CASE REPORT
Coronary atherosclerotic plaque rupture following thoracic trauma – an uncommon cause of angina and ventricular tachycardia (“torsade de pointes”)
Luís Henrique Wolff Gowdak, Márcio Sommer Bittencourt
, Carlos Eduardo Rochitte, Luís Alberto Oliveira Dallan, Luiz Antonio Machado César
Corresponding author
Cardiologia Clínica, Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brazil.
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"autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Thayana Ribeiro Kajitani, Renata Viana da Silva, Eloisa Bonfá, Rosa M R Pereira" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Thayana Ribeiro" "apellidos" => "Kajitani" ] 1 => array:2 [ "nombre" => "Renata Viana" "apellidos" => "da Silva" ] 2 => array:2 [ "nombre" => "Eloisa" "apellidos" => "Bonfá" ] 3 => array:2 [ "nombre" => "Rosa M R" "apellidos" => "Pereira" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1807593222020282?idApp=UINPBA00004N" "url" => "/18075932/0000006600000007/v1_202212011408/S1807593222020282/v1_202212011408/en/main.assets" ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">CASE REPORT</span>" "titulo" => "Coronary atherosclerotic plaque rupture following thoracic trauma – an uncommon cause of angina and ventricular tachycardia (<span class="elsevierStyleItalic">“torsade de pointes”</span>)" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1291" "paginaFinal" => "1293" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Luís Henrique Wolff Gowdak, Márcio Sommer Bittencourt, Carlos Eduardo Rochitte, Luís Alberto Oliveira Dallan, Luiz Antonio Machado César" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Luís Henrique Wolff" "apellidos" => "Gowdak" ] 1 => array:4 [ "nombre" => "Márcio Sommer" "apellidos" => "Bittencourt" "email" => array:1 [ 0 => "msbittencourt@bol.com.br" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "*" "identificador" => "cor1" ] ] ] 2 => array:2 [ "nombre" => "Carlos Eduardo" "apellidos" => "Rochitte" ] 3 => array:2 [ "nombre" => "Luís Alberto Oliveira" "apellidos" => "Dallan" ] 4 => array:2 [ "nombre" => "Luiz Antonio Machado" "apellidos" => "César" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Cardiologia Clínica, Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, São Paulo/SP, Brazil." "identificador" => "aff1" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Tel.: 55 11 30623124" ] ] ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 411 "Ancho" => 442 "Tamanyo" => 17913 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">A coronary-computed tomography angiogram indicating a low-density image in the proximal segment of the LAD that is compatible with a coronary thrombus (white arrows).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="cesec10" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="cestitle10">CASE REPORT</span><p id="para10" class="elsevierStylePara elsevierViewall">Blunt thoracic trauma has been previously described as a rare and often missed cause of acute myocardial infarction,<a class="elsevierStyleCrossRef" href="#bib1">1</a> cardiac rupture, ventricular aneurysms,<a class="elsevierStyleCrossRef" href="#bib2">2</a> aortocoronary bypass occlusion,<a class="elsevierStyleCrossRef" href="#bib3">3</a> coronary aneurysms,<a class="elsevierStyleCrossRef" href="#bib4">4</a> angina,<a class="elsevierStyleCrossRef" href="#bib5">5</a> and arrhythmias.<a class="elsevierStyleCrossRef" href="#bib6">6</a></p><p id="para20" class="elsevierStylePara elsevierViewall">Here, we report the case of a 44-year-old man whose complaints of exertional chest pain and lightheadedness began after suffering a motor-tricycle accident with blunt thoracic trauma 1 month earlier. His past history was unremarkable except for mild hypercholesterolemia; he was overweight and had a familial history of early-onset myocardial infarction.</p><p id="para30" class="elsevierStylePara elsevierViewall">Immediately after the accident, the patient began to experience chest pain associated with lightheadedness, sweating, and pale skin while walking briskly; the symptoms were relieved by resting and lasted less than five minutes. He sought medical attention in an emergency department from another facility seven days after the accident. Bruises were observed in the epigastrium close to the 12<span class="elsevierStyleSup">th</span> left costal arch, with tenderness in the left anterior thoracic wall; the physical exam was otherwise normal. No fractures were revealed by a chest X-ray. A 12-lead resting ECG yielded normal results, but CKMB-mass and troponin-I levels were slightly elevated. Coronary angiography was performed and revealed a non-obstructive plaque in the left main coronary artery (LM) and 50% stenosis of the proximal left anterior descending artery (LAD). No obstructions were seen in the circumflex or right coronary artery. Cardiac scintigraphy (<span class="elsevierStyleSup">99m</span>Tc- Sestamibi with dipyridamole) did not indicate any myocardial perfusion defects; a transthoracic echocardiogram revealed preserved left ventricular function and a very small pericardial effusion with no sign of cardiac restriction. The patient was discharged with diagnoses of uncomplicated thoracic trauma and non-critical coronary atherosclerosis, with a referral for medical treatment.</p><p id="para40" class="elsevierStylePara elsevierViewall">Amlodipine, aspirin, and pravastatin were prescribed, but the patient's symptoms did not improve. Due to the persistence of symptoms, the patient was later seen by a cardiologist, who ordered a treadmill test. During the first stage of the Bruce protocol, between the 2<span class="elsevierStyleSup">nd</span> and 3<span class="elsevierStyleSup">rd</span> minutes of exercise, the patient developed a non-sustained polymorphic ventricular tachycardia (<span class="elsevierStyleItalic">“torsade de pointes”</span>) (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1A</a>), followed by ST-T ischemic changes (<a class="elsevierStyleCrossRef" href="#fig1">Figure 1B</a>).</p><elsevierMultimedia ident="fig1"></elsevierMultimedia><p id="para50" class="elsevierStylePara elsevierViewall">A high-resolution ECG and cardiac magnetic resonance imaging study were normal, excluding right ventricular dysplasia and myocardial fibrosis due to myocarditis or to an old infarction scar. Previously undiagnosed myocardial ischemia secondary to coronary atherosclerosis was presumed to be the cause for his symptoms, along with exercise-induced ventricular arrhythmia. Surgical myocardial revascularization was therefore advised.</p><p id="para60" class="elsevierStylePara elsevierViewall">Due to the persistence of symptoms and the high-risk features of the patient's treadmill activity (not only because of the low level of activity associated with ischemic changes but also because of the high-risk arrhythmia associated with the ischemic changes), surgical treatment was chosen as the most appropriate therapy.</p><p id="para70" class="elsevierStylePara elsevierViewall">The patient underwent an off-pump coronary artery bypass graft with arterial grafts to the LAD and circumflex arteries four weeks after the initial presentation. It should be noted that, during surgery and before the graft was placed, as the surgeon inspected the heart looking for evidence of cardiac trauma, ST-T elevation was observed on the heart monitor. This observation was confirmed by ECG and persisted for 24 h, evolving with new Q waves in leads II and III and poor progression of R waves in leads V1 through V3, with a striking elevation of CKMB-mass (which peaked at 25 times the normal level 17 h after surgery). An echocardiogram performed on the second day postoperatively revealed a very small area of hypokinesia in the apex. The patient had an uneventful recovery. An echocardiogram performed at the one-month follow-up was completely normal.</p><p id="para80" class="elsevierStylePara elsevierViewall">Another treadmill test was performed forty days after surgery; the patient was able to tolerate maximal exercise, and no ECG changes suggestive of myocardial ischemia or arrhythmias were observed. A coronary computed tomography angiogram (16×0.5-MDCTA, Aquilion16TM, Toshiba Medical Systems Corporation, Otawara, Japan) with calcium score evaluation revealed a non-calcified atherosclerotic plaque on the proximal segment of the LAD. Inside the plaque, an area of very low density (<40 Hounsfield Units) was observed (<a class="elsevierStyleCrossRef" href="#fig2">Figure 2</a>), a finding compatible with a coronary thrombus. Both of the grafts were patent.</p><elsevierMultimedia ident="fig2"></elsevierMultimedia><p id="para90" class="elsevierStylePara elsevierViewall">Although acute myocardial infarction (AMI) caused by a trauma with laceration of the coronary arteries has been previously described in many case reports,<a class="elsevierStyleCrossRefs" href="#bib1">1,7</a> especially in the vicinity of the LAD, most reported cases involved ST-elevation MI or ventricular aneurysm preceded by a history of trauma, as recently reviewed.8 In the present case, myocardial necrosis was detected by serum markers one week after chest trauma, even though the ECG remained normal. Coronary intravascular ultrasound was not recommended to further investigate the extension of the stenotic lesions due to the risk of disrupting the left main plaque. Thus, the initial CK-MB and elevation of troponin might have been caused by direct trauma, whereas the ruptured plaque and thrombus might be responsible for the delayed clinical symptoms.</p><p id="para100" class="elsevierStylePara elsevierViewall">Notably, there was a striking moment in time relating the thoracic trauma and the onset of anginal symptoms. We believe that a more careful interpretation of the patient's presenting symptoms would have been helpful to identify the cause. Non-invasive imaging revealed a coronary thrombus inside an atherosclerotic plaque, most likely resulting from the chest trauma and leading to exercise-induced ischemia and malignant ventricular arrhythmia. However, the possibility of post-CABG thrombus formation cannot be excluded, as the CT was only performed after surgery.</p><p id="para110" class="elsevierStylePara elsevierViewall">Another important finding in this case report was the intraoperative myocardial infarction. The most probable etiology of this event was the dislodgement and embolization from the thrombus, which previously rested on the ruptured plaque. Other possible causes of intraoperative myocardial infarction, including hemodynamic instability or surgical technique, are improbable in the present case.</p><p id="para120" class="elsevierStylePara elsevierViewall">At a follow-up visit one year after the procedure, the patient was doing well and had not experienced the recurrence of any of his symptoms.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "cesec10" "titulo" => "CASE REPORT" ] 1 => array:2 [ "identificador" => "xack639277" "titulo" => "ACKNOWLEDGEMENT" ] 2 => array:1 [ "titulo" => "REFERENCES" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig1" "etiqueta" => "Figure 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 491 "Ancho" => 661 "Tamanyo" => 88564 ] ] "descripcion" => array:1 [ "en" => "<p id="spara10" class="elsevierStyleSimplePara elsevierViewall">A treadmill test (Bruce protocol) indicating a non-sustained polymorphic ventricular tachycardia (<span class="elsevierStyleItalic">“torsade de pointes”</span>) (Panel A), followed by ST-T ischemic changes (Panel B).</p>" ] ] 1 => array:7 [ "identificador" => "fig2" "etiqueta" => "Figure 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 411 "Ancho" => 442 "Tamanyo" => 17913 ] ] "descripcion" => array:1 [ "en" => "<p id="spara20" class="elsevierStyleSimplePara elsevierViewall">A coronary-computed tomography angiogram indicating a low-density image in the proximal segment of the LAD that is compatible with a coronary thrombus (white arrows).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "cebibsec10" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Blunt chest trauma producing acute myocardial infarction in a rugby player" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ AR Vasudevan \n \t\t\t\t\t\t\t\t """ 1 => """ GS Kabinoff \n \t\t\t\t\t\t\t\t """ 2 => """ TN Keltz \n \t\t\t\t\t\t\t\t """ 3 => """ B Gitler \n \t\t\t\t\t\t\t\t """ ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Lancet" "fecha" => "2003" "volumen" => "362" "paginaInicial" => "70" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Traumatic cardiac rupture and left ventricular aneurismal formation in childhood" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => """ AS Matthew \n \t\t\t\t\t\t\t\t """ 1 => 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| 2023 October | 10 | 25 | 35 |
| 2023 September | 19 | 26 | 45 |
| 2023 August | 8 | 8 | 16 |
| 2023 July | 19 | 19 | 38 |
| 2023 June | 12 | 13 | 25 |
| 2023 May | 1 | 0 | 1 |
| 2023 March | 1 | 0 | 1 |
| 2023 February | 1 | 1 | 2 |
| 2023 January | 0 | 1 | 1 |
| 2022 December | 46 | 1 | 47 |
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