analysis&#44; we included a total of 54 women &#40;CG &#61; 28 and HB &#61; 26&#41; from whom blood samples were collected at baseline and 6 and 12 months of follow-up&#46; The sample size required to detect a difference of 1&#46;2 mg&#47;L for C-reactive protein with a standard deviation of 0&#46;97 mg&#47;L&#44; assuming a power of 90&#37; and a significance level of 5&#37;&#44; was 30 women&#46; Allowing for non-compliance in both groups&#44; the estimated sample size was 50 &#40;25 for each group&#41;&#46;</p><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">Measurements</span><p id="para80" class="elsevierStylePara elsevierViewall">Weight&#44; waist and hip circumferences&#44; and inflammatory markers were measured at baseline and after 6 and 12 months of follow-up&#46; Height was measured to the nearest 0&#46;5 cm with a wall-mounted stadiometer&#44; and body weight was measured using the same calibrated digital scale for all participants&#46; Circumferences were determined with the participants standing and were measured at the largest girth of the hip and at the smallest girth of the waist&#46; All measurements were performed in the morning&#44; and blood samples were collected after a 10-hour fast&#46; Aliquots of plasma and serum were isolated from the blood samples and frozen at -70 &#176;C within 2 h of being drawn&#46;</p><p id="para90" class="elsevierStylePara elsevierViewall">The CRP concentration was determined using an enzyme immunoassay kit for humans according to the manufacturer&#39;s instructions &#40;Human PCR Enzyme-linked Immunosorbent Assay Kit&#44; USCN Life Science Inc&#46;&#44; P&#46;R&#46;&#44; China&#41;&#46; The kit had an assay sensitivity of 0&#46;059 ng&#47;mL and an intra-assay variation coefficient of 3&#46;75&#37;&#46; Total serum adiponectin was determined using a commercial radioimmunoassay kit &#40;Human Adiponectin RIA KIT I125 coated tube&#44; Millipore Corporation&#44; MA&#44; USA&#41; with an assay sensitivity of 1 ng&#47;mL and an intra-assay variation coefficient of 8&#46;54&#37;&#46;</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">Intervention</span><p id="para100" class="elsevierStylePara elsevierViewall">Women allocated to the HB group were counseled by an exercise physiologist during the first appointment who explained in detail all the exercises to be practiced at home at least 3 times per week for 40 minutes per session &#40;the booklet is available at <a href="http://www.nebin.org">www&#46;nebin&#46;org</a>&#41;&#46; In the first week&#44; women were advised to perform only one 20-minute session&#44; increasing gradually &#40;10 minutes&#47;session&#47;week&#41; up to 40 minutes per session&#46; The participants were asked to maintain an exercise intensity that allowed the participant to talk with any person next to them without breathlessness &#40;low-to-moderate intensity&#41; if necessary &#40;30&#41;&#46; The exercise sessions were divided into three parts&#58; 1&#41; a warm-up routine consisting of gentle body movements and stretching exercises &#40;5 minutes&#41;&#59; 2&#41; an aerobic cycle performed in a circuit with continuous movements involving the large arm and leg muscles&#44; as well as exercises using a ball and ropes&#44; stair climbing&#44; and standing up from a chair &#40;30 minutes&#59; balls and ropes were provided to the participants&#41;&#59; and 3&#41; a cool-down period during which the same initial stretching exercises were performed &#40;5 minutes&#41;&#46; Compliance with the exercise program was assessed once per month during the counseling sessions by having the women mark the days on which they exercised on a specific card printed with the days of the week&#46; At this time&#44; possible doubts related to the exercise program were clarified&#46; The control group received only general information about the benefits of physical activity&#59; no formal exercise prescription was provided to this group&#46; Both groups received dietary counseling aimed at reducing their caloric intake by 100-300 calories per day&#44; with a normal distribution of macro-nutrients &#40;26-28&#37; of energy as fat&#41;&#46;</p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">Data analysis</span><p id="para110" class="elsevierStylePara elsevierViewall">The baseline characteristics of the two groups were compared using Student&#39;s t-test&#46; Baseline correlations between anthropometric measures&#44; CRP&#44; and total adiponectin were estimated using the Spearman&#39;s correlation coefficient&#46; Temporal changes in the anthropometric and inflammatory markers between groups were assessed by repeated random regression analysis using the procedure PROC MIXED in SAS &#40;version 9&#46;1&#44; SAS Institute Inc&#44; Cary&#44; NC&#44; USA&#41;&#46; The analysis of anthropometric measures included BMI at baseline as a covariate&#44; whereas the baseline measures were included for CRP and total adiponectin&#46; Because of the non-linear weight change observed&#44; the model incorporated a quadratic term &#40;time&#215;time&#41; variable&#46; The term of interest was time&#215;treatment interaction&#44; which estimates the rate of change in the outcomes&#46; Statistical significance was set at <span class="elsevierStyleItalic">p</span>&#60;0&#46;05 for all analyses&#46;</p></span></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">RESULTS</span><p id="para120" class="elsevierStylePara elsevierViewall">No differences between the control and exercise groups were found in the baseline characteristics except for age&#44; which showed a small difference &#40;39&#46;4&#177;4&#46;7 and 36&#46;9&#177;5&#46;5&#44; respectively&#59; <span class="elsevierStyleItalic">p</span> &#61; 0&#46;08&#41;&#44; and CRP&#44; which showed a statistically significant difference &#40;0&#46;68&#177;0&#46;32 <span class="elsevierStyleItalic">vs&#46;</span> 0&#46;99&#177;0&#46;54&#44; respectively&#59; <span class="elsevierStyleItalic">p</span> &#61; 0&#46;01&#41;&#46; As expected&#44; the Spearman&#39;s correlation coefficient between anthropometric measurements&#44; CRP&#44; and total adiponectin at baseline showed that CRP was significantly associated with body weight &#40;r &#61; 0&#46;30&#59; <span class="elsevierStyleItalic">p</span> &#61; 0&#46;05&#41; and BMI &#40;r &#61; 0&#46;30&#59; <span class="elsevierStyleItalic">p</span> &#61; 0&#46;04&#41;&#44; whereas adiponectin was significantly inversely associated with the waist-to-hip ratio &#40;r &#61; -0&#46;30&#59; <span class="elsevierStyleItalic">p</span> &#61; 0&#46;03&#41;&#46;</p><p id="para130" class="elsevierStylePara elsevierViewall">During follow-up&#44; the HB group showed a greater reduction in weight &#40;-1&#46;71 <span class="elsevierStyleItalic">vs&#46;</span> -0&#46;50&#59; <span class="elsevierStyleItalic">p</span> &#61; 0&#46;03&#41; and BMI &#40;-0&#46;67 <span class="elsevierStyleItalic">vs&#46;</span> -0&#46;20&#59; <span class="elsevierStyleItalic">p &#61;</span> 0&#46;03&#41; at six months&#46; Thereafter&#44; no differences between the groups were observed in these parameters &#40;<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#46; For the inflammatory markers&#44; a greater but non-statistically significant reduction was found for CRP in the HB group at six months &#40;-0&#46;03 <span class="elsevierStyleItalic">vs&#46;</span> 0&#46;15&#59; <span class="elsevierStyleItalic">p</span> &#61; 0&#46;09&#41;&#44; but this difference disappeared after adjusting for weight change &#40;<span class="elsevierStyleItalic">p</span> &#61; 0&#46;30&#41;&#46; Additionally&#44; no differences were found for total adiponectin during the 12 months of follow-up &#40;<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>&#46; The main changes in CRP and adiponectin during the 12 months of follow-up are shown in <a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>&#41;&#46; The compliance rates with the exercise protocol during the follow-up period were 79 and 80&#37; for months 6 and 12&#44; respectively&#46;</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><elsevierMultimedia ident="fig1"></elsevierMultimedia></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">DISCUSSION</span><p id="para140" class="elsevierStylePara elsevierViewall">The present study demonstrated that a small volume of home-based exercise did not promote changes in either CRP or total adiponectin levels and highlights the importance of weight loss for the reduction of CRP&#44; independently of physical activity&#44; even among non-obese women&#46; A greater reduction in CRP was observed among exercisers at 6 months of follow-up&#59; however&#44; this difference was not maintained when weight was regained after 6 months&#44; and the borderline association disappeared when the analysis of CRP change at 6 months was adjusted for weight change&#46;</p><p id="para150" class="elsevierStylePara elsevierViewall">The importance of weight loss in CRP changes has been observed in many studies using different types of interventions&#44; including physical activity &#40;<a class="elsevierStyleCrossRef" href="#bib31">31</a>&#44;<a class="elsevierStyleCrossRef" href="#bib32">32</a>&#41;&#46; A randomized controlled trial conducted by Campbell et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib33">33</a>&#41; evaluated the effects of a year-long moderate-intensity aerobic exercise program &#40;60-75&#37; maximal HR&#44; 40 minutes per session&#44; 3 days per week&#41; on CRP in 115 overweight or obese postmenopausal women&#46; There was a statistically significant reduction in CRP among exercisers compared with controls &#40;-0&#46;24 <span class="elsevierStyleItalic">vs&#46;</span> 0&#46;29&#59; <span class="elsevierStyleItalic">p &#61;</span> 0&#46;01&#41;&#44; with better results obtained in those women who were obese at baseline and lost a greater amount of weight&#46; In addition&#44; only those exercisers who decreased their body fat by 2&#37; or greater experienced a statistically significant reduction in CRP <span class="elsevierStyleItalic">versus</span> controls&#44; suggesting that the exercise effect was primarily dependent on fat loss&#46; In another randomized controlled trial&#44; Church et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib34">34</a>&#41; observed no effect of exercise training without weight loss on the reduction of CRP when studying individuals with a BMI between 18&#46;5 and 40 kg&#47;m<span class="elsevierStyleSup">2</span> and elevated CRP at baseline &#40;&#8805;2&#46;0 mg&#47;L&#41;&#46; The authors found a correlation between weight loss and reduction in CRP after 4 months of follow-up &#40;r &#61; 0&#46;18&#59; <span class="elsevierStyleItalic">p</span>&#60;0&#46;05&#41;&#46; Moreover&#44; Fisher et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib35">35</a>&#41; examined the effects of three different intervention groups &#40;diet only&#44; diet plus aerobic training&#44; and diet plus resistance training&#41; on CRP among premenopausal overweight women until they reached a BMI &#60;25 kg&#47;m<span class="elsevierStyleSup">2</span> and demonstrated a significant reduction in plasma CRP in all three intervention groups at the final follow-up&#44; with no differences in CRP among the groups&#46; This finding suggests that independently of the type of intervention&#44; weight loss had a more profound impact on the reduction of CRP in overweight women than exercise <span class="elsevierStyleItalic">per se</span>&#46;</p><p id="para160" class="elsevierStylePara elsevierViewall">Despite the importance of weight change in improvements in CRP&#44; some other studies have suggested that exercise could reduce CRP even in the absence of weight loss &#40;<a class="elsevierStyleCrossRef" href="#bib36">36</a>&#44;<a class="elsevierStyleCrossRef" href="#bib37">37</a>&#41;&#46; For instance&#44; Donges et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib38">38</a>&#41; conducted a clinical trial to investigate the effects of two different exercise interventions &#40;resistance <span class="elsevierStyleItalic">vs&#46;</span> aerobic exercise&#41; on inflammatory markers during 10 weeks of follow-up and found an important reduction in CRP among the resistance exercise group even without changes in anthropometric measures&#44; suggesting that reductions in inflammatory markers do not necessarily need to occur in the presence of weight loss or changes in body composition&#46; In another study&#44; Balducci et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib39">39</a>&#41; examined the effect of different exercise modalities on circulating levels of inflammatory markers&#44; including CRP&#44; among 82 individuals with metabolic syndrome &#40;BMI 27-40 kg&#47;m<span class="elsevierStyleSup">2</span>&#41; randomized into four groups&#58; &#40;1&#41; sedentary controls&#44; &#40;2&#41; those receiving counseling to perform low-intensity physical activities&#44; &#40;3&#41; those performing prescribed and supervised high-intensity aerobic exercise&#44; and &#40;4&#41; those performing high-intensity aerobic exercise plus resistance training&#46; Although no significant changes in body weight&#44; BMI&#44; fat&#44; or fat-free mass were observed in any of the groups&#44; the levels of CRP decreased in all three exercise groups&#44; with a greater reduction found in those who performed aerobic plus resistance exercise after 12 months of follow-up &#40;54&#37; reduction from baseline&#41;&#46; A multiple regression analysis showed that maximum oxygen consumption&#44; exercise volume&#44; and the type of exercise were independent predictors of changes in CRP levels&#44; and the authors suggested that factors related to the exercise prescription&#44; such as type&#44; volume&#44; and intensity of the exercise&#44; could contribute more to improvements in CRP than weight loss&#46;</p><p id="para170" class="elsevierStylePara elsevierViewall">Regarding the effects of exercise on adiponectin&#44; the exercise intervention proposed in the present study did not change the levels of this cytokine during the 12 months of follow-up&#44; although some other studies have demonstrated the positive effects of exercise &#40;<a class="elsevierStyleCrossRef" href="#bib40">40</a>&#44;<a class="elsevierStyleCrossRef" href="#bib41">41</a>&#41;&#46; Kriketos et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib42">42</a>&#41; demonstrated a substantial increase in adiponectin levels &#40;approximately 260&#37;&#41; after 10 weeks of aerobic exercises performed 4-5 days per week for 40 minutes per session at moderate intensity &#40;55-70&#37; VO<span class="elsevierStyleInf">2</span> max&#41; in overweight individuals&#46; This result was corroborated by the findings of Yoshida et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib43">43</a>&#41;&#44; revealing that an increase of 51&#37; in adiponectin values was observed after 16 weeks of moderate-intensity exercise &#40;60-80&#37; of age-predicted maximal heart rate&#41; performed 2-3 times per week for 60 minutes per session in normal-weight dyslipidemic individuals&#46;</p><p id="para180" class="elsevierStylePara elsevierViewall">A systematic review conducted by Simpson &#38; Singh &#40;<a class="elsevierStyleCrossRef" href="#bib21">21</a>&#41;&#44; which included a total of eight randomized clinical trials evaluating the effects of exercise on adiponectin&#44; showed a significant increase in plasma adiponectin ranging from 4&#46;7-34&#46;0&#37; across studies&#44; with an average increase of 16&#46;3&#37;&#44; in response to different exercise modalities ranging from moderate to high intensities&#46; The authors suggested that a minimum exercise volume of 90 minutes per week appeared to be necessary to achieve significant increases in adiponectin levels&#44; and a possible dose-response effect of intensity has been observed in some studies &#40;<a class="elsevierStyleCrossRef" href="#bib44">44</a>&#41;&#46;</p><p id="para190" class="elsevierStylePara elsevierViewall">Polak et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib45">45</a>&#41; examined the effects of low-intensity aerobic exercise &#40;50&#37; VO<span class="elsevierStyleInf">2</span> max&#41; performed 5 days per week for 12 weeks among 25 obese sedentary premenopausal women and found no changes in adiponectin levels even in the presence of significant decreases in body weight and fat mass of 5&#46;9 and 6&#46;5&#37; &#40;<span class="elsevierStyleItalic">p</span>&#60;0&#46;001&#41;&#44; respectively&#46; Conversely&#44; a study conducted by Moghadasi et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib46">46</a>&#41; demonstrated that a high-intensity endurance exercise program &#40;75-80&#37; VO<span class="elsevierStyleInf">2</span> max&#41; performed 4 days a week for 12 weeks increased plasma adiponectin concentrations and gene expression of this cytokine in middle-aged men&#44; reinforcing the importance of exercise intensity in inflammatory marker changes&#46; However&#44; it is important to note that&#44; in the aforementioned study&#44; a decrease in body weight was also found&#46; The authors stated that exercise-induced changes in body weight and fat mass may play a pivotal role in improving plasma adiponectin&#44; as previously shown by Marcell et al&#46; &#40;<a class="elsevierStyleCrossRef" href="#bib47">47</a>&#41;&#44; who observed that a greater reduction in body weight and fat mass promoted greater improvements in adiponectin levels&#46;</p><p id="para200" class="elsevierStylePara elsevierViewall">The lack of a significant effect of exercise on CRP and adiponectin in the present study may indicate that our exercise protocol may have been insufficient in terms of the intensity and volume of training required to promote the physiological adaptations necessary to improve these markers&#46; We could speculate that low-intensity exercises&#44; such as those promoted by our study&#44; need to lead to greater weight loss to reduce CRP and increase adiponectin&#44; whereas higher intensity exercises seem to promote changes in inflammatory markers independently of weight loss&#46; A systematic review conducted by Hamer &#40;<a class="elsevierStyleCrossRef" href="#bib48">48</a>&#41; concluded that both fitness and fatness are associated with systemic inflammatory status and that contributions of both may depend on several factors&#44; such as age&#44; gender&#44; disease&#44; and degree of inflammation at baseline&#46; For example&#44; exercise training is more effective among those individuals with high CRP and low adiponectin values &#40;<a class="elsevierStyleCrossRef" href="#bib49">49</a>&#44;<a class="elsevierStyleCrossRef" href="#bib50">50</a>&#41;&#44; a situation that did not occur in our study because none of the participants showed high CRP values &#40;&#62;3&#46;0 mg&#47;L&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib51">51</a>&#41; and only one woman demonstrated low adiponectin levels &#40;&#60;4&#46;0 mg&#47;L&#41; &#40;<a class="elsevierStyleCrossRef" href="#bib52">52</a>&#41; at baseline&#46;</p><p id="para210" class="elsevierStylePara elsevierViewall">Another important result of the present study corresponds to the baseline correlations between anthropometric measures&#44; CRP&#44; and total adiponectin&#46; CRP was correlated with BMI and body weight&#44; whereas adiponectin was associated with waist-to-hip ratio&#44; a surrogate of central adiposity&#46; These data suggest that total body fat is more important for the determination of CRP levels&#44; whereas abdominal fat seems to be of central importance to adiponectin levels&#44; confirming the findings demonstrated previously by other authors &#40;<a class="elsevierStyleCrossRefs" href="#bib53">53&#8211;55</a>&#41;&#46;</p><p id="para220" class="elsevierStylePara elsevierViewall">The limitations of the present study include the lack of a gold standard measure of physical activity&#44; although a self-reported diary shows good correlation with other methods&#44; such as accelerometers and double-labeled water &#40;<a class="elsevierStyleCrossRef" href="#bib56">56</a>&#44;<a class="elsevierStyleCrossRef" href="#bib57">57</a>&#41;&#46; In addition&#44; the inflammatory marker used in the present study &#40;CRP&#41; can be highly variable and can be affected by numerous factors&#44; such as the menstrual cycle&#44; drugs&#44; and alcohol consumption &#40;<a class="elsevierStyleCrossRefs" href="#bib58">58&#8211;60</a>&#41;&#46; Due to our small sample size&#44; it was not possible to perform a sub-group analysis separating overweight from normal-weight women&#44; shifting our findings toward the null hypothesis&#46; Moreover&#44; the subjects in the present study consisted only of females who were not obese&#44; making it difficult to extrapolate the results to males and obese individuals&#46;</p><p id="para230" class="elsevierStylePara elsevierViewall">In conclusion&#44; a small-volume&#44; home-based exercise program did not promote changes in inflammatory markers after 6 and 12 months of follow-up among non-obese women&#46; The greatest reduction in CRP observed among those women who performed exercise after six months was primarily caused by weight loss&#46; Comparisons of the effects of different exercise modalities&#44; as well as different volumes and intensities of training&#44; on inflammatory markers and the relationship with weight change could be an important topic for future research&#46;</p></span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">AUTHOR CONTRIBUTIONS</span><p id="para240" class="elsevierStylePara elsevierViewall">Mediano MF&#44; Moura AS&#44; and Sichieri R designed the study and participated in the statistical analysis and interpretation of the results&#46; Mediano MF also performed the data collection&#44; interviews&#44; and statistical analysis&#44; as well as wrote the first draft of the manuscript&#46; Neves FA&#44; Souza EP&#44; and Cunha AC performed the biochemical analysis and helped in the statistical analysis&#46; All authors were responsible for the critical review of the article&#46; All authors read and approved the final version of the manuscript&#46;</p></span></span>"
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          "titulo" => "DISCUSSION"
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          "titulo" => "AUTHOR CONTRIBUTIONS"
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    "fechaRecibido" => "2013-02-07"
    "fechaAceptado" => "2013-04-09"
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            0 => "Inflammation"
            1 => "Obesity"
            2 => "Overweight"
            3 => "Prevention"
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        "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVE</span><p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Our objective was to evaluate the effects of small-volume&#44; home-based exercise combined with slight caloric restriction on the inflammatory markers C-reactive protein and adiponectin&#46;</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHODS</span><p id="spara40" class="elsevierStyleSimplePara elsevierViewall">In total&#44; 54 women were randomly assigned to one of two groups for exercise intervention&#58; the control or home-based exercise groups&#46; Weight&#44; waist and hip circumferences&#44; and inflammatory markers were measured at baseline and after 6 and 12 months&#46; Women allocated to the home-based exercise group received a booklet explaining the physical exercises to be practiced at home at least 3 times per week&#44; 40 minutes per session&#44; at low-to-moderate intensity&#46; All participants received dietary counseling aimed at reducing caloric intake by 100-300 calories per day&#44; with a normal distribution of macro-nutrients &#40;26-28&#37; of energy as fat&#41;&#46; Clinicaltrials&#46;gov&#58; NCT01206413</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS</span><p id="spara50" class="elsevierStyleSimplePara elsevierViewall">The home-based exercise group showed a significantly greater reduction in weight and body mass index at six months&#44; but no difference between groups was observed thereafter&#46; With regard to the inflammatory markers&#44; a greater but non-statistically significant reduction was found for C-reactive protein in the home-based exercise group at six months&#59; however&#44; this difference disappeared after adjusting for weight change&#46; No differences in adiponectin were found at the 6- or 12-month follow-up&#46;</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSION</span><p id="spara60" class="elsevierStyleSimplePara elsevierViewall">Small-volume&#44; home-based exercise did not promote changes in inflammatory markers independent of weight change&#46;</p></span>"
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                  \t\t\t\t\tvoid\n
                  \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Baseline&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p</span>-value<a class="elsevierStyleCrossRef" href="#TFN01t01">a</a>&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="top" scope="col">6 months</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p</span>-value<a class="elsevierStyleCrossRef" href="#TFN02t01">b</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " colspan="2" align="center" valign="top" scope="col">12 months</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col"><span class="elsevierStyleItalic">p</span>-value<a class="elsevierStyleCrossRef" href="#TFN02t01">b</a>&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr><tr title="table-row"><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Mean&#40;sd&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Mean&#40;sd&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">&#8225;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">Mean&#40;sd&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">&#8225;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th><th class="td" title="\n
                  \t\t\t\t\ttable-head\n
                  \t\t\t\t  " align="center" valign="top" scope="col">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top"><span class="elsevierStyleBold">Body Weight &#40;kg&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">65&#46;6 &#40;6&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;12&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">64&#46;4 &#40;7&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-0&#46;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">63&#46;2 &#40;5&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-1&#46;50&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;16&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">68&#46;6 &#40;7&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">67&#46;1 &#40;9&#46;5&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-1&#46;71&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">65&#46;7 &#40;6&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-1&#46;88&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top"><span class="elsevierStyleBold">Body Mass Index &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">25&#46;8 &#40;1&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;08&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">25&#46;5 &#40;2&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-0&#46;20&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">25&#46;1 &#40;2&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-0&#46;57&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;18&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">26&#46;7 &#40;1&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">26&#46;1 &#40;2&#46;1&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-0&#46;67&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">25&#46;8 &#40;2&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-0&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top"><span class="elsevierStyleBold">Waist Circumference &#40;cm&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">80&#46;5 &#40;4&#46;8&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">79&#46;3 &#40;5&#46;6&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-0&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;56&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">79&#46;3 &#40;3&#46;9&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-1&#46;28&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">82&#46;4 &#40;5&#46;4&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">79&#46;8 &#40;5&#46;3&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-1&#46;23&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">81&#46;9 &#40;3&#46;2&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-1&#46;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top"><span class="elsevierStyleBold">Waist</span>-<span class="elsevierStyleBold">to</span>-<span class="elsevierStyleBold">hip Ratio</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;79 &#40;0&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;68&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;79 &#40;0&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;003&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;60&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;77 &#40;0&#46;02&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;17&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;79 &#40;0&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;77 &#40;0&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-0&#46;0005&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;80 &#40;0&#46;05&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-0&#46;004&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top"><span class="elsevierStyleBold">C-reactive Protein &#40;mg&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;68 &#40;0&#46;32&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;01&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;83 &#40;0&#46;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;09&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;80 &#40;0&#46;33&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;15&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;37&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;99 &#40;0&#46;54&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;96 &#40;0&#46;42&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-0&#46;03&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">1&#46;01 &#40;0&#46;38&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;007&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top"><span class="elsevierStyleBold">Adiponectin &#40;mg&#47;L&#41;</span>&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Control&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">12&#46;40 &#40;6&#46;40&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">16&#46;28 &#40;24&#46;90&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-1&#46;33&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;94&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">16&#46;41 &#40;15&#46;21&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">3&#46;58&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">0&#46;93&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">Intervention&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">11&#46;61 &#40;9&#46;98&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">10&#46;20 &#40;4&#46;87&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">-1&#46;46&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">15&#46;57 &#40;13&#46;30&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">3&#46;75&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="center" valign="top">&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr></tbody></table>
                  """
              ]
            ]
          ]
          "notaPie" => array:2 [
            0 => array:3 [
              "identificador" => "TFN01t01"
              "etiqueta" => "a"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">Student&#39;s t-test&#46;</p>"
            ]
            1 => array:3 [
              "identificador" => "TFN02t01"
              "etiqueta" => "b"
              "nota" => "<p class="elsevierStyleNotepara" id="cenpara20">Repeated random regression analysis&#59; the model included time&#44; treatment&#44; and the time&#215;treatment interaction adjusted for baseline values &#40;PROC MIXED&#44; SAS 9&#46;1&#41;&#46;</p>"
            ]
          ]
        ]
        "descripcion" => array:1 [
          "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">Crude means &#40;standard deviation&#41; and adjusted changes from baseline &#40;&#8225;&#41; for anthropometric measurements and inflammatory markers during the follow-up by intervention group &#40;controls &#61; 28 and home-based exercise &#61; 26&#41;&#46;</p>"
        ]
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "cebibsec10"
          "bibliografiaReferencia" => array:60 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Adiposity&#44; inflammation and hyperglycaemia in rural and urban Indian men&#58; Coronary Risk of Insulin Sensitivity in Indian Subjects &#40;CRISIS&#41; Study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => """
                              CS Yajnik \n
                              \t\t\t\t\t\t\t\t
                              """
                            1 => """
                              CV Joglekar \n
                              \t\t\t\t\t\t\t\t
                              """
                            2 => """
                              HG Lubree \n
                              \t\t\t\t\t\t\t\t
                              """
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                              """
                            3 => """
                              H Boeing \n
                              \t\t\t\t\t\t\t\t
                              """
                            4 => """
                              MB Pepys \n
                              \t\t\t\t\t\t\t\t
                              """
                            5 => """
                              W Koenig \n
                              \t\t\t\t\t\t\t\t
                              """
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        "titulo" => "ACKNOWLEDGMENTS"
        "texto" => "<p id="para250" class="elsevierStylePara elsevierViewall">Research related to this study was funded by grant 500404&#47;2003-8 from the Brazilian National Research Council - CNPq&#46;</p>"
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Article information

ISSN: 18075932
Original language: English

DOI:10.6061/clinics/2013(08)10

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