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"idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CLINICAL SCIENCE</span>" "titulo" => "Postural control in women with breast hypertrophy" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "757" "paginaFinal" => "760" ] ] "contieneResumen" => array:1 [ "en" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Alessandra Ferreira Barbosa, Gabriela Cristina Raggi, Cristina dos Santos Cardoso Sá, Márcio Paulino Costa, Jonas Eraldo de Lima, Clarice Tanaka" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Alessandra Ferreira" "apellidos" => "Barbosa" ] 1 => array:2 [ "nombre" => "Gabriela Cristina" "apellidos" => "Raggi" ] 2 => array:2 [ "nombre" => "Cristina" "apellidos" => "dos Santos Cardoso Sá" ] 3 => array:2 [ "nombre" => "Márcio Paulino" "apellidos" => "Costa" ] 4 => array:3 [ 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"apellidos" => "Stein" "email" => array:1 [ 0 => "steinanna87@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I,</span>" "identificador" => "af1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">II</span>" "identificador" => "af2" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "c1" ] ] ] 1 => array:3 [ "nombre" => "Silvia" "apellidos" => "Goldmeier" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "af1" ] ] ] 2 => array:3 [ "nombre" => "Sarah" "apellidos" => "Voltolini" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "af1" ] ] ] 3 => array:3 [ "nombre" => "Enio" "apellidos" => "Setogutti" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">III</span>" "identificador" => "af3" ] ] ] 4 => array:3 [ "nombre" => "Carlos" "apellidos" => "Feldman" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I,</span>" "identificador" => "af1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">III</span>" "identificador" => "af3" ] ] ] 5 => array:3 [ "nombre" => "Eduardo" "apellidos" => "Figueiredo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">IV</span>" "identificador" => "af4" ] ] ] 6 => array:3 [ "nombre" => "Renato" "apellidos" => "Eick" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I</span>" "identificador" => "af1" ] ] ] 7 => array:3 [ "nombre" => "Maria" "apellidos" => "Irigoyen" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">I,</span>" "identificador" => "af1" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">VI</span>" "identificador" => "af6" ] ] ] 8 => array:3 [ "nombre" => "Katya" "apellidos" => "Rigatto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">V</span>" "identificador" => "af5" ] ] ] ] "afiliaciones" => array:6 [ 0 => array:3 [ "entidad" => "Fundação Universitária de Cardiologia (IC/FUC), Instituto de Cardiologia do Rio Grande do Sul, Porto Alegre/RS, Brazil" "etiqueta" => "I" "identificador" => "af1" ] 1 => array:3 [ "entidad" => "Universidade Federal de São Paulo (UNIFESP), São Paulo, SP/Brazil" "etiqueta" => "II" "identificador" => "af2" ] 2 => array:3 [ "entidad" => "Serviço de Investigação Diagnóstica (SIDI), Porto Alegre, RS/Brazil" "etiqueta" => "III" "identificador" => "af3" ] 3 => array:3 [ "entidad" => "MR Res Latin America GE Healthcare, São Paulo, SP/Brazil" "etiqueta" => "IV" "identificador" => "af4" ] 4 => array:3 [ "entidad" => "Universidade Federal de Ciências da Saúde de Porto Alegre (UFCSPA), Departamento de Ciências Básicas da Saúde, Porto Alegre, RS/Brazil" "etiqueta" => "V" "identificador" => "af5" ] 5 => array:3 [ "entidad" => "Hospital das Clinicas da Faculdade de Medicina da Universidade de São Paulo, Instituto do Coração (InCor - USP), São Paulo, SP/Brazil" "etiqueta" => "VI" "identificador" => "af6" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "c1" "etiqueta" => "*" "correspondencia" => "Tel.: 55 51 3230-3757" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 618 "Ancho" => 618 "Tamanyo" => 96807 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">An R2* map superimposed on the anatomic image of the 9th echo. The lowest R2* was set to 7 Hz (blue), and the maximum R2* was set to 23 Hz (red). The intermediate values range from green and yellow to orange according to the color scale on the left.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle60">INTRODUCTION</span><p id="para10" class="elsevierStylePara elsevierViewall">Despite advances in renal dialysis, there has been no substantial change in the mortality rate of acute renal failure over the past three decades. In contrast, over the same period, acute myocardial infarction mortality has fallen dramatically, from approximately 50% to 6% (<a class="elsevierStyleCrossRef" href="#bib1">1</a>). In patients with end-stage renal disease, the mortality rate is growing because of the greater prevalence of hypertension and diabetes and the increased mean age of the population (<a class="elsevierStyleCrossRef" href="#bib2">2</a>). Indeed, in the United States and Australia, approximately 11% of adults have some degree of chronic kidney disease (<a class="elsevierStyleCrossRef" href="#bib3">3</a>). In addition, the strong association between chronic kidney disease and cardiovascular disease has led the National Kidney Foundation and the American Heart Association to recommend that all patients with cardiovascular disease also be screened for kidney disease (<a class="elsevierStyleCrossRef" href="#bib4">4</a>).</p><p id="para20" class="elsevierStylePara elsevierViewall">In cardiovascular disease, it is possible to precisely measure blood pressure, cholesterol or glucose concentration. However, it is still very difficult to identify early-stage renal injury, and current laboratory measurements are insufficient for making an early diagnosis. In addition, traditional imaging methods, although excellent for morphologic assessments, are limited in detecting premature renal functional alterations (<a class="elsevierStyleCrossRef" href="#bib5">5</a>). The sequence of events that reduces renal oxygenation leading to ischemia and/or kidney injury is still unknown (<a class="elsevierStyleCrossRef" href="#bib6">6</a>). Glomerular hyperfiltration (<a class="elsevierStyleCrossRef" href="#bib7">7</a>) or tubulointerstitial damage (<a class="elsevierStyleCrossRef" href="#bib8">8</a>) can cause progressive and irreversible renal failure, regardless of the initial insult. In fact, histological studies in human kidneys showed that tubulointerstitial oxygenation is modified before structural microvascular damage takes place. This observation indicates that morphological changes begin in a very early stage of kidney disease (<a class="elsevierStyleCrossRef" href="#bib9">9</a>). At this stage, it is not possible to diagnose renal pathology using the methods available. Thus, a method for detecting the early stages of renal functional changes would be very useful for the early treatment of renal disease. Unfortunately, renal biopsy is the only current method of confirm functional alteration (<a class="elsevierStyleCrossRef" href="#bib5">5</a>).</p><p id="para30" class="elsevierStylePara elsevierViewall">From the late 1980s, when Brezis (1991) (<a class="elsevierStyleCrossRef" href="#bib10">10</a>) inserted microelectrodes into the Sprague-Dawley rats renal parenchyma to demonstrate hypoxic changes during acute kidney injury, to the 1990s, when Prasad introduced blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) to the study of renal blood flow (<a class="elsevierStyleCrossRef" href="#bib11">11</a>), several different factors have been blamed for the slow progress of the prevention and treatment of acute or chronic renal failure.</p><p id="para40" class="elsevierStylePara elsevierViewall">There is no doubt that the renin angiotensin system (RAS) is useful to preserve peritubular capillary perfusion under normal situations (<a class="elsevierStyleCrossRef" href="#bib12">12</a>). However, when it is excessively stimulated, the RAS can induce renal hypoxia, reducing the efficiency of oxygen diffusion in renal tissue and provoking functional (<a class="elsevierStyleCrossRef" href="#bib13">13</a>) and structural changes, damage to the renal vasculature and fibrosis (<a class="elsevierStyleCrossRef" href="#bib14">14</a>).</p><p id="para50" class="elsevierStylePara elsevierViewall">In the present study, we measured the intra-renal effect of ACE inhibition on healthy subjects using a sensitive BOLD-MRI method that uses deoxygenated hemoglobin as an endogenous contrast agent. The ratio of oxyhemoglobin (diamagnetic) to deoxyhemoglobin (paramagnetic) is proportional to the partial oxygen pressure (pO<span class="elsevierStyleInf">2</span>). The BOLD signal is estimated using the transverse relaxation rate R2* (1/T<span class="elsevierStyleInf">2</span>*) and can be considered a sensitive indicator of tissue pO<span class="elsevierStyleInf">2</span>. However, an inverse ratio also exists; when this signal is increased, renal oxygenation is decreased, and vice versa (<a class="elsevierStyleCrossRef" href="#bib11">11</a>,<a class="elsevierStyleCrossRef" href="#bib15">15</a>).</p><p id="para60" class="elsevierStylePara elsevierViewall">Therefore, considering that angiotensin II (Ang II) reduces renal blood flow, (<a class="elsevierStyleCrossRefs" href="#bib16">16–17</a>) we hypothesized that partial ACE inhibition would increase the BOLD-MRI signal in renal tissue. The study of the mechanism underlying this putative process and the responses to ACE inhibition is of considerable importance. Understanding the mechanisms by which the kidney adapts to the effects of the RAS in healthy subjects will be useful for the early detection of renal disease and for the development of new therapies to decrease the progression of the disease and its consequences.</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle70">METHODS</span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle80">Subjects</span><p id="para70" class="elsevierStylePara elsevierViewall">The study was conducted under protocol (n° 4111/08), approved by the Ethics Committee of the <span class="elsevierStyleItalic">Instituto de Cardiologia do Rio Grande do Sul-Fundação Universitária de Cardiologia/</span>Brazil. After providing informed consent, five healthy female volunteers (50±5.3 years old) participated in the study. None of the subjects were taking any medications, and they were asked to abstain from food and water overnight. All measurements were performed in the late morning.</p><p id="para80" class="elsevierStylePara elsevierViewall">After a baseline BOLD-MRI acquisition, the subjects were given an oral ACE inhibitor (captopril 25 mg). Thirty minutes after captopril administration, without moving from the scanner, blood pressure was measured and a second BOLD acquisition was performed to detect possible changes in renal oxygenation. Data were collected by two radiologists and interpreted by a physician and a physiologist.</p></span><span id="cesec40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle90">MR Imaging Technique</span><p id="para90" class="elsevierStylePara elsevierViewall">Images were acquired using a 1.5T HDx instrument (Sigma, GE Healthcare, Waukesha, WI) and an 8-channel body coil.</p><p id="para100" class="elsevierStylePara elsevierViewall">Localizer images were performed in the axial and sagittal planes following the long axis of both kidneys, using the fast spoiled gradient echo (FSPGR) technique while the patients held their breath.</p><p id="para110" class="elsevierStylePara elsevierViewall">Oblique axial and coronal reference images were acquired to construct color maps following approximately the short and long axes of both kidneys using FSPGR with the following parameters: field of view (FOV) = 40 cm, matrix 256×128, slice thickness = 5 cm, slice gap 6 cm, 3 slices per plane in one breath hold, repetition time (RT) = 150 ms, echo time (ET = min full, angle degrees (FLIP) = 90, band width (rBW) = 62KHz, 1NEX. This sequence provides an excellent contrast between the cortex and the medulla and avoids the unnecessary use of contrast agents.</p><p id="para120" class="elsevierStylePara elsevierViewall">BOLD-sensitive images were acquired using the multiple echo FGRE sequence with the same geometrical parameters. The reference images considered the following parameters: TR = 60 ms, FLIP = 30, rBW = 60 KHz, 16 echoes from TE = 2.1 ms until 49.6 ms, an echo interval of 3.2 ms, 1 NEX.</p></span><span id="cesec50" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle100">BOLD imaging Data Processing</span><p id="para130" class="elsevierStylePara elsevierViewall">Bold image processing was performed using the Functool R2* module for R2*/T2* fitting, assuming single exponential decay without constant offset at AW4.3 (GE Healthcare).</p><p id="para140" class="elsevierStylePara elsevierViewall">For visualization and quantification, R2* parametric maps were generated for each slice (<a class="elsevierStyleCrossRef" href="#bib11">11</a>),. A Puh-Thallium color table was used because the data had a dynamic range with a minimum value set at 7.0/sec and a maximum value at 23/sec. The color ranged from blue to red from the minimum R2* to the maximum R2*, respectively. Green/yellow coloring represents intermediate R2*. When a position mismatch occurred due to a different breath hold state, anatomical fat-suppressed FSPGR images were used as transparent references over a parametric map or the original BOLD images.</p><p id="para150" class="elsevierStylePara elsevierViewall">Three slices were acquired, and the slice that provided the best differentiation between the cortex and the medulla and the minimum partial volume was selected for quantification. A total of six regions of interest (ROIs) with a pixel size of nine were used for each plane; three regions were positioned at the cortex and three were positioned at the medulla.</p><p id="para160" class="elsevierStylePara elsevierViewall">The ROIs were positioned at the cortex according to the anatomical reference image (light gray) and blue on the parametric map. The ROIs were positioned at the medulla using either the anatomical reference image (dark gray) or the parametric map that showed a green, yellow and red gradient (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1</a>). Areas with susceptibility artifacts, such as bowel gas, and areas with renal hilum vessels were avoided.</p><elsevierMultimedia ident="fig1"></elsevierMultimedia></span><span id="cesec60" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle110">Data analysis</span><p id="para170" class="elsevierStylePara elsevierViewall">The statistical significance was determined using an analysis of variance for three repeated measures (ANOVA) followed by the Tukey test (SPSS 12.0). The data are presented as the mean ± SD. <span class="elsevierStyleItalic">P</span><0.05 was considered statistically significant.</p></span></span><span id="cesec70" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle120">RESULTS</span><p id="para180" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a> summarizes the R2* measurements of the left and right kidney in the cortex and medulla before and after ACE inhibitor administration. Our results consistently indicate that moderate ACE inhibition reduced the R2* BOLD-MRI signal in the cortex and medulla and, therefore, increased renal blood flow. For all subjects, the R2* values were significantly higher in the medulla than in the cortex, and there was a significant difference between the baseline values and those obtained thirty minutes after ACE inhibitor administration (<a class="elsevierStyleCrossRef" href="#tbl1">Table 1</a>). No significant differences were observed for the values within subjects or between subjects for the cortex and medulla in the three measurements (data not shown).</p><elsevierMultimedia ident="tbl1"></elsevierMultimedia><p id="para190" class="elsevierStylePara elsevierViewall">The volunteers had an initial medial systolic blood pressure of 113±12 mmHg and a diastolic pressure of 76±5 mmHg. Thirty minutes after captopril administration, systolic but not diastolic blood pressure showed a modest but significant decrease. However, the systolic blood pressure did not significantly differ between 30 and 60 minutes after captopril administration (<a class="elsevierStyleCrossRef" href="#tbl2">Table 2</a>).</p><elsevierMultimedia ident="tbl2"></elsevierMultimedia><p id="para200" class="elsevierStylePara elsevierViewall">Hematocrit (37±3.6%) and hemoglobin (12±1.2 mEq/L) and the plasma concentrations of sodium (139±3.9 mEq/L), potassium (3.8±0.6 mEq/L) and creatinine (0.6±0.1 mEq/L) (n = 4) were measured in the clinical laboratory of the <span class="elsevierStyleItalic">Instituto de Cardiologia do Rio Grande do Sul</span>.</p></span><span id="cesec80" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle130">DISCUSSION</span><p id="para210" class="elsevierStylePara elsevierViewall">The main finding of this study is that the oral administration of a low dose of an ACE inhibitor allowed the early detection of an increase in renal cortical and medullar oxygenation using BOLD-MRI. This result is consistent with the very well-established property of Ang II to decrease renal perfusion and renal oxygenation (<a class="elsevierStyleCrossRefs" href="#bib16">16–17</a>). Ang II is known to be responsible for the majority of the physiological and pathological effects of RAS, and ACE inhibition reduces Ang II formation. Ang II inhibition has been highly successful in hypertension management and for reducing renal disease progression (<a class="elsevierStyleCrossRefs" href="#bib20">20–21</a>).</p><p id="para220" class="elsevierStylePara elsevierViewall">Renal hypoxia has long been considered important in the development of renal disease due to diabetes mellitus (<a class="elsevierStyleCrossRef" href="#bib22">22</a>). Ries et al. used the BOLD-MRI technique in an animal model and observed a significant decrease in oxygenation in the kidneys of diabetic patients compared to controls (<a class="elsevierStyleCrossRef" href="#bib23">23</a>). Several studies on the pathogenesis of essential hypertension have also shown that medullar blood flow reduction is one of the most important factors in the development of the renal disease (<a class="elsevierStyleCrossRef" href="#bib24">24</a>). However, a chronic infusion of a subpressor Ang II dose induces a long-term increase in BP. This effect could be associated with the afferent arteriolar reactivity to Ang II and might be present in the early stages of hypertension (<a class="elsevierStyleCrossRef" href="#bib25">25</a>). These findings and the fact that Ang II decreases renal oxygenation support the utility of BOLD-MRI for the study of the pathophysiology of hypertension (<a class="elsevierStyleCrossRefs" href="#bib26">26–27</a>).</p><p id="para230" class="elsevierStylePara elsevierViewall">Thus, efforts to measure functional renal oxygenation with the use of captopril, a renin Ang II axis inhibitor, provide data that is relevant to the prevention and treatment of renal diseases (<a class="elsevierStyleCrossRefs" href="#bib26">26–27</a>).</p><p id="para240" class="elsevierStylePara elsevierViewall">ACE inhibition and the subsequent reduction in Ang II plasma concentration (<a class="elsevierStyleCrossRef" href="#bib28">28</a>) most likely provoked renal arteriolar vasodilatation and increased renal blood flow and oxygenation. Thus, the decrease in R2* signal observed in the cortex and medulla likely occurred due to the increase in tissue pO<span class="elsevierStyleInf">2</span> (<a class="elsevierStyleCrossRef" href="#bib11">11</a>,<a class="elsevierStyleCrossRef" href="#bib15">15</a>) induced by moderate ACE inhibition. These findings support the idea that kidney oxygen content depends on both tubular sodium reabsorption and renal blood flow (<a class="elsevierStyleCrossRef" href="#bib29">29</a>) and reinforce the idea that R2* has an inverse correlation with oxygen content and blood flow (<a class="elsevierStyleCrossRef" href="#bib11">11</a>,<a class="elsevierStyleCrossRef" href="#bib30">30</a>).</p><p id="para250" class="elsevierStylePara elsevierViewall">The results obtained using renal BOLD-MRI in the presence of Ang II are most likely a consequence of reduced perfusion rather than of increased renal oxygen consumption (<a class="elsevierStyleCrossRef" href="#bib31">31</a>). Thus, the mechanism for improving oxygenation by Ang II blockade includes both hemodynamic changes and efficient oxygen usage (<a class="elsevierStyleCrossRef" href="#bib14">14</a>). These findings are consistent with our results, which indicated that the effects of the RAS were not exclusively associated with BP, although they were principally associated with renal perfusion.</p><p id="para260" class="elsevierStylePara elsevierViewall">The right and left kidneys did not have significantly different R2* values. It should also be emphasized that our control R2* values are very close to those found in the literature (<a class="elsevierStyleCrossRef" href="#bib11">11</a>,<a class="elsevierStyleCrossRef" href="#bib15">15</a>), for baseline measurements.</p><p id="para270" class="elsevierStylePara elsevierViewall">We recorded the BOLD signal after thirty minutes instead of 60 minutes because 25 mg of captopril decreased the systolic blood pressure (BP) equally at both time points. Thus, our protocol predicted the second BOLD signal acquisition after 30 minutes to avoid maintaining the subjects in a static position inside the scanner for an unnecessarily long period of time.</p><p id="para280" class="elsevierStylePara elsevierViewall">We believe that the decrease in systolic blood pressure observed in the first 30 minutes did not interfere with renal oxygenation. In support of this assumption, Schachinger recently demonstrated that vasoactive substances, such as noradrenalin and sodium nitroprusside, did not alter the renal BOLD signal, although they were able to provoke BP changes (<a class="elsevierStyleCrossRef" href="#bib31">31</a>). Ang II infusion is also known to decrease the renal BOLD signal as quickly as 10 s after the peripheral intravenous administration of an Ang II bolus. This is clearly faster than the arterial blood pressure response, suggesting that it may be related to reduced renal perfusion rather than to metabolic adjustment (<a class="elsevierStyleCrossRef" href="#bib31">31</a>).</p><p id="para290" class="elsevierStylePara elsevierViewall">Several studies have also demonstrated that, at lower concentrations, Ang II may cause greater vasoconstriction in the medulla than in the cortex. The authors hypothesize that this effect is likely related to the greater Ang II receptor density in the outer medulla (<a class="elsevierStyleCrossRefs" href="#bib36">36–37</a>). In fact, we also found that, under normal conditions, the oxygen content was significantly higher in the cortex than in the medulla. This result was maintained after ACE inhibition, indicating that the physiological balance between cortical and medullar circulation did not change after a moderate reduction of the Ang II in the blood stream.</p><p id="para300" class="elsevierStylePara elsevierViewall">Our results are consistent with those of many investigators who showed that BOLD detected a higher oxygen content in the cortex than in the medulla (<a class="elsevierStyleCrossRef" href="#bib11">11</a>,<a class="elsevierStyleCrossRef" href="#bib19">19</a>,<a class="elsevierStyleCrossRef" href="#bib34">34</a>,<a class="elsevierStyleCrossRef" href="#bib38">38</a>).</p><p id="para310" class="elsevierStylePara elsevierViewall">Thus, BOLD-MRI is a useful, non-invasive tool for defining basic physiological mechanisms, and it will contribute to a better understanding of regional oxygenation within the kidney (<a class="elsevierStyleCrossRef" href="#bib39">39</a>).</p><p id="para320" class="elsevierStylePara elsevierViewall">BOLD-MRI has opened an exciting new area for studying renal physiopathology and has created new possibilities for identifying the early stages of renal disease and perhaps new therapeutic targets (<a class="elsevierStyleCrossRef" href="#bib40">40</a>).</p><p id="para330" class="elsevierStylePara elsevierViewall">However, this study has several important limitations: 1- we did not include a placebo group; 2- the subject number was small; and 3- the study was conducted only in females. It is also important to note that subjects were not removed from the scanner prior to the second BOLD acquisition. Moreover, the conditions were the same during the data collection for all subjects, indicating that renal oxygenation was increased after captopril administration.</p><p id="para340" class="elsevierStylePara elsevierViewall">There is considerable interest in developing techniques that will enable physicians to identify and evaluate early changes in tissue function. BOLD-MRI may be a very useful technique for the early assessment of renal injuries in clinical practice. More studies should be conducted to confirm this hypothesis.</p></span><span id="cesec90" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle140">AUTHOR CONTRIBUTIONS</span><p id="para350" class="elsevierStylePara elsevierViewall">Stein A recorded data, participated in the analysis and interpretation of data, statistical analysis, and manuscript writing. Goldmeier S, Voltolini S, Setogutti E, Feldman C, and Figueiredo E recorded and interpreted data. Eick R analyzed and interpreted data and participated in manuscript writing. Rigatto K interpreted data and drafted and critically revised the manuscript. Irigoyen MC participated in the conception and design of the study, analyzed and interpreted data and drafted and critically revised the manuscript. All authors read and approved the final manuscript.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:8 [ 0 => array:2 [ "identificador" => "xpalclavsec1582827" "titulo" => "KEYWORDS" ] 1 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 2 => array:3 [ "identificador" => "cesec20" "titulo" => "METHODS" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "cesec30" "titulo" => "Subjects" ] 1 => array:2 [ "identificador" => "cesec40" "titulo" => "MR Imaging Technique" ] 2 => array:2 [ "identificador" => "cesec50" "titulo" => "BOLD imaging Data Processing" ] 3 => array:2 [ "identificador" => "cesec60" "titulo" => "Data analysis" ] ] ] 3 => array:2 [ "identificador" => "cesec70" "titulo" => "RESULTS" ] 4 => array:2 [ "identificador" => "cesec80" "titulo" => "DISCUSSION" ] 5 => array:2 [ "identificador" => "cesec90" "titulo" => "AUTHOR CONTRIBUTIONS" ] 6 => array:2 [ "identificador" => "xack639554" "titulo" => "ACKNOWLEDGMENTS" ] 7 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2012-02-27" "fechaAceptado" => "2012-03-20" "PalabrasClave" => array:1 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "KEYWORDS" "identificador" => "xpalclavsec1582827" "palabras" => array:5 [ 0 => "BOLD" 1 => "Renal Oxygenation" 2 => "Healthy Subjects" 3 => "Captopril" 4 => "Renin-Angiotensin System" ] ] ] ] "tieneResumen" => true "resumen" => array:1 [ "en" => array:2 [ "resumen" => "<span id="ceabs10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">OBJECTIVE:</span><p id="spara50" class="elsevierStyleSimplePara elsevierViewall">The association between renal hypoxia and the development of renal injury is well established. However, no adequate method currently exists to non-invasively measure functional changes in renal oxygenation in normal and injured patients.</p></span> <span id="ceabs20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">METHOD:</span><p id="spara60" class="elsevierStyleSimplePara elsevierViewall">R2* quantification was performed using renal blood oxygen level-dependent properties. Five healthy normotensive women (50±5.3 years) underwent magnetic resonance imaging in a 1.5T Signa Excite HDx scanner (GE Healthcare, Waukesha, WI). A multiple fast gradient-echo sequence was used to acquire R2*/T<span class="elsevierStyleInf">2</span>* images (sixteen echoes from 2.1 ms/slice to 49.6 ms/slice in a single breath hold per location). The images were post-processed to generate R2* maps for quantification. Data were recorded before and at 30 minutes after the oral administration of an angiotensin II-converting enzyme inhibitor (captopril, 25 mg). The results were compared using an ANOVA for repeated measurements (mean ± standard deviation) followed by the Tukey test. ClinicalTrials.gov: NCT01545479.</p></span> <span id="ceabs30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">RESULTS:</span><p id="spara70" class="elsevierStyleSimplePara elsevierViewall">A significant difference (<span class="elsevierStyleItalic">p</span><0.001) in renal oxygenation (R2*) was observed in the cortex and medulla before and after captopril administration: right kidney, cortex = 11.08±0.56ms, medulla = 17.21±1.47ms and cortex = 10.30±0.44ms, medulla = 16.06±1.74ms, respectively; and left kidney, cortex = 11.79±1.85ms, medulla = 17.03±0.88ms and cortex = 10.89±0.91ms, medulla = 16.43±1.49ms, respectively.</p></span> <span id="ceabs40" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle40">CONCLUSIONS:</span><p id="spara80" class="elsevierStyleSimplePara elsevierViewall">This result suggests that the technique efficiently measured alterations in renal blood oxygenation after angiotensin II-converting enzyme inhibition and that it may provide a new strategy for identifying the early stages of renal disease and perhaps new therapeutic targets.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "ceabs10" "titulo" => "OBJECTIVE:" ] 1 => array:2 [ "identificador" => "ceabs20" "titulo" => "METHOD:" ] 2 => array:2 [ "identificador" => "ceabs30" "titulo" => "RESULTS:" ] 3 => array:2 [ "identificador" => "ceabs40" "titulo" => "CONCLUSIONS:" ] ] ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara" id="cenpara30">No potential conflict of interest was reported.</p>" ] ] "multimedia" => array:3 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 618 "Ancho" => 618 "Tamanyo" => 96807 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">An R2* map superimposed on the anatomic image of the 9th echo. The lowest R2* was set to 7 Hz (blue), and the maximum R2* was set to 23 Hz (red). The intermediate values range from green and yellow to orange according to the color scale on the left.</p>" ] ] 1 => array:7 [ "identificador" => "tbl1" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:2 [ "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="top" scope="col">Cortex</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="top" scope="col">Medulla</th></tr><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Control \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">After captopril \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Control \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="center" valign="top" scope="col" style="border-bottom: 2px solid black">After captopril \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Right kidney \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">11.08 ± 0.56 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10.30 ± 0.44<span class="elsevierStyleSup">†</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">17.21 ± 1.47<a class="elsevierStyleCrossRef" href="#tfn1">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16.06 ± 1.74<a class="elsevierStyleCrossRef" href="#tfn1">*</a><span class="elsevierStyleSup">†</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">Left kidney \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">11.79 ± 1.85 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">10.89 ± 0.91<span class="elsevierStyleSup">†</span> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">17.03 ± 0.88<a class="elsevierStyleCrossRef" href="#tfn1">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">16.43 ± 1.49<a class="elsevierStyleCrossRef" href="#tfn1">*</a><span class="elsevierStyleSup">†</span> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tfn1" "etiqueta" => "∗" "nota" => "<p class="elsevierStyleNotepara" id="cenpara10"><span class="elsevierStyleItalic">p</span><0.001 <span class="elsevierStyleItalic">vs</span>. cortex (control and captopril), <span class="elsevierStyleSup">†</span><span class="elsevierStyleItalic">p</span><0.001 <span class="elsevierStyleItalic">vs.</span> control (medulla and cortex), ACE = angiotensin-converting enzyme.</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">R2<a class="elsevierStyleCrossRef" href="#tfn1">*</a> signal (ms) in the renal cortex and medulla in five healthy kidneys before (control) and at 30 minutes after the oral administration of an ACE inhibitor.</p>" ] ] 2 => array:7 [ "identificador" => "tbl2" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "tabla" => array:3 [ "leyenda" => "<p id="spara40" class="elsevierStyleSimplePara elsevierViewall">ACEi = angiotensin-converting enzyme inhibition; BP = Blood Pressure;</p>" "tablatextoimagen" => array:1 [ 0 => array:1 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="top" scope="col" style="border-bottom: 2px solid black">Time(minutes) \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">Before ACEi</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">15</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">30</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " colspan="2" align="center" valign="top" scope="col" style="border-bottom: 2px solid black">60</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="top">BP (mmHg) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Systolic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Diastolic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Systolic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Diastolic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Systolic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Diastolic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Systolic \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">Diastolic \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">113±12 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">76±5 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">108±13 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">70±6 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">105±8<a class="elsevierStyleCrossRef" href="#tfn3">*</a> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">69±3 \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">103±12** \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="center" valign="top">69±5 \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] ] ] "notaPie" => array:1 [ 0 => array:3 [ "identificador" => "tfn3" "etiqueta" => "∗" "nota" => "<p class="elsevierStyleNotepara" id="cenpara20"><span class="elsevierStyleItalic">p</span><0.05 and **<span class="elsevierStyleItalic">p</span><0.01 <span class="elsevierStyleItalic">vs.</span> systolic BP before ACEi</p>" ] ] ] "descripcion" => array:1 [ "en" => "<p id="spara30" class="elsevierStyleSimplePara elsevierViewall">Blood pressure measurements before and at 15, 30 and 60 minutes after the oral administration of an ACE inhibitor (n = 5).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:40 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute renal failure definitions and classification: time for change" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ RL Mehta \n \t\t\t\t\t\t\t\t """ 1 => """ GM Chertow \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/01.asn.0000079042.13465.1a" "Revista" => array:7 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2003" "volumen" => "14" "numero" => "8" "paginaInicial" => "2178" "paginaFinal" => "2187" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12874474" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Ischemic nephropathy: clinical characteristics and treatment" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ JM Alcazar \n \t\t\t\t\t\t\t\t """ 1 => """ JL Rodicio \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1053/ajkd.2000.19077" "Revista" => array:7 [ "tituloSerie" => "Am J Kidney Dis" "fecha" => "2000" "volumen" => "36" "numero" => "5" "paginaInicial" => "883" "paginaFinal" => "893" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11054344" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of chronic kidney disease: a global challenge" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ AK Bello \n \t\t\t\t\t\t\t\t """ 1 => """ E Nwankwo \n \t\t\t\t\t\t\t\t """ 2 => """ AM El Nahas \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Kidney Int Suppl" "fecha" => "2005" "numero" => "98" "paginaInicial" => "S11" "paginaFinal" => "S17" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Detection of chronic kidney disease in patients with or at increased risk of cardiovascular disease: a science advisory from the American Heart Association Kidney and Cardiovascular Disease Council; the Councils on High Blood Pressure Research, Cardiovascular Disease in the Young, and Epidemiology and Prevention; and the Quality of Care and Outcomes Research Interdisciplinary Working Group: Developed in Collaboration With the National Kidney Foundation" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ FC Brosius 3rd \n \t\t\t\t\t\t\t\t """ 1 => """ TH Hostetter \n \t\t\t\t\t\t\t\t """ 2 => """ E Kelepouris \n \t\t\t\t\t\t\t\t """ 3 => """ MM Mitsnefes \n \t\t\t\t\t\t\t\t """ 4 => """ SM Moe \n \t\t\t\t\t\t\t\t """ 5 => """ MA Moore \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/CIRCULATIONAHA.106.177321" "Revista" => array:7 [ "tituloSerie" => "Hypertension" "fecha" => "2006" "volumen" => "48" "numero" => "4" "paginaInicial" => "751" "paginaFinal" => "755" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16990648" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The role of diuretic renography in the evaluation of obstructed hydronephrosis after pediatric pyeloplasty" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ TM Wang \n \t\t\t\t\t\t\t\t """ 1 => """ PL Chang \n \t\t\t\t\t\t\t\t """ 2 => """ PF Kao \n \t\t\t\t\t\t\t\t """ 3 => """ ML Hsieh \n \t\t\t\t\t\t\t\t """ 4 => """ ST Huang \n \t\t\t\t\t\t\t\t """ 5 => """ KH Tsui \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Chang Gung Med J" "fecha" => "2004" "volumen" => "27" "numero" => "5" "paginaInicial" => "344" "paginaFinal" => "350" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15366810" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The use of magnetic resonance to evaluate tissue oxygenation in renal artery stenosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ SC Textor \n \t\t\t\t\t\t\t\t """ 1 => """ JF Glockner \n \t\t\t\t\t\t\t\t """ 2 => """ LO Lerman \n \t\t\t\t\t\t\t\t """ 3 => """ S Misra \n \t\t\t\t\t\t\t\t """ 4 => """ MA McKusick \n \t\t\t\t\t\t\t\t """ 5 => """ SJ Riederer \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1681/ASN.2007040420" "Revista" => array:7 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2008" "volumen" => "19" "numero" => "4" "paginaInicial" => "780" "paginaFinal" => "788" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18287564" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Glomerular response to renal injury" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ BM Brenner \n \t\t\t\t\t\t\t\t """ 1 => """ RC Goldszer \n \t\t\t\t\t\t\t\t """ 2 => """ TH Hostetter \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1159/000407066" "Revista" => array:6 [ "tituloSerie" => "Contrib Nephrol" "fecha" => "1982" "volumen" => "33" "paginaInicial" => "48" "paginaFinal" => "66" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6749423" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mechanisms of tubulointerstitial injury in the kidney: final common pathways to end-stage renal failure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ M Nangaku \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2169/internalmedicine.43.9" "Revista" => array:7 [ "tituloSerie" => "Intern Med" "fecha" => "2004" "volumen" => "43" "numero" => "1" "paginaInicial" => "9" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14964574" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ M Nangaku \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1681/ASN.2005070757" "Revista" => array:7 [ "tituloSerie" => "J Am Soc Nephrol" "fecha" => "2006" "volumen" => "17" "numero" => "1" "paginaInicial" => "17" "paginaFinal" => "25" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16291837" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Early renal medullary hypoxic injury from radiocontrast and indomethacin" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ SN Heyman \n \t\t\t\t\t\t\t\t """ 1 => """ M Brezis \n \t\t\t\t\t\t\t\t """ 2 => """ FH Epstein \n \t\t\t\t\t\t\t\t """ 3 => """ K Spokes \n \t\t\t\t\t\t\t\t """ 4 => """ P Silva \n \t\t\t\t\t\t\t\t """ 5 => """ S Rosen \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/ki.1991.255" "Revista" => array:7 [ "tituloSerie" => "Kidney Int" "fecha" => "1991" "volumen" => "40" "numero" => "4" "paginaInicial" => "632" "paginaFinal" => "642" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1745012" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Noninvasive evaluation of intrarenal oxygenation with BOLD MRI" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ PV Prasad \n \t\t\t\t\t\t\t\t """ 1 => """ RR Edelman \n \t\t\t\t\t\t\t\t """ 2 => """ FH Epstein \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.cir.94.12.3271" "Revista" => array:7 [ "tituloSerie" => "Circulation" "fecha" => "1996" "volumen" => "94" "numero" => "12" "paginaInicial" => "3271" "paginaFinal" => "3275" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8989140" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiotensin-induced hypoxia in the kidney: functional and structural changes of the renal circulation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ M Nangaku \n \t\t\t\t\t\t\t\t """ 1 => """ R Inagi \n \t\t\t\t\t\t\t\t """ 2 => """ T Miyata \n \t\t\t\t\t\t\t\t """ 3 => """ T Fujita \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/978-0-387-75434-5_7" "Revista" => array:6 [ "tituloSerie" => "Adv Exp Med Biol" "fecha" => "2007" "volumen" => "618" "paginaInicial" => "85" "paginaFinal" => "99" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18269190" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of calcium channel blockade on angiotensin II-induced peritubular ischemia in rats" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ N Kondo \n \t\t\t\t\t\t\t\t """ 1 => """ H Kiyomoto \n \t\t\t\t\t\t\t\t """ 2 => """ T Yamamoto \n \t\t\t\t\t\t\t\t """ 3 => """ A Miyatake \n \t\t\t\t\t\t\t\t """ 4 => """ GP Sun \n \t\t\t\t\t\t\t\t """ 5 => """ M Rahman \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1124/jpet.105.095331" "Revista" => array:7 [ "tituloSerie" => "J Pharmacol Exp Ther" "fecha" => "2006" "volumen" => "316" "numero" => "3" "paginaInicial" => "1047" "paginaFinal" => "1052" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16319305" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Activation of the renin-angiotensin system and chronic hypoxia of the kidney" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ M Nangaku \n \t\t\t\t\t\t\t\t """ 1 => """ T Fujita \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1291/hypres.31.175" "Revista" => array:8 [ "tituloSerie" => "Hypertens Res" "fecha" => "2008" "volumen" => "31" "numero" => "2" "paginaInicial" => "175" "paginaFinal" => "184" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18360035" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0012369220321061" "estado" => "S300" "issn" => "00123692" ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Breath-hold R2* mapping with a multiple gradient-recalled echo sequence: application to the evaluation of intrarenal oxygenation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ PV Prasad \n \t\t\t\t\t\t\t\t """ 1 => """ Q Chen \n \t\t\t\t\t\t\t\t """ 2 => """ JW Goldfarb \n \t\t\t\t\t\t\t\t """ 3 => """ FH Epstein \n \t\t\t\t\t\t\t\t """ 4 => """ RR Edelman \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jmri.1880070633" "Revista" => array:7 [ "tituloSerie" => "J Magn Reson Imaging" "fecha" => "1997" "volumen" => "7" "numero" => "6" "paginaInicial" => "1163" "paginaFinal" => "1165" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9400864" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Increased renovascular response to angiotensin II in persons genetically predisposed to arterial hypertension disappears after chronic angiotensin-converting enzyme inhibition" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ H Schachinger \n \t\t\t\t\t\t\t\t """ 1 => """ T Dieterle \n \t\t\t\t\t\t\t\t """ 2 => """ B Martina \n \t\t\t\t\t\t\t\t """ 3 => """ C Haberthur \n \t\t\t\t\t\t\t\t """ 4 => """ PR Huber \n \t\t\t\t\t\t\t\t """ 5 => """ A Bock \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/00004872-200401000-00027" "Revista" => array:7 [ "tituloSerie" => "J Hypertens" "fecha" => "2004" "volumen" => "22" "numero" => "1" "paginaInicial" => "175" "paginaFinal" => "180" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15106809" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal hemodynamic actions of angiotensin II: interaction with tubuloglomerular feedback" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ JE Hall \n \t\t\t\t\t\t\t\t """ 1 => """ JP Granger \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/ajpregu.1983.245.2.R166" "Revista" => array:7 [ "tituloSerie" => "Am J Physiol" "fecha" => "1983" "volumen" => "245" "numero" => "2" "paginaInicial" => "R166" "paginaFinal" => "R173" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6881375" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Assessment of acute renal transplant rejection with blood oxygen level-dependent MR imaging: initial experience" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ EA Sadowski \n \t\t\t\t\t\t\t\t """ 1 => """ SB Fain \n \t\t\t\t\t\t\t\t """ 2 => """ SK Alford \n \t\t\t\t\t\t\t\t """ 3 => """ FR Korosec \n \t\t\t\t\t\t\t\t """ 4 => """ J Fine \n \t\t\t\t\t\t\t\t """ 5 => """ R Muehrer \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1148/radiol.2363041080" "Revista" => array:7 [ "tituloSerie" => "Radiology" "fecha" => "2005" "volumen" => "236" "numero" => "3" "paginaInicial" => "911" "paginaFinal" => "919" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16118170" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of furosemide on medullary oxygenation in younger and older subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ FH Epstein \n \t\t\t\t\t\t\t\t """ 1 => """ P Prasad \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1755.2000.00057.x" "Revista" => array:7 [ "tituloSerie" => "Kidney Int" "fecha" => "2000" "volumen" => "57" "numero" => "5" "paginaInicial" => "2080" "paginaFinal" => "2083" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10792627" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tissue angiotensin converting enzyme in cardiac and vascular hypertrophy, repair, and remodeling" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ CI Johnston \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.hyp.23.2.258" "Revista" => array:7 [ "tituloSerie" => "Hypertension" "fecha" => "1994" "volumen" => "23" "numero" => "2" "paginaInicial" => "258" "paginaFinal" => "268" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8307637" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ VJ Dzau \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.hyp.37.4.1047" "Revista" => array:7 [ "tituloSerie" => "Hypertension" "fecha" => "2001" "volumen" => "37" "numero" => "4" "paginaInicial" => "1047" "paginaFinal" => "1052" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11304501" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Evaluation of Renal Hypoxia in Diabetic Mice by BOLD MRI" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ P Prasad \n \t\t\t\t\t\t\t\t """ 1 => """ LP Li \n \t\t\t\t\t\t\t\t """ 2 => """ S Halter \n \t\t\t\t\t\t\t\t """ 3 => """ J Cabray \n \t\t\t\t\t\t\t\t """ 4 => """ M Ye \n \t\t\t\t\t\t\t\t """ 5 => """ D Batlle \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/RLI.0b013e3181ec9b02" "Revista" => array:7 [ "tituloSerie" => "Investigative radiology" "fecha" => "2010" "volumen" => "45" "numero" => "12" "paginaInicial" => "819" "paginaFinal" => "822" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20829708" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Renal diffusion and BOLD MRI in experimental diabetic nephropathy" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ M Ries \n \t\t\t\t\t\t\t\t """ 1 => """ F Basseau \n \t\t\t\t\t\t\t\t """ 2 => """ B Tyndal \n \t\t\t\t\t\t\t\t """ 3 => """ R Jones \n \t\t\t\t\t\t\t\t """ 4 => """ C Deminiere \n \t\t\t\t\t\t\t\t """ 5 => """ B Catargi \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jmri.10224" "Revista" => array:7 [ "tituloSerie" => "Blood oxygen level-dependent. J Magn Reson Imaging" "fecha" => "2003" "volumen" => "17" "numero" => "1" "paginaInicial" => "104" "paginaFinal" => "113" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12500279" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Role of nitric oxide in renal papillary blood flow and sodium excretion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ DL Mattson \n \t\t\t\t\t\t\t\t """ 1 => """ RJ Roman \n \t\t\t\t\t\t\t\t """ 2 => """ AW Cowley Jr \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.hyp.19.6.766" "Revista" => array:7 [ "tituloSerie" => "Hypertension" "fecha" => "1992" "volumen" => "19" "numero" => "6 Pt 2" "paginaInicial" => "766" "paginaFinal" => "769" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1592478" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Afferent arteriolar reactivity to angiotensin II is enhanced during the early phase of angiotensin II hypertension" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ JD Imig \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/s0895-7061(00)00264-8" "Revista" => array:7 [ "tituloSerie" => "Am J Hypertens" "fecha" => "2000" "volumen" => "13" "numero" => "7" "paginaInicial" => "810" "paginaFinal" => "818" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10933574" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Prevention of type 2 diabetes mellitus with angiotensin-converting-enzyme inhibitors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ LV Solski \n \t\t\t\t\t\t\t\t """ 1 => """ DS Longyhore \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2146/ajhp070388" "Revista" => array:7 [ "tituloSerie" => "Am J Health Syst Pharm" "fecha" => "2008" "volumen" => "65" "numero" => "10" "paginaInicial" => "935" "paginaFinal" => "940" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18463342" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Protective effects of ACE inhibitors on vascular endothelial dysfunction induced by exogenous advanced oxidation protein products in rats" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ SX Chen \n \t\t\t\t\t\t\t\t """ 1 => """ T Song \n \t\t\t\t\t\t\t\t """ 2 => """ SH Zhou \n \t\t\t\t\t\t\t\t """ 3 => """ YH Liu \n \t\t\t\t\t\t\t\t """ 4 => """ SJ Wu \n \t\t\t\t\t\t\t\t """ 5 => """ LY Liu \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejphar.2008.02.020" "Revista" => array:7 [ "tituloSerie" => "European journal of pharmacology" "fecha" => "2008" "volumen" => "584" "numero" => "2-3" "paginaInicial" => "368" "paginaFinal" => "375" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18334254" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Opposed effects of prostaglandin E2 on perfusion of rat renal cortex and medulla: interactions with the renin-angiotensin system" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ B Badzynska \n \t\t\t\t\t\t\t\t """ 1 => """ J Sadowski \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1113/expphysiol.2008.043604" "Revista" => array:7 [ "tituloSerie" => "Experimental physiology" "fecha" => "2008" "volumen" => "93" "numero" => "12" "paginaInicial" => "1292" "paginaFinal" => "1302" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18586855" "web" => "Medline" ] ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cellular and metabolic consequences of chronic ischemia on kidney function" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ PS Kellerman \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:7 [ "tituloSerie" => "Semin Nephrol" "fecha" => "1996" "volumen" => "16" "numero" => "1" "paginaInicial" => "33" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8720084" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Blood oxygen level-dependent measurement of acute intra-renal ischemia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ L Juillard \n \t\t\t\t\t\t\t\t """ 1 => """ LO Lerman \n \t\t\t\t\t\t\t\t """ 2 => """ DG Kruger \n \t\t\t\t\t\t\t\t """ 3 => """ JA Haas \n \t\t\t\t\t\t\t\t """ 4 => """ BC Rucker \n \t\t\t\t\t\t\t\t """ 5 => """ JA Polzin \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1523-1755.2004.00469.x" "Revista" => array:7 [ "tituloSerie" => "Kidney Int" "fecha" => "2004" "volumen" => "65" "numero" => "3" "paginaInicial" => "944" "paginaFinal" => "950" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14871414" "web" => "Medline" ] ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiotensin II decreases the renal MRI blood oxygenation level-dependent signal" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => """ H Schachinger \n \t\t\t\t\t\t\t\t """ 1 => """ M Klarhofer \n \t\t\t\t\t\t\t\t """ 2 => """ L Linder \n \t\t\t\t\t\t\t\t """ 3 => """ J Drewe \n \t\t\t\t\t\t\t\t """ 4 => """ K Scheffler \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1161/01.HYP.0000220109.98142.a3" "Revista" => array:7 [ "tituloSerie" => "Hypertension" "fecha" => "2006" "volumen" => "47" "numero" => "6" "paginaInicial" => "1062" "paginaFinal" => "1066" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16618841" "web" => "Medline" ] ] ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Non-invasive monitoring of renal oxygenation using BOLD-MRI: a reproducibility study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ SC Simon-Zoula \n \t\t\t\t\t\t\t\t """ 1 => """ L Hofmann \n \t\t\t\t\t\t\t\t """ 2 => """ A Giger \n \t\t\t\t\t\t\t\t """ 3 => """ B Vogt \n \t\t\t\t\t\t\t\t """ 4 => """ P Vock \n \t\t\t\t\t\t\t\t """ 5 => """ FJ Frey \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/nbm.1004" "Revista" => array:7 [ "tituloSerie" => "NMR Biomed" "fecha" => "2006" "volumen" => "19" "numero" => "1" "paginaInicial" => "84" "paginaFinal" => "89" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16411163" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "BOLD-MRI for the assessment of renal oxygenation in humans: acute effect of nephrotoxic xenobiotics" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ L Hofmann \n \t\t\t\t\t\t\t\t """ 1 => """ S Simon-Zoula \n \t\t\t\t\t\t\t\t """ 2 => """ A Nowak \n \t\t\t\t\t\t\t\t """ 3 => """ A Giger \n \t\t\t\t\t\t\t\t """ 4 => """ P Vock \n \t\t\t\t\t\t\t\t """ 5 => """ C Boesch \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1038/sj.ki.5000418" "Revista" => array:7 [ "tituloSerie" => "Kidney Int" "fecha" => "2006" "volumen" => "70" "numero" => "1" "paginaInicial" => "144" "paginaFinal" => "150" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16641929" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of diabetes on renal medullary oxygenation during water diuresis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ FH Epstein \n \t\t\t\t\t\t\t\t """ 1 => """ A Veves \n \t\t\t\t\t\t\t\t """ 2 => """ PV Prasad \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.2337/diacare.25.3.575" "Revista" => array:7 [ "tituloSerie" => "Diabetes Care" "fecha" => "2002" "volumen" => "25" "numero" => "3" "paginaInicial" => "575" "paginaFinal" => "578" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11874950" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Visualization and quantification of renal R2* changes during water diuresis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ CS Zuo \n \t\t\t\t\t\t\t\t """ 1 => """ NM Rofsky \n \t\t\t\t\t\t\t\t """ 2 => """ H Mahallati \n \t\t\t\t\t\t\t\t """ 3 => """ J Yu \n \t\t\t\t\t\t\t\t """ 4 => """ M Zhang \n \t\t\t\t\t\t\t\t """ 5 => """ S Gilbert \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1002/jmri.10314" "Revista" => array:7 [ "tituloSerie" => "J Magn Reson Imaging" "fecha" => "2003" "volumen" => "17" "numero" => "6" "paginaInicial" => "676" "paginaFinal" => "682" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12766897" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ RC Blantz \n \t\t\t\t\t\t\t\t """ 1 => """ KS Konnen \n \t\t\t\t\t\t\t\t """ 2 => """ BJ Tucker \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1172/JCI108293" "Revista" => array:7 [ "tituloSerie" => "J Clin Invest" "fecha" => "1976" "volumen" => "57" "numero" => "2" "paginaInicial" => "419" "paginaFinal" => "434" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1254727" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Paracrine regulation of the renal microcirculation" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ LG Navar \n \t\t\t\t\t\t\t\t """ 1 => """ EW Inscho \n \t\t\t\t\t\t\t\t """ 2 => """ SA Majid \n \t\t\t\t\t\t\t\t """ 3 => """ JD Imig \n \t\t\t\t\t\t\t\t """ 4 => """ LM Harrison-Bernard \n \t\t\t\t\t\t\t\t """ 5 => """ KD Mitchell \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1152/physrev.1996.76.2.425" "Revista" => array:7 [ "tituloSerie" => "Physiol Rev" "fecha" => "1996" "volumen" => "76" "numero" => "2" "paginaInicial" => "425" "paginaFinal" => "536" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8618962" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Changes in renal medullary pO2 during water diuresis as evaluated by blood oxygenation level-dependent magnetic resonance imaging: effects of aging and cyclooxygenase inhibition" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => """ PV Prasad \n \t\t\t\t\t\t\t\t """ 1 => """ FH Epstein \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1046/j.1523-1755.1999.00237.x" "Revista" => array:8 [ "tituloSerie" => "Kidney Int" "fecha" => "1999" "volumen" => "55" "numero" => "1" "paginaInicial" => "294" "paginaFinal" => "298" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9893139" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S0016508515005752" "estado" => "S300" "issn" => "00165085" ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39" "referencia" => array:1 [ 0 => array:1 [ "referenciaCompleta" => "Gloviczki ML, Lerman LO, Textor SC. Blood Oxygen Level-Dependent (BOLD) MRI in Renovascular Hypertension. Current hypertension reports.13(5):370-7." ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "BOLD imaging: a potential predictive biomarker of renal functional outcome following revascularization in atheromatous renovascular disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ C Chrysochou \n \t\t\t\t\t\t\t\t """ 1 => """ IA Mendichovszky \n \t\t\t\t\t\t\t\t """ 2 => """ DL Buckley \n \t\t\t\t\t\t\t\t """ 3 => """ CM Cheung \n \t\t\t\t\t\t\t\t """ 4 => """ A Jackson \n \t\t\t\t\t\t\t\t """ 5 => """ PA Kalra \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1093/ndt/gfr392" "Revista" => array:7 [ "tituloSerie" => "Nephrol Dial Transplant" "fecha" => "2012" "volumen" => "27" "numero" => "3" "paginaInicial" => "1013" "paginaFinal" => "1019" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21856759" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] "agradecimientos" => array:1 [ 0 => array:4 [ "identificador" => "xack639554" "titulo" => "ACKNOWLEDGMENTS" "texto" => "<p id="para360" class="elsevierStylePara elsevierViewall">We wish to thank the volunteers for their contribution to science and Sergio Kakuta Kato and Ângelo de Souza for their assistance.</p>" "vista" => "all" ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000006700000007/v1_202212011706/S1807593222017690/v1_202212011706/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006700000007/v1_202212011706/S1807593222017690/v1_202212011706/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222017690?idApp=UINPBA00004N" ]
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