Letter to The Editor
Pseudomyxoma peritonei syndrome 12 months after an intact resection of malignant mucocele of the appendix: A case report
Leonardo Maciel da Fonseca, Antônio Lacerda-Filho, Rodrigo Gomes da Silva
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Grupo de Coloproctologia e Intestino Delgado, Instituto Alfa de Gastroenterologia do Hospital das Clínicas da Universidade Federal de Minas Gerais (UFMG) – Belo Horizonte/MG, Brazil
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MAs are rare lesions found in only 0.2%–0.3% of appendectomies.<a class="elsevierStyleCrossRef" href="#bib1">1</a> Malignant mucoceles are found even less frequently.<a class="elsevierStyleCrossRef" href="#bib2">2</a></p><p id="para20" class="elsevierStylePara elsevierViewall">It is believed that an intact mucocele presents no risk for the patient. González Moreno et al.<a class="elsevierStyleCrossRef" href="#bib3">3</a> has emphasized that peritoneal seeding should be preventable with atraumatic handling of the cancer specimen. These authors also noted that peritoneal dissemination from a MA has not been regarded as a problem with open appendectomy. The incidence of disseminated peritoneal mucinous tumors from an open appendectomy is extremely low, and no reported cases were found in the literature.</p><p id="para30" class="elsevierStylePara elsevierViewall">We report the case of a patient with no rupture of the MA during the primary surgery who presented after 12 months of follow-up with peritoneal dissemination typical of pseudomyxoma peritonei (PP). To the best of our knowledge, no such case has previously been reported.</p></span><span id="cesec20" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle20">Case Report</span><p id="para40" class="elsevierStylePara elsevierViewall">A 40-year-old female patient presented with abdominal pain lasting 3 months. The patient underwent an abdominal CT scan that showed a 12-cm well-encapsulated cystic mass in the right lower quadrant (<a class="elsevierStyleCrossRef" href="#fig1-cln_65p817">Figure 1A</a>). However, there was no mucinous ascites, and MA of malignant origin was suspected.</p><elsevierMultimedia ident="fig1-cln_65p817"></elsevierMultimedia><p id="para50" class="elsevierStylePara elsevierViewall">A median laparotomy, rather than a laparoscopic approach, was indicated to avoid rupturing the tumor. A right hemicolectomy (RHC) was performed due to tumor size . The surgical field was protected with pads to prevent the contamination of tumor cells into the peritoneal cavity. The specimen was removed intact (<a class="elsevierStyleCrossRef" href="#fig1-cln_65p817">Figure 1B</a>). The pathologic exam showed mucinous cystadenocarcinoma of the appendix without rupture. No metastases were found in 31 tested lymph nodes.</p><p id="para60" class="elsevierStylePara elsevierViewall">One year later, the patient was found to have an elevated serum carcinoembryonic antigen. On the pelvic CT, a tumor mass involving the right ovary and salpinx was discovered. A cytoreductive surgery was indicated. During laparotomy, four-quadrant peritoneal dissemination of the tumor was observed along with a large tumor involving the right ovary. An extensive 10-hour cytoreductive surgery, as recommended by Sugarbaker,<a class="elsevierStyleCrossRef" href="#bib4">4</a> was performed; additionally, the patient received 90 minutes of intraperitoneal chemotherapy with mitomycin C. During the postoperative period, the patient developed pneumonia in the ICU and died 30 days after the procedure.</p></span><span id="cesec30" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle30">Discussion</span><p id="para70" class="elsevierStylePara elsevierViewall">During procedures involving mucoceles caused by mucinous cystadenomas and cystadenocarcinomas, the most important concern for the surgeon is that a possible rupture of the mucocele, either spontaneous or accidental, may result in PP.<a class="elsevierStyleCrossRef" href="#bib5">5</a></p><p id="para80" class="elsevierStylePara elsevierViewall">Considering these concerns, an oncological RHC was performed to prevent both tumor cell spillage into the peritoneal cavity and rupture of the mucocele. Unfortunately, this patient presented with metastasis of malignant cells throughout the peritoneal cavity in the form of multiple mucinous deposits at 12 months after the initial surgery.</p><p id="para90" class="elsevierStylePara elsevierViewall">MA of malignant origin may result in the PP syndrome even after an intact tumor resection has been performed. We believe that intraperitoneal chemotherapy should be used in addition to the primary surgical treatment of MA even for intact tumor resections.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:4 [ 0 => array:2 [ "identificador" => "cesec10" "titulo" => "INTRODUCTION" ] 1 => array:2 [ "identificador" => "cesec20" "titulo" => "Case Report" ] 2 => array:2 [ "identificador" => "cesec30" "titulo" => "Discussion" ] 3 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara" id="cenpara10">This work was presented at 6<span class="elsevierStyleSup">th</span> International Workshop on Peritoneal Surface Malignancy, Lyon, France, 2008.</p> <p class="elsevierStyleNotepara" id="cenpara20">This work was supported by FAPEMIG (Fundação de Amparo à Pesquisa do Estado de Minas Gerais).</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig1-cln_65p817" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 636 "Ancho" => 442 "Tamanyo" => 73541 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">A) CT scan showing a well-encapsulated cystic mass in the right lower quadrant (arrow); B) Mucocele of the appendix.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:5 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Mucocele of the appendix: a report of five cases" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => """ M Pitiakoudis \n \t\t\t\t\t\t\t\t """ 1 => """ AK Tsaroucha \n \t\t\t\t\t\t\t\t """ 2 => """ K Mimidis \n \t\t\t\t\t\t\t\t """ 3 => """ A Polychronidis \n \t\t\t\t\t\t\t\t """ 4 => """ G Minopoulos \n \t\t\t\t\t\t\t\t """ 5 => """ C Simopoulos \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Tech Coloproctol" "fecha" => "2004" "volumen" => "8" "paginaInicial" => "109" "paginaFinal" => "112" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "10.1007/s10151-004-0067-3" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Primary carcinoma of the appendix" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ A Andersson \n \t\t\t\t\t\t\t\t """ 1 => """ L Bergdahl \n \t\t\t\t\t\t\t\t """ 2 => """ L Boquist \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Ann Surg" "fecha" => "1976" "volumen" => "183" "paginaInicial" => "53" "paginaFinal" => "57" ] ] 1 => array:1 [ "WWW" => array:1 [ "link" => "10.1097/00000658-197601000-00011" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Appendiceal mucocele. Contraindication to laparoscopic appendectomy" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => """ S Gonzalez Moreno \n \t\t\t\t\t\t\t\t """ 1 => """ BM Shmookler \n \t\t\t\t\t\t\t\t """ 2 => """ PH Sugarbaker \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1007/s004649900811" "Revista" => array:6 [ "tituloSerie" => "Surg Endosc" "fecha" => "1998" "volumen" => "12" "paginaInicial" => "1177" "paginaFinal" => "1179" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9716778" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1007/s004649900811" "WWW" => array:1 [ "link" => "10.1007/s004649900811" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Peritonectomy procedures" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => """ PH Sugarbaker \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:2 [ 0 => array:2 [ "doi" => "10.1097/00000658-199501000-00004" "Revista" => array:6 [ "tituloSerie" => "Ann Surg" "fecha" => "1995" "volumen" => "221" "paginaInicial" => "29" "paginaFinal" => "42" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7826158" "web" => "Medline" ] ] ] ] 1 => array:2 [ "doi" => "10.1097/00000658-199501000-00004" "WWW" => array:1 [ "link" => "10.1097/00000658-199501000-00004" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Appendiceal mucoceles and pseudomyxoma peritonei" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => """ S Landen \n \t\t\t\t\t\t\t\t """ 1 => """ C Bertrand \n \t\t\t\t\t\t\t\t """ 2 => """ GJ Maddern \n \t\t\t\t\t\t\t\t """ 3 => """ D Herman \n \t\t\t\t\t\t\t\t """ 4 => """ A Pourbaix \n \t\t\t\t\t\t\t\t """ 5 => """ A de Neve \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Surg Gynecol Obstet" "fecha" => "1992" "volumen" => "175" "paginaInicial" => "401" "paginaFinal" => "404" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1440166" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/18075932/0000006500000008/v1_202212010734/S1807593222019044/v1_202212010734/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/18075932/0000006500000008/v1_202212010734/S1807593222019044/v1_202212010734/en/main.pdf?idApp=UINPBA00004N&text.app=https://www.elsevier.es/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222019044?idApp=UINPBA00004N" ]
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